-- dump date   	20140619_030020
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
479433000001	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433000002	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
479433000003	Walker A motif; other site
479433000004	ATP binding site [chemical binding]; other site
479433000005	Walker B motif; other site
479433000006	arginine finger; other site
479433000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
479433000008	DnaA box-binding interface [nucleotide binding]; other site
479433000009	DNA polymerase III subunit beta; Validated; Region: PRK07761
479433000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
479433000011	putative DNA binding surface [nucleotide binding]; other site
479433000012	dimer interface [polypeptide binding]; other site
479433000013	beta-clamp/clamp loader binding surface; other site
479433000014	beta-clamp/translesion DNA polymerase binding surface; other site
479433000015	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
479433000016	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
479433000017	recombination protein F; Reviewed; Region: recF; PRK00064
479433000018	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
479433000019	Walker A/P-loop; other site
479433000020	ATP binding site [chemical binding]; other site
479433000021	Q-loop/lid; other site
479433000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433000023	ABC transporter signature motif; other site
479433000024	Walker B; other site
479433000025	D-loop; other site
479433000026	H-loop/switch region; other site
479433000027	Protein of unknown function (DUF721); Region: DUF721; pfam05258
479433000028	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
479433000029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433000030	Mg2+ binding site [ion binding]; other site
479433000031	G-X-G motif; other site
479433000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
479433000033	anchoring element; other site
479433000034	dimer interface [polypeptide binding]; other site
479433000035	ATP binding site [chemical binding]; other site
479433000036	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
479433000037	active site
479433000038	metal binding site [ion binding]; metal-binding site
479433000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
479433000040	DNA gyrase subunit A; Validated; Region: PRK05560
479433000041	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
479433000042	CAP-like domain; other site
479433000043	active site
479433000044	primary dimer interface [polypeptide binding]; other site
479433000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
479433000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
479433000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
479433000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
479433000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
479433000050	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
479433000051	AAA domain; Region: AAA_17; cl17253
479433000052	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
479433000053	D-mannose binding lectin; Region: B_lectin; pfam01453
479433000054	mannose binding site [chemical binding]; other site
479433000055	dimerization interface [polypeptide binding]; other site
479433000056	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
479433000057	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433000058	DNA-binding site [nucleotide binding]; DNA binding site
479433000059	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
479433000060	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433000061	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433000062	ATP binding site [chemical binding]; other site
479433000063	Mg2+ binding site [ion binding]; other site
479433000064	G-X-G motif; other site
479433000065	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
479433000066	non-specific DNA binding site [nucleotide binding]; other site
479433000067	salt bridge; other site
479433000068	sequence-specific DNA binding site [nucleotide binding]; other site
479433000069	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
479433000070	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
479433000071	active site
479433000072	NTP binding site [chemical binding]; other site
479433000073	metal binding triad [ion binding]; metal-binding site
479433000074	antibiotic binding site [chemical binding]; other site
479433000075	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433000076	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433000077	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
479433000078	non-specific DNA binding site [nucleotide binding]; other site
479433000079	salt bridge; other site
479433000080	sequence-specific DNA binding site [nucleotide binding]; other site
479433000081	Helix-turn-helix; Region: HTH_3; pfam01381
479433000082	sequence-specific DNA binding site [nucleotide binding]; other site
479433000083	salt bridge; other site
479433000084	Predicted membrane protein [Function unknown]; Region: COG2119
479433000085	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
479433000086	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
479433000087	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433000088	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433000089	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
479433000090	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433000091	putative substrate translocation pore; other site
479433000092	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
479433000093	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
479433000094	NADP binding site [chemical binding]; other site
479433000095	Predicted transcriptional regulators [Transcription]; Region: COG1733
479433000096	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433000097	dimerization interface [polypeptide binding]; other site
479433000098	putative Zn2+ binding site [ion binding]; other site
479433000099	putative DNA binding site [nucleotide binding]; other site
479433000100	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
479433000101	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
479433000102	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
479433000103	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433000104	Coenzyme A binding pocket [chemical binding]; other site
479433000105	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
479433000106	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
479433000107	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433000108	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433000109	DNA binding residues [nucleotide binding]
479433000110	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
479433000111	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
479433000112	catalytic residues [active]
479433000113	Methyltransferase domain; Region: Methyltransf_31; pfam13847
479433000114	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433000115	S-adenosylmethionine binding site [chemical binding]; other site
479433000116	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
479433000117	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
479433000118	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
479433000119	phosphopeptide binding site; other site
479433000120	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
479433000121	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
479433000122	phosphopeptide binding site; other site
479433000123	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
479433000124	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
479433000125	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
479433000126	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433000127	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433000128	active site
479433000129	ATP binding site [chemical binding]; other site
479433000130	substrate binding site [chemical binding]; other site
479433000131	activation loop (A-loop); other site
479433000132	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
479433000133	Glutamine amidotransferase class-I; Region: GATase; pfam00117
479433000134	glutamine binding [chemical binding]; other site
479433000135	catalytic triad [active]
479433000136	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
479433000137	active site
479433000138	catalytic site [active]
479433000139	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
479433000140	putative septation inhibitor protein; Reviewed; Region: PRK02251
479433000141	B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034
479433000142	Rhomboid family; Region: Rhomboid; pfam01694
479433000143	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
479433000144	active site
479433000145	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
479433000146	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
479433000147	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
479433000148	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
479433000149	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
479433000150	Walker A motif; other site
479433000151	ATP binding site [chemical binding]; other site
479433000152	Walker B motif; other site
479433000153	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
479433000154	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
479433000155	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
479433000156	Ion channel; Region: Ion_trans_2; pfam07885
479433000157	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
479433000158	TrkA-N domain; Region: TrkA_N; pfam02254
479433000159	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
479433000160	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
479433000161	dimer interface [polypeptide binding]; other site
479433000162	putative functional site; other site
479433000163	putative MPT binding site; other site
479433000164	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
479433000165	active site
479433000166	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433000167	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433000168	active site
479433000169	Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452
479433000170	active site 2 [active]
479433000171	active site 1 [active]
479433000172	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
479433000173	DUF35 OB-fold domain; Region: DUF35; pfam01796
479433000174	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433000175	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433000176	active site
479433000177	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
479433000178	putative active site [active]
479433000179	putative catalytic site [active]
479433000180	lipid-transfer protein; Provisional; Region: PRK07855
479433000181	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
479433000182	active site
479433000183	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
479433000184	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
479433000185	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
479433000186	motif II; other site
479433000187	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
479433000188	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
479433000189	DNA binding residues [nucleotide binding]
479433000190	dimer interface [polypeptide binding]; other site
479433000191	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
479433000192	pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853
479433000193	acetyl-CoA synthetase; Provisional; Region: PRK00174
479433000194	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
479433000195	active site
479433000196	CoA binding site [chemical binding]; other site
479433000197	acyl-activating enzyme (AAE) consensus motif; other site
479433000198	AMP binding site [chemical binding]; other site
479433000199	acetate binding site [chemical binding]; other site
479433000200	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
479433000201	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433000202	active site
479433000203	phosphorylation site [posttranslational modification]
479433000204	intermolecular recognition site; other site
479433000205	dimerization interface [polypeptide binding]; other site
479433000206	LytTr DNA-binding domain; Region: LytTR; smart00850
479433000207	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
479433000208	Histidine kinase; Region: His_kinase; pfam06580
479433000209	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433000210	ATP binding site [chemical binding]; other site
479433000211	Mg2+ binding site [ion binding]; other site
479433000212	G-X-G motif; other site
479433000213	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433000214	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433000215	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
479433000216	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433000217	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
479433000218	P-loop; other site
479433000219	short chain dehydrogenase; Provisional; Region: PRK07041
479433000220	classical (c) SDRs; Region: SDR_c; cd05233
479433000221	NAD(P) binding site [chemical binding]; other site
479433000222	active site
479433000223	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433000224	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433000225	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
479433000226	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
479433000227	NAD(P) binding site [chemical binding]; other site
479433000228	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
479433000229	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
479433000230	active site
479433000231	substrate binding site [chemical binding]; other site
479433000232	ATP binding site [chemical binding]; other site
479433000233	Predicted esterase [General function prediction only]; Region: COG0627
479433000234	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
479433000235	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
479433000236	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
479433000237	nucleotide binding site [chemical binding]; other site
479433000238	NEF interaction site [polypeptide binding]; other site
479433000239	SBD interface [polypeptide binding]; other site
479433000240	GrpE; Region: GrpE; pfam01025
479433000241	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
479433000242	dimer interface [polypeptide binding]; other site
479433000243	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
479433000244	chaperone protein DnaJ; Provisional; Region: PRK14286
479433000245	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
479433000246	HSP70 interaction site [polypeptide binding]; other site
479433000247	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
479433000248	Zn binding sites [ion binding]; other site
479433000249	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
479433000250	dimer interface [polypeptide binding]; other site
479433000251	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
479433000252	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
479433000253	DNA binding residues [nucleotide binding]
479433000254	putative dimer interface [polypeptide binding]; other site
479433000255	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
479433000256	Clp amino terminal domain; Region: Clp_N; pfam02861
479433000257	Clp amino terminal domain; Region: Clp_N; pfam02861
479433000258	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433000259	Walker A motif; other site
479433000260	ATP binding site [chemical binding]; other site
479433000261	Walker B motif; other site
479433000262	arginine finger; other site
479433000263	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433000264	Walker A motif; other site
479433000265	ATP binding site [chemical binding]; other site
479433000266	Walker B motif; other site
479433000267	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
479433000268	Protein of unknown function (DUF3037); Region: DUF3037; pfam11236
479433000269	short chain dehydrogenase; Provisional; Region: PRK05872
479433000270	classical (c) SDRs; Region: SDR_c; cd05233
479433000271	NAD(P) binding site [chemical binding]; other site
479433000272	active site
479433000273	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433000274	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433000275	active site
479433000276	ATP binding site [chemical binding]; other site
479433000277	substrate binding site [chemical binding]; other site
479433000278	activation loop (A-loop); other site
479433000279	Predicted amidohydrolase [General function prediction only]; Region: COG0388
479433000280	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
479433000281	putative active site [active]
479433000282	catalytic triad [active]
479433000283	putative dimer interface [polypeptide binding]; other site
479433000284	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
479433000285	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
479433000286	E3 interaction surface; other site
479433000287	lipoyl attachment site [posttranslational modification]; other site
479433000288	e3 binding domain; Region: E3_binding; pfam02817
479433000289	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
479433000290	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
479433000291	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
479433000292	alpha subunit interface [polypeptide binding]; other site
479433000293	TPP binding site [chemical binding]; other site
479433000294	heterodimer interface [polypeptide binding]; other site
479433000295	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
479433000296	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
479433000297	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
479433000298	TPP-binding site [chemical binding]; other site
479433000299	heterodimer interface [polypeptide binding]; other site
479433000300	tetramer interface [polypeptide binding]; other site
479433000301	phosphorylation loop region [posttranslational modification]
479433000302	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433000303	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433000304	active site
479433000305	phosphorylation site [posttranslational modification]
479433000306	intermolecular recognition site; other site
479433000307	dimerization interface [polypeptide binding]; other site
479433000308	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433000309	DNA binding residues [nucleotide binding]
479433000310	dimerization interface [polypeptide binding]; other site
479433000311	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433000312	hypothetical protein; Provisional; Region: PRK06753
479433000313	hypothetical protein; Provisional; Region: PRK07236
479433000314	prephenate dehydratase; Provisional; Region: PRK11898
479433000315	Prephenate dehydratase; Region: PDT; pfam00800
479433000316	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
479433000317	putative L-Phe binding site [chemical binding]; other site
479433000318	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
479433000319	HSP70 interaction site [polypeptide binding]; other site
479433000320	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
479433000321	putative active site [active]
479433000322	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
479433000323	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
479433000324	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
479433000325	'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The...; Region: SANT; cl17250
479433000326	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
479433000327	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
479433000328	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
479433000329	phosphopeptide binding site; other site
479433000330	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172
479433000331	serpin-like protein; Provisional; Region: PHA02660
479433000332	reactive center loop; other site
479433000333	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
479433000334	FMN binding site [chemical binding]; other site
479433000335	dimer interface [polypeptide binding]; other site
479433000336	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
479433000337	PAS fold; Region: PAS; pfam00989
479433000338	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
479433000339	putative active site [active]
479433000340	heme pocket [chemical binding]; other site
479433000341	GAF domain; Region: GAF; cl17456
479433000342	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
479433000343	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
479433000344	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
479433000345	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
479433000346	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
479433000347	metal binding site [ion binding]; metal-binding site
479433000348	active site
479433000349	I-site; other site
479433000350	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
479433000351	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
479433000352	active site
479433000353	tetramer interface; other site
479433000354	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
479433000355	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
479433000356	dimer interface [polypeptide binding]; other site
479433000357	putative functional site; other site
479433000358	putative MPT binding site; other site
479433000359	molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364
479433000360	trimer interface [polypeptide binding]; other site
479433000361	dimer interface [polypeptide binding]; other site
479433000362	putative active site [active]
479433000363	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433000364	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433000365	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
479433000366	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
479433000367	iron-sulfur cluster [ion binding]; other site
479433000368	[2Fe-2S] cluster binding site [ion binding]; other site
479433000369	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
479433000370	active site
479433000371	oxyanion hole [active]
479433000372	MarR family; Region: MarR_2; cl17246
479433000373	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433000374	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
479433000375	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433000376	S-adenosylmethionine binding site [chemical binding]; other site
479433000377	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
479433000378	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433000379	dimer interface [polypeptide binding]; other site
479433000380	putative metal binding site [ion binding]; other site
479433000381	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
479433000382	PRC-barrel domain; Region: PRC; pfam05239
479433000383	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
479433000384	MgtE intracellular N domain; Region: MgtE_N; smart00924
479433000385	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
479433000386	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
479433000387	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433000388	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433000389	DNA binding residues [nucleotide binding]
479433000390	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
479433000391	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167
479433000392	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
479433000393	putative ligand binding site [chemical binding]; other site
479433000394	putative NAD binding site [chemical binding]; other site
479433000395	catalytic site [active]
479433000396	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
479433000397	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
479433000398	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433000399	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433000400	conserved gate region; other site
479433000401	putative PBP binding loops; other site
479433000402	ABC-ATPase subunit interface; other site
479433000403	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433000404	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
479433000405	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022
479433000406	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
479433000407	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
479433000408	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433000409	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433000410	DNA binding site [nucleotide binding]
479433000411	domain linker motif; other site
479433000412	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433000413	dimerization interface [polypeptide binding]; other site
479433000414	ligand binding site [chemical binding]; other site
479433000415	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433000416	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433000417	DNA binding residues [nucleotide binding]
479433000418	dimerization interface [polypeptide binding]; other site
479433000419	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
479433000420	Protein of unknown function (DUF993); Region: DUF993; pfam06187
479433000421	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
479433000422	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
479433000423	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433000424	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433000425	DNA binding site [nucleotide binding]
479433000426	domain linker motif; other site
479433000427	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433000428	dimerization interface [polypeptide binding]; other site
479433000429	ligand binding site [chemical binding]; other site
479433000430	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
479433000431	Response regulator receiver domain; Region: Response_reg; pfam00072
479433000432	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433000433	active site
479433000434	phosphorylation site [posttranslational modification]
479433000435	intermolecular recognition site; other site
479433000436	dimerization interface [polypeptide binding]; other site
479433000437	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
479433000438	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433000439	dimerization interface [polypeptide binding]; other site
479433000440	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433000441	dimerization interface [polypeptide binding]; other site
479433000442	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433000443	dimerization interface [polypeptide binding]; other site
479433000444	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433000445	dimerization interface [polypeptide binding]; other site
479433000446	GAF domain; Region: GAF_2; pfam13185
479433000447	GAF domain; Region: GAF; pfam01590
479433000448	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
479433000449	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433000450	dimer interface [polypeptide binding]; other site
479433000451	phosphorylation site [posttranslational modification]
479433000452	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433000453	ATP binding site [chemical binding]; other site
479433000454	Mg2+ binding site [ion binding]; other site
479433000455	G-X-G motif; other site
479433000456	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
479433000457	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433000458	active site
479433000459	phosphorylation site [posttranslational modification]
479433000460	intermolecular recognition site; other site
479433000461	dimerization interface [polypeptide binding]; other site
479433000462	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
479433000463	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
479433000464	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433000465	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433000466	DNA binding residues [nucleotide binding]
479433000467	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
479433000468	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433000469	S-adenosylmethionine binding site [chemical binding]; other site
479433000470	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
479433000471	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
479433000472	YcfA-like protein; Region: YcfA; pfam07927
479433000473	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
479433000474	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
479433000475	exopolyphosphatase; Region: exo_poly_only; TIGR03706
479433000476	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
479433000477	Protein of unknown function (DUF501); Region: DUF501; cl00652
479433000478	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
479433000479	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
479433000480	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
479433000481	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
479433000482	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
479433000483	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433000484	Histidine kinase; Region: HisKA_3; pfam07730
479433000485	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
479433000486	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
479433000487	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433000488	homodimer interface [polypeptide binding]; other site
479433000489	catalytic residue [active]
479433000490	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
479433000491	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
479433000492	conserved cys residue [active]
479433000493	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433000494	DJ-1 family protein; Region: not_thiJ; TIGR01383
479433000495	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
479433000496	conserved cys residue [active]
479433000497	short chain dehydrogenase; Provisional; Region: PRK06523
479433000498	classical (c) SDRs; Region: SDR_c; cd05233
479433000499	NAD(P) binding site [chemical binding]; other site
479433000500	active site
479433000501	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
479433000502	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
479433000503	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
479433000504	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
479433000505	ATP-grasp domain; Region: ATP-grasp_4; cl17255
479433000506	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
479433000507	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
479433000508	carboxyltransferase (CT) interaction site; other site
479433000509	biotinylation site [posttranslational modification]; other site
479433000510	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433000511	acyl-activating enzyme (AAE) consensus motif; other site
479433000512	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433000513	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433000514	Fatty acid desaturase; Region: FA_desaturase; pfam00487
479433000515	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
479433000516	Di-iron ligands [ion binding]; other site
479433000517	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
479433000518	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
479433000519	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
479433000520	Substrate binding site; other site
479433000521	Mg++ binding site; other site
479433000522	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
479433000523	active site
479433000524	substrate binding site [chemical binding]; other site
479433000525	CoA binding site [chemical binding]; other site
479433000526	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
479433000527	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
479433000528	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
479433000529	active site
479433000530	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
479433000531	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
479433000532	5S rRNA interface [nucleotide binding]; other site
479433000533	CTC domain interface [polypeptide binding]; other site
479433000534	L16 interface [polypeptide binding]; other site
479433000535	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
479433000536	putative active site [active]
479433000537	catalytic residue [active]
479433000538	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433000539	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
479433000540	Walker A/P-loop; other site
479433000541	ATP binding site [chemical binding]; other site
479433000542	Q-loop/lid; other site
479433000543	ABC transporter signature motif; other site
479433000544	Walker B; other site
479433000545	D-loop; other site
479433000546	H-loop/switch region; other site
479433000547	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
479433000548	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433000549	Histidine kinase; Region: HisKA_3; pfam07730
479433000550	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433000551	ATP binding site [chemical binding]; other site
479433000552	Mg2+ binding site [ion binding]; other site
479433000553	G-X-G motif; other site
479433000554	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433000555	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433000556	active site
479433000557	phosphorylation site [posttranslational modification]
479433000558	intermolecular recognition site; other site
479433000559	dimerization interface [polypeptide binding]; other site
479433000560	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433000561	DNA binding residues [nucleotide binding]
479433000562	dimerization interface [polypeptide binding]; other site
479433000563	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
479433000564	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
479433000565	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
479433000566	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
479433000567	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
479433000568	Catalytic site [active]
479433000569	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
479433000570	Phosphoesterase family; Region: Phosphoesterase; pfam04185
479433000571	Domain of unknown function (DUF756); Region: DUF756; pfam05506
479433000572	Domain of unknown function (DUF756); Region: DUF756; pfam05506
479433000573	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
479433000574	Uncharacterized conserved protein [Function unknown]; Region: COG2128
479433000575	A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414
479433000576	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
479433000577	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
479433000578	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
479433000579	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
479433000580	ATP binding site [chemical binding]; other site
479433000581	putative Mg++ binding site [ion binding]; other site
479433000582	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
479433000583	nucleotide binding region [chemical binding]; other site
479433000584	ATP-binding site [chemical binding]; other site
479433000585	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
479433000586	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433000587	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433000588	putative substrate translocation pore; other site
479433000589	Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790
479433000590	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
479433000591	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
479433000592	homodimer interface [polypeptide binding]; other site
479433000593	metal binding site [ion binding]; metal-binding site
479433000594	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
479433000595	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
479433000596	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
479433000597	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433000598	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433000599	active site
479433000600	phosphorylation site [posttranslational modification]
479433000601	intermolecular recognition site; other site
479433000602	dimerization interface [polypeptide binding]; other site
479433000603	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433000604	DNA binding residues [nucleotide binding]
479433000605	dimerization interface [polypeptide binding]; other site
479433000606	Putative sensor; Region: Sensor; pfam13796
479433000607	Histidine kinase; Region: HisKA_3; pfam07730
479433000608	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433000609	ATP binding site [chemical binding]; other site
479433000610	Mg2+ binding site [ion binding]; other site
479433000611	G-X-G motif; other site
479433000612	Clp amino terminal domain; Region: Clp_N; pfam02861
479433000613	Clp amino terminal domain; Region: Clp_N; pfam02861
479433000614	enolase; Provisional; Region: eno; PRK00077
479433000615	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
479433000616	dimer interface [polypeptide binding]; other site
479433000617	metal binding site [ion binding]; metal-binding site
479433000618	substrate binding pocket [chemical binding]; other site
479433000619	Septum formation initiator; Region: DivIC; pfam04977
479433000620	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433000621	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433000622	active site
479433000623	phosphorylation site [posttranslational modification]
479433000624	intermolecular recognition site; other site
479433000625	dimerization interface [polypeptide binding]; other site
479433000626	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433000627	DNA binding residues [nucleotide binding]
479433000628	dimerization interface [polypeptide binding]; other site
479433000629	Putative sensor; Region: Sensor; pfam13796
479433000630	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433000631	Histidine kinase; Region: HisKA_3; pfam07730
479433000632	acyl-CoA synthetase; Provisional; Region: PRK13388
479433000633	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433000634	acyl-activating enzyme (AAE) consensus motif; other site
479433000635	AMP binding site [chemical binding]; other site
479433000636	active site
479433000637	CoA binding site [chemical binding]; other site
479433000638	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433000639	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433000640	dimerization interface [polypeptide binding]; other site
479433000641	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433000642	dimer interface [polypeptide binding]; other site
479433000643	phosphorylation site [posttranslational modification]
479433000644	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433000645	ATP binding site [chemical binding]; other site
479433000646	Mg2+ binding site [ion binding]; other site
479433000647	G-X-G motif; other site
479433000648	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433000649	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433000650	active site
479433000651	phosphorylation site [posttranslational modification]
479433000652	intermolecular recognition site; other site
479433000653	dimerization interface [polypeptide binding]; other site
479433000654	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433000655	DNA binding site [nucleotide binding]
479433000656	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
479433000657	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
479433000658	FtsX-like permease family; Region: FtsX; pfam02687
479433000659	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
479433000660	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
479433000661	Walker A/P-loop; other site
479433000662	ATP binding site [chemical binding]; other site
479433000663	Q-loop/lid; other site
479433000664	ABC transporter signature motif; other site
479433000665	Walker B; other site
479433000666	D-loop; other site
479433000667	H-loop/switch region; other site
479433000668	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
479433000669	HlyD family secretion protein; Region: HlyD_3; pfam13437
479433000670	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
479433000671	catalytic triad [active]
479433000672	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
479433000673	translocation protein TolB; Provisional; Region: tolB; PRK00178
479433000674	translocation protein TolB; Provisional; Region: tolB; PRK05137
479433000675	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433000676	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433000677	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
479433000678	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433000679	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433000680	Transposase, Mutator family; Region: Transposase_mut; pfam00872
479433000681	MULE transposase domain; Region: MULE; pfam10551
479433000682	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433000683	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433000684	non-specific DNA binding site [nucleotide binding]; other site
479433000685	salt bridge; other site
479433000686	sequence-specific DNA binding site [nucleotide binding]; other site
479433000687	NB-ARC domain; Region: NB-ARC; pfam00931
479433000688	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433000689	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433000690	binding surface
479433000691	TPR motif; other site
479433000692	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433000693	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433000694	TIR domain; Region: TIR_2; cl17458
479433000695	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433000696	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433000697	non-specific DNA binding site [nucleotide binding]; other site
479433000698	salt bridge; other site
479433000699	sequence-specific DNA binding site [nucleotide binding]; other site
479433000700	NACHT domain; Region: NACHT; pfam05729
479433000701	TIR domain; Region: TIR_2; cl17458
479433000702	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433000703	Tetratricopeptide repeat; Region: TPR_10; pfam13374
479433000704	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433000705	Tetratricopeptide repeat; Region: TPR_10; pfam13374
479433000706	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433000707	sequence-specific DNA binding site [nucleotide binding]; other site
479433000708	salt bridge; other site
479433000709	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
479433000710	active site
479433000711	iron coordination sites [ion binding]; other site
479433000712	substrate binding pocket [chemical binding]; other site
479433000713	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
479433000714	thymidine kinase; Provisional; Region: PRK04296
479433000715	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
479433000716	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
479433000717	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
479433000718	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
479433000719	putative active site [active]
479433000720	catalytic site [active]
479433000721	putative metal binding site [ion binding]; other site
479433000722	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433000723	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433000724	ATP binding site [chemical binding]; other site
479433000725	Mg2+ binding site [ion binding]; other site
479433000726	G-X-G motif; other site
479433000727	chorismate binding enzyme; Region: Chorismate_bind; cl10555
479433000728	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
479433000729	Glutamine amidotransferase class-I; Region: GATase; pfam00117
479433000730	glutamine binding [chemical binding]; other site
479433000731	catalytic triad [active]
479433000732	SEC-C motif; Region: SEC-C; pfam02810
479433000733	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433000734	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433000735	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
479433000736	active site residue [active]
479433000737	seryl-tRNA synthetase; Provisional; Region: PRK05431
479433000738	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
479433000739	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
479433000740	dimer interface [polypeptide binding]; other site
479433000741	active site
479433000742	motif 1; other site
479433000743	motif 2; other site
479433000744	motif 3; other site
479433000745	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
479433000746	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433000747	DNA binding residues [nucleotide binding]
479433000748	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433000749	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
479433000750	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433000751	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433000752	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433000753	imidazolonepropionase; Provisional; Region: PRK14085
479433000754	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
479433000755	active site
479433000756	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
479433000757	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
479433000758	active site
479433000759	allantoate amidohydrolase; Reviewed; Region: PRK09290
479433000760	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
479433000761	active site
479433000762	metal binding site [ion binding]; metal-binding site
479433000763	dimer interface [polypeptide binding]; other site
479433000764	urocanate hydratase; Provisional; Region: PRK05414
479433000765	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
479433000766	active sites [active]
479433000767	tetramer interface [polypeptide binding]; other site
479433000768	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433000769	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433000770	dimerization interface [polypeptide binding]; other site
479433000771	putative DNA binding site [nucleotide binding]; other site
479433000772	putative Zn2+ binding site [ion binding]; other site
479433000773	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
479433000774	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
479433000775	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
479433000776	putative active site [active]
479433000777	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
479433000778	4Fe-4S binding domain; Region: Fer4; pfam00037
479433000779	Cysteine-rich domain; Region: CCG; pfam02754
479433000780	Cysteine-rich domain; Region: CCG; pfam02754
479433000781	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433000782	non-specific DNA binding site [nucleotide binding]; other site
479433000783	salt bridge; other site
479433000784	sequence-specific DNA binding site [nucleotide binding]; other site
479433000785	Domain of unknown function (DUF397); Region: DUF397; pfam04149
479433000786	Domain of unknown function (DUF397); Region: DUF397; pfam04149
479433000787	HSP90 family protein; Provisional; Region: PRK14083
479433000788	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433000789	Mg2+ binding site [ion binding]; other site
479433000790	G-X-G motif; other site
479433000791	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433000792	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433000793	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433000794	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433000795	DNA binding residues [nucleotide binding]
479433000796	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
479433000797	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
479433000798	GDP-binding site [chemical binding]; other site
479433000799	ACT binding site; other site
479433000800	IMP binding site; other site
479433000801	hypothetical protein; Provisional; Region: PRK06062
479433000802	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
479433000803	inhibitor-cofactor binding pocket; inhibition site
479433000804	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433000805	catalytic residue [active]
479433000806	transcription termination factor Rho; Provisional; Region: PRK12678
479433000807	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433000808	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433000809	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433000810	Isochorismatase family; Region: Isochorismatase; pfam00857
479433000811	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
479433000812	catalytic triad [active]
479433000813	conserved cis-peptide bond; other site
479433000814	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433000815	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433000816	putative substrate translocation pore; other site
479433000817	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433000818	MarR family; Region: MarR; pfam01047
479433000819	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
479433000820	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
479433000821	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
479433000822	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
479433000823	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433000824	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433000825	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433000826	DNA binding residues [nucleotide binding]
479433000827	adenylosuccinate lyase; Provisional; Region: PRK07492
479433000828	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
479433000829	tetramer interface [polypeptide binding]; other site
479433000830	active site
479433000831	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
479433000832	HicB family; Region: HicB; pfam05534
479433000833	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433000834	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
479433000835	Walker A/P-loop; other site
479433000836	ATP binding site [chemical binding]; other site
479433000837	Q-loop/lid; other site
479433000838	ABC transporter signature motif; other site
479433000839	Walker B; other site
479433000840	D-loop; other site
479433000841	H-loop/switch region; other site
479433000842	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
479433000843	ATP binding site [chemical binding]; other site
479433000844	active site
479433000845	substrate binding site [chemical binding]; other site
479433000846	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
479433000847	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
479433000848	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
479433000849	putative active site [active]
479433000850	catalytic triad [active]
479433000851	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
479433000852	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
479433000853	dimerization interface [polypeptide binding]; other site
479433000854	ATP binding site [chemical binding]; other site
479433000855	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
479433000856	dimerization interface [polypeptide binding]; other site
479433000857	ATP binding site [chemical binding]; other site
479433000858	HEAT repeats; Region: HEAT_2; pfam13646
479433000859	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
479433000860	amidophosphoribosyltransferase; Provisional; Region: PRK07847
479433000861	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
479433000862	active site
479433000863	tetramer interface [polypeptide binding]; other site
479433000864	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
479433000865	active site
479433000866	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
479433000867	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
479433000868	dimerization interface [polypeptide binding]; other site
479433000869	putative ATP binding site [chemical binding]; other site
479433000870	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
479433000871	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
479433000872	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
479433000873	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
479433000874	NAD binding site [chemical binding]; other site
479433000875	Phe binding site; other site
479433000876	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
479433000877	DNA binding residues [nucleotide binding]
479433000878	Cellulose binding domain; Region: CBM_2; pfam00553
479433000879	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
479433000880	active site
479433000881	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
479433000882	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
479433000883	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
479433000884	Penicillinase repressor; Region: Pencillinase_R; cl17580
479433000885	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
479433000886	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
479433000887	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
479433000888	active site
479433000889	metal binding site [ion binding]; metal-binding site
479433000890	MMPL family; Region: MMPL; pfam03176
479433000891	MMPL family; Region: MMPL; pfam03176
479433000892	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433000893	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433000894	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433000895	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433000896	LysR substrate binding domain; Region: LysR_substrate; pfam03466
479433000897	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
479433000898	TfoX C-terminal domain; Region: TfoX_C; pfam04994
479433000899	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
479433000900	MPN+ (JAMM) motif; other site
479433000901	Zinc-binding site [ion binding]; other site
479433000902	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
479433000903	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433000904	putative substrate translocation pore; other site
479433000905	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433000906	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433000907	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433000908	S-adenosylmethionine binding site [chemical binding]; other site
479433000909	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
479433000910	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433000911	Predicted transcriptional regulators [Transcription]; Region: COG1733
479433000912	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
479433000913	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
479433000914	putative hydrophobic ligand binding site [chemical binding]; other site
479433000915	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
479433000916	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
479433000917	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
479433000918	TROVE domain; Region: TROVE; pfam05731
479433000919	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
479433000920	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433000921	putative substrate translocation pore; other site
479433000922	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433000923	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433000924	MarR family; Region: MarR_2; pfam12802
479433000925	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
479433000926	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
479433000927	Predicted transcriptional regulator [Transcription]; Region: COG2378
479433000928	HTH domain; Region: HTH_11; pfam08279
479433000929	WYL domain; Region: WYL; pfam13280
479433000930	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433000931	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
479433000932	active site
479433000933	metal binding site [ion binding]; metal-binding site
479433000934	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433000935	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433000936	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433000937	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
479433000938	putative NAD(P) binding site [chemical binding]; other site
479433000939	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
479433000940	nudix motif; other site
479433000941	replicative DNA helicase; Region: DnaB; TIGR00665
479433000942	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
479433000943	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
479433000944	Walker A motif; other site
479433000945	ATP binding site [chemical binding]; other site
479433000946	Walker B motif; other site
479433000947	DNA binding loops [nucleotide binding]
479433000948	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
479433000949	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
479433000950	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
479433000951	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
479433000952	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
479433000953	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
479433000954	dimer interface [polypeptide binding]; other site
479433000955	ssDNA binding site [nucleotide binding]; other site
479433000956	tetramer (dimer of dimers) interface [polypeptide binding]; other site
479433000957	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
479433000958	endonuclease IV; Provisional; Region: PRK01060
479433000959	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
479433000960	AP (apurinic/apyrimidinic) site pocket; other site
479433000961	DNA interaction; other site
479433000962	Metal-binding active site; metal-binding site
479433000963	FemAB family; Region: FemAB; pfam02388
479433000964	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
479433000965	Alanine racemase, N-terminal domain; Region: Ala_racemase_N; pfam01168
479433000966	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
479433000967	catalytic residue [active]
479433000968	Predicted integral membrane protein [Function unknown]; Region: COG5650
479433000969	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
479433000970	Transglycosylase; Region: Transgly; pfam00912
479433000971	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
479433000972	Predicted transcriptional regulators [Transcription]; Region: COG1695
479433000973	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
479433000974	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
479433000975	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
479433000976	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433000977	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433000978	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433000979	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
479433000980	Predicted transcriptional regulator [Transcription]; Region: COG1959
479433000981	Transcriptional regulator; Region: Rrf2; pfam02082
479433000982	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
479433000983	peptidase domain interface [polypeptide binding]; other site
479433000984	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
479433000985	active site
479433000986	catalytic triad [active]
479433000987	calcium binding site [ion binding]; other site
479433000988	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
479433000989	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433000990	putative substrate translocation pore; other site
479433000991	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
479433000992	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
479433000993	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
479433000994	AsnC family; Region: AsnC_trans_reg; pfam01037
479433000995	Transcriptional regulator; Region: Rrf2; pfam02082
479433000996	Predicted transcriptional regulator [Transcription]; Region: COG1959
479433000997	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
479433000998	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
479433000999	heme-binding site [chemical binding]; other site
479433001000	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
479433001001	FAD binding pocket [chemical binding]; other site
479433001002	FAD binding motif [chemical binding]; other site
479433001003	phosphate binding motif [ion binding]; other site
479433001004	beta-alpha-beta structure motif; other site
479433001005	NAD binding pocket [chemical binding]; other site
479433001006	Heme binding  pocket [chemical binding]; other site
479433001007	vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556
479433001008	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
479433001009	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433001010	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
479433001011	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
479433001012	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433001013	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433001014	ATP binding site [chemical binding]; other site
479433001015	Mg2+ binding site [ion binding]; other site
479433001016	G-X-G motif; other site
479433001017	Roadblock/LC7 domain; Region: Robl_LC7; pfam03259
479433001018	Protein of unknown function (DUF742); Region: DUF742; pfam05331
479433001019	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
479433001020	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
479433001021	G1 box; other site
479433001022	GTP/Mg2+ binding site [chemical binding]; other site
479433001023	G2 box; other site
479433001024	Switch I region; other site
479433001025	G3 box; other site
479433001026	Switch II region; other site
479433001027	G4 box; other site
479433001028	G5 box; other site
479433001029	GAF domain; Region: GAF; pfam01590
479433001030	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
479433001031	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
479433001032	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
479433001033	dimer interface [polypeptide binding]; other site
479433001034	active site
479433001035	CoA binding pocket [chemical binding]; other site
479433001036	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
479433001037	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433001038	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
479433001039	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
479433001040	active site
479433001041	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
479433001042	Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576
479433001043	putative ligand binding site [chemical binding]; other site
479433001044	putative catalytic site [active]
479433001045	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433001046	sugar binding site [chemical binding]; other site
479433001047	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
479433001048	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433001049	sugar binding site [chemical binding]; other site
479433001050	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433001051	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433001052	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
479433001053	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
479433001054	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433001055	NAD(P) binding site [chemical binding]; other site
479433001056	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
479433001057	MarR family; Region: MarR_2; pfam12802
479433001058	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
479433001059	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
479433001060	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433001061	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433001062	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273
479433001063	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433001064	putative NAD(P) binding site [chemical binding]; other site
479433001065	SnoaL-like domain; Region: SnoaL_2; pfam12680
479433001066	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
479433001067	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433001068	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
479433001069	dimerization interface [polypeptide binding]; other site
479433001070	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
479433001071	putative Iron-sulfur protein interface [polypeptide binding]; other site
479433001072	proximal heme binding site [chemical binding]; other site
479433001073	distal heme binding site [chemical binding]; other site
479433001074	putative dimer interface [polypeptide binding]; other site
479433001075	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
479433001076	L-aspartate oxidase; Provisional; Region: PRK06175
479433001077	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
479433001078	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
479433001079	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
479433001080	4Fe-4S binding domain; Region: Fer4; pfam00037
479433001081	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
479433001082	active site
479433001083	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
479433001084	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433001085	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433001086	FMN-binding domain; Region: FMN_bind; pfam04205
479433001087	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
479433001088	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
479433001089	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
479433001090	FAD binding pocket [chemical binding]; other site
479433001091	conserved FAD binding motif [chemical binding]; other site
479433001092	phosphate binding motif [ion binding]; other site
479433001093	beta-alpha-beta structure motif; other site
479433001094	NAD binding pocket [chemical binding]; other site
479433001095	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
479433001096	hydrophobic ligand binding site; other site
479433001097	RNA polymerase factor sigma-70; Validated; Region: PRK08241
479433001098	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433001099	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433001100	DNA binding residues [nucleotide binding]
479433001101	SnoaL-like domain; Region: SnoaL_2; pfam12680
479433001102	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
479433001103	Domain of unknown function (DUF336); Region: DUF336; pfam03928
479433001104	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433001105	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433001106	non-specific DNA binding site [nucleotide binding]; other site
479433001107	salt bridge; other site
479433001108	sequence-specific DNA binding site [nucleotide binding]; other site
479433001109	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
479433001110	Domain of unknown function (DUF239); Region: DUF239; pfam03080
479433001111	Domain of unknown function (DUF239); Region: DUF239; pfam03080
479433001112	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433001113	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433001114	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
479433001115	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433001116	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433001117	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433001118	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433001119	short chain dehydrogenase; Validated; Region: PRK07069
479433001120	NAD(P) binding site [chemical binding]; other site
479433001121	active site
479433001122	MgtC family; Region: MgtC; pfam02308
479433001123	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433001124	putative substrate translocation pore; other site
479433001125	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433001126	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433001127	sequence-specific DNA binding site [nucleotide binding]; other site
479433001128	salt bridge; other site
479433001129	DinB superfamily; Region: DinB_2; pfam12867
479433001130	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433001131	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433001132	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433001133	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
479433001134	NAD(P) binding site [chemical binding]; other site
479433001135	active site
479433001136	tetracycline repressor protein TetR; Provisional; Region: PRK13756
479433001137	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433001138	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
479433001139	DEAD-like helicases superfamily; Region: DEXDc; smart00487
479433001140	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
479433001141	ATP binding site [chemical binding]; other site
479433001142	putative Mg++ binding site [ion binding]; other site
479433001143	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
479433001144	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
479433001145	nucleotide binding region [chemical binding]; other site
479433001146	ATP-binding site [chemical binding]; other site
479433001147	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
479433001148	active site
479433001149	catalytic triad [active]
479433001150	calcium binding site [ion binding]; other site
479433001151	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
479433001152	active site
479433001153	catalytic triad [active]
479433001154	calcium binding site [ion binding]; other site
479433001155	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433001156	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433001157	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433001158	DNA binding residues [nucleotide binding]
479433001159	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
479433001160	iron-sulfur cluster [ion binding]; other site
479433001161	[2Fe-2S] cluster binding site [ion binding]; other site
479433001162	Protein kinase domain; Region: Pkinase; pfam00069
479433001163	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433001164	active site
479433001165	ATP binding site [chemical binding]; other site
479433001166	substrate binding site [chemical binding]; other site
479433001167	activation loop (A-loop); other site
479433001168	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
479433001169	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
479433001170	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
479433001171	Oxidoreductase molybdopterin binding domain; Region: Oxidored_molyb; pfam00174
479433001172	Moco binding site; other site
479433001173	metal coordination site [ion binding]; other site
479433001174	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433001175	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
479433001176	Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829
479433001177	active site
479433001178	putative catalytic site [active]
479433001179	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
479433001180	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433001181	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433001182	DNA binding residues [nucleotide binding]
479433001183	3D domain; Region: 3D; cl01439
479433001184	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
479433001185	aromatic chitin/cellulose binding site residues [chemical binding]; other site
479433001186	Cellulose binding domain; Region: CBM_2; pfam00553
479433001187	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
479433001188	Interdomain contacts; other site
479433001189	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
479433001190	active site
479433001191	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433001192	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433001193	Tetratricopeptide repeat; Region: TPR_10; pfam13374
479433001194	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433001195	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433001196	Tetratricopeptide repeat; Region: TPR_10; pfam13374
479433001197	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433001198	Tetratricopeptide repeat; Region: TPR_10; pfam13374
479433001199	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
479433001200	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433001201	Walker A motif; other site
479433001202	ATP binding site [chemical binding]; other site
479433001203	Walker B motif; other site
479433001204	radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269
479433001205	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433001206	FeS/SAM binding site; other site
479433001207	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
479433001208	AAA ATPase domain; Region: AAA_16; pfam13191
479433001209	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433001210	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433001211	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433001212	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433001213	binding surface
479433001214	TPR motif; other site
479433001215	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433001216	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433001217	Ricin-type beta-trefoil; Region: RICIN; smart00458
479433001218	putative sugar binding sites [chemical binding]; other site
479433001219	Q-X-W motif; other site
479433001220	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
479433001221	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
479433001222	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
479433001223	active site
479433001224	catalytic residues [active]
479433001225	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
479433001226	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
479433001227	putative ligand binding site [chemical binding]; other site
479433001228	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
479433001229	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
479433001230	Walker A/P-loop; other site
479433001231	ATP binding site [chemical binding]; other site
479433001232	Q-loop/lid; other site
479433001233	ABC transporter signature motif; other site
479433001234	Walker B; other site
479433001235	D-loop; other site
479433001236	H-loop/switch region; other site
479433001237	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
479433001238	active site
479433001239	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
479433001240	PBP superfamily domain; Region: PBP_like_2; cl17296
479433001241	PBP superfamily domain; Region: PBP_like_2; cl17296
479433001242	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433001243	dimer interface [polypeptide binding]; other site
479433001244	conserved gate region; other site
479433001245	ABC-ATPase subunit interface; other site
479433001246	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
479433001247	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433001248	dimer interface [polypeptide binding]; other site
479433001249	conserved gate region; other site
479433001250	ABC-ATPase subunit interface; other site
479433001251	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
479433001252	Beta-lactamase; Region: Beta-lactamase; pfam00144
479433001253	endoglucanase; Region: PLN02420
479433001254	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759
479433001255	Cellulose binding domain; Region: CBM_3; smart01067
479433001256	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
479433001257	Interdomain contacts; other site
479433001258	Cellulose binding domain; Region: CBM_3; smart01067
479433001259	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402
479433001260	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433001261	domain linker motif; other site
479433001262	Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296
479433001263	putative ligand binding site [chemical binding]; other site
479433001264	putative dimerization interface [polypeptide binding]; other site
479433001265	Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457
479433001266	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433001267	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433001268	dimerization interface [polypeptide binding]; other site
479433001269	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433001270	dimer interface [polypeptide binding]; other site
479433001271	phosphorylation site [posttranslational modification]
479433001272	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433001273	ATP binding site [chemical binding]; other site
479433001274	Mg2+ binding site [ion binding]; other site
479433001275	G-X-G motif; other site
479433001276	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433001277	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433001278	active site
479433001279	phosphorylation site [posttranslational modification]
479433001280	intermolecular recognition site; other site
479433001281	dimerization interface [polypeptide binding]; other site
479433001282	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433001283	DNA binding site [nucleotide binding]
479433001284	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433001285	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433001286	active site
479433001287	phosphorylation site [posttranslational modification]
479433001288	intermolecular recognition site; other site
479433001289	dimerization interface [polypeptide binding]; other site
479433001290	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433001291	DNA binding site [nucleotide binding]
479433001292	HAMP domain; Region: HAMP; pfam00672
479433001293	dimerization interface [polypeptide binding]; other site
479433001294	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433001295	dimer interface [polypeptide binding]; other site
479433001296	phosphorylation site [posttranslational modification]
479433001297	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433001298	ATP binding site [chemical binding]; other site
479433001299	Mg2+ binding site [ion binding]; other site
479433001300	G-X-G motif; other site
479433001301	TAP-like protein; Region: Abhydrolase_4; pfam08386
479433001302	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
479433001303	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
479433001304	Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457
479433001305	Cellulose binding domain; Region: CBM_2; pfam00553
479433001306	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
479433001307	Catalytic NodB homology domain of Streptomyces lividans acetylxylan esterase and its bacterial homologs; Region: CE4_SlAXE_like; cd10953
479433001308	NodB motif; other site
479433001309	active site
479433001310	catalytic site [active]
479433001311	Zn binding site [ion binding]; other site
479433001312	dimer interface [polypeptide binding]; other site
479433001313	CBD_II domain; Region: CBD_II; smart00637
479433001314	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
479433001315	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
479433001316	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433001317	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433001318	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
479433001319	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
479433001320	active site
479433001321	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
479433001322	Cytochrome P450; Region: p450; cl12078
479433001323	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433001324	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
479433001325	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433001326	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433001327	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433001328	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433001329	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433001330	Restriction endonuclease; Region: Mrr_cat; pfam04471
479433001331	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
479433001332	TIGR02679 family protein; Region: TIGR02679
479433001333	Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664
479433001334	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
479433001335	Protein of unknown function (DUF2398); Region: DUF2398; pfam09661
479433001336	TIGR02677 family protein; Region: TIGR02677
479433001337	Protein of unknown function (DUF2397); Region: DUF2397; pfam09660
479433001338	TIR domain; Region: TIR_2; pfam13676
479433001339	FxsC C-terminal domain; Region: FxsC_Cterm; TIGR04276
479433001340	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
479433001341	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
479433001342	P-loop; other site
479433001343	Magnesium ion binding site [ion binding]; other site
479433001344	SEFIR domain; Region: SEFIR; pfam08357
479433001345	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
479433001346	Short C-terminal domain; Region: SHOCT; pfam09851
479433001347	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530
479433001348	metal binding site [ion binding]; metal-binding site
479433001349	Domain of unknown function (DUF955); Region: DUF955; cl01076
479433001350	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
479433001351	ADP-ribose binding site [chemical binding]; other site
479433001352	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
479433001353	AAA domain; Region: AAA_18; pfam13238
479433001354	active site
479433001355	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
479433001356	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
479433001357	Right handed beta helix region; Region: Beta_helix; pfam13229
479433001358	Right handed beta helix region; Region: Beta_helix; pfam13229
479433001359	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433001360	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433001361	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433001362	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
479433001363	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433001364	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433001365	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
479433001366	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433001367	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433001368	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
479433001369	TrkA-N domain; Region: TrkA_N; pfam02254
479433001370	RyR domain; Region: RyR; pfam02026
479433001371	radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269
479433001372	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433001373	FeS/SAM binding site; other site
479433001374	HEXXH motif domain; Region: mod_HExxH; TIGR04267
479433001375	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
479433001376	TIR domain; Region: TIR_2; pfam13676
479433001377	FxsC C-terminal domain; Region: FxsC_Cterm; TIGR04276
479433001378	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
479433001379	P-loop; other site
479433001380	Magnesium ion binding site [ion binding]; other site
479433001381	AAA ATPase domain; Region: AAA_16; pfam13191
479433001382	NB-ARC domain; Region: NB-ARC; pfam00931
479433001383	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433001384	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433001385	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433001386	Tetratricopeptide repeat; Region: TPR_10; pfam13374
479433001387	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433001388	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433001389	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433001390	Integrase core domain; Region: rve; pfam00665
479433001391	Integrase core domain; Region: rve_3; cl15866
479433001392	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
479433001393	putative active site [active]
479433001394	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
479433001395	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433001396	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
479433001397	catalytic site [active]
479433001398	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
479433001399	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
479433001400	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
479433001401	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
479433001402	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
479433001403	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
479433001404	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
479433001405	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
479433001406	hypothetical protein; Validated; Region: PRK07080
479433001407	Phosphopantetheine attachment site; Region: PP-binding; cl09936
479433001408	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
479433001409	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
479433001410	dinuclear metal binding motif [ion binding]; other site
479433001411	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
479433001412	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433001413	acyl-activating enzyme (AAE) consensus motif; other site
479433001414	AMP binding site [chemical binding]; other site
479433001415	active site
479433001416	CoA binding site [chemical binding]; other site
479433001417	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433001418	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433001419	putative substrate translocation pore; other site
479433001420	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433001421	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433001422	putative DNA binding site [nucleotide binding]; other site
479433001423	putative Zn2+ binding site [ion binding]; other site
479433001424	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
479433001425	putative dimerization interface [polypeptide binding]; other site
479433001426	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
479433001427	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
479433001428	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433001429	catalytic residue [active]
479433001430	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
479433001431	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
479433001432	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433001433	FeS/SAM binding site; other site
479433001434	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433001435	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433001436	putative substrate translocation pore; other site
479433001437	selenophosphate synthetase; Provisional; Region: PRK00943
479433001438	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
479433001439	dimerization interface [polypeptide binding]; other site
479433001440	putative ATP binding site [chemical binding]; other site
479433001441	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433001442	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
479433001443	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
479433001444	active site
479433001445	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
479433001446	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
479433001447	putative transposase OrfB; Reviewed; Region: PHA02517
479433001448	Integrase core domain; Region: rve; pfam00665
479433001449	Integrase core domain; Region: rve_3; cl15866
479433001450	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
479433001451	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
479433001452	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433001453	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
479433001454	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433001455	MarR family; Region: MarR_2; pfam12802
479433001456	YCII-related domain; Region: YCII; cl00999
479433001457	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433001458	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
479433001459	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
479433001460	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433001461	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
479433001462	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433001463	S-adenosylmethionine binding site [chemical binding]; other site
479433001464	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
479433001465	ATP binding site [chemical binding]; other site
479433001466	substrate interface [chemical binding]; other site
479433001467	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
479433001468	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
479433001469	dimer interface [polypeptide binding]; other site
479433001470	active site
479433001471	CoA binding pocket [chemical binding]; other site
479433001472	LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037
479433001473	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
479433001474	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
479433001475	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433001476	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
479433001477	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
479433001478	Domain of unknown function (DUF718); Region: DUF718; cl01281
479433001479	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
479433001480	Amidohydrolase; Region: Amidohydro_2; pfam04909
479433001481	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
479433001482	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
479433001483	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433001484	S-adenosylmethionine binding site [chemical binding]; other site
479433001485	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
479433001486	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
479433001487	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
479433001488	heme-binding site [chemical binding]; other site
479433001489	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
479433001490	FAD binding pocket [chemical binding]; other site
479433001491	conserved FAD binding motif [chemical binding]; other site
479433001492	phosphate binding motif [ion binding]; other site
479433001493	beta-alpha-beta structure motif; other site
479433001494	NAD binding pocket [chemical binding]; other site
479433001495	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
479433001496	heme-binding site [chemical binding]; other site
479433001497	Peptidase family M48; Region: Peptidase_M48; cl12018
479433001498	Protein of unknown function (DUF4237); Region: DUF4237; pfam14021
479433001499	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433001500	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
479433001501	Predicted methyltransferases [General function prediction only]; Region: COG0313
479433001502	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
479433001503	putative SAM binding site [chemical binding]; other site
479433001504	putative homodimer interface [polypeptide binding]; other site
479433001505	Fic/DOC family; Region: Fic; cl00960
479433001506	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
479433001507	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
479433001508	active site
479433001509	HIGH motif; other site
479433001510	KMSKS motif; other site
479433001511	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
479433001512	tRNA binding surface [nucleotide binding]; other site
479433001513	anticodon binding site; other site
479433001514	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
479433001515	active site
479433001516	Domain of unknown function (DUF348); Region: DUF348; pfam03990
479433001517	Domain of unknown function (DUF348); Region: DUF348; pfam03990
479433001518	Domain of unknown function (DUF348); Region: DUF348; pfam03990
479433001519	G5 domain; Region: G5; pfam07501
479433001520	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
479433001521	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
479433001522	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
479433001523	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
479433001524	Protein kinase domain; Region: Pkinase; pfam00069
479433001525	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433001526	active site
479433001527	ATP binding site [chemical binding]; other site
479433001528	substrate binding site [chemical binding]; other site
479433001529	activation loop (A-loop); other site
479433001530	PQQ-like domain; Region: PQQ_2; pfam13360
479433001531	yiaA/B two helix domain; Region: YiaAB; cl01759
479433001532	MgtC family; Region: MgtC; pfam02308
479433001533	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
479433001534	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
479433001535	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433001536	catalytic residue [active]
479433001537	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
479433001538	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
479433001539	metal binding site [ion binding]; metal-binding site
479433001540	active site
479433001541	I-site; other site
479433001542	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
479433001543	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
479433001544	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
479433001545	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
479433001546	MoxR-like ATPases [General function prediction only]; Region: COG0714
479433001547	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
479433001548	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
479433001549	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
479433001550	metal ion-dependent adhesion site (MIDAS); other site
479433001551	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
479433001552	PAS domain; Region: PAS_9; pfam13426
479433001553	putative active site [active]
479433001554	heme pocket [chemical binding]; other site
479433001555	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433001556	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433001557	ATP binding site [chemical binding]; other site
479433001558	Mg2+ binding site [ion binding]; other site
479433001559	G-X-G motif; other site
479433001560	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433001561	active site
479433001562	phosphorylation site [posttranslational modification]
479433001563	intermolecular recognition site; other site
479433001564	Phosphoesterase family; Region: Phosphoesterase; pfam04185
479433001565	Predicted amidohydrolase [General function prediction only]; Region: COG0388
479433001566	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
479433001567	active site
479433001568	catalytic triad [active]
479433001569	dimer interface [polypeptide binding]; other site
479433001570	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
479433001571	DoxX-like family; Region: DoxX_2; pfam13564
479433001572	Putative sensor; Region: Sensor; pfam13796
479433001573	Histidine kinase; Region: HisKA_3; pfam07730
479433001574	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
479433001575	ATP binding site [chemical binding]; other site
479433001576	Mg2+ binding site [ion binding]; other site
479433001577	G-X-G motif; other site
479433001578	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433001579	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433001580	active site
479433001581	phosphorylation site [posttranslational modification]
479433001582	intermolecular recognition site; other site
479433001583	dimerization interface [polypeptide binding]; other site
479433001584	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433001585	DNA binding residues [nucleotide binding]
479433001586	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433001587	NADH(P)-binding; Region: NAD_binding_10; pfam13460
479433001588	NAD(P) binding site [chemical binding]; other site
479433001589	active site
479433001590	Rrf2 family protein; Region: rrf2_super; TIGR00738
479433001591	Transcriptional regulator; Region: Rrf2; pfam02082
479433001592	Transcriptional regulator; Region: Rrf2; cl17282
479433001593	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
479433001594	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433001595	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433001596	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
479433001597	substrate binding pocket [chemical binding]; other site
479433001598	dimerization interface [polypeptide binding]; other site
479433001599	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
479433001600	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
479433001601	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433001602	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433001603	DNA binding site [nucleotide binding]
479433001604	domain linker motif; other site
479433001605	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433001606	dimerization interface [polypeptide binding]; other site
479433001607	ligand binding site [chemical binding]; other site
479433001608	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
479433001609	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433001610	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
479433001611	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533
479433001612	homodimer interface [polypeptide binding]; other site
479433001613	metal binding site [ion binding]; metal-binding site
479433001614	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
479433001615	nudix motif; other site
479433001616	B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034
479433001617	Rhomboid family; Region: Rhomboid; pfam01694
479433001618	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
479433001619	trimer interface [polypeptide binding]; other site
479433001620	CoA binding site [chemical binding]; other site
479433001621	active site
479433001622	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
479433001623	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
479433001624	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433001625	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433001626	dimerization interface [polypeptide binding]; other site
479433001627	ligand binding site [chemical binding]; other site
479433001628	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167
479433001629	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
479433001630	putative ligand binding site [chemical binding]; other site
479433001631	putative NAD binding site [chemical binding]; other site
479433001632	catalytic site [active]
479433001633	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
479433001634	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433001635	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433001636	dimer interface [polypeptide binding]; other site
479433001637	conserved gate region; other site
479433001638	putative PBP binding loops; other site
479433001639	ABC-ATPase subunit interface; other site
479433001640	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433001641	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433001642	dimer interface [polypeptide binding]; other site
479433001643	conserved gate region; other site
479433001644	putative PBP binding loops; other site
479433001645	ABC-ATPase subunit interface; other site
479433001646	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
479433001647	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
479433001648	oligomeric interface; other site
479433001649	putative active site [active]
479433001650	homodimer interface [polypeptide binding]; other site
479433001651	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
479433001652	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
479433001653	nudix motif; other site
479433001654	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
479433001655	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433001656	Beta-lactamase; Region: Beta-lactamase; pfam00144
479433001657	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
479433001658	Putative sensor; Region: Sensor; pfam13796
479433001659	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433001660	Histidine kinase; Region: HisKA_3; pfam07730
479433001661	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433001662	ATP binding site [chemical binding]; other site
479433001663	Mg2+ binding site [ion binding]; other site
479433001664	G-X-G motif; other site
479433001665	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433001666	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433001667	active site
479433001668	phosphorylation site [posttranslational modification]
479433001669	intermolecular recognition site; other site
479433001670	dimerization interface [polypeptide binding]; other site
479433001671	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433001672	DNA binding residues [nucleotide binding]
479433001673	dimerization interface [polypeptide binding]; other site
479433001674	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433001675	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433001676	active site
479433001677	phosphorylation site [posttranslational modification]
479433001678	intermolecular recognition site; other site
479433001679	dimerization interface [polypeptide binding]; other site
479433001680	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433001681	DNA binding residues [nucleotide binding]
479433001682	dimerization interface [polypeptide binding]; other site
479433001683	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433001684	Histidine kinase; Region: HisKA_3; pfam07730
479433001685	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433001686	ATP binding site [chemical binding]; other site
479433001687	Mg2+ binding site [ion binding]; other site
479433001688	G-X-G motif; other site
479433001689	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
479433001690	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
479433001691	dimer interface [polypeptide binding]; other site
479433001692	active site
479433001693	Domain of unknown function (DUF4287); Region: DUF4287; pfam14117
479433001694	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
479433001695	active site
479433001696	catalytic triad [active]
479433001697	oxyanion hole [active]
479433001698	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
479433001699	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
479433001700	dimer interface [polypeptide binding]; other site
479433001701	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433001702	catalytic residue [active]
479433001703	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
479433001704	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
479433001705	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
479433001706	Proline dehydrogenase; Region: Pro_dh; cl03282
479433001707	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
479433001708	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
479433001709	Glutamate binding site [chemical binding]; other site
479433001710	NAD binding site [chemical binding]; other site
479433001711	catalytic residues [active]
479433001712	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
479433001713	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
479433001714	active site
479433001715	catalytic residues [active]
479433001716	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
479433001717	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
479433001718	SCP-2 sterol transfer family; Region: SCP2; cl01225
479433001719	Domain of unknown function (DUF1990); Region: DUF1990; cl01969
479433001720	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
479433001721	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
479433001722	Protein of unknown function DUF72; Region: DUF72; pfam01904
479433001723	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
479433001724	cystathionine gamma-synthase; Provisional; Region: PRK07811
479433001725	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
479433001726	homodimer interface [polypeptide binding]; other site
479433001727	substrate-cofactor binding pocket; other site
479433001728	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433001729	catalytic residue [active]
479433001730	EamA-like transporter family; Region: EamA; pfam00892
479433001731	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
479433001732	EamA-like transporter family; Region: EamA; pfam00892
479433001733	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433001734	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
479433001735	nucleotide binding site [chemical binding]; other site
479433001736	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433001737	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433001738	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433001739	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433001740	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433001741	putative DNA binding site [nucleotide binding]; other site
479433001742	putative Zn2+ binding site [ion binding]; other site
479433001743	threonine dehydratase; Provisional; Region: PRK08198
479433001744	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
479433001745	tetramer interface [polypeptide binding]; other site
479433001746	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433001747	catalytic residue [active]
479433001748	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
479433001749	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433001750	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
479433001751	Walker A/P-loop; other site
479433001752	ATP binding site [chemical binding]; other site
479433001753	Q-loop/lid; other site
479433001754	ABC transporter signature motif; other site
479433001755	Walker B; other site
479433001756	D-loop; other site
479433001757	H-loop/switch region; other site
479433001758	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
479433001759	ABC-2 type transporter; Region: ABC2_membrane; cl17235
479433001760	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433001761	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433001762	active site
479433001763	ATP binding site [chemical binding]; other site
479433001764	substrate binding site [chemical binding]; other site
479433001765	activation loop (A-loop); other site
479433001766	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
479433001767	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
479433001768	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
479433001769	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
479433001770	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
479433001771	hypothetical protein; Provisional; Region: PRK09256
479433001772	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734
479433001773	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433001774	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
479433001775	Walker A/P-loop; other site
479433001776	ATP binding site [chemical binding]; other site
479433001777	Q-loop/lid; other site
479433001778	ABC transporter signature motif; other site
479433001779	Walker B; other site
479433001780	D-loop; other site
479433001781	H-loop/switch region; other site
479433001782	Predicted transcriptional regulators [Transcription]; Region: COG1725
479433001783	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433001784	DNA-binding site [nucleotide binding]; DNA binding site
479433001785	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433001786	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433001787	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433001788	DNA binding residues [nucleotide binding]
479433001789	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
479433001790	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
479433001791	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
479433001792	FtsX-like permease family; Region: FtsX; pfam02687
479433001793	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
479433001794	FtsX-like permease family; Region: FtsX; pfam02687
479433001795	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
479433001796	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
479433001797	Walker A/P-loop; other site
479433001798	ATP binding site [chemical binding]; other site
479433001799	Q-loop/lid; other site
479433001800	ABC transporter signature motif; other site
479433001801	Walker B; other site
479433001802	D-loop; other site
479433001803	H-loop/switch region; other site
479433001804	Histidine kinase; Region: HisKA_3; pfam07730
479433001805	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433001806	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433001807	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433001808	active site
479433001809	phosphorylation site [posttranslational modification]
479433001810	intermolecular recognition site; other site
479433001811	dimerization interface [polypeptide binding]; other site
479433001812	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433001813	DNA binding residues [nucleotide binding]
479433001814	dimerization interface [polypeptide binding]; other site
479433001815	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
479433001816	Clp amino terminal domain; Region: Clp_N; pfam02861
479433001817	Clp amino terminal domain; Region: Clp_N; pfam02861
479433001818	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433001819	Walker A motif; other site
479433001820	ATP binding site [chemical binding]; other site
479433001821	Walker B motif; other site
479433001822	arginine finger; other site
479433001823	UvrB/uvrC motif; Region: UVR; pfam02151
479433001824	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433001825	Walker A motif; other site
479433001826	ATP binding site [chemical binding]; other site
479433001827	Walker B motif; other site
479433001828	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
479433001829	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433001830	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
479433001831	HD domain; Region: HD_4; pfam13328
479433001832	Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669
479433001833	oligomer interface [polypeptide binding]; other site
479433001834	Transmembrane secretion effector; Region: MFS_3; pfam05977
479433001835	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433001836	Histidine kinase; Region: HisKA_3; pfam07730
479433001837	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433001838	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433001839	active site
479433001840	phosphorylation site [posttranslational modification]
479433001841	intermolecular recognition site; other site
479433001842	dimerization interface [polypeptide binding]; other site
479433001843	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433001844	DNA binding residues [nucleotide binding]
479433001845	dimerization interface [polypeptide binding]; other site
479433001846	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
479433001847	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
479433001848	Walker A/P-loop; other site
479433001849	ATP binding site [chemical binding]; other site
479433001850	Q-loop/lid; other site
479433001851	ABC transporter signature motif; other site
479433001852	Walker B; other site
479433001853	D-loop; other site
479433001854	H-loop/switch region; other site
479433001855	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
479433001856	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
479433001857	FtsX-like permease family; Region: FtsX; pfam02687
479433001858	FtsX-like permease family; Region: FtsX; pfam02687
479433001859	HSP90 family protein; Provisional; Region: PRK14083
479433001860	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433001861	ATP binding site [chemical binding]; other site
479433001862	Mg2+ binding site [ion binding]; other site
479433001863	G-X-G motif; other site
479433001864	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
479433001865	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
479433001866	ATP binding site [chemical binding]; other site
479433001867	putative Mg++ binding site [ion binding]; other site
479433001868	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
479433001869	nucleotide binding region [chemical binding]; other site
479433001870	ATP-binding site [chemical binding]; other site
479433001871	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
479433001872	HRDC domain; Region: HRDC; pfam00570
479433001873	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433001874	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433001875	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
479433001876	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
479433001877	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433001878	MarR family; Region: MarR; pfam01047
479433001879	RDD family; Region: RDD; pfam06271
479433001880	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
479433001881	AAA domain; Region: AAA_14; pfam13173
479433001882	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
479433001883	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
479433001884	catalytic residues [active]
479433001885	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433001886	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433001887	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433001888	DNA binding residues [nucleotide binding]
479433001889	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
479433001890	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433001891	NAD(P) binding site [chemical binding]; other site
479433001892	active site
479433001893	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
479433001894	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
479433001895	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
479433001896	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
479433001897	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433001898	DNA-binding site [nucleotide binding]; DNA binding site
479433001899	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
479433001900	cyanate transporter; Region: CynX; TIGR00896
479433001901	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433001902	putative substrate translocation pore; other site
479433001903	fumarate hydratase; Provisional; Region: PRK15389
479433001904	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
479433001905	Fumarase C-terminus; Region: Fumerase_C; pfam05683
479433001906	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
479433001907	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
479433001908	nudix motif; other site
479433001909	Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564
479433001910	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
479433001911	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
479433001912	active site
479433001913	intersubunit interface [polypeptide binding]; other site
479433001914	catalytic residue [active]
479433001915	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
479433001916	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
479433001917	active site
479433001918	putative substrate binding pocket [chemical binding]; other site
479433001919	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
479433001920	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
479433001921	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
479433001922	dimer interface [polypeptide binding]; other site
479433001923	active site
479433001924	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
479433001925	substrate binding site [chemical binding]; other site
479433001926	catalytic residue [active]
479433001927	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
479433001928	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
479433001929	substrate binding site [chemical binding]; other site
479433001930	ATP binding site [chemical binding]; other site
479433001931	Transcriptional regulator [Transcription]; Region: IclR; COG1414
479433001932	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
479433001933	Bacterial transcriptional regulator; Region: IclR; pfam01614
479433001934	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
479433001935	homotrimer interaction site [polypeptide binding]; other site
479433001936	putative active site [active]
479433001937	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433001938	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433001939	active site
479433001940	ATP binding site [chemical binding]; other site
479433001941	substrate binding site [chemical binding]; other site
479433001942	activation loop (A-loop); other site
479433001943	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433001944	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433001945	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
479433001946	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
479433001947	N-acetyl-D-glucosamine binding site [chemical binding]; other site
479433001948	catalytic residue [active]
479433001949	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
479433001950	N-acetyl-D-glucosamine binding site [chemical binding]; other site
479433001951	catalytic residue [active]
479433001952	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
479433001953	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
479433001954	putative active site [active]
479433001955	PhoH-like protein; Region: PhoH; pfam02562
479433001956	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
479433001957	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
479433001958	catalytic residue [active]
479433001959	putative FPP diphosphate  binding site; other site
479433001960	putative FPP binding hydrophobic cleft; other site
479433001961	dimer interface [polypeptide binding]; other site
479433001962	putative IPP diphosphate binding site; other site
479433001963	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
479433001964	active site
479433001965	substrate-binding site [chemical binding]; other site
479433001966	metal-binding site [ion binding]
479433001967	GTP binding site [chemical binding]; other site
479433001968	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
479433001969	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433001970	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433001971	non-specific DNA binding site [nucleotide binding]; other site
479433001972	salt bridge; other site
479433001973	sequence-specific DNA binding site [nucleotide binding]; other site
479433001974	Protein of unknown function DUF47; Region: PhoU_div; pfam01865
479433001975	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
479433001976	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
479433001977	aromatic arch; other site
479433001978	DCoH dimer interaction site [polypeptide binding]; other site
479433001979	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
479433001980	DCoH tetramer interaction site [polypeptide binding]; other site
479433001981	substrate binding site [chemical binding]; other site
479433001982	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
479433001983	active site
479433001984	8-oxo-dGMP binding site [chemical binding]; other site
479433001985	nudix motif; other site
479433001986	metal binding site [ion binding]; metal-binding site
479433001987	PAS fold; Region: PAS; pfam00989
479433001988	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
479433001989	putative active site [active]
479433001990	heme pocket [chemical binding]; other site
479433001991	PAS fold; Region: PAS_4; pfam08448
479433001992	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
479433001993	putative active site [active]
479433001994	heme pocket [chemical binding]; other site
479433001995	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
479433001996	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
479433001997	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
479433001998	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433001999	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
479433002000	N-acetyltransferase; Region: Acetyltransf_2; pfam00797
479433002001	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386
479433002002	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
479433002003	catalytic loop [active]
479433002004	iron binding site [ion binding]; other site
479433002005	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803
479433002006	L-aspartate oxidase; Provisional; Region: PRK06175
479433002007	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
479433002008	Protein kinase domain; Region: Pkinase; pfam00069
479433002009	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433002010	active site
479433002011	ATP binding site [chemical binding]; other site
479433002012	substrate binding site [chemical binding]; other site
479433002013	activation loop (A-loop); other site
479433002014	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
479433002015	PQQ-like domain; Region: PQQ_2; pfam13360
479433002016	Trp docking motif [polypeptide binding]; other site
479433002017	active site
479433002018	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
479433002019	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
479433002020	G1 box; other site
479433002021	putative GEF interaction site [polypeptide binding]; other site
479433002022	GTP/Mg2+ binding site [chemical binding]; other site
479433002023	Switch I region; other site
479433002024	G2 box; other site
479433002025	G3 box; other site
479433002026	Switch II region; other site
479433002027	G4 box; other site
479433002028	G5 box; other site
479433002029	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
479433002030	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
479433002031	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
479433002032	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433002033	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433002034	active site
479433002035	ATP binding site [chemical binding]; other site
479433002036	substrate binding site [chemical binding]; other site
479433002037	activation loop (A-loop); other site
479433002038	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
479433002039	FOG: WD40 repeat [General function prediction only]; Region: COG2319
479433002040	structural tetrad; other site
479433002041	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
479433002042	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
479433002043	N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445
479433002044	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
479433002045	VanW like protein; Region: VanW; pfam04294
479433002046	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
479433002047	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
479433002048	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433002049	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
479433002050	Walker A/P-loop; other site
479433002051	ATP binding site [chemical binding]; other site
479433002052	Q-loop/lid; other site
479433002053	ABC transporter signature motif; other site
479433002054	Walker B; other site
479433002055	D-loop; other site
479433002056	H-loop/switch region; other site
479433002057	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
479433002058	ABC-2 type transporter; Region: ABC2_membrane; cl17235
479433002059	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433002060	Histidine kinase; Region: HisKA_3; pfam07730
479433002061	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433002062	ATP binding site [chemical binding]; other site
479433002063	Mg2+ binding site [ion binding]; other site
479433002064	G-X-G motif; other site
479433002065	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433002066	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433002067	active site
479433002068	phosphorylation site [posttranslational modification]
479433002069	intermolecular recognition site; other site
479433002070	dimerization interface [polypeptide binding]; other site
479433002071	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433002072	DNA binding residues [nucleotide binding]
479433002073	dimerization interface [polypeptide binding]; other site
479433002074	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433002075	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433002076	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433002077	DNA binding residues [nucleotide binding]
479433002078	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433002079	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433002080	putative substrate translocation pore; other site
479433002081	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433002082	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433002083	Subtilisin inhibitor-like; Region: SSI; cl11594
479433002084	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
479433002085	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
479433002086	catalytic loop [active]
479433002087	iron binding site [ion binding]; other site
479433002088	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
479433002089	L-aspartate oxidase; Provisional; Region: PRK06175
479433002090	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
479433002091	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
479433002092	putative Iron-sulfur protein interface [polypeptide binding]; other site
479433002093	putative proximal heme binding site [chemical binding]; other site
479433002094	putative SdhC-like subunit interface [polypeptide binding]; other site
479433002095	putative distal heme binding site [chemical binding]; other site
479433002096	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
479433002097	putative Iron-sulfur protein interface [polypeptide binding]; other site
479433002098	putative proximal heme binding site [chemical binding]; other site
479433002099	putative SdhD-like interface [polypeptide binding]; other site
479433002100	putative distal heme binding site [chemical binding]; other site
479433002101	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433002102	Cytochrome P450; Region: p450; cl12078
479433002103	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
479433002104	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
479433002105	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433002106	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433002107	DNA binding residues [nucleotide binding]
479433002108	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
479433002109	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
479433002110	metal binding site [ion binding]; metal-binding site
479433002111	putative dimer interface [polypeptide binding]; other site
479433002112	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
479433002113	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
479433002114	ligand binding site [chemical binding]; other site
479433002115	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
479433002116	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433002117	Walker A/P-loop; other site
479433002118	ATP binding site [chemical binding]; other site
479433002119	Q-loop/lid; other site
479433002120	ABC transporter signature motif; other site
479433002121	Walker B; other site
479433002122	D-loop; other site
479433002123	H-loop/switch region; other site
479433002124	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
479433002125	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
479433002126	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
479433002127	TM-ABC transporter signature motif; other site
479433002128	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
479433002129	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
479433002130	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
479433002131	TM-ABC transporter signature motif; other site
479433002132	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
479433002133	active site
479433002134	catalytic motif [active]
479433002135	Zn binding site [ion binding]; other site
479433002136	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
479433002137	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
479433002138	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
479433002139	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
479433002140	adenosine deaminase; Provisional; Region: PRK09358
479433002141	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
479433002142	active site
479433002143	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
479433002144	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433002145	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433002146	dimer interface [polypeptide binding]; other site
479433002147	phosphorylation site [posttranslational modification]
479433002148	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433002149	ATP binding site [chemical binding]; other site
479433002150	Mg2+ binding site [ion binding]; other site
479433002151	G-X-G motif; other site
479433002152	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433002153	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433002154	active site
479433002155	phosphorylation site [posttranslational modification]
479433002156	intermolecular recognition site; other site
479433002157	dimerization interface [polypeptide binding]; other site
479433002158	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433002159	DNA binding site [nucleotide binding]
479433002160	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433002161	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433002162	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433002163	DNA binding residues [nucleotide binding]
479433002164	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
479433002165	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
479433002166	NAD(P) binding site [chemical binding]; other site
479433002167	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
479433002168	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
479433002169	NAD(P) binding site [chemical binding]; other site
479433002170	catalytic residues [active]
479433002171	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
479433002172	intersubunit interface [polypeptide binding]; other site
479433002173	active site
479433002174	catalytic residue [active]
479433002175	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433002176	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
479433002177	hypothetical protein; Provisional; Region: PRK07236
479433002178	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
479433002179	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
479433002180	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
479433002181	active site
479433002182	substrate binding site [chemical binding]; other site
479433002183	metal binding site [ion binding]; metal-binding site
479433002184	purine nucleoside phosphorylase; Provisional; Region: PRK08202
479433002185	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433002186	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433002187	putative substrate translocation pore; other site
479433002188	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
479433002189	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
479433002190	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
479433002191	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
479433002192	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
479433002193	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
479433002194	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
479433002195	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
479433002196	carboxyltransferase (CT) interaction site; other site
479433002197	biotinylation site [posttranslational modification]; other site
479433002198	Rhomboid family; Region: Rhomboid; pfam01694
479433002199	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
479433002200	Isochorismatase family; Region: Isochorismatase; pfam00857
479433002201	catalytic triad [active]
479433002202	conserved cis-peptide bond; other site
479433002203	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433002204	Cytochrome P450; Region: p450; cl12078
479433002205	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
479433002206	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
479433002207	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
479433002208	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
479433002209	metal binding site [ion binding]; metal-binding site
479433002210	active site
479433002211	I-site; other site
479433002212	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
479433002213	active site
479433002214	catalytic residues [active]
479433002215	metal binding site [ion binding]; metal-binding site
479433002216	cyclase homology domain; Region: CHD; cd07302
479433002217	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
479433002218	nucleotidyl binding site; other site
479433002219	metal binding site [ion binding]; metal-binding site
479433002220	dimer interface [polypeptide binding]; other site
479433002221	Bacterial PH domain; Region: DUF304; pfam03703
479433002222	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
479433002223	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
479433002224	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
479433002225	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
479433002226	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
479433002227	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
479433002228	Maf-like protein; Region: Maf; pfam02545
479433002229	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
479433002230	active site
479433002231	dimer interface [polypeptide binding]; other site
479433002232	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
479433002233	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
479433002234	NodB motif; other site
479433002235	active site
479433002236	catalytic site [active]
479433002237	metal binding site [ion binding]; metal-binding site
479433002238	Uncharacterized conserved protein [Function unknown]; Region: COG3391
479433002239	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
479433002240	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
479433002241	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
479433002242	oligomeric interface; other site
479433002243	putative active site [active]
479433002244	homodimer interface [polypeptide binding]; other site
479433002245	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
479433002246	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
479433002247	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
479433002248	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433002249	Walker A/P-loop; other site
479433002250	ATP binding site [chemical binding]; other site
479433002251	Q-loop/lid; other site
479433002252	ABC transporter signature motif; other site
479433002253	Walker B; other site
479433002254	D-loop; other site
479433002255	H-loop/switch region; other site
479433002256	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
479433002257	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
479433002258	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433002259	Walker A/P-loop; other site
479433002260	ATP binding site [chemical binding]; other site
479433002261	Q-loop/lid; other site
479433002262	ABC transporter signature motif; other site
479433002263	Walker B; other site
479433002264	D-loop; other site
479433002265	H-loop/switch region; other site
479433002266	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
479433002267	N-acetyl-D-glucosamine binding site [chemical binding]; other site
479433002268	catalytic residue [active]
479433002269	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
479433002270	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
479433002271	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
479433002272	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
479433002273	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433002274	putative substrate translocation pore; other site
479433002275	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433002276	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433002277	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433002278	active site
479433002279	phosphorylation site [posttranslational modification]
479433002280	intermolecular recognition site; other site
479433002281	dimerization interface [polypeptide binding]; other site
479433002282	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433002283	DNA binding site [nucleotide binding]
479433002284	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433002285	HAMP domain; Region: HAMP; pfam00672
479433002286	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433002287	dimer interface [polypeptide binding]; other site
479433002288	phosphorylation site [posttranslational modification]
479433002289	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433002290	ATP binding site [chemical binding]; other site
479433002291	Mg2+ binding site [ion binding]; other site
479433002292	G-X-G motif; other site
479433002293	Predicted membrane protein [Function unknown]; Region: COG2246
479433002294	GtrA-like protein; Region: GtrA; pfam04138
479433002295	Predicted membrane protein [Function unknown]; Region: COG2246
479433002296	GtrA-like protein; Region: GtrA; pfam04138
479433002297	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
479433002298	LabA_like proteins; Region: LabA_like/DUF88; cl10034
479433002299	putative metal binding site [ion binding]; other site
479433002300	ATP-grasp domain; Region: ATP-grasp; pfam02222
479433002301	AIR carboxylase; Region: AIRC; pfam00731
479433002302	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433002303	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433002304	active site
479433002305	ATP binding site [chemical binding]; other site
479433002306	substrate binding site [chemical binding]; other site
479433002307	activation loop (A-loop); other site
479433002308	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
479433002309	NADH dehydrogenase subunit B; Validated; Region: PRK06411
479433002310	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
479433002311	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
479433002312	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
479433002313	4Fe-4S binding domain; Region: Fer4; pfam00037
479433002314	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
479433002315	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
479433002316	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
479433002317	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
479433002318	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
479433002319	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
479433002320	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
479433002321	heat shock protein HtpX; Provisional; Region: PRK03072
479433002322	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
479433002323	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
479433002324	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
479433002325	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
479433002326	active site
479433002327	catalytic triad [active]
479433002328	calcium binding site [ion binding]; other site
479433002329	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
479433002330	peptidase domain interface [polypeptide binding]; other site
479433002331	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
479433002332	active site
479433002333	catalytic triad [active]
479433002334	calcium binding site [ion binding]; other site
479433002335	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
479433002336	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
479433002337	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433002338	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
479433002339	Fructosamine kinase; Region: Fructosamin_kin; cl17579
479433002340	Phosphotransferase enzyme family; Region: APH; pfam01636
479433002341	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
479433002342	6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254
479433002343	putative NAD(P) binding site [chemical binding]; other site
479433002344	catalytic Zn binding site [ion binding]; other site
479433002345	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
479433002346	Uncharacterized conserved protein [Function unknown]; Region: COG1434
479433002347	putative active site [active]
479433002348	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
479433002349	active site
479433002350	catalytic site [active]
479433002351	substrate binding site [chemical binding]; other site
479433002352	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
479433002353	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
479433002354	catalytic residues [active]
479433002355	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433002356	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433002357	WHG domain; Region: WHG; pfam13305
479433002358	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
479433002359	Protein of unknown function (DUF1271); Region: DUF1271; pfam06902
479433002360	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
479433002361	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
479433002362	apolar tunnel; other site
479433002363	heme binding site [chemical binding]; other site
479433002364	dimerization interface [polypeptide binding]; other site
479433002365	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433002366	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433002367	Condensation domain; Region: Condensation; pfam00668
479433002368	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
479433002369	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433002370	Walker A motif; other site
479433002371	ATP binding site [chemical binding]; other site
479433002372	Walker B motif; other site
479433002373	arginine finger; other site
479433002374	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
479433002375	RibD C-terminal domain; Region: RibD_C; cl17279
479433002376	Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844
479433002377	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
479433002378	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
479433002379	TAP-like protein; Region: Abhydrolase_4; pfam08386
479433002380	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
479433002381	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
479433002382	active site
479433002383	catalytic residues [active]
479433002384	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433002385	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433002386	active site
479433002387	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
479433002388	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
479433002389	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433002390	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
479433002391	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
479433002392	Domain of unknown function (DUF4380); Region: DUF4380; pfam14315
479433002393	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433002394	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433002395	dimer interface [polypeptide binding]; other site
479433002396	conserved gate region; other site
479433002397	putative PBP binding loops; other site
479433002398	ABC-ATPase subunit interface; other site
479433002399	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433002400	dimer interface [polypeptide binding]; other site
479433002401	conserved gate region; other site
479433002402	putative PBP binding loops; other site
479433002403	ABC-ATPase subunit interface; other site
479433002404	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433002405	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433002406	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433002407	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
479433002408	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
479433002409	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
479433002410	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
479433002411	dimer interface [polypeptide binding]; other site
479433002412	active site
479433002413	ADP-ribose binding site [chemical binding]; other site
479433002414	nudix motif; other site
479433002415	metal binding site [ion binding]; metal-binding site
479433002416	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
479433002417	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
479433002418	active site
479433002419	catalytic site [active]
479433002420	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
479433002421	active site
479433002422	catalytic site [active]
479433002423	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
479433002424	FAD binding domain; Region: FAD_binding_4; pfam01565
479433002425	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
479433002426	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
479433002427	DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188
479433002428	Ligand binding site; other site
479433002429	Ligand binding site; other site
479433002430	Ligand binding site; other site
479433002431	Putative Catalytic site; other site
479433002432	DXD motif; other site
479433002433	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433002434	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433002435	dimerization interface [polypeptide binding]; other site
479433002436	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433002437	dimer interface [polypeptide binding]; other site
479433002438	phosphorylation site [posttranslational modification]
479433002439	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433002440	ATP binding site [chemical binding]; other site
479433002441	Mg2+ binding site [ion binding]; other site
479433002442	G-X-G motif; other site
479433002443	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433002444	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433002445	active site
479433002446	phosphorylation site [posttranslational modification]
479433002447	intermolecular recognition site; other site
479433002448	dimerization interface [polypeptide binding]; other site
479433002449	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433002450	DNA binding site [nucleotide binding]
479433002451	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433002452	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433002453	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433002454	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433002455	putative substrate translocation pore; other site
479433002456	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433002457	aspartate aminotransferase; Provisional; Region: PRK05764
479433002458	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
479433002459	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433002460	homodimer interface [polypeptide binding]; other site
479433002461	catalytic residue [active]
479433002462	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
479433002463	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
479433002464	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
479433002465	putative homodimer interface [polypeptide binding]; other site
479433002466	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
479433002467	heterodimer interface [polypeptide binding]; other site
479433002468	homodimer interface [polypeptide binding]; other site
479433002469	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
479433002470	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
479433002471	23S rRNA interface [nucleotide binding]; other site
479433002472	L7/L12 interface [polypeptide binding]; other site
479433002473	putative thiostrepton binding site; other site
479433002474	L25 interface [polypeptide binding]; other site
479433002475	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
479433002476	mRNA/rRNA interface [nucleotide binding]; other site
479433002477	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
479433002478	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
479433002479	DNA binding residues [nucleotide binding]
479433002480	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
479433002481	23S rRNA interface [nucleotide binding]; other site
479433002482	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
479433002483	core dimer interface [polypeptide binding]; other site
479433002484	peripheral dimer interface [polypeptide binding]; other site
479433002485	L10 interface [polypeptide binding]; other site
479433002486	L11 interface [polypeptide binding]; other site
479433002487	putative EF-Tu interaction site [polypeptide binding]; other site
479433002488	putative EF-G interaction site [polypeptide binding]; other site
479433002489	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
479433002490	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
479433002491	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
479433002492	RPB10 interaction site [polypeptide binding]; other site
479433002493	RPB1 interaction site [polypeptide binding]; other site
479433002494	RPB11 interaction site [polypeptide binding]; other site
479433002495	RPB3 interaction site [polypeptide binding]; other site
479433002496	RPB12 interaction site [polypeptide binding]; other site
479433002497	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
479433002498	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
479433002499	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
479433002500	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
479433002501	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
479433002502	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
479433002503	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
479433002504	G-loop; other site
479433002505	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
479433002506	DNA binding site [nucleotide binding]
479433002507	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
479433002508	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
479433002509	S17 interaction site [polypeptide binding]; other site
479433002510	S8 interaction site; other site
479433002511	16S rRNA interaction site [nucleotide binding]; other site
479433002512	streptomycin interaction site [chemical binding]; other site
479433002513	23S rRNA interaction site [nucleotide binding]; other site
479433002514	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
479433002515	30S ribosomal protein S7; Validated; Region: PRK05302
479433002516	elongation factor G; Reviewed; Region: PRK00007
479433002517	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
479433002518	G1 box; other site
479433002519	putative GEF interaction site [polypeptide binding]; other site
479433002520	GTP/Mg2+ binding site [chemical binding]; other site
479433002521	Switch I region; other site
479433002522	G2 box; other site
479433002523	G3 box; other site
479433002524	Switch II region; other site
479433002525	G4 box; other site
479433002526	G5 box; other site
479433002527	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
479433002528	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
479433002529	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
479433002530	elongation factor Tu; Reviewed; Region: PRK00049
479433002531	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
479433002532	G1 box; other site
479433002533	GEF interaction site [polypeptide binding]; other site
479433002534	GTP/Mg2+ binding site [chemical binding]; other site
479433002535	Switch I region; other site
479433002536	G2 box; other site
479433002537	G3 box; other site
479433002538	Switch II region; other site
479433002539	G4 box; other site
479433002540	G5 box; other site
479433002541	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
479433002542	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
479433002543	Antibiotic Binding Site [chemical binding]; other site
479433002544	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
479433002545	oligomeric interface; other site
479433002546	homodimer interface [polypeptide binding]; other site
479433002547	putative active site [active]
479433002548	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
479433002549	hypothetical protein; Provisional; Region: PRK07236
479433002550	hypothetical protein; Provisional; Region: PRK07588
479433002551	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
479433002552	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
479433002553	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
479433002554	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
479433002555	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
479433002556	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
479433002557	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
479433002558	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
479433002559	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
479433002560	putative translocon binding site; other site
479433002561	protein-rRNA interface [nucleotide binding]; other site
479433002562	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
479433002563	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
479433002564	G-X-X-G motif; other site
479433002565	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
479433002566	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
479433002567	23S rRNA interface [nucleotide binding]; other site
479433002568	5S rRNA interface [nucleotide binding]; other site
479433002569	putative antibiotic binding site [chemical binding]; other site
479433002570	L25 interface [polypeptide binding]; other site
479433002571	L27 interface [polypeptide binding]; other site
479433002572	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
479433002573	putative translocon interaction site; other site
479433002574	23S rRNA interface [nucleotide binding]; other site
479433002575	signal recognition particle (SRP54) interaction site; other site
479433002576	L23 interface [polypeptide binding]; other site
479433002577	trigger factor interaction site; other site
479433002578	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
479433002579	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
479433002580	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
479433002581	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
479433002582	RNA binding site [nucleotide binding]; other site
479433002583	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
479433002584	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
479433002585	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
479433002586	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
479433002587	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
479433002588	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
479433002589	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
479433002590	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
479433002591	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
479433002592	5S rRNA interface [nucleotide binding]; other site
479433002593	L27 interface [polypeptide binding]; other site
479433002594	23S rRNA interface [nucleotide binding]; other site
479433002595	L5 interface [polypeptide binding]; other site
479433002596	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
479433002597	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
479433002598	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
479433002599	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
479433002600	23S rRNA binding site [nucleotide binding]; other site
479433002601	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
479433002602	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
479433002603	SecY translocase; Region: SecY; pfam00344
479433002604	adenylate kinase; Reviewed; Region: adk; PRK00279
479433002605	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
479433002606	AMP-binding site [chemical binding]; other site
479433002607	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
479433002608	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
479433002609	active site
479433002610	PknH-like extracellular domain; Region: PknH_C; pfam14032
479433002611	MMPL family; Region: MMPL; pfam03176
479433002612	MMPL family; Region: MMPL; pfam03176
479433002613	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433002614	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433002615	active site
479433002616	phosphorylation site [posttranslational modification]
479433002617	intermolecular recognition site; other site
479433002618	dimerization interface [polypeptide binding]; other site
479433002619	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433002620	DNA binding residues [nucleotide binding]
479433002621	dimerization interface [polypeptide binding]; other site
479433002622	Histidine kinase; Region: HisKA_3; pfam07730
479433002623	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433002624	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
479433002625	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
479433002626	rRNA binding site [nucleotide binding]; other site
479433002627	predicted 30S ribosome binding site; other site
479433002628	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
479433002629	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
479433002630	30S ribosomal protein S13; Region: bact_S13; TIGR03631
479433002631	30S ribosomal protein S11; Validated; Region: PRK05309
479433002632	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
479433002633	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
479433002634	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
479433002635	RNA binding surface [nucleotide binding]; other site
479433002636	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
479433002637	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
479433002638	alphaNTD homodimer interface [polypeptide binding]; other site
479433002639	alphaNTD - beta interaction site [polypeptide binding]; other site
479433002640	alphaNTD - beta' interaction site [polypeptide binding]; other site
479433002641	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
479433002642	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
479433002643	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
479433002644	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
479433002645	dimerization interface 3.5A [polypeptide binding]; other site
479433002646	active site
479433002647	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
479433002648	Predicted flavoprotein [General function prediction only]; Region: COG0431
479433002649	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
479433002650	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
479433002651	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
479433002652	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
479433002653	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
479433002654	23S rRNA interface [nucleotide binding]; other site
479433002655	L3 interface [polypeptide binding]; other site
479433002656	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
479433002657	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
479433002658	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
479433002659	active site
479433002660	substrate binding site [chemical binding]; other site
479433002661	metal binding site [ion binding]; metal-binding site
479433002662	diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830
479433002663	6-phosphofructokinase; Region: PLN02884
479433002664	active site
479433002665	ADP/pyrophosphate binding site [chemical binding]; other site
479433002666	dimerization interface [polypeptide binding]; other site
479433002667	allosteric effector site; other site
479433002668	fructose-1,6-bisphosphate binding site; other site
479433002669	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
479433002670	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433002671	Walker A/P-loop; other site
479433002672	ATP binding site [chemical binding]; other site
479433002673	Q-loop/lid; other site
479433002674	ABC transporter signature motif; other site
479433002675	Walker B; other site
479433002676	D-loop; other site
479433002677	H-loop/switch region; other site
479433002678	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
479433002679	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
479433002680	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433002681	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
479433002682	Walker A/P-loop; other site
479433002683	ATP binding site [chemical binding]; other site
479433002684	Q-loop/lid; other site
479433002685	ABC transporter signature motif; other site
479433002686	Walker B; other site
479433002687	D-loop; other site
479433002688	H-loop/switch region; other site
479433002689	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
479433002690	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
479433002691	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433002692	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433002693	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433002694	DNA binding residues [nucleotide binding]
479433002695	pantothenate kinase; Provisional; Region: PRK05439
479433002696	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
479433002697	ATP-binding site [chemical binding]; other site
479433002698	CoA-binding site [chemical binding]; other site
479433002699	Mg2+-binding site [ion binding]; other site
479433002700	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
479433002701	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
479433002702	glutaminase active site [active]
479433002703	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
479433002704	dimer interface [polypeptide binding]; other site
479433002705	active site
479433002706	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
479433002707	dimer interface [polypeptide binding]; other site
479433002708	active site
479433002709	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
479433002710	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
479433002711	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
479433002712	putative substrate binding site [chemical binding]; other site
479433002713	putative ATP binding site [chemical binding]; other site
479433002714	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
479433002715	alanine racemase; Reviewed; Region: alr; PRK00053
479433002716	active site
479433002717	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
479433002718	dimer interface [polypeptide binding]; other site
479433002719	substrate binding site [chemical binding]; other site
479433002720	catalytic residues [active]
479433002721	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433002722	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
479433002723	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
479433002724	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
479433002725	Ligand binding site; other site
479433002726	Putative Catalytic site; other site
479433002727	DXD motif; other site
479433002728	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
479433002729	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
479433002730	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433002731	NAD(P) binding site [chemical binding]; other site
479433002732	active site
479433002733	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
479433002734	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
479433002735	active site
479433002736	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
479433002737	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
479433002738	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
479433002739	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367
479433002740	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
479433002741	Glycoprotease family; Region: Peptidase_M22; pfam00814
479433002742	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
479433002743	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433002744	UGMP family protein; Validated; Region: PRK09604
479433002745	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
479433002746	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
479433002747	NodB motif; other site
479433002748	active site
479433002749	metal binding site [ion binding]; metal-binding site
479433002750	Dehydratase family; Region: ILVD_EDD; cl00340
479433002751	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
479433002752	oligomerisation interface [polypeptide binding]; other site
479433002753	mobile loop; other site
479433002754	roof hairpin; other site
479433002755	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
479433002756	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
479433002757	ring oligomerisation interface [polypeptide binding]; other site
479433002758	ATP/Mg binding site [chemical binding]; other site
479433002759	stacking interactions; other site
479433002760	hinge regions; other site
479433002761	Transcription factor WhiB; Region: Whib; pfam02467
479433002762	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433002763	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433002764	active site
479433002765	phosphorylation site [posttranslational modification]
479433002766	intermolecular recognition site; other site
479433002767	dimerization interface [polypeptide binding]; other site
479433002768	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433002769	DNA binding residues [nucleotide binding]
479433002770	dimerization interface [polypeptide binding]; other site
479433002771	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
479433002772	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
479433002773	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
479433002774	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
479433002775	active site
479433002776	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
479433002777	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
479433002778	phosphate binding site [ion binding]; other site
479433002779	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
479433002780	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
479433002781	catalytic residues [active]
479433002782	dimer interface [polypeptide binding]; other site
479433002783	short chain dehydrogenase; Provisional; Region: PRK06197
479433002784	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
479433002785	putative NAD(P) binding site [chemical binding]; other site
479433002786	active site
479433002787	succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407
479433002788	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
479433002789	NAD(P) binding site [chemical binding]; other site
479433002790	catalytic residues [active]
479433002791	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
479433002792	Proteins of 100 residues with WXG; Region: WXG100; cl02005
479433002793	Chorismate mutase type II; Region: CM_2; cl00693
479433002794	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
479433002795	CoenzymeA binding site [chemical binding]; other site
479433002796	subunit interaction site [polypeptide binding]; other site
479433002797	PHB binding site; other site
479433002798	Short C-terminal domain; Region: SHOCT; pfam09851
479433002799	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
479433002800	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
479433002801	Active site serine [active]
479433002802	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
479433002803	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
479433002804	FtsX-like permease family; Region: FtsX; pfam02687
479433002805	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
479433002806	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
479433002807	Walker A/P-loop; other site
479433002808	ATP binding site [chemical binding]; other site
479433002809	Q-loop/lid; other site
479433002810	ABC transporter signature motif; other site
479433002811	Walker B; other site
479433002812	D-loop; other site
479433002813	H-loop/switch region; other site
479433002814	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
479433002815	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433002816	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433002817	active site
479433002818	phosphorylation site [posttranslational modification]
479433002819	intermolecular recognition site; other site
479433002820	dimerization interface [polypeptide binding]; other site
479433002821	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433002822	DNA binding site [nucleotide binding]
479433002823	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433002824	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433002825	dimer interface [polypeptide binding]; other site
479433002826	phosphorylation site [posttranslational modification]
479433002827	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433002828	ATP binding site [chemical binding]; other site
479433002829	Mg2+ binding site [ion binding]; other site
479433002830	G-X-G motif; other site
479433002831	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
479433002832	active site
479433002833	catalytic triad [active]
479433002834	oxyanion hole [active]
479433002835	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
479433002836	Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094
479433002837	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433002838	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433002839	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
479433002840	ATP-NAD kinase; Region: NAD_kinase; pfam01513
479433002841	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
479433002842	FAD binding site [chemical binding]; other site
479433002843	Predicted transcriptional regulators [Transcription]; Region: COG1733
479433002844	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
479433002845	short chain dehydrogenase; Validated; Region: PRK08264
479433002846	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433002847	NAD(P) binding site [chemical binding]; other site
479433002848	active site
479433002849	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433002850	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433002851	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433002852	DNA binding residues [nucleotide binding]
479433002853	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433002854	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
479433002855	putative NAD(P) binding site [chemical binding]; other site
479433002856	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433002857	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
479433002858	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
479433002859	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433002860	sugar binding site [chemical binding]; other site
479433002861	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
479433002862	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
479433002863	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433002864	sugar binding site [chemical binding]; other site
479433002865	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433002866	sugar binding site [chemical binding]; other site
479433002867	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
479433002868	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
479433002869	SecY translocase; Region: SecY; pfam00344
479433002870	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433002871	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433002872	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433002873	DNA binding residues [nucleotide binding]
479433002874	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433002875	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433002876	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433002877	DNA binding residues [nucleotide binding]
479433002878	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
479433002879	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433002880	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433002881	ATP binding site [chemical binding]; other site
479433002882	Mg2+ binding site [ion binding]; other site
479433002883	G-X-G motif; other site
479433002884	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
479433002885	Protein of unknown function (DUF742); Region: DUF742; pfam05331
479433002886	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
479433002887	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
479433002888	G1 box; other site
479433002889	GTP/Mg2+ binding site [chemical binding]; other site
479433002890	G2 box; other site
479433002891	Switch I region; other site
479433002892	G3 box; other site
479433002893	Switch II region; other site
479433002894	G4 box; other site
479433002895	G5 box; other site
479433002896	GAF domain; Region: GAF; pfam01590
479433002897	GAF domain; Region: GAF_2; pfam13185
479433002898	TAP-like protein; Region: Abhydrolase_4; pfam08386
479433002899	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433002900	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433002901	DNA binding residues [nucleotide binding]
479433002902	dimerization interface [polypeptide binding]; other site
479433002903	RibD C-terminal domain; Region: RibD_C; cl17279
479433002904	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433002905	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433002906	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
479433002907	putative active site pocket [active]
479433002908	dimerization interface [polypeptide binding]; other site
479433002909	putative catalytic residue [active]
479433002910	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
479433002911	active site
479433002912	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
479433002913	phosphate binding site [ion binding]; other site
479433002914	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
479433002915	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433002916	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
479433002917	dimerization interface [polypeptide binding]; other site
479433002918	substrate binding pocket [chemical binding]; other site
479433002919	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
479433002920	Domain of unknown function (DUF4234); Region: DUF4234; pfam14018
479433002921	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
479433002922	AAA domain; Region: AAA_18; pfam13238
479433002923	active site
479433002924	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
479433002925	CGNR zinc finger; Region: zf-CGNR; pfam11706
479433002926	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433002927	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
479433002928	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433002929	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433002930	short chain dehydrogenase; Provisional; Region: PRK07041
479433002931	NAD(P) binding site [chemical binding]; other site
479433002932	active site
479433002933	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
479433002934	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433002935	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433002936	active site
479433002937	catalytic tetrad [active]
479433002938	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433002939	FAD binding domain; Region: FAD_binding_3; pfam01494
479433002940	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
479433002941	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
479433002942	SchA/CurD like domain; Region: SchA_CurD; pfam04486
479433002943	SchA/CurD like domain; Region: SchA_CurD; pfam04486
479433002944	Cupin domain; Region: Cupin_2; pfam07883
479433002945	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
479433002946	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
479433002947	dimer interface [polypeptide binding]; other site
479433002948	active site
479433002949	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
479433002950	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
479433002951	active site
479433002952	Phosphopantetheine attachment site; Region: PP-binding; cl09936
479433002953	N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860
479433002954	putative hydrophobic ligand binding site [chemical binding]; other site
479433002955	active site
479433002956	catalytic residues_2 [active]
479433002957	catalytic residues_1 [active]
479433002958	Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673
479433002959	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
479433002960	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
479433002961	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
479433002962	carboxyltransferase (CT) interaction site; other site
479433002963	biotinylation site [posttranslational modification]; other site
479433002964	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
479433002965	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
479433002966	ATP-grasp domain; Region: ATP-grasp_4; cl17255
479433002967	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
479433002968	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433002969	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433002970	DNA binding residues [nucleotide binding]
479433002971	dimerization interface [polypeptide binding]; other site
479433002972	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
479433002973	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
479433002974	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
479433002975	dimerization domain swap beta strand [polypeptide binding]; other site
479433002976	regulatory protein interface [polypeptide binding]; other site
479433002977	active site
479433002978	regulatory phosphorylation site [posttranslational modification]; other site
479433002979	Transcriptional regulator [Transcription]; Region: IclR; COG1414
479433002980	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433002981	putative Zn2+ binding site [ion binding]; other site
479433002982	putative DNA binding site [nucleotide binding]; other site
479433002983	Bacterial transcriptional regulator; Region: IclR; pfam01614
479433002984	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
479433002985	amphipathic channel; other site
479433002986	Asn-Pro-Ala signature motifs; other site
479433002987	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
479433002988	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
479433002989	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
479433002990	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
479433002991	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
479433002992	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
479433002993	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
479433002994	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433002995	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433002996	active site
479433002997	catalytic tetrad [active]
479433002998	dihydroxyacetone kinase; Provisional; Region: PRK14479
479433002999	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
479433003000	DAK2 domain; Region: Dak2; pfam02734
479433003001	Short C-terminal domain; Region: SHOCT; pfam09851
479433003002	putative oxidoreductase; Provisional; Region: PRK11579
479433003003	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
479433003004	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
479433003005	dimerization interface [polypeptide binding]; other site
479433003006	putative DNA binding site [nucleotide binding]; other site
479433003007	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
479433003008	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433003009	putative Zn2+ binding site [ion binding]; other site
479433003010	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433003011	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
479433003012	RibD C-terminal domain; Region: RibD_C; pfam01872
479433003013	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
479433003014	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
479433003015	putative hydrophobic ligand binding site [chemical binding]; other site
479433003016	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433003017	dimerization interface [polypeptide binding]; other site
479433003018	putative DNA binding site [nucleotide binding]; other site
479433003019	putative Zn2+ binding site [ion binding]; other site
479433003020	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433003021	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
479433003022	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
479433003023	hydrophobic ligand binding site; other site
479433003024	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
479433003025	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
479433003026	MoxR-like ATPases [General function prediction only]; Region: COG0714
479433003027	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433003028	Walker A motif; other site
479433003029	ATP binding site [chemical binding]; other site
479433003030	Walker B motif; other site
479433003031	arginine finger; other site
479433003032	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
479433003033	Secretory lipase; Region: LIP; pfam03583
479433003034	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
479433003035	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
479433003036	CopC domain; Region: CopC; pfam04234
479433003037	Copper resistance protein D; Region: CopD; pfam05425
479433003038	Beta-lactamase; Region: Beta-lactamase; pfam00144
479433003039	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
479433003040	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
479433003041	FAD binding domain; Region: FAD_binding_4; pfam01565
479433003042	Berberine and berberine like; Region: BBE; pfam08031
479433003043	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
479433003044	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433003045	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433003046	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
479433003047	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433003048	putative DNA binding site [nucleotide binding]; other site
479433003049	putative Zn2+ binding site [ion binding]; other site
479433003050	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
479433003051	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
479433003052	AsnC family; Region: AsnC_trans_reg; pfam01037
479433003053	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433003054	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433003055	active site
479433003056	catalytic tetrad [active]
479433003057	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
479433003058	putative homodimer interface [polypeptide binding]; other site
479433003059	putative homotetramer interface [polypeptide binding]; other site
479433003060	putative allosteric switch controlling residues; other site
479433003061	putative metal binding site [ion binding]; other site
479433003062	putative homodimer-homodimer interface [polypeptide binding]; other site
479433003063	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433003064	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433003065	active site
479433003066	ATP binding site [chemical binding]; other site
479433003067	substrate binding site [chemical binding]; other site
479433003068	activation loop (A-loop); other site
479433003069	von Willebrand factor type A domain; Region: VWA_2; pfam13519
479433003070	metal ion-dependent adhesion site (MIDAS); other site
479433003071	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
479433003072	HSP70 interaction site [polypeptide binding]; other site
479433003073	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
479433003074	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433003075	S-adenosylmethionine binding site [chemical binding]; other site
479433003076	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
479433003077	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
479433003078	metal binding site [ion binding]; metal-binding site
479433003079	putative dimer interface [polypeptide binding]; other site
479433003080	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
479433003081	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
479433003082	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
479433003083	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433003084	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433003085	WHG domain; Region: WHG; pfam13305
479433003086	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
479433003087	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
479433003088	epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247
479433003089	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
479433003090	motif II; other site
479433003091	enoyl-CoA hydratase; Provisional; Region: PRK06210
479433003092	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
479433003093	substrate binding site [chemical binding]; other site
479433003094	oxyanion hole (OAH) forming residues; other site
479433003095	trimer interface [polypeptide binding]; other site
479433003096	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433003097	NAD(P) binding site [chemical binding]; other site
479433003098	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
479433003099	active site
479433003100	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
479433003101	Phosphotransferase enzyme family; Region: APH; pfam01636
479433003102	putative active site [active]
479433003103	putative substrate binding site [chemical binding]; other site
479433003104	ATP binding site [chemical binding]; other site
479433003105	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
479433003106	classical (c) SDRs; Region: SDR_c; cd05233
479433003107	NAD(P) binding site [chemical binding]; other site
479433003108	active site
479433003109	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433003110	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433003111	active site
479433003112	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433003113	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433003114	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433003115	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
479433003116	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433003117	active site
479433003118	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433003119	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433003120	active site
479433003121	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433003122	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433003123	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
479433003124	dimerization interface [polypeptide binding]; other site
479433003125	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
479433003126	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
479433003127	potential catalytic triad [active]
479433003128	conserved cys residue [active]
479433003129	Prostaglandin dehydrogenases; Region: PGDH; cd05288
479433003130	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
479433003131	NAD(P) binding site [chemical binding]; other site
479433003132	substrate binding site [chemical binding]; other site
479433003133	dimer interface [polypeptide binding]; other site
479433003134	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433003135	NADH(P)-binding; Region: NAD_binding_10; pfam13460
479433003136	NAD(P) binding site [chemical binding]; other site
479433003137	active site
479433003138	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433003139	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433003140	active site
479433003141	catalytic tetrad [active]
479433003142	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
479433003143	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
479433003144	Ion channel; Region: Ion_trans_2; pfam07885
479433003145	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
479433003146	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
479433003147	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433003148	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433003149	active site
479433003150	ATP binding site [chemical binding]; other site
479433003151	substrate binding site [chemical binding]; other site
479433003152	activation loop (A-loop); other site
479433003153	coproporphyrinogen III oxidase; Validated; Region: PRK08208
479433003154	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433003155	FeS/SAM binding site; other site
479433003156	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433003157	FeS/SAM binding site; other site
479433003158	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
479433003159	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433003160	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
479433003161	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
479433003162	substrate binding site [chemical binding]; other site
479433003163	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
479433003164	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
479433003165	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433003166	dimer interface [polypeptide binding]; other site
479433003167	conserved gate region; other site
479433003168	putative PBP binding loops; other site
479433003169	ABC-ATPase subunit interface; other site
479433003170	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
479433003171	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433003172	dimer interface [polypeptide binding]; other site
479433003173	conserved gate region; other site
479433003174	putative PBP binding loops; other site
479433003175	ABC-ATPase subunit interface; other site
479433003176	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
479433003177	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433003178	Walker A/P-loop; other site
479433003179	ATP binding site [chemical binding]; other site
479433003180	Q-loop/lid; other site
479433003181	ABC transporter signature motif; other site
479433003182	Walker B; other site
479433003183	D-loop; other site
479433003184	H-loop/switch region; other site
479433003185	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
479433003186	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
479433003187	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433003188	Walker A/P-loop; other site
479433003189	ATP binding site [chemical binding]; other site
479433003190	Q-loop/lid; other site
479433003191	ABC transporter signature motif; other site
479433003192	Walker B; other site
479433003193	D-loop; other site
479433003194	H-loop/switch region; other site
479433003195	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
479433003196	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
479433003197	non-specific DNA interactions [nucleotide binding]; other site
479433003198	DNA binding site [nucleotide binding]
479433003199	sequence specific DNA binding site [nucleotide binding]; other site
479433003200	putative cAMP binding site [chemical binding]; other site
479433003201	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433003202	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
479433003203	nucleotide binding site [chemical binding]; other site
479433003204	SWIM zinc finger; Region: SWIM; pfam04434
479433003205	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
479433003206	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433003207	Fic/DOC family; Region: Fic; cl00960
479433003208	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
479433003209	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
479433003210	putative active site [active]
479433003211	dimerization interface [polypeptide binding]; other site
479433003212	putative tRNAtyr binding site [nucleotide binding]; other site
479433003213	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
479433003214	active site
479433003215	catalytic residues [active]
479433003216	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
479433003217	Predicted transcriptional regulators [Transcription]; Region: COG1695
479433003218	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
479433003219	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433003220	Response regulator receiver domain; Region: Response_reg; pfam00072
479433003221	active site
479433003222	phosphorylation site [posttranslational modification]
479433003223	intermolecular recognition site; other site
479433003224	dimerization interface [polypeptide binding]; other site
479433003225	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
479433003226	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
479433003227	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
479433003228	active site
479433003229	HIGH motif; other site
479433003230	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
479433003231	KMSK motif region; other site
479433003232	tRNA binding surface [nucleotide binding]; other site
479433003233	DALR anticodon binding domain; Region: DALR_1; smart00836
479433003234	anticodon binding site; other site
479433003235	diaminopimelate decarboxylase; Region: lysA; TIGR01048
479433003236	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
479433003237	active site
479433003238	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
479433003239	substrate binding site [chemical binding]; other site
479433003240	catalytic residues [active]
479433003241	dimer interface [polypeptide binding]; other site
479433003242	homoserine dehydrogenase; Provisional; Region: PRK06349
479433003243	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
479433003244	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
479433003245	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
479433003246	threonine synthase; Reviewed; Region: PRK06721
479433003247	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
479433003248	homodimer interface [polypeptide binding]; other site
479433003249	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433003250	catalytic residue [active]
479433003251	homoserine kinase; Provisional; Region: PRK01212
479433003252	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
479433003253	transcription termination factor Rho; Provisional; Region: PRK12608
479433003254	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
479433003255	RNA binding site [nucleotide binding]; other site
479433003256	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
479433003257	multimer interface [polypeptide binding]; other site
479433003258	Walker A motif; other site
479433003259	ATP binding site [chemical binding]; other site
479433003260	Walker B motif; other site
479433003261	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
479433003262	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
479433003263	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
479433003264	peptide chain release factor 1; Validated; Region: prfA; PRK00591
479433003265	This domain is found in peptide chain release factors; Region: PCRF; smart00937
479433003266	RF-1 domain; Region: RF-1; pfam00472
479433003267	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
479433003268	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433003269	S-adenosylmethionine binding site [chemical binding]; other site
479433003270	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
479433003271	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
479433003272	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
479433003273	Mg++ binding site [ion binding]; other site
479433003274	putative catalytic motif [active]
479433003275	substrate binding site [chemical binding]; other site
479433003276	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
479433003277	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
479433003278	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
479433003279	F0F1 ATP synthase subunit C; Validated; Region: PRK07874
479433003280	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
479433003281	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
479433003282	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
479433003283	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
479433003284	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
479433003285	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
479433003286	beta subunit interaction interface [polypeptide binding]; other site
479433003287	Walker A motif; other site
479433003288	ATP binding site [chemical binding]; other site
479433003289	Walker B motif; other site
479433003290	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
479433003291	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
479433003292	core domain interface [polypeptide binding]; other site
479433003293	delta subunit interface [polypeptide binding]; other site
479433003294	epsilon subunit interface [polypeptide binding]; other site
479433003295	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
479433003296	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
479433003297	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
479433003298	alpha subunit interaction interface [polypeptide binding]; other site
479433003299	Walker A motif; other site
479433003300	ATP binding site [chemical binding]; other site
479433003301	Walker B motif; other site
479433003302	inhibitor binding site; inhibition site
479433003303	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
479433003304	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
479433003305	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
479433003306	gamma subunit interface [polypeptide binding]; other site
479433003307	epsilon subunit interface [polypeptide binding]; other site
479433003308	LBP interface [polypeptide binding]; other site
479433003309	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
479433003310	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
479433003311	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
479433003312	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
479433003313	hinge; other site
479433003314	active site
479433003315	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
479433003316	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
479433003317	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
479433003318	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
479433003319	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
479433003320	B12 binding site [chemical binding]; other site
479433003321	cobalt ligand [ion binding]; other site
479433003322	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
479433003323	hypothetical protein; Provisional; Region: PRK03298
479433003324	Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256
479433003325	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
479433003326	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
479433003327	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
479433003328	D-mannose binding lectin; Region: B_lectin; pfam01453
479433003329	mannose binding site [chemical binding]; other site
479433003330	dimerization interface [polypeptide binding]; other site
479433003331	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433003332	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433003333	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433003334	non-specific DNA binding site [nucleotide binding]; other site
479433003335	sequence-specific DNA binding site [nucleotide binding]; other site
479433003336	salt bridge; other site
479433003337	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433003338	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433003339	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433003340	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
479433003341	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
479433003342	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
479433003343	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
479433003344	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
479433003345	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
479433003346	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
479433003347	Methyltransferase domain; Region: Methyltransf_23; pfam13489
479433003348	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433003349	S-adenosylmethionine binding site [chemical binding]; other site
479433003350	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
479433003351	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
479433003352	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
479433003353	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
479433003354	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
479433003355	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
479433003356	Walker A/P-loop; other site
479433003357	ATP binding site [chemical binding]; other site
479433003358	Q-loop/lid; other site
479433003359	ABC transporter signature motif; other site
479433003360	Walker B; other site
479433003361	D-loop; other site
479433003362	H-loop/switch region; other site
479433003363	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
479433003364	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
479433003365	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433003366	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433003367	Walker A/P-loop; other site
479433003368	ATP binding site [chemical binding]; other site
479433003369	Q-loop/lid; other site
479433003370	ABC transporter signature motif; other site
479433003371	Walker B; other site
479433003372	D-loop; other site
479433003373	H-loop/switch region; other site
479433003374	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
479433003375	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
479433003376	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
479433003377	Domain of unknown function DUF20; Region: UPF0118; pfam01594
479433003378	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433003379	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433003380	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433003381	DNA binding residues [nucleotide binding]
479433003382	Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442
479433003383	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
479433003384	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
479433003385	crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
479433003386	NAD(P) binding site [chemical binding]; other site
479433003387	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433003388	Coenzyme A binding pocket [chemical binding]; other site
479433003389	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433003390	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433003391	active site
479433003392	phosphorylation site [posttranslational modification]
479433003393	intermolecular recognition site; other site
479433003394	dimerization interface [polypeptide binding]; other site
479433003395	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433003396	DNA binding residues [nucleotide binding]
479433003397	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433003398	Histidine kinase; Region: HisKA_3; pfam07730
479433003399	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
479433003400	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
479433003401	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
479433003402	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
479433003403	NodB motif; other site
479433003404	putative active site [active]
479433003405	putative catalytic site [active]
479433003406	putative Zn binding site [ion binding]; other site
479433003407	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433003408	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
479433003409	dimer interface [polypeptide binding]; other site
479433003410	substrate binding site [chemical binding]; other site
479433003411	metal binding site [ion binding]; metal-binding site
479433003412	putative acyltransferase; Provisional; Region: PRK05790
479433003413	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
479433003414	dimer interface [polypeptide binding]; other site
479433003415	active site
479433003416	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
479433003417	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
479433003418	Walker A; other site
479433003419	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
479433003420	active site
479433003421	integral membrane protein; Region: integ_memb_HG; TIGR03954
479433003422	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
479433003423	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433003424	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433003425	putative DNA binding site [nucleotide binding]; other site
479433003426	putative Zn2+ binding site [ion binding]; other site
479433003427	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433003428	putative substrate translocation pore; other site
479433003429	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433003430	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
479433003431	Beta-lactamase; Region: Beta-lactamase; pfam00144
479433003432	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
479433003433	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433003434	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
479433003435	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
479433003436	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
479433003437	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
479433003438	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
479433003439	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
479433003440	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433003441	MarR family; Region: MarR; pfam01047
479433003442	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
479433003443	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433003444	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433003445	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
479433003446	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
479433003447	enoyl-CoA hydratase; Provisional; Region: PRK05862
479433003448	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
479433003449	substrate binding site [chemical binding]; other site
479433003450	oxyanion hole (OAH) forming residues; other site
479433003451	trimer interface [polypeptide binding]; other site
479433003452	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
479433003453	Uncharacterized conserved protein [Function unknown]; Region: COG0393
479433003454	Uncharacterized conserved protein [Function unknown]; Region: COG0393
479433003455	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
479433003456	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433003457	dimer interface [polypeptide binding]; other site
479433003458	conserved gate region; other site
479433003459	putative PBP binding loops; other site
479433003460	ABC-ATPase subunit interface; other site
479433003461	The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506
479433003462	peptide binding site [polypeptide binding]; other site
479433003463	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
479433003464	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
479433003465	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433003466	dimer interface [polypeptide binding]; other site
479433003467	conserved gate region; other site
479433003468	putative PBP binding loops; other site
479433003469	ABC-ATPase subunit interface; other site
479433003470	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
479433003471	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433003472	dimer interface [polypeptide binding]; other site
479433003473	conserved gate region; other site
479433003474	putative PBP binding loops; other site
479433003475	ABC-ATPase subunit interface; other site
479433003476	The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506
479433003477	peptide binding site [polypeptide binding]; other site
479433003478	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
479433003479	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
479433003480	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433003481	dimer interface [polypeptide binding]; other site
479433003482	conserved gate region; other site
479433003483	putative PBP binding loops; other site
479433003484	ABC-ATPase subunit interface; other site
479433003485	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
479433003486	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433003487	Walker A/P-loop; other site
479433003488	ATP binding site [chemical binding]; other site
479433003489	Q-loop/lid; other site
479433003490	ABC transporter signature motif; other site
479433003491	Walker B; other site
479433003492	D-loop; other site
479433003493	H-loop/switch region; other site
479433003494	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
479433003495	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
479433003496	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433003497	Walker A/P-loop; other site
479433003498	ATP binding site [chemical binding]; other site
479433003499	Q-loop/lid; other site
479433003500	ABC transporter signature motif; other site
479433003501	Walker B; other site
479433003502	D-loop; other site
479433003503	H-loop/switch region; other site
479433003504	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
479433003505	Proteins of 100 residues with WXG; Region: WXG100; cl02005
479433003506	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
479433003507	Ligand binding site [chemical binding]; other site
479433003508	Electron transfer flavoprotein domain; Region: ETF; pfam01012
479433003509	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
479433003510	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
479433003511	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
479433003512	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433003513	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433003514	active site
479433003515	ATP binding site [chemical binding]; other site
479433003516	substrate binding site [chemical binding]; other site
479433003517	activation loop (A-loop); other site
479433003518	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
479433003519	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
479433003520	active site
479433003521	catalytic triad [active]
479433003522	oxyanion hole [active]
479433003523	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
479433003524	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
479433003525	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433003526	catalytic residue [active]
479433003527	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
479433003528	homodimer interaction site [polypeptide binding]; other site
479433003529	cofactor binding site; other site
479433003530	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
479433003531	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
479433003532	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
479433003533	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
479433003534	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
479433003535	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
479433003536	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
479433003537	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433003538	MarR family; Region: MarR_2; pfam12802
479433003539	Predicted flavoprotein [General function prediction only]; Region: COG0431
479433003540	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
479433003541	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
479433003542	Ligase N family; Region: LIGANc; smart00532
479433003543	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
479433003544	nucleotide binding pocket [chemical binding]; other site
479433003545	K-X-D-G motif; other site
479433003546	catalytic site [active]
479433003547	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
479433003548	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
479433003549	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
479433003550	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
479433003551	Dimer interface [polypeptide binding]; other site
479433003552	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
479433003553	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
479433003554	metal binding site [ion binding]; metal-binding site
479433003555	active site
479433003556	I-site; other site
479433003557	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
479433003558	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
479433003559	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433003560	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433003561	active site
479433003562	ATP binding site [chemical binding]; other site
479433003563	substrate binding site [chemical binding]; other site
479433003564	activation loop (A-loop); other site
479433003565	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
479433003566	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
479433003567	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
479433003568	Predicted ATPase [General function prediction only]; Region: COG4637
479433003569	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433003570	Walker A/P-loop; other site
479433003571	ATP binding site [chemical binding]; other site
479433003572	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433003573	Walker B; other site
479433003574	D-loop; other site
479433003575	H-loop/switch region; other site
479433003576	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
479433003577	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
479433003578	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
479433003579	GatB domain; Region: GatB_Yqey; smart00845
479433003580	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
479433003581	D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284
479433003582	NAD binding site [chemical binding]; other site
479433003583	substrate binding site [chemical binding]; other site
479433003584	catalytic Zn binding site [ion binding]; other site
479433003585	structural Zn binding site [ion binding]; other site
479433003586	Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869
479433003587	dimer interface [polypeptide binding]; other site
479433003588	putative active site [active]
479433003589	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
479433003590	active site
479433003591	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
479433003592	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433003593	NAD(P) binding site [chemical binding]; other site
479433003594	active site
479433003595	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433003596	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433003597	putative sugar binding sites [chemical binding]; other site
479433003598	Q-X-W motif; other site
479433003599	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
479433003600	active site
479433003601	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433003602	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433003603	putative sugar binding sites [chemical binding]; other site
479433003604	Q-X-W motif; other site
479433003605	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433003606	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433003607	DNA binding site [nucleotide binding]
479433003608	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
479433003609	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
479433003610	Domain of unknown function (DUF4265); Region: DUF4265; pfam14085
479433003611	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
479433003612	active site
479433003613	catalytic triad [active]
479433003614	oxyanion hole [active]
479433003615	Predicted transcriptional regulator [Transcription]; Region: COG2378
479433003616	HTH domain; Region: HTH_11; pfam08279
479433003617	WYL domain; Region: WYL; pfam13280
479433003618	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
479433003619	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
479433003620	HIGH motif; other site
479433003621	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
479433003622	active site
479433003623	KMSKS motif; other site
479433003624	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
479433003625	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
479433003626	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
479433003627	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
479433003628	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433003629	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433003630	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
479433003631	dimerization interface [polypeptide binding]; other site
479433003632	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
479433003633	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
479433003634	catalytic residues [active]
479433003635	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
479433003636	homodimer interface [polypeptide binding]; other site
479433003637	chemical substrate binding site [chemical binding]; other site
479433003638	oligomer interface [polypeptide binding]; other site
479433003639	metal binding site [ion binding]; metal-binding site
479433003640	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433003641	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433003642	DNA binding site [nucleotide binding]
479433003643	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433003644	ligand binding site [chemical binding]; other site
479433003645	dimerization interface [polypeptide binding]; other site
479433003646	N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786
479433003647	active site
479433003648	catalytic site [active]
479433003649	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
479433003650	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
479433003651	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
479433003652	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
479433003653	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433003654	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433003655	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
479433003656	beta-galactosidase; Region: BGL; TIGR03356
479433003657	TIGR02452 family protein; Region: TIGR02452
479433003658	Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021
479433003659	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433003660	S-adenosylmethionine binding site [chemical binding]; other site
479433003661	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
479433003662	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
479433003663	TAP-like protein; Region: Abhydrolase_4; pfam08386
479433003664	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
479433003665	kynureninase; Region: kynureninase; TIGR01814
479433003666	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433003667	catalytic residue [active]
479433003668	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433003669	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433003670	active site
479433003671	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433003672	S-adenosylmethionine binding site [chemical binding]; other site
479433003673	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
479433003674	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
479433003675	Na binding site [ion binding]; other site
479433003676	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
479433003677	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
479433003678	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433003679	active site
479433003680	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
479433003681	Predicted transcriptional regulators [Transcription]; Region: COG1695
479433003682	Transcriptional regulator PadR-like family; Region: PadR; cl17335
479433003683	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
479433003684	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
479433003685	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433003686	active site
479433003687	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433003688	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
479433003689	FAD binding site [chemical binding]; other site
479433003690	substrate binding site [chemical binding]; other site
479433003691	catalytic base [active]
479433003692	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433003693	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
479433003694	FAD binding site [chemical binding]; other site
479433003695	substrate binding site [chemical binding]; other site
479433003696	catalytic base [active]
479433003697	short chain dehydrogenase; Provisional; Region: PRK07831
479433003698	classical (c) SDRs; Region: SDR_c; cd05233
479433003699	NAD(P) binding site [chemical binding]; other site
479433003700	active site
479433003701	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433003702	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433003703	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
479433003704	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
479433003705	dimer interface [polypeptide binding]; other site
479433003706	active site
479433003707	Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781
479433003708	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
479433003709	Fatty acid desaturase; Region: FA_desaturase; pfam00487
479433003710	Di-iron ligands [ion binding]; other site
479433003711	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
479433003712	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
479433003713	Mg++ binding site [ion binding]; other site
479433003714	putative catalytic motif [active]
479433003715	putative substrate binding site [chemical binding]; other site
479433003716	Hemerythrin-like domain; Region: Hr-like; cd12108
479433003717	Fe binding site [ion binding]; other site
479433003718	Predicted transcriptional regulator [Transcription]; Region: COG2378
479433003719	HTH domain; Region: HTH_11; pfam08279
479433003720	WYL domain; Region: WYL; pfam13280
479433003721	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
479433003722	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
479433003723	Nitronate monooxygenase; Region: NMO; pfam03060
479433003724	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
479433003725	FMN binding site [chemical binding]; other site
479433003726	substrate binding site [chemical binding]; other site
479433003727	putative catalytic residue [active]
479433003728	Coenzyme A transferase; Region: CoA_trans; cl17247
479433003729	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
479433003730	enoyl-CoA hydratase; Provisional; Region: PRK06495
479433003731	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
479433003732	substrate binding site [chemical binding]; other site
479433003733	oxyanion hole (OAH) forming residues; other site
479433003734	trimer interface [polypeptide binding]; other site
479433003735	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433003736	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
479433003737	Walker A/P-loop; other site
479433003738	ATP binding site [chemical binding]; other site
479433003739	Q-loop/lid; other site
479433003740	ABC transporter signature motif; other site
479433003741	Walker B; other site
479433003742	D-loop; other site
479433003743	H-loop/switch region; other site
479433003744	ABC-2 type transporter; Region: ABC2_membrane; cl17235
479433003745	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
479433003746	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
479433003747	DNA binding site [nucleotide binding]
479433003748	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433003749	short chain dehydrogenase; Provisional; Region: PRK06949
479433003750	classical (c) SDRs; Region: SDR_c; cd05233
479433003751	NAD(P) binding site [chemical binding]; other site
479433003752	active site
479433003753	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433003754	short chain dehydrogenase; Provisional; Region: PRK07791
479433003755	NAD(P) binding site [chemical binding]; other site
479433003756	active site
479433003757	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
479433003758	active site
479433003759	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433003760	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433003761	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433003762	DNA binding residues [nucleotide binding]
479433003763	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
479433003764	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
479433003765	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
479433003766	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
479433003767	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
479433003768	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
479433003769	FOG: CBS domain [General function prediction only]; Region: COG0517
479433003770	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624
479433003771	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
479433003772	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
479433003773	active site
479433003774	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433003775	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433003776	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
479433003777	dinuclear metal binding motif [ion binding]; other site
479433003778	Protein of unknown function (DUF4241); Region: DUF4241; pfam14025
479433003779	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
479433003780	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
479433003781	phosphopeptide binding site; other site
479433003782	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
479433003783	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433003784	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433003785	active site
479433003786	ATP binding site [chemical binding]; other site
479433003787	substrate binding site [chemical binding]; other site
479433003788	activation loop (A-loop); other site
479433003789	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433003790	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433003791	active site
479433003792	ATP binding site [chemical binding]; other site
479433003793	substrate binding site [chemical binding]; other site
479433003794	activation loop (A-loop); other site
479433003795	peptide chain release factor 2; Validated; Region: prfB; PRK00578
479433003796	This domain is found in peptide chain release factors; Region: PCRF; smart00937
479433003797	RF-1 domain; Region: RF-1; pfam00472
479433003798	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
479433003799	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433003800	Walker A/P-loop; other site
479433003801	ATP binding site [chemical binding]; other site
479433003802	Q-loop/lid; other site
479433003803	ABC transporter signature motif; other site
479433003804	Walker B; other site
479433003805	D-loop; other site
479433003806	H-loop/switch region; other site
479433003807	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
479433003808	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
479433003809	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
479433003810	SmpB-tmRNA interface; other site
479433003811	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
479433003812	Restriction endonuclease; Region: Mrr_cat; pfam04471
479433003813	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
479433003814	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
479433003815	ATP binding site [chemical binding]; other site
479433003816	putative Mg++ binding site [ion binding]; other site
479433003817	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
479433003818	nucleotide binding region [chemical binding]; other site
479433003819	ATP-binding site [chemical binding]; other site
479433003820	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
479433003821	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
479433003822	ATP binding site [chemical binding]; other site
479433003823	Mg2+ binding site [ion binding]; other site
479433003824	G-X-G motif; other site
479433003825	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
479433003826	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
479433003827	cofactor binding site; other site
479433003828	DNA binding site [nucleotide binding]
479433003829	substrate interaction site [chemical binding]; other site
479433003830	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
479433003831	mismatch recognition site; other site
479433003832	additional DNA contacts [nucleotide binding]; other site
479433003833	active site
479433003834	zinc binding site [ion binding]; other site
479433003835	DNA intercalation site [nucleotide binding]; other site
479433003836	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
479433003837	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
479433003838	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433003839	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433003840	active site
479433003841	catalytic tetrad [active]
479433003842	flagellin; Validated; Region: PRK08026
479433003843	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433003844	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433003845	DNA binding residues [nucleotide binding]
479433003846	dimerization interface [polypeptide binding]; other site
479433003847	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
479433003848	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672
479433003849	AAA ATPase domain; Region: AAA_16; pfam13191
479433003850	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
479433003851	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180
479433003852	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
479433003853	active site
479433003854	DNA binding site [nucleotide binding]
479433003855	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
479433003856	DNA binding site [nucleotide binding]
479433003857	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433003858	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433003859	DNA binding residues [nucleotide binding]
479433003860	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433003861	S-adenosylmethionine binding site [chemical binding]; other site
479433003862	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
479433003863	nudix motif; other site
479433003864	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
479433003865	extended (e) SDRs; Region: SDR_e; cd08946
479433003866	NAD(P) binding site [chemical binding]; other site
479433003867	active site
479433003868	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433003869	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433003870	DNA binding site [nucleotide binding]
479433003871	domain linker motif; other site
479433003872	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433003873	dimerization interface [polypeptide binding]; other site
479433003874	ligand binding site [chemical binding]; other site
479433003875	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
479433003876	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
479433003877	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
479433003878	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
479433003879	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433003880	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433003881	DNA binding site [nucleotide binding]
479433003882	domain linker motif; other site
479433003883	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433003884	dimerization interface [polypeptide binding]; other site
479433003885	ligand binding site [chemical binding]; other site
479433003886	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
479433003887	EamA-like transporter family; Region: EamA; pfam00892
479433003888	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433003889	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
479433003890	hypothetical protein; Provisional; Region: PRK07907
479433003891	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
479433003892	active site
479433003893	metal binding site [ion binding]; metal-binding site
479433003894	dimer interface [polypeptide binding]; other site
479433003895	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433003896	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433003897	putative substrate translocation pore; other site
479433003898	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433003899	Uncharacterized conserved protein [Function unknown]; Region: COG3379
479433003900	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
479433003901	ribonuclease Z; Reviewed; Region: PRK00055
479433003902	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433003903	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433003904	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
479433003905	active site residue [active]
479433003906	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
479433003907	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
479433003908	ligand binding site [chemical binding]; other site
479433003909	flexible hinge region; other site
479433003910	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
479433003911	active site
479433003912	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
479433003913	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
479433003914	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433003915	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
479433003916	dimerization interface [polypeptide binding]; other site
479433003917	substrate binding pocket [chemical binding]; other site
479433003918	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
479433003919	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
479433003920	Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403
479433003921	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
479433003922	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
479433003923	apolar tunnel; other site
479433003924	heme binding site [chemical binding]; other site
479433003925	dimerization interface [polypeptide binding]; other site
479433003926	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
479433003927	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
479433003928	Transcriptional regulators [Transcription]; Region: FadR; COG2186
479433003929	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433003930	DNA-binding site [nucleotide binding]; DNA binding site
479433003931	FCD domain; Region: FCD; pfam07729
479433003932	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
479433003933	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
479433003934	TM-ABC transporter signature motif; other site
479433003935	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
479433003936	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
479433003937	Walker A/P-loop; other site
479433003938	ATP binding site [chemical binding]; other site
479433003939	Q-loop/lid; other site
479433003940	ABC transporter signature motif; other site
479433003941	Walker B; other site
479433003942	D-loop; other site
479433003943	H-loop/switch region; other site
479433003944	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
479433003945	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
479433003946	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
479433003947	ligand binding site [chemical binding]; other site
479433003948	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
479433003949	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
479433003950	Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324
479433003951	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
479433003952	putative active site pocket [active]
479433003953	metal binding site [ion binding]; metal-binding site
479433003954	classical (c) SDRs; Region: SDR_c; cd05233
479433003955	NAD(P) binding site [chemical binding]; other site
479433003956	active site
479433003957	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433003958	active site
479433003959	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433003960	catalytic tetrad [active]
479433003961	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
479433003962	Cysteine-rich domain; Region: CCG; pfam02754
479433003963	Cysteine-rich domain; Region: CCG; pfam02754
479433003964	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
479433003965	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
479433003966	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
479433003967	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
479433003968	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
479433003969	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
479433003970	NAD binding site [chemical binding]; other site
479433003971	homodimer interface [polypeptide binding]; other site
479433003972	active site
479433003973	substrate binding site [chemical binding]; other site
479433003974	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
479433003975	DNA-binding site [nucleotide binding]; DNA binding site
479433003976	RNA-binding motif; other site
479433003977	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
479433003978	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
479433003979	Malic enzyme, N-terminal domain; Region: malic; pfam00390
479433003980	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
479433003981	putative NAD(P) binding site [chemical binding]; other site
479433003982	Domain of unknown function (DUF385); Region: DUF385; cl04387
479433003983	putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208
479433003984	oligomer interface [polypeptide binding]; other site
479433003985	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
479433003986	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
479433003987	hinge; other site
479433003988	active site
479433003989	hypothetical protein; Validated; Region: PRK00228
479433003990	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
479433003991	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
479433003992	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
479433003993	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
479433003994	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
479433003995	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
479433003996	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
479433003997	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
479433003998	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
479433003999	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
479433004000	ATP binding site [chemical binding]; other site
479433004001	putative Mg++ binding site [ion binding]; other site
479433004002	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433004003	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433004004	Cupin domain; Region: Cupin_2; pfam07883
479433004005	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
479433004006	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433004007	Domain of unknown function (DUF385); Region: DUF385; cl04387
479433004008	Transcriptional regulator [Transcription]; Region: IclR; COG1414
479433004009	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
479433004010	Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752
479433004011	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
479433004012	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
479433004013	AsnC family; Region: AsnC_trans_reg; pfam01037
479433004014	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
479433004015	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
479433004016	dimer interface [polypeptide binding]; other site
479433004017	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
479433004018	active site
479433004019	Fe binding site [ion binding]; other site
479433004020	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
479433004021	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
479433004022	Isochorismatase family; Region: Isochorismatase; pfam00857
479433004023	catalytic triad [active]
479433004024	metal binding site [ion binding]; metal-binding site
479433004025	conserved cis-peptide bond; other site
479433004026	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
479433004027	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
479433004028	active site
479433004029	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
479433004030	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
479433004031	Small secreted domain (DUF320); Region: DUF320; pfam03777
479433004032	Small secreted domain (DUF320); Region: DUF320; pfam03777
479433004033	Small secreted domain (DUF320); Region: DUF320; pfam03777
479433004034	Small secreted domain (DUF320); Region: DUF320; pfam03777
479433004035	Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
479433004036	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
479433004037	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433004038	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
479433004039	TAP-like protein; Region: Abhydrolase_4; pfam08386
479433004040	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
479433004041	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
479433004042	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
479433004043	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433004044	non-specific DNA binding site [nucleotide binding]; other site
479433004045	salt bridge; other site
479433004046	sequence-specific DNA binding site [nucleotide binding]; other site
479433004047	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433004048	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
479433004049	Domain of unknown function (DUF397); Region: DUF397; pfam04149
479433004050	amidase; Provisional; Region: PRK12470
479433004051	Amidase; Region: Amidase; cl11426
479433004052	Amidase; Region: Amidase; cl11426
479433004053	GMP synthase; Reviewed; Region: guaA; PRK00074
479433004054	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
479433004055	AMP/PPi binding site [chemical binding]; other site
479433004056	candidate oxyanion hole; other site
479433004057	catalytic triad [active]
479433004058	potential glutamine specificity residues [chemical binding]; other site
479433004059	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
479433004060	ATP Binding subdomain [chemical binding]; other site
479433004061	Ligand Binding sites [chemical binding]; other site
479433004062	Dimerization subdomain; other site
479433004063	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
479433004064	NlpC/P60 family; Region: NLPC_P60; pfam00877
479433004065	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
479433004066	active site
479433004067	catalytic site [active]
479433004068	substrate binding site [chemical binding]; other site
479433004069	signal recognition particle protein; Provisional; Region: PRK10867
479433004070	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
479433004071	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
479433004072	P loop; other site
479433004073	GTP binding site [chemical binding]; other site
479433004074	Signal peptide binding domain; Region: SRP_SPB; pfam02978
479433004075	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
479433004076	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
479433004077	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
479433004078	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
479433004079	RimM N-terminal domain; Region: RimM; pfam01782
479433004080	PRC-barrel domain; Region: PRC; pfam05239
479433004081	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
479433004082	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
479433004083	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
479433004084	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
479433004085	Catalytic site [active]
479433004086	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
479433004087	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
479433004088	Catalytic site [active]
479433004089	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
479433004090	RNA/DNA hybrid binding site [nucleotide binding]; other site
479433004091	active site
479433004092	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
479433004093	hypothetical protein; Reviewed; Region: PRK12497
479433004094	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
479433004095	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
479433004096	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
479433004097	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
479433004098	DNA protecting protein DprA; Region: dprA; TIGR00732
479433004099	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
479433004100	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
479433004101	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
479433004102	active site
479433004103	DNA binding site [nucleotide binding]
479433004104	Int/Topo IB signature motif; other site
479433004105	RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288
479433004106	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433004107	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
479433004108	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433004109	DNA binding residues [nucleotide binding]
479433004110	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433004111	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433004112	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
479433004113	Peptidase family M23; Region: Peptidase_M23; pfam01551
479433004114	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
479433004115	rRNA interaction site [nucleotide binding]; other site
479433004116	S8 interaction site; other site
479433004117	putative laminin-1 binding site; other site
479433004118	elongation factor Ts; Provisional; Region: tsf; PRK09377
479433004119	UBA/TS-N domain; Region: UBA; pfam00627
479433004120	Elongation factor TS; Region: EF_TS; pfam00889
479433004121	Elongation factor TS; Region: EF_TS; pfam00889
479433004122	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
479433004123	putative nucleotide binding site [chemical binding]; other site
479433004124	uridine monophosphate binding site [chemical binding]; other site
479433004125	homohexameric interface [polypeptide binding]; other site
479433004126	ribosome recycling factor; Reviewed; Region: frr; PRK00083
479433004127	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
479433004128	hinge region; other site
479433004129	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
479433004130	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
479433004131	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433004132	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
479433004133	Predicted transcriptional regulators [Transcription]; Region: COG1695
479433004134	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
479433004135	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
479433004136	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433004137	FeS/SAM binding site; other site
479433004138	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
479433004139	putative dimer interface [polypeptide binding]; other site
479433004140	ligand binding site [chemical binding]; other site
479433004141	Zn binding site [ion binding]; other site
479433004142	NADH(P)-binding; Region: NAD_binding_10; pfam13460
479433004143	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433004144	NAD(P) binding site [chemical binding]; other site
479433004145	active site
479433004146	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
479433004147	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
479433004148	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433004149	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
479433004150	Walker A/P-loop; other site
479433004151	ATP binding site [chemical binding]; other site
479433004152	Q-loop/lid; other site
479433004153	ABC transporter signature motif; other site
479433004154	Walker B; other site
479433004155	D-loop; other site
479433004156	H-loop/switch region; other site
479433004157	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433004158	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
479433004159	Walker A/P-loop; other site
479433004160	ATP binding site [chemical binding]; other site
479433004161	Q-loop/lid; other site
479433004162	ABC transporter signature motif; other site
479433004163	Walker B; other site
479433004164	D-loop; other site
479433004165	H-loop/switch region; other site
479433004166	short chain dehydrogenase; Provisional; Region: PRK06197
479433004167	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
479433004168	putative NAD(P) binding site [chemical binding]; other site
479433004169	active site
479433004170	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433004171	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
479433004172	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
479433004173	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
479433004174	hypothetical protein; Provisional; Region: PRK06541
479433004175	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
479433004176	inhibitor-cofactor binding pocket; inhibition site
479433004177	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433004178	catalytic residue [active]
479433004179	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
479433004180	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
479433004181	AsnC family; Region: AsnC_trans_reg; pfam01037
479433004182	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
479433004183	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
479433004184	tetrameric interface [polypeptide binding]; other site
479433004185	NAD binding site [chemical binding]; other site
479433004186	catalytic residues [active]
479433004187	substrate binding site [chemical binding]; other site
479433004188	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433004189	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433004190	putative substrate translocation pore; other site
479433004191	envelope glycoprotein C; Provisional; Region: PHA03269
479433004192	NACHT domain; Region: NACHT; pfam05729
479433004193	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433004194	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433004195	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433004196	binding surface
479433004197	TPR motif; other site
479433004198	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433004199	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433004200	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
479433004201	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
479433004202	dimer interface [polypeptide binding]; other site
479433004203	TPP-binding site [chemical binding]; other site
479433004204	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
479433004205	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
479433004206	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
479433004207	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
479433004208	dimer interface [polypeptide binding]; other site
479433004209	catalytic triad [active]
479433004210	Protein of unknown function (DUF1407); Region: DUF1407; pfam07191
479433004211	Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110
479433004212	Tellurium resistance protein; Region: Tellurium_res; pfam10138
479433004213	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
479433004214	putative metal binding site [ion binding]; other site
479433004215	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
479433004216	transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481
479433004217	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433004218	DNA-binding site [nucleotide binding]; DNA binding site
479433004219	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
479433004220	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433004221	catalytic residue [active]
479433004222	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
479433004223	acetyl-CoA acetyltransferase; Provisional; Region: PRK07850
479433004224	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
479433004225	dimer interface [polypeptide binding]; other site
479433004226	active site
479433004227	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
479433004228	catalytic core [active]
479433004229	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
479433004230	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
479433004231	substrate binding pocket [chemical binding]; other site
479433004232	chain length determination region; other site
479433004233	substrate-Mg2+ binding site; other site
479433004234	catalytic residues [active]
479433004235	aspartate-rich region 1; other site
479433004236	active site lid residues [active]
479433004237	aspartate-rich region 2; other site
479433004238	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
479433004239	FAD binding site [chemical binding]; other site
479433004240	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433004241	Coenzyme A binding pocket [chemical binding]; other site
479433004242	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
479433004243	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
479433004244	active site
479433004245	hypothetical protein; Provisional; Region: PRK10621
479433004246	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
479433004247	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
479433004248	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
479433004249	ATP binding site [chemical binding]; other site
479433004250	putative Mg++ binding site [ion binding]; other site
479433004251	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
479433004252	nucleotide binding region [chemical binding]; other site
479433004253	ATP-binding site [chemical binding]; other site
479433004254	DEAD/H associated; Region: DEAD_assoc; pfam08494
479433004255	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
479433004256	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433004257	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433004258	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433004259	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433004260	recombinase A; Provisional; Region: recA; PRK09354
479433004261	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
479433004262	hexamer interface [polypeptide binding]; other site
479433004263	Walker A motif; other site
479433004264	ATP binding site [chemical binding]; other site
479433004265	Walker B motif; other site
479433004266	recombination regulator RecX; Reviewed; Region: recX; PRK00117
479433004267	Domain of unknown function (DUF3552); Region: DUF3552; pfam12072
479433004268	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
479433004269	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
479433004270	Zn2+ binding site [ion binding]; other site
479433004271	Mg2+ binding site [ion binding]; other site
479433004272	Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827
479433004273	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433004274	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433004275	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
479433004276	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433004277	salt bridge; other site
479433004278	non-specific DNA binding site [nucleotide binding]; other site
479433004279	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433004280	sequence-specific DNA binding site [nucleotide binding]; other site
479433004281	translocation protein TolB; Provisional; Region: tolB; PRK02889
479433004282	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433004283	MarR family; Region: MarR_2; cl17246
479433004284	Isochorismatase family; Region: Isochorismatase; pfam00857
479433004285	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
479433004286	catalytic triad [active]
479433004287	conserved cis-peptide bond; other site
479433004288	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433004289	S-adenosylmethionine binding site [chemical binding]; other site
479433004290	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433004291	non-specific DNA binding site [nucleotide binding]; other site
479433004292	salt bridge; other site
479433004293	sequence-specific DNA binding site [nucleotide binding]; other site
479433004294	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752
479433004295	Homeodomain-like domain; Region: HTH_23; pfam13384
479433004296	Winged helix-turn helix; Region: HTH_29; pfam13551
479433004297	Homeodomain-like domain; Region: HTH_32; pfam13565
479433004298	MarR family; Region: MarR_2; pfam12802
479433004299	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433004300	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433004301	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
479433004302	nucleotide binding site [chemical binding]; other site
479433004303	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
479433004304	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
479433004305	active site
479433004306	catalytic site [active]
479433004307	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
479433004308	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
479433004309	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
479433004310	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433004311	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
479433004312	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433004313	putative PBP binding loops; other site
479433004314	dimer interface [polypeptide binding]; other site
479433004315	ABC-ATPase subunit interface; other site
479433004316	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433004317	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433004318	dimer interface [polypeptide binding]; other site
479433004319	conserved gate region; other site
479433004320	putative PBP binding loops; other site
479433004321	ABC-ATPase subunit interface; other site
479433004322	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
479433004323	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
479433004324	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
479433004325	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
479433004326	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167
479433004327	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
479433004328	putative ligand binding site [chemical binding]; other site
479433004329	putative NAD binding site [chemical binding]; other site
479433004330	catalytic site [active]
479433004331	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
479433004332	Prostaglandin dehydrogenases; Region: PGDH; cd05288
479433004333	NAD(P) binding site [chemical binding]; other site
479433004334	substrate binding site [chemical binding]; other site
479433004335	dimer interface [polypeptide binding]; other site
479433004336	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433004337	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433004338	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
479433004339	dimerization interface [polypeptide binding]; other site
479433004340	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
479433004341	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
479433004342	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
479433004343	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
479433004344	sugar binding site [chemical binding]; other site
479433004345	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
479433004346	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
479433004347	sugar binding site [chemical binding]; other site
479433004348	Alginate lyase; Region: Alginate_lyase2; pfam08787
479433004349	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
479433004350	putative metal binding site [ion binding]; other site
479433004351	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
479433004352	putative metal binding site [ion binding]; other site
479433004353	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433004354	sugar binding site [chemical binding]; other site
479433004355	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
479433004356	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
479433004357	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
479433004358	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
479433004359	threonine dehydratase; Provisional; Region: PRK08246
479433004360	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
479433004361	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433004362	catalytic residue [active]
479433004363	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
479433004364	Beta-lactamase; Region: Beta-lactamase; pfam00144
479433004365	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
479433004366	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433004367	Coenzyme A binding pocket [chemical binding]; other site
479433004368	FtsX-like permease family; Region: FtsX; pfam02687
479433004369	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
479433004370	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
479433004371	FtsX-like permease family; Region: FtsX; pfam02687
479433004372	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
479433004373	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
479433004374	Walker A/P-loop; other site
479433004375	ATP binding site [chemical binding]; other site
479433004376	Q-loop/lid; other site
479433004377	ABC transporter signature motif; other site
479433004378	Walker B; other site
479433004379	D-loop; other site
479433004380	H-loop/switch region; other site
479433004381	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433004382	Histidine kinase; Region: HisKA_3; pfam07730
479433004383	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433004384	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433004385	active site
479433004386	phosphorylation site [posttranslational modification]
479433004387	intermolecular recognition site; other site
479433004388	dimerization interface [polypeptide binding]; other site
479433004389	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433004390	DNA binding residues [nucleotide binding]
479433004391	dimerization interface [polypeptide binding]; other site
479433004392	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
479433004393	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
479433004394	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433004395	FeS/SAM binding site; other site
479433004396	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433004397	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433004398	active site
479433004399	ATP binding site [chemical binding]; other site
479433004400	substrate binding site [chemical binding]; other site
479433004401	activation loop (A-loop); other site
479433004402	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
479433004403	active site
479433004404	metal binding site [ion binding]; metal-binding site
479433004405	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
479433004406	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
479433004407	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
479433004408	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
479433004409	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
479433004410	ferrochelatase; Reviewed; Region: hemH; PRK00035
479433004411	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
479433004412	C-terminal domain interface [polypeptide binding]; other site
479433004413	active site
479433004414	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
479433004415	active site
479433004416	N-terminal domain interface [polypeptide binding]; other site
479433004417	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
479433004418	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
479433004419	active site
479433004420	dimerization interface [polypeptide binding]; other site
479433004421	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433004422	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433004423	active site
479433004424	phosphorylation site [posttranslational modification]
479433004425	intermolecular recognition site; other site
479433004426	dimerization interface [polypeptide binding]; other site
479433004427	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433004428	DNA binding site [nucleotide binding]
479433004429	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433004430	HAMP domain; Region: HAMP; pfam00672
479433004431	dimerization interface [polypeptide binding]; other site
479433004432	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433004433	dimer interface [polypeptide binding]; other site
479433004434	phosphorylation site [posttranslational modification]
479433004435	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433004436	ATP binding site [chemical binding]; other site
479433004437	Mg2+ binding site [ion binding]; other site
479433004438	G-X-G motif; other site
479433004439	Domain of unknown function DUF77; Region: DUF77; pfam01910
479433004440	Flavoprotein; Region: Flavoprotein; pfam02441
479433004441	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433004442	sequence-specific DNA binding site [nucleotide binding]; other site
479433004443	salt bridge; other site
479433004444	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
479433004445	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
479433004446	trimer interface [polypeptide binding]; other site
479433004447	putative metal binding site [ion binding]; other site
479433004448	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
479433004449	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
479433004450	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
479433004451	active site 2 [active]
479433004452	active site 1 [active]
479433004453	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
479433004454	trimer interface [polypeptide binding]; other site
479433004455	active site
479433004456	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
479433004457	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
479433004458	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
479433004459	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
479433004460	TrkA-N domain; Region: TrkA_N; pfam02254
479433004461	TrkA-C domain; Region: TrkA_C; pfam02080
479433004462	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
479433004463	TrkA-N domain; Region: TrkA_N; pfam02254
479433004464	TrkA-C domain; Region: TrkA_C; pfam02080
479433004465	TRAM domain; Region: TRAM; pfam01938
479433004466	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
479433004467	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433004468	S-adenosylmethionine binding site [chemical binding]; other site
479433004469	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
479433004470	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
479433004471	dimer interface [polypeptide binding]; other site
479433004472	active site
479433004473	glycine-pyridoxal phosphate binding site [chemical binding]; other site
479433004474	folate binding site [chemical binding]; other site
479433004475	Pirin-related protein [General function prediction only]; Region: COG1741
479433004476	Pirin; Region: Pirin; pfam02678
479433004477	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
479433004478	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
479433004479	active site
479433004480	DNA polymerase IV; Validated; Region: PRK02406
479433004481	DNA binding site [nucleotide binding]
479433004482	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433004483	Coenzyme A binding pocket [chemical binding]; other site
479433004484	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433004485	S-adenosylmethionine binding site [chemical binding]; other site
479433004486	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
479433004487	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
479433004488	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
479433004489	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
479433004490	Protein of unknown function DUF58; Region: DUF58; pfam01882
479433004491	MoxR-like ATPases [General function prediction only]; Region: COG0714
479433004492	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433004493	Walker A motif; other site
479433004494	ATP binding site [chemical binding]; other site
479433004495	Walker B motif; other site
479433004496	arginine finger; other site
479433004497	cell division protein MraZ; Reviewed; Region: PRK00326
479433004498	MraZ protein; Region: MraZ; pfam02381
479433004499	MraZ protein; Region: MraZ; pfam02381
479433004500	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
479433004501	MraW methylase family; Region: Methyltransf_5; pfam01795
479433004502	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
479433004503	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
479433004504	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
479433004505	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
479433004506	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
479433004507	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
479433004508	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
479433004509	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
479433004510	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
479433004511	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
479433004512	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
479433004513	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
479433004514	Mg++ binding site [ion binding]; other site
479433004515	putative catalytic motif [active]
479433004516	putative substrate binding site [chemical binding]; other site
479433004517	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
479433004518	quinolinate synthetase; Provisional; Region: PRK09375
479433004519	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433004520	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
479433004521	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
479433004522	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
479433004523	substrate binding site [chemical binding]; other site
479433004524	ATP binding site [chemical binding]; other site
479433004525	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
479433004526	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
479433004527	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433004528	catalytic residue [active]
479433004529	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
479433004530	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
479433004531	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
479433004532	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
479433004533	D-pathway; other site
479433004534	Putative ubiquinol binding site [chemical binding]; other site
479433004535	Low-spin heme (heme b) binding site [chemical binding]; other site
479433004536	Putative water exit pathway; other site
479433004537	Binuclear center (heme o3/CuB) [ion binding]; other site
479433004538	K-pathway; other site
479433004539	Putative proton exit pathway; other site
479433004540	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
479433004541	LabA_like proteins; Region: LabA_like; cd06167
479433004542	putative metal binding site [ion binding]; other site
479433004543	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
479433004544	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
479433004545	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
479433004546	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
479433004547	putative active site [active]
479433004548	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
479433004549	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
479433004550	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
479433004551	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
479433004552	active site
479433004553	phosphorylation site [posttranslational modification]
479433004554	intermolecular recognition site; other site
479433004555	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
479433004556	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
479433004557	Subunit I/III interface [polypeptide binding]; other site
479433004558	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
479433004559	Cytochrome c; Region: Cytochrom_C; pfam00034
479433004560	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
479433004561	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
479433004562	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
479433004563	iron-sulfur cluster [ion binding]; other site
479433004564	[2Fe-2S] cluster binding site [ion binding]; other site
479433004565	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
479433004566	interchain domain interface [polypeptide binding]; other site
479433004567	intrachain domain interface; other site
479433004568	heme bL binding site [chemical binding]; other site
479433004569	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
479433004570	heme bH binding site [chemical binding]; other site
479433004571	Qo binding site; other site
479433004572	helicase 45; Provisional; Region: PTZ00424
479433004573	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
479433004574	ATP binding site [chemical binding]; other site
479433004575	Mg++ binding site [ion binding]; other site
479433004576	motif III; other site
479433004577	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
479433004578	nucleotide binding region [chemical binding]; other site
479433004579	ATP-binding site [chemical binding]; other site
479433004580	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
479433004581	active site
479433004582	catalytic site [active]
479433004583	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
479433004584	fumarylacetoacetase; Region: PLN02856
479433004585	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
479433004586	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
479433004587	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
479433004588	Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943
479433004589	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
479433004590	Protein tyrosine phosphatase, catalytic domain motif; Region: PTPc_motif; smart00404
479433004591	active site
479433004592	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
479433004593	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
479433004594	active site
479433004595	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
479433004596	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433004597	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433004598	putative substrate translocation pore; other site
479433004599	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
479433004600	active site
479433004601	oligomerization interface [polypeptide binding]; other site
479433004602	metal binding site [ion binding]; metal-binding site
479433004603	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433004604	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433004605	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433004606	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433004607	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433004608	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433004609	NADH(P)-binding; Region: NAD_binding_10; pfam13460
479433004610	NAD(P) binding site [chemical binding]; other site
479433004611	active site
479433004612	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
479433004613	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
479433004614	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
479433004615	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
479433004616	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
479433004617	Possible enoyl reductase; Region: MDR_enoyl_red; cd08244
479433004618	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433004619	putative NAD(P) binding site [chemical binding]; other site
479433004620	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
479433004621	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
479433004622	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433004623	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433004624	DNA binding residues [nucleotide binding]
479433004625	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
479433004626	nudix motif; other site
479433004627	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
479433004628	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
479433004629	metal binding triad; other site
479433004630	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
479433004631	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
479433004632	metal binding triad; other site
479433004633	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
479433004634	Beta-lactamase; Region: Beta-lactamase; pfam00144
479433004635	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
479433004636	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433004637	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
479433004638	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
479433004639	active site
479433004640	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
479433004641	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
479433004642	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
479433004643	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
479433004644	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
479433004645	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
479433004646	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
479433004647	active site
479433004648	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
479433004649	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433004650	Walker A/P-loop; other site
479433004651	ATP binding site [chemical binding]; other site
479433004652	Q-loop/lid; other site
479433004653	ABC transporter signature motif; other site
479433004654	Walker B; other site
479433004655	D-loop; other site
479433004656	H-loop/switch region; other site
479433004657	TOBE domain; Region: TOBE_2; pfam08402
479433004658	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433004659	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433004660	dimer interface [polypeptide binding]; other site
479433004661	conserved gate region; other site
479433004662	putative PBP binding loops; other site
479433004663	ABC-ATPase subunit interface; other site
479433004664	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433004665	dimer interface [polypeptide binding]; other site
479433004666	conserved gate region; other site
479433004667	putative PBP binding loops; other site
479433004668	ABC-ATPase subunit interface; other site
479433004669	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
479433004670	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433004671	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
479433004672	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433004673	DNA-binding site [nucleotide binding]; DNA binding site
479433004674	UTRA domain; Region: UTRA; pfam07702
479433004675	KduI/IolB family; Region: KduI; pfam04962
479433004676	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
479433004677	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
479433004678	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
479433004679	RibD C-terminal domain; Region: RibD_C; cl17279
479433004680	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
479433004681	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
479433004682	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
479433004683	active site
479433004684	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
479433004685	choline dehydrogenase; Validated; Region: PRK02106
479433004686	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
479433004687	Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575
479433004688	active site
479433004689	dimer interface [polypeptide binding]; other site
479433004690	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433004691	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433004692	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
479433004693	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
479433004694	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433004695	Walker A motif; other site
479433004696	ATP binding site [chemical binding]; other site
479433004697	Walker B motif; other site
479433004698	arginine finger; other site
479433004699	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
479433004700	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
479433004701	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
479433004702	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
479433004703	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
479433004704	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
479433004705	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
479433004706	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
479433004707	active site
479433004708	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
479433004709	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
479433004710	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
479433004711	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
479433004712	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
479433004713	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
479433004714	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
479433004715	FAD binding pocket [chemical binding]; other site
479433004716	FAD binding motif [chemical binding]; other site
479433004717	phosphate binding motif [ion binding]; other site
479433004718	beta-alpha-beta structure motif; other site
479433004719	NAD(p) ribose binding residues [chemical binding]; other site
479433004720	NAD binding pocket [chemical binding]; other site
479433004721	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
479433004722	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
479433004723	catalytic loop [active]
479433004724	iron binding site [ion binding]; other site
479433004725	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
479433004726	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
479433004727	heme-binding site [chemical binding]; other site
479433004728	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
479433004729	FAD binding pocket [chemical binding]; other site
479433004730	FAD binding motif [chemical binding]; other site
479433004731	phosphate binding motif [ion binding]; other site
479433004732	beta-alpha-beta structure motif; other site
479433004733	NAD binding pocket [chemical binding]; other site
479433004734	GTPase RsgA; Reviewed; Region: PRK01889
479433004735	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
479433004736	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
479433004737	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433004738	active site
479433004739	Predicted acetyltransferase [General function prediction only]; Region: COG2388
479433004740	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
479433004741	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
479433004742	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
479433004743	substrate binding site [chemical binding]; other site
479433004744	ATP binding site [chemical binding]; other site
479433004745	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
479433004746	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433004747	Walker A/P-loop; other site
479433004748	ATP binding site [chemical binding]; other site
479433004749	Q-loop/lid; other site
479433004750	ABC transporter signature motif; other site
479433004751	Walker B; other site
479433004752	D-loop; other site
479433004753	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
479433004754	SPFH domain / Band 7 family; Region: Band_7; pfam01145
479433004755	Transcriptional regulators [Transcription]; Region: FadR; COG2186
479433004756	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433004757	DNA-binding site [nucleotide binding]; DNA binding site
479433004758	FCD domain; Region: FCD; pfam07729
479433004759	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
479433004760	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
479433004761	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433004762	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
479433004763	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433004764	DNA binding residues [nucleotide binding]
479433004765	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
479433004766	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433004767	ATP binding site [chemical binding]; other site
479433004768	Mg2+ binding site [ion binding]; other site
479433004769	G-X-G motif; other site
479433004770	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
479433004771	anchoring element; other site
479433004772	dimer interface [polypeptide binding]; other site
479433004773	ATP binding site [chemical binding]; other site
479433004774	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
479433004775	active site
479433004776	metal binding site [ion binding]; metal-binding site
479433004777	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
479433004778	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
479433004779	FOG: WD40 repeat [General function prediction only]; Region: COG2319
479433004780	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
479433004781	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
479433004782	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
479433004783	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
479433004784	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
479433004785	Walker A/P-loop; other site
479433004786	ATP binding site [chemical binding]; other site
479433004787	Q-loop/lid; other site
479433004788	ABC transporter signature motif; other site
479433004789	Walker B; other site
479433004790	D-loop; other site
479433004791	H-loop/switch region; other site
479433004792	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
479433004793	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
479433004794	Walker A/P-loop; other site
479433004795	ATP binding site [chemical binding]; other site
479433004796	Q-loop/lid; other site
479433004797	ABC transporter signature motif; other site
479433004798	Walker B; other site
479433004799	D-loop; other site
479433004800	H-loop/switch region; other site
479433004801	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433004802	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433004803	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
479433004804	dimerization interface [polypeptide binding]; other site
479433004805	SnoaL-like domain; Region: SnoaL_4; pfam13577
479433004806	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
479433004807	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
479433004808	CAP-like domain; other site
479433004809	active site
479433004810	primary dimer interface [polypeptide binding]; other site
479433004811	PglZ domain; Region: PglZ; pfam08665
479433004812	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
479433004813	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
479433004814	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
479433004815	active site residue [active]
479433004816	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
479433004817	active site residue [active]
479433004818	Iron permease FTR1 family; Region: FTR1; cl00475
479433004819	Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822
479433004820	Imelysin; Region: Peptidase_M75; pfam09375
479433004821	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
479433004822	hypothetical protein; Provisional; Region: PRK01346
479433004823	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
479433004824	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433004825	Coenzyme A binding pocket [chemical binding]; other site
479433004826	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
479433004827	Predicted membrane protein [Function unknown]; Region: COG2860
479433004828	UPF0126 domain; Region: UPF0126; pfam03458
479433004829	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433004830	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433004831	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433004832	DNA binding residues [nucleotide binding]
479433004833	aconitate hydratase; Validated; Region: PRK09277
479433004834	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
479433004835	substrate binding site [chemical binding]; other site
479433004836	ligand binding site [chemical binding]; other site
479433004837	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
479433004838	substrate binding site [chemical binding]; other site
479433004839	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
479433004840	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
479433004841	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
479433004842	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
479433004843	TPP-binding site; other site
479433004844	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
479433004845	PYR/PP interface [polypeptide binding]; other site
479433004846	dimer interface [polypeptide binding]; other site
479433004847	TPP binding site [chemical binding]; other site
479433004848	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
479433004849	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
479433004850	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
479433004851	Domain of unknown function (DUF427); Region: DUF427; cl00998
479433004852	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
479433004853	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
479433004854	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
479433004855	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
479433004856	metal-binding site [ion binding]
479433004857	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
479433004858	active site
479433004859	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
479433004860	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
479433004861	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
479433004862	Peptidase C26; Region: Peptidase_C26; pfam07722
479433004863	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
479433004864	catalytic triad [active]
479433004865	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
479433004866	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
479433004867	NAD(P) binding site [chemical binding]; other site
479433004868	catalytic residues [active]
479433004869	short chain dehydrogenase; Provisional; Region: PRK06138
479433004870	classical (c) SDRs; Region: SDR_c; cd05233
479433004871	NAD(P) binding site [chemical binding]; other site
479433004872	active site
479433004873	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
479433004874	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
479433004875	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433004876	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433004877	Walker A/P-loop; other site
479433004878	ATP binding site [chemical binding]; other site
479433004879	Q-loop/lid; other site
479433004880	ABC transporter signature motif; other site
479433004881	Walker B; other site
479433004882	D-loop; other site
479433004883	H-loop/switch region; other site
479433004884	ABC-2 type transporter; Region: ABC2_membrane; cl17235
479433004885	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
479433004886	ABC-2 type transporter; Region: ABC2_membrane; cl17235
479433004887	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
479433004888	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433004889	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433004890	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433004891	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938
479433004892	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
479433004893	inhibitor-cofactor binding pocket; inhibition site
479433004894	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433004895	catalytic residue [active]
479433004896	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
479433004897	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433004898	catalytic residue [active]
479433004899	IucA / IucC family; Region: IucA_IucC; pfam04183
479433004900	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
479433004901	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
479433004902	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
479433004903	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
479433004904	Coenzyme A binding pocket [chemical binding]; other site
479433004905	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433004906	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
479433004907	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
479433004908	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
479433004909	IucA / IucC family; Region: IucA_IucC; pfam04183
479433004910	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
479433004911	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
479433004912	DEAD/DEAH box helicase; Region: DEAD; pfam00270
479433004913	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
479433004914	ATP binding site [chemical binding]; other site
479433004915	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
479433004916	LexA repressor; Validated; Region: PRK00215
479433004917	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
479433004918	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
479433004919	Catalytic site [active]
479433004920	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
479433004921	ATP cone domain; Region: ATP-cone; pfam03477
479433004922	vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556
479433004923	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
479433004924	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
479433004925	active site
479433004926	dimer interface [polypeptide binding]; other site
479433004927	effector binding site; other site
479433004928	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
479433004929	TSCPD domain; Region: TSCPD; pfam12637
479433004930	Fic family protein [Function unknown]; Region: COG3177
479433004931	Fic/DOC family; Region: Fic; pfam02661
479433004932	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
479433004933	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
479433004934	putative active site [active]
479433004935	metal binding site [ion binding]; metal-binding site
479433004936	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
479433004937	dimerization interface [polypeptide binding]; other site
479433004938	active site
479433004939	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433004940	MarR family; Region: MarR; pfam01047
479433004941	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433004942	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433004943	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433004944	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
479433004945	NAD(P) binding site [chemical binding]; other site
479433004946	active site
479433004947	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
479433004948	FAD binding domain; Region: FAD_binding_4; pfam01565
479433004949	Predicted transcriptional regulators [Transcription]; Region: COG1733
479433004950	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
479433004951	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433004952	NAD(P) binding site [chemical binding]; other site
479433004953	active site
479433004954	NADH(P)-binding; Region: NAD_binding_10; pfam13460
479433004955	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
479433004956	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
479433004957	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433004958	TIGR01777 family protein; Region: yfcH
479433004959	NAD(P) binding site [chemical binding]; other site
479433004960	active site
479433004961	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
479433004962	E3 interaction surface; other site
479433004963	lipoyl attachment site [posttranslational modification]; other site
479433004964	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
479433004965	E3 interaction surface; other site
479433004966	lipoyl attachment site [posttranslational modification]; other site
479433004967	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
479433004968	e3 binding domain; Region: E3_binding; pfam02817
479433004969	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
479433004970	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
479433004971	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
479433004972	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
479433004973	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
479433004974	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
479433004975	multifunctional aminopeptidase A; Provisional; Region: PRK00913
479433004976	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
479433004977	interface (dimer of trimers) [polypeptide binding]; other site
479433004978	Substrate-binding/catalytic site; other site
479433004979	Zn-binding sites [ion binding]; other site
479433004980	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
479433004981	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
479433004982	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
479433004983	active site
479433004984	catalytic residues [active]
479433004985	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
479433004986	cobalamin synthase; Reviewed; Region: cobS; PRK00235
479433004987	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
479433004988	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
479433004989	active site pocket [active]
479433004990	putative dimer interface [polypeptide binding]; other site
479433004991	putative cataytic base [active]
479433004992	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283
479433004993	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
479433004994	nudix motif; other site
479433004995	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722
479433004996	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
479433004997	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
479433004998	FtsH Extracellular; Region: FtsH_ext; pfam06480
479433004999	Uncharacterized conserved protein [Function unknown]; Region: COG2966
479433005000	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
479433005001	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
479433005002	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
479433005003	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
479433005004	TrkA-C domain; Region: TrkA_C; pfam02080
479433005005	TrkA-C domain; Region: TrkA_C; pfam02080
479433005006	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
479433005007	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
479433005008	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433005009	substrate binding site [chemical binding]; other site
479433005010	activation loop (A-loop); other site
479433005011	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
479433005012	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
479433005013	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433005014	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433005015	active site
479433005016	catalytic tetrad [active]
479433005017	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
479433005018	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
479433005019	Peptidase family M48; Region: Peptidase_M48; cl12018
479433005020	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
479433005021	putative catalytic site [active]
479433005022	putative metal binding site [ion binding]; other site
479433005023	putative phosphate binding site [ion binding]; other site
479433005024	Predicted permeases [General function prediction only]; Region: COG0679
479433005025	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
479433005026	membrane protein FdrA; Validated; Region: PRK06091
479433005027	membrane protein FdrA; Validated; Region: PRK06091
479433005028	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
479433005029	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
479433005030	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
479433005031	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
479433005032	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
479433005033	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
479433005034	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
479433005035	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
479433005036	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
479433005037	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
479433005038	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
479433005039	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
479433005040	putative hydrophobic ligand binding site [chemical binding]; other site
479433005041	Predicted amidohydrolase [General function prediction only]; Region: COG0388
479433005042	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
479433005043	active site
479433005044	catalytic triad [active]
479433005045	dimer interface [polypeptide binding]; other site
479433005046	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
479433005047	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
479433005048	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
479433005049	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
479433005050	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
479433005051	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
479433005052	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
479433005053	putative substrate binding site [chemical binding]; other site
479433005054	nucleotide binding site [chemical binding]; other site
479433005055	nucleotide binding site [chemical binding]; other site
479433005056	homodimer interface [polypeptide binding]; other site
479433005057	Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663
479433005058	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
479433005059	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
479433005060	XdhC Rossmann domain; Region: XdhC_C; pfam13478
479433005061	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
479433005062	metal-binding site
479433005063	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
479433005064	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
479433005065	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
479433005066	Peptidase family M48; Region: Peptidase_M48; cl12018
479433005067	Predicted membrane protein [Function unknown]; Region: COG3462
479433005068	Short C-terminal domain; Region: SHOCT; pfam09851
479433005069	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
479433005070	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
479433005071	FtsX-like permease family; Region: FtsX; pfam02687
479433005072	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
479433005073	FtsX-like permease family; Region: FtsX; pfam02687
479433005074	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
479433005075	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
479433005076	PemK-like protein; Region: PemK; pfam02452
479433005077	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
479433005078	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
479433005079	N-acetyl-D-glucosamine binding site [chemical binding]; other site
479433005080	catalytic residue [active]
479433005081	AAA ATPase domain; Region: AAA_16; pfam13191
479433005082	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433005083	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433005084	DNA binding residues [nucleotide binding]
479433005085	dimerization interface [polypeptide binding]; other site
479433005086	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
479433005087	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
479433005088	catalytic residues [active]
479433005089	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433005090	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
479433005091	Walker A/P-loop; other site
479433005092	ATP binding site [chemical binding]; other site
479433005093	Q-loop/lid; other site
479433005094	ABC transporter signature motif; other site
479433005095	Walker B; other site
479433005096	D-loop; other site
479433005097	H-loop/switch region; other site
479433005098	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433005099	Histidine kinase; Region: HisKA_3; pfam07730
479433005100	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433005101	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433005102	active site
479433005103	phosphorylation site [posttranslational modification]
479433005104	intermolecular recognition site; other site
479433005105	dimerization interface [polypeptide binding]; other site
479433005106	dimerization interface [polypeptide binding]; other site
479433005107	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
479433005108	DNA binding residues [nucleotide binding]
479433005109	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722
479433005110	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
479433005111	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
479433005112	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
479433005113	active site
479433005114	catalytic triad [active]
479433005115	calcium binding site [ion binding]; other site
479433005116	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
479433005117	DNA-binding site [nucleotide binding]; DNA binding site
479433005118	RNA-binding motif; other site
479433005119	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
479433005120	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
479433005121	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
479433005122	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
479433005123	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433005124	Cytochrome P450; Region: p450; cl12078
479433005125	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433005126	dimerization interface [polypeptide binding]; other site
479433005127	putative DNA binding site [nucleotide binding]; other site
479433005128	putative Zn2+ binding site [ion binding]; other site
479433005129	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
479433005130	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
479433005131	nucleophilic elbow; other site
479433005132	catalytic triad; other site
479433005133	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
479433005134	catalytic residues [active]
479433005135	catalytic nucleophile [active]
479433005136	Recombinase; Region: Recombinase; pfam07508
479433005137	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
479433005138	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
479433005139	CGNR zinc finger; Region: zf-CGNR; pfam11706
479433005140	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
479433005141	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
479433005142	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
479433005143	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
479433005144	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
479433005145	Walker A/P-loop; other site
479433005146	ATP binding site [chemical binding]; other site
479433005147	Q-loop/lid; other site
479433005148	ABC transporter signature motif; other site
479433005149	Walker B; other site
479433005150	D-loop; other site
479433005151	H-loop/switch region; other site
479433005152	FtsX-like permease family; Region: FtsX; pfam02687
479433005153	Putative sensor; Region: Sensor; pfam13796
479433005154	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433005155	Histidine kinase; Region: HisKA_3; pfam07730
479433005156	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433005157	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433005158	active site
479433005159	phosphorylation site [posttranslational modification]
479433005160	intermolecular recognition site; other site
479433005161	dimerization interface [polypeptide binding]; other site
479433005162	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433005163	DNA binding residues [nucleotide binding]
479433005164	dimerization interface [polypeptide binding]; other site
479433005165	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
479433005166	anti sigma factor interaction site; other site
479433005167	regulatory phosphorylation site [posttranslational modification]; other site
479433005168	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433005169	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433005170	ATP binding site [chemical binding]; other site
479433005171	Mg2+ binding site [ion binding]; other site
479433005172	G-X-G motif; other site
479433005173	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
479433005174	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433005175	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
479433005176	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433005177	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
479433005178	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433005179	DNA binding residues [nucleotide binding]
479433005180	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
479433005181	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
479433005182	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
479433005183	Response regulator receiver domain; Region: Response_reg; pfam00072
479433005184	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433005185	active site
479433005186	phosphorylation site [posttranslational modification]
479433005187	intermolecular recognition site; other site
479433005188	dimerization interface [polypeptide binding]; other site
479433005189	Protein kinase domain; Region: Pkinase; pfam00069
479433005190	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433005191	active site
479433005192	ATP binding site [chemical binding]; other site
479433005193	substrate binding site [chemical binding]; other site
479433005194	activation loop (A-loop); other site
479433005195	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433005196	MarR family; Region: MarR_2; pfam12802
479433005197	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
479433005198	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
479433005199	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
479433005200	generic binding surface II; other site
479433005201	generic binding surface I; other site
479433005202	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
479433005203	putative catalytic site [active]
479433005204	putative metal binding site [ion binding]; other site
479433005205	putative phosphate binding site [ion binding]; other site
479433005206	ribonuclease; Region: Ribonuclease; pfam00545
479433005207	CHAD domain; Region: CHAD; pfam05235
479433005208	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
479433005209	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
479433005210	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
479433005211	PYR/PP interface [polypeptide binding]; other site
479433005212	dimer interface [polypeptide binding]; other site
479433005213	TPP binding site [chemical binding]; other site
479433005214	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
479433005215	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
479433005216	TPP-binding site [chemical binding]; other site
479433005217	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433005218	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433005219	dimer interface [polypeptide binding]; other site
479433005220	conserved gate region; other site
479433005221	putative PBP binding loops; other site
479433005222	ABC-ATPase subunit interface; other site
479433005223	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
479433005224	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
479433005225	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433005226	putative PBP binding loops; other site
479433005227	dimer interface [polypeptide binding]; other site
479433005228	ABC-ATPase subunit interface; other site
479433005229	carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851
479433005230	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433005231	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
479433005232	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433005233	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433005234	DNA binding site [nucleotide binding]
479433005235	domain linker motif; other site
479433005236	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433005237	ligand binding site [chemical binding]; other site
479433005238	dimerization interface [polypeptide binding]; other site
479433005239	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
479433005240	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
479433005241	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433005242	homodimer interface [polypeptide binding]; other site
479433005243	catalytic residue [active]
479433005244	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
479433005245	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433005246	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433005247	active site
479433005248	phosphorylation site [posttranslational modification]
479433005249	intermolecular recognition site; other site
479433005250	dimerization interface [polypeptide binding]; other site
479433005251	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433005252	DNA binding residues [nucleotide binding]
479433005253	dimerization interface [polypeptide binding]; other site
479433005254	Histidine kinase; Region: HisKA_3; pfam07730
479433005255	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433005256	MMPL family; Region: MMPL; pfam03176
479433005257	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
479433005258	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
479433005259	active site
479433005260	motif I; other site
479433005261	motif II; other site
479433005262	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
479433005263	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
479433005264	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
479433005265	metal binding site [ion binding]; metal-binding site
479433005266	substrate binding pocket [chemical binding]; other site
479433005267	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433005268	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433005269	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
479433005270	short chain dehydrogenase; Provisional; Region: PRK06197
479433005271	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433005272	NAD(P) binding site [chemical binding]; other site
479433005273	active site
479433005274	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
479433005275	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
479433005276	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
479433005277	active site
479433005278	trimer interface [polypeptide binding]; other site
479433005279	allosteric site; other site
479433005280	active site lid [active]
479433005281	hexamer (dimer of trimers) interface [polypeptide binding]; other site
479433005282	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
479433005283	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433005284	NAD(P) binding site [chemical binding]; other site
479433005285	active site
479433005286	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433005287	MarR family; Region: MarR_2; pfam12802
479433005288	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
479433005289	active site
479433005290	catalytic triad [active]
479433005291	calcium binding site [ion binding]; other site
479433005292	Peptidase family M48; Region: Peptidase_M48; cl12018
479433005293	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
479433005294	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433005295	salt bridge; other site
479433005296	non-specific DNA binding site [nucleotide binding]; other site
479433005297	sequence-specific DNA binding site [nucleotide binding]; other site
479433005298	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
479433005299	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
479433005300	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433005301	MarR family; Region: MarR_2; cl17246
479433005302	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433005303	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433005304	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433005305	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
479433005306	dimerization interface [polypeptide binding]; other site
479433005307	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
479433005308	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
479433005309	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
479433005310	sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678
479433005311	FAD binding domain; Region: FAD_binding_4; pfam01565
479433005312	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
479433005313	FOG: CBS domain [General function prediction only]; Region: COG0517
479433005314	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
479433005315	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433005316	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
479433005317	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
479433005318	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
479433005319	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
479433005320	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433005321	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433005322	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433005323	binding surface
479433005324	TPR motif; other site
479433005325	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433005326	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433005327	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433005328	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433005329	binding surface
479433005330	TPR motif; other site
479433005331	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433005332	non-specific DNA binding site [nucleotide binding]; other site
479433005333	salt bridge; other site
479433005334	sequence-specific DNA binding site [nucleotide binding]; other site
479433005335	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433005336	non-specific DNA binding site [nucleotide binding]; other site
479433005337	salt bridge; other site
479433005338	sequence-specific DNA binding site [nucleotide binding]; other site
479433005339	Domain of unknown function (DUF397); Region: DUF397; pfam04149
479433005340	AAA ATPase domain; Region: AAA_16; pfam13191
479433005341	NB-ARC domain; Region: NB-ARC; pfam00931
479433005342	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433005343	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433005344	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
479433005345	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433005346	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433005347	active site
479433005348	ATP binding site [chemical binding]; other site
479433005349	substrate binding site [chemical binding]; other site
479433005350	activation loop (A-loop); other site
479433005351	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
479433005352	phosphopeptide binding site; other site
479433005353	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
479433005354	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
479433005355	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433005356	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433005357	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433005358	DNA binding residues [nucleotide binding]
479433005359	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
479433005360	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
479433005361	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
479433005362	DNA binding residues [nucleotide binding]
479433005363	drug binding residues [chemical binding]; other site
479433005364	dimer interface [polypeptide binding]; other site
479433005365	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
479433005366	putative metal binding site [ion binding]; other site
479433005367	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
479433005368	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
479433005369	active site
479433005370	catalytic site [active]
479433005371	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433005372	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433005373	putative sugar binding sites [chemical binding]; other site
479433005374	Q-X-W motif; other site
479433005375	Ricin-type beta-trefoil; Region: RICIN; smart00458
479433005376	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433005377	putative sugar binding sites [chemical binding]; other site
479433005378	Q-X-W motif; other site
479433005379	succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407
479433005380	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101
479433005381	NAD(P) binding site [chemical binding]; other site
479433005382	catalytic residues [active]
479433005383	Predicted transcriptional regulators [Transcription]; Region: COG1725
479433005384	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433005385	DNA-binding site [nucleotide binding]; DNA binding site
479433005386	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
479433005387	active site
479433005388	catalytic triad [active]
479433005389	calcium binding site [ion binding]; other site
479433005390	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
479433005391	PKC phosphorylation site [posttranslational modification]; other site
479433005392	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
479433005393	PKC phosphorylation site [posttranslational modification]; other site
479433005394	Phosphoesterase family; Region: Phosphoesterase; pfam04185
479433005395	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433005396	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
479433005397	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
479433005398	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
479433005399	G1 box; other site
479433005400	GTP/Mg2+ binding site [chemical binding]; other site
479433005401	G2 box; other site
479433005402	Switch I region; other site
479433005403	G3 box; other site
479433005404	Switch II region; other site
479433005405	G4 box; other site
479433005406	G5 box; other site
479433005407	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346
479433005408	benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184
479433005409	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
479433005410	substrate binding site [chemical binding]; other site
479433005411	oxyanion hole (OAH) forming residues; other site
479433005412	trimer interface [polypeptide binding]; other site
479433005413	PaaX-like protein; Region: PaaX; pfam07848
479433005414	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
479433005415	amino acid transporter; Region: 2A0306; TIGR00909
479433005416	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
479433005417	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433005418	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433005419	DNA binding site [nucleotide binding]
479433005420	domain linker motif; other site
479433005421	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433005422	dimerization interface [polypeptide binding]; other site
479433005423	ligand binding site [chemical binding]; other site
479433005424	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433005425	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
479433005426	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
479433005427	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433005428	dimer interface [polypeptide binding]; other site
479433005429	conserved gate region; other site
479433005430	putative PBP binding loops; other site
479433005431	ABC-ATPase subunit interface; other site
479433005432	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433005433	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433005434	dimer interface [polypeptide binding]; other site
479433005435	conserved gate region; other site
479433005436	putative PBP binding loops; other site
479433005437	ABC-ATPase subunit interface; other site
479433005438	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433005439	putative DNA binding site [nucleotide binding]; other site
479433005440	putative Zn2+ binding site [ion binding]; other site
479433005441	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433005442	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
479433005443	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
479433005444	active site
479433005445	metal binding site [ion binding]; metal-binding site
479433005446	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433005447	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433005448	dimer interface [polypeptide binding]; other site
479433005449	phosphorylation site [posttranslational modification]
479433005450	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433005451	ATP binding site [chemical binding]; other site
479433005452	Mg2+ binding site [ion binding]; other site
479433005453	G-X-G motif; other site
479433005454	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433005455	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433005456	active site
479433005457	phosphorylation site [posttranslational modification]
479433005458	intermolecular recognition site; other site
479433005459	dimerization interface [polypeptide binding]; other site
479433005460	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433005461	DNA binding site [nucleotide binding]
479433005462	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
479433005463	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
479433005464	ssDNA binding site; other site
479433005465	generic binding surface II; other site
479433005466	Protein of unknown function (DUF2528); Region: DUF2528; pfam10800
479433005467	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433005468	putative DNA binding site [nucleotide binding]; other site
479433005469	putative Zn2+ binding site [ion binding]; other site
479433005470	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433005471	S-adenosylmethionine binding site [chemical binding]; other site
479433005472	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
479433005473	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
479433005474	catalytic residues [active]
479433005475	alpha-glucosidase; Provisional; Region: PRK10137
479433005476	Trehalase; Region: Trehalase; cl17346
479433005477	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
479433005478	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
479433005479	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
479433005480	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
479433005481	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433005482	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433005483	dimer interface [polypeptide binding]; other site
479433005484	conserved gate region; other site
479433005485	putative PBP binding loops; other site
479433005486	ABC-ATPase subunit interface; other site
479433005487	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
479433005488	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433005489	dimer interface [polypeptide binding]; other site
479433005490	conserved gate region; other site
479433005491	putative PBP binding loops; other site
479433005492	ABC-ATPase subunit interface; other site
479433005493	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433005494	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433005495	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
479433005496	glycine dehydrogenase subunit 1; Validated; Region: PRK00451
479433005497	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433005498	catalytic residue [active]
479433005499	glycine dehydrogenase subunit 2; Validated; Region: PRK04366
479433005500	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433005501	catalytic residue [active]
479433005502	Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199
479433005503	ATP-NAD kinase; Region: NAD_kinase; pfam01513
479433005504	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
479433005505	classical (c) SDRs; Region: SDR_c; cd05233
479433005506	NAD(P) binding site [chemical binding]; other site
479433005507	active site
479433005508	Transcriptional regulators [Transcription]; Region: GntR; COG1802
479433005509	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433005510	DNA-binding site [nucleotide binding]; DNA binding site
479433005511	FCD domain; Region: FCD; pfam07729
479433005512	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
479433005513	sequence-specific DNA binding site [nucleotide binding]; other site
479433005514	salt bridge; other site
479433005515	Clp protease; Region: CLP_protease; pfam00574
479433005516	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
479433005517	oligomer interface [polypeptide binding]; other site
479433005518	active site residues [active]
479433005519	Clp protease; Region: CLP_protease; pfam00574
479433005520	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
479433005521	oligomer interface [polypeptide binding]; other site
479433005522	active site residues [active]
479433005523	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
479433005524	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
479433005525	intersubunit interface [polypeptide binding]; other site
479433005526	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
479433005527	dimer interface [polypeptide binding]; other site
479433005528	putative radical transfer pathway; other site
479433005529	diiron center [ion binding]; other site
479433005530	tyrosyl radical; other site
479433005531	ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506
479433005532	Class I ribonucleotide reductase; Region: RNR_I; cd01679
479433005533	active site
479433005534	dimer interface [polypeptide binding]; other site
479433005535	catalytic residues [active]
479433005536	effector binding site; other site
479433005537	R2 peptide binding site; other site
479433005538	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
479433005539	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433005540	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433005541	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
479433005542	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433005543	NAD(P) binding site [chemical binding]; other site
479433005544	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433005545	NADH(P)-binding; Region: NAD_binding_10; pfam13460
479433005546	NAD(P) binding site [chemical binding]; other site
479433005547	active site
479433005548	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433005549	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433005550	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
479433005551	active site
479433005552	catalytic triad [active]
479433005553	oxyanion hole [active]
479433005554	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
479433005555	Helix-turn-helix domain; Region: HTH_31; pfam13560
479433005556	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
479433005557	Ricin-type beta-trefoil; Region: RICIN; smart00458
479433005558	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433005559	putative sugar binding sites [chemical binding]; other site
479433005560	Q-X-W motif; other site
479433005561	YceG-like family; Region: YceG; pfam02618
479433005562	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
479433005563	dimerization interface [polypeptide binding]; other site
479433005564	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
479433005565	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433005566	MarR family; Region: MarR; pfam01047
479433005567	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433005568	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433005569	putative substrate translocation pore; other site
479433005570	Copper resistance protein D; Region: CopD; pfam05425
479433005571	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433005572	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433005573	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433005574	DNA binding residues [nucleotide binding]
479433005575	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433005576	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
479433005577	Walker A/P-loop; other site
479433005578	ATP binding site [chemical binding]; other site
479433005579	Q-loop/lid; other site
479433005580	ABC transporter signature motif; other site
479433005581	Walker B; other site
479433005582	D-loop; other site
479433005583	H-loop/switch region; other site
479433005584	ABC-2 type transporter; Region: ABC2_membrane; cl17235
479433005585	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
479433005586	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
479433005587	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433005588	Predicted ATPase [General function prediction only]; Region: COG3903
479433005589	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433005590	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433005591	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
479433005592	putative substrate binding pocket [chemical binding]; other site
479433005593	putative dimerization interface [polypeptide binding]; other site
479433005594	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
479433005595	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
479433005596	active site
479433005597	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
479433005598	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
479433005599	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433005600	MarR family; Region: MarR_2; cl17246
479433005601	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
479433005602	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
479433005603	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
479433005604	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
479433005605	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
479433005606	Ligand binding site; other site
479433005607	Putative Catalytic site; other site
479433005608	DXD motif; other site
479433005609	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433005610	binding surface
479433005611	TPR motif; other site
479433005612	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433005613	binding surface
479433005614	TPR motif; other site
479433005615	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433005616	binding surface
479433005617	TPR motif; other site
479433005618	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
479433005619	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433005620	ATP binding site [chemical binding]; other site
479433005621	Walker B motif; other site
479433005622	arginine finger; other site
479433005623	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
479433005624	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433005625	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
479433005626	putative dimerization interface [polypeptide binding]; other site
479433005627	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433005628	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433005629	active site
479433005630	catalytic tetrad [active]
479433005631	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
479433005632	RHS Repeat; Region: RHS_repeat; cl11982
479433005633	RHS Repeat; Region: RHS_repeat; pfam05593
479433005634	RHS Repeat; Region: RHS_repeat; pfam05593
479433005635	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
479433005636	RHS Repeat; Region: RHS_repeat; cl11982
479433005637	RHS Repeat; Region: RHS_repeat; pfam05593
479433005638	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
479433005639	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433005640	Coenzyme A binding pocket [chemical binding]; other site
479433005641	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433005642	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
479433005643	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
479433005644	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
479433005645	FAD binding domain; Region: FAD_binding_2; pfam00890
479433005646	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
479433005647	rRNA binding site [nucleotide binding]; other site
479433005648	predicted 30S ribosome binding site; other site
479433005649	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433005650	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433005651	AAA ATPase domain; Region: AAA_16; pfam13191
479433005652	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433005653	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433005654	DNA binding residues [nucleotide binding]
479433005655	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433005656	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433005657	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433005658	DNA binding residues [nucleotide binding]
479433005659	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263
479433005660	L-aspartate oxidase; Provisional; Region: PRK06175
479433005661	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
479433005662	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433005663	NADH(P)-binding; Region: NAD_binding_10; pfam13460
479433005664	NAD(P) binding site [chemical binding]; other site
479433005665	active site
479433005666	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
479433005667	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
479433005668	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
479433005669	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
479433005670	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433005671	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433005672	DNA binding residues [nucleotide binding]
479433005673	Ferritin-like; Region: Ferritin-like; pfam12902
479433005674	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
479433005675	active site
479433005676	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
479433005677	Src homology 2 (SH2) domain; Region: SH2; cl15255
479433005678	phosphotyrosine binding pocket [polypeptide binding]; other site
479433005679	hydrophobic binding pocket [polypeptide binding]; other site
479433005680	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433005681	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433005682	putative substrate translocation pore; other site
479433005683	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
479433005684	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
479433005685	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
479433005686	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
479433005687	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
479433005688	malonyl-CoA binding site [chemical binding]; other site
479433005689	dimer interface [polypeptide binding]; other site
479433005690	active site
479433005691	product binding site; other site
479433005692	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
479433005693	Methyltransferase domain; Region: Methyltransf_23; pfam13489
479433005694	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433005695	S-adenosylmethionine binding site [chemical binding]; other site
479433005696	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
479433005697	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
479433005698	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
479433005699	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433005700	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433005701	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433005702	dimer interface [polypeptide binding]; other site
479433005703	conserved gate region; other site
479433005704	putative PBP binding loops; other site
479433005705	ABC-ATPase subunit interface; other site
479433005706	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433005707	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433005708	dimer interface [polypeptide binding]; other site
479433005709	conserved gate region; other site
479433005710	putative PBP binding loops; other site
479433005711	ABC-ATPase subunit interface; other site
479433005712	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
479433005713	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
479433005714	active site
479433005715	catalytic site [active]
479433005716	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
479433005717	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433005718	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433005719	DNA binding site [nucleotide binding]
479433005720	domain linker motif; other site
479433005721	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292
479433005722	putative dimerization interface [polypeptide binding]; other site
479433005723	putative ligand binding site [chemical binding]; other site
479433005724	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
479433005725	pfkB family carbohydrate kinase; Region: PfkB; pfam00294
479433005726	substrate binding site [chemical binding]; other site
479433005727	ATP binding site [chemical binding]; other site
479433005728	short chain dehydrogenase; Provisional; Region: PRK06180
479433005729	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
479433005730	NADP binding site [chemical binding]; other site
479433005731	active site
479433005732	steroid binding site; other site
479433005733	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433005734	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433005735	DNA binding residues [nucleotide binding]
479433005736	dimerization interface [polypeptide binding]; other site
479433005737	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
479433005738	TrkA-N domain; Region: TrkA_N; pfam02254
479433005739	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
479433005740	TrkA-N domain; Region: TrkA_N; pfam02254
479433005741	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433005742	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
479433005743	active site
479433005744	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433005745	dimer interface [polypeptide binding]; other site
479433005746	conserved gate region; other site
479433005747	putative PBP binding loops; other site
479433005748	ABC-ATPase subunit interface; other site
479433005749	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
479433005750	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433005751	dimer interface [polypeptide binding]; other site
479433005752	conserved gate region; other site
479433005753	putative PBP binding loops; other site
479433005754	ABC-ATPase subunit interface; other site
479433005755	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
479433005756	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433005757	Walker A/P-loop; other site
479433005758	ATP binding site [chemical binding]; other site
479433005759	Q-loop/lid; other site
479433005760	ABC transporter signature motif; other site
479433005761	Walker B; other site
479433005762	D-loop; other site
479433005763	H-loop/switch region; other site
479433005764	TOBE domain; Region: TOBE_2; pfam08402
479433005765	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
479433005766	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
479433005767	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
479433005768	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
479433005769	NAD(P) binding site [chemical binding]; other site
479433005770	catalytic residues [active]
479433005771	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
479433005772	Coenzyme A transferase; Region: CoA_trans; cl17247
479433005773	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
479433005774	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
479433005775	active site
479433005776	citrylCoA binding site [chemical binding]; other site
479433005777	oxalacetate binding site [chemical binding]; other site
479433005778	coenzyme A binding site [chemical binding]; other site
479433005779	catalytic triad [active]
479433005780	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
479433005781	DNA-binding site [nucleotide binding]; DNA binding site
479433005782	RNA-binding motif; other site
479433005783	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
479433005784	nudix motif; other site
479433005785	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
479433005786	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
479433005787	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
479433005788	NAD binding site [chemical binding]; other site
479433005789	catalytic residues [active]
479433005790	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
479433005791	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
479433005792	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433005793	MarR family; Region: MarR_2; pfam12802
479433005794	MarR family; Region: MarR_2; cl17246
479433005795	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433005796	Coenzyme A binding pocket [chemical binding]; other site
479433005797	Protein of unknown function (DUF1847); Region: DUF1847; cl02037
479433005798	Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847
479433005799	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433005800	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433005801	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
479433005802	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
479433005803	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433005804	S-adenosylmethionine binding site [chemical binding]; other site
479433005805	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
479433005806	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
479433005807	Protein of unknown function, DUF608; Region: DUF608; pfam04685
479433005808	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433005809	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433005810	active site
479433005811	ATP binding site [chemical binding]; other site
479433005812	substrate binding site [chemical binding]; other site
479433005813	activation loop (A-loop); other site
479433005814	Cupin domain; Region: Cupin_2; pfam07883
479433005815	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
479433005816	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
479433005817	YCII-related domain; Region: YCII; cl00999
479433005818	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
479433005819	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433005820	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
479433005821	DNA binding residues [nucleotide binding]
479433005822	Methyltransferase domain; Region: Methyltransf_24; pfam13578
479433005823	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433005824	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433005825	active site
479433005826	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433005827	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433005828	active site
479433005829	lipid-transfer protein; Provisional; Region: PRK08256
479433005830	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
479433005831	active site
479433005832	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433005833	putative DNA binding site [nucleotide binding]; other site
479433005834	putative Zn2+ binding site [ion binding]; other site
479433005835	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433005836	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
479433005837	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433005838	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
479433005839	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
479433005840	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433005841	putative PBP binding loops; other site
479433005842	dimer interface [polypeptide binding]; other site
479433005843	ABC-ATPase subunit interface; other site
479433005844	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433005845	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433005846	dimer interface [polypeptide binding]; other site
479433005847	conserved gate region; other site
479433005848	putative PBP binding loops; other site
479433005849	ABC-ATPase subunit interface; other site
479433005850	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
479433005851	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433005852	Walker A/P-loop; other site
479433005853	ATP binding site [chemical binding]; other site
479433005854	Q-loop/lid; other site
479433005855	ABC transporter signature motif; other site
479433005856	Walker B; other site
479433005857	D-loop; other site
479433005858	H-loop/switch region; other site
479433005859	TOBE domain; Region: TOBE_2; pfam08402
479433005860	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
479433005861	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
479433005862	motif II; other site
479433005863	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
479433005864	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
479433005865	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
479433005866	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
479433005867	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
479433005868	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
479433005869	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
479433005870	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
479433005871	substrate binding pocket [chemical binding]; other site
479433005872	membrane-bound complex binding site; other site
479433005873	hinge residues; other site
479433005874	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433005875	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433005876	active site
479433005877	ATP binding site [chemical binding]; other site
479433005878	substrate binding site [chemical binding]; other site
479433005879	activation loop (A-loop); other site
479433005880	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433005881	binding surface
479433005882	TPR motif; other site
479433005883	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
479433005884	Double zinc ribbon; Region: DZR; pfam12773
479433005885	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
479433005886	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
479433005887	metal ion-dependent adhesion site (MIDAS); other site
479433005888	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
479433005889	phosphopeptide binding site; other site
479433005890	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
479433005891	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
479433005892	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
479433005893	Predicted periplasmic protein [Function unknown]; Region: COG3698
479433005894	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
479433005895	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
479433005896	conserved cys residue [active]
479433005897	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433005898	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
479433005899	Isochorismatase family; Region: Isochorismatase; pfam00857
479433005900	catalytic triad [active]
479433005901	conserved cis-peptide bond; other site
479433005902	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433005903	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433005904	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433005905	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433005906	putative PBP binding loops; other site
479433005907	dimer interface [polypeptide binding]; other site
479433005908	ABC-ATPase subunit interface; other site
479433005909	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433005910	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433005911	dimer interface [polypeptide binding]; other site
479433005912	conserved gate region; other site
479433005913	putative PBP binding loops; other site
479433005914	ABC-ATPase subunit interface; other site
479433005915	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
479433005916	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
479433005917	homodimer interface [polypeptide binding]; other site
479433005918	putative substrate binding pocket [chemical binding]; other site
479433005919	diiron center [ion binding]; other site
479433005920	acyl-CoA synthetase; Validated; Region: PRK07798
479433005921	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433005922	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
479433005923	acyl-activating enzyme (AAE) consensus motif; other site
479433005924	acyl-activating enzyme (AAE) consensus motif; other site
479433005925	putative AMP binding site [chemical binding]; other site
479433005926	putative active site [active]
479433005927	putative CoA binding site [chemical binding]; other site
479433005928	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433005929	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
479433005930	active site
479433005931	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433005932	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433005933	active site
479433005934	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
479433005935	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
479433005936	RNA polymerase factor sigma-70; Validated; Region: PRK08241
479433005937	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433005938	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433005939	DNA binding residues [nucleotide binding]
479433005940	SnoaL-like domain; Region: SnoaL_2; pfam12680
479433005941	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433005942	short chain dehydrogenase; Validated; Region: PRK08264
479433005943	NAD(P) binding site [chemical binding]; other site
479433005944	active site
479433005945	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
479433005946	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433005947	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
479433005948	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
479433005949	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
479433005950	iron-sulfur cluster [ion binding]; other site
479433005951	[2Fe-2S] cluster binding site [ion binding]; other site
479433005952	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
479433005953	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
479433005954	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
479433005955	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
479433005956	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433005957	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433005958	active site
479433005959	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
479433005960	Beta-lactamase; Region: Beta-lactamase; pfam00144
479433005961	Protein of unknown function DUF89; Region: DUF89; pfam01937
479433005962	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
479433005963	Predicted flavoprotein [General function prediction only]; Region: COG0431
479433005964	Predicted transcriptional regulators [Transcription]; Region: COG1733
479433005965	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
479433005966	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
479433005967	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
479433005968	acyl-activating enzyme (AAE) consensus motif; other site
479433005969	putative AMP binding site [chemical binding]; other site
479433005970	putative active site [active]
479433005971	putative CoA binding site [chemical binding]; other site
479433005972	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
479433005973	UMP phosphatase; Provisional; Region: PRK10444
479433005974	active site
479433005975	motif I; other site
479433005976	motif II; other site
479433005977	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
479433005978	MgtC family; Region: MgtC; pfam02308
479433005979	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
479433005980	trimer interface [polypeptide binding]; other site
479433005981	active site
479433005982	substrate binding site [chemical binding]; other site
479433005983	CoA binding site [chemical binding]; other site
479433005984	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
479433005985	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
479433005986	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
479433005987	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
479433005988	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
479433005989	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
479433005990	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
479433005991	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
479433005992	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
479433005993	active site
479433005994	YibE/F-like protein; Region: YibE_F; pfam07907
479433005995	hypothetical protein; Provisional; Region: PRK02237
479433005996	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
479433005997	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
479433005998	hypothetical protein; Provisional; Region: PRK14013
479433005999	SnoaL-like domain; Region: SnoaL_4; pfam13577
479433006000	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
479433006001	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433006002	ATP binding site [chemical binding]; other site
479433006003	Mg2+ binding site [ion binding]; other site
479433006004	G-X-G motif; other site
479433006005	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
479433006006	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
479433006007	phosphopeptide binding site; other site
479433006008	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
479433006009	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
479433006010	phosphopeptide binding site; other site
479433006011	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
479433006012	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
479433006013	Walker A/P-loop; other site
479433006014	ATP binding site [chemical binding]; other site
479433006015	Q-loop/lid; other site
479433006016	ABC transporter signature motif; other site
479433006017	Walker B; other site
479433006018	D-loop; other site
479433006019	H-loop/switch region; other site
479433006020	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
479433006021	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
479433006022	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
479433006023	Baculovirus P47 protein; Region: Baculo_p47; cl17819
479433006024	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
479433006025	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
479433006026	ATP binding site [chemical binding]; other site
479433006027	putative Mg++ binding site [ion binding]; other site
479433006028	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
479433006029	nucleotide binding region [chemical binding]; other site
479433006030	ATP-binding site [chemical binding]; other site
479433006031	Helicase associated domain (HA2); Region: HA2; pfam04408
479433006032	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
479433006033	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
479433006034	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
479433006035	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
479433006036	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433006037	Walker B; other site
479433006038	D-loop; other site
479433006039	H-loop/switch region; other site
479433006040	ABC transporter; Region: ABC_tran_2; pfam12848
479433006041	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
479433006042	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
479433006043	Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686
479433006044	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
479433006045	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
479433006046	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433006047	catalytic residue [active]
479433006048	aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824
479433006049	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
479433006050	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190
479433006051	cleavage site
479433006052	active site
479433006053	substrate binding sites [chemical binding]; other site
479433006054	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
479433006055	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433006056	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433006057	putative substrate translocation pore; other site
479433006058	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
479433006059	active site
479433006060	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433006061	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
479433006062	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
479433006063	active site
479433006064	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
479433006065	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
479433006066	protein binding site [polypeptide binding]; other site
479433006067	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
479433006068	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
479433006069	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
479433006070	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
479433006071	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
479433006072	active site
479433006073	dimer interface [polypeptide binding]; other site
479433006074	motif 1; other site
479433006075	motif 2; other site
479433006076	motif 3; other site
479433006077	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
479433006078	anticodon binding site; other site
479433006079	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
479433006080	Active_site [active]
479433006081	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433006082	MarR family; Region: MarR_2; pfam12802
479433006083	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433006084	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
479433006085	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
479433006086	putative ADP-ribose binding site [chemical binding]; other site
479433006087	putative active site [active]
479433006088	Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
479433006089	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
479433006090	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433006091	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433006092	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433006093	Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney,  using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144
479433006094	putative FMN binding site [chemical binding]; other site
479433006095	putative dimer interface [polypeptide binding]; other site
479433006096	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
479433006097	active site
479433006098	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
479433006099	ligand binding site [chemical binding]; other site
479433006100	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
479433006101	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
479433006102	putative active site [active]
479433006103	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
479433006104	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
479433006105	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
479433006106	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
479433006107	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
479433006108	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
479433006109	putative active site [active]
479433006110	transaldolase; Provisional; Region: PRK03903
479433006111	catalytic residue [active]
479433006112	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
479433006113	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
479433006114	TPP-binding site [chemical binding]; other site
479433006115	dimer interface [polypeptide binding]; other site
479433006116	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
479433006117	PYR/PP interface [polypeptide binding]; other site
479433006118	dimer interface [polypeptide binding]; other site
479433006119	TPP binding site [chemical binding]; other site
479433006120	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
479433006121	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
479433006122	UbiA prenyltransferase family; Region: UbiA; pfam01040
479433006123	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
479433006124	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
479433006125	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
479433006126	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
479433006127	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
479433006128	ABC-2 type transporter; Region: ABC2_membrane; cl17235
479433006129	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433006130	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
479433006131	Walker A/P-loop; other site
479433006132	ATP binding site [chemical binding]; other site
479433006133	Q-loop/lid; other site
479433006134	ABC transporter signature motif; other site
479433006135	Walker B; other site
479433006136	D-loop; other site
479433006137	H-loop/switch region; other site
479433006138	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433006139	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433006140	DNA binding site [nucleotide binding]
479433006141	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433006142	dimerization interface [polypeptide binding]; other site
479433006143	ligand binding site [chemical binding]; other site
479433006144	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433006145	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433006146	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
479433006147	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433006148	putative PBP binding loops; other site
479433006149	dimer interface [polypeptide binding]; other site
479433006150	ABC-ATPase subunit interface; other site
479433006151	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433006152	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433006153	dimer interface [polypeptide binding]; other site
479433006154	conserved gate region; other site
479433006155	putative PBP binding loops; other site
479433006156	ABC-ATPase subunit interface; other site
479433006157	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
479433006158	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
479433006159	active site
479433006160	catalytic site [active]
479433006161	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261
479433006162	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
479433006163	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433006164	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433006165	active site
479433006166	catalytic tetrad [active]
479433006167	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433006168	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
479433006169	nucleotide binding site [chemical binding]; other site
479433006170	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
479433006171	Predicted transcriptional regulator [Transcription]; Region: COG2345
479433006172	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
479433006173	FeS assembly protein SufB; Region: sufB; TIGR01980
479433006174	FeS assembly protein SufD; Region: sufD; TIGR01981
479433006175	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
479433006176	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
479433006177	[2Fe-2S] cluster binding site [ion binding]; other site
479433006178	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
479433006179	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
479433006180	Walker A/P-loop; other site
479433006181	ATP binding site [chemical binding]; other site
479433006182	Q-loop/lid; other site
479433006183	ABC transporter signature motif; other site
479433006184	Walker B; other site
479433006185	D-loop; other site
479433006186	H-loop/switch region; other site
479433006187	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
479433006188	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
479433006189	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433006190	catalytic residue [active]
479433006191	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
479433006192	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
479433006193	trimerization site [polypeptide binding]; other site
479433006194	active site
479433006195	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
479433006196	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683
479433006197	nudix motif; other site
479433006198	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
479433006199	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
479433006200	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433006201	Walker A/P-loop; other site
479433006202	ATP binding site [chemical binding]; other site
479433006203	Q-loop/lid; other site
479433006204	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
479433006205	ABC transporter signature motif; other site
479433006206	Walker B; other site
479433006207	D-loop; other site
479433006208	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
479433006209	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
479433006210	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
479433006211	substrate binding site [chemical binding]; other site
479433006212	oxyanion hole (OAH) forming residues; other site
479433006213	trimer interface [polypeptide binding]; other site
479433006214	Alg9-like mannosyltransferase family; Region: Glyco_transf_22; cl17751
479433006215	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
479433006216	active site
479433006217	catalytic triad [active]
479433006218	oxyanion hole [active]
479433006219	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
479433006220	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
479433006221	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
479433006222	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433006223	Walker A/P-loop; other site
479433006224	ATP binding site [chemical binding]; other site
479433006225	Q-loop/lid; other site
479433006226	ABC transporter signature motif; other site
479433006227	Walker B; other site
479433006228	D-loop; other site
479433006229	H-loop/switch region; other site
479433006230	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
479433006231	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
479433006232	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
479433006233	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433006234	S-adenosylmethionine binding site [chemical binding]; other site
479433006235	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433006236	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
479433006237	hypothetical protein; Provisional; Region: PRK06194
479433006238	classical (c) SDRs; Region: SDR_c; cd05233
479433006239	NAD(P) binding site [chemical binding]; other site
479433006240	active site
479433006241	Amidohydrolase; Region: Amidohydro_2; pfam04909
479433006242	Amidohydrolase; Region: Amidohydro_2; pfam04909
479433006243	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
479433006244	active site
479433006245	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
479433006246	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
479433006247	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
479433006248	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
479433006249	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433006250	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433006251	DNA binding residues [nucleotide binding]
479433006252	dimerization interface [polypeptide binding]; other site
479433006253	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
479433006254	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433006255	FeS/SAM binding site; other site
479433006256	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
479433006257	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
479433006258	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
479433006259	tetramer interface [polypeptide binding]; other site
479433006260	active site
479433006261	Mg2+/Mn2+ binding site [ion binding]; other site
479433006262	DDE superfamily endonuclease; Region: DDE_1; pfam03184
479433006263	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
479433006264	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
479433006265	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
479433006266	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433006267	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
479433006268	NAD(P) binding site [chemical binding]; other site
479433006269	active site
479433006270	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
479433006271	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433006272	NAD(P) binding site [chemical binding]; other site
479433006273	active site
479433006274	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433006275	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433006276	putative substrate translocation pore; other site
479433006277	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433006278	putative substrate translocation pore; other site
479433006279	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
479433006280	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
479433006281	DNA binding residues [nucleotide binding]
479433006282	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433006283	putative substrate translocation pore; other site
479433006284	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433006285	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433006286	MarR family; Region: MarR; pfam01047
479433006287	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
479433006288	catalytic core [active]
479433006289	ACT domain; Region: ACT_6; pfam13740
479433006290	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
479433006291	phosphoserine phosphatase SerB; Region: serB; TIGR00338
479433006292	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
479433006293	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
479433006294	motif II; other site
479433006295	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
479433006296	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
479433006297	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433006298	Walker A/P-loop; other site
479433006299	ATP binding site [chemical binding]; other site
479433006300	Q-loop/lid; other site
479433006301	ABC transporter signature motif; other site
479433006302	Walker B; other site
479433006303	D-loop; other site
479433006304	H-loop/switch region; other site
479433006305	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
479433006306	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
479433006307	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
479433006308	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
479433006309	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
479433006310	putative homodimer interface [polypeptide binding]; other site
479433006311	active site
479433006312	SAM binding site [chemical binding]; other site
479433006313	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
479433006314	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
479433006315	putative FMN binding site [chemical binding]; other site
479433006316	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
479433006317	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
479433006318	putative dimer interface [polypeptide binding]; other site
479433006319	active site pocket [active]
479433006320	putative cataytic base [active]
479433006321	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
479433006322	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
479433006323	active site
479433006324	SAM binding site [chemical binding]; other site
479433006325	homodimer interface [polypeptide binding]; other site
479433006326	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433006327	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433006328	active site
479433006329	catalytic tetrad [active]
479433006330	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433006331	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433006332	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
479433006333	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
479433006334	Transcription factor WhiB; Region: Whib; pfam02467
479433006335	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433006336	non-specific DNA binding site [nucleotide binding]; other site
479433006337	salt bridge; other site
479433006338	sequence-specific DNA binding site [nucleotide binding]; other site
479433006339	hypothetical protein; Provisional; Region: PRK08244
479433006340	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
479433006341	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
479433006342	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
479433006343	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433006344	MMPL family; Region: MMPL; pfam03176
479433006345	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
479433006346	active site
479433006347	multimer interface [polypeptide binding]; other site
479433006348	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
479433006349	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
479433006350	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
479433006351	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
479433006352	RNA binding site [nucleotide binding]; other site
479433006353	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
479433006354	Peptidase family M50; Region: Peptidase_M50; pfam02163
479433006355	active site
479433006356	putative substrate binding region [chemical binding]; other site
479433006357	DEAD-like helicases superfamily; Region: DEXDc; smart00487
479433006358	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
479433006359	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
479433006360	ATP binding site [chemical binding]; other site
479433006361	putative Mg++ binding site [ion binding]; other site
479433006362	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
479433006363	nucleotide binding region [chemical binding]; other site
479433006364	ATP-binding site [chemical binding]; other site
479433006365	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
479433006366	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
479433006367	nucleotide binding site/active site [active]
479433006368	HIT family signature motif; other site
479433006369	catalytic residue [active]
479433006370	Protein of unknown function, DUF393; Region: DUF393; pfam04134
479433006371	Pretoxin HINT domain; Region: PT-HINT; pfam07591
479433006372	PknH-like extracellular domain; Region: PknH_C; pfam14032
479433006373	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
479433006374	elongation factor G; Reviewed; Region: PRK12740
479433006375	G1 box; other site
479433006376	putative GEF interaction site [polypeptide binding]; other site
479433006377	GTP/Mg2+ binding site [chemical binding]; other site
479433006378	Switch I region; other site
479433006379	G2 box; other site
479433006380	G3 box; other site
479433006381	Switch II region; other site
479433006382	G4 box; other site
479433006383	G5 box; other site
479433006384	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
479433006385	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
479433006386	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
479433006387	Transcriptional regulators [Transcription]; Region: FadR; COG2186
479433006388	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433006389	DNA-binding site [nucleotide binding]; DNA binding site
479433006390	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
479433006391	2-isopropylmalate synthase; Validated; Region: PRK03739
479433006392	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
479433006393	active site
479433006394	catalytic residues [active]
479433006395	metal binding site [ion binding]; metal-binding site
479433006396	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
479433006397	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
479433006398	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
479433006399	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
479433006400	putative acyl-acceptor binding pocket; other site
479433006401	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
479433006402	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
479433006403	CGNR zinc finger; Region: zf-CGNR; pfam11706
479433006404	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
479433006405	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
479433006406	active site
479433006407	multimer interface [polypeptide binding]; other site
479433006408	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
479433006409	predicted active site [active]
479433006410	catalytic triad [active]
479433006411	hypothetical protein; Validated; Region: PRK00110
479433006412	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
479433006413	active site
479433006414	putative DNA-binding cleft [nucleotide binding]; other site
479433006415	dimer interface [polypeptide binding]; other site
479433006416	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
479433006417	RuvA N terminal domain; Region: RuvA_N; pfam01330
479433006418	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
479433006419	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
479433006420	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433006421	Walker A motif; other site
479433006422	ATP binding site [chemical binding]; other site
479433006423	Walker B motif; other site
479433006424	arginine finger; other site
479433006425	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
479433006426	Preprotein translocase subunit; Region: YajC; pfam02699
479433006427	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
479433006428	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
479433006429	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
479433006430	Protein export membrane protein; Region: SecD_SecF; pfam02355
479433006431	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
479433006432	active site
479433006433	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
479433006434	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
479433006435	Zn2+ binding site [ion binding]; other site
479433006436	Mg2+ binding site [ion binding]; other site
479433006437	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
479433006438	synthetase active site [active]
479433006439	NTP binding site [chemical binding]; other site
479433006440	metal binding site [ion binding]; metal-binding site
479433006441	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
479433006442	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
479433006443	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
479433006444	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
479433006445	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
479433006446	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
479433006447	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
479433006448	active site
479433006449	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
479433006450	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
479433006451	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
479433006452	dimer interface [polypeptide binding]; other site
479433006453	motif 1; other site
479433006454	active site
479433006455	motif 2; other site
479433006456	motif 3; other site
479433006457	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
479433006458	anticodon binding site; other site
479433006459	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
479433006460	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
479433006461	dimer interface [polypeptide binding]; other site
479433006462	anticodon binding site; other site
479433006463	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
479433006464	homodimer interface [polypeptide binding]; other site
479433006465	motif 1; other site
479433006466	active site
479433006467	motif 2; other site
479433006468	GAD domain; Region: GAD; pfam02938
479433006469	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
479433006470	active site
479433006471	motif 3; other site
479433006472	Predicted membrane protein [Function unknown]; Region: COG2364
479433006473	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
479433006474	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
479433006475	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
479433006476	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433006477	DNA-binding site [nucleotide binding]; DNA binding site
479433006478	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
479433006479	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433006480	homodimer interface [polypeptide binding]; other site
479433006481	catalytic residue [active]
479433006482	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
479433006483	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433006484	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
479433006485	phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972
479433006486	Walker A/P-loop; other site
479433006487	ATP binding site [chemical binding]; other site
479433006488	Q-loop/lid; other site
479433006489	ABC transporter signature motif; other site
479433006490	Walker B; other site
479433006491	D-loop; other site
479433006492	H-loop/switch region; other site
479433006493	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433006494	recombination factor protein RarA; Reviewed; Region: PRK13342
479433006495	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433006496	Walker A motif; other site
479433006497	ATP binding site [chemical binding]; other site
479433006498	Walker B motif; other site
479433006499	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
479433006500	Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972
479433006501	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
479433006502	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
479433006503	motif 1; other site
479433006504	active site
479433006505	motif 2; other site
479433006506	motif 3; other site
479433006507	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
479433006508	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
479433006509	YceG-like family; Region: YceG; pfam02618
479433006510	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
479433006511	dimerization interface [polypeptide binding]; other site
479433006512	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
479433006513	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
479433006514	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
479433006515	shikimate binding site; other site
479433006516	NAD(P) binding site [chemical binding]; other site
479433006517	Family of unknown function (DUF566); Region: DUF566; pfam04484
479433006518	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
479433006519	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433006520	S-adenosylmethionine binding site [chemical binding]; other site
479433006521	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433006522	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433006523	active site
479433006524	ATP binding site [chemical binding]; other site
479433006525	substrate binding site [chemical binding]; other site
479433006526	activation loop (A-loop); other site
479433006527	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
479433006528	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433006529	Walker A/P-loop; other site
479433006530	ATP binding site [chemical binding]; other site
479433006531	Q-loop/lid; other site
479433006532	ABC transporter signature motif; other site
479433006533	Walker B; other site
479433006534	D-loop; other site
479433006535	H-loop/switch region; other site
479433006536	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
479433006537	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
479433006538	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
479433006539	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
479433006540	chorismate synthase; Validated; Region: PRK05382
479433006541	Tetramer interface [polypeptide binding]; other site
479433006542	active site
479433006543	FMN-binding site [chemical binding]; other site
479433006544	shikimate kinase; Reviewed; Region: aroK; PRK00131
479433006545	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
479433006546	ADP binding site [chemical binding]; other site
479433006547	magnesium binding site [ion binding]; other site
479433006548	putative shikimate binding site; other site
479433006549	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
479433006550	active site
479433006551	dimer interface [polypeptide binding]; other site
479433006552	metal binding site [ion binding]; metal-binding site
479433006553	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
479433006554	Dehydroquinase class II; Region: DHquinase_II; pfam01220
479433006555	trimer interface [polypeptide binding]; other site
479433006556	active site
479433006557	dimer interface [polypeptide binding]; other site
479433006558	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
479433006559	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
479433006560	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
479433006561	active site
479433006562	elongation factor P; Validated; Region: PRK00529
479433006563	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
479433006564	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
479433006565	RNA binding site [nucleotide binding]; other site
479433006566	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
479433006567	RNA binding site [nucleotide binding]; other site
479433006568	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
479433006569	putative RNA binding site [nucleotide binding]; other site
479433006570	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
479433006571	active site
479433006572	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
479433006573	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
479433006574	CGNR zinc finger; Region: zf-CGNR; pfam11706
479433006575	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433006576	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433006577	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433006578	non-specific DNA binding site [nucleotide binding]; other site
479433006579	salt bridge; other site
479433006580	sequence-specific DNA binding site [nucleotide binding]; other site
479433006581	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
479433006582	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
479433006583	active site
479433006584	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
479433006585	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
479433006586	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
479433006587	dihydroorotase; Validated; Region: pyrC; PRK09357
479433006588	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
479433006589	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
479433006590	active site
479433006591	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
479433006592	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
479433006593	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
479433006594	catalytic site [active]
479433006595	subunit interface [polypeptide binding]; other site
479433006596	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
479433006597	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
479433006598	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
479433006599	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
479433006600	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
479433006601	ATP-grasp domain; Region: ATP-grasp_4; cl17255
479433006602	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
479433006603	IMP binding site; other site
479433006604	dimer interface [polypeptide binding]; other site
479433006605	interdomain contacts; other site
479433006606	partial ornithine binding site; other site
479433006607	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
479433006608	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
479433006609	quinone interaction residues [chemical binding]; other site
479433006610	active site
479433006611	catalytic residues [active]
479433006612	FMN binding site [chemical binding]; other site
479433006613	substrate binding site [chemical binding]; other site
479433006614	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
479433006615	active site
479433006616	dimer interface [polypeptide binding]; other site
479433006617	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
479433006618	hydrophobic ligand binding site; other site
479433006619	Protein of unknown function (DUF419); Region: DUF419; pfam04237
479433006620	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433006621	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433006622	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
479433006623	catalytic motif [active]
479433006624	Zn binding site [ion binding]; other site
479433006625	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
479433006626	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
479433006627	motif II; other site
479433006628	Haemolytic domain; Region: Haemolytic; cl00506
479433006629	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
479433006630	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
479433006631	Peptidase family M50; Region: Peptidase_M50; pfam02163
479433006632	active site
479433006633	putative substrate binding region [chemical binding]; other site
479433006634	FOG: CBS domain [General function prediction only]; Region: COG0517
479433006635	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
479433006636	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
479433006637	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433006638	S-adenosylmethionine binding site [chemical binding]; other site
479433006639	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433006640	dimer interface [polypeptide binding]; other site
479433006641	conserved gate region; other site
479433006642	putative PBP binding loops; other site
479433006643	ABC-ATPase subunit interface; other site
479433006644	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433006645	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
479433006646	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433006647	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433006648	dimer interface [polypeptide binding]; other site
479433006649	conserved gate region; other site
479433006650	putative PBP binding loops; other site
479433006651	ABC-ATPase subunit interface; other site
479433006652	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
479433006653	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
479433006654	motif II; other site
479433006655	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
479433006656	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
479433006657	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
479433006658	proteasome ATPase; Region: pup_AAA; TIGR03689
479433006659	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433006660	Walker A motif; other site
479433006661	ATP binding site [chemical binding]; other site
479433006662	Walker B motif; other site
479433006663	arginine finger; other site
479433006664	proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
479433006665	Pup-like protein; Region: Pup; pfam05639
479433006666	proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690
479433006667	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
479433006668	active site
479433006669	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
479433006670	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
479433006671	active site
479433006672	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
479433006673	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
479433006674	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
479433006675	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
479433006676	LysE type translocator; Region: LysE; cl00565
479433006677	Protein of unknown function (DUF3866); Region: DUF3866; pfam12982
479433006678	Predicted transcriptional regulator [Transcription]; Region: COG2378
479433006679	WYL domain; Region: WYL; pfam13280
479433006680	Predicted transcriptional regulator [Transcription]; Region: COG2378
479433006681	WYL domain; Region: WYL; pfam13280
479433006682	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
479433006683	twin arginine translocase protein A; Provisional; Region: tatA; PRK00191
479433006684	Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
479433006685	diacylglycerol kinase; Reviewed; Region: PRK11914
479433006686	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
479433006687	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
479433006688	ATP binding site [chemical binding]; other site
479433006689	putative Mg++ binding site [ion binding]; other site
479433006690	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
479433006691	nucleotide binding region [chemical binding]; other site
479433006692	ATP-binding site [chemical binding]; other site
479433006693	rRNA-processing arch domain; Region: rRNA_proc-arch; pfam13234
479433006694	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
479433006695	5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739
479433006696	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
479433006697	active site
479433006698	metal binding site 1 [ion binding]; metal-binding site
479433006699	putative 5' ssDNA interaction site; other site
479433006700	metal binding site 3; metal-binding site
479433006701	metal binding site 2 [ion binding]; metal-binding site
479433006702	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
479433006703	putative DNA binding site [nucleotide binding]; other site
479433006704	putative metal binding site [ion binding]; other site
479433006705	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
479433006706	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
479433006707	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
479433006708	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433006709	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433006710	ATP binding site [chemical binding]; other site
479433006711	Mg2+ binding site [ion binding]; other site
479433006712	G-X-G motif; other site
479433006713	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
479433006714	Protein of unknown function (DUF742); Region: DUF742; pfam05331
479433006715	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
479433006716	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
479433006717	G1 box; other site
479433006718	GTP/Mg2+ binding site [chemical binding]; other site
479433006719	G2 box; other site
479433006720	Switch I region; other site
479433006721	G3 box; other site
479433006722	Switch II region; other site
479433006723	G4 box; other site
479433006724	G5 box; other site
479433006725	hypothetical protein; Reviewed; Region: PRK09588
479433006726	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
479433006727	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
479433006728	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
479433006729	hexamer interface [polypeptide binding]; other site
479433006730	ligand binding site [chemical binding]; other site
479433006731	putative active site [active]
479433006732	NAD(P) binding site [chemical binding]; other site
479433006733	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
479433006734	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
479433006735	active site
479433006736	Int/Topo IB signature motif; other site
479433006737	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
479433006738	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
479433006739	P-loop; other site
479433006740	Magnesium ion binding site [ion binding]; other site
479433006741	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
479433006742	Magnesium ion binding site [ion binding]; other site
479433006743	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
479433006744	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
479433006745	Septum formation; Region: Septum_form; pfam13845
479433006746	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
479433006747	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
479433006748	RNA binding surface [nucleotide binding]; other site
479433006749	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
479433006750	active site
479433006751	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433006752	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433006753	putative substrate translocation pore; other site
479433006754	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433006755	sequence-specific DNA binding site [nucleotide binding]; other site
479433006756	salt bridge; other site
479433006757	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
479433006758	homotrimer interaction site [polypeptide binding]; other site
479433006759	active site
479433006760	prephenate dehydrogenase; Validated; Region: PRK06545
479433006761	prephenate dehydrogenase; Validated; Region: PRK08507
479433006762	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
479433006763	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
479433006764	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
479433006765	active site
479433006766	metal binding site [ion binding]; metal-binding site
479433006767	DNA binding site [nucleotide binding]
479433006768	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433006769	AAA domain; Region: AAA_23; pfam13476
479433006770	Walker A/P-loop; other site
479433006771	ATP binding site [chemical binding]; other site
479433006772	Protein of unknown function (DUF445); Region: DUF445; pfam04286
479433006773	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
479433006774	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433006775	NAD(P) binding site [chemical binding]; other site
479433006776	active site
479433006777	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
479433006778	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
479433006779	structural tetrad; other site
479433006780	Predicted permease; Region: DUF318; cl17795
479433006781	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
479433006782	metal-binding site [ion binding]
479433006783	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
479433006784	Ligand binding site [chemical binding]; other site
479433006785	Electron transfer flavoprotein domain; Region: ETF; pfam01012
479433006786	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
479433006787	Ligand Binding Site [chemical binding]; other site
479433006788	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
479433006789	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
479433006790	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
479433006791	Protein of unknown function (DUF3810); Region: DUF3810; pfam12725
479433006792	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
479433006793	4Fe-4S binding domain; Region: Fer4; pfam00037
479433006794	Cysteine-rich domain; Region: CCG; pfam02754
479433006795	Cysteine-rich domain; Region: CCG; pfam02754
479433006796	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
479433006797	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
479433006798	motif II; other site
479433006799	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
479433006800	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433006801	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
479433006802	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
479433006803	SnoaL-like domain; Region: SnoaL_2; pfam12680
479433006804	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
479433006805	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
479433006806	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
479433006807	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
479433006808	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
479433006809	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
479433006810	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
479433006811	PAS domain S-box; Region: sensory_box; TIGR00229
479433006812	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
479433006813	putative active site [active]
479433006814	heme pocket [chemical binding]; other site
479433006815	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
479433006816	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
479433006817	metal binding site [ion binding]; metal-binding site
479433006818	active site
479433006819	I-site; other site
479433006820	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
479433006821	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
479433006822	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
479433006823	FAD binding domain; Region: FAD_binding_4; pfam01565
479433006824	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
479433006825	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
479433006826	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
479433006827	Cysteine-rich domain; Region: CCG; pfam02754
479433006828	Cysteine-rich domain; Region: CCG; pfam02754
479433006829	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
479433006830	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
479433006831	dimer interface [polypeptide binding]; other site
479433006832	active site
479433006833	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
479433006834	substrate binding site [chemical binding]; other site
479433006835	catalytic residue [active]
479433006836	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
479433006837	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
479433006838	homotrimer interaction site [polypeptide binding]; other site
479433006839	putative active site [active]
479433006840	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516
479433006841	CGNR zinc finger; Region: zf-CGNR; pfam11706
479433006842	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
479433006843	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
479433006844	active site
479433006845	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
479433006846	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433006847	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
479433006848	Cupin; Region: Cupin_6; pfam12852
479433006849	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
479433006850	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
479433006851	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433006852	NAD(P) binding site [chemical binding]; other site
479433006853	active site
479433006854	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
479433006855	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
479433006856	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
479433006857	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
479433006858	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
479433006859	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433006860	active site
479433006861	ATP binding site [chemical binding]; other site
479433006862	substrate binding site [chemical binding]; other site
479433006863	activation loop (A-loop); other site
479433006864	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cd04434
479433006865	active site
479433006866	zinc binding site [ion binding]; other site
479433006867	Restriction endonuclease; Region: Mrr_cat; pfam04471
479433006868	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
479433006869	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
479433006870	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
479433006871	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
479433006872	Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365
479433006873	Dodecin; Region: Dodecin; pfam07311
479433006874	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
479433006875	Domain of unknown function (DUF377); Region: DUF377; pfam04041
479433006876	active site
479433006877	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
479433006878	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
479433006879	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433006880	putative DNA binding site [nucleotide binding]; other site
479433006881	dimerization interface [polypeptide binding]; other site
479433006882	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433006883	putative Zn2+ binding site [ion binding]; other site
479433006884	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433006885	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
479433006886	Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719
479433006887	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433006888	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433006889	DNA binding site [nucleotide binding]
479433006890	domain linker motif; other site
479433006891	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433006892	dimerization interface [polypeptide binding]; other site
479433006893	ligand binding site [chemical binding]; other site
479433006894	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
479433006895	substrate binding site [chemical binding]; other site
479433006896	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
479433006897	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
479433006898	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433006899	Walker A/P-loop; other site
479433006900	ATP binding site [chemical binding]; other site
479433006901	Q-loop/lid; other site
479433006902	ABC transporter signature motif; other site
479433006903	Walker B; other site
479433006904	D-loop; other site
479433006905	H-loop/switch region; other site
479433006906	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
479433006907	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
479433006908	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433006909	dimer interface [polypeptide binding]; other site
479433006910	conserved gate region; other site
479433006911	putative PBP binding loops; other site
479433006912	ABC-ATPase subunit interface; other site
479433006913	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
479433006914	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
479433006915	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433006916	dimer interface [polypeptide binding]; other site
479433006917	conserved gate region; other site
479433006918	putative PBP binding loops; other site
479433006919	ABC-ATPase subunit interface; other site
479433006920	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
479433006921	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433006922	Walker A/P-loop; other site
479433006923	ATP binding site [chemical binding]; other site
479433006924	Q-loop/lid; other site
479433006925	ABC transporter signature motif; other site
479433006926	Walker B; other site
479433006927	D-loop; other site
479433006928	H-loop/switch region; other site
479433006929	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
479433006930	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
479433006931	beta-galactosidase; Region: BGL; TIGR03356
479433006932	RNA polymerase factor sigma-70; Validated; Region: PRK08241
479433006933	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433006934	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
479433006935	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
479433006936	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
479433006937	TIGR03086 family protein; Region: TIGR03086
479433006938	PHP domain; Region: PHP; pfam02811
479433006939	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
479433006940	active site
479433006941	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
479433006942	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
479433006943	active site
479433006944	metal binding site [ion binding]; metal-binding site
479433006945	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
479433006946	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
479433006947	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
479433006948	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433006949	DNA binding residues [nucleotide binding]
479433006950	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
479433006951	iron-sulfur cluster [ion binding]; other site
479433006952	[2Fe-2S] cluster binding site [ion binding]; other site
479433006953	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
479433006954	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433006955	Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790
479433006956	glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511
479433006957	glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511
479433006958	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
479433006959	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
479433006960	G1 box; other site
479433006961	GTP/Mg2+ binding site [chemical binding]; other site
479433006962	G2 box; other site
479433006963	Switch I region; other site
479433006964	G3 box; other site
479433006965	Switch II region; other site
479433006966	G4 box; other site
479433006967	G5 box; other site
479433006968	Protein of unknown function (DUF742); Region: DUF742; pfam05331
479433006969	Roadblock/LC7 domain; Region: Robl_LC7; pfam03259
479433006970	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
479433006971	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433006972	ATP binding site [chemical binding]; other site
479433006973	Mg2+ binding site [ion binding]; other site
479433006974	G-X-G motif; other site
479433006975	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
479433006976	hydroxyglutarate oxidase; Provisional; Region: PRK11728
479433006977	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
479433006978	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
479433006979	active site
479433006980	catalytic triad [active]
479433006981	calcium binding site [ion binding]; other site
479433006982	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433006983	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433006984	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433006985	active site
479433006986	catalytic tetrad [active]
479433006987	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
479433006988	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
479433006989	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
479433006990	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
479433006991	active site
479433006992	homotetramer interface [polypeptide binding]; other site
479433006993	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
479433006994	active site
479433006995	Hemerythrin-like domain; Region: Hr-like; cd12108
479433006996	Fe binding site [ion binding]; other site
479433006997	benzoate transport; Region: 2A0115; TIGR00895
479433006998	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433006999	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433007000	Melibiase; Region: Melibiase; pfam02065
479433007001	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
479433007002	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433007003	alpha-galactosidase; Region: PLN02808; cl17638
479433007004	Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081
479433007005	Ca binding site [ion binding]; other site
479433007006	SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830
479433007007	active site
479433007008	catalytic triad [active]
479433007009	oxyanion hole [active]
479433007010	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433007011	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433007012	short chain dehydrogenase; Provisional; Region: PRK08263
479433007013	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
479433007014	NADP binding site [chemical binding]; other site
479433007015	active site
479433007016	steroid binding site; other site
479433007017	transcription termination factor Rho; Provisional; Region: PRK12608
479433007018	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
479433007019	RNA binding site [nucleotide binding]; other site
479433007020	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
479433007021	Walker A motif; other site
479433007022	ATP binding site [chemical binding]; other site
479433007023	Walker B motif; other site
479433007024	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
479433007025	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
479433007026	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
479433007027	Cupin; Region: Cupin_6; pfam12852
479433007028	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
479433007029	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433007030	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
479433007031	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
479433007032	Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563
479433007033	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
479433007034	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433007035	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433007036	DNA binding site [nucleotide binding]
479433007037	domain linker motif; other site
479433007038	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433007039	ligand binding site [chemical binding]; other site
479433007040	dimerization interface [polypeptide binding]; other site
479433007041	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
479433007042	active site
479433007043	Family description; Region: VCBS; pfam13517
479433007044	Family description; Region: VCBS; pfam13517
479433007045	Family description; Region: VCBS; pfam13517
479433007046	Family description; Region: VCBS; pfam13517
479433007047	Family description; Region: VCBS; pfam13517
479433007048	Family description; Region: VCBS; pfam13517
479433007049	Family description; Region: VCBS; pfam13517
479433007050	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
479433007051	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433007052	AAA ATPase domain; Region: AAA_16; pfam13191
479433007053	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433007054	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433007055	Predicted membrane protein [Function unknown]; Region: COG3463
479433007056	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
479433007057	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
479433007058	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
479433007059	active site
479433007060	nucleophile elbow; other site
479433007061	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433007062	WHG domain; Region: WHG; pfam13305
479433007063	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
479433007064	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
479433007065	amidase; Provisional; Region: PRK06170
479433007066	Amidase; Region: Amidase; pfam01425
479433007067	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
479433007068	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433007069	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433007070	acyl-activating enzyme (AAE) consensus motif; other site
479433007071	acyl-activating enzyme (AAE) consensus motif; other site
479433007072	AMP binding site [chemical binding]; other site
479433007073	active site
479433007074	CoA binding site [chemical binding]; other site
479433007075	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433007076	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433007077	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
479433007078	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
479433007079	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433007080	Cytochrome P450; Region: p450; cl12078
479433007081	Protein of unknown function (DUF3224); Region: DUF3224; pfam11528
479433007082	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
479433007083	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
479433007084	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
479433007085	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
479433007086	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
479433007087	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
479433007088	FMN binding site [chemical binding]; other site
479433007089	substrate binding site [chemical binding]; other site
479433007090	putative catalytic residue [active]
479433007091	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
479433007092	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
479433007093	acyl-activating enzyme (AAE) consensus motif; other site
479433007094	AMP binding site [chemical binding]; other site
479433007095	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
479433007096	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
479433007097	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
479433007098	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
479433007099	ligand binding site [chemical binding]; other site
479433007100	flexible hinge region; other site
479433007101	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
479433007102	putative switch regulator; other site
479433007103	non-specific DNA interactions [nucleotide binding]; other site
479433007104	DNA binding site [nucleotide binding]
479433007105	sequence specific DNA binding site [nucleotide binding]; other site
479433007106	putative cAMP binding site [chemical binding]; other site
479433007107	Condensation domain; Region: Condensation; pfam00668
479433007108	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
479433007109	Condensation domain; Region: Condensation; pfam00668
479433007110	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
479433007111	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
479433007112	acyl-activating enzyme (AAE) consensus motif; other site
479433007113	AMP binding site [chemical binding]; other site
479433007114	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433007115	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
479433007116	putative FMN binding site [chemical binding]; other site
479433007117	NADPH bind site [chemical binding]; other site
479433007118	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
479433007119	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
479433007120	active site
479433007121	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
479433007122	3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425
479433007123	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
479433007124	dimer interface [polypeptide binding]; other site
479433007125	active site
479433007126	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
479433007127	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
479433007128	substrate binding site [chemical binding]; other site
479433007129	oxyanion hole (OAH) forming residues; other site
479433007130	trimer interface [polypeptide binding]; other site
479433007131	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
479433007132	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
479433007133	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433007134	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
479433007135	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
479433007136	active site
479433007137	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
479433007138	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
479433007139	putative NADP binding site [chemical binding]; other site
479433007140	active site
479433007141	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433007142	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
479433007143	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
479433007144	active site
479433007145	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
479433007146	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
479433007147	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
479433007148	putative NADP binding site [chemical binding]; other site
479433007149	KR domain; Region: KR; pfam08659
479433007150	active site
479433007151	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
479433007152	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
479433007153	active site
479433007154	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
479433007155	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
479433007156	substrate binding site [chemical binding]; other site
479433007157	oxyanion hole (OAH) forming residues; other site
479433007158	trimer interface [polypeptide binding]; other site
479433007159	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
479433007160	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
479433007161	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
479433007162	active site
479433007163	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
479433007164	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
479433007165	putative NADP binding site [chemical binding]; other site
479433007166	active site
479433007167	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433007168	S-adenosylmethionine binding site [chemical binding]; other site
479433007169	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
479433007170	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
479433007171	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
479433007172	active site
479433007173	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
479433007174	putative NADP binding site [chemical binding]; other site
479433007175	KR domain; Region: KR; pfam08659
479433007176	active site
479433007177	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433007178	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
479433007179	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
479433007180	active site
479433007181	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
479433007182	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
479433007183	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
479433007184	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
479433007185	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433007186	catalytic residue [active]
479433007187	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433007188	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
479433007189	Serine hydrolase (FSH1); Region: FSH1; pfam03959
479433007190	biosynthesis cluster domain; Region: biosyn_clust_1; TIGR04098
479433007191	acyl carrier protein; Validated; Region: PRK07117
479433007192	3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425
479433007193	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
479433007194	dimer interface [polypeptide binding]; other site
479433007195	active site
479433007196	acyl carrier protein; Validated; Region: PRK07117
479433007197	polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103
479433007198	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
479433007199	active site
479433007200	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
479433007201	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
479433007202	Aminotransferase class IV; Region: Aminotran_4; pfam01063
479433007203	substrate-cofactor binding pocket; other site
479433007204	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433007205	catalytic residue [active]
479433007206	alpha-glucosidase; Provisional; Region: PRK10426
479433007207	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
479433007208	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
479433007209	putative active site [active]
479433007210	putative catalytic site [active]
479433007211	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433007212	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433007213	dimer interface [polypeptide binding]; other site
479433007214	conserved gate region; other site
479433007215	putative PBP binding loops; other site
479433007216	ABC-ATPase subunit interface; other site
479433007217	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
479433007218	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433007219	dimer interface [polypeptide binding]; other site
479433007220	conserved gate region; other site
479433007221	putative PBP binding loops; other site
479433007222	ABC-ATPase subunit interface; other site
479433007223	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433007224	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433007225	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433007226	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433007227	DNA binding site [nucleotide binding]
479433007228	domain linker motif; other site
479433007229	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433007230	dimerization interface [polypeptide binding]; other site
479433007231	ligand binding site [chemical binding]; other site
479433007232	short chain dehydrogenase; Provisional; Region: PRK06197
479433007233	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
479433007234	putative NAD(P) binding site [chemical binding]; other site
479433007235	active site
479433007236	Predicted dehydrogenase [General function prediction only]; Region: COG0579
479433007237	hydroxyglutarate oxidase; Provisional; Region: PRK11728
479433007238	CsbD-like; Region: CsbD; cl17424
479433007239	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
479433007240	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
479433007241	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433007242	DNA-binding site [nucleotide binding]; DNA binding site
479433007243	UTRA domain; Region: UTRA; pfam07702
479433007244	Helix-turn-helix domain; Region: HTH_20; pfam12840
479433007245	putative DNA binding site [nucleotide binding]; other site
479433007246	putative Zn2+ binding site [ion binding]; other site
479433007247	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433007248	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
479433007249	nucleotide binding site [chemical binding]; other site
479433007250	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
479433007251	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
479433007252	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433007253	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
479433007254	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433007255	putative PBP binding loops; other site
479433007256	ABC-ATPase subunit interface; other site
479433007257	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433007258	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433007259	dimer interface [polypeptide binding]; other site
479433007260	conserved gate region; other site
479433007261	putative PBP binding loops; other site
479433007262	ABC-ATPase subunit interface; other site
479433007263	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
479433007264	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
479433007265	NAD(P) binding site [chemical binding]; other site
479433007266	catalytic residues [active]
479433007267	Amino acid permease; Region: AA_permease_2; pfam13520
479433007268	tyramine oxidase; Provisional; Region: tynA; PRK11504
479433007269	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
479433007270	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
479433007271	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
479433007272	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
479433007273	active site
479433007274	tetramer interface; other site
479433007275	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
479433007276	anti sigma factor interaction site; other site
479433007277	regulatory phosphorylation site [posttranslational modification]; other site
479433007278	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
479433007279	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433007280	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
479433007281	PAS domain; Region: PAS_9; pfam13426
479433007282	putative active site [active]
479433007283	heme pocket [chemical binding]; other site
479433007284	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
479433007285	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
479433007286	active site
479433007287	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433007288	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433007289	putative sugar binding sites [chemical binding]; other site
479433007290	Q-X-W motif; other site
479433007291	Predicted transcriptional regulator [Transcription]; Region: COG2345
479433007292	putative Zn2+ binding site [ion binding]; other site
479433007293	putative DNA binding site [nucleotide binding]; other site
479433007294	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
479433007295	dimerization interface [polypeptide binding]; other site
479433007296	GTP cyclohydrolase I; Provisional; Region: PLN03044
479433007297	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
479433007298	active site
479433007299	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
479433007300	ArsC family; Region: ArsC; pfam03960
479433007301	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
479433007302	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
479433007303	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
479433007304	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
479433007305	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
479433007306	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
479433007307	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
479433007308	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
479433007309	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
479433007310	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
479433007311	active site
479433007312	homotetramer interface [polypeptide binding]; other site
479433007313	Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542
479433007314	active site
479433007315	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
479433007316	YndJ-like protein; Region: YndJ; pfam14158
479433007317	YndJ-like protein; Region: YndJ; pfam14158
479433007318	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
479433007319	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
479433007320	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
479433007321	phosphopeptide binding site; other site
479433007322	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
479433007323	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
479433007324	dimerization interface [polypeptide binding]; other site
479433007325	ligand binding site [chemical binding]; other site
479433007326	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
479433007327	putative hydrophobic ligand binding site [chemical binding]; other site
479433007328	beta-D-glucuronidase; Provisional; Region: PRK10150
479433007329	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
479433007330	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
479433007331	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
479433007332	Probable galactinol--sucrose galactosyltransferase; Region: PLN02684
479433007333	Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082
479433007334	Ca binding site [ion binding]; other site
479433007335	Ca binding site (active) [ion binding]; other site
479433007336	ligand binding site [chemical binding]; other site
479433007337	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433007338	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433007339	active site
479433007340	phosphorylation site [posttranslational modification]
479433007341	intermolecular recognition site; other site
479433007342	dimerization interface [polypeptide binding]; other site
479433007343	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433007344	DNA binding residues [nucleotide binding]
479433007345	dimerization interface [polypeptide binding]; other site
479433007346	Histidine kinase; Region: HisKA_3; pfam07730
479433007347	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433007348	MMPL family; Region: MMPL; pfam03176
479433007349	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
479433007350	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
479433007351	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
479433007352	RNA binding site [nucleotide binding]; other site
479433007353	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
479433007354	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433007355	NAD(P) binding site [chemical binding]; other site
479433007356	active site
479433007357	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
479433007358	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
479433007359	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
479433007360	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
479433007361	AsnC family; Region: AsnC_trans_reg; pfam01037
479433007362	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433007363	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
479433007364	nucleotide binding site [chemical binding]; other site
479433007365	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433007366	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433007367	DNA binding site [nucleotide binding]
479433007368	domain linker motif; other site
479433007369	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433007370	dimerization interface [polypeptide binding]; other site
479433007371	ligand binding site [chemical binding]; other site
479433007372	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433007373	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433007374	DNA binding residues [nucleotide binding]
479433007375	dimerization interface [polypeptide binding]; other site
479433007376	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
479433007377	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
479433007378	haloalkane dehalogenase; Provisional; Region: PRK03592
479433007379	Predicted transcriptional regulators [Transcription]; Region: COG1733
479433007380	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
479433007381	Cutinase; Region: Cutinase; pfam01083
479433007382	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
479433007383	NlpC/P60 family; Region: NLPC_P60; cl17555
479433007384	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433007385	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433007386	active site
479433007387	ATP binding site [chemical binding]; other site
479433007388	substrate binding site [chemical binding]; other site
479433007389	activation loop (A-loop); other site
479433007390	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
479433007391	N-acetyl-D-glucosamine binding site [chemical binding]; other site
479433007392	catalytic residue [active]
479433007393	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
479433007394	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
479433007395	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
479433007396	putative active site [active]
479433007397	catalytic site [active]
479433007398	Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105
479433007399	putative active site [active]
479433007400	catalytic site [active]
479433007401	Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306
479433007402	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433007403	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433007404	dimer interface [polypeptide binding]; other site
479433007405	conserved gate region; other site
479433007406	putative PBP binding loops; other site
479433007407	ABC-ATPase subunit interface; other site
479433007408	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433007409	dimer interface [polypeptide binding]; other site
479433007410	conserved gate region; other site
479433007411	ABC-ATPase subunit interface; other site
479433007412	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433007413	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433007414	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022
479433007415	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
479433007416	DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014
479433007417	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433007418	dimerization interface [polypeptide binding]; other site
479433007419	ligand binding site [chemical binding]; other site
479433007420	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167
479433007421	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
479433007422	putative ligand binding site [chemical binding]; other site
479433007423	putative NAD binding site [chemical binding]; other site
479433007424	catalytic site [active]
479433007425	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
479433007426	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
479433007427	S-adenosylmethionine binding site [chemical binding]; other site
479433007428	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
479433007429	hydrophobic ligand binding site; other site
479433007430	Domain of unknown function (DUF4331); Region: DUF4331; pfam14224
479433007431	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433007432	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
479433007433	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433007434	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433007435	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
479433007436	putative dimerization interface [polypeptide binding]; other site
479433007437	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
479433007438	Predicted flavoprotein [General function prediction only]; Region: COG0431
479433007439	Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788
479433007440	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
479433007441	homodimer interface [polypeptide binding]; other site
479433007442	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
479433007443	active site
479433007444	TDP-binding site; other site
479433007445	acceptor substrate-binding pocket; other site
479433007446	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
479433007447	legume lectins; Region: lectin_L-type; cl14058
479433007448	homotetramer interaction site [polypeptide binding]; other site
479433007449	carbohydrate binding site [chemical binding]; other site
479433007450	metal binding site [ion binding]; metal-binding site
479433007451	legume lectins; Region: lectin_L-type; cl14058
479433007452	homotetramer interaction site [polypeptide binding]; other site
479433007453	carbohydrate binding site [chemical binding]; other site
479433007454	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433007455	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433007456	putative substrate translocation pore; other site
479433007457	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433007458	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
479433007459	DEAD-like helicases superfamily; Region: DEXDc; smart00487
479433007460	ATP binding site [chemical binding]; other site
479433007461	putative Mg++ binding site [ion binding]; other site
479433007462	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
479433007463	nucleotide binding region [chemical binding]; other site
479433007464	ATP-binding site [chemical binding]; other site
479433007465	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
479433007466	DNA-binding site [nucleotide binding]; DNA binding site
479433007467	RNA-binding motif; other site
479433007468	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
479433007469	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
479433007470	DNA binding residues [nucleotide binding]
479433007471	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
479433007472	HSP70 interaction site [polypeptide binding]; other site
479433007473	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
479433007474	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
479433007475	putative dimer interface [polypeptide binding]; other site
479433007476	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
479433007477	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
479433007478	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
479433007479	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
479433007480	catalytic Zn binding site [ion binding]; other site
479433007481	NAD binding site [chemical binding]; other site
479433007482	structural Zn binding site [ion binding]; other site
479433007483	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
479433007484	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
479433007485	NAD(P) binding site [chemical binding]; other site
479433007486	catalytic residues [active]
479433007487	Protein of unknown function (DUF556); Region: DUF556; pfam04476
479433007488	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
479433007489	EF-hand domain pair; Region: EF_hand_5; pfam13499
479433007490	Ca2+ binding site [ion binding]; other site
479433007491	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
479433007492	EF-hand domain pair; Region: EF_hand_5; pfam13499
479433007493	Ca2+ binding site [ion binding]; other site
479433007494	Domain of unknown function (DUF389); Region: DUF389; pfam04087
479433007495	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
479433007496	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
479433007497	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
479433007498	threonine synthase; Validated; Region: PRK07591
479433007499	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
479433007500	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433007501	catalytic residue [active]
479433007502	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
479433007503	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433007504	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433007505	acyl-activating enzyme (AAE) consensus motif; other site
479433007506	AMP binding site [chemical binding]; other site
479433007507	active site
479433007508	CoA binding site [chemical binding]; other site
479433007509	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
479433007510	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433007511	NAD(P) binding site [chemical binding]; other site
479433007512	active site
479433007513	Plasmodium Vir superfamily; Provisional; Region: PTZ00473
479433007514	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
479433007515	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433007516	NAD(P) binding site [chemical binding]; other site
479433007517	active site
479433007518	MbtH-like protein; Region: MbtH; pfam03621
479433007519	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433007520	Cytochrome P450; Region: p450; cl12078
479433007521	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
479433007522	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
479433007523	acyl-activating enzyme (AAE) consensus motif; other site
479433007524	AMP binding site [chemical binding]; other site
479433007525	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433007526	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
479433007527	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
479433007528	RNA ligase; Region: RNA_lig_T4_1; cl09743
479433007529	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433007530	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433007531	DNA binding residues [nucleotide binding]
479433007532	dimerization interface [polypeptide binding]; other site
479433007533	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433007534	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433007535	putative substrate translocation pore; other site
479433007536	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433007537	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433007538	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
479433007539	Cellulose binding domain; Region: CBM_2; pfam00553
479433007540	Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206
479433007541	Cellulose binding domain; Region: CBM_2; pfam00553
479433007542	Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206
479433007543	putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315
479433007544	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
479433007545	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
479433007546	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
479433007547	catalytic loop [active]
479433007548	iron binding site [ion binding]; other site
479433007549	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
479433007550	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
479433007551	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
479433007552	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
479433007553	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
479433007554	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
479433007555	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433007556	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433007557	putative sugar binding sites [chemical binding]; other site
479433007558	Q-X-W motif; other site
479433007559	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
479433007560	Ricin-type beta-trefoil; Region: RICIN; smart00458
479433007561	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433007562	putative sugar binding sites [chemical binding]; other site
479433007563	Q-X-W motif; other site
479433007564	Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031
479433007565	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
479433007566	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433007567	S-adenosylmethionine binding site [chemical binding]; other site
479433007568	Condensation domain; Region: Condensation; pfam00668
479433007569	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433007570	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433007571	dimer interface [polypeptide binding]; other site
479433007572	conserved gate region; other site
479433007573	putative PBP binding loops; other site
479433007574	ABC-ATPase subunit interface; other site
479433007575	Cellulose binding domain; Region: CBM_2; pfam00553
479433007576	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
479433007577	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
479433007578	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433007579	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433007580	putative sugar binding sites [chemical binding]; other site
479433007581	Q-X-W motif; other site
479433007582	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
479433007583	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433007584	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433007585	putative substrate translocation pore; other site
479433007586	MarR family; Region: MarR; pfam01047
479433007587	SnoaL-like domain; Region: SnoaL_2; pfam12680
479433007588	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433007589	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433007590	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433007591	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433007592	putative substrate translocation pore; other site
479433007593	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
479433007594	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
479433007595	TIGR03086 family protein; Region: TIGR03086
479433007596	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433007597	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433007598	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
479433007599	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
479433007600	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
479433007601	Rrf2 family protein; Region: rrf2_super; TIGR00738
479433007602	Transcriptional regulator; Region: Rrf2; pfam02082
479433007603	Cupin domain; Region: Cupin_2; cl17218
479433007604	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
479433007605	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
479433007606	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
479433007607	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
479433007608	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433007609	dimer interface [polypeptide binding]; other site
479433007610	conserved gate region; other site
479433007611	putative PBP binding loops; other site
479433007612	ABC-ATPase subunit interface; other site
479433007613	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
479433007614	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433007615	dimer interface [polypeptide binding]; other site
479433007616	conserved gate region; other site
479433007617	ABC-ATPase subunit interface; other site
479433007618	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
479433007619	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433007620	Walker A/P-loop; other site
479433007621	ATP binding site [chemical binding]; other site
479433007622	Q-loop/lid; other site
479433007623	ABC transporter signature motif; other site
479433007624	Walker B; other site
479433007625	D-loop; other site
479433007626	H-loop/switch region; other site
479433007627	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
479433007628	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433007629	Walker A/P-loop; other site
479433007630	ATP binding site [chemical binding]; other site
479433007631	Q-loop/lid; other site
479433007632	ABC transporter signature motif; other site
479433007633	Walker B; other site
479433007634	D-loop; other site
479433007635	H-loop/switch region; other site
479433007636	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
479433007637	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
479433007638	active site
479433007639	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
479433007640	dimer interface [polypeptide binding]; other site
479433007641	non-prolyl cis peptide bond; other site
479433007642	insertion regions; other site
479433007643	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
479433007644	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
479433007645	molybdopterin cofactor binding site; other site
479433007646	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
479433007647	molybdopterin cofactor binding site; other site
479433007648	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433007649	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
479433007650	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
479433007651	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
479433007652	active site
479433007653	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
479433007654	dimer interface [polypeptide binding]; other site
479433007655	non-prolyl cis peptide bond; other site
479433007656	insertion regions; other site
479433007657	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
479433007658	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
479433007659	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
479433007660	active site
479433007661	dimer interface [polypeptide binding]; other site
479433007662	non-prolyl cis peptide bond; other site
479433007663	insertion regions; other site
479433007664	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
479433007665	active site clefts [active]
479433007666	zinc binding site [ion binding]; other site
479433007667	dimer interface [polypeptide binding]; other site
479433007668	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
479433007669	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
479433007670	substrate binding pocket [chemical binding]; other site
479433007671	membrane-bound complex binding site; other site
479433007672	hinge residues; other site
479433007673	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433007674	dimer interface [polypeptide binding]; other site
479433007675	conserved gate region; other site
479433007676	putative PBP binding loops; other site
479433007677	ABC-ATPase subunit interface; other site
479433007678	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
479433007679	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
479433007680	Walker A/P-loop; other site
479433007681	ATP binding site [chemical binding]; other site
479433007682	Q-loop/lid; other site
479433007683	ABC transporter signature motif; other site
479433007684	Walker B; other site
479433007685	D-loop; other site
479433007686	H-loop/switch region; other site
479433007687	short chain dehydrogenase; Provisional; Region: PRK12747
479433007688	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433007689	NAD(P) binding site [chemical binding]; other site
479433007690	active site
479433007691	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433007692	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433007693	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433007694	non-specific DNA binding site [nucleotide binding]; other site
479433007695	salt bridge; other site
479433007696	sequence-specific DNA binding site [nucleotide binding]; other site
479433007697	NB-ARC domain; Region: NB-ARC; pfam00931
479433007698	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433007699	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433007700	TPR motif; other site
479433007701	binding surface
479433007702	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433007703	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433007704	putative substrate translocation pore; other site
479433007705	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
479433007706	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433007707	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433007708	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433007709	dimer interface [polypeptide binding]; other site
479433007710	conserved gate region; other site
479433007711	putative PBP binding loops; other site
479433007712	ABC-ATPase subunit interface; other site
479433007713	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433007714	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433007715	dimer interface [polypeptide binding]; other site
479433007716	conserved gate region; other site
479433007717	putative PBP binding loops; other site
479433007718	ABC-ATPase subunit interface; other site
479433007719	Phosphotransferase enzyme family; Region: APH; pfam01636
479433007720	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
479433007721	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
479433007722	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433007723	Walker A/P-loop; other site
479433007724	ATP binding site [chemical binding]; other site
479433007725	Q-loop/lid; other site
479433007726	ABC transporter signature motif; other site
479433007727	Walker B; other site
479433007728	D-loop; other site
479433007729	H-loop/switch region; other site
479433007730	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433007731	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433007732	WHG domain; Region: WHG; pfam13305
479433007733	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433007734	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
479433007735	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
479433007736	Cellulose binding domain; Region: CBM_2; pfam00553
479433007737	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
479433007738	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
479433007739	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
479433007740	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
479433007741	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433007742	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
479433007743	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433007744	dimer interface [polypeptide binding]; other site
479433007745	phosphorylation site [posttranslational modification]
479433007746	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433007747	ATP binding site [chemical binding]; other site
479433007748	Mg2+ binding site [ion binding]; other site
479433007749	G-X-G motif; other site
479433007750	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433007751	active site
479433007752	phosphorylation site [posttranslational modification]
479433007753	intermolecular recognition site; other site
479433007754	dimerization interface [polypeptide binding]; other site
479433007755	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
479433007756	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433007757	active site
479433007758	phosphorylation site [posttranslational modification]
479433007759	intermolecular recognition site; other site
479433007760	dimerization interface [polypeptide binding]; other site
479433007761	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
479433007762	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
479433007763	anti sigma factor interaction site; other site
479433007764	regulatory phosphorylation site [posttranslational modification]; other site
479433007765	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433007766	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433007767	ATP binding site [chemical binding]; other site
479433007768	Mg2+ binding site [ion binding]; other site
479433007769	G-X-G motif; other site
479433007770	Domain of unknown function (DUF4265); Region: DUF4265; pfam14085
479433007771	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433007772	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433007773	DNA binding residues [nucleotide binding]
479433007774	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
479433007775	SnoaL-like domain; Region: SnoaL_2; pfam12680
479433007776	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
479433007777	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
479433007778	DNA binding residues [nucleotide binding]
479433007779	drug binding residues [chemical binding]; other site
479433007780	dimer interface [polypeptide binding]; other site
479433007781	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
479433007782	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433007783	dimerization interface [polypeptide binding]; other site
479433007784	putative DNA binding site [nucleotide binding]; other site
479433007785	putative Zn2+ binding site [ion binding]; other site
479433007786	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900
479433007787	putative hydrophobic ligand binding site [chemical binding]; other site
479433007788	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
479433007789	Helix-turn-helix domain; Region: HTH_17; cl17695
479433007790	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
479433007791	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
479433007792	putative active site [active]
479433007793	putative metal binding residues [ion binding]; other site
479433007794	signature motif; other site
479433007795	putative triphosphate binding site [ion binding]; other site
479433007796	dimer interface [polypeptide binding]; other site
479433007797	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433007798	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433007799	non-specific DNA binding site [nucleotide binding]; other site
479433007800	salt bridge; other site
479433007801	sequence-specific DNA binding site [nucleotide binding]; other site
479433007802	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
479433007803	active site
479433007804	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
479433007805	PLD-like domain; Region: PLDc_2; pfam13091
479433007806	putative active site [active]
479433007807	catalytic site [active]
479433007808	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
479433007809	active site
479433007810	oxyanion hole [active]
479433007811	catalytic triad [active]
479433007812	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
479433007813	Phage capsid family; Region: Phage_capsid; pfam05065
479433007814	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
479433007815	oligomer interface [polypeptide binding]; other site
479433007816	active site residues [active]
479433007817	Phage-related protein [Function unknown]; Region: COG4695; cl01923
479433007818	Phage portal protein; Region: Phage_portal; pfam04860
479433007819	Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306
479433007820	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
479433007821	Terminase-like family; Region: Terminase_6; pfam03237
479433007822	Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863
479433007823	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
479433007824	Protein of unknown function (DUF2637); Region: DUF2637; pfam10935
479433007825	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433007826	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433007827	Helix-turn-helix domain; Region: HTH_17; cl17695
479433007828	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
479433007829	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433007830	DNA-binding site [nucleotide binding]; DNA binding site
479433007831	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
479433007832	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
479433007833	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
479433007834	replicative DNA helicase; Region: DnaB; TIGR00665
479433007835	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
479433007836	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
479433007837	Walker A motif; other site
479433007838	ATP binding site [chemical binding]; other site
479433007839	Walker B motif; other site
479433007840	DNA binding loops [nucleotide binding]
479433007841	UTRA domain; Region: UTRA; cl17743
479433007842	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
479433007843	T5orf172 domain; Region: T5orf172; pfam10544
479433007844	hypothetical protein; Provisional; Region: PRK07505
479433007845	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
479433007846	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533
479433007847	homodimer interface [polypeptide binding]; other site
479433007848	metal binding site [ion binding]; metal-binding site
479433007849	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
479433007850	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
479433007851	ADP-ribose binding site [chemical binding]; other site
479433007852	methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188
479433007853	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433007854	S-adenosylmethionine binding site [chemical binding]; other site
479433007855	Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047
479433007856	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
479433007857	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
479433007858	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
479433007859	putative DNA binding site [nucleotide binding]; other site
479433007860	putative homodimer interface [polypeptide binding]; other site
479433007861	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
479433007862	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
479433007863	Probable transposase; Region: OrfB_IS605; pfam01385
479433007864	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
479433007865	polynucleotide kinase; Provisional; Region: pseT; PHA02530
479433007866	RNA ligase; Region: RNA_lig_T4_1; pfam09511
479433007867	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
479433007868	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
479433007869	non-specific DNA binding site [nucleotide binding]; other site
479433007870	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
479433007871	salt bridge; other site
479433007872	sequence-specific DNA binding site [nucleotide binding]; other site
479433007873	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
479433007874	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433007875	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433007876	DNA binding residues [nucleotide binding]
479433007877	dimerization interface [polypeptide binding]; other site
479433007878	Transcription factor WhiB; Region: Whib; pfam02467
479433007879	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
479433007880	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
479433007881	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
479433007882	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
479433007883	dimer interface [polypeptide binding]; other site
479433007884	ssDNA binding site [nucleotide binding]; other site
479433007885	tetramer (dimer of dimers) interface [polypeptide binding]; other site
479433007886	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
479433007887	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
479433007888	active site
479433007889	ParB-like nuclease domain; Region: ParB; smart00470
479433007890	Protein of unknown function (DUF1643); Region: DUF1643; pfam07799
479433007891	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433007892	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433007893	DNA binding site [nucleotide binding]
479433007894	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
479433007895	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
479433007896	cofactor binding site; other site
479433007897	DNA binding site [nucleotide binding]
479433007898	substrate interaction site [chemical binding]; other site
479433007899	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
479433007900	Endodeoxyribonuclease RusA; Region: RusA; cl01885
479433007901	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
479433007902	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
479433007903	HNH endonuclease; Region: HNH_3; pfam13392
479433007904	RecT family; Region: RecT; cl04285
479433007905	YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588
479433007906	SPRY domain; Region: SPRY; cl02614
479433007907	Helix-turn-helix domain; Region: HTH_17; cl17695
479433007908	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
479433007909	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
479433007910	active site
479433007911	catalytic residues [active]
479433007912	DNA binding site [nucleotide binding]
479433007913	Int/Topo IB signature motif; other site
479433007914	GTP-binding protein Der; Reviewed; Region: PRK03003
479433007915	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
479433007916	G1 box; other site
479433007917	GTP/Mg2+ binding site [chemical binding]; other site
479433007918	Switch I region; other site
479433007919	G2 box; other site
479433007920	Switch II region; other site
479433007921	G3 box; other site
479433007922	G4 box; other site
479433007923	G5 box; other site
479433007924	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
479433007925	G1 box; other site
479433007926	GTP/Mg2+ binding site [chemical binding]; other site
479433007927	Switch I region; other site
479433007928	G2 box; other site
479433007929	G3 box; other site
479433007930	Switch II region; other site
479433007931	G4 box; other site
479433007932	G5 box; other site
479433007933	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
479433007934	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
479433007935	putative acyl-acceptor binding pocket; other site
479433007936	cytidylate kinase; Provisional; Region: cmk; PRK00023
479433007937	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
479433007938	CMP-binding site; other site
479433007939	The sites determining sugar specificity; other site
479433007940	The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6,  and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348
479433007941	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433007942	putative active site [active]
479433007943	putative metal binding site [ion binding]; other site
479433007944	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
479433007945	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
479433007946	CopC domain; Region: CopC; pfam04234
479433007947	Copper resistance protein D; Region: CopD; cl00563
479433007948	YtkA-like; Region: YtkA; pfam13115
479433007949	Protein of unknown function (DUF461); Region: DUF461; pfam04314
479433007950	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
479433007951	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
479433007952	Cu(I) binding site [ion binding]; other site
479433007953	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
479433007954	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
479433007955	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
479433007956	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
479433007957	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
479433007958	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
479433007959	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
479433007960	Protein of unknown function DUF58; Region: DUF58; pfam01882
479433007961	MoxR-like ATPases [General function prediction only]; Region: COG0714
479433007962	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433007963	ATP binding site [chemical binding]; other site
479433007964	Walker A motif; other site
479433007965	Walker B motif; other site
479433007966	arginine finger; other site
479433007967	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
479433007968	FOG: CBS domain [General function prediction only]; Region: COG0517
479433007969	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
479433007970	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
479433007971	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
479433007972	active site residue [active]
479433007973	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
479433007974	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
479433007975	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433007976	dimer interface [polypeptide binding]; other site
479433007977	conserved gate region; other site
479433007978	ABC-ATPase subunit interface; other site
479433007979	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433007980	dimer interface [polypeptide binding]; other site
479433007981	conserved gate region; other site
479433007982	putative PBP binding loops; other site
479433007983	ABC-ATPase subunit interface; other site
479433007984	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
479433007985	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
479433007986	Walker A/P-loop; other site
479433007987	ATP binding site [chemical binding]; other site
479433007988	Q-loop/lid; other site
479433007989	ABC transporter signature motif; other site
479433007990	Walker B; other site
479433007991	D-loop; other site
479433007992	H-loop/switch region; other site
479433007993	Nitronate monooxygenase; Region: NMO; pfam03060
479433007994	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
479433007995	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
479433007996	FMN binding site [chemical binding]; other site
479433007997	substrate binding site [chemical binding]; other site
479433007998	putative catalytic residue [active]
479433007999	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433008000	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
479433008001	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
479433008002	acyl-activating enzyme (AAE) consensus motif; other site
479433008003	putative AMP binding site [chemical binding]; other site
479433008004	putative active site [active]
479433008005	putative CoA binding site [chemical binding]; other site
479433008006	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
479433008007	DUF35 OB-fold domain; Region: DUF35; pfam01796
479433008008	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
479433008009	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
479433008010	DUF35 OB-fold domain; Region: DUF35; pfam01796
479433008011	lipid-transfer protein; Provisional; Region: PRK07937
479433008012	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
479433008013	active site
479433008014	acetyl-CoA acetyltransferase; Provisional; Region: PRK08313
479433008015	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
479433008016	active site
479433008017	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
479433008018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433008019	Walker A/P-loop; other site
479433008020	ATP binding site [chemical binding]; other site
479433008021	Q-loop/lid; other site
479433008022	ABC transporter signature motif; other site
479433008023	Walker B; other site
479433008024	D-loop; other site
479433008025	H-loop/switch region; other site
479433008026	TOBE domain; Region: TOBE_2; pfam08402
479433008027	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
479433008028	primosome assembly protein PriA; Provisional; Region: PRK14873
479433008029	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
479433008030	active site
479433008031	catalytic residues [active]
479433008032	metal binding site [ion binding]; metal-binding site
479433008033	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
479433008034	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
479433008035	putative active site [active]
479433008036	substrate binding site [chemical binding]; other site
479433008037	putative cosubstrate binding site; other site
479433008038	catalytic site [active]
479433008039	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
479433008040	substrate binding site [chemical binding]; other site
479433008041	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
479433008042	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
479433008043	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
479433008044	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
479433008045	Zn binding site [ion binding]; other site
479433008046	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748
479433008047	classical (c) SDRs; Region: SDR_c; cd05233
479433008048	NAD(P) binding site [chemical binding]; other site
479433008049	active site
479433008050	AMP-binding domain protein; Validated; Region: PRK08315
479433008051	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433008052	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
479433008053	acyl-activating enzyme (AAE) consensus motif; other site
479433008054	putative AMP binding site [chemical binding]; other site
479433008055	putative active site [active]
479433008056	putative CoA binding site [chemical binding]; other site
479433008057	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
479433008058	dimerization interface [polypeptide binding]; other site
479433008059	DNA binding residues [nucleotide binding]
479433008060	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
479433008061	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
479433008062	substrate binding site [chemical binding]; other site
479433008063	hexamer interface [polypeptide binding]; other site
479433008064	metal binding site [ion binding]; metal-binding site
479433008065	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433008066	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433008067	active site
479433008068	ATP binding site [chemical binding]; other site
479433008069	substrate binding site [chemical binding]; other site
479433008070	activation loop (A-loop); other site
479433008071	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
479433008072	Lumazine binding domain; Region: Lum_binding; pfam00677
479433008073	Lumazine binding domain; Region: Lum_binding; pfam00677
479433008074	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
479433008075	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
479433008076	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
479433008077	dimerization interface [polypeptide binding]; other site
479433008078	active site
479433008079	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
479433008080	homopentamer interface [polypeptide binding]; other site
479433008081	active site
479433008082	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
479433008083	metal binding site [ion binding]; metal-binding site
479433008084	Right handed beta helix region; Region: Beta_helix; pfam13229
479433008085	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
479433008086	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
479433008087	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433008088	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433008089	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433008090	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
479433008091	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
479433008092	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
479433008093	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
479433008094	leucine export protein LeuE; Provisional; Region: PRK10958
479433008095	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605
479433008096	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
479433008097	acyl-activating enzyme (AAE) consensus motif; other site
479433008098	putative AMP binding site [chemical binding]; other site
479433008099	putative active site [active]
479433008100	putative CoA binding site [chemical binding]; other site
479433008101	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
479433008102	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
479433008103	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
479433008104	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433008105	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433008106	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
479433008107	DNA binding residues [nucleotide binding]
479433008108	lipid-transfer protein; Provisional; Region: PRK06059
479433008109	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
479433008110	active site
479433008111	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
479433008112	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
479433008113	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433008114	MarR family; Region: MarR_2; pfam12802
479433008115	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
479433008116	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
479433008117	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
479433008118	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
479433008119	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
479433008120	lipoyl attachment site [posttranslational modification]; other site
479433008121	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
479433008122	Double zinc ribbon; Region: DZR; pfam12773
479433008123	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
479433008124	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
479433008125	phosphopeptide binding site; other site
479433008126	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
479433008127	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
479433008128	DNA binding residues [nucleotide binding]
479433008129	dimer interface [polypeptide binding]; other site
479433008130	Bifunctional nuclease; Region: DNase-RNase; pfam02577
479433008131	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
479433008132	DNA binding residues [nucleotide binding]
479433008133	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
479433008134	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
479433008135	putative active site [active]
479433008136	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
479433008137	active site
479433008138	Low molecular weight phosphatase family; Region: LMWPc; cd00115
479433008139	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
479433008140	active site
479433008141	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433008142	active site
479433008143	YCII-related domain; Region: YCII; cl00999
479433008144	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
479433008145	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
479433008146	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
479433008147	TPR motif; other site
479433008148	binding surface
479433008149	RNA polymerase factor sigma-70; Validated; Region: PRK08241
479433008150	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433008151	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
479433008152	DNA binding residues [nucleotide binding]
479433008153	SnoaL-like domain; Region: SnoaL_2; pfam12680
479433008154	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433008155	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433008156	putative substrate translocation pore; other site
479433008157	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
479433008158	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
479433008159	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
479433008160	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
479433008161	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
479433008162	hypothetical protein; Validated; Region: PRK00153
479433008163	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
479433008164	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
479433008165	Protein of unknown function (DUF2984); Region: DUF2984; cl12752
479433008166	Protein of unknown function (DUF690); Region: DUF690; cl04939
479433008167	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
479433008168	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433008169	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433008170	ATP binding site [chemical binding]; other site
479433008171	Mg2+ binding site [ion binding]; other site
479433008172	G-X-G motif; other site
479433008173	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433008174	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433008175	active site
479433008176	phosphorylation site [posttranslational modification]
479433008177	intermolecular recognition site; other site
479433008178	dimerization interface [polypeptide binding]; other site
479433008179	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433008180	DNA binding residues [nucleotide binding]
479433008181	dimerization interface [polypeptide binding]; other site
479433008182	AAA ATPase domain; Region: AAA_16; pfam13191
479433008183	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433008184	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433008185	DNA binding residues [nucleotide binding]
479433008186	dimerization interface [polypeptide binding]; other site
479433008187	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433008188	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433008189	dimer interface [polypeptide binding]; other site
479433008190	conserved gate region; other site
479433008191	putative PBP binding loops; other site
479433008192	ABC-ATPase subunit interface; other site
479433008193	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433008194	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433008195	dimer interface [polypeptide binding]; other site
479433008196	conserved gate region; other site
479433008197	putative PBP binding loops; other site
479433008198	ABC-ATPase subunit interface; other site
479433008199	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433008200	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
479433008201	RibD C-terminal domain; Region: RibD_C; cl17279
479433008202	RNA polymerase factor sigma-70; Validated; Region: PRK08241
479433008203	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433008204	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433008205	DNA binding residues [nucleotide binding]
479433008206	Transposase; Region: DEDD_Tnp_IS110; pfam01548
479433008207	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
479433008208	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
479433008209	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
479433008210	Trp docking motif [polypeptide binding]; other site
479433008211	active site
479433008212	PQQ-like domain; Region: PQQ_2; pfam13360
479433008213	Domain of unknown function (DUF4263); Region: DUF4263; pfam14082
479433008214	Baculovirus E66 occlusion-derived virus envelope protein; Region: Baculo_E66; cl17813
479433008215	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433008216	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433008217	putative sugar binding sites [chemical binding]; other site
479433008218	Q-X-W motif; other site
479433008219	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
479433008220	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
479433008221	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
479433008222	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
479433008223	Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256
479433008224	RHS Repeat; Region: RHS_repeat; cl11982
479433008225	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
479433008226	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
479433008227	protein-splicing catalytic site; other site
479433008228	thioester formation/cholesterol transfer; other site
479433008229	Pretoxin HINT domain; Region: PT-HINT; pfam07591
479433008230	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
479433008231	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
479433008232	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433008233	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
479433008234	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
479433008235	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
479433008236	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
479433008237	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433008238	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
479433008239	Walker A/P-loop; other site
479433008240	ATP binding site [chemical binding]; other site
479433008241	Q-loop/lid; other site
479433008242	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433008243	ABC transporter signature motif; other site
479433008244	Walker B; other site
479433008245	D-loop; other site
479433008246	H-loop/switch region; other site
479433008247	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433008248	Walker A/P-loop; other site
479433008249	ATP binding site [chemical binding]; other site
479433008250	Q-loop/lid; other site
479433008251	ABC transporter signature motif; other site
479433008252	Walker B; other site
479433008253	D-loop; other site
479433008254	H-loop/switch region; other site
479433008255	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
479433008256	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433008257	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
479433008258	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433008259	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
479433008260	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433008261	active site
479433008262	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433008263	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
479433008264	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433008265	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433008266	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433008267	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433008268	putative substrate translocation pore; other site
479433008269	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433008270	C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441
479433008271	lysozyme catalytic cleft [active]
479433008272	lysozyme catalytic site [active]
479433008273	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433008274	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433008275	putative sugar binding sites [chemical binding]; other site
479433008276	Q-X-W motif; other site
479433008277	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
479433008278	dimerization interface [polypeptide binding]; other site
479433008279	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
479433008280	amidase catalytic site [active]
479433008281	Zn binding residues [ion binding]; other site
479433008282	substrate binding site [chemical binding]; other site
479433008283	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
479433008284	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
479433008285	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
479433008286	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
479433008287	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433008288	FeS/SAM binding site; other site
479433008289	RNA polymerase factor sigma-70; Validated; Region: PRK08241
479433008290	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433008291	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433008292	DNA binding residues [nucleotide binding]
479433008293	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
479433008294	Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829
479433008295	active site
479433008296	putative catalytic site [active]
479433008297	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
479433008298	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433008299	putative NAD(P) binding site [chemical binding]; other site
479433008300	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
479433008301	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
479433008302	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433008303	catalytic residue [active]
479433008304	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
479433008305	Protein of unknown function (DUF664); Region: DUF664; pfam04978
479433008306	DinB superfamily; Region: DinB_2; pfam12867
479433008307	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
479433008308	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
479433008309	intersubunit interface [polypeptide binding]; other site
479433008310	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
479433008311	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
479433008312	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
479433008313	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
479433008314	ABC-ATPase subunit  interface; other site
479433008315	dimer interface [polypeptide binding]; other site
479433008316	putative PBP binding regions; other site
479433008317	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
479433008318	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
479433008319	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433008320	dimerization interface [polypeptide binding]; other site
479433008321	putative DNA binding site [nucleotide binding]; other site
479433008322	putative Zn2+ binding site [ion binding]; other site
479433008323	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
479433008324	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433008325	S-adenosylmethionine binding site [chemical binding]; other site
479433008326	CopC domain; Region: CopC; pfam04234
479433008327	Copper resistance protein D; Region: CopD; pfam05425
479433008328	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433008329	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433008330	active site
479433008331	catalytic tetrad [active]
479433008332	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
479433008333	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
479433008334	Walker A/P-loop; other site
479433008335	ATP binding site [chemical binding]; other site
479433008336	Q-loop/lid; other site
479433008337	ABC transporter signature motif; other site
479433008338	Walker B; other site
479433008339	D-loop; other site
479433008340	H-loop/switch region; other site
479433008341	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
479433008342	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
479433008343	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
479433008344	Ligand Binding Site [chemical binding]; other site
479433008345	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
479433008346	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
479433008347	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
479433008348	active site
479433008349	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433008350	sugar binding site [chemical binding]; other site
479433008351	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
479433008352	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433008353	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433008354	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433008355	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
479433008356	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
479433008357	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433008358	active site
479433008359	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433008360	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433008361	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
479433008362	dimerization interface [polypeptide binding]; other site
479433008363	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
479433008364	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
479433008365	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
479433008366	active site
479433008367	catalytic triad [active]
479433008368	oxyanion hole [active]
479433008369	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
479433008370	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433008371	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433008372	active site
479433008373	Predicted transcriptional regulators [Transcription]; Region: COG1695
479433008374	Transcriptional regulator PadR-like family; Region: PadR; cl17335
479433008375	hypothetical protein; Provisional; Region: PRK06847
479433008376	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
479433008377	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
479433008378	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
479433008379	conserved cys residue [active]
479433008380	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433008381	HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401
479433008382	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
479433008383	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433008384	putative NAD(P) binding site [chemical binding]; other site
479433008385	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433008386	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433008387	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
479433008388	dimerization interface [polypeptide binding]; other site
479433008389	substrate binding pocket [chemical binding]; other site
479433008390	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
479433008391	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
479433008392	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
479433008393	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
479433008394	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
479433008395	glycogen branching enzyme; Provisional; Region: PRK12313
479433008396	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
479433008397	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
479433008398	active site
479433008399	catalytic site [active]
479433008400	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
479433008401	Histidine kinase; Region: HisKA_3; pfam07730
479433008402	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433008403	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433008404	non-specific DNA binding site [nucleotide binding]; other site
479433008405	salt bridge; other site
479433008406	sequence-specific DNA binding site [nucleotide binding]; other site
479433008407	Condensation domain; Region: Condensation; pfam00668
479433008408	Condensation domain; Region: Condensation; pfam00668
479433008409	Condensation domain; Region: Condensation; pfam00668
479433008410	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433008411	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
479433008412	NAD(P) binding site [chemical binding]; other site
479433008413	active site
479433008414	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433008415	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
479433008416	Walker A/P-loop; other site
479433008417	ATP binding site [chemical binding]; other site
479433008418	Q-loop/lid; other site
479433008419	ABC transporter signature motif; other site
479433008420	Walker B; other site
479433008421	D-loop; other site
479433008422	H-loop/switch region; other site
479433008423	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
479433008424	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
479433008425	ABC-2 type transporter; Region: ABC2_membrane; cl17235
479433008426	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
479433008427	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
479433008428	active site
479433008429	TDP-binding site; other site
479433008430	acceptor substrate-binding pocket; other site
479433008431	Methyltransferase domain; Region: Methyltransf_31; pfam13847
479433008432	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433008433	S-adenosylmethionine binding site [chemical binding]; other site
479433008434	Protein of unknown function (DUF938); Region: DUF938; pfam06080
479433008435	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433008436	AMP-binding enzyme; Region: AMP-binding; pfam00501
479433008437	acyl-activating enzyme (AAE) consensus motif; other site
479433008438	AMP binding site [chemical binding]; other site
479433008439	active site
479433008440	CoA binding site [chemical binding]; other site
479433008441	Phosphopantetheine attachment site; Region: PP-binding; cl09936
479433008442	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
479433008443	active site
479433008444	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
479433008445	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
479433008446	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
479433008447	dimer interface [polypeptide binding]; other site
479433008448	active site
479433008449	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
479433008450	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
479433008451	dimer interface [polypeptide binding]; other site
479433008452	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
479433008453	active site
479433008454	Fe binding site [ion binding]; other site
479433008455	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
479433008456	Protein of unknown function (DUF3050); Region: DUF3050; pfam11251
479433008457	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
479433008458	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
479433008459	tetramer interface [polypeptide binding]; other site
479433008460	TPP-binding site [chemical binding]; other site
479433008461	heterodimer interface [polypeptide binding]; other site
479433008462	phosphorylation loop region [posttranslational modification]
479433008463	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
479433008464	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
479433008465	alpha subunit interface [polypeptide binding]; other site
479433008466	TPP binding site [chemical binding]; other site
479433008467	heterodimer interface [polypeptide binding]; other site
479433008468	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
479433008469	classical (c) SDRs; Region: SDR_c; cd05233
479433008470	NAD(P) binding site [chemical binding]; other site
479433008471	active site
479433008472	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433008473	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
479433008474	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433008475	acyl-activating enzyme (AAE) consensus motif; other site
479433008476	acyl-activating enzyme (AAE) consensus motif; other site
479433008477	active site
479433008478	AMP binding site [chemical binding]; other site
479433008479	CoA binding site [chemical binding]; other site
479433008480	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
479433008481	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
479433008482	active site
479433008483	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
479433008484	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
479433008485	active site
479433008486	substrate binding site [chemical binding]; other site
479433008487	FMN binding site [chemical binding]; other site
479433008488	putative catalytic residues [active]
479433008489	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
479433008490	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
479433008491	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433008492	homodimer interface [polypeptide binding]; other site
479433008493	catalytic residue [active]
479433008494	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
479433008495	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
479433008496	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
479433008497	active site
479433008498	catalytic triad [active]
479433008499	oxyanion hole [active]
479433008500	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
479433008501	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
479433008502	Spore germination protein; Region: Spore_permease; cl17796
479433008503	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433008504	putative substrate translocation pore; other site
479433008505	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433008506	putative substrate translocation pore; other site
479433008507	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
479433008508	active site clefts [active]
479433008509	zinc binding site [ion binding]; other site
479433008510	dimer interface [polypeptide binding]; other site
479433008511	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433008512	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433008513	WHG domain; Region: WHG; pfam13305
479433008514	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433008515	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433008516	active site
479433008517	ATP binding site [chemical binding]; other site
479433008518	substrate binding site [chemical binding]; other site
479433008519	activation loop (A-loop); other site
479433008520	Putative zinc-finger; Region: zf-HC2; pfam13490
479433008521	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
479433008522	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433008523	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433008524	DNA binding residues [nucleotide binding]
479433008525	Possible enoyl reductase; Region: MDR_enoyl_red; cd08244
479433008526	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433008527	putative NAD(P) binding site [chemical binding]; other site
479433008528	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433008529	classical (c) SDRs; Region: SDR_c; cd05233
479433008530	NAD(P) binding site [chemical binding]; other site
479433008531	active site
479433008532	Thioredoxin; Region: Thioredoxin_4; cl17273
479433008533	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
479433008534	active site
479433008535	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433008536	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
479433008537	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
479433008538	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
479433008539	Predicted deacetylase [General function prediction only]; Region: COG3233
479433008540	putative active site [active]
479433008541	putative Zn binding site [ion binding]; other site
479433008542	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
479433008543	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
479433008544	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433008545	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433008546	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433008547	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
479433008548	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
479433008549	Uncharacterized conserved protein [Function unknown]; Region: COG3391
479433008550	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
479433008551	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
479433008552	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433008553	S-adenosylmethionine binding site [chemical binding]; other site
479433008554	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
479433008555	dimer interface [polypeptide binding]; other site
479433008556	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433008557	HTH domain; Region: HTH_11; pfam08279
479433008558	WYL domain; Region: WYL; pfam13280
479433008559	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
479433008560	putative metal binding site [ion binding]; other site
479433008561	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
479433008562	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433008563	sugar binding site [chemical binding]; other site
479433008564	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433008565	sugar binding site [chemical binding]; other site
479433008566	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
479433008567	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
479433008568	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433008569	DNA-binding site [nucleotide binding]; DNA binding site
479433008570	FCD domain; Region: FCD; pfam07729
479433008571	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433008572	putative substrate translocation pore; other site
479433008573	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433008574	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
479433008575	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
479433008576	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
479433008577	active site
479433008578	metal binding site [ion binding]; metal-binding site
479433008579	Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399
479433008580	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
479433008581	Cupin; Region: Cupin_6; pfam12852
479433008582	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433008583	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
479433008584	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433008585	oxidoreductase; Provisional; Region: PRK06196
479433008586	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
479433008587	putative NAD(P) binding site [chemical binding]; other site
479433008588	active site
479433008589	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
479433008590	active site
479433008591	metal binding site [ion binding]; metal-binding site
479433008592	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
479433008593	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
479433008594	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
479433008595	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433008596	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
479433008597	dimerization interface [polypeptide binding]; other site
479433008598	substrate binding pocket [chemical binding]; other site
479433008599	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
479433008600	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
479433008601	substrate binding pocket [chemical binding]; other site
479433008602	chain length determination region; other site
479433008603	substrate-Mg2+ binding site; other site
479433008604	catalytic residues [active]
479433008605	aspartate-rich region 1; other site
479433008606	active site lid residues [active]
479433008607	aspartate-rich region 2; other site
479433008608	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
479433008609	Nitrate and nitrite sensing; Region: NIT; pfam08376
479433008610	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433008611	ATP binding site [chemical binding]; other site
479433008612	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433008613	Mg2+ binding site [ion binding]; other site
479433008614	G-X-G motif; other site
479433008615	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
479433008616	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
479433008617	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
479433008618	G1 box; other site
479433008619	GTP/Mg2+ binding site [chemical binding]; other site
479433008620	G2 box; other site
479433008621	Switch I region; other site
479433008622	G3 box; other site
479433008623	Switch II region; other site
479433008624	G4 box; other site
479433008625	G5 box; other site
479433008626	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
479433008627	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
479433008628	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
479433008629	TM-ABC transporter signature motif; other site
479433008630	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
479433008631	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
479433008632	TM-ABC transporter signature motif; other site
479433008633	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
479433008634	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
479433008635	Walker A/P-loop; other site
479433008636	ATP binding site [chemical binding]; other site
479433008637	Q-loop/lid; other site
479433008638	ABC transporter signature motif; other site
479433008639	Walker B; other site
479433008640	D-loop; other site
479433008641	H-loop/switch region; other site
479433008642	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
479433008643	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
479433008644	Walker A/P-loop; other site
479433008645	ATP binding site [chemical binding]; other site
479433008646	Q-loop/lid; other site
479433008647	ABC transporter signature motif; other site
479433008648	Walker B; other site
479433008649	D-loop; other site
479433008650	H-loop/switch region; other site
479433008651	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
479433008652	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433008653	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433008654	active site
479433008655	CoA binding site [chemical binding]; other site
479433008656	AMP binding site [chemical binding]; other site
479433008657	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433008658	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433008659	active site
479433008660	catalytic tetrad [active]
479433008661	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
479433008662	active site
479433008663	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
479433008664	Hemerythrin-like domain; Region: Hr-like; cd12108
479433008665	Fe binding site [ion binding]; other site
479433008666	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
479433008667	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433008668	dimerization interface [polypeptide binding]; other site
479433008669	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
479433008670	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433008671	dimerization interface [polypeptide binding]; other site
479433008672	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433008673	dimerization interface [polypeptide binding]; other site
479433008674	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433008675	dimerization interface [polypeptide binding]; other site
479433008676	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433008677	dimerization interface [polypeptide binding]; other site
479433008678	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433008679	dimerization interface [polypeptide binding]; other site
479433008680	bHLH-MYC and R2R3-MYB transcription factors N-terminal; Region: bHLH-MYC_N; pfam14215
479433008681	GAF domain; Region: GAF_2; pfam13185
479433008682	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433008683	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433008684	dimer interface [polypeptide binding]; other site
479433008685	phosphorylation site [posttranslational modification]
479433008686	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433008687	ATP binding site [chemical binding]; other site
479433008688	Mg2+ binding site [ion binding]; other site
479433008689	G-X-G motif; other site
479433008690	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
479433008691	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433008692	active site
479433008693	phosphorylation site [posttranslational modification]
479433008694	intermolecular recognition site; other site
479433008695	dimerization interface [polypeptide binding]; other site
479433008696	GAF domain; Region: GAF_3; pfam13492
479433008697	GAF domain; Region: GAF_2; pfam13185
479433008698	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
479433008699	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
479433008700	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
479433008701	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433008702	hypothetical protein; Provisional; Region: PRK06834
479433008703	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
479433008704	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
479433008705	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433008706	DNA-binding site [nucleotide binding]; DNA binding site
479433008707	UTRA domain; Region: UTRA; pfam07702
479433008708	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
479433008709	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
479433008710	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433008711	dimer interface [polypeptide binding]; other site
479433008712	conserved gate region; other site
479433008713	putative PBP binding loops; other site
479433008714	ABC-ATPase subunit interface; other site
479433008715	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
479433008716	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433008717	Walker A/P-loop; other site
479433008718	ATP binding site [chemical binding]; other site
479433008719	Q-loop/lid; other site
479433008720	ABC transporter signature motif; other site
479433008721	Walker B; other site
479433008722	D-loop; other site
479433008723	H-loop/switch region; other site
479433008724	TOBE domain; Region: TOBE_2; pfam08402
479433008725	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433008726	S-adenosylmethionine binding site [chemical binding]; other site
479433008727	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
479433008728	active site
479433008729	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
479433008730	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433008731	MarR family; Region: MarR_2; pfam12802
479433008732	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
479433008733	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
479433008734	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
479433008735	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
479433008736	PAS fold; Region: PAS_4; pfam08448
479433008737	putative active site [active]
479433008738	heme pocket [chemical binding]; other site
479433008739	PAS fold; Region: PAS_4; pfam08448
479433008740	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
479433008741	putative active site [active]
479433008742	heme pocket [chemical binding]; other site
479433008743	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
479433008744	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
479433008745	metal binding site [ion binding]; metal-binding site
479433008746	active site
479433008747	I-site; other site
479433008748	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
479433008749	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
479433008750	hypothetical protein; Provisional; Region: PRK08244
479433008751	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
479433008752	nucleoside/Zn binding site; other site
479433008753	dimer interface [polypeptide binding]; other site
479433008754	catalytic motif [active]
479433008755	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
479433008756	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
479433008757	putative ligand binding site [chemical binding]; other site
479433008758	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
479433008759	TM-ABC transporter signature motif; other site
479433008760	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
479433008761	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
479433008762	TM-ABC transporter signature motif; other site
479433008763	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433008764	Walker A/P-loop; other site
479433008765	ATP binding site [chemical binding]; other site
479433008766	ABC transporter; Region: ABC_tran; pfam00005
479433008767	Q-loop/lid; other site
479433008768	ABC transporter signature motif; other site
479433008769	Walker B; other site
479433008770	D-loop; other site
479433008771	H-loop/switch region; other site
479433008772	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433008773	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
479433008774	Walker A/P-loop; other site
479433008775	ATP binding site [chemical binding]; other site
479433008776	Q-loop/lid; other site
479433008777	ABC transporter signature motif; other site
479433008778	Walker B; other site
479433008779	D-loop; other site
479433008780	H-loop/switch region; other site
479433008781	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
479433008782	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
479433008783	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
479433008784	transmembrane helices; other site
479433008785	Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426
479433008786	polypeptide substrate binding site [polypeptide binding]; other site
479433008787	active site
479433008788	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
479433008789	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217
479433008790	FAD binding pocket [chemical binding]; other site
479433008791	FAD binding motif [chemical binding]; other site
479433008792	phosphate binding motif [ion binding]; other site
479433008793	beta-alpha-beta structure motif; other site
479433008794	NAD binding pocket [chemical binding]; other site
479433008795	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
479433008796	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
479433008797	Moco binding site; other site
479433008798	metal coordination site [ion binding]; other site
479433008799	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433008800	Cytochrome P450; Region: p450; cl12078
479433008801	acyl-coenzyme A oxidase; Region: PLN02636
479433008802	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433008803	active site
479433008804	Putative esterase; Region: Esterase; pfam00756
479433008805	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433008806	NADH(P)-binding; Region: NAD_binding_10; pfam13460
479433008807	NAD(P) binding site [chemical binding]; other site
479433008808	active site
479433008809	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433008810	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433008811	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433008812	DNA binding residues [nucleotide binding]
479433008813	pyruvate dehydrogenase; Provisional; Region: PRK06546
479433008814	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
479433008815	PYR/PP interface [polypeptide binding]; other site
479433008816	dimer interface [polypeptide binding]; other site
479433008817	tetramer interface [polypeptide binding]; other site
479433008818	TPP binding site [chemical binding]; other site
479433008819	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
479433008820	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
479433008821	TPP-binding site [chemical binding]; other site
479433008822	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
479433008823	peptidase domain interface [polypeptide binding]; other site
479433008824	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
479433008825	active site
479433008826	catalytic triad [active]
479433008827	calcium binding site [ion binding]; other site
479433008828	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
479433008829	dimerization interface [polypeptide binding]; other site
479433008830	putative DNA binding site [nucleotide binding]; other site
479433008831	putative Zn2+ binding site [ion binding]; other site
479433008832	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
479433008833	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433008834	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433008835	DNA binding residues [nucleotide binding]
479433008836	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
479433008837	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
479433008838	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433008839	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433008840	ATP binding site [chemical binding]; other site
479433008841	Mg2+ binding site [ion binding]; other site
479433008842	G-X-G motif; other site
479433008843	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
479433008844	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
479433008845	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
479433008846	substrate binding pocket [chemical binding]; other site
479433008847	membrane-bound complex binding site; other site
479433008848	hinge residues; other site
479433008849	Putative zinc-finger; Region: zf-HC2; pfam13490
479433008850	Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426
479433008851	polypeptide substrate binding site [polypeptide binding]; other site
479433008852	active site
479433008853	Methyltransferase domain; Region: Methyltransf_12; pfam08242
479433008854	S-adenosylmethionine binding site [chemical binding]; other site
479433008855	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
479433008856	Class I aldolases; Region: Aldolase_Class_I; cl17187
479433008857	catalytic residue [active]
479433008858	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
479433008859	DNA binding residues [nucleotide binding]
479433008860	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433008861	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433008862	DNA binding residues [nucleotide binding]
479433008863	dimerization interface [polypeptide binding]; other site
479433008864	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
479433008865	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433008866	sugar binding site [chemical binding]; other site
479433008867	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
479433008868	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433008869	sugar binding site [chemical binding]; other site
479433008870	CARDB; Region: CARDB; pfam07705
479433008871	CARDB; Region: CARDB; pfam07705
479433008872	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
479433008873	putative metal binding site [ion binding]; other site
479433008874	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
479433008875	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433008876	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
479433008877	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433008878	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433008879	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
479433008880	anti sigma factor interaction site; other site
479433008881	regulatory phosphorylation site [posttranslational modification]; other site
479433008882	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
479433008883	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433008884	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
479433008885	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433008886	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
479433008887	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433008888	DNA binding residues [nucleotide binding]
479433008889	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433008890	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433008891	active site
479433008892	ATP binding site [chemical binding]; other site
479433008893	substrate binding site [chemical binding]; other site
479433008894	activation loop (A-loop); other site
479433008895	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
479433008896	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
479433008897	active site
479433008898	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
479433008899	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
479433008900	active site
479433008901	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
479433008902	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
479433008903	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
479433008904	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
479433008905	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
479433008906	active site
479433008907	FMN binding site [chemical binding]; other site
479433008908	substrate binding site [chemical binding]; other site
479433008909	3Fe-4S cluster binding site [ion binding]; other site
479433008910	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
479433008911	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
479433008912	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
479433008913	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
479433008914	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
479433008915	active site
479433008916	metal binding site [ion binding]; metal-binding site
479433008917	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
479433008918	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433008919	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
479433008920	active site
479433008921	catalytic triad [active]
479433008922	calcium binding site [ion binding]; other site
479433008923	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
479433008924	Kelch domain; Region: Kelch; smart00612
479433008925	Kelch motif; Region: Kelch_1; pfam01344
479433008926	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
479433008927	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
479433008928	putative DNA binding site [nucleotide binding]; other site
479433008929	catalytic residue [active]
479433008930	putative H2TH interface [polypeptide binding]; other site
479433008931	putative catalytic residues [active]
479433008932	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
479433008933	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
479433008934	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
479433008935	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433008936	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433008937	Condensation domain; Region: Condensation; pfam00668
479433008938	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
479433008939	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
479433008940	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
479433008941	acyl-activating enzyme (AAE) consensus motif; other site
479433008942	AMP binding site [chemical binding]; other site
479433008943	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433008944	Condensation domain; Region: Condensation; pfam00668
479433008945	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
479433008946	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
479433008947	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433008948	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433008949	Cytochrome P450; Region: p450; cl12078
479433008950	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
479433008951	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433008952	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
479433008953	B12 binding site [chemical binding]; other site
479433008954	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
479433008955	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433008956	FeS/SAM binding site; other site
479433008957	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
479433008958	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
479433008959	acyl-activating enzyme (AAE) consensus motif; other site
479433008960	AMP binding site [chemical binding]; other site
479433008961	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433008962	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433008963	Cytochrome P450; Region: p450; cl12078
479433008964	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
479433008965	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
479433008966	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
479433008967	acyl-activating enzyme (AAE) consensus motif; other site
479433008968	AMP binding site [chemical binding]; other site
479433008969	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433008970	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
479433008971	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433008972	Condensation domain; Region: Condensation; pfam00668
479433008973	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
479433008974	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
479433008975	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
479433008976	acyl-activating enzyme (AAE) consensus motif; other site
479433008977	AMP binding site [chemical binding]; other site
479433008978	Condensation domain; Region: Condensation; pfam00668
479433008979	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
479433008980	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
479433008981	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433008982	active site
479433008983	CoA binding site [chemical binding]; other site
479433008984	AMP binding site [chemical binding]; other site
479433008985	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433008986	hypothetical protein; Validated; Region: PRK07581
479433008987	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
479433008988	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433008989	Condensation domain; Region: Condensation; pfam00668
479433008990	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
479433008991	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
479433008992	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433008993	AMP-binding enzyme; Region: AMP-binding; pfam00501
479433008994	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433008995	active site
479433008996	CoA binding site [chemical binding]; other site
479433008997	AMP binding site [chemical binding]; other site
479433008998	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433008999	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433009000	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
479433009001	acyl-activating enzyme (AAE) consensus motif; other site
479433009002	AMP binding site [chemical binding]; other site
479433009003	active site
479433009004	CoA binding site [chemical binding]; other site
479433009005	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
479433009006	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433009007	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433009008	putative sugar binding sites [chemical binding]; other site
479433009009	Q-X-W motif; other site
479433009010	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433009011	Cytochrome P450; Region: p450; cl12078
479433009012	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
479433009013	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
479433009014	acyl-activating enzyme (AAE) consensus motif; other site
479433009015	AMP binding site [chemical binding]; other site
479433009016	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433009017	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
479433009018	acyl-activating enzyme (AAE) consensus motif; other site
479433009019	AMP binding site [chemical binding]; other site
479433009020	Thioesterase domain; Region: Thioesterase; pfam00975
479433009021	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
479433009022	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
479433009023	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
479433009024	Fatty acid desaturase; Region: FA_desaturase; pfam00487
479433009025	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
479433009026	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
479433009027	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
479433009028	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
479433009029	Thioesterase domain; Region: Thioesterase; pfam00975
479433009030	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
479433009031	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433009032	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433009033	capreomycidine synthase; Region: viomycin_VioD; TIGR03947
479433009034	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
479433009035	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433009036	homodimer interface [polypeptide binding]; other site
479433009037	catalytic residue [active]
479433009038	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433009039	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433009040	DNA binding residues [nucleotide binding]
479433009041	dimerization interface [polypeptide binding]; other site
479433009042	Dienelactone hydrolase family; Region: DLH; pfam01738
479433009043	Condensation domain; Region: Condensation; pfam00668
479433009044	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
479433009045	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
479433009046	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
479433009047	acyl-activating enzyme (AAE) consensus motif; other site
479433009048	AMP binding site [chemical binding]; other site
479433009049	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433009050	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
479433009051	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
479433009052	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433009053	homodimer interface [polypeptide binding]; other site
479433009054	catalytic residue [active]
479433009055	arginine beta-hydroxylase, Fe(II)/alpha-ketoglutarate-dependent; Region: viomycin_VioC; TIGR03946
479433009056	substrate binding pocket [chemical binding]; other site
479433009057	active site
479433009058	iron coordination sites [ion binding]; other site
479433009059	hypothetical protein; Provisional; Region: PRK07550
479433009060	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
479433009061	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433009062	homodimer interface [polypeptide binding]; other site
479433009063	catalytic residue [active]
479433009064	acyl-CoA synthetase; Validated; Region: PRK05850
479433009065	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
479433009066	acyl-activating enzyme (AAE) consensus motif; other site
479433009067	active site
479433009068	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433009069	Condensation domain; Region: Condensation; pfam00668
479433009070	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
479433009071	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
479433009072	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
479433009073	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
479433009074	acyl-activating enzyme (AAE) consensus motif; other site
479433009075	AMP binding site [chemical binding]; other site
479433009076	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433009077	Condensation domain; Region: Condensation; pfam00668
479433009078	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
479433009079	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
479433009080	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
479433009081	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
479433009082	active site
479433009083	Low affinity iron permease; Region: Iron_permease; cl12096
479433009084	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
479433009085	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433009086	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
479433009087	Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082
479433009088	Ca binding site [ion binding]; other site
479433009089	Ca binding site (active) [ion binding]; other site
479433009090	ligand binding site [chemical binding]; other site
479433009091	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433009092	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
479433009093	Interdomain contacts; other site
479433009094	Cytokine receptor motif; other site
479433009095	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
479433009096	Interdomain contacts; other site
479433009097	Cytokine receptor motif; other site
479433009098	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
479433009099	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
479433009100	PRC-barrel domain; Region: PRC; pfam05239
479433009101	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
479433009102	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
479433009103	Beta-lactamase; Region: Beta-lactamase; pfam00144
479433009104	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
479433009105	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
479433009106	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433009107	Phosphopantetheine attachment site; Region: PP-binding; cl09936
479433009108	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
479433009109	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
479433009110	active site
479433009111	Acyl transferase domain; Region: Acyl_transf_1; cl08282
479433009112	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
479433009113	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
479433009114	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
479433009115	phosphate binding site [ion binding]; other site
479433009116	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
479433009117	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
479433009118	phosphate binding site [ion binding]; other site
479433009119	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
479433009120	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
479433009121	active site
479433009122	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
479433009123	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
479433009124	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
479433009125	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
479433009126	putative NADP binding site [chemical binding]; other site
479433009127	active site
479433009128	Methyltransferase domain; Region: Methyltransf_23; pfam13489
479433009129	Methyltransferase domain; Region: Methyltransf_12; pfam08242
479433009130	Predicted transcriptional regulators [Transcription]; Region: COG1695
479433009131	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
479433009132	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
479433009133	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
479433009134	FAD binding pocket [chemical binding]; other site
479433009135	FAD binding motif [chemical binding]; other site
479433009136	phosphate binding motif [ion binding]; other site
479433009137	NAD binding pocket [chemical binding]; other site
479433009138	Transcription factor WhiB; Region: Whib; pfam02467
479433009139	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
479433009140	nucleoside/Zn binding site; other site
479433009141	dimer interface [polypeptide binding]; other site
479433009142	catalytic motif [active]
479433009143	hydroperoxidase II; Provisional; Region: katE; PRK11249
479433009144	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
479433009145	tetramer interface [polypeptide binding]; other site
479433009146	heme binding pocket [chemical binding]; other site
479433009147	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
479433009148	conserved cys residue [active]
479433009149	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
479433009150	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433009151	active site
479433009152	phosphorylation site [posttranslational modification]
479433009153	intermolecular recognition site; other site
479433009154	dimerization interface [polypeptide binding]; other site
479433009155	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
479433009156	CHASE3 domain; Region: CHASE3; pfam05227
479433009157	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433009158	dimerization interface [polypeptide binding]; other site
479433009159	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433009160	dimer interface [polypeptide binding]; other site
479433009161	phosphorylation site [posttranslational modification]
479433009162	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433009163	ATP binding site [chemical binding]; other site
479433009164	Mg2+ binding site [ion binding]; other site
479433009165	G-X-G motif; other site
479433009166	Response regulator receiver domain; Region: Response_reg; pfam00072
479433009167	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433009168	active site
479433009169	phosphorylation site [posttranslational modification]
479433009170	intermolecular recognition site; other site
479433009171	dimerization interface [polypeptide binding]; other site
479433009172	mycothione reductase; Reviewed; Region: PRK07846
479433009173	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
479433009174	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
479433009175	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
479433009176	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
479433009177	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
479433009178	active site
479433009179	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433009180	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433009181	DNA binding site [nucleotide binding]
479433009182	domain linker motif; other site
479433009183	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
479433009184	putative dimerization interface [polypeptide binding]; other site
479433009185	putative ligand binding site [chemical binding]; other site
479433009186	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433009187	sugar binding site [chemical binding]; other site
479433009188	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433009189	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433009190	sugar binding site [chemical binding]; other site
479433009191	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433009192	sugar binding site [chemical binding]; other site
479433009193	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433009194	sugar binding site [chemical binding]; other site
479433009195	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
479433009196	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
479433009197	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
479433009198	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
479433009199	Transposase; Region: DEDD_Tnp_IS110; pfam01548
479433009200	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
479433009201	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
479433009202	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
479433009203	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
479433009204	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
479433009205	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
479433009206	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433009207	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
479433009208	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
479433009209	CoenzymeA binding site [chemical binding]; other site
479433009210	subunit interaction site [polypeptide binding]; other site
479433009211	PHB binding site; other site
479433009212	acyl-CoA synthetase; Validated; Region: PRK06188
479433009213	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433009214	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
479433009215	acyl-activating enzyme (AAE) consensus motif; other site
479433009216	acyl-activating enzyme (AAE) consensus motif; other site
479433009217	putative AMP binding site [chemical binding]; other site
479433009218	putative active site [active]
479433009219	putative CoA binding site [chemical binding]; other site
479433009220	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433009221	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433009222	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433009223	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
479433009224	dinuclear metal binding motif [ion binding]; other site
479433009225	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
479433009226	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433009227	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433009228	acyl-activating enzyme (AAE) consensus motif; other site
479433009229	acyl-activating enzyme (AAE) consensus motif; other site
479433009230	AMP binding site [chemical binding]; other site
479433009231	active site
479433009232	CoA binding site [chemical binding]; other site
479433009233	acyl carrier protein; Provisional; Region: PRK07081
479433009234	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
479433009235	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433009236	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
479433009237	AMP-binding enzyme; Region: AMP-binding; pfam00501
479433009238	acyl-activating enzyme (AAE) consensus motif; other site
479433009239	active site
479433009240	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433009241	AMP-binding enzyme; Region: AMP-binding; pfam00501
479433009242	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433009243	acyl-activating enzyme (AAE) consensus motif; other site
479433009244	AMP binding site [chemical binding]; other site
479433009245	active site
479433009246	CoA binding site [chemical binding]; other site
479433009247	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
479433009248	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433009249	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
479433009250	phosphorylation site [posttranslational modification]
479433009251	intermolecular recognition site; other site
479433009252	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433009253	DNA binding residues [nucleotide binding]
479433009254	dimerization interface [polypeptide binding]; other site
479433009255	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
479433009256	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
479433009257	kynureninase; Region: kynureninase; TIGR01814
479433009258	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433009259	catalytic residue [active]
479433009260	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
479433009261	active site
479433009262	short chain dehydrogenase; Validated; Region: PRK08324
479433009263	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
479433009264	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433009265	NAD(P) binding site [chemical binding]; other site
479433009266	active site
479433009267	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
479433009268	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
479433009269	RHS Repeat; Region: RHS_repeat; cl11982
479433009270	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
479433009271	RHS Repeat; Region: RHS_repeat; pfam05593
479433009272	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
479433009273	RHS Repeat; Region: RHS_repeat; pfam05593
479433009274	RHS Repeat; Region: RHS_repeat; pfam05593
479433009275	RHS Repeat; Region: RHS_repeat; cl11982
479433009276	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
479433009277	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
479433009278	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
479433009279	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
479433009280	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
479433009281	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
479433009282	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
479433009283	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433009284	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433009285	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433009286	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
479433009287	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
479433009288	Moco binding site; other site
479433009289	metal coordination site [ion binding]; other site
479433009290	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433009291	Cytochrome P450; Region: p450; cl12078
479433009292	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
479433009293	substrate binding pocket [chemical binding]; other site
479433009294	substrate-Mg2+ binding site; other site
479433009295	aspartate-rich region 1; other site
479433009296	aspartate-rich region 2; other site
479433009297	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433009298	Coenzyme A binding pocket [chemical binding]; other site
479433009299	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
479433009300	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433009301	Cytochrome P450; Region: p450; cl12078
479433009302	Protein of unknown function (DUF2781); Region: DUF2781; pfam10914
479433009303	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
479433009304	Protein of unknown function (DUF4243); Region: DUF4243; pfam14027
479433009305	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
479433009306	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
479433009307	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
479433009308	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
479433009309	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
479433009310	carboxyltransferase (CT) interaction site; other site
479433009311	biotinylation site [posttranslational modification]; other site
479433009312	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433009313	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433009314	active site
479433009315	phosphorylation site [posttranslational modification]
479433009316	intermolecular recognition site; other site
479433009317	dimerization interface [polypeptide binding]; other site
479433009318	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433009319	DNA binding site [nucleotide binding]
479433009320	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
479433009321	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
479433009322	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
479433009323	hypothetical protein; Provisional; Region: PRK06834
479433009324	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
479433009325	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
479433009326	Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673
479433009327	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
479433009328	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
479433009329	dimer interface [polypeptide binding]; other site
479433009330	active site
479433009331	Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein; Region: CLF; cd00832
479433009332	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
479433009333	active site
479433009334	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433009335	Polyketide ketoreductase, classical (c) SDR; Region: PKR_SDR_c; cd08945
479433009336	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
479433009337	NAD(P) binding site [chemical binding]; other site
479433009338	homodimer interface [polypeptide binding]; other site
479433009339	substrate binding site [chemical binding]; other site
479433009340	active site
479433009341	N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus  OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861
479433009342	putative hydrophobic ligand binding site [chemical binding]; other site
479433009343	N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus  OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861
479433009344	putative hydrophobic ligand binding site [chemical binding]; other site
479433009345	FAD binding domain; Region: FAD_binding_3; pfam01494
479433009346	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
479433009347	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
479433009348	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
479433009349	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
479433009350	hydrophobic ligand binding site; other site
479433009351	MarR family; Region: MarR; pfam01047
479433009352	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433009353	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433009354	putative substrate translocation pore; other site
479433009355	Cupin domain; Region: Cupin_2; pfam07883
479433009356	Hemerythrin-like domain; Region: Hr-like; cd12108
479433009357	Fe binding site [ion binding]; other site
479433009358	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
479433009359	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
479433009360	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433009361	NAD(P) binding site [chemical binding]; other site
479433009362	active site
479433009363	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
479433009364	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
479433009365	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
479433009366	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
479433009367	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433009368	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
479433009369	classical (c) SDRs; Region: SDR_c; cd05233
479433009370	NAD(P) binding site [chemical binding]; other site
479433009371	active site
479433009372	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433009373	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433009374	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433009375	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433009376	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
479433009377	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433009378	Walker A/P-loop; other site
479433009379	ATP binding site [chemical binding]; other site
479433009380	Q-loop/lid; other site
479433009381	ABC transporter signature motif; other site
479433009382	Walker B; other site
479433009383	D-loop; other site
479433009384	H-loop/switch region; other site
479433009385	CopC domain; Region: CopC; pfam04234
479433009386	Copper resistance protein D; Region: CopD; cl00563
479433009387	Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829
479433009388	active site
479433009389	putative catalytic site [active]
479433009390	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
479433009391	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
479433009392	putative dimer interface [polypeptide binding]; other site
479433009393	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433009394	SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833
479433009395	active site
479433009396	catalytic triad [active]
479433009397	oxyanion hole [active]
479433009398	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433009399	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433009400	putative sugar binding sites [chemical binding]; other site
479433009401	Q-X-W motif; other site
479433009402	Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057
479433009403	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433009404	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433009405	putative sugar binding sites [chemical binding]; other site
479433009406	Q-X-W motif; other site
479433009407	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663
479433009408	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433009409	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433009410	putative sugar binding sites [chemical binding]; other site
479433009411	Q-X-W motif; other site
479433009412	Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579
479433009413	putative ligand binding site [chemical binding]; other site
479433009414	putative catalytic site [active]
479433009415	Condensation domain; Region: Condensation; pfam00668
479433009416	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
479433009417	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
479433009418	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
479433009419	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433009420	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433009421	DNA binding site [nucleotide binding]
479433009422	domain linker motif; other site
479433009423	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
479433009424	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433009425	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433009426	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433009427	dimer interface [polypeptide binding]; other site
479433009428	conserved gate region; other site
479433009429	putative PBP binding loops; other site
479433009430	ABC-ATPase subunit interface; other site
479433009431	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433009432	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433009433	dimer interface [polypeptide binding]; other site
479433009434	conserved gate region; other site
479433009435	putative PBP binding loops; other site
479433009436	ABC-ATPase subunit interface; other site
479433009437	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
479433009438	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
479433009439	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
479433009440	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
479433009441	Cellulose binding domain; Region: CBM_2; pfam00553
479433009442	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
479433009443	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
479433009444	NAD(P) binding site [chemical binding]; other site
479433009445	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433009446	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433009447	DNA binding site [nucleotide binding]
479433009448	domain linker motif; other site
479433009449	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
479433009450	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
479433009451	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
479433009452	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433009453	dimer interface [polypeptide binding]; other site
479433009454	conserved gate region; other site
479433009455	putative PBP binding loops; other site
479433009456	ABC-ATPase subunit interface; other site
479433009457	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433009458	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433009459	dimer interface [polypeptide binding]; other site
479433009460	conserved gate region; other site
479433009461	putative PBP binding loops; other site
479433009462	ABC-ATPase subunit interface; other site
479433009463	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
479433009464	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
479433009465	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
479433009466	inhibitor binding site; inhibition site
479433009467	active site
479433009468	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433009469	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433009470	DNA binding site [nucleotide binding]
479433009471	domain linker motif; other site
479433009472	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433009473	dimerization interface [polypeptide binding]; other site
479433009474	ligand binding site [chemical binding]; other site
479433009475	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
479433009476	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
479433009477	Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302
479433009478	Cellulose binding domain; Region: CBM_2; pfam00553
479433009479	Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011
479433009480	Cellulose binding domain; Region: CBM_2; pfam00553
479433009481	SnoaL-like domain; Region: SnoaL_2; pfam12680
479433009482	Predicted membrane protein [Function unknown]; Region: COG2259
479433009483	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
479433009484	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
479433009485	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433009486	S-adenosylmethionine binding site [chemical binding]; other site
479433009487	AAA ATPase domain; Region: AAA_16; pfam13191
479433009488	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433009489	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433009490	DNA binding residues [nucleotide binding]
479433009491	dimerization interface [polypeptide binding]; other site
479433009492	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
479433009493	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433009494	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433009495	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
479433009496	DNA binding residues [nucleotide binding]
479433009497	dimerization interface [polypeptide binding]; other site
479433009498	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
479433009499	active site
479433009500	catalytic triad [active]
479433009501	oxyanion hole [active]
479433009502	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433009503	MarR family; Region: MarR_2; pfam12802
479433009504	AAA ATPase domain; Region: AAA_16; pfam13191
479433009505	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
479433009506	DNA binding residues [nucleotide binding]
479433009507	Transcription factor WhiB; Region: Whib; pfam02467
479433009508	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
479433009509	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
479433009510	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
479433009511	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433009512	Cupin domain; Region: Cupin_2; pfam07883
479433009513	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433009514	short chain dehydrogenase; Provisional; Region: PRK06523
479433009515	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433009516	NAD(P) binding site [chemical binding]; other site
479433009517	active site
479433009518	Lipase (class 2); Region: Lipase_2; pfam01674
479433009519	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433009520	AAA ATPase domain; Region: AAA_16; pfam13191
479433009521	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433009522	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433009523	DNA binding residues [nucleotide binding]
479433009524	dimerization interface [polypeptide binding]; other site
479433009525	AAA ATPase domain; Region: AAA_16; pfam13191
479433009526	AAA domain; Region: AAA_22; pfam13401
479433009527	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433009528	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433009529	DNA binding residues [nucleotide binding]
479433009530	dimerization interface [polypeptide binding]; other site
479433009531	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
479433009532	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433009533	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433009534	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
479433009535	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433009536	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
479433009537	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
479433009538	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
479433009539	active site
479433009540	catalytic triad [active]
479433009541	calcium binding site [ion binding]; other site
479433009542	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
479433009543	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
479433009544	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
479433009545	Zn2+ binding site [ion binding]; other site
479433009546	Mg2+ binding site [ion binding]; other site
479433009547	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433009548	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433009549	DNA binding residues [nucleotide binding]
479433009550	dimerization interface [polypeptide binding]; other site
479433009551	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
479433009552	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
479433009553	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
479433009554	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
479433009555	heme binding pocket [chemical binding]; other site
479433009556	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433009557	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433009558	binding surface
479433009559	TPR motif; other site
479433009560	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433009561	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
479433009562	HIT family signature motif; other site
479433009563	catalytic residue [active]
479433009564	Domain of unknown function (DUF4184); Region: DUF4184; pfam13803
479433009565	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
479433009566	SnoaL-like domain; Region: SnoaL_3; pfam13474
479433009567	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
479433009568	MDMPI C-terminal domain; Region: MDMPI_C; pfam07398
479433009569	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433009570	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433009571	putative substrate translocation pore; other site
479433009572	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433009573	putative substrate translocation pore; other site
479433009574	RNA polymerase factor sigma-70; Validated; Region: PRK08241
479433009575	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433009576	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433009577	DNA binding residues [nucleotide binding]
479433009578	TIGR03086 family protein; Region: TIGR03086
479433009579	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
479433009580	classical (c) SDRs; Region: SDR_c; cd05233
479433009581	NAD(P) binding site [chemical binding]; other site
479433009582	active site
479433009583	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
479433009584	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
479433009585	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
479433009586	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
479433009587	DNA binding residues [nucleotide binding]
479433009588	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433009589	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433009590	active site
479433009591	phosphorylation site [posttranslational modification]
479433009592	intermolecular recognition site; other site
479433009593	dimerization interface [polypeptide binding]; other site
479433009594	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433009595	DNA binding residues [nucleotide binding]
479433009596	dimerization interface [polypeptide binding]; other site
479433009597	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433009598	Histidine kinase; Region: HisKA_3; pfam07730
479433009599	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433009600	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
479433009601	Flavoprotein; Region: Flavoprotein; pfam02441
479433009602	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
479433009603	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
479433009604	MOSC domain; Region: MOSC; pfam03473
479433009605	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433009606	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433009607	Epoxide hydrolase N terminus; Region: EHN; pfam06441
479433009608	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433009609	von Willebrand factor type D domain; Region: VWD; cl02516
479433009610	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
479433009611	putative hydrophobic ligand binding site [chemical binding]; other site
479433009612	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
479433009613	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433009614	DNA-binding site [nucleotide binding]; DNA binding site
479433009615	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
479433009616	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433009617	homodimer interface [polypeptide binding]; other site
479433009618	catalytic residue [active]
479433009619	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
479433009620	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
479433009621	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
479433009622	Glutamine amidotransferase class-I; Region: GATase; pfam00117
479433009623	glutamine binding [chemical binding]; other site
479433009624	catalytic triad [active]
479433009625	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
479433009626	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433009627	acyl-activating enzyme (AAE) consensus motif; other site
479433009628	active site
479433009629	AMP binding site [chemical binding]; other site
479433009630	CoA binding site [chemical binding]; other site
479433009631	Prephenate dehydratase; Region: PDT; pfam00800
479433009632	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
479433009633	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
479433009634	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
479433009635	active site
479433009636	B3/4 domain; Region: B3_4; pfam03483
479433009637	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
479433009638	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433009639	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433009640	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433009641	tryptophan synthase subunit beta; Reviewed; Region: PRK12391
479433009642	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
479433009643	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433009644	catalytic residue [active]
479433009645	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
479433009646	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
479433009647	Cupin domain; Region: Cupin_2; pfam07883
479433009648	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
479433009649	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
479433009650	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433009651	DNA-binding site [nucleotide binding]; DNA binding site
479433009652	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
479433009653	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433009654	homodimer interface [polypeptide binding]; other site
479433009655	catalytic residue [active]
479433009656	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
479433009657	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433009658	DNA-binding site [nucleotide binding]; DNA binding site
479433009659	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
479433009660	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433009661	homodimer interface [polypeptide binding]; other site
479433009662	catalytic residue [active]
479433009663	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433009664	salt bridge; other site
479433009665	non-specific DNA binding site [nucleotide binding]; other site
479433009666	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433009667	sequence-specific DNA binding site [nucleotide binding]; other site
479433009668	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433009669	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433009670	active site
479433009671	catalytic tetrad [active]
479433009672	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
479433009673	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
479433009674	active site
479433009675	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433009676	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433009677	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
479433009678	sugar binding site [chemical binding]; other site
479433009679	glycosyl hydrolase 64 family; Region: GH64-like; cd09214
479433009680	substrate binding pocket [chemical binding]; other site
479433009681	catalytic residues [active]
479433009682	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
479433009683	DNA binding site [nucleotide binding]
479433009684	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433009685	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
479433009686	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
479433009687	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
479433009688	YcaO-like family; Region: YcaO; pfam02624
479433009689	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
479433009690	NADPH bind site [chemical binding]; other site
479433009691	putative FMN binding site [chemical binding]; other site
479433009692	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
479433009693	SpaB C-terminal domain; Region: SpaB_C; pfam14028
479433009694	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
479433009695	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709
479433009696	Peptidase family M50; Region: Peptidase_M50; pfam02163
479433009697	putative substrate binding region [chemical binding]; other site
479433009698	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433009699	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
479433009700	Walker A/P-loop; other site
479433009701	ATP binding site [chemical binding]; other site
479433009702	Q-loop/lid; other site
479433009703	ABC transporter signature motif; other site
479433009704	Walker B; other site
479433009705	D-loop; other site
479433009706	H-loop/switch region; other site
479433009707	ABC-2 type transporter; Region: ABC2_membrane; cl17235
479433009708	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
479433009709	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
479433009710	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
479433009711	YcaO-like family; Region: YcaO; pfam02624
479433009712	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
479433009713	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
479433009714	metal binding site [ion binding]; metal-binding site
479433009715	putative dimer interface [polypeptide binding]; other site
479433009716	Transposase domain (DUF772); Region: DUF772; pfam05598
479433009717	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
479433009718	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
479433009719	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
479433009720	active site
479433009721	catalytic site [active]
479433009722	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
479433009723	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433009724	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433009725	dimer interface [polypeptide binding]; other site
479433009726	conserved gate region; other site
479433009727	putative PBP binding loops; other site
479433009728	ABC-ATPase subunit interface; other site
479433009729	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433009730	dimer interface [polypeptide binding]; other site
479433009731	conserved gate region; other site
479433009732	putative PBP binding loops; other site
479433009733	ABC-ATPase subunit interface; other site
479433009734	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433009735	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433009736	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433009737	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433009738	DNA binding site [nucleotide binding]
479433009739	domain linker motif; other site
479433009740	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
479433009741	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433009742	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433009743	DNA binding site [nucleotide binding]
479433009744	domain linker motif; other site
479433009745	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
479433009746	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
479433009747	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
479433009748	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433009749	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
479433009750	putative metal binding site [ion binding]; other site
479433009751	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
479433009752	putative metal binding site [ion binding]; other site
479433009753	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
479433009754	putative metal binding site [ion binding]; other site
479433009755	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
479433009756	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
479433009757	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
479433009758	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
479433009759	active site
479433009760	catalytic site [active]
479433009761	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
479433009762	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
479433009763	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433009764	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433009765	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433009766	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
479433009767	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
479433009768	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
479433009769	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
479433009770	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
479433009771	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
479433009772	Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029
479433009773	Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029
479433009774	Beta-galactosidase, domain 3; Region: BetaGal_dom3; pfam13363
479433009775	Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364
479433009776	Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364
479433009777	NPCBM/NEW2 domain; Region: NPCBM; pfam08305
479433009778	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
479433009779	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433009780	sugar binding site [chemical binding]; other site
479433009781	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433009782	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433009783	DNA binding site [nucleotide binding]
479433009784	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
479433009785	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
479433009786	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
479433009787	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433009788	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433009789	putative sugar binding sites [chemical binding]; other site
479433009790	Q-X-W motif; other site
479433009791	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
479433009792	aromatic chitin/cellulose binding site residues [chemical binding]; other site
479433009793	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
479433009794	active site
479433009795	Cellulose binding domain; Region: CBM_2; pfam00553
479433009796	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
479433009797	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433009798	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
479433009799	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433009800	dimer interface [polypeptide binding]; other site
479433009801	conserved gate region; other site
479433009802	putative PBP binding loops; other site
479433009803	ABC-ATPase subunit interface; other site
479433009804	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433009805	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433009806	dimer interface [polypeptide binding]; other site
479433009807	conserved gate region; other site
479433009808	putative PBP binding loops; other site
479433009809	ABC-ATPase subunit interface; other site
479433009810	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
479433009811	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
479433009812	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
479433009813	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433009814	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433009815	DNA binding site [nucleotide binding]
479433009816	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433009817	ligand binding site [chemical binding]; other site
479433009818	dimerization interface [polypeptide binding]; other site
479433009819	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
479433009820	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
479433009821	active site
479433009822	homotetramer interface [polypeptide binding]; other site
479433009823	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
479433009824	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
479433009825	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
479433009826	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
479433009827	urea carboxylase; Region: urea_carbox; TIGR02712
479433009828	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
479433009829	ATP-grasp domain; Region: ATP-grasp_4; cl17255
479433009830	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
479433009831	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
479433009832	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
479433009833	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
479433009834	carboxyltransferase (CT) interaction site; other site
479433009835	biotinylation site [posttranslational modification]; other site
479433009836	allophanate hydrolase; Provisional; Region: PRK08186
479433009837	Amidase; Region: Amidase; cl11426
479433009838	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433009839	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433009840	Domain of unknown function (DUF4135); Region: DUF4135; pfam13575
479433009841	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
479433009842	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
479433009843	active site
479433009844	zinc binding site [ion binding]; other site
479433009845	AAA ATPase domain; Region: AAA_16; pfam13191
479433009846	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433009847	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433009848	DNA binding residues [nucleotide binding]
479433009849	dimerization interface [polypeptide binding]; other site
479433009850	TPR repeat; Region: TPR_11; pfam13414
479433009851	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433009852	binding surface
479433009853	TPR motif; other site
479433009854	TPR repeat; Region: TPR_11; pfam13414
479433009855	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433009856	binding surface
479433009857	TPR motif; other site
479433009858	TPR repeat; Region: TPR_11; pfam13414
479433009859	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433009860	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433009861	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
479433009862	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433009863	NAD(P) binding site [chemical binding]; other site
479433009864	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
479433009865	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
479433009866	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
479433009867	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
479433009868	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
479433009869	SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833
479433009870	active site
479433009871	catalytic triad [active]
479433009872	oxyanion hole [active]
479433009873	Ricin-type beta-trefoil; Region: RICIN; smart00458
479433009874	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433009875	putative sugar binding sites [chemical binding]; other site
479433009876	Q-X-W motif; other site
479433009877	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433009878	sequence-specific DNA binding site [nucleotide binding]; other site
479433009879	salt bridge; other site
479433009880	AAA domain; Region: AAA_22; pfam13401
479433009881	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433009882	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
479433009883	TPR motif; other site
479433009884	binding surface
479433009885	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433009886	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433009887	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433009888	binding surface
479433009889	TPR motif; other site
479433009890	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433009891	Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426
479433009892	polypeptide substrate binding site [polypeptide binding]; other site
479433009893	active site
479433009894	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433009895	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433009896	active site
479433009897	phosphorylation site [posttranslational modification]
479433009898	intermolecular recognition site; other site
479433009899	dimerization interface [polypeptide binding]; other site
479433009900	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433009901	dimerization interface [polypeptide binding]; other site
479433009902	DNA binding residues [nucleotide binding]
479433009903	Histidine kinase; Region: HisKA_3; pfam07730
479433009904	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433009905	ATP binding site [chemical binding]; other site
479433009906	Mg2+ binding site [ion binding]; other site
479433009907	G-X-G motif; other site
479433009908	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
479433009909	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433009910	S-adenosylmethionine binding site [chemical binding]; other site
479433009911	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
479433009912	DNA binding site [nucleotide binding]
479433009913	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433009914	AAA ATPase domain; Region: AAA_16; pfam13191
479433009915	NACHT domain; Region: NACHT; pfam05729
479433009916	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
479433009917	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433009918	Walker A/P-loop; other site
479433009919	ATP binding site [chemical binding]; other site
479433009920	Q-loop/lid; other site
479433009921	ABC transporter signature motif; other site
479433009922	Walker B; other site
479433009923	D-loop; other site
479433009924	H-loop/switch region; other site
479433009925	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
479433009926	Catalytic site [active]
479433009927	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
479433009928	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
479433009929	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
479433009930	ATP-grasp domain; Region: ATP-grasp_4; cl17255
479433009931	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
479433009932	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
479433009933	carboxyltransferase (CT) interaction site; other site
479433009934	biotinylation site [posttranslational modification]; other site
479433009935	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
479433009936	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
479433009937	trimer interface [polypeptide binding]; other site
479433009938	oxyanion hole (OAH) forming residues; other site
479433009939	hypothetical protein; Provisional; Region: PRK07505
479433009940	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
479433009941	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433009942	catalytic residue [active]
479433009943	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
479433009944	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
479433009945	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
479433009946	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
479433009947	active site
479433009948	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
479433009949	dimer interface [polypeptide binding]; other site
479433009950	non-prolyl cis peptide bond; other site
479433009951	insertion regions; other site
479433009952	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
479433009953	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
479433009954	substrate binding pocket [chemical binding]; other site
479433009955	membrane-bound complex binding site; other site
479433009956	hinge residues; other site
479433009957	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
479433009958	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
479433009959	Walker A/P-loop; other site
479433009960	ATP binding site [chemical binding]; other site
479433009961	Q-loop/lid; other site
479433009962	ABC transporter signature motif; other site
479433009963	Walker B; other site
479433009964	D-loop; other site
479433009965	H-loop/switch region; other site
479433009966	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
479433009967	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433009968	dimer interface [polypeptide binding]; other site
479433009969	conserved gate region; other site
479433009970	putative PBP binding loops; other site
479433009971	ABC-ATPase subunit interface; other site
479433009972	Predicted transcriptional regulator [Transcription]; Region: COG1959
479433009973	Transcriptional regulator; Region: Rrf2; pfam02082
479433009974	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
479433009975	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
479433009976	substrate binding pocket [chemical binding]; other site
479433009977	membrane-bound complex binding site; other site
479433009978	hinge residues; other site
479433009979	glycogen branching enzyme; Provisional; Region: PRK12313
479433009980	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
479433009981	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
479433009982	active site
479433009983	catalytic site [active]
479433009984	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
479433009985	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
479433009986	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
479433009987	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433009988	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
479433009989	nucleotide binding site [chemical binding]; other site
479433009990	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
479433009991	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
479433009992	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
479433009993	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
479433009994	substrate binding pocket [chemical binding]; other site
479433009995	active site
479433009996	iron coordination sites [ion binding]; other site
479433009997	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
479433009998	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
479433009999	active site
479433010000	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
479433010001	dimer interface [polypeptide binding]; other site
479433010002	non-prolyl cis peptide bond; other site
479433010003	insertion regions; other site
479433010004	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
479433010005	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
479433010006	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
479433010007	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
479433010008	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
479433010009	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
479433010010	Walker A/P-loop; other site
479433010011	ATP binding site [chemical binding]; other site
479433010012	Q-loop/lid; other site
479433010013	ABC transporter signature motif; other site
479433010014	Walker B; other site
479433010015	D-loop; other site
479433010016	H-loop/switch region; other site
479433010017	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
479433010018	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
479433010019	active site
479433010020	non-prolyl cis peptide bond; other site
479433010021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433010022	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
479433010023	Walker A/P-loop; other site
479433010024	ATP binding site [chemical binding]; other site
479433010025	Q-loop/lid; other site
479433010026	ABC transporter signature motif; other site
479433010027	Walker B; other site
479433010028	D-loop; other site
479433010029	H-loop/switch region; other site
479433010030	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
479433010031	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
479433010032	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433010033	Walker A/P-loop; other site
479433010034	ATP binding site [chemical binding]; other site
479433010035	Q-loop/lid; other site
479433010036	ABC transporter signature motif; other site
479433010037	Walker B; other site
479433010038	D-loop; other site
479433010039	H-loop/switch region; other site
479433010040	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433010041	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433010042	active site
479433010043	catalytic tetrad [active]
479433010044	putative oxidoreductase; Provisional; Region: PRK08275
479433010045	L-aspartate oxidase; Provisional; Region: PRK06175
479433010046	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
479433010047	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
479433010048	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
479433010049	Walker A/P-loop; other site
479433010050	ATP binding site [chemical binding]; other site
479433010051	Q-loop/lid; other site
479433010052	ABC transporter signature motif; other site
479433010053	Walker B; other site
479433010054	D-loop; other site
479433010055	H-loop/switch region; other site
479433010056	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
479433010057	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433010058	putative PBP binding loops; other site
479433010059	ABC-ATPase subunit interface; other site
479433010060	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
479433010061	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
479433010062	substrate binding pocket [chemical binding]; other site
479433010063	membrane-bound complex binding site; other site
479433010064	hinge residues; other site
479433010065	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
479433010066	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
479433010067	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433010068	DNA-binding site [nucleotide binding]; DNA binding site
479433010069	UTRA domain; Region: UTRA; pfam07702
479433010070	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
479433010071	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
479433010072	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
479433010073	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433010074	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433010075	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
479433010076	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
479433010077	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
479433010078	active site
479433010079	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
479433010080	non-prolyl cis peptide bond; other site
479433010081	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433010082	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
479433010083	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
479433010084	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433010085	dimer interface [polypeptide binding]; other site
479433010086	conserved gate region; other site
479433010087	putative PBP binding loops; other site
479433010088	ABC-ATPase subunit interface; other site
479433010089	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
479433010090	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
479433010091	Walker A/P-loop; other site
479433010092	ATP binding site [chemical binding]; other site
479433010093	Q-loop/lid; other site
479433010094	ABC transporter signature motif; other site
479433010095	Walker B; other site
479433010096	D-loop; other site
479433010097	H-loop/switch region; other site
479433010098	Erythromycin esterase; Region: Erythro_esteras; cl17110
479433010099	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433010100	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433010101	putative sugar binding sites [chemical binding]; other site
479433010102	Q-X-W motif; other site
479433010103	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
479433010104	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433010105	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433010106	putative sugar binding sites [chemical binding]; other site
479433010107	Q-X-W motif; other site
479433010108	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433010109	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433010110	dimer interface [polypeptide binding]; other site
479433010111	conserved gate region; other site
479433010112	putative PBP binding loops; other site
479433010113	ABC-ATPase subunit interface; other site
479433010114	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
479433010115	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433010116	putative PBP binding loops; other site
479433010117	ABC-ATPase subunit interface; other site
479433010118	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433010119	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433010120	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752
479433010121	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167
479433010122	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
479433010123	putative ligand binding site [chemical binding]; other site
479433010124	putative NAD binding site [chemical binding]; other site
479433010125	catalytic site [active]
479433010126	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
479433010127	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433010128	DNA-binding site [nucleotide binding]; DNA binding site
479433010129	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433010130	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
479433010131	ligand binding site [chemical binding]; other site
479433010132	dimerization interface [polypeptide binding]; other site
479433010133	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433010134	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433010135	Predicted transcriptional regulators [Transcription]; Region: COG1695
479433010136	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
479433010137	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
479433010138	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
479433010139	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
479433010140	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
479433010141	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
479433010142	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433010143	dimer interface [polypeptide binding]; other site
479433010144	conserved gate region; other site
479433010145	putative PBP binding loops; other site
479433010146	ABC-ATPase subunit interface; other site
479433010147	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433010148	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
479433010149	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
479433010150	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433010151	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
479433010152	Glycosyl hydrolase family 67 middle domain; Region: Glyco_hydro_67M; pfam07488
479433010153	Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477
479433010154	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433010155	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
479433010156	putative NAD(P) binding site [chemical binding]; other site
479433010157	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
479433010158	MOSC domain; Region: MOSC; pfam03473
479433010159	3-alpha domain; Region: 3-alpha; pfam03475
479433010160	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
479433010161	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
479433010162	FAD binding pocket [chemical binding]; other site
479433010163	FAD binding motif [chemical binding]; other site
479433010164	phosphate binding motif [ion binding]; other site
479433010165	beta-alpha-beta structure motif; other site
479433010166	NAD binding pocket [chemical binding]; other site
479433010167	Heme binding  pocket [chemical binding]; other site
479433010168	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
479433010169	catalytic loop [active]
479433010170	iron binding site [ion binding]; other site
479433010171	FOG: WD40 repeat [General function prediction only]; Region: COG2319
479433010172	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
479433010173	structural tetrad; other site
479433010174	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
479433010175	FOG: WD40 repeat [General function prediction only]; Region: COG2319
479433010176	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
479433010177	structural tetrad; other site
479433010178	Right handed beta helix region; Region: Beta_helix; pfam13229
479433010179	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
479433010180	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
479433010181	CARDB; Region: CARDB; pfam07705
479433010182	Protein of unknown function DUF58; Region: DUF58; pfam01882
479433010183	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433010184	MoxR-like ATPases [General function prediction only]; Region: COG0714
479433010185	Walker A motif; other site
479433010186	ATP binding site [chemical binding]; other site
479433010187	Walker B motif; other site
479433010188	arginine finger; other site
479433010189	Uncharacterized conserved protein [Function unknown]; Region: COG5361
479433010190	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
479433010191	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
479433010192	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
479433010193	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
479433010194	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
479433010195	Sulfate transporter family; Region: Sulfate_transp; pfam00916
479433010196	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
479433010197	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
479433010198	NHL repeat; Region: NHL; pfam01436
479433010199	Phosphoesterase family; Region: Phosphoesterase; pfam04185
479433010200	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433010201	sugar binding site [chemical binding]; other site
479433010202	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433010203	sugar binding site [chemical binding]; other site
479433010204	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
479433010205	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
479433010206	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
479433010207	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
479433010208	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433010209	MarR family; Region: MarR_2; pfam12802
479433010210	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
479433010211	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433010212	NAD(P) binding site [chemical binding]; other site
479433010213	active site
479433010214	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
479433010215	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
479433010216	apolar tunnel; other site
479433010217	heme binding site [chemical binding]; other site
479433010218	dimerization interface [polypeptide binding]; other site
479433010219	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
479433010220	dimerization interface [polypeptide binding]; other site
479433010221	active site
479433010222	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722
479433010223	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
479433010224	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
479433010225	Recombinase; Region: Recombinase; pfam07508
479433010226	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
479433010227	CHAT domain; Region: CHAT; cl17868
479433010228	NACHT domain; Region: NACHT; pfam05729
479433010229	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
479433010230	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433010231	Walker A motif; other site
479433010232	ATP binding site [chemical binding]; other site
479433010233	Walker B motif; other site
479433010234	arginine finger; other site
479433010235	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
479433010236	Integrase core domain; Region: rve; pfam00665
479433010237	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
479433010238	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
479433010239	CHAT domain; Region: CHAT; cl17868
479433010240	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
479433010241	Walker A motif; other site
479433010242	ATP binding site [chemical binding]; other site
479433010243	Walker B motif; other site
479433010244	DDE superfamily endonuclease; Region: DDE_3; pfam13358
479433010245	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
479433010246	Helix-turn-helix domain; Region: HTH_28; pfam13518
479433010247	Winged helix-turn helix; Region: HTH_33; pfam13592
479433010248	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
479433010249	catalytic residues [active]
479433010250	catalytic nucleophile [active]
479433010251	Recombinase; Region: Recombinase; pfam07508
479433010252	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
479433010253	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
479433010254	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
479433010255	ABC-2 type transporter; Region: ABC2_membrane; cl17235
479433010256	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
479433010257	FAD binding domain; Region: FAD_binding_3; pfam01494
479433010258	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
479433010259	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
479433010260	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433010261	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433010262	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433010263	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433010264	putative substrate translocation pore; other site
479433010265	Iron permease FTR1 family; Region: FTR1; cl00475
479433010266	inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378
479433010267	Imelysin; Region: Peptidase_M75; pfam09375
479433010268	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
479433010269	Peptidases of the G1 family and homologs that might lack peptidase activity; Region: Peptidase_G1_like; cl03371
479433010270	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755
479433010271	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
479433010272	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
479433010273	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
479433010274	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756
479433010275	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608
479433010276	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731
479433010277	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
479433010278	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
479433010279	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729
479433010280	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
479433010281	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
479433010282	Walker A/P-loop; other site
479433010283	ATP binding site [chemical binding]; other site
479433010284	Q-loop/lid; other site
479433010285	ABC transporter signature motif; other site
479433010286	Walker B; other site
479433010287	D-loop; other site
479433010288	H-loop/switch region; other site
479433010289	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
479433010290	putative hydrophobic ligand binding site [chemical binding]; other site
479433010291	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
479433010292	Amidohydrolase; Region: Amidohydro_2; pfam04909
479433010293	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
479433010294	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
479433010295	PYR/PP interface [polypeptide binding]; other site
479433010296	dimer interface [polypeptide binding]; other site
479433010297	TPP binding site [chemical binding]; other site
479433010298	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
479433010299	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
479433010300	TPP-binding site [chemical binding]; other site
479433010301	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
479433010302	NMT1/THI5 like; Region: NMT1; pfam09084
479433010303	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
479433010304	Amidohydrolase; Region: Amidohydro_2; pfam04909
479433010305	active site
479433010306	Transcriptional regulators [Transcription]; Region: GntR; COG1802
479433010307	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433010308	DNA-binding site [nucleotide binding]; DNA binding site
479433010309	FCD domain; Region: FCD; pfam07729
479433010310	NMT1/THI5 like; Region: NMT1; pfam09084
479433010311	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
479433010312	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
479433010313	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
479433010314	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
479433010315	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
479433010316	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
479433010317	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433010318	non-specific DNA binding site [nucleotide binding]; other site
479433010319	salt bridge; other site
479433010320	sequence-specific DNA binding site [nucleotide binding]; other site
479433010321	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
479433010322	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
479433010323	putative NAD(P) binding site [chemical binding]; other site
479433010324	active site
479433010325	FxLD family lantipeptide; Region: LD_lanti_pre; TIGR04363
479433010326	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
479433010327	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
479433010328	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
479433010329	active site
479433010330	zinc binding site [ion binding]; other site
479433010331	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
479433010332	methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364
479433010333	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433010334	S-adenosylmethionine binding site [chemical binding]; other site
479433010335	Domain of unknown function (DUF397); Region: DUF397; pfam04149
479433010336	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
479433010337	AAA domain; Region: AAA_22; pfam13401
479433010338	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433010339	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433010340	TPR motif; other site
479433010341	binding surface
479433010342	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433010343	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433010344	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
479433010345	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433010346	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433010347	DNA binding residues [nucleotide binding]
479433010348	dimerization interface [polypeptide binding]; other site
479433010349	AAA domain; Region: AAA_18; pfam13238
479433010350	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
479433010351	active site
479433010352	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
479433010353	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
479433010354	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433010355	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433010356	Walker A/P-loop; other site
479433010357	ATP binding site [chemical binding]; other site
479433010358	Q-loop/lid; other site
479433010359	ABC transporter signature motif; other site
479433010360	Walker B; other site
479433010361	D-loop; other site
479433010362	H-loop/switch region; other site
479433010363	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433010364	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433010365	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
479433010366	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
479433010367	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
479433010368	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433010369	salt bridge; other site
479433010370	non-specific DNA binding site [nucleotide binding]; other site
479433010371	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433010372	sequence-specific DNA binding site [nucleotide binding]; other site
479433010373	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
479433010374	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
479433010375	metal binding site [ion binding]; metal-binding site
479433010376	active site
479433010377	I-site; other site
479433010378	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
479433010379	Winged helix-turn helix; Region: HTH_29; pfam13551
479433010380	Homeodomain-like domain; Region: HTH_23; pfam13384
479433010381	Homeodomain-like domain; Region: HTH_32; pfam13565
479433010382	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
479433010383	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
479433010384	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
479433010385	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
479433010386	Protein of unknown function DUF262; Region: DUF262; pfam03235
479433010387	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
479433010388	PLD-like domain; Region: PLDc_2; pfam13091
479433010389	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
479433010390	putative active site [active]
479433010391	putative active site [active]
479433010392	catalytic site [active]
479433010393	catalytic site [active]
479433010394	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
479433010395	putative Mg++ binding site [ion binding]; other site
479433010396	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
479433010397	ATP-binding site [chemical binding]; other site
479433010398	CopC domain; Region: CopC; pfam04234
479433010399	Copper resistance protein D; Region: CopD; cl00563
479433010400	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
479433010401	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
479433010402	Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829
479433010403	active site
479433010404	putative catalytic site [active]
479433010405	Putative zinc-finger; Region: zf-HC2; pfam13490
479433010406	Anti-sigma-K factor rskA; Region: RskA; pfam10099
479433010407	RNA polymerase sigma factor; Provisional; Region: PRK12537
479433010408	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433010409	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433010410	DNA binding residues [nucleotide binding]
479433010411	Ferritin-like domain; Region: Ferritin_2; pfam13668
479433010412	Ferritin-like domain; Region: Ferritin_2; pfam13668
479433010413	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
479433010414	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
479433010415	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433010416	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433010417	DNA binding residues [nucleotide binding]
479433010418	Domain of unknown function (DUF4331); Region: DUF4331; pfam14224
479433010419	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
479433010420	TPR motif; other site
479433010421	binding surface
479433010422	High-affinity nickel-transport protein; Region: NicO; cl00964
479433010423	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
479433010424	anti sigma factor interaction site; other site
479433010425	regulatory phosphorylation site [posttranslational modification]; other site
479433010426	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
479433010427	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433010428	S-adenosylmethionine binding site [chemical binding]; other site
479433010429	PRC-barrel domain; Region: PRC; pfam05239
479433010430	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
479433010431	anti sigma factor interaction site; other site
479433010432	regulatory phosphorylation site [posttranslational modification]; other site
479433010433	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433010434	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433010435	NMT1/THI5 like; Region: NMT1; pfam09084
479433010436	NAD synthase; Region: NAD_synthase; pfam02540
479433010437	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
479433010438	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
479433010439	putative active site [active]
479433010440	putative NTP binding site [chemical binding]; other site
479433010441	putative nucleic acid binding site [nucleotide binding]; other site
479433010442	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
479433010443	transposase; Provisional; Region: PRK06526
479433010444	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433010445	Walker A motif; other site
479433010446	ATP binding site [chemical binding]; other site
479433010447	Walker B motif; other site
479433010448	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
479433010449	active site
479433010450	ATP binding site [chemical binding]; other site
479433010451	Uncharacterized conserved protein [Function unknown]; Region: COG4278
479433010452	CAAX protease self-immunity; Region: Abi; pfam02517
479433010453	Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719
479433010454	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
479433010455	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433010456	NAD(P) binding site [chemical binding]; other site
479433010457	active site
479433010458	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433010459	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433010460	non-specific DNA binding site [nucleotide binding]; other site
479433010461	salt bridge; other site
479433010462	sequence-specific DNA binding site [nucleotide binding]; other site
479433010463	PknH-like extracellular domain; Region: PknH_C; pfam14032
479433010464	Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630
479433010465	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
479433010466	ATP binding site [chemical binding]; other site
479433010467	Walker A motif; other site
479433010468	hexamer interface [polypeptide binding]; other site
479433010469	Walker B motif; other site
479433010470	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
479433010471	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
479433010472	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
479433010473	MarR family; Region: MarR_2; pfam12802
479433010474	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
479433010475	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
479433010476	active site
479433010477	DEAD-like helicases superfamily; Region: DEXDc; smart00487
479433010478	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
479433010479	putative peptide-modifying radical SAM enzyme, AF0577 family; Region: rSAM_AF0577; TIGR04084
479433010480	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
479433010481	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
479433010482	Domain of unknown function (DUF317); Region: SPDY; pfam03771
479433010483	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
479433010484	MoxR-like ATPases [General function prediction only]; Region: COG0714
479433010485	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433010486	Walker A motif; other site
479433010487	ATP binding site [chemical binding]; other site
479433010488	Walker B motif; other site
479433010489	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
479433010490	N-acetyl-D-glucosamine binding site [chemical binding]; other site
479433010491	catalytic residue [active]
479433010492	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
479433010493	NlpC/P60 family; Region: NLPC_P60; pfam00877
479433010494	Replication-relaxation; Region: Replic_Relax; pfam13814
479433010495	AAA-like domain; Region: AAA_10; pfam12846
479433010496	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
479433010497	Walker A motif; other site
479433010498	ATP binding site [chemical binding]; other site
479433010499	Walker B motif; other site
479433010500	AAA-like domain; Region: AAA_10; pfam12846
479433010501	Domain of unknown function DUF87; Region: DUF87; pfam01935
479433010502	PrgI family protein; Region: PrgI; pfam12666
479433010503	DNA methylase; Region: N6_N4_Mtase; pfam01555
479433010504	Methyltransferase domain; Region: Methyltransf_26; pfam13659
479433010505	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
479433010506	Ligand Binding Site [chemical binding]; other site
479433010507	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
479433010508	catalytic nucleophile [active]
479433010509	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
479433010510	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
479433010511	catalytic residues [active]
479433010512	catalytic nucleophile [active]
479433010513	Recombinase; Region: Recombinase; pfam07508
479433010514	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
479433010515	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
479433010516	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
479433010517	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
479433010518	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433010519	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433010520	ATP binding site [chemical binding]; other site
479433010521	Mg2+ binding site [ion binding]; other site
479433010522	G-X-G motif; other site
479433010523	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
479433010524	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
479433010525	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
479433010526	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
479433010527	Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200
479433010528	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433010529	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433010530	putative sugar binding sites [chemical binding]; other site
479433010531	Q-X-W motif; other site
479433010532	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433010533	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433010534	putative sugar binding sites [chemical binding]; other site
479433010535	Q-X-W motif; other site
479433010536	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433010537	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433010538	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
479433010539	putative dimerization interface [polypeptide binding]; other site
479433010540	EamA-like transporter family; Region: EamA; pfam00892
479433010541	EamA-like transporter family; Region: EamA; pfam00892
479433010542	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433010543	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
479433010544	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433010545	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433010546	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433010547	DNA binding residues [nucleotide binding]
479433010548	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
479433010549	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
479433010550	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
479433010551	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
479433010552	active site
479433010553	substrate binding site [chemical binding]; other site
479433010554	FMN binding site [chemical binding]; other site
479433010555	putative catalytic residues [active]
479433010556	Cytochrome P450; Region: p450; cl12078
479433010557	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433010558	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
479433010559	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
479433010560	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433010561	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433010562	active site
479433010563	phosphorylation site [posttranslational modification]
479433010564	intermolecular recognition site; other site
479433010565	dimerization interface [polypeptide binding]; other site
479433010566	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433010567	DNA binding site [nucleotide binding]
479433010568	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433010569	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433010570	dimer interface [polypeptide binding]; other site
479433010571	phosphorylation site [posttranslational modification]
479433010572	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433010573	ATP binding site [chemical binding]; other site
479433010574	Mg2+ binding site [ion binding]; other site
479433010575	G-X-G motif; other site
479433010576	Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182
479433010577	active site
479433010578	catalytic residues [active]
479433010579	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433010580	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433010581	putative sugar binding sites [chemical binding]; other site
479433010582	Q-X-W motif; other site
479433010583	Putative Ig domain; Region: He_PIG; pfam05345
479433010584	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433010585	sugar binding site [chemical binding]; other site
479433010586	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433010587	sugar binding site [chemical binding]; other site
479433010588	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
479433010589	MarR family; Region: MarR; pfam01047
479433010590	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433010591	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
479433010592	anti sigma factor interaction site; other site
479433010593	regulatory phosphorylation site [posttranslational modification]; other site
479433010594	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
479433010595	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433010596	dimerization interface [polypeptide binding]; other site
479433010597	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433010598	dimerization interface [polypeptide binding]; other site
479433010599	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433010600	dimerization interface [polypeptide binding]; other site
479433010601	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
479433010602	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433010603	dimerization interface [polypeptide binding]; other site
479433010604	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433010605	dimerization interface [polypeptide binding]; other site
479433010606	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433010607	dimerization interface [polypeptide binding]; other site
479433010608	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433010609	dimerization interface [polypeptide binding]; other site
479433010610	GAF domain; Region: GAF_2; pfam13185
479433010611	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
479433010612	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433010613	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
479433010614	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433010615	ATP binding site [chemical binding]; other site
479433010616	Mg2+ binding site [ion binding]; other site
479433010617	G-X-G motif; other site
479433010618	Response regulator receiver domain; Region: Response_reg; pfam00072
479433010619	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433010620	active site
479433010621	phosphorylation site [posttranslational modification]
479433010622	intermolecular recognition site; other site
479433010623	dimerization interface [polypeptide binding]; other site
479433010624	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
479433010625	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
479433010626	Putative catalytic domain, repeat 1, of Yersinia pestis murine toxin-like proteins; Region: PLDc_Ymt_1; cd09150
479433010627	putative active site [active]
479433010628	catalytic site [active]
479433010629	Putative catalytic domain, repeat 2, of Yersinia pestis murine toxin-like proteins; Region: PLDc_Ymt_2; cd09151
479433010630	PLD-like domain; Region: PLDc_2; pfam13091
479433010631	putative active site [active]
479433010632	catalytic site [active]
479433010633	Jacalin-like lectin domain; Region: Jacalin_like; cd09302
479433010634	putative sugar binding site [chemical binding]; other site
479433010635	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433010636	putative transporter; Provisional; Region: PRK10504
479433010637	putative substrate translocation pore; other site
479433010638	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
479433010639	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433010640	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433010641	putative substrate translocation pore; other site
479433010642	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433010643	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
479433010644	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433010645	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433010646	sequence-specific DNA binding site [nucleotide binding]; other site
479433010647	salt bridge; other site
479433010648	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
479433010649	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
479433010650	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433010651	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433010652	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
479433010653	SnoaL-like domain; Region: SnoaL_2; pfam12680
479433010654	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
479433010655	PQQ-like domain; Region: PQQ_2; pfam13360
479433010656	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
479433010657	Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576
479433010658	putative ligand binding site [chemical binding]; other site
479433010659	putative catalytic site [active]
479433010660	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
479433010661	Bulb-type mannose-specific lectin; Region: B_lectin; smart00108
479433010662	dimerization interface [polypeptide binding]; other site
479433010663	mannose binding site [chemical binding]; other site
479433010664	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433010665	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433010666	putative substrate translocation pore; other site
479433010667	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433010668	MarR family; Region: MarR_2; pfam12802
479433010669	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
479433010670	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433010671	active site
479433010672	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
479433010673	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
479433010674	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
479433010675	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
479433010676	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
479433010677	conserved cys residue [active]
479433010678	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433010679	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433010680	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433010681	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433010682	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433010683	DNA binding residues [nucleotide binding]
479433010684	YceG-like family; Region: YceG; pfam02618
479433010685	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
479433010686	dimerization interface [polypeptide binding]; other site
479433010687	Penicillinase repressor; Region: Pencillinase_R; pfam03965
479433010688	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
479433010689	catalytic residues [active]
479433010690	catalytic nucleophile [active]
479433010691	Recombinase; Region: Recombinase; pfam07508
479433010692	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
479433010693	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
479433010694	active site
479433010695	catalytic triad [active]
479433010696	calcium binding site [ion binding]; other site
479433010697	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
479433010698	CsbD-like; Region: CsbD; cl17424
479433010699	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433010700	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
479433010701	NAD(P) binding site [chemical binding]; other site
479433010702	active site
479433010703	Helix-turn-helix domain; Region: HTH_18; pfam12833
479433010704	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
479433010705	putative acyl-acceptor binding pocket; other site
479433010706	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
479433010707	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
479433010708	active site
479433010709	nucleophile elbow; other site
479433010710	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433010711	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433010712	putative substrate translocation pore; other site
479433010713	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
479433010714	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
479433010715	putative molybdopterin cofactor binding site [chemical binding]; other site
479433010716	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
479433010717	putative molybdopterin cofactor binding site; other site
479433010718	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
479433010719	Cellulose binding domain; Region: CBM_2; pfam00553
479433010720	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
479433010721	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
479433010722	Walker A/P-loop; other site
479433010723	ATP binding site [chemical binding]; other site
479433010724	Q-loop/lid; other site
479433010725	ABC transporter signature motif; other site
479433010726	Walker B; other site
479433010727	D-loop; other site
479433010728	H-loop/switch region; other site
479433010729	Predicted transcriptional regulators [Transcription]; Region: COG1695
479433010730	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
479433010731	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
479433010732	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
479433010733	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
479433010734	metal binding site [ion binding]; metal-binding site
479433010735	active site
479433010736	I-site; other site
479433010737	PAS domain; Region: PAS_9; pfam13426
479433010738	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
479433010739	putative active site [active]
479433010740	heme pocket [chemical binding]; other site
479433010741	PAS fold; Region: PAS_4; pfam08448
479433010742	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
479433010743	putative active site [active]
479433010744	heme pocket [chemical binding]; other site
479433010745	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
479433010746	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433010747	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433010748	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
479433010749	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
479433010750	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
479433010751	NAD binding site [chemical binding]; other site
479433010752	catalytic Zn binding site [ion binding]; other site
479433010753	substrate binding site [chemical binding]; other site
479433010754	structural Zn binding site [ion binding]; other site
479433010755	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
479433010756	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
479433010757	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
479433010758	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
479433010759	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
479433010760	FtsX-like permease family; Region: FtsX; pfam02687
479433010761	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
479433010762	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
479433010763	Walker A/P-loop; other site
479433010764	ATP binding site [chemical binding]; other site
479433010765	Q-loop/lid; other site
479433010766	ABC transporter signature motif; other site
479433010767	Walker B; other site
479433010768	D-loop; other site
479433010769	H-loop/switch region; other site
479433010770	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
479433010771	aconitate hydratase; Validated; Region: PRK07229
479433010772	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
479433010773	substrate binding site [chemical binding]; other site
479433010774	ligand binding site [chemical binding]; other site
479433010775	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
479433010776	substrate binding site [chemical binding]; other site
479433010777	amino acid transporter; Region: 2A0306; TIGR00909
479433010778	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
479433010779	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433010780	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433010781	ATP binding site [chemical binding]; other site
479433010782	Mg2+ binding site [ion binding]; other site
479433010783	G-X-G motif; other site
479433010784	Roadblock/LC7 domain; Region: Robl_LC7; pfam03259
479433010785	Protein of unknown function (DUF742); Region: DUF742; pfam05331
479433010786	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
479433010787	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
479433010788	G1 box; other site
479433010789	GTP/Mg2+ binding site [chemical binding]; other site
479433010790	G2 box; other site
479433010791	Switch I region; other site
479433010792	G3 box; other site
479433010793	Switch II region; other site
479433010794	G4 box; other site
479433010795	G5 box; other site
479433010796	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433010797	Cytochrome P450; Region: p450; cl12078
479433010798	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433010799	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433010800	dimerization interface [polypeptide binding]; other site
479433010801	putative DNA binding site [nucleotide binding]; other site
479433010802	putative Zn2+ binding site [ion binding]; other site
479433010803	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
479433010804	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433010805	Coenzyme A binding pocket [chemical binding]; other site
479433010806	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
479433010807	MarR family; Region: MarR_2; cl17246
479433010808	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
479433010809	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433010810	Coenzyme A binding pocket [chemical binding]; other site
479433010811	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433010812	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433010813	active site
479433010814	catalytic tetrad [active]
479433010815	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433010816	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433010817	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433010818	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433010819	active site
479433010820	phosphorylation site [posttranslational modification]
479433010821	intermolecular recognition site; other site
479433010822	dimerization interface [polypeptide binding]; other site
479433010823	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433010824	DNA binding site [nucleotide binding]
479433010825	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433010826	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433010827	dimer interface [polypeptide binding]; other site
479433010828	phosphorylation site [posttranslational modification]
479433010829	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433010830	ATP binding site [chemical binding]; other site
479433010831	Mg2+ binding site [ion binding]; other site
479433010832	G-X-G motif; other site
479433010833	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
479433010834	Predicted ATPase [General function prediction only]; Region: COG3899
479433010835	AAA ATPase domain; Region: AAA_16; pfam13191
479433010836	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433010837	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433010838	DNA binding residues [nucleotide binding]
479433010839	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
479433010840	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
479433010841	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
479433010842	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
479433010843	metal binding site [ion binding]; metal-binding site
479433010844	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
479433010845	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
479433010846	YcaO-like family; Region: YcaO; pfam02624
479433010847	ABC-2 type transporter; Region: ABC2_membrane; cl17235
479433010848	Peptidase family M50; Region: Peptidase_M50; pfam02163
479433010849	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709
479433010850	active site
479433010851	putative substrate binding region [chemical binding]; other site
479433010852	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433010853	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
479433010854	Walker A/P-loop; other site
479433010855	ATP binding site [chemical binding]; other site
479433010856	Q-loop/lid; other site
479433010857	ABC transporter signature motif; other site
479433010858	Walker B; other site
479433010859	D-loop; other site
479433010860	H-loop/switch region; other site
479433010861	SpaB C-terminal domain; Region: SpaB_C; pfam14028
479433010862	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
479433010863	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
479433010864	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
479433010865	NADPH bind site [chemical binding]; other site
479433010866	putative FMN binding site [chemical binding]; other site
479433010867	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
479433010868	dimer interface [polypeptide binding]; other site
479433010869	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
479433010870	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
479433010871	YcaO-like family; Region: YcaO; pfam02624
479433010872	putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693
479433010873	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
479433010874	YcaO-like family; Region: YcaO; pfam02624
479433010875	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433010876	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
479433010877	DNA binding site [nucleotide binding]
479433010878	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433010879	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
479433010880	dimerization interface [polypeptide binding]; other site
479433010881	DNA binding residues [nucleotide binding]
479433010882	Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155
479433010883	Phosphotransferase enzyme family; Region: APH; pfam01636
479433010884	putative active site [active]
479433010885	putative substrate binding site [chemical binding]; other site
479433010886	ATP binding site [chemical binding]; other site
479433010887	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
479433010888	Beta-lactamase; Region: Beta-lactamase; pfam00144
479433010889	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
479433010890	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
479433010891	Cellulose binding domain; Region: CBM_2; pfam00553
479433010892	Transcriptional regulators [Transcription]; Region: GntR; COG1802
479433010893	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433010894	DNA-binding site [nucleotide binding]; DNA binding site
479433010895	FCD domain; Region: FCD; pfam07729
479433010896	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
479433010897	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
479433010898	inhibitor site; inhibition site
479433010899	active site
479433010900	dimer interface [polypeptide binding]; other site
479433010901	catalytic residue [active]
479433010902	dihydroxy-acid dehydratase; Validated; Region: PRK06131
479433010903	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
479433010904	hypothetical protein; Provisional; Region: PRK11622
479433010905	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
479433010906	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433010907	Walker A/P-loop; other site
479433010908	ATP binding site [chemical binding]; other site
479433010909	Q-loop/lid; other site
479433010910	ABC transporter signature motif; other site
479433010911	Walker B; other site
479433010912	D-loop; other site
479433010913	H-loop/switch region; other site
479433010914	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433010915	dimer interface [polypeptide binding]; other site
479433010916	conserved gate region; other site
479433010917	putative PBP binding loops; other site
479433010918	ABC-ATPase subunit interface; other site
479433010919	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
479433010920	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433010921	dimer interface [polypeptide binding]; other site
479433010922	conserved gate region; other site
479433010923	putative PBP binding loops; other site
479433010924	ABC-ATPase subunit interface; other site
479433010925	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
479433010926	extended (e) SDRs; Region: SDR_e; cd08946
479433010927	NAD(P) binding site [chemical binding]; other site
479433010928	active site
479433010929	substrate binding site [chemical binding]; other site
479433010930	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
479433010931	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
479433010932	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
479433010933	active site
479433010934	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
479433010935	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433010936	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
479433010937	YCII-related domain; Region: YCII; cl00999
479433010938	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
479433010939	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433010940	AAA ATPase domain; Region: AAA_16; pfam13191
479433010941	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433010942	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433010943	DNA binding residues [nucleotide binding]
479433010944	dimerization interface [polypeptide binding]; other site
479433010945	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
479433010946	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433010947	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433010948	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433010949	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433010950	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433010951	AAA ATPase domain; Region: AAA_16; pfam13191
479433010952	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433010953	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433010954	DNA binding residues [nucleotide binding]
479433010955	dimerization interface [polypeptide binding]; other site
479433010956	AAA ATPase domain; Region: AAA_16; pfam13191
479433010957	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433010958	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433010959	DNA binding residues [nucleotide binding]
479433010960	dimerization interface [polypeptide binding]; other site
479433010961	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
479433010962	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433010963	active site
479433010964	ATP binding site [chemical binding]; other site
479433010965	substrate binding site [chemical binding]; other site
479433010966	activation loop (A-loop); other site
479433010967	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
479433010968	active site
479433010969	zinc binding site [ion binding]; other site
479433010970	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
479433010971	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433010972	Q-loop/lid; other site
479433010973	ABC transporter signature motif; other site
479433010974	Walker B; other site
479433010975	D-loop; other site
479433010976	H-loop/switch region; other site
479433010977	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
479433010978	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
479433010979	Walker A/P-loop; other site
479433010980	ATP binding site [chemical binding]; other site
479433010981	Q-loop/lid; other site
479433010982	ABC transporter signature motif; other site
479433010983	Walker B; other site
479433010984	D-loop; other site
479433010985	H-loop/switch region; other site
479433010986	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433010987	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
479433010988	phosphorylation site [posttranslational modification]
479433010989	intermolecular recognition site; other site
479433010990	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433010991	DNA binding residues [nucleotide binding]
479433010992	dimerization interface [polypeptide binding]; other site
479433010993	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
479433010994	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
479433010995	Transthyretin_like.  This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase).  TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222
479433010996	active site
479433010997	homotetramer interface [polypeptide binding]; other site
479433010998	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
479433010999	DNA binding site [nucleotide binding]
479433011000	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433011001	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
479433011002	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433011003	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433011004	binding surface
479433011005	TPR motif; other site
479433011006	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433011007	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
479433011008	active site
479433011009	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
479433011010	dimer interface [polypeptide binding]; other site
479433011011	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
479433011012	Ligand Binding Site [chemical binding]; other site
479433011013	Molecular Tunnel; other site
479433011014	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
479433011015	A subgroup of  the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568
479433011016	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
479433011017	active site
479433011018	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
479433011019	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
479433011020	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
479433011021	active site
479433011022	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
479433011023	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
479433011024	metal binding site [ion binding]; metal-binding site
479433011025	dimer interface [polypeptide binding]; other site
479433011026	Uncharacterized conserved protein [Function unknown]; Region: COG3375
479433011027	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
479433011028	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
479433011029	active site
479433011030	octamer interface [polypeptide binding]; other site
479433011031	Beta-lactamase; Region: Beta-lactamase; pfam00144
479433011032	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
479433011033	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
479433011034	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
479433011035	putative active site [active]
479433011036	putative catalytic site [active]
479433011037	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433011038	NADH(P)-binding; Region: NAD_binding_10; pfam13460
479433011039	NAD(P) binding site [chemical binding]; other site
479433011040	active site
479433011041	Predicted transcriptional regulators [Transcription]; Region: COG1733
479433011042	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433011043	dimerization interface [polypeptide binding]; other site
479433011044	putative DNA binding site [nucleotide binding]; other site
479433011045	putative Zn2+ binding site [ion binding]; other site
479433011046	Putative zinc-finger; Region: zf-HC2; pfam13490
479433011047	Anti-sigma-K factor rskA; Region: RskA; pfam10099
479433011048	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
479433011049	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433011050	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433011051	DNA binding residues [nucleotide binding]
479433011052	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
479433011053	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
479433011054	Moco binding site; other site
479433011055	metal coordination site [ion binding]; other site
479433011056	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
479433011057	Fasciclin domain; Region: Fasciclin; pfam02469
479433011058	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
479433011059	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
479433011060	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
479433011061	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
479433011062	DNA photolyase; Region: DNA_photolyase; pfam00875
479433011063	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
479433011064	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433011065	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
479433011066	Protein of unknown function (DUF2000); Region: DUF2000; cl02074
479433011067	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
479433011068	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
479433011069	putative DNA binding site [nucleotide binding]; other site
479433011070	putative Zn2+ binding site [ion binding]; other site
479433011071	AsnC family; Region: AsnC_trans_reg; pfam01037
479433011072	EthD domain; Region: EthD; cl17553
479433011073	Cupin; Region: Cupin_6; pfam12852
479433011074	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
479433011075	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433011076	MarR family; Region: MarR; pfam01047
479433011077	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433011078	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
479433011079	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
479433011080	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433011081	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433011082	putative sugar binding sites [chemical binding]; other site
479433011083	Q-X-W motif; other site
479433011084	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433011085	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
479433011086	ATP binding site [chemical binding]; other site
479433011087	Mg2+ binding site [ion binding]; other site
479433011088	G-X-G motif; other site
479433011089	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433011090	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
479433011091	active site
479433011092	dimerization interface [polypeptide binding]; other site
479433011093	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433011094	DNA binding residues [nucleotide binding]
479433011095	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
479433011096	dimer interface [polypeptide binding]; other site
479433011097	substrate binding site [chemical binding]; other site
479433011098	metal binding sites [ion binding]; metal-binding site
479433011099	CBD_II domain; Region: CBD_II; smart00637
479433011100	Chitin binding domain; Region: Chitin_bind_3; pfam03067
479433011101	Cellulose binding domain; Region: CBM_2; pfam00553
479433011102	Cellulose binding domain; Region: CBM_2; pfam00553
479433011103	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
479433011104	Interdomain contacts; other site
479433011105	Cytokine receptor motif; other site
479433011106	Cellulose binding domain; Region: CBM_2; pfam00553
479433011107	Condensation domain; Region: Condensation; pfam00668
479433011108	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
479433011109	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
479433011110	IucA / IucC family; Region: IucA_IucC; pfam04183
479433011111	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
479433011112	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
479433011113	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
479433011114	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
479433011115	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
479433011116	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
479433011117	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433011118	catalytic residue [active]
479433011119	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
479433011120	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
479433011121	FAD binding pocket [chemical binding]; other site
479433011122	FAD binding motif [chemical binding]; other site
479433011123	phosphate binding motif [ion binding]; other site
479433011124	NAD binding pocket [chemical binding]; other site
479433011125	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
479433011126	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
479433011127	intersubunit interface [polypeptide binding]; other site
479433011128	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
479433011129	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
479433011130	ABC-ATPase subunit  interface; other site
479433011131	dimer interface [polypeptide binding]; other site
479433011132	putative PBP binding regions; other site
479433011133	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
479433011134	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
479433011135	ABC-ATPase subunit  interface; other site
479433011136	dimer interface [polypeptide binding]; other site
479433011137	putative PBP binding regions; other site
479433011138	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
479433011139	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
479433011140	Walker A/P-loop; other site
479433011141	ATP binding site [chemical binding]; other site
479433011142	Q-loop/lid; other site
479433011143	ABC transporter signature motif; other site
479433011144	Walker B; other site
479433011145	D-loop; other site
479433011146	H-loop/switch region; other site
479433011147	NMT1-like family; Region: NMT1_2; pfam13379
479433011148	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
479433011149	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
479433011150	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433011151	dimer interface [polypeptide binding]; other site
479433011152	conserved gate region; other site
479433011153	putative PBP binding loops; other site
479433011154	ABC-ATPase subunit interface; other site
479433011155	FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567
479433011156	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
479433011157	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
479433011158	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
479433011159	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
479433011160	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
479433011161	Walker A/P-loop; other site
479433011162	ATP binding site [chemical binding]; other site
479433011163	Q-loop/lid; other site
479433011164	ABC transporter signature motif; other site
479433011165	Walker B; other site
479433011166	D-loop; other site
479433011167	H-loop/switch region; other site
479433011168	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
479433011169	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433011170	putative PBP binding loops; other site
479433011171	dimer interface [polypeptide binding]; other site
479433011172	ABC-ATPase subunit interface; other site
479433011173	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
479433011174	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
479433011175	active site
479433011176	non-prolyl cis peptide bond; other site
479433011177	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
479433011178	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
479433011179	active site
479433011180	iron coordination sites [ion binding]; other site
479433011181	substrate binding pocket [chemical binding]; other site
479433011182	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
479433011183	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
479433011184	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433011185	sugar binding site [chemical binding]; other site
479433011186	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
479433011187	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433011188	sugar binding site [chemical binding]; other site
479433011189	Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182
479433011190	active site
479433011191	catalytic residues [active]
479433011192	Glucanosyltransferase; Region: Glyco_hydro_72; pfam03198
479433011193	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
479433011194	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433011195	sugar binding site [chemical binding]; other site
479433011196	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
479433011197	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
479433011198	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
479433011199	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433011200	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433011201	dimer interface [polypeptide binding]; other site
479433011202	conserved gate region; other site
479433011203	putative PBP binding loops; other site
479433011204	ABC-ATPase subunit interface; other site
479433011205	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433011206	dimer interface [polypeptide binding]; other site
479433011207	conserved gate region; other site
479433011208	putative PBP binding loops; other site
479433011209	ABC-ATPase subunit interface; other site
479433011210	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433011211	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
479433011212	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433011213	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433011214	DNA binding site [nucleotide binding]
479433011215	domain linker motif; other site
479433011216	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433011217	ligand binding site [chemical binding]; other site
479433011218	dimerization interface [polypeptide binding]; other site
479433011219	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663
479433011220	SxDxEG motif; other site
479433011221	active site
479433011222	metal binding site [ion binding]; metal-binding site
479433011223	homopentamer interface [polypeptide binding]; other site
479433011224	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433011225	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
479433011226	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
479433011227	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
479433011228	active site
479433011229	motif I; other site
479433011230	motif II; other site
479433011231	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
479433011232	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
479433011233	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
479433011234	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
479433011235	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_5; cd09621
479433011236	putative ligand binding site [chemical binding]; other site
479433011237	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
479433011238	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
479433011239	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
479433011240	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
479433011241	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
479433011242	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
479433011243	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321
479433011244	Moco binding site; other site
479433011245	metal coordination site [ion binding]; other site
479433011246	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
479433011247	[2Fe-2S] cluster binding site [ion binding]; other site
479433011248	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
479433011249	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
479433011250	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
479433011251	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
479433011252	substrate binding site [chemical binding]; other site
479433011253	THF binding site; other site
479433011254	zinc-binding site [ion binding]; other site
479433011255	Uncharacterized conserved protein [Function unknown]; Region: COG3391
479433011256	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
479433011257	Phosphoesterase family; Region: Phosphoesterase; pfam04185
479433011258	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
479433011259	putative metal binding site [ion binding]; other site
479433011260	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
479433011261	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
479433011262	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
479433011263	putative metal binding site [ion binding]; other site
479433011264	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433011265	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
479433011266	sugar binding site [chemical binding]; other site
479433011267	Coenzyme A transferase; Region: CoA_trans; cl17247
479433011268	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
479433011269	Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461
479433011270	chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465
479433011271	dimer interface [polypeptide binding]; other site
479433011272	active site
479433011273	Transcriptional regulators [Transcription]; Region: GntR; COG1802
479433011274	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433011275	DNA-binding site [nucleotide binding]; DNA binding site
479433011276	FCD domain; Region: FCD; pfam07729
479433011277	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
479433011278	putative active site [active]
479433011279	putative catalytic site [active]
479433011280	YCII-related domain; Region: YCII; cl00999
479433011281	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
479433011282	FAD binding domain; Region: FAD_binding_4; pfam01565
479433011283	Berberine and berberine like; Region: BBE; pfam08031
479433011284	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
479433011285	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433011286	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
479433011287	DNA binding residues [nucleotide binding]
479433011288	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
479433011289	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
479433011290	putative NAD(P) binding site [chemical binding]; other site
479433011291	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
479433011292	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433011293	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
479433011294	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
479433011295	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
479433011296	NAD(P) binding pocket [chemical binding]; other site
479433011297	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
479433011298	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
479433011299	putative DNA binding site [nucleotide binding]; other site
479433011300	putative Zn2+ binding site [ion binding]; other site
479433011301	AsnC family; Region: AsnC_trans_reg; pfam01037
479433011302	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
479433011303	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
479433011304	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433011305	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
479433011306	Walker A/P-loop; other site
479433011307	ATP binding site [chemical binding]; other site
479433011308	Q-loop/lid; other site
479433011309	ABC transporter signature motif; other site
479433011310	Walker B; other site
479433011311	D-loop; other site
479433011312	H-loop/switch region; other site
479433011313	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
479433011314	hypothetical protein; Provisional; Region: PRK07538
479433011315	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
479433011316	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433011317	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433011318	dimerization interface [polypeptide binding]; other site
479433011319	putative Zn2+ binding site [ion binding]; other site
479433011320	putative DNA binding site [nucleotide binding]; other site
479433011321	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433011322	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433011323	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
479433011324	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433011325	S-adenosylmethionine binding site [chemical binding]; other site
479433011326	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433011327	salt bridge; other site
479433011328	non-specific DNA binding site [nucleotide binding]; other site
479433011329	sequence-specific DNA binding site [nucleotide binding]; other site
479433011330	short chain dehydrogenase; Provisional; Region: PRK08263
479433011331	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
479433011332	NADP binding site [chemical binding]; other site
479433011333	active site
479433011334	steroid binding site; other site
479433011335	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
479433011336	Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200
479433011337	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433011338	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433011339	putative sugar binding sites [chemical binding]; other site
479433011340	Q-X-W motif; other site
479433011341	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433011342	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433011343	putative sugar binding sites [chemical binding]; other site
479433011344	Q-X-W motif; other site
479433011345	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
479433011346	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
479433011347	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
479433011348	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
479433011349	Walker A/P-loop; other site
479433011350	ATP binding site [chemical binding]; other site
479433011351	Q-loop/lid; other site
479433011352	ABC transporter signature motif; other site
479433011353	Walker B; other site
479433011354	D-loop; other site
479433011355	H-loop/switch region; other site
479433011356	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
479433011357	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
479433011358	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
479433011359	TM-ABC transporter signature motif; other site
479433011360	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
479433011361	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
479433011362	TM-ABC transporter signature motif; other site
479433011363	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433011364	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433011365	DNA binding site [nucleotide binding]
479433011366	domain linker motif; other site
479433011367	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433011368	dimerization interface [polypeptide binding]; other site
479433011369	ligand binding site [chemical binding]; other site
479433011370	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
479433011371	active site
479433011372	catalytic residues [active]
479433011373	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
479433011374	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433011375	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433011376	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
479433011377	active site clefts [active]
479433011378	zinc binding site [ion binding]; other site
479433011379	dimer interface [polypeptide binding]; other site
479433011380	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
479433011381	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
479433011382	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
479433011383	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433011384	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433011385	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
479433011386	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
479433011387	acyl-activating enzyme (AAE) consensus motif; other site
479433011388	putative AMP binding site [chemical binding]; other site
479433011389	putative active site [active]
479433011390	putative CoA binding site [chemical binding]; other site
479433011391	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433011392	putative substrate translocation pore; other site
479433011393	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433011394	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
479433011395	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433011396	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
479433011397	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820
479433011398	putative sugar binding sites [chemical binding]; other site
479433011399	Q-X-W motif; other site
479433011400	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
479433011401	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
479433011402	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313
479433011403	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
479433011404	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
479433011405	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
479433011406	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
479433011407	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
479433011408	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
479433011409	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
479433011410	phage tail protein domain; Region: tail_TIGR02242
479433011411	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
479433011412	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433011413	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433011414	DNA binding residues [nucleotide binding]
479433011415	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
479433011416	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
479433011417	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433011418	ATP binding site [chemical binding]; other site
479433011419	Walker A motif; other site
479433011420	Walker B motif; other site
479433011421	arginine finger; other site
479433011422	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
479433011423	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
479433011424	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
479433011425	iron-sulfur cluster [ion binding]; other site
479433011426	[2Fe-2S] cluster binding site [ion binding]; other site
479433011427	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
479433011428	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
479433011429	CGNR zinc finger; Region: zf-CGNR; pfam11706
479433011430	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
479433011431	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
479433011432	tetramerization interface [polypeptide binding]; other site
479433011433	NAD(P) binding site [chemical binding]; other site
479433011434	catalytic residues [active]
479433011435	malate dehydrogenase; Provisional; Region: PRK13529
479433011436	Malic enzyme, N-terminal domain; Region: malic; pfam00390
479433011437	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
479433011438	NAD(P) binding pocket [chemical binding]; other site
479433011439	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433011440	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
479433011441	active site
479433011442	L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases.  It is thought...; Region: LMO_FMN; cd03332
479433011443	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
479433011444	putative active site [active]
479433011445	putative substrate binding site [chemical binding]; other site
479433011446	putative FMN binding site [chemical binding]; other site
479433011447	putative catalytic residues [active]
479433011448	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433011449	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433011450	DNA binding site [nucleotide binding]
479433011451	domain linker motif; other site
479433011452	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433011453	dimerization interface [polypeptide binding]; other site
479433011454	ligand binding site [chemical binding]; other site
479433011455	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
479433011456	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
479433011457	metal binding site [ion binding]; metal-binding site
479433011458	substrate binding pocket [chemical binding]; other site
479433011459	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
479433011460	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433011461	NAD(P) binding site [chemical binding]; other site
479433011462	active site
479433011463	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
479433011464	hypothetical protein; Provisional; Region: PRK08609
479433011465	active site
479433011466	primer binding site [nucleotide binding]; other site
479433011467	NTP  binding site [chemical binding]; other site
479433011468	metal binding triad [ion binding]; metal-binding site
479433011469	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
479433011470	active site
479433011471	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
479433011472	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
479433011473	Cellulose binding domain; Region: CBM_2; pfam00553
479433011474	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433011475	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433011476	DNA binding site [nucleotide binding]
479433011477	domain linker motif; other site
479433011478	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
479433011479	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433011480	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
479433011481	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
479433011482	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433011483	dimer interface [polypeptide binding]; other site
479433011484	conserved gate region; other site
479433011485	putative PBP binding loops; other site
479433011486	ABC-ATPase subunit interface; other site
479433011487	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433011488	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433011489	putative PBP binding loops; other site
479433011490	dimer interface [polypeptide binding]; other site
479433011491	ABC-ATPase subunit interface; other site
479433011492	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433011493	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433011494	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
479433011495	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
479433011496	Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364
479433011497	Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542
479433011498	active site
479433011499	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
479433011500	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433011501	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433011502	hypothetical protein; Provisional; Region: PRK05463
479433011503	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433011504	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433011505	putative substrate translocation pore; other site
479433011506	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433011507	putative substrate translocation pore; other site
479433011508	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
479433011509	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
479433011510	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
479433011511	SnoaL-like domain; Region: SnoaL_2; pfam12680
479433011512	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
479433011513	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
479433011514	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
479433011515	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
479433011516	active site
479433011517	metal binding site [ion binding]; metal-binding site
479433011518	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
479433011519	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
479433011520	TIGR03084 family protein; Region: TIGR03084
479433011521	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
479433011522	Wyosine base formation; Region: Wyosine_form; pfam08608
479433011523	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
479433011524	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433011525	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433011526	active site
479433011527	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
479433011528	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
479433011529	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
479433011530	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
479433011531	ATP-grasp domain; Region: ATP-grasp_4; cl17255
479433011532	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
479433011533	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
479433011534	carboxyltransferase (CT) interaction site; other site
479433011535	biotinylation site [posttranslational modification]; other site
479433011536	enoyl-CoA hydratase; Provisional; Region: PRK07827
479433011537	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
479433011538	substrate binding site [chemical binding]; other site
479433011539	oxyanion hole (OAH) forming residues; other site
479433011540	trimer interface [polypeptide binding]; other site
479433011541	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433011542	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433011543	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
479433011544	Septum formation; Region: Septum_form; pfam13845
479433011545	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433011546	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433011547	DNA binding site [nucleotide binding]
479433011548	domain linker motif; other site
479433011549	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433011550	dimerization interface [polypeptide binding]; other site
479433011551	ligand binding site [chemical binding]; other site
479433011552	alpha-galactosidase; Region: PLN02808; cl17638
479433011553	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433011554	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
479433011555	Walker A/P-loop; other site
479433011556	ATP binding site [chemical binding]; other site
479433011557	Q-loop/lid; other site
479433011558	ABC transporter signature motif; other site
479433011559	Walker B; other site
479433011560	D-loop; other site
479433011561	H-loop/switch region; other site
479433011562	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
479433011563	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
479433011564	active site
479433011565	zinc binding site [ion binding]; other site
479433011566	SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830
479433011567	active site
479433011568	catalytic triad [active]
479433011569	oxyanion hole [active]
479433011570	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
479433011571	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
479433011572	ATP-grasp domain; Region: ATP-grasp_4; cl17255
479433011573	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
479433011574	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
479433011575	carboxyltransferase (CT) interaction site; other site
479433011576	biotinylation site [posttranslational modification]; other site
479433011577	Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326
479433011578	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
479433011579	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
479433011580	Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; cl17606
479433011581	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
479433011582	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
479433011583	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
479433011584	DNA binding site [nucleotide binding]
479433011585	active site
479433011586	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
479433011587	ligand-binding site [chemical binding]; other site
479433011588	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
479433011589	extended (e) SDRs; Region: SDR_e; cd08946
479433011590	NAD(P) binding site [chemical binding]; other site
479433011591	active site
479433011592	substrate binding site [chemical binding]; other site
479433011593	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
479433011594	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433011595	Coenzyme A binding pocket [chemical binding]; other site
479433011596	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
479433011597	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
479433011598	dimer interface [polypeptide binding]; other site
479433011599	active site
479433011600	heme binding site [chemical binding]; other site
479433011601	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
479433011602	heme binding site [chemical binding]; other site
479433011603	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
479433011604	metal binding site 2 [ion binding]; metal-binding site
479433011605	putative DNA binding helix; other site
479433011606	metal binding site 1 [ion binding]; metal-binding site
479433011607	dimer interface [polypeptide binding]; other site
479433011608	structural Zn2+ binding site [ion binding]; other site
479433011609	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433011610	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433011611	active site
479433011612	phosphorylation site [posttranslational modification]
479433011613	intermolecular recognition site; other site
479433011614	dimerization interface [polypeptide binding]; other site
479433011615	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433011616	DNA binding residues [nucleotide binding]
479433011617	Putative sensor; Region: Sensor; pfam13796
479433011618	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433011619	Histidine kinase; Region: HisKA_3; pfam07730
479433011620	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
479433011621	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
479433011622	Walker A/P-loop; other site
479433011623	ATP binding site [chemical binding]; other site
479433011624	Q-loop/lid; other site
479433011625	ABC transporter signature motif; other site
479433011626	Walker B; other site
479433011627	D-loop; other site
479433011628	H-loop/switch region; other site
479433011629	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
479433011630	FtsX-like permease family; Region: FtsX; pfam02687
479433011631	choline dehydrogenase; Validated; Region: PRK02106
479433011632	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
479433011633	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
479433011634	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
479433011635	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
479433011636	metal ion-dependent adhesion site (MIDAS); other site
479433011637	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
479433011638	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
479433011639	DNA binding residues [nucleotide binding]
479433011640	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
479433011641	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
479433011642	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433011643	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433011644	active site
479433011645	ATP binding site [chemical binding]; other site
479433011646	substrate binding site [chemical binding]; other site
479433011647	activation loop (A-loop); other site
479433011648	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
479433011649	PQQ-like domain; Region: PQQ_2; pfam13360
479433011650	Trp docking motif [polypeptide binding]; other site
479433011651	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
479433011652	active site
479433011653	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
479433011654	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433011655	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433011656	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433011657	binding surface
479433011658	TPR motif; other site
479433011659	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
479433011660	Isochorismatase family; Region: Isochorismatase; pfam00857
479433011661	catalytic triad [active]
479433011662	conserved cis-peptide bond; other site
479433011663	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
479433011664	classical (c) SDRs; Region: SDR_c; cd05233
479433011665	NAD(P) binding site [chemical binding]; other site
479433011666	active site
479433011667	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433011668	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433011669	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433011670	DNA binding residues [nucleotide binding]
479433011671	dimerization interface [polypeptide binding]; other site
479433011672	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433011673	Coenzyme A binding pocket [chemical binding]; other site
479433011674	elongation factor G; Reviewed; Region: PRK13351
479433011675	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
479433011676	G1 box; other site
479433011677	GTP/Mg2+ binding site [chemical binding]; other site
479433011678	G2 box; other site
479433011679	Switch I region; other site
479433011680	G3 box; other site
479433011681	Switch II region; other site
479433011682	G4 box; other site
479433011683	G5 box; other site
479433011684	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
479433011685	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
479433011686	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
479433011687	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
479433011688	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
479433011689	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
479433011690	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
479433011691	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
479433011692	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
479433011693	[4Fe-4S] binding site [ion binding]; other site
479433011694	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
479433011695	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
479433011696	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
479433011697	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
479433011698	molybdopterin cofactor binding site; other site
479433011699	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
479433011700	hydrophobic ligand binding site; other site
479433011701	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433011702	dimerization interface [polypeptide binding]; other site
479433011703	putative DNA binding site [nucleotide binding]; other site
479433011704	putative Zn2+ binding site [ion binding]; other site
479433011705	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
479433011706	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
479433011707	CoenzymeA binding site [chemical binding]; other site
479433011708	subunit interaction site [polypeptide binding]; other site
479433011709	PHB binding site; other site
479433011710	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
479433011711	active site
479433011712	SUMO-1 interface [polypeptide binding]; other site
479433011713	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433011714	Cytochrome P450; Region: p450; cl12078
479433011715	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
479433011716	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
479433011717	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
479433011718	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
479433011719	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
479433011720	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
479433011721	substrate binding site [chemical binding]; other site
479433011722	ATP binding site [chemical binding]; other site
479433011723	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
479433011724	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
479433011725	PYR/PP interface [polypeptide binding]; other site
479433011726	dimer interface [polypeptide binding]; other site
479433011727	TPP binding site [chemical binding]; other site
479433011728	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
479433011729	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
479433011730	TPP-binding site; other site
479433011731	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
479433011732	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
479433011733	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
479433011734	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
479433011735	TM-ABC transporter signature motif; other site
479433011736	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
479433011737	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
479433011738	Walker A/P-loop; other site
479433011739	ATP binding site [chemical binding]; other site
479433011740	Q-loop/lid; other site
479433011741	ABC transporter signature motif; other site
479433011742	Walker B; other site
479433011743	D-loop; other site
479433011744	H-loop/switch region; other site
479433011745	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
479433011746	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
479433011747	active site
479433011748	dimerization interface [polypeptide binding]; other site
479433011749	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433011750	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433011751	putative substrate translocation pore; other site
479433011752	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433011753	putative DNA binding site [nucleotide binding]; other site
479433011754	dimerization interface [polypeptide binding]; other site
479433011755	putative Zn2+ binding site [ion binding]; other site
479433011756	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
479433011757	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
479433011758	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
479433011759	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433011760	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
479433011761	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
479433011762	putative DNA binding site [nucleotide binding]; other site
479433011763	catalytic residue [active]
479433011764	putative H2TH interface [polypeptide binding]; other site
479433011765	putative catalytic residues [active]
479433011766	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
479433011767	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
479433011768	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
479433011769	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
479433011770	EamA-like transporter family; Region: EamA; pfam00892
479433011771	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433011772	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433011773	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
479433011774	putative dimerization interface [polypeptide binding]; other site
479433011775	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
479433011776	acetyl-CoA synthetase; Provisional; Region: PRK00174
479433011777	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
479433011778	active site
479433011779	CoA binding site [chemical binding]; other site
479433011780	acyl-activating enzyme (AAE) consensus motif; other site
479433011781	AMP binding site [chemical binding]; other site
479433011782	acetate binding site [chemical binding]; other site
479433011783	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
479433011784	ArsC family; Region: ArsC; pfam03960
479433011785	catalytic residues [active]
479433011786	DinB superfamily; Region: DinB_2; pfam12867
479433011787	Helix-turn-helix domain; Region: HTH_18; pfam12833
479433011788	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
479433011789	TIGR03086 family protein; Region: TIGR03086
479433011790	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
479433011791	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
479433011792	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
479433011793	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433011794	Coenzyme A binding pocket [chemical binding]; other site
479433011795	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433011796	Coenzyme A binding pocket [chemical binding]; other site
479433011797	Beta-lactamase; Region: Beta-lactamase; pfam00144
479433011798	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
479433011799	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
479433011800	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
479433011801	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
479433011802	putative active site [active]
479433011803	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
479433011804	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
479433011805	putative active site [active]
479433011806	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
479433011807	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
479433011808	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
479433011809	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433011810	putative PBP binding loops; other site
479433011811	dimer interface [polypeptide binding]; other site
479433011812	ABC-ATPase subunit interface; other site
479433011813	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
479433011814	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433011815	dimer interface [polypeptide binding]; other site
479433011816	conserved gate region; other site
479433011817	putative PBP binding loops; other site
479433011818	ABC-ATPase subunit interface; other site
479433011819	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433011820	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
479433011821	Walker A/P-loop; other site
479433011822	ATP binding site [chemical binding]; other site
479433011823	Q-loop/lid; other site
479433011824	ABC transporter signature motif; other site
479433011825	Walker B; other site
479433011826	D-loop; other site
479433011827	H-loop/switch region; other site
479433011828	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
479433011829	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
479433011830	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433011831	Walker A/P-loop; other site
479433011832	ATP binding site [chemical binding]; other site
479433011833	Q-loop/lid; other site
479433011834	ABC transporter signature motif; other site
479433011835	Walker B; other site
479433011836	D-loop; other site
479433011837	H-loop/switch region; other site
479433011838	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
479433011839	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
479433011840	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
479433011841	dimer interface [polypeptide binding]; other site
479433011842	catalytic triad [active]
479433011843	Protein of unknown function (DUF779); Region: DUF779; pfam05610
479433011844	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
479433011845	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
479433011846	NAD(P) binding site [chemical binding]; other site
479433011847	catalytic residues [active]
479433011848	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433011849	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
479433011850	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
479433011851	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
479433011852	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433011853	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433011854	active site
479433011855	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433011856	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433011857	ATP binding site [chemical binding]; other site
479433011858	Mg2+ binding site [ion binding]; other site
479433011859	G-X-G motif; other site
479433011860	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
479433011861	anti sigma factor interaction site; other site
479433011862	regulatory phosphorylation site [posttranslational modification]; other site
479433011863	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
479433011864	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
479433011865	iron-sulfur cluster [ion binding]; other site
479433011866	[2Fe-2S] cluster binding site [ion binding]; other site
479433011867	Protein of unknown function, DUF488; Region: DUF488; pfam04343
479433011868	Hemerythrin-like domain; Region: Hr-like; cd12108
479433011869	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
479433011870	[4Fe-4S] binding site [ion binding]; other site
479433011871	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
479433011872	molybdopterin cofactor binding site; other site
479433011873	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
479433011874	molybdopterin cofactor binding site; other site
479433011875	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433011876	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433011877	active site
479433011878	ATP binding site [chemical binding]; other site
479433011879	substrate binding site [chemical binding]; other site
479433011880	activation loop (A-loop); other site
479433011881	Isochorismatase family; Region: Isochorismatase; pfam00857
479433011882	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
479433011883	catalytic triad [active]
479433011884	conserved cis-peptide bond; other site
479433011885	AzlC protein; Region: AzlC; pfam03591
479433011886	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433011887	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433011888	sequence-specific DNA binding site [nucleotide binding]; other site
479433011889	salt bridge; other site
479433011890	Cupin domain; Region: Cupin_2; cl17218
479433011891	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
479433011892	Methyltransferase domain; Region: Methyltransf_23; pfam13489
479433011893	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433011894	S-adenosylmethionine binding site [chemical binding]; other site
479433011895	Acyltransferase family; Region: Acyl_transf_3; pfam01757
479433011896	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
479433011897	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
479433011898	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433011899	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
479433011900	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
479433011901	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
479433011902	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
479433011903	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433011904	Walker A/P-loop; other site
479433011905	ATP binding site [chemical binding]; other site
479433011906	Q-loop/lid; other site
479433011907	ABC transporter signature motif; other site
479433011908	Walker B; other site
479433011909	D-loop; other site
479433011910	H-loop/switch region; other site
479433011911	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
479433011912	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
479433011913	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433011914	Walker A/P-loop; other site
479433011915	ATP binding site [chemical binding]; other site
479433011916	Q-loop/lid; other site
479433011917	ABC transporter signature motif; other site
479433011918	Walker B; other site
479433011919	D-loop; other site
479433011920	H-loop/switch region; other site
479433011921	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
479433011922	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
479433011923	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433011924	dimer interface [polypeptide binding]; other site
479433011925	conserved gate region; other site
479433011926	putative PBP binding loops; other site
479433011927	ABC-ATPase subunit interface; other site
479433011928	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
479433011929	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
479433011930	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433011931	dimer interface [polypeptide binding]; other site
479433011932	conserved gate region; other site
479433011933	putative PBP binding loops; other site
479433011934	ABC-ATPase subunit interface; other site
479433011935	The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506
479433011936	peptide binding site [polypeptide binding]; other site
479433011937	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
479433011938	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
479433011939	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433011940	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
479433011941	short chain dehydrogenase; Provisional; Region: PRK07041
479433011942	putative NAD(P) binding site [chemical binding]; other site
479433011943	homodimer interface [polypeptide binding]; other site
479433011944	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433011945	Coenzyme A binding pocket [chemical binding]; other site
479433011946	Cupin domain; Region: Cupin_2; pfam07883
479433011947	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
479433011948	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
479433011949	DNA binding residues [nucleotide binding]
479433011950	putative dimer interface [polypeptide binding]; other site
479433011951	cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662
479433011952	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433011953	NAD(P) binding site [chemical binding]; other site
479433011954	active site
479433011955	MarR family; Region: MarR_2; pfam12802
479433011956	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
479433011957	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
479433011958	nudix motif; other site
479433011959	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
479433011960	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
479433011961	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
479433011962	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
479433011963	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
479433011964	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
479433011965	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
479433011966	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433011967	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433011968	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433011969	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
479433011970	putative NAD(P) binding site [chemical binding]; other site
479433011971	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
479433011972	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433011973	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433011974	dimerization interface [polypeptide binding]; other site
479433011975	DNA binding residues [nucleotide binding]
479433011976	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433011977	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
479433011978	Coenzyme A binding pocket [chemical binding]; other site
479433011979	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
479433011980	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433011981	Coenzyme A binding pocket [chemical binding]; other site
479433011982	YCII-related domain; Region: YCII; cl00999
479433011983	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
479433011984	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433011985	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433011986	putative substrate translocation pore; other site
479433011987	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433011988	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433011989	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433011990	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433011991	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433011992	Methyltransferase domain; Region: Methyltransf_31; pfam13847
479433011993	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433011994	S-adenosylmethionine binding site [chemical binding]; other site
479433011995	Smr domain; Region: Smr; pfam01713
479433011996	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
479433011997	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
479433011998	potential catalytic triad [active]
479433011999	conserved cys residue [active]
479433012000	Predicted membrane protein [Function unknown]; Region: COG4325
479433012001	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
479433012002	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
479433012003	Protein of unknown function (DUF952); Region: DUF952; pfam06108
479433012004	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
479433012005	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
479433012006	Substrate binding site; other site
479433012007	Cupin domain; Region: Cupin_2; cl17218
479433012008	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
479433012009	NlpC/P60 family; Region: NLPC_P60; pfam00877
479433012010	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
479433012011	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
479433012012	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
479433012013	biotin synthase; Validated; Region: PRK06256
479433012014	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433012015	FeS/SAM binding site; other site
479433012016	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
479433012017	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433012018	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
479433012019	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433012020	dimerization interface [polypeptide binding]; other site
479433012021	putative Zn2+ binding site [ion binding]; other site
479433012022	putative DNA binding site [nucleotide binding]; other site
479433012023	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433012024	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433012025	acyl-activating enzyme (AAE) consensus motif; other site
479433012026	AMP binding site [chemical binding]; other site
479433012027	active site
479433012028	CoA binding site [chemical binding]; other site
479433012029	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433012030	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
479433012031	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
479433012032	putative CoA binding site [chemical binding]; other site
479433012033	putative trimer interface [polypeptide binding]; other site
479433012034	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
479433012035	putative trimer interface [polypeptide binding]; other site
479433012036	putative CoA binding site [chemical binding]; other site
479433012037	Peptidase family M1; Region: Peptidase_M1; pfam01433
479433012038	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
479433012039	Zn binding site [ion binding]; other site
479433012040	Pirin-related protein [General function prediction only]; Region: COG1741
479433012041	Pirin; Region: Pirin; pfam02678
479433012042	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
479433012043	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
479433012044	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433012045	S-adenosylmethionine binding site [chemical binding]; other site
479433012046	TIGR03085 family protein; Region: TIGR03085
479433012047	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
479433012048	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
479433012049	putative catalytic site [active]
479433012050	putative phosphate binding site [ion binding]; other site
479433012051	active site
479433012052	metal binding site A [ion binding]; metal-binding site
479433012053	DNA binding site [nucleotide binding]
479433012054	putative AP binding site [nucleotide binding]; other site
479433012055	putative metal binding site B [ion binding]; other site
479433012056	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
479433012057	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
479433012058	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433012059	Coenzyme A binding pocket [chemical binding]; other site
479433012060	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
479433012061	substrate binding pocket [chemical binding]; other site
479433012062	substrate-Mg2+ binding site; other site
479433012063	aspartate-rich region 1; other site
479433012064	aspartate-rich region 2; other site
479433012065	tocopherol O-methyltransferase; Region: PLN02244
479433012066	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433012067	S-adenosylmethionine binding site [chemical binding]; other site
479433012068	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
479433012069	aspartate-rich region 2; other site
479433012070	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
479433012071	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
479433012072	ligand binding site [chemical binding]; other site
479433012073	flexible hinge region; other site
479433012074	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433012075	MarR family; Region: MarR; pfam01047
479433012076	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433012077	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
479433012078	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
479433012079	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
479433012080	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
479433012081	active site
479433012082	DNA binding site [nucleotide binding]
479433012083	Int/Topo IB signature motif; other site
479433012084	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433012085	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433012086	active site
479433012087	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433012088	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433012089	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
479433012090	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
479433012091	NodB motif; other site
479433012092	active site
479433012093	catalytic site [active]
479433012094	metal binding site [ion binding]; metal-binding site
479433012095	putative CoA-transferase; Provisional; Region: PRK11430
479433012096	CoA-transferase family III; Region: CoA_transf_3; pfam02515
479433012097	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
479433012098	NRDE protein; Region: NRDE; cl01315
479433012099	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433012100	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
479433012101	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
479433012102	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
479433012103	metal binding site [ion binding]; metal-binding site
479433012104	active site
479433012105	I-site; other site
479433012106	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
479433012107	I-site; other site
479433012108	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
479433012109	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
479433012110	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433012111	Coenzyme A binding pocket [chemical binding]; other site
479433012112	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
479433012113	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
479433012114	active site
479433012115	HIGH motif; other site
479433012116	dimer interface [polypeptide binding]; other site
479433012117	KMSKS motif; other site
479433012118	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
479433012119	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433012120	active site
479433012121	metal binding site [ion binding]; metal-binding site
479433012122	Uncharacterized conserved protein [Function unknown]; Region: COG2128
479433012123	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
479433012124	alpha-galactosidase; Region: PLN02808; cl17638
479433012125	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433012126	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433012127	putative sugar binding sites [chemical binding]; other site
479433012128	Q-X-W motif; other site
479433012129	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
479433012130	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
479433012131	Predicted transcriptional regulators [Transcription]; Region: COG1733
479433012132	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
479433012133	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433012134	NAD(P) binding site [chemical binding]; other site
479433012135	active site
479433012136	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
479433012137	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433012138	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433012139	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
479433012140	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433012141	NAD(P) binding site [chemical binding]; other site
479433012142	active site
479433012143	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
479433012144	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
479433012145	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
479433012146	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
479433012147	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
479433012148	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
479433012149	putative DNA binding site [nucleotide binding]; other site
479433012150	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
479433012151	putative Zn2+ binding site [ion binding]; other site
479433012152	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433012153	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
479433012154	nucleotide binding site [chemical binding]; other site
479433012155	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433012156	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433012157	putative substrate translocation pore; other site
479433012158	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433012159	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433012160	putative sugar binding sites [chemical binding]; other site
479433012161	Q-X-W motif; other site
479433012162	Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325
479433012163	putative sugar binding site [chemical binding]; other site
479433012164	catalytic residues [active]
479433012165	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433012166	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
479433012167	Walker A/P-loop; other site
479433012168	ATP binding site [chemical binding]; other site
479433012169	Q-loop/lid; other site
479433012170	ABC transporter signature motif; other site
479433012171	Walker B; other site
479433012172	D-loop; other site
479433012173	H-loop/switch region; other site
479433012174	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
479433012175	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
479433012176	AAA ATPase domain; Region: AAA_16; pfam13191
479433012177	Predicted ATPase [General function prediction only]; Region: COG3903
479433012178	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
479433012179	putative metal binding site [ion binding]; other site
479433012180	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
479433012181	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433012182	salt bridge; other site
479433012183	non-specific DNA binding site [nucleotide binding]; other site
479433012184	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433012185	sequence-specific DNA binding site [nucleotide binding]; other site
479433012186	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
479433012187	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433012188	NAD(P) binding site [chemical binding]; other site
479433012189	active site
479433012190	Predicted membrane protein [Function unknown]; Region: COG1289
479433012191	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
479433012192	short chain dehydrogenase; Provisional; Region: PRK12937
479433012193	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
479433012194	NADP binding site [chemical binding]; other site
479433012195	homodimer interface [polypeptide binding]; other site
479433012196	active site
479433012197	substrate binding site [chemical binding]; other site
479433012198	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
479433012199	NADP binding site [chemical binding]; other site
479433012200	active site
479433012201	steroid binding site; other site
479433012202	Tautomerase enzyme; Region: Tautomerase; pfam01361
479433012203	active site 1 [active]
479433012204	dimer interface [polypeptide binding]; other site
479433012205	hexamer interface [polypeptide binding]; other site
479433012206	active site 2 [active]
479433012207	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
479433012208	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433012209	AAA ATPase domain; Region: AAA_16; pfam13191
479433012210	Predicted ATPase [General function prediction only]; Region: COG3903
479433012211	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
479433012212	intersubunit interface [polypeptide binding]; other site
479433012213	active site
479433012214	catalytic residue [active]
479433012215	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
479433012216	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433012217	DNA-binding site [nucleotide binding]; DNA binding site
479433012218	UTRA domain; Region: UTRA; pfam07702
479433012219	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
479433012220	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
479433012221	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433012222	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433012223	DNA binding site [nucleotide binding]
479433012224	domain linker motif; other site
479433012225	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433012226	dimerization interface [polypeptide binding]; other site
479433012227	ligand binding site [chemical binding]; other site
479433012228	Condensation domain; Region: Condensation; pfam00668
479433012229	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
479433012230	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
479433012231	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433012232	NAD(P) binding site [chemical binding]; other site
479433012233	active site
479433012234	Predicted transcriptional regulators [Transcription]; Region: COG1733
479433012235	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
479433012236	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433012237	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433012238	DNA binding site [nucleotide binding]
479433012239	domain linker motif; other site
479433012240	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433012241	dimerization interface [polypeptide binding]; other site
479433012242	ligand binding site [chemical binding]; other site
479433012243	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
479433012244	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
479433012245	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
479433012246	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
479433012247	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
479433012248	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
479433012249	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433012250	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433012251	dimer interface [polypeptide binding]; other site
479433012252	conserved gate region; other site
479433012253	putative PBP binding loops; other site
479433012254	ABC-ATPase subunit interface; other site
479433012255	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
479433012256	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433012257	dimer interface [polypeptide binding]; other site
479433012258	conserved gate region; other site
479433012259	ABC-ATPase subunit interface; other site
479433012260	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433012261	putative alpha-glucosidase; Provisional; Region: PRK10658
479433012262	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
479433012263	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
479433012264	active site
479433012265	homotrimer interface [polypeptide binding]; other site
479433012266	catalytic site [active]
479433012267	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
479433012268	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
479433012269	Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317
479433012270	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
479433012271	active site
479433012272	Ca binding site [ion binding]; other site
479433012273	catalytic site [active]
479433012274	Aamy_C domain; Region: Aamy_C; smart00632
479433012275	Starch binding domain; Region: CBM_20; pfam00686
479433012276	starch-binding site 2 [chemical binding]; other site
479433012277	starch-binding site 1 [chemical binding]; other site
479433012278	Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808
479433012279	starch-binding site 2 [chemical binding]; other site
479433012280	starch-binding site 1 [chemical binding]; other site
479433012281	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
479433012282	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433012283	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
479433012284	nucleotide binding site [chemical binding]; other site
479433012285	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
479433012286	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433012287	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
479433012288	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
479433012289	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433012290	ABC-ATPase subunit interface; other site
479433012291	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433012292	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433012293	dimer interface [polypeptide binding]; other site
479433012294	conserved gate region; other site
479433012295	putative PBP binding loops; other site
479433012296	ABC-ATPase subunit interface; other site
479433012297	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
479433012298	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
479433012299	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
479433012300	Spherulation-specific family 4; Region: Spherulin4; pfam12138
479433012301	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
479433012302	Interdomain contacts; other site
479433012303	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
479433012304	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
479433012305	substrate binding site [chemical binding]; other site
479433012306	ATP binding site [chemical binding]; other site
479433012307	alpha-galactosidase; Provisional; Region: PRK15076
479433012308	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
479433012309	NAD(P) binding site [chemical binding]; other site
479433012310	LDH/MDH dimer interface [polypeptide binding]; other site
479433012311	substrate binding site [chemical binding]; other site
479433012312	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
479433012313	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
479433012314	dimer interface [polypeptide binding]; other site
479433012315	active site
479433012316	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
479433012317	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433012318	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433012319	dimer interface [polypeptide binding]; other site
479433012320	conserved gate region; other site
479433012321	putative PBP binding loops; other site
479433012322	ABC-ATPase subunit interface; other site
479433012323	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433012324	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433012325	dimer interface [polypeptide binding]; other site
479433012326	conserved gate region; other site
479433012327	putative PBP binding loops; other site
479433012328	ABC-ATPase subunit interface; other site
479433012329	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
479433012330	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
479433012331	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
479433012332	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
479433012333	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
479433012334	TM1410 hypothetical-related protein; Region: DUF297; pfam03537
479433012335	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
479433012336	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
479433012337	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
479433012338	TM-ABC transporter signature motif; other site
479433012339	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
479433012340	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
479433012341	Walker A/P-loop; other site
479433012342	ATP binding site [chemical binding]; other site
479433012343	Q-loop/lid; other site
479433012344	ABC transporter signature motif; other site
479433012345	Walker B; other site
479433012346	D-loop; other site
479433012347	H-loop/switch region; other site
479433012348	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
479433012349	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
479433012350	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
479433012351	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433012352	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433012353	DNA binding site [nucleotide binding]
479433012354	domain linker motif; other site
479433012355	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
479433012356	ligand binding site [chemical binding]; other site
479433012357	dimerization interface (open form) [polypeptide binding]; other site
479433012358	dimerization interface (closed form) [polypeptide binding]; other site
479433012359	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
479433012360	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433012361	Coenzyme A binding pocket [chemical binding]; other site
479433012362	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
479433012363	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
479433012364	active site
479433012365	I-site; other site
479433012366	metal binding site [ion binding]; metal-binding site
479433012367	AAA ATPase domain; Region: AAA_16; pfam13191
479433012368	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433012369	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433012370	DNA binding residues [nucleotide binding]
479433012371	maltose O-acetyltransferase; Provisional; Region: PRK10092
479433012372	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
479433012373	trimer interface [polypeptide binding]; other site
479433012374	active site
479433012375	substrate binding site [chemical binding]; other site
479433012376	CoA binding site [chemical binding]; other site
479433012377	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
479433012378	active site
479433012379	catalytic triad [active]
479433012380	calcium binding site [ion binding]; other site
479433012381	L-arabinose isomerase; Provisional; Region: PRK02929
479433012382	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
479433012383	hexamer (dimer of trimers) interface [polypeptide binding]; other site
479433012384	trimer interface [polypeptide binding]; other site
479433012385	substrate binding site [chemical binding]; other site
479433012386	Mn binding site [ion binding]; other site
479433012387	L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557
479433012388	intersubunit interface [polypeptide binding]; other site
479433012389	active site
479433012390	Zn2+ binding site [ion binding]; other site
479433012391	ribulokinase; Provisional; Region: PRK04123
479433012392	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
479433012393	nucleotide binding site [chemical binding]; other site
479433012394	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433012395	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433012396	DNA binding site [nucleotide binding]
479433012397	domain linker motif; other site
479433012398	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
479433012399	ligand binding site [chemical binding]; other site
479433012400	dimerization interface (open form) [polypeptide binding]; other site
479433012401	dimerization interface (closed form) [polypeptide binding]; other site
479433012402	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
479433012403	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
479433012404	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
479433012405	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
479433012406	TM-ABC transporter signature motif; other site
479433012407	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
479433012408	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
479433012409	Walker A/P-loop; other site
479433012410	ATP binding site [chemical binding]; other site
479433012411	Q-loop/lid; other site
479433012412	ABC transporter signature motif; other site
479433012413	Walker B; other site
479433012414	D-loop; other site
479433012415	H-loop/switch region; other site
479433012416	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
479433012417	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
479433012418	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
479433012419	putative ligand binding site [chemical binding]; other site
479433012420	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433012421	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433012422	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433012423	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
479433012424	putative dimerization interface [polypeptide binding]; other site
479433012425	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
479433012426	xanthine permease; Region: pbuX; TIGR03173
479433012427	allantoicase; Provisional; Region: PRK13257
479433012428	Allantoicase repeat; Region: Allantoicase; pfam03561
479433012429	Allantoicase repeat; Region: Allantoicase; pfam03561
479433012430	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
479433012431	allantoinase; Region: allantoinase; TIGR03178
479433012432	active site
479433012433	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
479433012434	Glycerate kinase family; Region: Gly_kinase; cl00841
479433012435	glyoxylate carboligase; Provisional; Region: PRK11269
479433012436	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
479433012437	PYR/PP interface [polypeptide binding]; other site
479433012438	dimer interface [polypeptide binding]; other site
479433012439	TPP binding site [chemical binding]; other site
479433012440	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
479433012441	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
479433012442	TPP-binding site [chemical binding]; other site
479433012443	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
479433012444	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
479433012445	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
479433012446	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
479433012447	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
479433012448	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
479433012449	XdhC Rossmann domain; Region: XdhC_C; pfam13478
479433012450	xanthine dehydrogenase D subunit; Region: pucD; TIGR03196
479433012451	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
479433012452	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
479433012453	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
479433012454	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
479433012455	active site
479433012456	putative substrate binding pocket [chemical binding]; other site
479433012457	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
479433012458	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
479433012459	catalytic loop [active]
479433012460	iron binding site [ion binding]; other site
479433012461	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
479433012462	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
479433012463	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
479433012464	urate oxidase; Region: urate_oxi; TIGR03383
479433012465	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
479433012466	active site
479433012467	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
479433012468	active site
479433012469	homotetramer interface [polypeptide binding]; other site
479433012470	putative OHCU decarboxylase; Provisional; Region: PRK13798
479433012471	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
479433012472	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
479433012473	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
479433012474	metal-binding site
479433012475	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
479433012476	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
479433012477	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
479433012478	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
479433012479	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
479433012480	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
479433012481	Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706
479433012482	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
479433012483	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433012484	YCII-related domain; Region: YCII; cl00999
479433012485	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
479433012486	putative dimer interface [polypeptide binding]; other site
479433012487	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433012488	DoxX-like family; Region: DoxX_2; pfam13564
479433012489	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
479433012490	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433012491	S-adenosylmethionine binding site [chemical binding]; other site
479433012492	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
479433012493	NADH(P)-binding; Region: NAD_binding_10; pfam13460
479433012494	NAD binding site [chemical binding]; other site
479433012495	substrate binding site [chemical binding]; other site
479433012496	putative active site [active]
479433012497	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433012498	dimerization interface [polypeptide binding]; other site
479433012499	putative DNA binding site [nucleotide binding]; other site
479433012500	putative Zn2+ binding site [ion binding]; other site
479433012501	Septum formation topological specificity factor MinE; Region: MinE; cl00538
479433012502	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
479433012503	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
479433012504	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
479433012505	nucleotide binding site [chemical binding]; other site
479433012506	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
479433012507	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433012508	NAD(P) binding site [chemical binding]; other site
479433012509	active site
479433012510	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
479433012511	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433012512	NAD(P) binding site [chemical binding]; other site
479433012513	active site
479433012514	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
479433012515	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433012516	S-adenosylmethionine binding site [chemical binding]; other site
479433012517	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
479433012518	active site
479433012519	DNA binding site [nucleotide binding]
479433012520	Int/Topo IB signature motif; other site
479433012521	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
479433012522	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433012523	MarR family; Region: MarR_2; cl17246
479433012524	EamA-like transporter family; Region: EamA; pfam00892
479433012525	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
479433012526	EamA-like transporter family; Region: EamA; pfam00892
479433012527	Uncharacterized conserved protein [Function unknown]; Region: COG3268
479433012528	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433012529	NAD(P) binding site [chemical binding]; other site
479433012530	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
479433012531	substrate binding site [chemical binding]; other site
479433012532	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
479433012533	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
479433012534	active site
479433012535	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
479433012536	catalytic triad [active]
479433012537	dimer interface [polypeptide binding]; other site
479433012538	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
479433012539	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
479433012540	putative acyl-acceptor binding pocket; other site
479433012541	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
479433012542	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433012543	binding surface
479433012544	TPR motif; other site
479433012545	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
479433012546	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433012547	CAAX protease self-immunity; Region: Abi; pfam02517
479433012548	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
479433012549	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
479433012550	metal ion-dependent adhesion site (MIDAS); other site
479433012551	Phosphotransferase enzyme family; Region: APH; pfam01636
479433012552	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
479433012553	substrate binding site [chemical binding]; other site
479433012554	glycine dehydrogenase; Provisional; Region: PRK05367
479433012555	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
479433012556	tetramer interface [polypeptide binding]; other site
479433012557	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433012558	catalytic residue [active]
479433012559	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
479433012560	tetramer interface [polypeptide binding]; other site
479433012561	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433012562	catalytic residue [active]
479433012563	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
479433012564	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433012565	Coenzyme A binding pocket [chemical binding]; other site
479433012566	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
479433012567	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
479433012568	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433012569	Coenzyme A binding pocket [chemical binding]; other site
479433012570	Ribosomal protein L21e; Region: Ribosomal_L21e; cl00937
479433012571	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
479433012572	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
479433012573	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
479433012574	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433012575	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433012576	active site
479433012577	catalytic tetrad [active]
479433012578	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
479433012579	active site
479433012580	oxyanion hole [active]
479433012581	catalytic triad [active]
479433012582	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
479433012583	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433012584	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433012585	active site
479433012586	ATP binding site [chemical binding]; other site
479433012587	substrate binding site [chemical binding]; other site
479433012588	activation loop (A-loop); other site
479433012589	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433012590	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
479433012591	Family of unknown function (DUF695); Region: DUF695; pfam05117
479433012592	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
479433012593	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
479433012594	FAD binding domain; Region: FAD_binding_4; pfam01565
479433012595	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
479433012596	Cysteine-rich domain; Region: CCG; pfam02754
479433012597	Cysteine-rich domain; Region: CCG; pfam02754
479433012598	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
479433012599	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433012600	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
479433012601	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
479433012602	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
479433012603	Walker A/P-loop; other site
479433012604	ATP binding site [chemical binding]; other site
479433012605	Q-loop/lid; other site
479433012606	ABC transporter signature motif; other site
479433012607	Walker B; other site
479433012608	D-loop; other site
479433012609	H-loop/switch region; other site
479433012610	Predicted transcriptional regulators [Transcription]; Region: COG1695
479433012611	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
479433012612	Rrf2 family protein; Region: rrf2_super; TIGR00738
479433012613	Transcriptional regulator; Region: Rrf2; pfam02082
479433012614	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
479433012615	A subgroup of  the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568
479433012616	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
479433012617	active site
479433012618	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
479433012619	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
479433012620	Nitrogen regulatory protein P-II; Region: P-II; smart00938
479433012621	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433012622	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433012623	putative sugar binding sites [chemical binding]; other site
479433012624	Q-X-W motif; other site
479433012625	AAA ATPase domain; Region: AAA_16; pfam13191
479433012626	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433012627	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433012628	DNA binding residues [nucleotide binding]
479433012629	dimerization interface [polypeptide binding]; other site
479433012630	acyl-CoA synthetase; Validated; Region: PRK07788
479433012631	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433012632	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433012633	acyl-activating enzyme (AAE) consensus motif; other site
479433012634	AMP binding site [chemical binding]; other site
479433012635	active site
479433012636	CoA binding site [chemical binding]; other site
479433012637	acyl-CoA synthetase; Validated; Region: PRK07788
479433012638	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433012639	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
479433012640	acyl-activating enzyme (AAE) consensus motif; other site
479433012641	acyl-activating enzyme (AAE) consensus motif; other site
479433012642	putative AMP binding site [chemical binding]; other site
479433012643	putative active site [active]
479433012644	putative CoA binding site [chemical binding]; other site
479433012645	Lipase (class 2); Region: Lipase_2; pfam01674
479433012646	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
479433012647	AAA domain; Region: AAA_33; pfam13671
479433012648	AAA domain; Region: AAA_17; pfam13207
479433012649	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
479433012650	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
479433012651	tetramer interface [polypeptide binding]; other site
479433012652	active site
479433012653	Mg2+/Mn2+ binding site [ion binding]; other site
479433012654	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
479433012655	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433012656	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
479433012657	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433012658	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433012659	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433012660	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433012661	putative substrate translocation pore; other site
479433012662	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433012663	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
479433012664	active site
479433012665	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433012666	SCP-2 sterol transfer family; Region: SCP2; pfam02036
479433012667	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
479433012668	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
479433012669	active site 2 [active]
479433012670	active site 1 [active]
479433012671	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
479433012672	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433012673	NAD(P) binding site [chemical binding]; other site
479433012674	active site
479433012675	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433012676	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433012677	active site
479433012678	catalytic tetrad [active]
479433012679	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433012680	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433012681	active site
479433012682	ATP binding site [chemical binding]; other site
479433012683	substrate binding site [chemical binding]; other site
479433012684	activation loop (A-loop); other site
479433012685	transketolase; Reviewed; Region: PRK05899
479433012686	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
479433012687	TPP-binding site [chemical binding]; other site
479433012688	dimer interface [polypeptide binding]; other site
479433012689	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
479433012690	PYR/PP interface [polypeptide binding]; other site
479433012691	dimer interface [polypeptide binding]; other site
479433012692	TPP binding site [chemical binding]; other site
479433012693	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
479433012694	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
479433012695	Multisubunit Na+/H+ antiporter, MnhC subunit [Inorganic ion transport and metabolism]; Region: MnhC; COG1006
479433012696	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
479433012697	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
479433012698	Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320
479433012699	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
479433012700	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
479433012701	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
479433012702	putative hydrophobic ligand binding site [chemical binding]; other site
479433012703	Hemerythrin-like domain; Region: Hr-like; cd12108
479433012704	Fe binding site [ion binding]; other site
479433012705	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
479433012706	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433012707	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
479433012708	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433012709	DNA binding residues [nucleotide binding]
479433012710	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
479433012711	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433012712	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
479433012713	anti sigma factor interaction site; other site
479433012714	regulatory phosphorylation site [posttranslational modification]; other site
479433012715	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
479433012716	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
479433012717	motif II; other site
479433012718	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
479433012719	F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557
479433012720	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
479433012721	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
479433012722	phosphate binding site [ion binding]; other site
479433012723	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433012724	F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557
479433012725	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
479433012726	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
479433012727	anti sigma factor interaction site; other site
479433012728	regulatory phosphorylation site [posttranslational modification]; other site
479433012729	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433012730	MarR family; Region: MarR_2; pfam12802
479433012731	thiamine pyrophosphate protein; Provisional; Region: PRK08273
479433012732	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
479433012733	PYR/PP interface [polypeptide binding]; other site
479433012734	dimer interface [polypeptide binding]; other site
479433012735	tetramer interface [polypeptide binding]; other site
479433012736	TPP binding site [chemical binding]; other site
479433012737	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
479433012738	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
479433012739	TPP-binding site [chemical binding]; other site
479433012740	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
479433012741	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
479433012742	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
479433012743	FAD binding domain; Region: FAD_binding_4; pfam01565
479433012744	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
479433012745	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
479433012746	catalytic core [active]
479433012747	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
479433012748	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
479433012749	Predicted transcriptional regulators [Transcription]; Region: COG1695
479433012750	Transcriptional regulator PadR-like family; Region: PadR; cl17335
479433012751	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
479433012752	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
479433012753	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
479433012754	hypothetical protein; Provisional; Region: PRK07945
479433012755	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
479433012756	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
479433012757	active site
479433012758	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
479433012759	F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557
479433012760	Hemerythrin-like domain; Region: Hr-like; cd12108
479433012761	Fe binding site [ion binding]; other site
479433012762	short chain dehydrogenase; Provisional; Region: PRK12828
479433012763	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433012764	NAD(P) binding site [chemical binding]; other site
479433012765	active site
479433012766	Condensation domain; Region: Condensation; pfam00668
479433012767	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
479433012768	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
479433012769	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433012770	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433012771	putative sugar binding sites [chemical binding]; other site
479433012772	Q-X-W motif; other site
479433012773	Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206
479433012774	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433012775	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433012776	putative sugar binding sites [chemical binding]; other site
479433012777	Q-X-W motif; other site
479433012778	Right handed beta helix region; Region: Beta_helix; pfam13229
479433012779	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433012780	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433012781	putative sugar binding sites [chemical binding]; other site
479433012782	Q-X-W motif; other site
479433012783	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
479433012784	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
479433012785	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
479433012786	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
479433012787	Carbohydrate binding domain X2; Region: CBM_X2; pfam03442
479433012788	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433012789	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433012790	DNA binding site [nucleotide binding]
479433012791	domain linker motif; other site
479433012792	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
479433012793	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
479433012794	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
479433012795	DNA binding residues [nucleotide binding]
479433012796	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
479433012797	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433012798	alpha-galactosidase; Region: PLN02808; cl17638
479433012799	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433012800	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433012801	putative sugar binding sites [chemical binding]; other site
479433012802	Q-X-W motif; other site
479433012803	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
479433012804	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
479433012805	Interdomain contacts; other site
479433012806	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
479433012807	Interdomain contacts; other site
479433012808	Cellulose binding domain; Region: CBM_2; pfam00553
479433012809	Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206
479433012810	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433012811	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433012812	putative sugar binding sites [chemical binding]; other site
479433012813	Q-X-W motif; other site
479433012814	Probable beta-xylosidase; Provisional; Region: PLN03080
479433012815	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
479433012816	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
479433012817	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433012818	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433012819	putative sugar binding sites [chemical binding]; other site
479433012820	Q-X-W motif; other site
479433012821	Glycosyl hydrolase family 62; Region: Glyco_hydro_62; pfam03664
479433012822	active site
479433012823	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
479433012824	NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152
479433012825	NAD(P) binding site [chemical binding]; other site
479433012826	catalytic residues [active]
479433012827	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
479433012828	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
479433012829	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
479433012830	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433012831	TAP-like protein; Region: Abhydrolase_4; pfam08386
479433012832	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
479433012833	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
479433012834	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
479433012835	tetramer interface [polypeptide binding]; other site
479433012836	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
479433012837	active site
479433012838	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
479433012839	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
479433012840	active site
479433012841	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
479433012842	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
479433012843	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
479433012844	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
479433012845	Bacterial transcriptional regulator; Region: IclR; pfam01614
479433012846	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
479433012847	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
479433012848	Bacterial transcriptional regulator; Region: IclR; pfam01614
479433012849	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
479433012850	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
479433012851	FMN-binding pocket [chemical binding]; other site
479433012852	flavin binding motif; other site
479433012853	phosphate binding motif [ion binding]; other site
479433012854	beta-alpha-beta structure motif; other site
479433012855	NAD binding pocket [chemical binding]; other site
479433012856	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
479433012857	catalytic loop [active]
479433012858	iron binding site [ion binding]; other site
479433012859	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
479433012860	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
479433012861	iron-sulfur cluster [ion binding]; other site
479433012862	[2Fe-2S] cluster binding site [ion binding]; other site
479433012863	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
479433012864	hydrophobic ligand binding site; other site
479433012865	Transcriptional regulator [Transcription]; Region: IclR; COG1414
479433012866	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
479433012867	Bacterial transcriptional regulator; Region: IclR; pfam01614
479433012868	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433012869	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433012870	PaaX-like protein; Region: PaaX; pfam07848
479433012871	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
479433012872	short chain dehydrogenase; Provisional; Region: PRK07814
479433012873	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433012874	NAD(P) binding site [chemical binding]; other site
479433012875	active site
479433012876	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
479433012877	active site
479433012878	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
479433012879	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433012880	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
479433012881	acyl-activating enzyme (AAE) consensus motif; other site
479433012882	acyl-activating enzyme (AAE) consensus motif; other site
479433012883	putative AMP binding site [chemical binding]; other site
479433012884	putative active site [active]
479433012885	putative CoA binding site [chemical binding]; other site
479433012886	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
479433012887	putative active site [active]
479433012888	putative catalytic site [active]
479433012889	Glycosyl hydrolase family 43; Region: GH43_6; cd08985
479433012890	active site
479433012891	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433012892	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433012893	putative sugar binding sites [chemical binding]; other site
479433012894	Q-X-W motif; other site
479433012895	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
479433012896	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433012897	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433012898	putative sugar binding sites [chemical binding]; other site
479433012899	Q-X-W motif; other site
479433012900	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
479433012901	Ricin-type beta-trefoil; Region: RICIN; smart00458
479433012902	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433012903	putative sugar binding sites [chemical binding]; other site
479433012904	Q-X-W motif; other site
479433012905	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
479433012906	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433012907	NADH(P)-binding; Region: NAD_binding_10; pfam13460
479433012908	NAD(P) binding site [chemical binding]; other site
479433012909	active site
479433012910	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
479433012911	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
479433012912	active site
479433012913	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433012914	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433012915	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
479433012916	putative substrate binding pocket [chemical binding]; other site
479433012917	putative dimerization interface [polypeptide binding]; other site
479433012918	Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057
479433012919	Ricin-type beta-trefoil; Region: RICIN; smart00458
479433012920	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433012921	putative sugar binding sites [chemical binding]; other site
479433012922	Q-X-W motif; other site
479433012923	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
479433012924	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433012925	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433012926	putative sugar binding sites [chemical binding]; other site
479433012927	Q-X-W motif; other site
479433012928	alpha-galactosidase; Region: PLN02808; cl17638
479433012929	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433012930	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433012931	putative sugar binding sites [chemical binding]; other site
479433012932	Q-X-W motif; other site
479433012933	hypothetical protein; Provisional; Region: PRK06215
479433012934	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
479433012935	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
479433012936	Ligand Binding Site [chemical binding]; other site
479433012937	Protein of unknown function DUF111; Region: DUF111; pfam01969
479433012938	AIR carboxylase; Region: AIRC; smart01001
479433012939	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
479433012940	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
479433012941	Amidohydrolase; Region: Amidohydro_2; pfam04909
479433012942	active site
479433012943	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
479433012944	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
479433012945	Transcriptional regulators [Transcription]; Region: FadR; COG2186
479433012946	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433012947	DNA-binding site [nucleotide binding]; DNA binding site
479433012948	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
479433012949	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
479433012950	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
479433012951	metal binding site [ion binding]; metal-binding site
479433012952	substrate binding pocket [chemical binding]; other site
479433012953	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
479433012954	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
479433012955	ligand binding site [chemical binding]; other site
479433012956	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
479433012957	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
479433012958	Walker A/P-loop; other site
479433012959	ATP binding site [chemical binding]; other site
479433012960	Q-loop/lid; other site
479433012961	ABC transporter signature motif; other site
479433012962	Walker B; other site
479433012963	D-loop; other site
479433012964	H-loop/switch region; other site
479433012965	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
479433012966	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
479433012967	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
479433012968	TM-ABC transporter signature motif; other site
479433012969	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433012970	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433012971	DNA binding site [nucleotide binding]
479433012972	domain linker motif; other site
479433012973	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433012974	dimerization interface [polypeptide binding]; other site
479433012975	ligand binding site [chemical binding]; other site
479433012976	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
479433012977	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433012978	putative sugar binding sites [chemical binding]; other site
479433012979	Q-X-W motif; other site
479433012980	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433012981	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433012982	putative sugar binding sites [chemical binding]; other site
479433012983	Q-X-W motif; other site
479433012984	Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206
479433012985	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433012986	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433012987	putative sugar binding sites [chemical binding]; other site
479433012988	Q-X-W motif; other site
479433012989	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
479433012990	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433012991	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433012992	putative sugar binding sites [chemical binding]; other site
479433012993	Q-X-W motif; other site
479433012994	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433012995	DNA-binding site [nucleotide binding]; DNA binding site
479433012996	Transcriptional regulators [Transcription]; Region: FadR; COG2186
479433012997	Right handed beta helix region; Region: Beta_helix; pfam13229
479433012998	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433012999	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433013000	putative sugar binding sites [chemical binding]; other site
479433013001	Q-X-W motif; other site
479433013002	Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206
479433013003	Ricin-type beta-trefoil; Region: RICIN; smart00458
479433013004	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433013005	putative sugar binding sites [chemical binding]; other site
479433013006	Q-X-W motif; other site
479433013007	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
479433013008	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
479433013009	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433013010	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433013011	putative sugar binding sites [chemical binding]; other site
479433013012	Q-X-W motif; other site
479433013013	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433013014	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433013015	DNA binding site [nucleotide binding]
479433013016	domain linker motif; other site
479433013017	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
479433013018	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433013019	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433013020	DNA binding site [nucleotide binding]
479433013021	domain linker motif; other site
479433013022	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433013023	dimerization interface [polypeptide binding]; other site
479433013024	ligand binding site [chemical binding]; other site
479433013025	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
479433013026	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
479433013027	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
479433013028	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433013029	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433013030	dimer interface [polypeptide binding]; other site
479433013031	ABC-ATPase subunit interface; other site
479433013032	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
479433013033	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433013034	dimer interface [polypeptide binding]; other site
479433013035	conserved gate region; other site
479433013036	ABC-ATPase subunit interface; other site
479433013037	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433013038	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
479433013039	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
479433013040	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
479433013041	PKC phosphorylation site [posttranslational modification]; other site
479433013042	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
479433013043	Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457
479433013044	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433013045	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433013046	putative sugar binding sites [chemical binding]; other site
479433013047	Q-X-W motif; other site
479433013048	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433013049	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433013050	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433013051	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433013052	active site
479433013053	catalytic tetrad [active]
479433013054	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
479433013055	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
479433013056	Predicted membrane protein [Function unknown]; Region: COG2259
479433013057	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
479433013058	Carbohydrate binding domain X2; Region: CBM_X2; pfam03442
479433013059	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
479433013060	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
479433013061	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433013062	sugar binding site [chemical binding]; other site
479433013063	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433013064	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433013065	active site
479433013066	catalytic tetrad [active]
479433013067	2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935
479433013068	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433013069	NAD(P) binding site [chemical binding]; other site
479433013070	active site
479433013071	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
479433013072	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
479433013073	NAD(P) binding site [chemical binding]; other site
479433013074	Domain of unknown function (DUF718); Region: DUF718; pfam05336
479433013075	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433013076	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433013077	dimer interface [polypeptide binding]; other site
479433013078	conserved gate region; other site
479433013079	putative PBP binding loops; other site
479433013080	ABC-ATPase subunit interface; other site
479433013081	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433013082	dimer interface [polypeptide binding]; other site
479433013083	conserved gate region; other site
479433013084	putative PBP binding loops; other site
479433013085	ABC-ATPase subunit interface; other site
479433013086	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433013087	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433013088	Transcriptional regulators [Transcription]; Region: FadR; COG2186
479433013089	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433013090	DNA-binding site [nucleotide binding]; DNA binding site
479433013091	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
479433013092	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
479433013093	Cellulose binding domain; Region: CBM_2; pfam00553
479433013094	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
479433013095	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
479433013096	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433013097	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433013098	putative sugar binding sites [chemical binding]; other site
479433013099	Q-X-W motif; other site
479433013100	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433013101	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433013102	putative sugar binding sites [chemical binding]; other site
479433013103	Q-X-W motif; other site
479433013104	Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305
479433013105	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
479433013106	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
479433013107	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
479433013108	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
479433013109	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
479433013110	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
479433013111	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
479433013112	Cellulose binding domain; Region: CBM_2; pfam00553
479433013113	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
479433013114	UbiA prenyltransferase family; Region: UbiA; pfam01040
479433013115	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
479433013116	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433013117	Cytochrome P450; Region: p450; cl12078
479433013118	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
479433013119	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
479433013120	[2Fe-2S] cluster binding site [ion binding]; other site
479433013121	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
479433013122	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
479433013123	substrate binding pocket [chemical binding]; other site
479433013124	chain length determination region; other site
479433013125	substrate-Mg2+ binding site; other site
479433013126	catalytic residues [active]
479433013127	aspartate-rich region 1; other site
479433013128	active site lid residues [active]
479433013129	aspartate-rich region 2; other site
479433013130	Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206
479433013131	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257
479433013132	PKC phosphorylation site [posttranslational modification]; other site
479433013133	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
479433013134	PKC phosphorylation site [posttranslational modification]; other site
479433013135	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
479433013136	IHF dimer interface [polypeptide binding]; other site
479433013137	IHF - DNA interface [nucleotide binding]; other site
479433013138	Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752
479433013139	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433013140	sugar binding site [chemical binding]; other site
479433013141	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433013142	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
479433013143	substrate binding site [chemical binding]; other site
479433013144	catalytic residues [active]
479433013145	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433013146	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433013147	DNA binding site [nucleotide binding]
479433013148	domain linker motif; other site
479433013149	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433013150	ligand binding site [chemical binding]; other site
479433013151	dimerization interface [polypeptide binding]; other site
479433013152	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433013153	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433013154	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
479433013155	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433013156	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433013157	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433013158	dimer interface [polypeptide binding]; other site
479433013159	conserved gate region; other site
479433013160	putative PBP binding loops; other site
479433013161	ABC-ATPase subunit interface; other site
479433013162	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433013163	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433013164	dimer interface [polypeptide binding]; other site
479433013165	conserved gate region; other site
479433013166	putative PBP binding loops; other site
479433013167	ABC-ATPase subunit interface; other site
479433013168	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
479433013169	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
479433013170	FAD binding domain; Region: FAD_binding_4; pfam01565
479433013171	Berberine and berberine like; Region: BBE; pfam08031
479433013172	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
479433013173	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
479433013174	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433013175	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433013176	DNA binding site [nucleotide binding]
479433013177	domain linker motif; other site
479433013178	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433013179	dimerization interface [polypeptide binding]; other site
479433013180	ligand binding site [chemical binding]; other site
479433013181	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433013182	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433013183	dimer interface [polypeptide binding]; other site
479433013184	conserved gate region; other site
479433013185	ABC-ATPase subunit interface; other site
479433013186	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433013187	ABC-ATPase subunit interface; other site
479433013188	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433013189	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
479433013190	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
479433013191	Transcriptional regulator [Transcription]; Region: IclR; COG1414
479433013192	Bacterial transcriptional regulator; Region: IclR; pfam01614
479433013193	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433013194	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433013195	putative sugar binding sites [chemical binding]; other site
479433013196	Q-X-W motif; other site
479433013197	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
479433013198	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
479433013199	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
479433013200	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433013201	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433013202	DNA binding site [nucleotide binding]
479433013203	domain linker motif; other site
479433013204	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
479433013205	ligand binding site [chemical binding]; other site
479433013206	dimerization interface (open form) [polypeptide binding]; other site
479433013207	dimerization interface (closed form) [polypeptide binding]; other site
479433013208	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
479433013209	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433013210	putative NAD(P) binding site [chemical binding]; other site
479433013211	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433013212	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433013213	sequence-specific DNA binding site [nucleotide binding]; other site
479433013214	salt bridge; other site
479433013215	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433013216	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
479433013217	Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081
479433013218	Ca binding site [ion binding]; other site
479433013219	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
479433013220	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433013221	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433013222	Ricin-type beta-trefoil; Region: RICIN; smart00458
479433013223	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433013224	putative sugar binding sites [chemical binding]; other site
479433013225	Q-X-W motif; other site
479433013226	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
479433013227	alpha-galactosidase; Region: PLN02808; cl17638
479433013228	NPCBM/NEW2 domain; Region: NPCBM; pfam08305
479433013229	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433013230	sugar binding site [chemical binding]; other site
479433013231	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
479433013232	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
479433013233	TM-ABC transporter signature motif; other site
479433013234	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
479433013235	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
479433013236	Walker A/P-loop; other site
479433013237	ATP binding site [chemical binding]; other site
479433013238	Q-loop/lid; other site
479433013239	ABC transporter signature motif; other site
479433013240	Walker B; other site
479433013241	D-loop; other site
479433013242	H-loop/switch region; other site
479433013243	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
479433013244	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
479433013245	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
479433013246	classical (c) SDRs; Region: SDR_c; cd05233
479433013247	NAD(P) binding site [chemical binding]; other site
479433013248	active site
479433013249	Transcriptional regulators [Transcription]; Region: FadR; COG2186
479433013250	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433013251	DNA-binding site [nucleotide binding]; DNA binding site
479433013252	FCD domain; Region: FCD; pfam07729
479433013253	galactonate dehydratase; Provisional; Region: PRK14017
479433013254	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
479433013255	putative active site pocket [active]
479433013256	putative metal binding site [ion binding]; other site
479433013257	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
479433013258	active site
479433013259	intersubunit interface [polypeptide binding]; other site
479433013260	catalytic residue [active]
479433013261	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
479433013262	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
479433013263	substrate binding site [chemical binding]; other site
479433013264	ATP binding site [chemical binding]; other site
479433013265	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433013266	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
479433013267	putative NAD(P) binding site [chemical binding]; other site
479433013268	MarR family; Region: MarR_2; pfam12802
479433013269	enolase; Provisional; Region: eno; PRK00077
479433013270	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
479433013271	dimer interface [polypeptide binding]; other site
479433013272	metal binding site [ion binding]; metal-binding site
479433013273	substrate binding pocket [chemical binding]; other site
479433013274	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
479433013275	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
479433013276	[4Fe-4S] binding site [ion binding]; other site
479433013277	molybdopterin cofactor binding site; other site
479433013278	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
479433013279	molybdopterin cofactor binding site; other site
479433013280	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
479433013281	Flavodoxin; Region: Flavodoxin_1; pfam00258
479433013282	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
479433013283	FAD binding pocket [chemical binding]; other site
479433013284	FAD binding motif [chemical binding]; other site
479433013285	catalytic residues [active]
479433013286	NAD binding pocket [chemical binding]; other site
479433013287	phosphate binding motif [ion binding]; other site
479433013288	beta-alpha-beta structure motif; other site
479433013289	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
479433013290	active site
479433013291	catalytic residues [active]
479433013292	metal binding site [ion binding]; metal-binding site
479433013293	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
479433013294	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
479433013295	N-terminal catalytic domain of mainly uncharacterized eukaryotic proteins similar to alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like_1; cd10791
479433013296	putative active site [active]
479433013297	catalytic site [active]
479433013298	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433013299	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433013300	dimer interface [polypeptide binding]; other site
479433013301	conserved gate region; other site
479433013302	putative PBP binding loops; other site
479433013303	ABC-ATPase subunit interface; other site
479433013304	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433013305	dimer interface [polypeptide binding]; other site
479433013306	conserved gate region; other site
479433013307	putative PBP binding loops; other site
479433013308	ABC-ATPase subunit interface; other site
479433013309	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433013310	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
479433013311	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433013312	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433013313	DNA binding site [nucleotide binding]
479433013314	domain linker motif; other site
479433013315	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433013316	dimerization interface [polypeptide binding]; other site
479433013317	ligand binding site [chemical binding]; other site
479433013318	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
479433013319	Predicted acyl esterases [General function prediction only]; Region: COG2936
479433013320	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
479433013321	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
479433013322	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433013323	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
479433013324	dimerization interface [polypeptide binding]; other site
479433013325	substrate binding pocket [chemical binding]; other site
479433013326	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433013327	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
479433013328	NAD(P) binding site [chemical binding]; other site
479433013329	active site
479433013330	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
479433013331	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433013332	sugar binding site [chemical binding]; other site
479433013333	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
479433013334	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433013335	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433013336	DNA binding residues [nucleotide binding]
479433013337	dimerization interface [polypeptide binding]; other site
479433013338	short chain dehydrogenase; Provisional; Region: PRK07454
479433013339	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433013340	NAD(P) binding site [chemical binding]; other site
479433013341	active site
479433013342	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
479433013343	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
479433013344	DNA binding site [nucleotide binding]
479433013345	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433013346	NB-ARC domain; Region: NB-ARC; pfam00931
479433013347	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433013348	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433013349	TPR motif; other site
479433013350	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433013351	binding surface
479433013352	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
479433013353	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
479433013354	Zn binding site [ion binding]; other site
479433013355	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
479433013356	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
479433013357	metal binding site [ion binding]; metal-binding site
479433013358	substrate binding pocket [chemical binding]; other site
479433013359	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
479433013360	putative metal binding site [ion binding]; other site
479433013361	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
479433013362	putative metal binding site [ion binding]; other site
479433013363	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
479433013364	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433013365	sugar binding site [chemical binding]; other site
479433013366	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
479433013367	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
479433013368	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
479433013369	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
479433013370	Nitronate monooxygenase; Region: NMO; pfam03060
479433013371	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
479433013372	FMN binding site [chemical binding]; other site
479433013373	substrate binding site [chemical binding]; other site
479433013374	putative catalytic residue [active]
479433013375	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
479433013376	active site
479433013377	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
479433013378	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433013379	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433013380	DNA binding residues [nucleotide binding]
479433013381	dimerization interface [polypeptide binding]; other site
479433013382	CHAP domain; Region: CHAP; cl17642
479433013383	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
479433013384	DNA binding site [nucleotide binding]
479433013385	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433013386	AAA ATPase domain; Region: AAA_16; pfam13191
479433013387	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433013388	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433013389	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433013390	binding surface
479433013391	TPR motif; other site
479433013392	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433013393	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
479433013394	Leucine carboxyl methyltransferase; Region: LCM; cl01306
479433013395	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433013396	non-specific DNA binding site [nucleotide binding]; other site
479433013397	salt bridge; other site
479433013398	sequence-specific DNA binding site [nucleotide binding]; other site
479433013399	Subtilisin inhibitor-like; Region: SSI; cl11594
479433013400	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
479433013401	Ligand Binding Site [chemical binding]; other site
479433013402	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
479433013403	Ligand Binding Site [chemical binding]; other site
479433013404	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
479433013405	Mechanosensitive ion channel; Region: MS_channel; pfam00924
479433013406	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433013407	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433013408	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
479433013409	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
479433013410	putative catalytic residues [active]
479433013411	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
479433013412	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433013413	S-adenosylmethionine binding site [chemical binding]; other site
479433013414	Cupin domain; Region: Cupin_2; pfam07883
479433013415	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
479433013416	MbtH-like protein; Region: MbtH; cl01279
479433013417	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433013418	Condensation domain; Region: Condensation; pfam00668
479433013419	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
479433013420	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
479433013421	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
479433013422	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
479433013423	acyl-activating enzyme (AAE) consensus motif; other site
479433013424	AMP binding site [chemical binding]; other site
479433013425	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433013426	Condensation domain; Region: Condensation; pfam00668
479433013427	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
479433013428	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
479433013429	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
479433013430	acyl-activating enzyme (AAE) consensus motif; other site
479433013431	AMP binding site [chemical binding]; other site
479433013432	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433013433	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
479433013434	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
479433013435	E3 interaction surface; other site
479433013436	lipoyl attachment site [posttranslational modification]; other site
479433013437	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
479433013438	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
479433013439	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
479433013440	PYR/PP interface [polypeptide binding]; other site
479433013441	dimer interface [polypeptide binding]; other site
479433013442	TPP binding site [chemical binding]; other site
479433013443	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
479433013444	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
479433013445	tetramer interface [polypeptide binding]; other site
479433013446	TPP-binding site [chemical binding]; other site
479433013447	heterodimer interface [polypeptide binding]; other site
479433013448	phosphorylation loop region [posttranslational modification]
479433013449	Condensation domain; Region: Condensation; pfam00668
479433013450	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
479433013451	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433013452	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
479433013453	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433013454	acyl-activating enzyme (AAE) consensus motif; other site
479433013455	AMP binding site [chemical binding]; other site
479433013456	active site
479433013457	CoA binding site [chemical binding]; other site
479433013458	peptide synthase; Provisional; Region: PRK12316
479433013459	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
479433013460	Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162
479433013461	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
479433013462	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
479433013463	putative ADP-binding pocket [chemical binding]; other site
479433013464	Condensation domain; Region: Condensation; pfam00668
479433013465	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
479433013466	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
479433013467	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
479433013468	acyl-activating enzyme (AAE) consensus motif; other site
479433013469	AMP binding site [chemical binding]; other site
479433013470	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433013471	Thioesterase domain; Region: Thioesterase; pfam00975
479433013472	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433013473	putative substrate translocation pore; other site
479433013474	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
479433013475	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
479433013476	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
479433013477	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
479433013478	short chain dehydrogenase; Provisional; Region: PRK07041
479433013479	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433013480	NAD(P) binding site [chemical binding]; other site
479433013481	active site
479433013482	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433013483	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433013484	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
479433013485	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433013486	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433013487	WHG domain; Region: WHG; pfam13305
479433013488	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
479433013489	Predicted membrane protein [Function unknown]; Region: COG3463
479433013490	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
479433013491	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433013492	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433013493	dimer interface [polypeptide binding]; other site
479433013494	phosphorylation site [posttranslational modification]
479433013495	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433013496	ATP binding site [chemical binding]; other site
479433013497	Mg2+ binding site [ion binding]; other site
479433013498	G-X-G motif; other site
479433013499	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433013500	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433013501	active site
479433013502	phosphorylation site [posttranslational modification]
479433013503	intermolecular recognition site; other site
479433013504	dimerization interface [polypeptide binding]; other site
479433013505	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433013506	DNA binding site [nucleotide binding]
479433013507	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433013508	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433013509	putative sugar binding sites [chemical binding]; other site
479433013510	Q-X-W motif; other site
479433013511	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433013512	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433013513	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
479433013514	putative substrate binding pocket [chemical binding]; other site
479433013515	putative dimerization interface [polypeptide binding]; other site
479433013516	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
479433013517	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433013518	NAD(P) binding site [chemical binding]; other site
479433013519	active site
479433013520	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
479433013521	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
479433013522	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433013523	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433013524	active site
479433013525	ATP binding site [chemical binding]; other site
479433013526	substrate binding site [chemical binding]; other site
479433013527	activation loop (A-loop); other site
479433013528	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433013529	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433013530	active site
479433013531	catalytic tetrad [active]
479433013532	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433013533	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433013534	dimer interface [polypeptide binding]; other site
479433013535	conserved gate region; other site
479433013536	putative PBP binding loops; other site
479433013537	ABC-ATPase subunit interface; other site
479433013538	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433013539	dimer interface [polypeptide binding]; other site
479433013540	conserved gate region; other site
479433013541	ABC-ATPase subunit interface; other site
479433013542	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433013543	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433013544	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
479433013545	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
479433013546	NAD(P) binding site [chemical binding]; other site
479433013547	catalytic residues [active]
479433013548	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
479433013549	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
479433013550	putative switch regulator; other site
479433013551	non-specific DNA interactions [nucleotide binding]; other site
479433013552	DNA binding site [nucleotide binding]
479433013553	sequence specific DNA binding site [nucleotide binding]; other site
479433013554	putative cAMP binding site [chemical binding]; other site
479433013555	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433013556	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
479433013557	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
479433013558	active site
479433013559	catalytic triad [active]
479433013560	calcium binding site [ion binding]; other site
479433013561	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
479433013562	Phosphoesterase family; Region: Phosphoesterase; pfam04185
479433013563	Domain of unknown function (DUF756); Region: DUF756; pfam05506
479433013564	Domain of unknown function (DUF756); Region: DUF756; pfam05506
479433013565	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
479433013566	B3/4 domain; Region: B3_4; pfam03483
479433013567	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433013568	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
479433013569	Walker A/P-loop; other site
479433013570	ATP binding site [chemical binding]; other site
479433013571	Q-loop/lid; other site
479433013572	ABC transporter signature motif; other site
479433013573	Walker B; other site
479433013574	D-loop; other site
479433013575	H-loop/switch region; other site
479433013576	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
479433013577	Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589
479433013578	putative active site [active]
479433013579	catalytic site [active]
479433013580	putative metal binding site [ion binding]; other site
479433013581	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433013582	dimerization interface [polypeptide binding]; other site
479433013583	putative DNA binding site [nucleotide binding]; other site
479433013584	putative Zn2+ binding site [ion binding]; other site
479433013585	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
479433013586	putative hydrophobic ligand binding site [chemical binding]; other site
479433013587	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
479433013588	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433013589	Domain of unknown function (DUF427); Region: DUF427; pfam04248
479433013590	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433013591	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433013592	active site
479433013593	catalytic tetrad [active]
479433013594	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433013595	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433013596	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
479433013597	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
479433013598	DNA binding residues [nucleotide binding]
479433013599	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
479433013600	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
479433013601	glycerol kinase; Provisional; Region: glpK; PRK00047
479433013602	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
479433013603	nucleotide binding site [chemical binding]; other site
479433013604	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
479433013605	amphipathic channel; other site
479433013606	Asn-Pro-Ala signature motifs; other site
479433013607	Transcriptional regulator [Transcription]; Region: IclR; COG1414
479433013608	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
479433013609	Bacterial transcriptional regulator; Region: IclR; pfam01614
479433013610	glycerol kinase; Provisional; Region: glpK; PRK00047
479433013611	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
479433013612	nucleotide binding site [chemical binding]; other site
479433013613	Isochorismatase family; Region: Isochorismatase; pfam00857
479433013614	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
479433013615	catalytic triad [active]
479433013616	conserved cis-peptide bond; other site
479433013617	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
479433013618	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
479433013619	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
479433013620	putative transporter; Provisional; Region: PRK10504
479433013621	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433013622	putative substrate translocation pore; other site
479433013623	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433013624	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433013625	WHG domain; Region: WHG; pfam13305
479433013626	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433013627	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
479433013628	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433013629	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433013630	DNA binding residues [nucleotide binding]
479433013631	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433013632	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433013633	putative substrate translocation pore; other site
479433013634	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433013635	AAA ATPase domain; Region: AAA_16; pfam13191
479433013636	AAA ATPase domain; Region: AAA_16; pfam13191
479433013637	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433013638	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433013639	DNA binding residues [nucleotide binding]
479433013640	dimerization interface [polypeptide binding]; other site
479433013641	AAA ATPase domain; Region: AAA_16; pfam13191
479433013642	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433013643	DNA binding residues [nucleotide binding]
479433013644	AAA ATPase domain; Region: AAA_16; pfam13191
479433013645	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433013646	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433013647	DNA binding residues [nucleotide binding]
479433013648	dimerization interface [polypeptide binding]; other site
479433013649	short chain dehydrogenase; Provisional; Region: PRK06180
479433013650	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
479433013651	NADP binding site [chemical binding]; other site
479433013652	active site
479433013653	steroid binding site; other site
479433013654	short chain dehydrogenase; Provisional; Region: PRK06180
479433013655	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
479433013656	NADP binding site [chemical binding]; other site
479433013657	active site
479433013658	steroid binding site; other site
479433013659	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433013660	TIGR01777 family protein; Region: yfcH
479433013661	NAD(P) binding site [chemical binding]; other site
479433013662	active site
479433013663	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
479433013664	active site
479433013665	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
479433013666	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
479433013667	active site
479433013668	substrate binding site [chemical binding]; other site
479433013669	ATP binding site [chemical binding]; other site
479433013670	Phosphotransferase enzyme family; Region: APH; pfam01636
479433013671	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433013672	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
479433013673	NAD(P) binding site [chemical binding]; other site
479433013674	active site
479433013675	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
479433013676	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
479433013677	metal binding site [ion binding]; metal-binding site
479433013678	substrate binding pocket [chemical binding]; other site
479433013679	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
479433013680	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
479433013681	putative active site [active]
479433013682	catalytic residue [active]
479433013683	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
479433013684	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
479433013685	motif II; other site
479433013686	PAS fold; Region: PAS_4; pfam08448
479433013687	PAS fold; Region: PAS_4; pfam08448
479433013688	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
479433013689	putative active site [active]
479433013690	heme pocket [chemical binding]; other site
479433013691	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
479433013692	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
479433013693	metal binding site [ion binding]; metal-binding site
479433013694	active site
479433013695	I-site; other site
479433013696	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
479433013697	Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206
479433013698	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
479433013699	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
479433013700	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
479433013701	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
479433013702	active site
479433013703	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
479433013704	SnoaL-like domain; Region: SnoaL_2; pfam12680
479433013705	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
479433013706	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
479433013707	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433013708	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433013709	putative sugar binding sites [chemical binding]; other site
479433013710	Q-X-W motif; other site
479433013711	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
479433013712	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433013713	NADH(P)-binding; Region: NAD_binding_10; pfam13460
479433013714	NAD(P) binding site [chemical binding]; other site
479433013715	active site
479433013716	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
479433013717	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
479433013718	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
479433013719	Alginate lyase; Region: Alginate_lyase; pfam05426
479433013720	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433013721	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
479433013722	Walker A/P-loop; other site
479433013723	ATP binding site [chemical binding]; other site
479433013724	Q-loop/lid; other site
479433013725	ABC transporter signature motif; other site
479433013726	Walker B; other site
479433013727	D-loop; other site
479433013728	H-loop/switch region; other site
479433013729	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
479433013730	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
479433013731	ABC-2 type transporter; Region: ABC2_membrane; cl17235
479433013732	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
479433013733	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433013734	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
479433013735	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
479433013736	tetramer interface [polypeptide binding]; other site
479433013737	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433013738	catalytic residue [active]
479433013739	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433013740	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
479433013741	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433013742	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
479433013743	putative NAD(P) binding site [chemical binding]; other site
479433013744	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
479433013745	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
479433013746	conserved cys residue [active]
479433013747	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433013748	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433013749	Domain of unknown function (DUF4037); Region: DUF4037; pfam13228
479433013750	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
479433013751	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
479433013752	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433013753	Walker A/P-loop; other site
479433013754	ATP binding site [chemical binding]; other site
479433013755	Q-loop/lid; other site
479433013756	ABC transporter signature motif; other site
479433013757	Walker B; other site
479433013758	D-loop; other site
479433013759	H-loop/switch region; other site
479433013760	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
479433013761	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
479433013762	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433013763	Q-loop/lid; other site
479433013764	ABC transporter signature motif; other site
479433013765	Walker B; other site
479433013766	D-loop; other site
479433013767	H-loop/switch region; other site
479433013768	Nitrate and nitrite sensing; Region: NIT; pfam08376
479433013769	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433013770	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433013771	ATP binding site [chemical binding]; other site
479433013772	Mg2+ binding site [ion binding]; other site
479433013773	G-X-G motif; other site
479433013774	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
479433013775	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
479433013776	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
479433013777	G1 box; other site
479433013778	GTP/Mg2+ binding site [chemical binding]; other site
479433013779	G2 box; other site
479433013780	Switch I region; other site
479433013781	G3 box; other site
479433013782	Switch II region; other site
479433013783	G4 box; other site
479433013784	G5 box; other site
479433013785	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
479433013786	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
479433013787	hypothetical protein; Provisional; Region: PRK07236
479433013788	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
479433013789	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
479433013790	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
479433013791	dimer interface [polypeptide binding]; other site
479433013792	active site
479433013793	CoA binding pocket [chemical binding]; other site
479433013794	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
479433013795	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
479433013796	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
479433013797	putative homodimer interface [polypeptide binding]; other site
479433013798	putative homotetramer interface [polypeptide binding]; other site
479433013799	putative allosteric switch controlling residues; other site
479433013800	putative metal binding site [ion binding]; other site
479433013801	putative homodimer-homodimer interface [polypeptide binding]; other site
479433013802	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
479433013803	active site
479433013804	catalytic residues [active]
479433013805	metal binding site [ion binding]; metal-binding site
479433013806	Transglycosylase; Region: Transgly; pfam00912
479433013807	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
479433013808	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
479433013809	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
479433013810	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
479433013811	CoenzymeA binding site [chemical binding]; other site
479433013812	subunit interaction site [polypeptide binding]; other site
479433013813	PHB binding site; other site
479433013814	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
479433013815	CoenzymeA binding site [chemical binding]; other site
479433013816	subunit interaction site [polypeptide binding]; other site
479433013817	PHB binding site; other site
479433013818	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433013819	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433013820	Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719
479433013821	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
479433013822	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
479433013823	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433013824	NAD(P) binding site [chemical binding]; other site
479433013825	active site
479433013826	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
479433013827	GAF domain; Region: GAF; pfam01590
479433013828	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
479433013829	Histidine kinase; Region: HisKA_3; pfam07730
479433013830	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433013831	ATP binding site [chemical binding]; other site
479433013832	Mg2+ binding site [ion binding]; other site
479433013833	G-X-G motif; other site
479433013834	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433013835	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433013836	active site
479433013837	phosphorylation site [posttranslational modification]
479433013838	intermolecular recognition site; other site
479433013839	dimerization interface [polypeptide binding]; other site
479433013840	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433013841	DNA binding residues [nucleotide binding]
479433013842	dimerization interface [polypeptide binding]; other site
479433013843	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
479433013844	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
479433013845	catalytic residues [active]
479433013846	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
479433013847	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433013848	Coenzyme A binding pocket [chemical binding]; other site
479433013849	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
479433013850	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433013851	methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364
479433013852	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433013853	S-adenosylmethionine binding site [chemical binding]; other site
479433013854	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
479433013855	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
479433013856	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
479433013857	active site
479433013858	oxyanion hole [active]
479433013859	NAD synthetase; Reviewed; Region: nadE; PRK02628
479433013860	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
479433013861	multimer interface [polypeptide binding]; other site
479433013862	active site
479433013863	catalytic triad [active]
479433013864	protein interface 1 [polypeptide binding]; other site
479433013865	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
479433013866	homodimer interface [polypeptide binding]; other site
479433013867	NAD binding pocket [chemical binding]; other site
479433013868	ATP binding pocket [chemical binding]; other site
479433013869	Mg binding site [ion binding]; other site
479433013870	active-site loop [active]
479433013871	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
479433013872	Ligand Binding Site [chemical binding]; other site
479433013873	Predicted transcriptional regulators [Transcription]; Region: COG1733
479433013874	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433013875	dimerization interface [polypeptide binding]; other site
479433013876	putative DNA binding site [nucleotide binding]; other site
479433013877	putative Zn2+ binding site [ion binding]; other site
479433013878	SnoaL-like domain; Region: SnoaL_2; pfam12680
479433013879	SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830
479433013880	active site
479433013881	catalytic triad [active]
479433013882	oxyanion hole [active]
479433013883	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
479433013884	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
479433013885	PKC phosphorylation site [posttranslational modification]; other site
479433013886	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
479433013887	Probable beta-xylosidase; Provisional; Region: PLN03080
479433013888	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
479433013889	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
479433013890	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
479433013891	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
479433013892	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
479433013893	PKC phosphorylation site [posttranslational modification]; other site
479433013894	MarR family; Region: MarR_2; pfam12802
479433013895	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433013896	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
479433013897	nucleotide binding site [chemical binding]; other site
479433013898	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
479433013899	Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206
479433013900	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433013901	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433013902	putative sugar binding sites [chemical binding]; other site
479433013903	Q-X-W motif; other site
479433013904	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433013905	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433013906	putative sugar binding sites [chemical binding]; other site
479433013907	Q-X-W motif; other site
479433013908	glycoside hydrolase family 64: beta-1,3-glucanase B (GluB)-like; Region: GH64-GluB-like; cd09220
479433013909	substrate binding pocket [chemical binding]; other site
479433013910	catalytic residues [active]
479433013911	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
479433013912	metal binding site [ion binding]; metal-binding site
479433013913	ligand binding site [chemical binding]; other site
479433013914	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663
479433013915	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
479433013916	Fe-S cluster binding site [ion binding]; other site
479433013917	DNA binding site [nucleotide binding]
479433013918	active site
479433013919	short chain dehydrogenase; Provisional; Region: PRK07677
479433013920	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433013921	NAD(P) binding site [chemical binding]; other site
479433013922	active site
479433013923	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
479433013924	enoyl-CoA hydratase; Provisional; Region: PRK06127
479433013925	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
479433013926	substrate binding site [chemical binding]; other site
479433013927	oxyanion hole (OAH) forming residues; other site
479433013928	trimer interface [polypeptide binding]; other site
479433013929	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
479433013930	TPP-binding site [chemical binding]; other site
479433013931	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
479433013932	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
479433013933	Small secreted domain (DUF320); Region: DUF320; pfam03777
479433013934	Small secreted domain (DUF320); Region: DUF320; pfam03777
479433013935	Small secreted domain (DUF320); Region: DUF320; pfam03777
479433013936	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
479433013937	active site
479433013938	NIPSNAP; Region: NIPSNAP; pfam07978
479433013939	Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A; Region: PNGaseA; pfam12222
479433013940	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
479433013941	N-acetyltransferase; Region: Acetyltransf_2; pfam00797
479433013942	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
479433013943	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
479433013944	active site
479433013945	PHP Thumb interface [polypeptide binding]; other site
479433013946	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
479433013947	generic binding surface II; other site
479433013948	generic binding surface I; other site
479433013949	DNA Polymerase Y-family; Region: PolY_like; cd03468
479433013950	active site
479433013951	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
479433013952	DNA binding site [nucleotide binding]
479433013953	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433013954	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
479433013955	NAD(P) binding site [chemical binding]; other site
479433013956	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
479433013957	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
479433013958	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
479433013959	putative DNA binding site [nucleotide binding]; other site
479433013960	putative homodimer interface [polypeptide binding]; other site
479433013961	DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298
479433013962	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
479433013963	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
479433013964	active site
479433013965	DNA binding site [nucleotide binding]
479433013966	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
479433013967	DNA binding site [nucleotide binding]
479433013968	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
479433013969	nucleotide binding site [chemical binding]; other site
479433013970	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
479433013971	motif II; other site
479433013972	Protein of unknown function (DUF2690); Region: DUF2690; pfam10901
479433013973	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
479433013974	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
479433013975	active site
479433013976	FMN binding site [chemical binding]; other site
479433013977	substrate binding site [chemical binding]; other site
479433013978	putative catalytic residue [active]
479433013979	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
479433013980	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433013981	NAD(P) binding site [chemical binding]; other site
479433013982	active site
479433013983	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
479433013984	FeS/SAM binding site; other site
479433013985	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
479433013986	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433013987	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
479433013988	Predicted membrane protein [Function unknown]; Region: COG2246
479433013989	GtrA-like protein; Region: GtrA; pfam04138
479433013990	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
479433013991	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
479433013992	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
479433013993	Epoxide hydrolase N terminus; Region: EHN; pfam06441
479433013994	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433013995	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
479433013996	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
479433013997	substrate binding site [chemical binding]; other site
479433013998	oxyanion hole (OAH) forming residues; other site
479433013999	trimer interface [polypeptide binding]; other site
479433014000	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
479433014001	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
479433014002	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
479433014003	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
479433014004	dimer interface [polypeptide binding]; other site
479433014005	active site
479433014006	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433014007	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433014008	active site
479433014009	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
479433014010	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433014011	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433014012	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
479433014013	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
479433014014	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
479433014015	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
479433014016	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
479433014017	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
479433014018	dimerization domain swap beta strand [polypeptide binding]; other site
479433014019	regulatory protein interface [polypeptide binding]; other site
479433014020	active site
479433014021	regulatory phosphorylation site [posttranslational modification]; other site
479433014022	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
479433014023	L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235
479433014024	putative NAD(P) binding site [chemical binding]; other site
479433014025	catalytic Zn binding site [ion binding]; other site
479433014026	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
479433014027	active site
479433014028	phosphorylation site [posttranslational modification]
479433014029	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
479433014030	active site
479433014031	P-loop; other site
479433014032	phosphorylation site [posttranslational modification]
479433014033	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
479433014034	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
479433014035	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
479433014036	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
479433014037	putative substrate binding site [chemical binding]; other site
479433014038	putative ATP binding site [chemical binding]; other site
479433014039	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
479433014040	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
479433014041	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
479433014042	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
479433014043	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
479433014044	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
479433014045	Walker A/P-loop; other site
479433014046	ATP binding site [chemical binding]; other site
479433014047	Q-loop/lid; other site
479433014048	ABC transporter signature motif; other site
479433014049	Walker B; other site
479433014050	D-loop; other site
479433014051	H-loop/switch region; other site
479433014052	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
479433014053	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
479433014054	TM-ABC transporter signature motif; other site
479433014055	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
479433014056	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
479433014057	TM-ABC transporter signature motif; other site
479433014058	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
479433014059	rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637
479433014060	ligand binding site [chemical binding]; other site
479433014061	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
479433014062	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
479433014063	DNA binding site [nucleotide binding]
479433014064	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
479433014065	NB-ARC domain; Region: NB-ARC; pfam00931
479433014066	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
479433014067	peptidase domain interface [polypeptide binding]; other site
479433014068	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
479433014069	active site
479433014070	catalytic triad [active]
479433014071	calcium binding site [ion binding]; other site
479433014072	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433014073	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433014074	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433014075	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433014076	Cytochrome P450; Region: p450; cl12078
479433014077	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433014078	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433014079	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433014080	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433014081	putative substrate translocation pore; other site
479433014082	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
479433014083	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
479433014084	dimerization interface [polypeptide binding]; other site
479433014085	NAD binding site [chemical binding]; other site
479433014086	ligand binding site [chemical binding]; other site
479433014087	catalytic site [active]
479433014088	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
479433014089	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
479433014090	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
479433014091	MarR family; Region: MarR_2; cl17246
479433014092	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
479433014093	anti sigma factor interaction site; other site
479433014094	regulatory phosphorylation site [posttranslational modification]; other site
479433014095	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
479433014096	heat shock protein 90; Provisional; Region: PRK05218
479433014097	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433014098	ATP binding site [chemical binding]; other site
479433014099	Mg2+ binding site [ion binding]; other site
479433014100	G-X-G motif; other site
479433014101	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433014102	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
479433014103	Low molecular weight S layer protein N terminal; Region: LMWSLP_N; pfam12211
479433014104	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
479433014105	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433014106	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
479433014107	Walker A/P-loop; other site
479433014108	ATP binding site [chemical binding]; other site
479433014109	Q-loop/lid; other site
479433014110	ABC transporter signature motif; other site
479433014111	Walker B; other site
479433014112	D-loop; other site
479433014113	H-loop/switch region; other site
479433014114	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
479433014115	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
479433014116	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433014117	Walker A/P-loop; other site
479433014118	ATP binding site [chemical binding]; other site
479433014119	Q-loop/lid; other site
479433014120	ABC transporter signature motif; other site
479433014121	Walker B; other site
479433014122	D-loop; other site
479433014123	H-loop/switch region; other site
479433014124	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
479433014125	ligand binding site [chemical binding]; other site
479433014126	active site
479433014127	UGI interface [polypeptide binding]; other site
479433014128	catalytic site [active]
479433014129	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
479433014130	active site
479433014131	catalytic residues [active]
479433014132	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
479433014133	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433014134	CHAT domain; Region: CHAT; cl17868
479433014135	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
479433014136	enoyl-CoA hydratase; Provisional; Region: PRK07799
479433014137	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
479433014138	substrate binding site [chemical binding]; other site
479433014139	oxyanion hole (OAH) forming residues; other site
479433014140	trimer interface [polypeptide binding]; other site
479433014141	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
479433014142	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
479433014143	Protein of unknown function (DUF664); Region: DUF664; pfam04978
479433014144	DinB superfamily; Region: DinB_2; pfam12867
479433014145	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
479433014146	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433014147	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
479433014148	probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885
479433014149	Small secreted domain (DUF320); Region: DUF320; pfam03777
479433014150	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
479433014151	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
479433014152	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
479433014153	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433014154	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433014155	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
479433014156	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
479433014157	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
479433014158	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
479433014159	putative active site [active]
479433014160	catalytic site [active]
479433014161	putative metal binding site [ion binding]; other site
479433014162	Vacuole effluxer Atg22 like; Region: ATG22; pfam11700
479433014163	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433014164	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
479433014165	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
479433014166	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
479433014167	Ligand binding site; other site
479433014168	Putative Catalytic site; other site
479433014169	DXD motif; other site
479433014170	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
479433014171	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
479433014172	putative active site [active]
479433014173	catalytic triad [active]
479433014174	putative dimer interface [polypeptide binding]; other site
479433014175	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
479433014176	active site
479433014177	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
479433014178	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433014179	putative DNA binding site [nucleotide binding]; other site
479433014180	putative Zn2+ binding site [ion binding]; other site
479433014181	AsnC family; Region: AsnC_trans_reg; pfam01037
479433014182	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
479433014183	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
479433014184	DNA binding residues [nucleotide binding]
479433014185	isovaleryl-CoA dehydrogenase; Provisional; Region: PTZ00461
479433014186	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433014187	active site
479433014188	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
479433014189	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
479433014190	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
479433014191	active site
479433014192	Mitomycin C resistance protein (MRD); Region: MRD; cd07235
479433014193	dimer interface [polypeptide binding]; other site
479433014194	ligand binding site [chemical binding]; other site
479433014195	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433014196	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
479433014197	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433014198	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
479433014199	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433014200	dimer interface [polypeptide binding]; other site
479433014201	conserved gate region; other site
479433014202	putative PBP binding loops; other site
479433014203	ABC-ATPase subunit interface; other site
479433014204	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433014205	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433014206	dimer interface [polypeptide binding]; other site
479433014207	conserved gate region; other site
479433014208	putative PBP binding loops; other site
479433014209	ABC-ATPase subunit interface; other site
479433014210	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
479433014211	beta-galactosidase; Region: BGL; TIGR03356
479433014212	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433014213	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433014214	DNA binding site [nucleotide binding]
479433014215	domain linker motif; other site
479433014216	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
479433014217	putative dimerization interface [polypeptide binding]; other site
479433014218	putative ligand binding site [chemical binding]; other site
479433014219	Protein of unknown function (DUF3626); Region: DUF3626; pfam12294
479433014220	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433014221	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
479433014222	nucleotide binding site [chemical binding]; other site
479433014223	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
479433014224	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
479433014225	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
479433014226	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
479433014227	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
479433014228	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
479433014229	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
479433014230	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
479433014231	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433014232	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433014233	S-adenosylmethionine synthetase; Validated; Region: PRK05250
479433014234	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
479433014235	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
479433014236	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
479433014237	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
479433014238	Flavoprotein; Region: Flavoprotein; pfam02441
479433014239	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
479433014240	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
479433014241	AAA domain; Region: AAA_33; pfam13671
479433014242	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
479433014243	catalytic site [active]
479433014244	G-X2-G-X-G-K; other site
479433014245	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
479433014246	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
479433014247	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
479433014248	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
479433014249	metal ion-dependent adhesion site (MIDAS); other site
479433014250	hypothetical protein; Provisional; Region: PRK04262
479433014251	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
479433014252	acetyl-CoA acetyltransferase; Validated; Region: PRK06157
479433014253	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
479433014254	active site
479433014255	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
479433014256	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
479433014257	DNA binding residues [nucleotide binding]
479433014258	putative dimer interface [polypeptide binding]; other site
479433014259	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433014260	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433014261	active site
479433014262	catalytic tetrad [active]
479433014263	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
479433014264	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433014265	NB-ARC domain; Region: NB-ARC; pfam00931
479433014266	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433014267	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433014268	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433014269	active site
479433014270	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
479433014271	CoA-transferase family III; Region: CoA_transf_3; pfam02515
479433014272	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
479433014273	active site
479433014274	catalytic site [active]
479433014275	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
479433014276	active site 2 [active]
479433014277	active site 1 [active]
479433014278	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433014279	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433014280	active site
479433014281	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
479433014282	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
479433014283	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433014284	putative substrate translocation pore; other site
479433014285	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
479433014286	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
479433014287	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
479433014288	substrate binding pocket [chemical binding]; other site
479433014289	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
479433014290	B12 binding site [chemical binding]; other site
479433014291	cobalt ligand [ion binding]; other site
479433014292	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
479433014293	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433014294	non-specific DNA binding site [nucleotide binding]; other site
479433014295	salt bridge; other site
479433014296	sequence-specific DNA binding site [nucleotide binding]; other site
479433014297	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
479433014298	amidase catalytic site [active]
479433014299	Zn binding residues [ion binding]; other site
479433014300	substrate binding site [chemical binding]; other site
479433014301	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
479433014302	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
479433014303	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
479433014304	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
479433014305	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
479433014306	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
479433014307	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433014308	putative PBP binding loops; other site
479433014309	dimer interface [polypeptide binding]; other site
479433014310	ABC-ATPase subunit interface; other site
479433014311	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
479433014312	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433014313	ABC-ATPase subunit interface; other site
479433014314	putative PBP binding loops; other site
479433014315	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
479433014316	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433014317	Walker A/P-loop; other site
479433014318	ATP binding site [chemical binding]; other site
479433014319	Q-loop/lid; other site
479433014320	ABC transporter signature motif; other site
479433014321	Walker B; other site
479433014322	D-loop; other site
479433014323	H-loop/switch region; other site
479433014324	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
479433014325	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
479433014326	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433014327	Walker A/P-loop; other site
479433014328	ATP binding site [chemical binding]; other site
479433014329	Q-loop/lid; other site
479433014330	ABC transporter signature motif; other site
479433014331	Walker B; other site
479433014332	D-loop; other site
479433014333	H-loop/switch region; other site
479433014334	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
479433014335	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
479433014336	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
479433014337	CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans.  CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412
479433014338	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
479433014339	active site
479433014340	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
479433014341	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
479433014342	active site
479433014343	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
479433014344	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
479433014345	binding surface
479433014346	TPR motif; other site
479433014347	hypothetical protein; Provisional; Region: PRK08244
479433014348	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
479433014349	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
479433014350	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433014351	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
479433014352	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
479433014353	FAD binding pocket [chemical binding]; other site
479433014354	FAD binding motif [chemical binding]; other site
479433014355	phosphate binding motif [ion binding]; other site
479433014356	NAD binding pocket [chemical binding]; other site
479433014357	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
479433014358	Transcriptional regulator [Transcription]; Region: IclR; COG1414
479433014359	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
479433014360	Bacterial transcriptional regulator; Region: IclR; pfam01614
479433014361	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
479433014362	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433014363	hypothetical protein; Provisional; Region: PRK02487
479433014364	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433014365	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433014366	dimerization interface [polypeptide binding]; other site
479433014367	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433014368	dimer interface [polypeptide binding]; other site
479433014369	phosphorylation site [posttranslational modification]
479433014370	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433014371	ATP binding site [chemical binding]; other site
479433014372	Mg2+ binding site [ion binding]; other site
479433014373	G-X-G motif; other site
479433014374	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
479433014375	PAC2 family; Region: PAC2; pfam09754
479433014376	Predicted transcriptional regulators [Transcription]; Region: COG1733
479433014377	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
479433014378	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
479433014379	catalytic triad [active]
479433014380	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433014381	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433014382	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
479433014383	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
479433014384	active site
479433014385	HIGH motif; other site
479433014386	nucleotide binding site [chemical binding]; other site
479433014387	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
479433014388	active site
479433014389	KMSKS motif; other site
479433014390	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
479433014391	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433014392	Coenzyme A binding pocket [chemical binding]; other site
479433014393	conserved hypothetical protein; Region: TIGR03843
479433014394	conserved hypothetical protein; Region: TIGR03847
479433014395	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
479433014396	catalytic core [active]
479433014397	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
479433014398	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
479433014399	oligomer interface [polypeptide binding]; other site
479433014400	metal binding site [ion binding]; metal-binding site
479433014401	metal binding site [ion binding]; metal-binding site
479433014402	putative Cl binding site [ion binding]; other site
479433014403	basic sphincter; other site
479433014404	hydrophobic gate; other site
479433014405	periplasmic entrance; other site
479433014406	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
479433014407	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
479433014408	Methyltransferase small domain; Region: MTS; pfam05175
479433014409	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433014410	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433014411	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
479433014412	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
479433014413	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
479433014414	active site
479433014415	metal binding site [ion binding]; metal-binding site
479433014416	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
479433014417	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
479433014418	motif II; other site
479433014419	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
479433014420	dimer interface [polypeptide binding]; other site
479433014421	ADP-ribose binding site [chemical binding]; other site
479433014422	active site
479433014423	nudix motif; other site
479433014424	metal binding site [ion binding]; metal-binding site
479433014425	CTP synthetase; Validated; Region: pyrG; PRK05380
479433014426	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
479433014427	Catalytic site [active]
479433014428	active site
479433014429	UTP binding site [chemical binding]; other site
479433014430	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
479433014431	active site
479433014432	putative oxyanion hole; other site
479433014433	catalytic triad [active]
479433014434	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
479433014435	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
479433014436	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
479433014437	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
479433014438	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
479433014439	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433014440	DNA-binding site [nucleotide binding]; DNA binding site
479433014441	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
479433014442	UTRA domain; Region: UTRA; pfam07702
479433014443	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433014444	dimerization interface [polypeptide binding]; other site
479433014445	putative DNA binding site [nucleotide binding]; other site
479433014446	putative Zn2+ binding site [ion binding]; other site
479433014447	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
479433014448	Peptidase family M28; Region: Peptidase_M28; pfam04389
479433014449	metal binding site [ion binding]; metal-binding site
479433014450	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
479433014451	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433014452	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433014453	putative substrate translocation pore; other site
479433014454	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433014455	dimerization interface [polypeptide binding]; other site
479433014456	putative DNA binding site [nucleotide binding]; other site
479433014457	putative Zn2+ binding site [ion binding]; other site
479433014458	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
479433014459	amphipathic channel; other site
479433014460	Asn-Pro-Ala signature motifs; other site
479433014461	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
479433014462	Low molecular weight phosphatase family; Region: LMWPc; cd00115
479433014463	active site
479433014464	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
479433014465	Thiamine pyrophosphokinase; Region: TPK; cl08415
479433014466	Histidine kinase; Region: HisKA_3; pfam07730
479433014467	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433014468	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433014469	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433014470	active site
479433014471	phosphorylation site [posttranslational modification]
479433014472	intermolecular recognition site; other site
479433014473	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433014474	DNA binding residues [nucleotide binding]
479433014475	dimerization interface [polypeptide binding]; other site
479433014476	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
479433014477	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
479433014478	Walker A/P-loop; other site
479433014479	ATP binding site [chemical binding]; other site
479433014480	Q-loop/lid; other site
479433014481	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
479433014482	ABC transporter signature motif; other site
479433014483	Walker B; other site
479433014484	D-loop; other site
479433014485	H-loop/switch region; other site
479433014486	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
479433014487	ATP-NAD kinase; Region: NAD_kinase; pfam01513
479433014488	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
479433014489	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
479433014490	RNA binding surface [nucleotide binding]; other site
479433014491	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433014492	S-adenosylmethionine binding site [chemical binding]; other site
479433014493	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
479433014494	SCP-2 sterol transfer family; Region: SCP2; pfam02036
479433014495	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
479433014496	putative hydrophobic ligand binding site [chemical binding]; other site
479433014497	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433014498	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433014499	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
479433014500	CoA-transferase family III; Region: CoA_transf_3; pfam02515
479433014501	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
479433014502	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
479433014503	active site
479433014504	motif I; other site
479433014505	motif II; other site
479433014506	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
479433014507	TPR repeat; Region: TPR_11; pfam13414
479433014508	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433014509	binding surface
479433014510	TPR motif; other site
479433014511	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
479433014512	Uncharacterized conserved protein [Function unknown]; Region: COG4198
479433014513	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355
479433014514	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433014515	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
479433014516	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
479433014517	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
479433014518	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
479433014519	SPW repeat; Region: SPW; pfam03779
479433014520	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
479433014521	active site
479433014522	catalytic triad [active]
479433014523	oxyanion hole [active]
479433014524	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
479433014525	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
479433014526	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
479433014527	Walker A/P-loop; other site
479433014528	ATP binding site [chemical binding]; other site
479433014529	Q-loop/lid; other site
479433014530	ABC transporter signature motif; other site
479433014531	Walker B; other site
479433014532	D-loop; other site
479433014533	H-loop/switch region; other site
479433014534	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
479433014535	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
479433014536	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
479433014537	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433014538	Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243
479433014539	putative NAD(P) binding site [chemical binding]; other site
479433014540	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
479433014541	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
479433014542	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
479433014543	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
479433014544	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
479433014545	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
479433014546	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
479433014547	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
479433014548	motif II; other site
479433014549	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
479433014550	active site
479433014551	metal binding site [ion binding]; metal-binding site
479433014552	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
479433014553	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
479433014554	RNA binding surface [nucleotide binding]; other site
479433014555	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
479433014556	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
479433014557	NAD(P) binding site [chemical binding]; other site
479433014558	catalytic residues [active]
479433014559	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
479433014560	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
479433014561	active site
479433014562	HIGH motif; other site
479433014563	dimer interface [polypeptide binding]; other site
479433014564	KMSKS motif; other site
479433014565	S4 RNA-binding domain; Region: S4; smart00363
479433014566	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
479433014567	active site
479433014568	DNA binding site [nucleotide binding]
479433014569	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
479433014570	active site
479433014571	catalytic residues [active]
479433014572	argininosuccinate lyase; Provisional; Region: PRK00855
479433014573	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
479433014574	active sites [active]
479433014575	tetramer interface [polypeptide binding]; other site
479433014576	arginine repressor; Provisional; Region: PRK03341
479433014577	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
479433014578	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
479433014579	ornithine carbamoyltransferase; Provisional; Region: PRK00779
479433014580	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
479433014581	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
479433014582	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
479433014583	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
479433014584	inhibitor-cofactor binding pocket; inhibition site
479433014585	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433014586	catalytic residue [active]
479433014587	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
479433014588	feedback inhibition sensing region; other site
479433014589	homohexameric interface [polypeptide binding]; other site
479433014590	nucleotide binding site [chemical binding]; other site
479433014591	N-acetyl-L-glutamate binding site [chemical binding]; other site
479433014592	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
479433014593	heterotetramer interface [polypeptide binding]; other site
479433014594	active site pocket [active]
479433014595	cleavage site
479433014596	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
479433014597	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
479433014598	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
479433014599	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433014600	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433014601	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433014602	TPR motif; other site
479433014603	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433014604	binding surface
479433014605	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
479433014606	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433014607	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
479433014608	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433014609	S-adenosylmethionine binding site [chemical binding]; other site
479433014610	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
479433014611	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
479433014612	putative tRNA-binding site [nucleotide binding]; other site
479433014613	B3/4 domain; Region: B3_4; pfam03483
479433014614	tRNA synthetase B5 domain; Region: B5; pfam03484
479433014615	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
479433014616	dimer interface [polypeptide binding]; other site
479433014617	motif 1; other site
479433014618	motif 3; other site
479433014619	motif 2; other site
479433014620	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
479433014621	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
479433014622	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
479433014623	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
479433014624	dimer interface [polypeptide binding]; other site
479433014625	motif 1; other site
479433014626	active site
479433014627	motif 2; other site
479433014628	motif 3; other site
479433014629	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
479433014630	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433014631	dimer interface [polypeptide binding]; other site
479433014632	phosphorylation site [posttranslational modification]
479433014633	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433014634	ATP binding site [chemical binding]; other site
479433014635	Mg2+ binding site [ion binding]; other site
479433014636	G-X-G motif; other site
479433014637	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
479433014638	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
479433014639	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
479433014640	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
479433014641	23S rRNA binding site [nucleotide binding]; other site
479433014642	L21 binding site [polypeptide binding]; other site
479433014643	L13 binding site [polypeptide binding]; other site
479433014644	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
479433014645	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
479433014646	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
479433014647	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
479433014648	Protein of unknown function (DUF1342); Region: DUF1342; cl01892
479433014649	RibD C-terminal domain; Region: RibD_C; cl17279
479433014650	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
479433014651	active site
479433014652	catalytic residues [active]
479433014653	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813
479433014654	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
479433014655	active site
479433014656	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
479433014657	dimer interface [polypeptide binding]; other site
479433014658	substrate binding site [chemical binding]; other site
479433014659	catalytic residue [active]
479433014660	Predicted kinase [General function prediction only]; Region: COG0645
479433014661	polynucleotide kinase; Provisional; Region: pseT; PHA02530
479433014662	L-seryl-tRNA(Sec) kinase, eukaryotic; Region: selen_PSTK_euk; TIGR03575
479433014663	HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236
479433014664	RNA ligase; Region: RNA_lig_T4_1; pfam09511
479433014665	C2 domain; Region: C2; cl14603
479433014666	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
479433014667	putative active site [active]
479433014668	Uncharacterized conserved protein [Function unknown]; Region: COG4933
479433014669	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433014670	Coenzyme A binding pocket [chemical binding]; other site
479433014671	TIGR02679 family protein; Region: TIGR02679
479433014672	Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664
479433014673	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
479433014674	TIGR02680 family protein; Region: TIGR02680
479433014675	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
479433014676	Protein of unknown function (DUF2398); Region: DUF2398; cl09875
479433014677	Protein of unknown function (DUF2397); Region: DUF2397; pfam09660
479433014678	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433014679	AAA domain; Region: AAA_23; pfam13476
479433014680	Walker A/P-loop; other site
479433014681	ATP binding site [chemical binding]; other site
479433014682	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433014683	ABC transporter signature motif; other site
479433014684	Walker B; other site
479433014685	D-loop; other site
479433014686	TIGR02646 family protein; Region: TIGR02646
479433014687	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
479433014688	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
479433014689	active site
479433014690	metal binding site [ion binding]; metal-binding site
479433014691	DNA binding site [nucleotide binding]
479433014692	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
479433014693	AAA domain; Region: AAA_27; pfam13514
479433014694	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433014695	ABC transporter signature motif; other site
479433014696	Walker B; other site
479433014697	D-loop; other site
479433014698	H-loop/switch region; other site
479433014699	Domain of unknown function (DUF4209); Region: DUF4209; pfam13910
479433014700	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
479433014701	active site
479433014702	DNA binding site [nucleotide binding]
479433014703	Int/Topo IB signature motif; other site
479433014704	RNA ligase, DRB0094 family; Region: RNA_lig_DRB0094; TIGR02306
479433014705	The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320
479433014706	putative tRNA-binding site [nucleotide binding]; other site
479433014707	RNA ligase; Region: RNA_ligase; pfam09414
479433014708	polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075
479433014709	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
479433014710	active site
479433014711	metal binding site [ion binding]; metal-binding site
479433014712	RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623
479433014713	3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074
479433014714	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433014715	S-adenosylmethionine binding site [chemical binding]; other site
479433014716	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
479433014717	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
479433014718	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433014719	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
479433014720	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
479433014721	DNA binding residues [nucleotide binding]
479433014722	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
479433014723	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
479433014724	substrate binding site [chemical binding]; other site
479433014725	oxyanion hole (OAH) forming residues; other site
479433014726	trimer interface [polypeptide binding]; other site
479433014727	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
479433014728	homotrimer interaction site [polypeptide binding]; other site
479433014729	putative active site [active]
479433014730	salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255
479433014731	hypothetical protein; Provisional; Region: PRK07236
479433014732	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
479433014733	active site
479433014734	FMN binding site [chemical binding]; other site
479433014735	substrate binding site [chemical binding]; other site
479433014736	homotetramer interface [polypeptide binding]; other site
479433014737	catalytic residue [active]
479433014738	Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327
479433014739	PaaX-like protein; Region: PaaX; pfam07848
479433014740	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
479433014741	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433014742	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
479433014743	acyl-activating enzyme (AAE) consensus motif; other site
479433014744	AMP binding site [chemical binding]; other site
479433014745	active site
479433014746	CoA binding site [chemical binding]; other site
479433014747	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433014748	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433014749	active site
479433014750	Protein of unknown function (DUF402); Region: DUF402; pfam04167
479433014751	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
479433014752	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
479433014753	putative acyl-acceptor binding pocket; other site
479433014754	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
479433014755	active site
479433014756	Conserved TM helix; Region: TM_helix; pfam05552
479433014757	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
479433014758	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
479433014759	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433014760	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
479433014761	Coenzyme A binding pocket [chemical binding]; other site
479433014762	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
479433014763	active site
479433014764	catalytic site [active]
479433014765	substrate binding site [chemical binding]; other site
479433014766	Phosphotransferase enzyme family; Region: APH; pfam01636
479433014767	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
479433014768	substrate binding site [chemical binding]; other site
479433014769	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
479433014770	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
479433014771	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
479433014772	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433014773	catalytic residue [active]
479433014774	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433014775	dimerization interface [polypeptide binding]; other site
479433014776	putative DNA binding site [nucleotide binding]; other site
479433014777	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
479433014778	putative Zn2+ binding site [ion binding]; other site
479433014779	AsnC family; Region: AsnC_trans_reg; pfam01037
479433014780	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
479433014781	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
479433014782	active site
479433014783	Zn binding site [ion binding]; other site
479433014784	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
479433014785	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433014786	Coenzyme A binding pocket [chemical binding]; other site
479433014787	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
479433014788	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
479433014789	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433014790	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
479433014791	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
479433014792	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
479433014793	active site
479433014794	DNA binding site [nucleotide binding]
479433014795	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
479433014796	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433014797	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
479433014798	putative deacylase active site [active]
479433014799	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
479433014800	Beta-lactamase; Region: Beta-lactamase; pfam00144
479433014801	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433014802	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
479433014803	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
479433014804	nudix motif; other site
479433014805	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
479433014806	SPFH domain / Band 7 family; Region: Band_7; pfam01145
479433014807	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
479433014808	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
479433014809	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433014810	catalytic residue [active]
479433014811	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433014812	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433014813	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433014814	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433014815	putative substrate translocation pore; other site
479433014816	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433014817	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
479433014818	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433014819	RibD C-terminal domain; Region: RibD_C; cl17279
479433014820	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
479433014821	classical (c) SDRs; Region: SDR_c; cd05233
479433014822	NAD(P) binding site [chemical binding]; other site
479433014823	active site
479433014824	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433014825	salt bridge; other site
479433014826	non-specific DNA binding site [nucleotide binding]; other site
479433014827	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433014828	sequence-specific DNA binding site [nucleotide binding]; other site
479433014829	NIPSNAP; Region: NIPSNAP; pfam07978
479433014830	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433014831	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
479433014832	AAA domain; Region: AAA_33; pfam13671
479433014833	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
479433014834	active site
479433014835	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
479433014836	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
479433014837	Walker A/P-loop; other site
479433014838	ATP binding site [chemical binding]; other site
479433014839	Q-loop/lid; other site
479433014840	ABC transporter signature motif; other site
479433014841	Walker B; other site
479433014842	D-loop; other site
479433014843	H-loop/switch region; other site
479433014844	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
479433014845	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
479433014846	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
479433014847	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
479433014848	Protein of unknown function (DUF3224); Region: DUF3224; pfam11528
479433014849	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
479433014850	arginine-tRNA ligase; Region: PLN02286
479433014851	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
479433014852	active site
479433014853	HIGH motif; other site
479433014854	nucleotide binding site [chemical binding]; other site
479433014855	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
479433014856	KMSK motif region; other site
479433014857	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
479433014858	tRNA binding surface [nucleotide binding]; other site
479433014859	anticodon binding site; other site
479433014860	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433014861	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433014862	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433014863	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433014864	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
479433014865	metal ion-dependent adhesion site (MIDAS); other site
479433014866	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
479433014867	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433014868	NAD(P) binding site [chemical binding]; other site
479433014869	active site
479433014870	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
479433014871	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
479433014872	active site
479433014873	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
479433014874	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
479433014875	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
479433014876	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
479433014877	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
479433014878	ATP binding site [chemical binding]; other site
479433014879	putative Mg++ binding site [ion binding]; other site
479433014880	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
479433014881	nucleotide binding region [chemical binding]; other site
479433014882	ATP-binding site [chemical binding]; other site
479433014883	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
479433014884	active site
479433014885	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
479433014886	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
479433014887	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
479433014888	active site
479433014889	motif I; other site
479433014890	motif II; other site
479433014891	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
479433014892	Methyltransferase domain; Region: Methyltransf_31; pfam13847
479433014893	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433014894	S-adenosylmethionine binding site [chemical binding]; other site
479433014895	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
479433014896	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433014897	dimer interface [polypeptide binding]; other site
479433014898	conserved gate region; other site
479433014899	putative PBP binding loops; other site
479433014900	ABC-ATPase subunit interface; other site
479433014901	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
479433014902	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433014903	dimer interface [polypeptide binding]; other site
479433014904	conserved gate region; other site
479433014905	putative PBP binding loops; other site
479433014906	ABC-ATPase subunit interface; other site
479433014907	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
479433014908	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433014909	Walker A/P-loop; other site
479433014910	ATP binding site [chemical binding]; other site
479433014911	Q-loop/lid; other site
479433014912	ABC transporter signature motif; other site
479433014913	Walker B; other site
479433014914	D-loop; other site
479433014915	H-loop/switch region; other site
479433014916	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
479433014917	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
479433014918	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433014919	Walker A/P-loop; other site
479433014920	ATP binding site [chemical binding]; other site
479433014921	Q-loop/lid; other site
479433014922	ABC transporter signature motif; other site
479433014923	Walker B; other site
479433014924	D-loop; other site
479433014925	H-loop/switch region; other site
479433014926	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
479433014927	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
479433014928	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
479433014929	Methyltransferase domain; Region: Methyltransf_23; pfam13489
479433014930	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433014931	S-adenosylmethionine binding site [chemical binding]; other site
479433014932	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
479433014933	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
479433014934	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
479433014935	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
479433014936	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
479433014937	putative molybdopterin cofactor binding site [chemical binding]; other site
479433014938	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
479433014939	putative molybdopterin cofactor binding site; other site
479433014940	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
479433014941	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
479433014942	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433014943	active site
479433014944	phosphorylation site [posttranslational modification]
479433014945	intermolecular recognition site; other site
479433014946	dimerization interface [polypeptide binding]; other site
479433014947	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
479433014948	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
479433014949	PAS domain; Region: PAS; smart00091
479433014950	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433014951	ATP binding site [chemical binding]; other site
479433014952	Mg2+ binding site [ion binding]; other site
479433014953	G-X-G motif; other site
479433014954	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
479433014955	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
479433014956	Walker A/P-loop; other site
479433014957	ATP binding site [chemical binding]; other site
479433014958	Q-loop/lid; other site
479433014959	ABC transporter signature motif; other site
479433014960	Walker B; other site
479433014961	D-loop; other site
479433014962	H-loop/switch region; other site
479433014963	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
479433014964	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433014965	dimer interface [polypeptide binding]; other site
479433014966	conserved gate region; other site
479433014967	putative PBP binding loops; other site
479433014968	ABC-ATPase subunit interface; other site
479433014969	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
479433014970	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
479433014971	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433014972	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
479433014973	Preprotein translocase SecG subunit; Region: SecG; pfam03840
479433014974	triosephosphate isomerase; Provisional; Region: PRK14567
479433014975	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
479433014976	substrate binding site [chemical binding]; other site
479433014977	dimer interface [polypeptide binding]; other site
479433014978	catalytic triad [active]
479433014979	Phosphoglycerate kinase; Region: PGK; pfam00162
479433014980	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
479433014981	substrate binding site [chemical binding]; other site
479433014982	hinge regions; other site
479433014983	ADP binding site [chemical binding]; other site
479433014984	catalytic site [active]
479433014985	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
479433014986	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
479433014987	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
479433014988	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
479433014989	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
479433014990	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
479433014991	active site
479433014992	catalytic triad [active]
479433014993	oxyanion hole [active]
479433014994	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
479433014995	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
479433014996	phosphate binding site [ion binding]; other site
479433014997	putative substrate binding pocket [chemical binding]; other site
479433014998	dimer interface [polypeptide binding]; other site
479433014999	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
479433015000	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
479433015001	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
479433015002	GIY-YIG motif/motif A; other site
479433015003	active site
479433015004	catalytic site [active]
479433015005	putative DNA binding site [nucleotide binding]; other site
479433015006	metal binding site [ion binding]; metal-binding site
479433015007	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
479433015008	Helix-hairpin-helix motif; Region: HHH; pfam00633
479433015009	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
479433015010	iron-sulfur cluster [ion binding]; other site
479433015011	[2Fe-2S] cluster binding site [ion binding]; other site
479433015012	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
479433015013	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
479433015014	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
479433015015	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
479433015016	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
479433015017	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
479433015018	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
479433015019	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433015020	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433015021	active site
479433015022	ATP binding site [chemical binding]; other site
479433015023	substrate binding site [chemical binding]; other site
479433015024	activation loop (A-loop); other site
479433015025	choice-of-anchor B domain; Region: choice_anch_B; TIGR04312
479433015026	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
479433015027	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
479433015028	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
479433015029	active site
479433015030	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
479433015031	aromatic chitin/cellulose binding site residues [chemical binding]; other site
479433015032	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
479433015033	active site
479433015034	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
479433015035	aromatic chitin/cellulose binding site residues [chemical binding]; other site
479433015036	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433015037	NAD(P) binding site [chemical binding]; other site
479433015038	short chain dehydrogenase; Provisional; Region: PRK07024
479433015039	active site
479433015040	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
479433015041	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
479433015042	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
479433015043	NADH dehydrogenase subunit D; Validated; Region: PRK06075
479433015044	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
479433015045	active site
479433015046	dimer interface [polypeptide binding]; other site
479433015047	motif 1; other site
479433015048	motif 2; other site
479433015049	motif 3; other site
479433015050	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
479433015051	anticodon binding site; other site
479433015052	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
479433015053	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433015054	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
479433015055	Walker A/P-loop; other site
479433015056	ATP binding site [chemical binding]; other site
479433015057	Q-loop/lid; other site
479433015058	ABC transporter signature motif; other site
479433015059	Walker B; other site
479433015060	D-loop; other site
479433015061	H-loop/switch region; other site
479433015062	MarR family; Region: MarR_2; pfam12802
479433015063	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
479433015064	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433015065	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433015066	active site
479433015067	phosphorylation site [posttranslational modification]
479433015068	intermolecular recognition site; other site
479433015069	dimerization interface [polypeptide binding]; other site
479433015070	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433015071	DNA binding site [nucleotide binding]
479433015072	Penicillinase repressor; Region: Pencillinase_R; pfam03965
479433015073	Peptidase family M48; Region: Peptidase_M48; cl12018
479433015074	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
479433015075	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
479433015076	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433015077	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
479433015078	DNA binding residues [nucleotide binding]
479433015079	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433015080	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433015081	putative substrate translocation pore; other site
479433015082	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
479433015083	ABC1 family; Region: ABC1; cl17513
479433015084	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
479433015085	active site
479433015086	ATP binding site [chemical binding]; other site
479433015087	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433015088	substrate binding site [chemical binding]; other site
479433015089	activation loop (A-loop); other site
479433015090	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
479433015091	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
479433015092	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
479433015093	hypothetical protein; Provisional; Region: PRK02947
479433015094	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
479433015095	putative active site [active]
479433015096	PAC2 family; Region: PAC2; pfam09754
479433015097	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
479433015098	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
479433015099	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
479433015100	excinuclease ABC subunit B; Provisional; Region: PRK05298
479433015101	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
479433015102	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
479433015103	nucleotide binding region [chemical binding]; other site
479433015104	ATP-binding site [chemical binding]; other site
479433015105	Ultra-violet resistance protein B; Region: UvrB; pfam12344
479433015106	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433015107	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
479433015108	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
479433015109	active site
479433015110	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433015111	sugar binding site [chemical binding]; other site
479433015112	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433015113	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433015114	putative sugar binding sites [chemical binding]; other site
479433015115	Q-X-W motif; other site
479433015116	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
479433015117	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433015118	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
479433015119	Coenzyme A binding pocket [chemical binding]; other site
479433015120	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820
479433015121	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433015122	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433015123	putative sugar binding sites [chemical binding]; other site
479433015124	Q-X-W motif; other site
479433015125	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820
479433015126	putative sugar binding sites [chemical binding]; other site
479433015127	Q-X-W motif; other site
479433015128	Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200
479433015129	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
479433015130	Putative Ig domain; Region: He_PIG; pfam05345
479433015131	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433015132	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433015133	Q-X-W motif; other site
479433015134	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820
479433015135	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
479433015136	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433015137	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
479433015138	Walker A motif; other site
479433015139	ATP binding site [chemical binding]; other site
479433015140	Walker B motif; other site
479433015141	arginine finger; other site
479433015142	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
479433015143	Cupin domain; Region: Cupin_2; pfam07883
479433015144	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
479433015145	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
479433015146	active site
479433015147	non-prolyl cis peptide bond; other site
479433015148	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
479433015149	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433015150	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
479433015151	NAD(P) binding site [chemical binding]; other site
479433015152	active site
479433015153	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
479433015154	FAD binding domain; Region: FAD_binding_4; pfam01565
479433015155	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
479433015156	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
479433015157	UbiA prenyltransferase family; Region: UbiA; pfam01040
479433015158	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
479433015159	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
479433015160	CoA-binding site [chemical binding]; other site
479433015161	ATP-binding [chemical binding]; other site
479433015162	translocation protein TolB; Provisional; Region: tolB; PRK02889
479433015163	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433015164	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433015165	putative substrate translocation pore; other site
479433015166	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
479433015167	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
479433015168	RNA binding site [nucleotide binding]; other site
479433015169	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
479433015170	RNA binding site [nucleotide binding]; other site
479433015171	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
479433015172	RNA binding site [nucleotide binding]; other site
479433015173	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
479433015174	RNA binding site [nucleotide binding]; other site
479433015175	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433015176	S-adenosylmethionine binding site [chemical binding]; other site
479433015177	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
479433015178	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
479433015179	DNA polymerase I; Provisional; Region: PRK05755
479433015180	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
479433015181	active site
479433015182	metal binding site 1 [ion binding]; metal-binding site
479433015183	putative 5' ssDNA interaction site; other site
479433015184	metal binding site 3; metal-binding site
479433015185	metal binding site 2 [ion binding]; metal-binding site
479433015186	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
479433015187	putative DNA binding site [nucleotide binding]; other site
479433015188	putative metal binding site [ion binding]; other site
479433015189	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
479433015190	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
479433015191	active site
479433015192	DNA binding site [nucleotide binding]
479433015193	catalytic site [active]
479433015194	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
479433015195	CoenzymeA binding site [chemical binding]; other site
479433015196	subunit interaction site [polypeptide binding]; other site
479433015197	PHB binding site; other site
479433015198	Phosphotransferase enzyme family; Region: APH; pfam01636
479433015199	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
479433015200	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
479433015201	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
479433015202	Walker A/P-loop; other site
479433015203	ATP binding site [chemical binding]; other site
479433015204	Q-loop/lid; other site
479433015205	ABC transporter signature motif; other site
479433015206	Walker B; other site
479433015207	D-loop; other site
479433015208	H-loop/switch region; other site
479433015209	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
479433015210	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
479433015211	Walker A/P-loop; other site
479433015212	ATP binding site [chemical binding]; other site
479433015213	Q-loop/lid; other site
479433015214	ABC transporter signature motif; other site
479433015215	Walker B; other site
479433015216	D-loop; other site
479433015217	H-loop/switch region; other site
479433015218	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
479433015219	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
479433015220	TM-ABC transporter signature motif; other site
479433015221	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
479433015222	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
479433015223	TM-ABC transporter signature motif; other site
479433015224	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
479433015225	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
479433015226	dimerization interface [polypeptide binding]; other site
479433015227	ligand binding site [chemical binding]; other site
479433015228	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
479433015229	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433015230	active site
479433015231	phosphorylation site [posttranslational modification]
479433015232	intermolecular recognition site; other site
479433015233	dimerization interface [polypeptide binding]; other site
479433015234	ANTAR domain; Region: ANTAR; pfam03861
479433015235	Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276
479433015236	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
479433015237	G1 box; other site
479433015238	putative GEF interaction site [polypeptide binding]; other site
479433015239	GTP/Mg2+ binding site [chemical binding]; other site
479433015240	Switch I region; other site
479433015241	G2 box; other site
479433015242	G3 box; other site
479433015243	Switch II region; other site
479433015244	G4 box; other site
479433015245	G5 box; other site
479433015246	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
479433015247	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
479433015248	selenocysteine synthase; Provisional; Region: PRK04311
479433015249	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
479433015250	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
479433015251	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
479433015252	dimerization interface [polypeptide binding]; other site
479433015253	putative ATP binding site [chemical binding]; other site
479433015254	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
479433015255	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433015256	NB-ARC domain; Region: NB-ARC; pfam00931
479433015257	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433015258	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433015259	TPR motif; other site
479433015260	binding surface
479433015261	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433015262	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433015263	binding surface
479433015264	TPR motif; other site
479433015265	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433015266	RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468
479433015267	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
479433015268	pyruvate kinase; Provisional; Region: PRK06247
479433015269	domain interfaces; other site
479433015270	active site
479433015271	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
479433015272	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
479433015273	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
479433015274	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
479433015275	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
479433015276	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
479433015277	active site
479433015278	dimer interface [polypeptide binding]; other site
479433015279	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
479433015280	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
479433015281	active site
479433015282	FMN binding site [chemical binding]; other site
479433015283	substrate binding site [chemical binding]; other site
479433015284	3Fe-4S cluster binding site [ion binding]; other site
479433015285	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
479433015286	domain interface; other site
479433015287	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
479433015288	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
479433015289	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
479433015290	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
479433015291	catalytic residues [active]
479433015292	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
479433015293	Thioredoxin; Region: Thioredoxin_4; cl17273
479433015294	Methylamine utilisation protein MauE; Region: MauE; pfam07291
479433015295	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
479433015296	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
479433015297	substrate binding site [chemical binding]; other site
479433015298	active site
479433015299	catalytic residues [active]
479433015300	heterodimer interface [polypeptide binding]; other site
479433015301	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
479433015302	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
479433015303	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433015304	catalytic residue [active]
479433015305	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
479433015306	active site
479433015307	ribulose/triose binding site [chemical binding]; other site
479433015308	phosphate binding site [ion binding]; other site
479433015309	substrate (anthranilate) binding pocket [chemical binding]; other site
479433015310	product (indole) binding pocket [chemical binding]; other site
479433015311	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850
479433015312	anthranilate synthase component I; Provisional; Region: PRK13571
479433015313	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
479433015314	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
479433015315	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
479433015316	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
479433015317	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
479433015318	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
479433015319	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433015320	Walker A/P-loop; other site
479433015321	ATP binding site [chemical binding]; other site
479433015322	Q-loop/lid; other site
479433015323	ABC transporter signature motif; other site
479433015324	Walker B; other site
479433015325	D-loop; other site
479433015326	H-loop/switch region; other site
479433015327	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
479433015328	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
479433015329	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433015330	Walker A/P-loop; other site
479433015331	ATP binding site [chemical binding]; other site
479433015332	Q-loop/lid; other site
479433015333	ABC transporter signature motif; other site
479433015334	Walker B; other site
479433015335	D-loop; other site
479433015336	H-loop/switch region; other site
479433015337	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433015338	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433015339	active site
479433015340	phosphorylation site [posttranslational modification]
479433015341	intermolecular recognition site; other site
479433015342	dimerization interface [polypeptide binding]; other site
479433015343	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433015344	dimerization interface [polypeptide binding]; other site
479433015345	DNA binding residues [nucleotide binding]
479433015346	Histidine kinase; Region: HisKA_3; pfam07730
479433015347	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433015348	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
479433015349	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
479433015350	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433015351	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
479433015352	Walker A/P-loop; other site
479433015353	ATP binding site [chemical binding]; other site
479433015354	Q-loop/lid; other site
479433015355	ABC transporter signature motif; other site
479433015356	Walker B; other site
479433015357	D-loop; other site
479433015358	H-loop/switch region; other site
479433015359	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
479433015360	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
479433015361	substrate binding site [chemical binding]; other site
479433015362	glutamase interaction surface [polypeptide binding]; other site
479433015363	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
479433015364	homotrimer interaction site [polypeptide binding]; other site
479433015365	putative active site [active]
479433015366	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
479433015367	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
479433015368	catalytic residues [active]
479433015369	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
479433015370	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
479433015371	putative active site [active]
479433015372	oxyanion strand; other site
479433015373	catalytic triad [active]
479433015374	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
479433015375	putative active site pocket [active]
479433015376	4-fold oligomerization interface [polypeptide binding]; other site
479433015377	metal binding residues [ion binding]; metal-binding site
479433015378	3-fold/trimer interface [polypeptide binding]; other site
479433015379	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
479433015380	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
479433015381	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433015382	homodimer interface [polypeptide binding]; other site
479433015383	catalytic residue [active]
479433015384	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
479433015385	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
479433015386	NAD binding site [chemical binding]; other site
479433015387	dimerization interface [polypeptide binding]; other site
479433015388	product binding site; other site
479433015389	substrate binding site [chemical binding]; other site
479433015390	zinc binding site [ion binding]; other site
479433015391	catalytic residues [active]
479433015392	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
479433015393	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
479433015394	putative deacylase active site [active]
479433015395	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
479433015396	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
479433015397	RNA binding surface [nucleotide binding]; other site
479433015398	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
479433015399	active site
479433015400	lipoprotein signal peptidase; Provisional; Region: PRK14764
479433015401	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
479433015402	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
479433015403	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
479433015404	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
479433015405	active site
479433015406	HIGH motif; other site
479433015407	nucleotide binding site [chemical binding]; other site
479433015408	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
479433015409	active site
479433015410	KMSKS motif; other site
479433015411	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
479433015412	tRNA binding surface [nucleotide binding]; other site
479433015413	anticodon binding site; other site
479433015414	Uncharacterized conserved protein [Function unknown]; Region: COG1432
479433015415	LabA_like proteins; Region: LabA_like; cd06167
479433015416	putative metal binding site [ion binding]; other site
479433015417	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
479433015418	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
479433015419	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433015420	Phosphotransferase enzyme family; Region: APH; pfam01636
479433015421	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
479433015422	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
479433015423	putative active site [active]
479433015424	putative catalytic site [active]
479433015425	putative DNA binding site [nucleotide binding]; other site
479433015426	putative phosphate binding site [ion binding]; other site
479433015427	metal binding site A [ion binding]; metal-binding site
479433015428	putative AP binding site [nucleotide binding]; other site
479433015429	putative metal binding site B [ion binding]; other site
479433015430	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
479433015431	Family description; Region: VCBS; pfam13517
479433015432	Family description; Region: VCBS; pfam13517
479433015433	Family description; Region: VCBS; pfam13517
479433015434	Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256
479433015435	Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255
479433015436	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
479433015437	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
479433015438	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
479433015439	Methyltransferase domain; Region: Methyltransf_31; pfam13847
479433015440	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433015441	S-adenosylmethionine binding site [chemical binding]; other site
479433015442	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
479433015443	active site flap/lid [active]
479433015444	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433015445	nucleophilic elbow; other site
479433015446	catalytic triad [active]
479433015447	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
479433015448	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
479433015449	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
479433015450	putative substrate binding site [chemical binding]; other site
479433015451	putative ATP binding site [chemical binding]; other site
479433015452	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433015453	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433015454	DNA binding site [nucleotide binding]
479433015455	domain linker motif; other site
479433015456	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433015457	dimerization interface [polypeptide binding]; other site
479433015458	ligand binding site [chemical binding]; other site
479433015459	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
479433015460	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
479433015461	ligand binding site [chemical binding]; other site
479433015462	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
479433015463	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
479433015464	TM-ABC transporter signature motif; other site
479433015465	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
479433015466	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433015467	Walker A/P-loop; other site
479433015468	ATP binding site [chemical binding]; other site
479433015469	Q-loop/lid; other site
479433015470	ABC transporter signature motif; other site
479433015471	Walker B; other site
479433015472	D-loop; other site
479433015473	H-loop/switch region; other site
479433015474	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433015475	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433015476	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
479433015477	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433015478	dimer interface [polypeptide binding]; other site
479433015479	putative PBP binding loops; other site
479433015480	ABC-ATPase subunit interface; other site
479433015481	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433015482	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433015483	dimer interface [polypeptide binding]; other site
479433015484	conserved gate region; other site
479433015485	putative PBP binding loops; other site
479433015486	ABC-ATPase subunit interface; other site
479433015487	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433015488	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433015489	DNA binding site [nucleotide binding]
479433015490	domain linker motif; other site
479433015491	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433015492	dimerization interface [polypeptide binding]; other site
479433015493	ligand binding site [chemical binding]; other site
479433015494	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433015495	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433015496	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
479433015497	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
479433015498	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433015499	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
479433015500	dimerization interface [polypeptide binding]; other site
479433015501	short chain dehydrogenase; Provisional; Region: PRK12744
479433015502	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433015503	NAD(P) binding site [chemical binding]; other site
479433015504	active site
479433015505	Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979
479433015506	active site
479433015507	Predicted transcriptional regulators [Transcription]; Region: COG1733
479433015508	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
479433015509	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433015510	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433015511	active site
479433015512	catalytic tetrad [active]
479433015513	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433015514	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
479433015515	HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; pfam03767
479433015516	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433015517	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
479433015518	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433015519	NAD(P) binding site [chemical binding]; other site
479433015520	active site
479433015521	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433015522	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433015523	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433015524	DNA binding residues [nucleotide binding]
479433015525	Tim44-like domain; Region: Tim44; cl09208
479433015526	Uncharacterized conserved protein [Function unknown]; Region: COG1359
479433015527	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
479433015528	Domain of unknown function DUF21; Region: DUF21; pfam01595
479433015529	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
479433015530	Transporter associated domain; Region: CorC_HlyC; smart01091
479433015531	Domain of unknown function DUF21; Region: DUF21; pfam01595
479433015532	FOG: CBS domain [General function prediction only]; Region: COG0517
479433015533	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
479433015534	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433015535	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433015536	DNA binding residues [nucleotide binding]
479433015537	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
479433015538	EF-hand domain pair; Region: EF_hand_5; pfam13499
479433015539	Ca2+ binding site [ion binding]; other site
479433015540	Muconolactone delta-isomerase; Region: MIase; pfam02426
479433015541	Muconolactone delta-isomerase; Region: MIase; cl01992
479433015542	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
479433015543	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
479433015544	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433015545	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433015546	active site
479433015547	phosphorylation site [posttranslational modification]
479433015548	intermolecular recognition site; other site
479433015549	dimerization interface [polypeptide binding]; other site
479433015550	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433015551	DNA binding site [nucleotide binding]
479433015552	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433015553	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433015554	dimerization interface [polypeptide binding]; other site
479433015555	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433015556	dimer interface [polypeptide binding]; other site
479433015557	phosphorylation site [posttranslational modification]
479433015558	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433015559	ATP binding site [chemical binding]; other site
479433015560	Mg2+ binding site [ion binding]; other site
479433015561	G-X-G motif; other site
479433015562	Predicted transcriptional regulators [Transcription]; Region: COG1695
479433015563	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
479433015564	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
479433015565	D-alanine--D-lactate ligase; Provisional; Region: vanB; PRK14568
479433015566	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
479433015567	ATP-grasp domain; Region: ATP-grasp_4; cl17255
479433015568	Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185
479433015569	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
479433015570	putative ligand binding site [chemical binding]; other site
479433015571	putative NAD binding site [chemical binding]; other site
479433015572	catalytic site [active]
479433015573	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
479433015574	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
479433015575	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
479433015576	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
479433015577	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
479433015578	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433015579	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
479433015580	sequence-specific DNA binding site [nucleotide binding]; other site
479433015581	salt bridge; other site
479433015582	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433015583	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433015584	active site
479433015585	ATP binding site [chemical binding]; other site
479433015586	substrate binding site [chemical binding]; other site
479433015587	activation loop (A-loop); other site
479433015588	Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563
479433015589	active site triad [active]
479433015590	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
479433015591	EamA-like transporter family; Region: EamA; pfam00892
479433015592	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433015593	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433015594	SnoaL-like domain; Region: SnoaL_4; pfam13577
479433015595	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319
479433015596	gating phenylalanine in ion channel; other site
479433015597	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
479433015598	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
479433015599	Cl- selectivity filter; other site
479433015600	Cl- binding residues [ion binding]; other site
479433015601	pore gating glutamate residue; other site
479433015602	dimer interface [polypeptide binding]; other site
479433015603	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
479433015604	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
479433015605	peptidase domain interface [polypeptide binding]; other site
479433015606	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
479433015607	active site
479433015608	catalytic triad [active]
479433015609	calcium binding site [ion binding]; other site
479433015610	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433015611	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433015612	Protein of unknown function (DUF3533); Region: DUF3533; pfam12051
479433015613	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
479433015614	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
479433015615	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433015616	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
479433015617	Walker A/P-loop; other site
479433015618	ATP binding site [chemical binding]; other site
479433015619	Q-loop/lid; other site
479433015620	ABC transporter signature motif; other site
479433015621	Walker B; other site
479433015622	D-loop; other site
479433015623	H-loop/switch region; other site
479433015624	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433015625	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
479433015626	Walker A/P-loop; other site
479433015627	ATP binding site [chemical binding]; other site
479433015628	Q-loop/lid; other site
479433015629	ABC transporter signature motif; other site
479433015630	Walker B; other site
479433015631	D-loop; other site
479433015632	H-loop/switch region; other site
479433015633	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433015634	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
479433015635	putative NAD(P) binding site [chemical binding]; other site
479433015636	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433015637	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433015638	thymidylate synthase; Reviewed; Region: thyA; PRK01827
479433015639	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
479433015640	dimerization interface [polypeptide binding]; other site
479433015641	active site
479433015642	Methyltransferase domain; Region: Methyltransf_31; pfam13847
479433015643	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433015644	S-adenosylmethionine binding site [chemical binding]; other site
479433015645	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433015646	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433015647	sequence-specific DNA binding site [nucleotide binding]; other site
479433015648	salt bridge; other site
479433015649	Cupin domain; Region: Cupin_2; pfam07883
479433015650	Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719
479433015651	Sm and related proteins; Region: Sm_like; cl00259
479433015652	Sm1 motif; other site
479433015653	hexamer interface [polypeptide binding]; other site
479433015654	RNA binding site [nucleotide binding]; other site
479433015655	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433015656	dimerization interface [polypeptide binding]; other site
479433015657	putative DNA binding site [nucleotide binding]; other site
479433015658	putative Zn2+ binding site [ion binding]; other site
479433015659	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
479433015660	hypothetical protein; Validated; Region: PRK06201
479433015661	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
479433015662	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
479433015663	active site
479433015664	DNA binding site [nucleotide binding]
479433015665	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
479433015666	DNA binding site [nucleotide binding]
479433015667	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
479433015668	nucleotide binding site [chemical binding]; other site
479433015669	DNA polymerase IV; Validated; Region: PRK03352
479433015670	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
479433015671	active site
479433015672	DNA binding site [nucleotide binding]
479433015673	Predicted transcriptional regulators [Transcription]; Region: COG1733
479433015674	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
479433015675	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
479433015676	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433015677	NAD(P) binding site [chemical binding]; other site
479433015678	active site
479433015679	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
479433015680	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
479433015681	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
479433015682	DNA binding site [nucleotide binding]
479433015683	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433015684	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433015685	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
479433015686	Walker A/P-loop; other site
479433015687	ATP binding site [chemical binding]; other site
479433015688	Q-loop/lid; other site
479433015689	ABC transporter signature motif; other site
479433015690	Walker B; other site
479433015691	D-loop; other site
479433015692	H-loop/switch region; other site
479433015693	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
479433015694	Catalytic site [active]
479433015695	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
479433015696	DNA binding site [nucleotide binding]
479433015697	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433015698	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433015699	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433015700	binding surface
479433015701	TPR motif; other site
479433015702	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433015703	MarR family; Region: MarR; pfam01047
479433015704	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
479433015705	NADPH bind site [chemical binding]; other site
479433015706	putative FMN binding site [chemical binding]; other site
479433015707	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
479433015708	FMN binding site [chemical binding]; other site
479433015709	dimer interface [polypeptide binding]; other site
479433015710	Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458
479433015711	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
479433015712	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
479433015713	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
479433015714	Hemerythrin-like domain; Region: Hr-like; cd12108
479433015715	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
479433015716	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433015717	Walker A/P-loop; other site
479433015718	ATP binding site [chemical binding]; other site
479433015719	Q-loop/lid; other site
479433015720	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433015721	ABC transporter signature motif; other site
479433015722	Walker B; other site
479433015723	D-loop; other site
479433015724	H-loop/switch region; other site
479433015725	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433015726	Walker A/P-loop; other site
479433015727	ATP binding site [chemical binding]; other site
479433015728	Q-loop/lid; other site
479433015729	ABC transporter signature motif; other site
479433015730	Walker B; other site
479433015731	D-loop; other site
479433015732	H-loop/switch region; other site
479433015733	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
479433015734	DNA binding residues [nucleotide binding]
479433015735	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
479433015736	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
479433015737	DNA binding residues [nucleotide binding]
479433015738	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433015739	Methyltransferase domain; Region: Methyltransf_31; pfam13847
479433015740	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433015741	S-adenosylmethionine binding site [chemical binding]; other site
479433015742	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424
479433015743	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
479433015744	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
479433015745	active site
479433015746	peptide synthase; Provisional; Region: PRK12316
479433015747	Alpha amylase catalytic domain found in maltogenic amylases, cyclodextrin glycosyltransferase, and related proteins; Region: AmyAc_AmyMalt_CGTase_like; cd11320
479433015748	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
479433015749	Ca binding site [ion binding]; other site
479433015750	active site
479433015751	catalytic site [active]
479433015752	Aamy_C domain; Region: Aamy_C; smart00632
479433015753	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
479433015754	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347
479433015755	starch-binding site 2 [chemical binding]; other site
479433015756	starch-binding site 1 [chemical binding]; other site
479433015757	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433015758	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433015759	dimer interface [polypeptide binding]; other site
479433015760	conserved gate region; other site
479433015761	putative PBP binding loops; other site
479433015762	ABC-ATPase subunit interface; other site
479433015763	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433015764	dimer interface [polypeptide binding]; other site
479433015765	conserved gate region; other site
479433015766	putative PBP binding loops; other site
479433015767	ABC-ATPase subunit interface; other site
479433015768	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433015769	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
479433015770	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433015771	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433015772	DNA binding site [nucleotide binding]
479433015773	domain linker motif; other site
479433015774	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292
479433015775	putative dimerization interface [polypeptide binding]; other site
479433015776	putative ligand binding site [chemical binding]; other site
479433015777	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
479433015778	homodimer interface [polypeptide binding]; other site
479433015779	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
479433015780	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
479433015781	active site
479433015782	homodimer interface [polypeptide binding]; other site
479433015783	catalytic site [active]
479433015784	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
479433015785	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
479433015786	active site
479433015787	catalytic site [active]
479433015788	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
479433015789	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663
479433015790	SxDxEG motif; other site
479433015791	active site
479433015792	metal binding site [ion binding]; metal-binding site
479433015793	homopentamer interface [polypeptide binding]; other site
479433015794	active site 1 [active]
479433015795	dimer interface [polypeptide binding]; other site
479433015796	hexamer interface [polypeptide binding]; other site
479433015797	active site 2 [active]
479433015798	Tautomerase enzyme; Region: Tautomerase; pfam01361
479433015799	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433015800	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433015801	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
479433015802	dimerization interface [polypeptide binding]; other site
479433015803	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433015804	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
479433015805	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
479433015806	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
479433015807	active site
479433015808	DNA binding site [nucleotide binding]
479433015809	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
479433015810	DNA binding site [nucleotide binding]
479433015811	Predicted eukaryotic-type DNA primase [DNA replication, recombination, and repair]; Region: COG3285
479433015812	nucleotide binding site [chemical binding]; other site
479433015813	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433015814	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
479433015815	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433015816	S-adenosylmethionine binding site [chemical binding]; other site
479433015817	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
479433015818	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
479433015819	Domain of unknown function (DUF385); Region: DUF385; pfam04075
479433015820	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
479433015821	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
479433015822	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433015823	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433015824	Walker A/P-loop; other site
479433015825	ATP binding site [chemical binding]; other site
479433015826	Q-loop/lid; other site
479433015827	ABC transporter signature motif; other site
479433015828	Walker B; other site
479433015829	D-loop; other site
479433015830	H-loop/switch region; other site
479433015831	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433015832	Histidine kinase; Region: HisKA_3; pfam07730
479433015833	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433015834	ATP binding site [chemical binding]; other site
479433015835	Mg2+ binding site [ion binding]; other site
479433015836	G-X-G motif; other site
479433015837	Response regulator receiver domain; Region: Response_reg; pfam00072
479433015838	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433015839	active site
479433015840	phosphorylation site [posttranslational modification]
479433015841	intermolecular recognition site; other site
479433015842	dimerization interface [polypeptide binding]; other site
479433015843	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433015844	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433015845	DNA binding residues [nucleotide binding]
479433015846	dimerization interface [polypeptide binding]; other site
479433015847	YCII-related domain; Region: YCII; cl00999
479433015848	Beta-lactamase; Region: Beta-lactamase; pfam00144
479433015849	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
479433015850	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
479433015851	active site
479433015852	metal binding site [ion binding]; metal-binding site
479433015853	RNB domain; Region: RNB; pfam00773
479433015854	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
479433015855	Predicted transcriptional regulators [Transcription]; Region: COG1695
479433015856	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
479433015857	hypothetical protein; Validated; Region: PRK02101
479433015858	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
479433015859	RNA/DNA hybrid binding site [nucleotide binding]; other site
479433015860	active site
479433015861	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
479433015862	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
479433015863	catalytic core [active]
479433015864	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
479433015865	Putative zinc ribbon domain; Region: DUF164; pfam02591
479433015866	Uncharacterized conserved protein [Function unknown]; Region: COG0327
479433015867	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
479433015868	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433015869	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
479433015870	putative NAD(P) binding site [chemical binding]; other site
479433015871	DNA polymerase II large subunit; Provisional; Region: PRK14714
479433015872	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792
479433015873	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433015874	NAD(P) binding site [chemical binding]; other site
479433015875	active site
479433015876	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
479433015877	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
479433015878	NAD binding site [chemical binding]; other site
479433015879	catalytic Zn binding site [ion binding]; other site
479433015880	substrate binding site [chemical binding]; other site
479433015881	structural Zn binding site [ion binding]; other site
479433015882	enoyl-CoA hydratase; Region: PLN02864
479433015883	Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452
479433015884	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
479433015885	dimer interaction site [polypeptide binding]; other site
479433015886	substrate-binding tunnel; other site
479433015887	active site
479433015888	catalytic site [active]
479433015889	substrate binding site [chemical binding]; other site
479433015890	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
479433015891	CoenzymeA binding site [chemical binding]; other site
479433015892	subunit interaction site [polypeptide binding]; other site
479433015893	PHB binding site; other site
479433015894	FOG: WD40 repeat [General function prediction only]; Region: COG2319
479433015895	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
479433015896	structural tetrad; other site
479433015897	Cation efflux family; Region: Cation_efflux; pfam01545
479433015898	acyl-CoA synthetase; Validated; Region: PRK07867
479433015899	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433015900	acyl-activating enzyme (AAE) consensus motif; other site
479433015901	AMP binding site [chemical binding]; other site
479433015902	active site
479433015903	CoA binding site [chemical binding]; other site
479433015904	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433015905	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
479433015906	dimerization interface [polypeptide binding]; other site
479433015907	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
479433015908	short chain dehydrogenase; Provisional; Region: PRK07454
479433015909	NADP binding site [chemical binding]; other site
479433015910	substrate binding site [chemical binding]; other site
479433015911	active site
479433015912	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433015913	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433015914	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433015915	MarR family; Region: MarR; pfam01047
479433015916	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
479433015917	intersubunit interface [polypeptide binding]; other site
479433015918	active site
479433015919	zinc binding site [ion binding]; other site
479433015920	Na+ binding site [ion binding]; other site
479433015921	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
479433015922	putative substrate binding site [chemical binding]; other site
479433015923	putative ATP binding site [chemical binding]; other site
479433015924	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433015925	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
479433015926	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
479433015927	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
479433015928	dimer interface [polypeptide binding]; other site
479433015929	active site
479433015930	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
479433015931	dimer interface [polypeptide binding]; other site
479433015932	active site
479433015933	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
479433015934	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433015935	putative DNA binding site [nucleotide binding]; other site
479433015936	putative Zn2+ binding site [ion binding]; other site
479433015937	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
479433015938	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
479433015939	aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159
479433015940	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
479433015941	Dimer interface [polypeptide binding]; other site
479433015942	anticodon binding site; other site
479433015943	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
479433015944	motif 1; other site
479433015945	dimer interface [polypeptide binding]; other site
479433015946	active site
479433015947	motif 2; other site
479433015948	motif 3; other site
479433015949	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
479433015950	proline aminopeptidase P II; Provisional; Region: PRK10879
479433015951	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
479433015952	active site
479433015953	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
479433015954	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433015955	DNA-binding site [nucleotide binding]; DNA binding site
479433015956	FCD domain; Region: FCD; pfam07729
479433015957	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
479433015958	Proline racemase; Region: Pro_racemase; pfam05544
479433015959	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
479433015960	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
479433015961	inhibitor site; inhibition site
479433015962	active site
479433015963	dimer interface [polypeptide binding]; other site
479433015964	catalytic residue [active]
479433015965	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
479433015966	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
479433015967	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
479433015968	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
479433015969	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
479433015970	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
479433015971	ligand binding site [chemical binding]; other site
479433015972	flexible hinge region; other site
479433015973	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
479433015974	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
479433015975	substrate binding pocket [chemical binding]; other site
479433015976	chain length determination region; other site
479433015977	substrate-Mg2+ binding site; other site
479433015978	catalytic residues [active]
479433015979	aspartate-rich region 1; other site
479433015980	active site lid residues [active]
479433015981	aspartate-rich region 2; other site
479433015982	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
479433015983	amino acid permease (GABA permease); Region: 2A0304; TIGR00907
479433015984	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
479433015985	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
479433015986	active site
479433015987	metal binding site [ion binding]; metal-binding site
479433015988	nudix motif; other site
479433015989	bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975
479433015990	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444
479433015991	active site
479433015992	DNA binding site [nucleotide binding]
479433015993	catalytic site [active]
479433015994	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433015995	malonic semialdehyde reductase; Provisional; Region: PRK10538
479433015996	NAD(P) binding site [chemical binding]; other site
479433015997	active site
479433015998	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
479433015999	EamA-like transporter family; Region: EamA; pfam00892
479433016000	EamA-like transporter family; Region: EamA; pfam00892
479433016001	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
479433016002	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
479433016003	Lysine efflux permease [General function prediction only]; Region: COG1279
479433016004	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
479433016005	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433016006	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
479433016007	dimerization interface [polypeptide binding]; other site
479433016008	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433016009	Predicted flavoprotein [General function prediction only]; Region: COG0431
479433016010	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
479433016011	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
479433016012	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433016013	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
479433016014	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
479433016015	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433016016	Walker A/P-loop; other site
479433016017	ATP binding site [chemical binding]; other site
479433016018	Q-loop/lid; other site
479433016019	ABC transporter signature motif; other site
479433016020	Walker B; other site
479433016021	D-loop; other site
479433016022	H-loop/switch region; other site
479433016023	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
479433016024	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
479433016025	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
479433016026	Walker A/P-loop; other site
479433016027	ATP binding site [chemical binding]; other site
479433016028	Q-loop/lid; other site
479433016029	ABC transporter signature motif; other site
479433016030	Walker B; other site
479433016031	D-loop; other site
479433016032	H-loop/switch region; other site
479433016033	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
479433016034	Lipase (class 2); Region: Lipase_2; pfam01674
479433016035	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
479433016036	nucleotide binding site/active site [active]
479433016037	HIT family signature motif; other site
479433016038	catalytic residue [active]
479433016039	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433016040	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433016041	DNA binding site [nucleotide binding]
479433016042	domain linker motif; other site
479433016043	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433016044	dimerization interface [polypeptide binding]; other site
479433016045	ligand binding site [chemical binding]; other site
479433016046	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
479433016047	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
479433016048	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433016049	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433016050	putative sugar binding sites [chemical binding]; other site
479433016051	Q-X-W motif; other site
479433016052	probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856
479433016053	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433016054	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
479433016055	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433016056	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433016057	active site
479433016058	ATP binding site [chemical binding]; other site
479433016059	substrate binding site [chemical binding]; other site
479433016060	activation loop (A-loop); other site
479433016061	acyl-CoA synthetase; Validated; Region: PRK08316
479433016062	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433016063	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
479433016064	acyl-activating enzyme (AAE) consensus motif; other site
479433016065	putative AMP binding site [chemical binding]; other site
479433016066	putative active site [active]
479433016067	putative CoA binding site [chemical binding]; other site
479433016068	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433016069	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433016070	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
479433016071	putative dimerization interface [polypeptide binding]; other site
479433016072	MarR family; Region: MarR_2; pfam12802
479433016073	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433016074	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
479433016075	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
479433016076	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
479433016077	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
479433016078	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
479433016079	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
479433016080	TM-ABC transporter signature motif; other site
479433016081	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
479433016082	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
479433016083	Walker A/P-loop; other site
479433016084	ATP binding site [chemical binding]; other site
479433016085	Q-loop/lid; other site
479433016086	ABC transporter signature motif; other site
479433016087	Walker B; other site
479433016088	D-loop; other site
479433016089	H-loop/switch region; other site
479433016090	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
479433016091	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
479433016092	putative ligand binding site [chemical binding]; other site
479433016093	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
479433016094	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
479433016095	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
479433016096	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433016097	aminotransferase; Validated; Region: PRK07777
479433016098	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
479433016099	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433016100	homodimer interface [polypeptide binding]; other site
479433016101	catalytic residue [active]
479433016102	AAA domain; Region: AAA_18; pfam13238
479433016103	AAA domain; Region: AAA_17; pfam13207
479433016104	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
479433016105	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
479433016106	Phosphoesterase family; Region: Phosphoesterase; pfam04185
479433016107	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433016108	putative DNA binding site [nucleotide binding]; other site
479433016109	putative Zn2+ binding site [ion binding]; other site
479433016110	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
479433016111	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
479433016112	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
479433016113	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
479433016114	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
479433016115	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
479433016116	Uncharacterized conserved protein [Function unknown]; Region: COG2128
479433016117	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
479433016118	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
479433016119	active site
479433016120	dimer interface [polypeptide binding]; other site
479433016121	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
479433016122	Ligand Binding Site [chemical binding]; other site
479433016123	Molecular Tunnel; other site
479433016124	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
479433016125	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
479433016126	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
479433016127	Cysteine-rich domain; Region: CCG; pfam02754
479433016128	Cysteine-rich domain; Region: CCG; pfam02754
479433016129	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
479433016130	catalytic site [active]
479433016131	putative active site [active]
479433016132	putative substrate binding site [chemical binding]; other site
479433016133	dimer interface [polypeptide binding]; other site
479433016134	Cupin domain; Region: Cupin_2; pfam07883
479433016135	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
479433016136	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
479433016137	conserved cys residue [active]
479433016138	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
479433016139	FAD binding domain; Region: FAD_binding_4; pfam01565
479433016140	FAD binding domain; Region: FAD_binding_4; pfam01565
479433016141	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
479433016142	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433016143	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433016144	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
479433016145	Phosphotransferase enzyme family; Region: APH; pfam01636
479433016146	putative active site [active]
479433016147	putative substrate binding site [chemical binding]; other site
479433016148	ATP binding site [chemical binding]; other site
479433016149	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
479433016150	classical (c) SDRs; Region: SDR_c; cd05233
479433016151	NAD(P) binding site [chemical binding]; other site
479433016152	active site
479433016153	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
479433016154	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
479433016155	inhibitor-cofactor binding pocket; inhibition site
479433016156	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433016157	catalytic residue [active]
479433016158	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
479433016159	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
479433016160	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
479433016161	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433016162	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433016163	active site
479433016164	catalytic tetrad [active]
479433016165	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424
479433016166	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433016167	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
479433016168	NAD(P) binding site [chemical binding]; other site
479433016169	active site
479433016170	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433016171	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433016172	hypothetical protein; Provisional; Region: PRK06208
479433016173	intersubunit interface [polypeptide binding]; other site
479433016174	active site
479433016175	Zn2+ binding site [ion binding]; other site
479433016176	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
479433016177	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
479433016178	Interdomain contacts; other site
479433016179	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
479433016180	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
479433016181	putative active site [active]
479433016182	Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141
479433016183	putative RNAase interaction site [polypeptide binding]; other site
479433016184	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
479433016185	active site
479433016186	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
479433016187	thiamine phosphate binding site [chemical binding]; other site
479433016188	active site
479433016189	pyrophosphate binding site [ion binding]; other site
479433016190	Helix-turn-helix domain; Region: HTH_17; cl17695
479433016191	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
479433016192	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
479433016193	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
479433016194	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
479433016195	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
479433016196	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
479433016197	thiS-thiF/thiG interaction site; other site
479433016198	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
479433016199	ThiS interaction site; other site
479433016200	putative active site [active]
479433016201	tetramer interface [polypeptide binding]; other site
479433016202	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
479433016203	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433016204	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433016205	active site
479433016206	ATP binding site [chemical binding]; other site
479433016207	substrate binding site [chemical binding]; other site
479433016208	activation loop (A-loop); other site
479433016209	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433016210	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
479433016211	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
479433016212	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
479433016213	GAF domain; Region: GAF; pfam01590
479433016214	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
479433016215	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433016216	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433016217	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
479433016218	EamA-like transporter family; Region: EamA; pfam00892
479433016219	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
479433016220	MarR family; Region: MarR; pfam01047
479433016221	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433016222	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433016223	putative substrate translocation pore; other site
479433016224	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
479433016225	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
479433016226	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
479433016227	A new structural DNA glycosylase; Region: AlkD_like; cl11434
479433016228	active site
479433016229	MarR family; Region: MarR; pfam01047
479433016230	MarR family; Region: MarR_2; cl17246
479433016231	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
479433016232	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433016233	putative DNA binding site [nucleotide binding]; other site
479433016234	putative Zn2+ binding site [ion binding]; other site
479433016235	cobyric acid synthase; Provisional; Region: PRK00784
479433016236	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
479433016237	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
479433016238	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
479433016239	catalytic triad [active]
479433016240	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433016241	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433016242	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
479433016243	putative dimerization interface [polypeptide binding]; other site
479433016244	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
479433016245	EamA-like transporter family; Region: EamA; pfam00892
479433016246	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
479433016247	AAA domain; Region: AAA_30; pfam13604
479433016248	Family description; Region: UvrD_C_2; pfam13538
479433016249	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
479433016250	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433016251	catalytic residue [active]
479433016252	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
479433016253	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
479433016254	hypothetical protein; Provisional; Region: PRK07908
479433016255	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
479433016256	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433016257	homodimer interface [polypeptide binding]; other site
479433016258	catalytic residue [active]
479433016259	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
479433016260	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
479433016261	putative active site [active]
479433016262	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
479433016263	putative active site [active]
479433016264	Precorrin-8X methylmutase; Region: CbiC; pfam02570
479433016265	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
479433016266	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
479433016267	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
479433016268	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
479433016269	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
479433016270	active site
479433016271	SAM binding site [chemical binding]; other site
479433016272	homodimer interface [polypeptide binding]; other site
479433016273	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
479433016274	active site
479433016275	SAM binding site [chemical binding]; other site
479433016276	putative homodimer interface [polypeptide binding]; other site
479433016277	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
479433016278	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
479433016279	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
479433016280	active site
479433016281	SAM binding site [chemical binding]; other site
479433016282	homodimer interface [polypeptide binding]; other site
479433016283	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
479433016284	homodimer interface [polypeptide binding]; other site
479433016285	active site
479433016286	SAM binding site [chemical binding]; other site
479433016287	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
479433016288	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
479433016289	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
479433016290	catalytic triad [active]
479433016291	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
479433016292	cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986
479433016293	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
479433016294	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
479433016295	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
479433016296	metal ion-dependent adhesion site (MIDAS); other site
479433016297	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
479433016298	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
479433016299	Moco binding site; other site
479433016300	metal coordination site [ion binding]; other site
479433016301	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
479433016302	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
479433016303	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
479433016304	heme binding site [chemical binding]; other site
479433016305	ferroxidase pore; other site
479433016306	ferroxidase diiron center [ion binding]; other site
479433016307	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
479433016308	ATP binding site [chemical binding]; other site
479433016309	G-X-G motif; other site
479433016310	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433016311	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433016312	active site
479433016313	phosphorylation site [posttranslational modification]
479433016314	intermolecular recognition site; other site
479433016315	dimerization interface [polypeptide binding]; other site
479433016316	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433016317	DNA binding residues [nucleotide binding]
479433016318	dimerization interface [polypeptide binding]; other site
479433016319	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
479433016320	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
479433016321	tetramer interface [polypeptide binding]; other site
479433016322	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433016323	catalytic residue [active]
479433016324	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
479433016325	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433016326	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433016327	active site
479433016328	phosphorylation site [posttranslational modification]
479433016329	intermolecular recognition site; other site
479433016330	dimerization interface [polypeptide binding]; other site
479433016331	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433016332	DNA binding residues [nucleotide binding]
479433016333	dimerization interface [polypeptide binding]; other site
479433016334	Histidine kinase; Region: HisKA_3; pfam07730
479433016335	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433016336	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
479433016337	Strictosidine synthase; Region: Str_synth; pfam03088
479433016338	phosphofructokinase; Region: PFK_mixed; TIGR02483
479433016339	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
479433016340	active site
479433016341	ADP/pyrophosphate binding site [chemical binding]; other site
479433016342	dimerization interface [polypeptide binding]; other site
479433016343	allosteric effector site; other site
479433016344	fructose-1,6-bisphosphate binding site; other site
479433016345	Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403
479433016346	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
479433016347	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
479433016348	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
479433016349	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433016350	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433016351	active site
479433016352	phosphorylation site [posttranslational modification]
479433016353	intermolecular recognition site; other site
479433016354	dimerization interface [polypeptide binding]; other site
479433016355	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433016356	DNA binding residues [nucleotide binding]
479433016357	dimerization interface [polypeptide binding]; other site
479433016358	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433016359	Histidine kinase; Region: HisKA_3; pfam07730
479433016360	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433016361	ATP binding site [chemical binding]; other site
479433016362	G-X-G motif; other site
479433016363	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
479433016364	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
479433016365	putative acyl-acceptor binding pocket; other site
479433016366	Esterase/lipase [General function prediction only]; Region: COG1647
479433016367	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
479433016368	EamA-like transporter family; Region: EamA; pfam00892
479433016369	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
479433016370	putative catalytic site [active]
479433016371	putative phosphate binding site [ion binding]; other site
479433016372	putative metal binding site [ion binding]; other site
479433016373	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
479433016374	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
479433016375	nucleotide binding site [chemical binding]; other site
479433016376	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
479433016377	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
479433016378	putative hydrophobic ligand binding site [chemical binding]; other site
479433016379	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
479433016380	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
479433016381	acyl-activating enzyme (AAE) consensus motif; other site
479433016382	putative AMP binding site [chemical binding]; other site
479433016383	putative active site [active]
479433016384	putative CoA binding site [chemical binding]; other site
479433016385	Phosphotransferase enzyme family; Region: APH; pfam01636
479433016386	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
479433016387	substrate binding site [chemical binding]; other site
479433016388	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433016389	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433016390	putative Zn2+ binding site [ion binding]; other site
479433016391	putative DNA binding site [nucleotide binding]; other site
479433016392	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433016393	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
479433016394	Walker A/P-loop; other site
479433016395	ATP binding site [chemical binding]; other site
479433016396	Q-loop/lid; other site
479433016397	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433016398	ABC transporter signature motif; other site
479433016399	Walker B; other site
479433016400	D-loop; other site
479433016401	H-loop/switch region; other site
479433016402	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433016403	Walker A/P-loop; other site
479433016404	ATP binding site [chemical binding]; other site
479433016405	Q-loop/lid; other site
479433016406	ABC transporter signature motif; other site
479433016407	Walker B; other site
479433016408	D-loop; other site
479433016409	H-loop/switch region; other site
479433016410	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433016411	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433016412	active site
479433016413	catalytic tetrad [active]
479433016414	YCII-related domain; Region: YCII; cl00999
479433016415	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
479433016416	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
479433016417	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
479433016418	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433016419	Cytochrome P450; Region: p450; cl12078
479433016420	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433016421	Short C-terminal domain; Region: SHOCT; pfam09851
479433016422	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433016423	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433016424	active site
479433016425	ATP binding site [chemical binding]; other site
479433016426	substrate binding site [chemical binding]; other site
479433016427	activation loop (A-loop); other site
479433016428	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
479433016429	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
479433016430	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
479433016431	catalytic site [active]
479433016432	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433016433	dimerization interface [polypeptide binding]; other site
479433016434	putative DNA binding site [nucleotide binding]; other site
479433016435	putative Zn2+ binding site [ion binding]; other site
479433016436	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433016437	sequence-specific DNA binding site [nucleotide binding]; other site
479433016438	salt bridge; other site
479433016439	putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730
479433016440	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433016441	NAD(P) binding site [chemical binding]; other site
479433016442	active site
479433016443	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
479433016444	Predicted transcriptional regulators [Transcription]; Region: COG1733
479433016445	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
479433016446	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433016447	MarR family; Region: MarR; pfam01047
479433016448	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
479433016449	substrate binding site [chemical binding]; other site
479433016450	Beta-lactamase; Region: Beta-lactamase; pfam00144
479433016451	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
479433016452	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433016453	Histidine kinase; Region: HisKA_3; pfam07730
479433016454	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433016455	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433016456	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433016457	active site
479433016458	phosphorylation site [posttranslational modification]
479433016459	intermolecular recognition site; other site
479433016460	dimerization interface [polypeptide binding]; other site
479433016461	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433016462	DNA binding residues [nucleotide binding]
479433016463	dimerization interface [polypeptide binding]; other site
479433016464	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
479433016465	NlpC/P60 family; Region: NLPC_P60; pfam00877
479433016466	YacP-like NYN domain; Region: NYN_YacP; cl01491
479433016467	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
479433016468	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
479433016469	AsnC family; Region: AsnC_trans_reg; pfam01037
479433016470	DivIVA protein; Region: DivIVA; pfam05103
479433016471	DivIVA domain; Region: DivI1A_domain; TIGR03544
479433016472	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
479433016473	Protein of unknown function (DUF552); Region: DUF552; pfam04472
479433016474	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
479433016475	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
479433016476	catalytic residue [active]
479433016477	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
479433016478	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
479433016479	cell division protein FtsZ; Validated; Region: PRK09330
479433016480	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
479433016481	nucleotide binding site [chemical binding]; other site
479433016482	SulA interaction site; other site
479433016483	cell division protein FtsQ; Provisional; Region: PRK05529
479433016484	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
479433016485	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
479433016486	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433016487	DNA-binding site [nucleotide binding]; DNA binding site
479433016488	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
479433016489	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433016490	homodimer interface [polypeptide binding]; other site
479433016491	catalytic residue [active]
479433016492	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
479433016493	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
479433016494	active site
479433016495	catalytic residues [active]
479433016496	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
479433016497	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
479433016498	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
479433016499	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
479433016500	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
479433016501	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
479433016502	active site
479433016503	homodimer interface [polypeptide binding]; other site
479433016504	cell division protein FtsW; Region: ftsW; TIGR02614
479433016505	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
479433016506	EamA-like transporter family; Region: EamA; pfam00892
479433016507	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
479433016508	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433016509	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
479433016510	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438
479433016511	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
479433016512	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
479433016513	TIGR03086 family protein; Region: TIGR03086
479433016514	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
479433016515	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
479433016516	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
479433016517	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433016518	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433016519	SnoaL-like domain; Region: SnoaL_2; pfam12680
479433016520	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
479433016521	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433016522	S-adenosylmethionine binding site [chemical binding]; other site
479433016523	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
479433016524	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
479433016525	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
479433016526	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
479433016527	Predicted membrane protein [Function unknown]; Region: COG4280
479433016528	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
479433016529	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
479433016530	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
479433016531	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
479433016532	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
479433016533	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
479433016534	DNA binding residues [nucleotide binding]
479433016535	Putative zinc-finger; Region: zf-HC2; pfam13490
479433016536	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
479433016537	Glyco_18 domain; Region: Glyco_18; smart00636
479433016538	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
479433016539	active site
479433016540	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
479433016541	aromatic chitin/cellulose binding site residues [chemical binding]; other site
479433016542	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
479433016543	aromatic chitin/cellulose binding site residues [chemical binding]; other site
479433016544	Glyco_18 domain; Region: Glyco_18; smart00636
479433016545	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
479433016546	active site
479433016547	haloalkane dehalogenase; Provisional; Region: PRK03592
479433016548	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
479433016549	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
479433016550	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
479433016551	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433016552	DNA binding residues [nucleotide binding]
479433016553	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
479433016554	ATP binding site [chemical binding]; other site
479433016555	AAA domain; Region: AAA_17; cl17253
479433016556	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
479433016557	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
479433016558	active site
479433016559	ApbE family; Region: ApbE; pfam02424
479433016560	FMN-binding domain; Region: FMN_bind; cl01081
479433016561	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
479433016562	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
479433016563	FMN reductase; Validated; Region: fre; PRK08051
479433016564	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
479433016565	FAD binding pocket [chemical binding]; other site
479433016566	FAD binding motif [chemical binding]; other site
479433016567	phosphate binding motif [ion binding]; other site
479433016568	beta-alpha-beta structure motif; other site
479433016569	NAD binding pocket [chemical binding]; other site
479433016570	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433016571	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433016572	active site
479433016573	phosphorylation site [posttranslational modification]
479433016574	intermolecular recognition site; other site
479433016575	dimerization interface [polypeptide binding]; other site
479433016576	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433016577	DNA binding site [nucleotide binding]
479433016578	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
479433016579	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433016580	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433016581	dimer interface [polypeptide binding]; other site
479433016582	phosphorylation site [posttranslational modification]
479433016583	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433016584	ATP binding site [chemical binding]; other site
479433016585	Mg2+ binding site [ion binding]; other site
479433016586	G-X-G motif; other site
479433016587	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433016588	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
479433016589	Walker A/P-loop; other site
479433016590	ATP binding site [chemical binding]; other site
479433016591	Q-loop/lid; other site
479433016592	ABC transporter signature motif; other site
479433016593	Walker B; other site
479433016594	D-loop; other site
479433016595	H-loop/switch region; other site
479433016596	Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109
479433016597	dimer interface [polypeptide binding]; other site
479433016598	Citrate synthase; Region: Citrate_synt; pfam00285
479433016599	active site
479433016600	citrylCoA binding site [chemical binding]; other site
479433016601	oxalacetate/citrate binding site [chemical binding]; other site
479433016602	coenzyme A binding site [chemical binding]; other site
479433016603	catalytic triad [active]
479433016604	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433016605	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
479433016606	active site
479433016607	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
479433016608	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433016609	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433016610	active site
479433016611	catalytic tetrad [active]
479433016612	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433016613	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433016614	Walker A/P-loop; other site
479433016615	ATP binding site [chemical binding]; other site
479433016616	Q-loop/lid; other site
479433016617	ABC transporter signature motif; other site
479433016618	Walker B; other site
479433016619	D-loop; other site
479433016620	H-loop/switch region; other site
479433016621	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200
479433016622	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
479433016623	Phosphoesterase family; Region: Phosphoesterase; pfam04185
479433016624	FOG: PKD repeat [General function prediction only]; Region: COG3291
479433016625	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
479433016626	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
479433016627	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
479433016628	Interdomain contacts; other site
479433016629	Cytokine receptor motif; other site
479433016630	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
479433016631	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
479433016632	Domain of unknown function (DUF4291); Region: DUF4291; pfam14124
479433016633	Domain of unknown function (DUF385); Region: DUF385; pfam04075
479433016634	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
479433016635	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
479433016636	putative catalytic site [active]
479433016637	putative metal binding site [ion binding]; other site
479433016638	putative phosphate binding site [ion binding]; other site
479433016639	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
479433016640	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
479433016641	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433016642	Walker A/P-loop; other site
479433016643	ATP binding site [chemical binding]; other site
479433016644	Q-loop/lid; other site
479433016645	ABC transporter signature motif; other site
479433016646	Walker B; other site
479433016647	D-loop; other site
479433016648	H-loop/switch region; other site
479433016649	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
479433016650	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
479433016651	conserved cys residue [active]
479433016652	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433016653	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433016654	putative substrate translocation pore; other site
479433016655	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433016656	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
479433016657	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
479433016658	E3 interaction surface; other site
479433016659	lipoyl attachment site [posttranslational modification]; other site
479433016660	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
479433016661	e3 binding domain; Region: E3_binding; pfam02817
479433016662	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
479433016663	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
479433016664	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
479433016665	alpha subunit interface [polypeptide binding]; other site
479433016666	TPP binding site [chemical binding]; other site
479433016667	heterodimer interface [polypeptide binding]; other site
479433016668	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
479433016669	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
479433016670	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
479433016671	tetramer interface [polypeptide binding]; other site
479433016672	TPP-binding site [chemical binding]; other site
479433016673	heterodimer interface [polypeptide binding]; other site
479433016674	phosphorylation loop region [posttranslational modification]
479433016675	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
479433016676	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433016677	putative DNA binding site [nucleotide binding]; other site
479433016678	putative Zn2+ binding site [ion binding]; other site
479433016679	AsnC family; Region: AsnC_trans_reg; pfam01037
479433016680	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
479433016681	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
479433016682	nitrite reductase subunit NirD; Provisional; Region: PRK14989
479433016683	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
479433016684	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
479433016685	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
479433016686	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
479433016687	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
479433016688	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
479433016689	[4Fe-4S] binding site [ion binding]; other site
479433016690	molybdopterin cofactor binding site; other site
479433016691	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
479433016692	molybdopterin cofactor binding site; other site
479433016693	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
479433016694	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
479433016695	active site
479433016696	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433016697	DNA binding site [nucleotide binding]
479433016698	Phosphotransferase enzyme family; Region: APH; pfam01636
479433016699	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
479433016700	active site
479433016701	ATP binding site [chemical binding]; other site
479433016702	antibiotic binding site [chemical binding]; other site
479433016703	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433016704	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433016705	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433016706	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
479433016707	acyl-activating enzyme (AAE) consensus motif; other site
479433016708	AMP binding site [chemical binding]; other site
479433016709	active site
479433016710	CoA binding site [chemical binding]; other site
479433016711	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
479433016712	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
479433016713	dimer interface [polypeptide binding]; other site
479433016714	active site
479433016715	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
479433016716	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
479433016717	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
479433016718	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
479433016719	phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288
479433016720	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
479433016721	NAD(P) binding site [chemical binding]; other site
479433016722	catalytic residues [active]
479433016723	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
479433016724	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
479433016725	substrate binding site [chemical binding]; other site
479433016726	oxyanion hole (OAH) forming residues; other site
479433016727	trimer interface [polypeptide binding]; other site
479433016728	Chloramphenicol phosphotransferase-like protein; Region: CPT; pfam07931
479433016729	P-loop motif; other site
479433016730	ATP binding site [chemical binding]; other site
479433016731	Chloramphenicol (Cm) binding site [chemical binding]; other site
479433016732	catalytic residue [active]
479433016733	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
479433016734	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433016735	Coenzyme A binding pocket [chemical binding]; other site
479433016736	Cytochrome P450; Region: p450; cl12078
479433016737	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433016738	Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417
479433016739	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
479433016740	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433016741	S-adenosylmethionine binding site [chemical binding]; other site
479433016742	Domain of unknown function (DUF4265); Region: DUF4265; pfam14085
479433016743	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
479433016744	propionate/acetate kinase; Provisional; Region: PRK12379
479433016745	phosphate acetyltransferase; Reviewed; Region: PRK05632
479433016746	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
479433016747	DRTGG domain; Region: DRTGG; pfam07085
479433016748	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
479433016749	putative phosphoketolase; Provisional; Region: PRK05261
479433016750	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
479433016751	TPP-binding site; other site
479433016752	XFP C-terminal domain; Region: XFP_C; pfam09363
479433016753	Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687
479433016754	substrate binding pocket [chemical binding]; other site
479433016755	substrate-Mg2+ binding site; other site
479433016756	aspartate-rich region 1; other site
479433016757	active site lid residues [active]
479433016758	aspartate-rich region 2; other site
479433016759	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
479433016760	substrate binding pocket [chemical binding]; other site
479433016761	substrate-Mg2+ binding site; other site
479433016762	aspartate-rich region 1; other site
479433016763	aspartate-rich region 2; other site
479433016764	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844
479433016765	active site
479433016766	catalytic triad [active]
479433016767	oxyanion hole [active]
479433016768	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433016769	Coenzyme A binding pocket [chemical binding]; other site
479433016770	Domain of unknown function (DUF385); Region: DUF385; cl04387
479433016771	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
479433016772	PAS domain; Region: PAS; smart00091
479433016773	PAS fold; Region: PAS_4; pfam08448
479433016774	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
479433016775	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
479433016776	metal binding site [ion binding]; metal-binding site
479433016777	active site
479433016778	I-site; other site
479433016779	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
479433016780	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
479433016781	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
479433016782	metal binding site [ion binding]; metal-binding site
479433016783	active site
479433016784	I-site; other site
479433016785	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
479433016786	active site
479433016787	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
479433016788	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
479433016789	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
479433016790	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
479433016791	active site
479433016792	Cupin domain; Region: Cupin_2; cl17218
479433016793	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
479433016794	Methyltransferase domain; Region: Methyltransf_12; pfam08242
479433016795	Helix-turn-helix domain; Region: HTH_31; pfam13560
479433016796	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433016797	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
479433016798	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433016799	Cupin domain; Region: Cupin_2; cl17218
479433016800	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
479433016801	FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
479433016802	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
479433016803	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
479433016804	NAD binding site [chemical binding]; other site
479433016805	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
479433016806	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433016807	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
479433016808	dimerization interface [polypeptide binding]; other site
479433016809	putative transporter; Provisional; Region: PRK12382
479433016810	major facilitator superfamily transporter; Provisional; Region: PRK05122
479433016811	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433016812	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433016813	DNA binding residues [nucleotide binding]
479433016814	dimerization interface [polypeptide binding]; other site
479433016815	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433016816	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433016817	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
479433016818	SnoaL-like domain; Region: SnoaL_3; pfam13474
479433016819	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433016820	Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243
479433016821	putative NAD(P) binding site [chemical binding]; other site
479433016822	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433016823	Cupin domain; Region: Cupin_2; pfam07883
479433016824	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433016825	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433016826	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433016827	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433016828	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
479433016829	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
479433016830	putative NAD(P) binding site [chemical binding]; other site
479433016831	putative active site [active]
479433016832	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
479433016833	Predicted membrane protein [Function unknown]; Region: COG4270
479433016834	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
479433016835	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
479433016836	OsmC-like protein; Region: OsmC; pfam02566
479433016837	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
479433016838	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
479433016839	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
479433016840	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
479433016841	homodimer interface [polypeptide binding]; other site
479433016842	substrate-cofactor binding pocket; other site
479433016843	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433016844	catalytic residue [active]
479433016845	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
479433016846	Domain of unknown function (DUF4041); Region: DUF4041; pfam13250
479433016847	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
479433016848	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
479433016849	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
479433016850	NlpC/P60 family; Region: NLPC_P60; cl17555
479433016851	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
479433016852	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
479433016853	CGNR zinc finger; Region: zf-CGNR; pfam11706
479433016854	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433016855	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
479433016856	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
479433016857	MOSC domain; Region: MOSC; pfam03473
479433016858	alpha-galactosidase; Region: PLN02808; cl17638
479433016859	Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200
479433016860	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433016861	Q-X-W motif; other site
479433016862	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433016863	putative sugar binding sites [chemical binding]; other site
479433016864	Ricin-type beta-trefoil; Region: RICIN; smart00458
479433016865	Q-X-W motif; other site
479433016866	Predicted ATPase [General function prediction only]; Region: COG4637
479433016867	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433016868	Walker A/P-loop; other site
479433016869	ATP binding site [chemical binding]; other site
479433016870	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
479433016871	Short C-terminal domain; Region: SHOCT; pfam09851
479433016872	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
479433016873	Membrane protein of unknown function; Region: DUF360; pfam04020
479433016874	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
479433016875	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
479433016876	Phosphoesterase family; Region: Phosphoesterase; pfam04185
479433016877	Imelysin; Region: Peptidase_M75; pfam09375
479433016878	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
479433016879	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
479433016880	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
479433016881	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
479433016882	DNA binding site [nucleotide binding]
479433016883	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433016884	Predicted ATPase [General function prediction only]; Region: COG3903
479433016885	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
479433016886	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
479433016887	NodB motif; other site
479433016888	active site
479433016889	catalytic site [active]
479433016890	metal binding site [ion binding]; metal-binding site
479433016891	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
479433016892	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
479433016893	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
479433016894	CysD dimerization site [polypeptide binding]; other site
479433016895	G1 box; other site
479433016896	putative GEF interaction site [polypeptide binding]; other site
479433016897	GTP/Mg2+ binding site [chemical binding]; other site
479433016898	Switch I region; other site
479433016899	G2 box; other site
479433016900	G3 box; other site
479433016901	Switch II region; other site
479433016902	G4 box; other site
479433016903	G5 box; other site
479433016904	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
479433016905	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
479433016906	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
479433016907	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
479433016908	Active Sites [active]
479433016909	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433016910	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
479433016911	NAD(P) binding site [chemical binding]; other site
479433016912	active site
479433016913	HlyD family secretion protein; Region: HlyD_3; pfam13437
479433016914	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
479433016915	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
479433016916	DXD motif; other site
479433016917	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
479433016918	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433016919	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433016920	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433016921	DNA binding residues [nucleotide binding]
479433016922	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
479433016923	hypothetical protein; Provisional; Region: PRK07236
479433016924	hypothetical protein; Provisional; Region: PRK07588
479433016925	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
479433016926	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433016927	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433016928	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
479433016929	active site
479433016930	metal binding site [ion binding]; metal-binding site
479433016931	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
479433016932	Prostaglandin dehydrogenases; Region: PGDH; cd05288
479433016933	NAD(P) binding site [chemical binding]; other site
479433016934	dimer interface [polypeptide binding]; other site
479433016935	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433016936	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433016937	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433016938	TPR motif; other site
479433016939	binding surface
479433016940	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433016941	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433016942	active site
479433016943	phosphorylation site [posttranslational modification]
479433016944	intermolecular recognition site; other site
479433016945	dimerization interface [polypeptide binding]; other site
479433016946	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433016947	DNA binding residues [nucleotide binding]
479433016948	dimerization interface [polypeptide binding]; other site
479433016949	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433016950	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433016951	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433016952	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433016953	active site
479433016954	Condensation domain; Region: Condensation; pfam00668
479433016955	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
479433016956	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
479433016957	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
479433016958	acyl-activating enzyme (AAE) consensus motif; other site
479433016959	AMP binding site [chemical binding]; other site
479433016960	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433016961	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
479433016962	M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653
479433016963	acetyl-lysine deacetylase; Provisional; Region: PRK04443
479433016964	metal binding site [ion binding]; metal-binding site
479433016965	putative dimer interface [polypeptide binding]; other site
479433016966	Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144
479433016967	ATP-grasp domain; Region: ATP-grasp_4; cl17255
479433016968	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
479433016969	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
479433016970	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
479433016971	inhibitor-cofactor binding pocket; inhibition site
479433016972	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433016973	catalytic residue [active]
479433016974	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
479433016975	TPP-binding site [chemical binding]; other site
479433016976	dimer interface [polypeptide binding]; other site
479433016977	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
479433016978	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
479433016979	PYR/PP interface [polypeptide binding]; other site
479433016980	dimer interface [polypeptide binding]; other site
479433016981	TPP binding site [chemical binding]; other site
479433016982	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
479433016983	lysine biosynthesis protein LysW; Region: lysW; TIGR01206
479433016984	Biofilm formation and stress response factor; Region: BsmA; pfam10014
479433016985	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
479433016986	classical (c) SDRs; Region: SDR_c; cd05233
479433016987	NAD(P) binding site [chemical binding]; other site
479433016988	active site
479433016989	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
479433016990	classical (c) SDRs; Region: SDR_c; cd05233
479433016991	NAD(P) binding site [chemical binding]; other site
479433016992	active site
479433016993	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
479433016994	Fatty acid desaturase; Region: FA_desaturase; pfam00487
479433016995	putative di-iron ligands [ion binding]; other site
479433016996	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
479433016997	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
479433016998	Protein of unknown function (DUF1062); Region: DUF1062; cl01786
479433016999	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
479433017000	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
479433017001	acetylglutamate/acetylaminoadipate kinase; Provisional; Region: PRK14058
479433017002	nucleotide binding site [chemical binding]; other site
479433017003	substrate binding site [chemical binding]; other site
479433017004	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
479433017005	ligand-binding site [chemical binding]; other site
479433017006	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
479433017007	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
479433017008	Active Sites [active]
479433017009	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
479433017010	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
479433017011	CysD dimerization site [polypeptide binding]; other site
479433017012	G1 box; other site
479433017013	putative GEF interaction site [polypeptide binding]; other site
479433017014	GTP/Mg2+ binding site [chemical binding]; other site
479433017015	Switch I region; other site
479433017016	G2 box; other site
479433017017	G3 box; other site
479433017018	Switch II region; other site
479433017019	G4 box; other site
479433017020	G5 box; other site
479433017021	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
479433017022	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
479433017023	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433017024	Phosphopantetheine attachment site; Region: PP-binding; cl09936
479433017025	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
479433017026	active site
479433017027	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
479433017028	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
479433017029	substrate binding pocket [chemical binding]; other site
479433017030	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
479433017031	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
479433017032	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
479433017033	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
479433017034	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
479433017035	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
479433017036	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433017037	acyl-activating enzyme (AAE) consensus motif; other site
479433017038	AMP binding site [chemical binding]; other site
479433017039	active site
479433017040	CoA binding site [chemical binding]; other site
479433017041	Cupin domain; Region: Cupin_2; pfam07883
479433017042	Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143
479433017043	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
479433017044	active site
479433017045	nucleotide binding site [chemical binding]; other site
479433017046	HIGH motif; other site
479433017047	KMSKS motif; other site
479433017048	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
479433017049	tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197
479433017050	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
479433017051	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
479433017052	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
479433017053	active site
479433017054	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433017055	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065
479433017056	B12 binding site [chemical binding]; other site
479433017057	Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245
479433017058	substrate binding site [chemical binding]; other site
479433017059	B12 cofactor binding site [chemical binding]; other site
479433017060	heterodimer (sigma-epsilon) interface [polypeptide binding]; other site
479433017061	homodimer (epsilon-epsilon) interface [polypeptide binding]; other site
479433017062	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
479433017063	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
479433017064	substrate binding pocket [chemical binding]; other site
479433017065	membrane-bound complex binding site; other site
479433017066	hinge residues; other site
479433017067	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
479433017068	EamA-like transporter family; Region: EamA; pfam00892
479433017069	EamA-like transporter family; Region: EamA; pfam00892
479433017070	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
479433017071	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
479433017072	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
479433017073	nucleotide binding site [chemical binding]; other site
479433017074	substrate binding site [chemical binding]; other site
479433017075	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
479433017076	substrate binding pocket [chemical binding]; other site
479433017077	active site
479433017078	iron coordination sites [ion binding]; other site
479433017079	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433017080	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433017081	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
479433017082	dimerization interface [polypeptide binding]; other site
479433017083	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
479433017084	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433017085	homodimer interface [polypeptide binding]; other site
479433017086	catalytic residue [active]
479433017087	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
479433017088	FAD binding domain; Region: FAD_binding_4; pfam01565
479433017089	Berberine and berberine like; Region: BBE; pfam08031
479433017090	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
479433017091	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
479433017092	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433017093	homodimer interface [polypeptide binding]; other site
479433017094	catalytic residue [active]
479433017095	Methyltransferase domain; Region: Methyltransf_23; pfam13489
479433017096	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433017097	S-adenosylmethionine binding site [chemical binding]; other site
479433017098	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433017099	FeS/SAM binding site; other site
479433017100	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
479433017101	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
479433017102	AzlC protein; Region: AzlC; cl00570
479433017103	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433017104	MarR family; Region: MarR; pfam01047
479433017105	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
479433017106	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433017107	NAD(P) binding site [chemical binding]; other site
479433017108	active site
479433017109	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
479433017110	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
479433017111	conserved cys residue [active]
479433017112	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433017113	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433017114	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433017115	putative substrate translocation pore; other site
479433017116	Family description; Region: DsbD_2; pfam13386
479433017117	WHG domain; Region: WHG; pfam13305
479433017118	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
479433017119	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
479433017120	active site
479433017121	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
479433017122	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
479433017123	active site
479433017124	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
479433017125	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
479433017126	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
479433017127	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
479433017128	putative NADP binding site [chemical binding]; other site
479433017129	active site
479433017130	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
479433017131	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
479433017132	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
479433017133	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
479433017134	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
479433017135	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
479433017136	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433017137	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
479433017138	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433017139	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
479433017140	RibD C-terminal domain; Region: RibD_C; cl17279
479433017141	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
479433017142	classical (c) SDRs; Region: SDR_c; cd05233
479433017143	NAD(P) binding site [chemical binding]; other site
479433017144	active site
479433017145	Protein of unknown function (DUF1702); Region: DUF1702; pfam08012
479433017146	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
479433017147	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433017148	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433017149	WHG domain; Region: WHG; pfam13305
479433017150	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
479433017151	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433017152	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433017153	WHG domain; Region: WHG; pfam13305
479433017154	TIGR03084 family protein; Region: TIGR03084
479433017155	Wyosine base formation; Region: Wyosine_form; pfam08608
479433017156	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
479433017157	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
479433017158	short chain dehydrogenase; Validated; Region: PRK06182
479433017159	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
479433017160	NADP binding site [chemical binding]; other site
479433017161	active site
479433017162	steroid binding site; other site
479433017163	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
479433017164	active site
479433017165	substrate binding site [chemical binding]; other site
479433017166	ATP binding site [chemical binding]; other site
479433017167	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
479433017168	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
479433017169	ATP-grasp domain; Region: ATP-grasp_4; cl17255
479433017170	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
479433017171	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
479433017172	carboxyltransferase (CT) interaction site; other site
479433017173	biotinylation site [posttranslational modification]; other site
479433017174	Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326
479433017175	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
479433017176	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433017177	NAD(P) binding site [chemical binding]; other site
479433017178	active site
479433017179	Cytochrome P450; Region: p450; cl12078
479433017180	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433017181	Protein of unknown function (DUF1702); Region: DUF1702; pfam08012
479433017182	Protein of unknown function (DUF1702); Region: DUF1702; pfam08012
479433017183	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433017184	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
479433017185	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433017186	TIGR03086 family protein; Region: TIGR03086
479433017187	RNA polymerase factor sigma-70; Validated; Region: PRK08241
479433017188	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433017189	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433017190	DNA binding residues [nucleotide binding]
479433017191	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
479433017192	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
479433017193	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
479433017194	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
479433017195	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
479433017196	TIGR03086 family protein; Region: TIGR03086
479433017197	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
479433017198	SnoaL-like domain; Region: SnoaL_3; pfam13474
479433017199	TIGR03084 family protein; Region: TIGR03084
479433017200	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
479433017201	Protein of unknown function (DUF1702); Region: DUF1702; pfam08012
479433017202	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
479433017203	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
479433017204	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433017205	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
479433017206	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433017207	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
479433017208	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433017209	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
479433017210	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433017211	active site
479433017212	phosphorylation site [posttranslational modification]
479433017213	intermolecular recognition site; other site
479433017214	dimerization interface [polypeptide binding]; other site
479433017215	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
479433017216	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
479433017217	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
479433017218	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
479433017219	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
479433017220	ligand binding site [chemical binding]; other site
479433017221	flexible hinge region; other site
479433017222	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433017223	ATP binding site [chemical binding]; other site
479433017224	Mg2+ binding site [ion binding]; other site
479433017225	G-X-G motif; other site
479433017226	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
479433017227	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
479433017228	putative active site [active]
479433017229	putative metal binding site [ion binding]; other site
479433017230	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
479433017231	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
479433017232	Ligand binding site; other site
479433017233	Putative Catalytic site; other site
479433017234	DXD motif; other site
479433017235	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
479433017236	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
479433017237	Predicted membrane protein (DUF2206); Region: DUF2206; pfam09971
479433017238	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
479433017239	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
479433017240	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
479433017241	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
479433017242	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
479433017243	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
479433017244	active site
479433017245	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
479433017246	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
479433017247	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
479433017248	Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919
479433017249	ATP-grasp domain; Region: ATP-grasp_4; cl17255
479433017250	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
479433017251	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
479433017252	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
479433017253	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
479433017254	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
479433017255	active site
479433017256	Zn binding site [ion binding]; other site
479433017257	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
479433017258	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
479433017259	motif II; other site
479433017260	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
479433017261	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
479433017262	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
479433017263	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
479433017264	methionine sulfoxide reductase A; Provisional; Region: PRK14054
479433017265	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
479433017266	RHS Repeat; Region: RHS_repeat; pfam05593
479433017267	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
479433017268	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
479433017269	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
479433017270	peptidase domain interface [polypeptide binding]; other site
479433017271	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
479433017272	active site
479433017273	catalytic residues [active]
479433017274	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
479433017275	catalytic residues [active]
479433017276	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
479433017277	DNA binding site [nucleotide binding]
479433017278	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433017279	NB-ARC domain; Region: NB-ARC; pfam00931
479433017280	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433017281	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
479433017282	TPR motif; other site
479433017283	binding surface
479433017284	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433017285	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433017286	YWTD domain; Region: YWTD; cl17223
479433017287	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433017288	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433017289	short chain dehydrogenase; Provisional; Region: PRK08251
479433017290	classical (c) SDRs; Region: SDR_c; cd05233
479433017291	NAD(P) binding site [chemical binding]; other site
479433017292	active site
479433017293	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
479433017294	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
479433017295	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
479433017296	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
479433017297	1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292
479433017298	TPP-binding site [chemical binding]; other site
479433017299	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
479433017300	PYR/PP interface [polypeptide binding]; other site
479433017301	dimer interface [polypeptide binding]; other site
479433017302	TPP binding site [chemical binding]; other site
479433017303	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
479433017304	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
479433017305	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
479433017306	Walker A/P-loop; other site
479433017307	ATP binding site [chemical binding]; other site
479433017308	Q-loop/lid; other site
479433017309	ABC transporter signature motif; other site
479433017310	Walker B; other site
479433017311	D-loop; other site
479433017312	H-loop/switch region; other site
479433017313	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
479433017314	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
479433017315	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
479433017316	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
479433017317	homodimer interface [polypeptide binding]; other site
479433017318	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433017319	catalytic residue [active]
479433017320	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
479433017321	Predicted membrane protein [Function unknown]; Region: COG2119
479433017322	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
479433017323	U2 snRNP auxilliary factor, large subunit, splicing factor; Region: U2AF_lg; TIGR01642
479433017324	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
479433017325	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
479433017326	nudix motif; other site
479433017327	Ferritin-like domain; Region: Ferritin; pfam00210
479433017328	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
479433017329	dinuclear metal binding motif [ion binding]; other site
479433017330	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
479433017331	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
479433017332	nucleotide binding site [chemical binding]; other site
479433017333	NEF interaction site [polypeptide binding]; other site
479433017334	SBD interface [polypeptide binding]; other site
479433017335	heat shock protein GrpE; Provisional; Region: PRK14140
479433017336	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
479433017337	dimer interface [polypeptide binding]; other site
479433017338	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
479433017339	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
479433017340	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
479433017341	HSP70 interaction site [polypeptide binding]; other site
479433017342	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
479433017343	substrate binding site [polypeptide binding]; other site
479433017344	dimer interface [polypeptide binding]; other site
479433017345	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
479433017346	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
479433017347	Clp amino terminal domain; Region: Clp_N; pfam02861
479433017348	Clp amino terminal domain; Region: Clp_N; pfam02861
479433017349	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433017350	Walker A motif; other site
479433017351	ATP binding site [chemical binding]; other site
479433017352	Walker B motif; other site
479433017353	arginine finger; other site
479433017354	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433017355	Walker A motif; other site
479433017356	ATP binding site [chemical binding]; other site
479433017357	Walker B motif; other site
479433017358	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
479433017359	thioredoxin 2; Provisional; Region: PRK10996
479433017360	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
479433017361	catalytic residues [active]
479433017362	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
479433017363	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
479433017364	ligand binding site [chemical binding]; other site
479433017365	flexible hinge region; other site
479433017366	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
479433017367	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
479433017368	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
479433017369	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
479433017370	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
479433017371	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
479433017372	Cl- selectivity filter; other site
479433017373	Cl- binding residues [ion binding]; other site
479433017374	pore gating glutamate residue; other site
479433017375	dimer interface [polypeptide binding]; other site
479433017376	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
479433017377	FOG: CBS domain [General function prediction only]; Region: COG0517
479433017378	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433017379	MarR family; Region: MarR; pfam01047
479433017380	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433017381	MarR family; Region: MarR_2; pfam12802
479433017382	MarR family; Region: MarR_2; cl17246
479433017383	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
479433017384	Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358
479433017385	putative ligand binding site [chemical binding]; other site
479433017386	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
479433017387	Na binding site [ion binding]; other site
479433017388	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
479433017389	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
479433017390	alpha-gamma subunit interface [polypeptide binding]; other site
479433017391	beta-gamma subunit interface [polypeptide binding]; other site
479433017392	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
479433017393	gamma-beta subunit interface [polypeptide binding]; other site
479433017394	alpha-beta subunit interface [polypeptide binding]; other site
479433017395	urease subunit alpha; Reviewed; Region: ureC; PRK13206
479433017396	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
479433017397	subunit interactions [polypeptide binding]; other site
479433017398	active site
479433017399	flap region; other site
479433017400	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
479433017401	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
479433017402	UreD urease accessory protein; Region: UreD; cl00530
479433017403	Isochorismatase family; Region: Isochorismatase; pfam00857
479433017404	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
479433017405	catalytic triad [active]
479433017406	conserved cis-peptide bond; other site
479433017407	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
479433017408	Sulfate transporter family; Region: Sulfate_transp; pfam00916
479433017409	Transcriptional regulators [Transcription]; Region: FadR; COG2186
479433017410	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433017411	DNA-binding site [nucleotide binding]; DNA binding site
479433017412	FCD domain; Region: FCD; pfam07729
479433017413	Isochorismatase family; Region: Isochorismatase; pfam00857
479433017414	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
479433017415	catalytic triad [active]
479433017416	conserved cis-peptide bond; other site
479433017417	Cupin domain; Region: Cupin_2; cl17218
479433017418	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
479433017419	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
479433017420	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433017421	Avidin family; Region: Avidin; pfam01382
479433017422	His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978
479433017423	Amidohydrolase; Region: Amidohydro_2; pfam04909
479433017424	active site
479433017425	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
479433017426	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
479433017427	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
479433017428	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
479433017429	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
479433017430	FAD binding domain; Region: FAD_binding_3; pfam01494
479433017431	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
479433017432	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
479433017433	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
479433017434	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
479433017435	catalytic Zn binding site [ion binding]; other site
479433017436	NAD binding site [chemical binding]; other site
479433017437	structural Zn binding site [ion binding]; other site
479433017438	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
479433017439	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
479433017440	NAD(P) binding site [chemical binding]; other site
479433017441	catalytic residues [active]
479433017442	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
479433017443	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
479433017444	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433017445	The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6,  and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348
479433017446	putative active site [active]
479433017447	putative metal binding site [ion binding]; other site
479433017448	Transcriptional regulator [Transcription]; Region: IclR; COG1414
479433017449	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
479433017450	Bacterial transcriptional regulator; Region: IclR; pfam01614
479433017451	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433017452	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433017453	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433017454	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
479433017455	haloalkane dehalogenase; Provisional; Region: PRK03592
479433017456	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
479433017457	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
479433017458	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433017459	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433017460	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
479433017461	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433017462	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433017463	DNA binding residues [nucleotide binding]
479433017464	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
479433017465	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433017466	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433017467	putative sugar binding sites [chemical binding]; other site
479433017468	Q-X-W motif; other site
479433017469	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433017470	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433017471	putative sugar binding sites [chemical binding]; other site
479433017472	Q-X-W motif; other site
479433017473	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820
479433017474	putative sugar binding sites [chemical binding]; other site
479433017475	Q-X-W motif; other site
479433017476	Class I aldolases; Region: Aldolase_Class_I; cl17187
479433017477	catalytic residue [active]
479433017478	PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023
479433017479	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
479433017480	NmrA-like family; Region: NmrA; pfam05368
479433017481	NADP binding site [chemical binding]; other site
479433017482	active site
479433017483	regulatory binding site [polypeptide binding]; other site
479433017484	PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023
479433017485	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
479433017486	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
479433017487	dimer interface [polypeptide binding]; other site
479433017488	active site
479433017489	Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein; Region: CLF; cd00832
479433017490	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
479433017491	active site
479433017492	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433017493	N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus  OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861
479433017494	putative hydrophobic ligand binding site [chemical binding]; other site
479433017495	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
479433017496	hydrophobic ligand binding site; other site
479433017497	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433017498	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433017499	active site
479433017500	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
479433017501	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433017502	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
479433017503	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
479433017504	classical (c) SDRs; Region: SDR_c; cd05233
479433017505	NAD(P) binding site [chemical binding]; other site
479433017506	active site
479433017507	Polyketide ketoreductase, classical (c) SDR; Region: PKR_SDR_c; cd08945
479433017508	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
479433017509	NAD(P) binding site [chemical binding]; other site
479433017510	homodimer interface [polypeptide binding]; other site
479433017511	substrate binding site [chemical binding]; other site
479433017512	active site
479433017513	SnoaL-like domain; Region: SnoaL_4; pfam13577
479433017514	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
479433017515	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433017516	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
479433017517	putative NAD(P) binding site [chemical binding]; other site
479433017518	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433017519	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433017520	putative substrate translocation pore; other site
479433017521	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433017522	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
479433017523	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
479433017524	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
479433017525	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
479433017526	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
479433017527	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
479433017528	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
479433017529	carboxyltransferase (CT) interaction site; other site
479433017530	biotinylation site [posttranslational modification]; other site
479433017531	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
479433017532	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
479433017533	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
479433017534	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433017535	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
479433017536	active site
479433017537	Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081
479433017538	Ca binding site [ion binding]; other site
479433017539	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433017540	DNA-binding site [nucleotide binding]; DNA binding site
479433017541	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
479433017542	UTRA domain; Region: UTRA; pfam07702
479433017543	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
479433017544	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433017545	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
479433017546	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
479433017547	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
479433017548	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433017549	putative NAD(P) binding site [chemical binding]; other site
479433017550	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433017551	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
479433017552	helicase superfamily c-terminal domain; Region: HELICc; smart00490
479433017553	Helicase associated domain (HA2); Region: HA2; cl04503
479433017554	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
479433017555	radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269
479433017556	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433017557	FeS/SAM binding site; other site
479433017558	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433017559	AAA ATPase domain; Region: AAA_16; pfam13191
479433017560	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433017561	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433017562	binding surface
479433017563	TPR motif; other site
479433017564	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433017565	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433017566	NADH(P)-binding; Region: NAD_binding_10; pfam13460
479433017567	NAD(P) binding site [chemical binding]; other site
479433017568	active site
479433017569	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
479433017570	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433017571	NAD(P) binding site [chemical binding]; other site
479433017572	active site
479433017573	Hemerythrin-like domain; Region: Hr-like; cd12108
479433017574	Fe binding site [ion binding]; other site
479433017575	MarR family; Region: MarR_2; pfam12802
479433017576	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
479433017577	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
479433017578	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
479433017579	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
479433017580	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433017581	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433017582	Walker A/P-loop; other site
479433017583	ATP binding site [chemical binding]; other site
479433017584	Q-loop/lid; other site
479433017585	ABC transporter signature motif; other site
479433017586	Walker B; other site
479433017587	D-loop; other site
479433017588	H-loop/switch region; other site
479433017589	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433017590	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433017591	active site
479433017592	phosphorylation site [posttranslational modification]
479433017593	intermolecular recognition site; other site
479433017594	dimerization interface [polypeptide binding]; other site
479433017595	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433017596	DNA binding residues [nucleotide binding]
479433017597	dimerization interface [polypeptide binding]; other site
479433017598	Histidine kinase; Region: HisKA_3; pfam07730
479433017599	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433017600	ATP binding site [chemical binding]; other site
479433017601	Mg2+ binding site [ion binding]; other site
479433017602	G-X-G motif; other site
479433017603	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
479433017604	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433017605	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
479433017606	Walker A/P-loop; other site
479433017607	ATP binding site [chemical binding]; other site
479433017608	Q-loop/lid; other site
479433017609	ABC transporter signature motif; other site
479433017610	Walker B; other site
479433017611	D-loop; other site
479433017612	H-loop/switch region; other site
479433017613	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
479433017614	NADH(P)-binding; Region: NAD_binding_10; pfam13460
479433017615	NAD binding site [chemical binding]; other site
479433017616	substrate binding site [chemical binding]; other site
479433017617	putative active site [active]
479433017618	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
479433017619	Domain of unknown function DUF20; Region: UPF0118; pfam01594
479433017620	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433017621	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433017622	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
479433017623	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433017624	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
479433017625	NAD(P) binding site [chemical binding]; other site
479433017626	active site
479433017627	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433017628	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
479433017629	putative hydrophobic ligand binding site [chemical binding]; other site
479433017630	Hemerythrin-like domain; Region: Hr-like; cd12108
479433017631	Fe binding site [ion binding]; other site
479433017632	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433017633	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
479433017634	anti sigma factor interaction site; other site
479433017635	regulatory phosphorylation site [posttranslational modification]; other site
479433017636	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
479433017637	active site
479433017638	Protein of unknown function (DUF4235); Region: DUF4235; pfam14019
479433017639	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
479433017640	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
479433017641	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
479433017642	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433017643	Coenzyme A binding pocket [chemical binding]; other site
479433017644	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433017645	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433017646	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433017647	DNA binding residues [nucleotide binding]
479433017648	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
479433017649	Cellulose binding domain; Region: CBM_2; pfam00553
479433017650	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
479433017651	putative catalytic site [active]
479433017652	putative metal binding site [ion binding]; other site
479433017653	putative phosphate binding site [ion binding]; other site
479433017654	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
479433017655	MMPL family; Region: MMPL; pfam03176
479433017656	MMPL family; Region: MMPL; pfam03176
479433017657	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433017658	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433017659	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
479433017660	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433017661	NAD(P) binding site [chemical binding]; other site
479433017662	active site
479433017663	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
479433017664	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
479433017665	Walker A/P-loop; other site
479433017666	ATP binding site [chemical binding]; other site
479433017667	Q-loop/lid; other site
479433017668	ABC transporter signature motif; other site
479433017669	Walker B; other site
479433017670	D-loop; other site
479433017671	H-loop/switch region; other site
479433017672	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
479433017673	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433017674	Walker A/P-loop; other site
479433017675	ATP binding site [chemical binding]; other site
479433017676	Q-loop/lid; other site
479433017677	ABC transporter signature motif; other site
479433017678	Walker B; other site
479433017679	D-loop; other site
479433017680	H-loop/switch region; other site
479433017681	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
479433017682	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
479433017683	FtsX-like permease family; Region: FtsX; pfam02687
479433017684	Right handed beta helix region; Region: Beta_helix; pfam13229
479433017685	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
479433017686	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433017687	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433017688	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433017689	CHAT domain; Region: CHAT; pfam12770
479433017690	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
479433017691	G1 box; other site
479433017692	GTP/Mg2+ binding site [chemical binding]; other site
479433017693	G2 box; other site
479433017694	Switch I region; other site
479433017695	G3 box; other site
479433017696	Switch II region; other site
479433017697	G4 box; other site
479433017698	G5 box; other site
479433017699	Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861
479433017700	Bacterial transcriptional activator domain; Region: BTAD; smart01043
479433017701	CHAT domain; Region: CHAT; pfam12770
479433017702	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
479433017703	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433017704	acyl-CoA synthetase; Validated; Region: PRK06188
479433017705	acyl-activating enzyme (AAE) consensus motif; other site
479433017706	AMP binding site [chemical binding]; other site
479433017707	active site
479433017708	CoA binding site [chemical binding]; other site
479433017709	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
479433017710	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
479433017711	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
479433017712	putative active site [active]
479433017713	putative dimer interface [polypeptide binding]; other site
479433017714	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
479433017715	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
479433017716	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
479433017717	high affinity sulphate transporter 1; Region: sulP; TIGR00815
479433017718	Sulfate transporter family; Region: Sulfate_transp; pfam00916
479433017719	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
479433017720	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
479433017721	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
479433017722	Protein of unknown function (DUF3179); Region: DUF3179; pfam11376
479433017723	Short C-terminal domain; Region: SHOCT; pfam09851
479433017724	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
479433017725	Short C-terminal domain; Region: SHOCT; pfam09851
479433017726	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
479433017727	hypothetical protein; Provisional; Region: PRK07907
479433017728	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
479433017729	active site
479433017730	metal binding site [ion binding]; metal-binding site
479433017731	dimer interface [polypeptide binding]; other site
479433017732	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
479433017733	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
479433017734	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
479433017735	active site
479433017736	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433017737	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433017738	putative substrate translocation pore; other site
479433017739	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
479433017740	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
479433017741	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433017742	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433017743	putative substrate translocation pore; other site
479433017744	TIGR03118 family protein; Region: PEPCTERM_chp_1
479433017745	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
479433017746	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
479433017747	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
479433017748	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
479433017749	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
479433017750	NAD binding site [chemical binding]; other site
479433017751	catalytic Zn binding site [ion binding]; other site
479433017752	structural Zn binding site [ion binding]; other site
479433017753	Protein of unknown function DUF72; Region: DUF72; pfam01904
479433017754	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
479433017755	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
479433017756	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
479433017757	CGNR zinc finger; Region: zf-CGNR; pfam11706
479433017758	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433017759	non-specific DNA binding site [nucleotide binding]; other site
479433017760	salt bridge; other site
479433017761	sequence-specific DNA binding site [nucleotide binding]; other site
479433017762	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
479433017763	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
479433017764	Protein of unknown function (DUF2690); Region: DUF2690; pfam10901
479433017765	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433017766	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433017767	putative sugar binding sites [chemical binding]; other site
479433017768	Q-X-W motif; other site
479433017769	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
479433017770	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
479433017771	active site
479433017772	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433017773	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433017774	putative sugar binding sites [chemical binding]; other site
479433017775	Q-X-W motif; other site
479433017776	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433017777	putative sugar binding sites [chemical binding]; other site
479433017778	Q-X-W motif; other site
479433017779	Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308
479433017780	Right handed beta helix region; Region: Beta_helix; pfam13229
479433017781	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
479433017782	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
479433017783	intracellular protease, PfpI family; Region: PfpI; TIGR01382
479433017784	proposed catalytic triad [active]
479433017785	conserved cys residue [active]
479433017786	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433017787	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433017788	ATP binding site [chemical binding]; other site
479433017789	Mg2+ binding site [ion binding]; other site
479433017790	G-X-G motif; other site
479433017791	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
479433017792	anti sigma factor interaction site; other site
479433017793	regulatory phosphorylation site [posttranslational modification]; other site
479433017794	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
479433017795	Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028
479433017796	active site
479433017797	DNA binding site [nucleotide binding]
479433017798	Int/Topo IB signature motif; other site
479433017799	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
479433017800	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
479433017801	CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704
479433017802	putative methyltransferase; Provisional; Region: PRK14967
479433017803	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433017804	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
479433017805	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
479433017806	Interdomain contacts; other site
479433017807	Cytokine receptor motif; other site
479433017808	Cellulose binding domain; Region: CBM_2; pfam00553
479433017809	Bulb-type mannose-specific lectin; Region: B_lectin; smart00108
479433017810	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
479433017811	dimerization interface [polypeptide binding]; other site
479433017812	mannose binding site [chemical binding]; other site
479433017813	Epoxide hydrolase N terminus; Region: EHN; pfam06441
479433017814	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433017815	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433017816	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433017817	dimerization interface [polypeptide binding]; other site
479433017818	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433017819	dimer interface [polypeptide binding]; other site
479433017820	phosphorylation site [posttranslational modification]
479433017821	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433017822	ATP binding site [chemical binding]; other site
479433017823	Mg2+ binding site [ion binding]; other site
479433017824	G-X-G motif; other site
479433017825	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433017826	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433017827	active site
479433017828	phosphorylation site [posttranslational modification]
479433017829	intermolecular recognition site; other site
479433017830	dimerization interface [polypeptide binding]; other site
479433017831	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433017832	DNA binding site [nucleotide binding]
479433017833	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
479433017834	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
479433017835	Active site serine [active]
479433017836	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433017837	sugar binding site [chemical binding]; other site
479433017838	Fn3 associated; Region: Fn3_assoc; pfam13287
479433017839	Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182
479433017840	active site
479433017841	catalytic residues [active]
479433017842	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
479433017843	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433017844	sugar binding site [chemical binding]; other site
479433017845	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433017846	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433017847	DNA binding site [nucleotide binding]
479433017848	domain linker motif; other site
479433017849	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433017850	ligand binding site [chemical binding]; other site
479433017851	dimerization interface [polypeptide binding]; other site
479433017852	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
479433017853	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
479433017854	putative DNA binding site [nucleotide binding]; other site
479433017855	putative Zn2+ binding site [ion binding]; other site
479433017856	AsnC family; Region: AsnC_trans_reg; pfam01037
479433017857	putative transporter; Provisional; Region: PRK11021
479433017858	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433017859	putative substrate translocation pore; other site
479433017860	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
479433017861	NB-ARC domain; Region: NB-ARC; pfam00931
479433017862	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433017863	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433017864	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433017865	binding surface
479433017866	TPR motif; other site
479433017867	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433017868	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
479433017869	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
479433017870	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433017871	FeS/SAM binding site; other site
479433017872	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
479433017873	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
479433017874	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
479433017875	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
479433017876	Active site cavity [active]
479433017877	catalytic acid [active]
479433017878	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
479433017879	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
479433017880	substrate binding pocket [chemical binding]; other site
479433017881	chain length determination region; other site
479433017882	substrate-Mg2+ binding site; other site
479433017883	catalytic residues [active]
479433017884	aspartate-rich region 1; other site
479433017885	active site lid residues [active]
479433017886	aspartate-rich region 2; other site
479433017887	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
479433017888	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
479433017889	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
479433017890	active site lid residues [active]
479433017891	substrate binding pocket [chemical binding]; other site
479433017892	catalytic residues [active]
479433017893	substrate-Mg2+ binding site; other site
479433017894	aspartate-rich region 1; other site
479433017895	aspartate-rich region 2; other site
479433017896	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
479433017897	active site lid residues [active]
479433017898	substrate binding pocket [chemical binding]; other site
479433017899	catalytic residues [active]
479433017900	substrate-Mg2+ binding site; other site
479433017901	aspartate-rich region 1; other site
479433017902	aspartate-rich region 2; other site
479433017903	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
479433017904	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
479433017905	NodB motif; other site
479433017906	putative active site [active]
479433017907	putative catalytic site [active]
479433017908	putative Zn binding site [ion binding]; other site
479433017909	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
479433017910	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
479433017911	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
479433017912	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433017913	NAD(P) binding site [chemical binding]; other site
479433017914	active site
479433017915	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
479433017916	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
479433017917	inhibitor-cofactor binding pocket; inhibition site
479433017918	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433017919	catalytic residue [active]
479433017920	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
479433017921	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
479433017922	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433017923	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433017924	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433017925	DNA binding residues [nucleotide binding]
479433017926	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
479433017927	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433017928	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433017929	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433017930	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433017931	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433017932	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433017933	active site
479433017934	catalytic tetrad [active]
479433017935	Cellulose binding domain; Region: CBM_2; pfam00553
479433017936	Cellulose binding domain; Region: CBM_2; pfam00553
479433017937	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
479433017938	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433017939	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433017940	DNA binding site [nucleotide binding]
479433017941	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
479433017942	putative ligand binding site [chemical binding]; other site
479433017943	putative dimerization interface [polypeptide binding]; other site
479433017944	Cellulose binding domain; Region: CBM_2; pfam00553
479433017945	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
479433017946	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
479433017947	D-xylulose kinase; Region: XylB; TIGR01312
479433017948	nucleotide binding site [chemical binding]; other site
479433017949	xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631
479433017950	xylose isomerase; Provisional; Region: PRK12677
479433017951	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433017952	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
479433017953	Domain of unknown function (DUF3817); Region: DUF3817; cl14844
479433017954	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
479433017955	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
479433017956	conserved cys residue [active]
479433017957	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433017958	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433017959	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
479433017960	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
479433017961	putative ligand binding site [chemical binding]; other site
479433017962	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
479433017963	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
479433017964	Walker A/P-loop; other site
479433017965	ATP binding site [chemical binding]; other site
479433017966	Q-loop/lid; other site
479433017967	ABC transporter signature motif; other site
479433017968	Walker B; other site
479433017969	D-loop; other site
479433017970	H-loop/switch region; other site
479433017971	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
479433017972	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
479433017973	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
479433017974	TM-ABC transporter signature motif; other site
479433017975	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
479433017976	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
479433017977	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
479433017978	dimer interface [polypeptide binding]; other site
479433017979	ADP-ribose binding site [chemical binding]; other site
479433017980	active site
479433017981	nudix motif; other site
479433017982	metal binding site [ion binding]; metal-binding site
479433017983	TIR domain; Region: TIR_2; pfam13676
479433017984	CHAT domain; Region: CHAT; pfam12770
479433017985	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
479433017986	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433017987	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433017988	active site
479433017989	phosphorylation site [posttranslational modification]
479433017990	intermolecular recognition site; other site
479433017991	dimerization interface [polypeptide binding]; other site
479433017992	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433017993	dimerization interface [polypeptide binding]; other site
479433017994	DNA binding residues [nucleotide binding]
479433017995	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433017996	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433017997	active site
479433017998	ATP binding site [chemical binding]; other site
479433017999	substrate binding site [chemical binding]; other site
479433018000	activation loop (A-loop); other site
479433018001	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433018002	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433018003	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
479433018004	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
479433018005	phosphopeptide binding site; other site
479433018006	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
479433018007	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
479433018008	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
479433018009	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433018010	Histidine kinase; Region: HisKA_3; pfam07730
479433018011	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433018012	ATP binding site [chemical binding]; other site
479433018013	Mg2+ binding site [ion binding]; other site
479433018014	G-X-G motif; other site
479433018015	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
479433018016	N- and C-terminal domain interface [polypeptide binding]; other site
479433018017	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
479433018018	active site
479433018019	putative catalytic site [active]
479433018020	metal binding site [ion binding]; metal-binding site
479433018021	ATP binding site [chemical binding]; other site
479433018022	carbohydrate binding site [chemical binding]; other site
479433018023	short chain dehydrogenase; Validated; Region: PRK08324
479433018024	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
479433018025	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433018026	NAD(P) binding site [chemical binding]; other site
479433018027	active site
479433018028	L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629
479433018029	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
479433018030	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433018031	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433018032	DNA binding site [nucleotide binding]
479433018033	domain linker motif; other site
479433018034	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433018035	dimerization interface [polypeptide binding]; other site
479433018036	ligand binding site [chemical binding]; other site
479433018037	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
479433018038	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
479433018039	substrate binding site [chemical binding]; other site
479433018040	ATP binding site [chemical binding]; other site
479433018041	short chain dehydrogenase; Provisional; Region: PRK08219
479433018042	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433018043	NAD(P) binding site [chemical binding]; other site
479433018044	active site
479433018045	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433018046	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433018047	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
479433018048	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433018049	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752
479433018050	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433018051	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433018052	DNA binding site [nucleotide binding]
479433018053	domain linker motif; other site
479433018054	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433018055	dimerization interface [polypeptide binding]; other site
479433018056	ligand binding site [chemical binding]; other site
479433018057	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167
479433018058	putative ligand binding site [chemical binding]; other site
479433018059	putative NAD binding site [chemical binding]; other site
479433018060	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
479433018061	catalytic site [active]
479433018062	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
479433018063	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433018064	dimer interface [polypeptide binding]; other site
479433018065	conserved gate region; other site
479433018066	ABC-ATPase subunit interface; other site
479433018067	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433018068	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433018069	dimer interface [polypeptide binding]; other site
479433018070	conserved gate region; other site
479433018071	putative PBP binding loops; other site
479433018072	ABC-ATPase subunit interface; other site
479433018073	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433018074	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942
479433018075	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
479433018076	DCoH tetramer interaction site [polypeptide binding]; other site
479433018077	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
479433018078	substrate binding site [chemical binding]; other site
479433018079	catalytic residues [active]
479433018080	Right handed beta helix region; Region: Beta_helix; pfam13229
479433018081	Domain of unknown function (DUF4265); Region: DUF4265; pfam14085
479433018082	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
479433018083	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433018084	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433018085	dimer interface [polypeptide binding]; other site
479433018086	conserved gate region; other site
479433018087	putative PBP binding loops; other site
479433018088	ABC-ATPase subunit interface; other site
479433018089	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
479433018090	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433018091	putative PBP binding loops; other site
479433018092	dimer interface [polypeptide binding]; other site
479433018093	ABC-ATPase subunit interface; other site
479433018094	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433018095	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433018096	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433018097	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433018098	DNA binding site [nucleotide binding]
479433018099	domain linker motif; other site
479433018100	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
479433018101	ligand binding site [chemical binding]; other site
479433018102	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
479433018103	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
479433018104	structural tetrad; other site
479433018105	FOG: WD40 repeat [General function prediction only]; Region: COG2319
479433018106	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
479433018107	active site
479433018108	catalytic site [active]
479433018109	putative metal binding site [ion binding]; other site
479433018110	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
479433018111	putative active site [active]
479433018112	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433018113	TPR motif; other site
479433018114	binding surface
479433018115	TPR repeat; Region: TPR_11; pfam13414
479433018116	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433018117	binding surface
479433018118	TPR motif; other site
479433018119	Tetratricopeptide repeat; Region: TPR_16; pfam13432
479433018120	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
479433018121	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
479433018122	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
479433018123	active site
479433018124	PHP-associated; Region: PHP_C; pfam13263
479433018125	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433018126	MarR family; Region: MarR; pfam01047
479433018127	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
479433018128	Adenosylhomocysteinase; Provisional; Region: PTZ00075
479433018129	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
479433018130	homotetramer interface [polypeptide binding]; other site
479433018131	ligand binding site [chemical binding]; other site
479433018132	catalytic site [active]
479433018133	NAD binding site [chemical binding]; other site
479433018134	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433018135	Coenzyme A binding pocket [chemical binding]; other site
479433018136	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
479433018137	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
479433018138	Multicopper oxidase; Region: Cu-oxidase; pfam00394
479433018139	diaminopimelate decarboxylase; Region: lysA; TIGR01048
479433018140	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
479433018141	active site
479433018142	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
479433018143	substrate binding site [chemical binding]; other site
479433018144	catalytic residues [active]
479433018145	dimer interface [polypeptide binding]; other site
479433018146	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
479433018147	dimer interface [polypeptide binding]; other site
479433018148	catalytic triad [active]
479433018149	hypothetical protein; Provisional; Region: PRK07906
479433018150	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
479433018151	putative metal binding site [ion binding]; other site
479433018152	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433018153	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
479433018154	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
479433018155	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
479433018156	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
479433018157	catalytic residue [active]
479433018158	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
479433018159	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
479433018160	active site
479433018161	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
479433018162	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
479433018163	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433018164	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433018165	DNA binding residues [nucleotide binding]
479433018166	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433018167	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433018168	putative DNA binding site [nucleotide binding]; other site
479433018169	putative Zn2+ binding site [ion binding]; other site
479433018170	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
479433018171	putative dimerization interface [polypeptide binding]; other site
479433018172	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
479433018173	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
479433018174	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433018175	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
479433018176	NlpC/P60 family; Region: NLPC_P60; pfam00877
479433018177	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
479433018178	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
479433018179	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
479433018180	Walker A/P-loop; other site
479433018181	ATP binding site [chemical binding]; other site
479433018182	Q-loop/lid; other site
479433018183	ABC transporter signature motif; other site
479433018184	Walker B; other site
479433018185	D-loop; other site
479433018186	H-loop/switch region; other site
479433018187	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
479433018188	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
479433018189	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
479433018190	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
479433018191	acyl-activating enzyme (AAE) consensus motif; other site
479433018192	putative AMP binding site [chemical binding]; other site
479433018193	putative active site [active]
479433018194	putative CoA binding site [chemical binding]; other site
479433018195	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433018196	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433018197	active site
479433018198	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
479433018199	G1 box; other site
479433018200	GTP/Mg2+ binding site [chemical binding]; other site
479433018201	G2 box; other site
479433018202	Switch I region; other site
479433018203	G3 box; other site
479433018204	Switch II region; other site
479433018205	G4 box; other site
479433018206	G5 box; other site
479433018207	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
479433018208	substrate binding site [chemical binding]; other site
479433018209	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
479433018210	oxyanion hole (OAH) forming residues; other site
479433018211	trimer interface [polypeptide binding]; other site
479433018212	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
479433018213	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
479433018214	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
479433018215	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
479433018216	dimer interface [polypeptide binding]; other site
479433018217	active site
479433018218	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
479433018219	Predicted transcriptional regulators [Transcription]; Region: COG1733
479433018220	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
479433018221	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
479433018222	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
479433018223	catalytic site [active]
479433018224	putative active site [active]
479433018225	putative substrate binding site [chemical binding]; other site
479433018226	HRDC domain; Region: HRDC; pfam00570
479433018227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433018228	phosphorylation site [posttranslational modification]
479433018229	intermolecular recognition site; other site
479433018230	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433018231	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433018232	DNA binding residues [nucleotide binding]
479433018233	dimerization interface [polypeptide binding]; other site
479433018234	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
479433018235	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
479433018236	substrate binding site [chemical binding]; other site
479433018237	active site
479433018238	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
479433018239	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
479433018240	Chlorite dismutase; Region: Chlor_dismutase; pfam06778
479433018241	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433018242	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433018243	active site
479433018244	phosphorylation site [posttranslational modification]
479433018245	intermolecular recognition site; other site
479433018246	dimerization interface [polypeptide binding]; other site
479433018247	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433018248	DNA binding site [nucleotide binding]
479433018249	K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156
479433018250	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
479433018251	similar to hypothetical protein
479433018252	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
479433018253	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
479433018254	active site
479433018255	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
479433018256	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
479433018257	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
479433018258	Ligand Binding Site [chemical binding]; other site
479433018259	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433018260	dimer interface [polypeptide binding]; other site
479433018261	phosphorylation site [posttranslational modification]
479433018262	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433018263	ATP binding site [chemical binding]; other site
479433018264	Mg2+ binding site [ion binding]; other site
479433018265	G-X-G motif; other site
479433018266	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
479433018267	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433018268	active site
479433018269	phosphorylation site [posttranslational modification]
479433018270	intermolecular recognition site; other site
479433018271	dimerization interface [polypeptide binding]; other site
479433018272	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433018273	DNA binding site [nucleotide binding]
479433018274	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
479433018275	homotrimer interaction site [polypeptide binding]; other site
479433018276	putative active site [active]
479433018277	EDD domain protein, DegV family; Region: DegV; TIGR00762
479433018278	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
479433018279	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433018280	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433018281	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
479433018282	dimerization interface [polypeptide binding]; other site
479433018283	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433018284	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
479433018285	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
479433018286	active site
479433018287	HIGH motif; other site
479433018288	nucleotide binding site [chemical binding]; other site
479433018289	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
479433018290	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
479433018291	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
479433018292	active site
479433018293	KMSKS motif; other site
479433018294	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
479433018295	tRNA binding surface [nucleotide binding]; other site
479433018296	YhhN-like protein; Region: YhhN; pfam07947
479433018297	Uncharacterized conserved protein [Function unknown]; Region: COG2898
479433018298	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
479433018299	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
479433018300	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
479433018301	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
479433018302	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
479433018303	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
479433018304	NAD binding site [chemical binding]; other site
479433018305	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
479433018306	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
479433018307	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
479433018308	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
479433018309	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
479433018310	carboxyltransferase (CT) interaction site; other site
479433018311	biotinylation site [posttranslational modification]; other site
479433018312	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879
479433018313	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
479433018314	dimer interface [polypeptide binding]; other site
479433018315	active site
479433018316	CoA binding pocket [chemical binding]; other site
479433018317	acyl carrier protein; Provisional; Region: acpP; PRK00982
479433018318	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
479433018319	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
479433018320	dimer interface [polypeptide binding]; other site
479433018321	active site
479433018322	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
479433018323	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
479433018324	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
479433018325	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
479433018326	Domain of unknown function (DUF377); Region: DUF377; pfam04041
479433018327	active site
479433018328	Tetratrico peptide repeat; Region: TPR_5; pfam12688
479433018329	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433018330	dimerization interface [polypeptide binding]; other site
479433018331	putative DNA binding site [nucleotide binding]; other site
479433018332	putative Zn2+ binding site [ion binding]; other site
479433018333	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
479433018334	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
479433018335	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433018336	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433018337	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
479433018338	dimerization interface [polypeptide binding]; other site
479433018339	substrate binding pocket [chemical binding]; other site
479433018340	Predicted amidohydrolase [General function prediction only]; Region: COG0388
479433018341	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585
479433018342	putative active site [active]
479433018343	catalytic triad [active]
479433018344	putative dimer interface [polypeptide binding]; other site
479433018345	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
479433018346	WHG domain; Region: WHG; pfam13305
479433018347	MMPL family; Region: MMPL; pfam03176
479433018348	MMPL family; Region: MMPL; pfam03176
479433018349	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166
479433018350	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
479433018351	putative ligand binding site [chemical binding]; other site
479433018352	putative NAD binding site [chemical binding]; other site
479433018353	catalytic site [active]
479433018354	DinB superfamily; Region: DinB_2; pfam12867
479433018355	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
479433018356	active site
479433018357	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
479433018358	Transcriptional regulators [Transcription]; Region: FadR; COG2186
479433018359	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433018360	DNA-binding site [nucleotide binding]; DNA binding site
479433018361	FCD domain; Region: FCD; cl11656
479433018362	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
479433018363	AAA domain; Region: AAA_33; pfam13671
479433018364	ATP-binding site [chemical binding]; other site
479433018365	Gluconate-6-phosphate binding site [chemical binding]; other site
479433018366	GntP family permease; Region: GntP_permease; pfam02447
479433018367	fructuronate transporter; Provisional; Region: PRK10034; cl15264
479433018368	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
479433018369	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
479433018370	active site
479433018371	FMN binding site [chemical binding]; other site
479433018372	substrate binding site [chemical binding]; other site
479433018373	3Fe-4S cluster binding site [ion binding]; other site
479433018374	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
479433018375	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433018376	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433018377	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433018378	salt bridge; other site
479433018379	non-specific DNA binding site [nucleotide binding]; other site
479433018380	sequence-specific DNA binding site [nucleotide binding]; other site
479433018381	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
479433018382	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433018383	NAD(P) binding site [chemical binding]; other site
479433018384	active site
479433018385	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
479433018386	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
479433018387	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
479433018388	homodimer interaction site [polypeptide binding]; other site
479433018389	cofactor binding site; other site
479433018390	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433018391	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
479433018392	NAD(P) binding site [chemical binding]; other site
479433018393	active site
479433018394	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
479433018395	active site
479433018396	catalytic residues [active]
479433018397	DNA binding site [nucleotide binding]
479433018398	Int/Topo IB signature motif; other site
479433018399	Helix-turn-helix domain; Region: HTH_17; pfam12728
479433018400	DNA methylase; Region: N6_N4_Mtase; pfam01555
479433018401	Methyltransferase domain; Region: Methyltransf_26; pfam13659
479433018402	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433018403	Tetratricopeptide repeat; Region: TPR_10; pfam13374
479433018404	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433018405	Tetratricopeptide repeat; Region: TPR_10; pfam13374
479433018406	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433018407	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433018408	Tetratricopeptide repeat; Region: TPR_10; pfam13374
479433018409	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433018410	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433018411	Tetratricopeptide repeat; Region: TPR_10; pfam13374
479433018412	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433018413	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433018414	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433018415	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
479433018416	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
479433018417	PrgI family protein; Region: PrgI; pfam12666
479433018418	Domain of unknown function DUF87; Region: DUF87; pfam01935
479433018419	AAA-like domain; Region: AAA_10; pfam12846
479433018420	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
479433018421	AAA-like domain; Region: AAA_10; pfam12846
479433018422	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
479433018423	Replication-relaxation; Region: Replic_Relax; pfam13814
479433018424	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433018425	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
479433018426	Walker A motif; other site
479433018427	ATP binding site [chemical binding]; other site
479433018428	Walker B motif; other site
479433018429	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
479433018430	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
479433018431	active site
479433018432	catalytic site [active]
479433018433	Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082
479433018434	Ca binding site [ion binding]; other site
479433018435	Ca binding site (active) [ion binding]; other site
479433018436	ligand binding site [chemical binding]; other site
479433018437	Glycosyl hydrolase family 43; Region: GH43_6; cd08985
479433018438	active site
479433018439	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433018440	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433018441	putative sugar binding sites [chemical binding]; other site
479433018442	Q-X-W motif; other site
479433018443	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663
479433018444	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433018445	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433018446	putative sugar binding sites [chemical binding]; other site
479433018447	Q-X-W motif; other site
479433018448	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
479433018449	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
479433018450	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
479433018451	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
479433018452	hypothetical protein; Provisional; Region: PRK11622
479433018453	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
479433018454	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433018455	Walker A/P-loop; other site
479433018456	ATP binding site [chemical binding]; other site
479433018457	Q-loop/lid; other site
479433018458	ABC transporter signature motif; other site
479433018459	Walker B; other site
479433018460	D-loop; other site
479433018461	H-loop/switch region; other site
479433018462	TOBE domain; Region: TOBE_2; pfam08402
479433018463	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
479433018464	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433018465	dimer interface [polypeptide binding]; other site
479433018466	conserved gate region; other site
479433018467	putative PBP binding loops; other site
479433018468	ABC-ATPase subunit interface; other site
479433018469	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
479433018470	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433018471	dimer interface [polypeptide binding]; other site
479433018472	conserved gate region; other site
479433018473	putative PBP binding loops; other site
479433018474	ABC-ATPase subunit interface; other site
479433018475	alpha-galactosidase; Region: PLN02808; cl17638
479433018476	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433018477	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433018478	putative sugar binding sites [chemical binding]; other site
479433018479	Q-X-W motif; other site
479433018480	alpha-galactosidase; Region: PLN02808; cl17638
479433018481	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
479433018482	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820
479433018483	Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200
479433018484	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
479433018485	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
479433018486	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
479433018487	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
479433018488	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
479433018489	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433018490	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433018491	putative sugar binding sites [chemical binding]; other site
479433018492	Q-X-W motif; other site
479433018493	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433018494	S-adenosylmethionine binding site [chemical binding]; other site
479433018495	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
479433018496	Ligand Binding Site [chemical binding]; other site
479433018497	Molecular Tunnel; other site
479433018498	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433018499	non-specific DNA binding site [nucleotide binding]; other site
479433018500	salt bridge; other site
479433018501	sequence-specific DNA binding site [nucleotide binding]; other site
479433018502	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
479433018503	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
479433018504	motif II; other site
479433018505	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
479433018506	Bacterial transcriptional activator domain; Region: BTAD; smart01043
479433018507	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
479433018508	Type II/IV secretion system protein; Region: T2SE; pfam00437
479433018509	Walker A motif; other site
479433018510	ATP binding site [chemical binding]; other site
479433018511	Walker B motif; other site
479433018512	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
479433018513	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
479433018514	putative active site [active]
479433018515	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433018516	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433018517	active site
479433018518	catalytic tetrad [active]
479433018519	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433018520	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433018521	dimer interface [polypeptide binding]; other site
479433018522	conserved gate region; other site
479433018523	putative PBP binding loops; other site
479433018524	ABC-ATPase subunit interface; other site
479433018525	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
479433018526	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433018527	dimer interface [polypeptide binding]; other site
479433018528	conserved gate region; other site
479433018529	putative PBP binding loops; other site
479433018530	ABC-ATPase subunit interface; other site
479433018531	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
479433018532	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433018533	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433018534	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433018535	DNA binding site [nucleotide binding]
479433018536	domain linker motif; other site
479433018537	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
479433018538	dimerization interface [polypeptide binding]; other site
479433018539	ligand binding site [chemical binding]; other site
479433018540	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
479433018541	active site
479433018542	catalytic residues [active]
479433018543	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
479433018544	putative metal binding site [ion binding]; other site
479433018545	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
479433018546	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
479433018547	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433018548	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433018549	putative sugar binding sites [chemical binding]; other site
479433018550	Q-X-W motif; other site
479433018551	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433018552	AAA domain; Region: AAA_21; pfam13304
479433018553	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
479433018554	putative active site [active]
479433018555	putative metal-binding site [ion binding]; other site
479433018556	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433018557	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433018558	non-specific DNA binding site [nucleotide binding]; other site
479433018559	salt bridge; other site
479433018560	sequence-specific DNA binding site [nucleotide binding]; other site
479433018561	AAA ATPase domain; Region: AAA_16; pfam13191
479433018562	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
479433018563	structural tetrad; other site
479433018564	FOG: WD40 repeat [General function prediction only]; Region: COG2319
479433018565	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
479433018566	structural tetrad; other site
479433018567	FOG: WD40 repeat [General function prediction only]; Region: COG2319
479433018568	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
479433018569	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
479433018570	Ligand binding site; other site
479433018571	Putative Catalytic site; other site
479433018572	DXD motif; other site
479433018573	PGAP1-like protein; Region: PGAP1; pfam07819
479433018574	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
479433018575	putative active site [active]
479433018576	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
479433018577	active site
479433018578	NTP binding site [chemical binding]; other site
479433018579	metal binding triad [ion binding]; metal-binding site
479433018580	HORMA domain; Region: HORMA; pfam02301
479433018581	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
479433018582	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433018583	Walker B motif; other site
479433018584	arginine finger; other site
479433018585	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433018586	non-specific DNA binding site [nucleotide binding]; other site
479433018587	salt bridge; other site
479433018588	sequence-specific DNA binding site [nucleotide binding]; other site
479433018589	Domain of unknown function (DUF955); Region: DUF955; pfam06114
479433018590	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
479433018591	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
479433018592	gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521
479433018593	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
479433018594	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
479433018595	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
479433018596	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433018597	Walker A/P-loop; other site
479433018598	ATP binding site [chemical binding]; other site
479433018599	Q-loop/lid; other site
479433018600	ABC transporter signature motif; other site
479433018601	Walker B; other site
479433018602	D-loop; other site
479433018603	ABC-2 type transporter; Region: ABC2_membrane; cl17235
479433018604	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
479433018605	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
479433018606	ligand binding site [chemical binding]; other site
479433018607	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
479433018608	active site
479433018609	nucleophile elbow; other site
479433018610	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433018611	active site
479433018612	ATP binding site [chemical binding]; other site
479433018613	substrate binding site [chemical binding]; other site
479433018614	activation loop (A-loop); other site
479433018615	CHAT domain; Region: CHAT; pfam12770
479433018616	Caspase domain; Region: Peptidase_C14; pfam00656
479433018617	AAA ATPase domain; Region: AAA_16; pfam13191
479433018618	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433018619	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433018620	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433018621	DNA binding residues [nucleotide binding]
479433018622	dimerization interface [polypeptide binding]; other site
479433018623	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
479433018624	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433018625	FeS/SAM binding site; other site
479433018626	SUKH-4 immunity protein; Region: SUKH-4; pfam14435
479433018627	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
479433018628	RHS Repeat; Region: RHS_repeat; cl11982
479433018629	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
479433018630	RHS Repeat; Region: RHS_repeat; pfam05593
479433018631	RHS Repeat; Region: RHS_repeat; cl11982
479433018632	RHS Repeat; Region: RHS_repeat; pfam05593
479433018633	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
479433018634	Xanthomonas XOO_2897-like deaminase; Region: XOO_2897-deam; pfam14440
479433018635	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
479433018636	AAA domain; Region: AAA_12; pfam13087
479433018637	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
479433018638	Domain of unknown function (DUF4357); Region: DUF4357; pfam14267
479433018639	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433018640	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
479433018641	Walker A motif; other site
479433018642	ATP binding site [chemical binding]; other site
479433018643	Walker B motif; other site
479433018644	arginine finger; other site
479433018645	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433018646	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433018647	active site
479433018648	phosphorylation site [posttranslational modification]
479433018649	intermolecular recognition site; other site
479433018650	dimerization interface [polypeptide binding]; other site
479433018651	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433018652	DNA binding residues [nucleotide binding]
479433018653	dimerization interface [polypeptide binding]; other site
479433018654	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433018655	Histidine kinase; Region: HisKA_3; pfam07730
479433018656	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433018657	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
479433018658	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
479433018659	Walker A/P-loop; other site
479433018660	ATP binding site [chemical binding]; other site
479433018661	Q-loop/lid; other site
479433018662	ABC transporter signature motif; other site
479433018663	Walker B; other site
479433018664	D-loop; other site
479433018665	H-loop/switch region; other site
479433018666	FtsX-like permease family; Region: FtsX; pfam02687
479433018667	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
479433018668	FtsX-like permease family; Region: FtsX; pfam02687
479433018669	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433018670	putative DNA binding site [nucleotide binding]; other site
479433018671	putative Zn2+ binding site [ion binding]; other site
479433018672	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433018673	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
479433018674	nucleotide binding site [chemical binding]; other site
479433018675	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
479433018676	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
479433018677	active site
479433018678	catalytic site [active]
479433018679	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433018680	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433018681	dimer interface [polypeptide binding]; other site
479433018682	conserved gate region; other site
479433018683	ABC-ATPase subunit interface; other site
479433018684	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
479433018685	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433018686	dimer interface [polypeptide binding]; other site
479433018687	conserved gate region; other site
479433018688	putative PBP binding loops; other site
479433018689	ABC-ATPase subunit interface; other site
479433018690	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433018691	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433018692	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
479433018693	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
479433018694	MG2 domain; Region: A2M_N; pfam01835
479433018695	Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199
479433018696	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
479433018697	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
479433018698	Cellulose binding domain; Region: CBM_2; pfam00553
479433018699	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
479433018700	putative metal binding site [ion binding]; other site
479433018701	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
479433018702	Cellulose binding domain; Region: CBM_2; pfam00553
479433018703	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
479433018704	Domain of unknown function (DUF1793); Region: DUF1793; pfam08760
479433018705	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433018706	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433018707	putative sugar binding sites [chemical binding]; other site
479433018708	Q-X-W motif; other site
479433018709	BNR repeat-like domain; Region: BNR_2; pfam13088
479433018710	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433018711	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433018712	active site
479433018713	phosphorylation site [posttranslational modification]
479433018714	intermolecular recognition site; other site
479433018715	dimerization interface [polypeptide binding]; other site
479433018716	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433018717	DNA binding residues [nucleotide binding]
479433018718	dimerization interface [polypeptide binding]; other site
479433018719	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433018720	Histidine kinase; Region: HisKA_3; pfam07730
479433018721	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433018722	ATP binding site [chemical binding]; other site
479433018723	Mg2+ binding site [ion binding]; other site
479433018724	G-X-G motif; other site
479433018725	MMPL family; Region: MMPL; pfam03176
479433018726	MMPL family; Region: MMPL; pfam03176
479433018727	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433018728	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433018729	active site
479433018730	catalytic tetrad [active]
479433018731	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433018732	salt bridge; other site
479433018733	non-specific DNA binding site [nucleotide binding]; other site
479433018734	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433018735	sequence-specific DNA binding site [nucleotide binding]; other site
479433018736	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
479433018737	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
479433018738	active site
479433018739	SAM binding site [chemical binding]; other site
479433018740	homodimer interface [polypeptide binding]; other site
479433018741	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
479433018742	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
479433018743	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
479433018744	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
479433018745	catalytic site [active]
479433018746	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433018747	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433018748	dimerization interface [polypeptide binding]; other site
479433018749	DNA binding residues [nucleotide binding]
479433018750	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
479433018751	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433018752	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
479433018753	Walker A/P-loop; other site
479433018754	ATP binding site [chemical binding]; other site
479433018755	Q-loop/lid; other site
479433018756	ABC transporter signature motif; other site
479433018757	Walker B; other site
479433018758	D-loop; other site
479433018759	H-loop/switch region; other site
479433018760	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
479433018761	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
479433018762	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
479433018763	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
479433018764	active site
479433018765	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433018766	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
479433018767	NAD(P) binding site [chemical binding]; other site
479433018768	active site
479433018769	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433018770	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433018771	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
479433018772	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
479433018773	active site
479433018774	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
479433018775	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
479433018776	conserved cys residue [active]
479433018777	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433018778	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433018779	NAD(P) binding site [chemical binding]; other site
479433018780	active site
479433018781	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
479433018782	active site
479433018783	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
479433018784	dimer interface [polypeptide binding]; other site
479433018785	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
479433018786	Ligand Binding Site [chemical binding]; other site
479433018787	Molecular Tunnel; other site
479433018788	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
479433018789	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
479433018790	active site
479433018791	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
479433018792	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433018793	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
479433018794	NAD(P) binding site [chemical binding]; other site
479433018795	active site
479433018796	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433018797	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
479433018798	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
479433018799	active site
479433018800	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
479433018801	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
479433018802	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
479433018803	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
479433018804	putative NADP binding site [chemical binding]; other site
479433018805	active site
479433018806	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433018807	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
479433018808	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
479433018809	active site
479433018810	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
479433018811	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
479433018812	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
479433018813	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
479433018814	putative NADP binding site [chemical binding]; other site
479433018815	active site
479433018816	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433018817	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
479433018818	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
479433018819	active site
479433018820	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
479433018821	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
479433018822	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433018823	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433018824	NAD(P) binding site [chemical binding]; other site
479433018825	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
479433018826	active site
479433018827	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433018828	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
479433018829	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
479433018830	active site
479433018831	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
479433018832	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
479433018833	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
479433018834	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
479433018835	putative NADP binding site [chemical binding]; other site
479433018836	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
479433018837	active site
479433018838	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
479433018839	Erythronolide synthase docking; Region: Docking; pfam08990
479433018840	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
479433018841	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
479433018842	active site
479433018843	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
479433018844	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
479433018845	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
479433018846	putative NADP binding site [chemical binding]; other site
479433018847	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
479433018848	active site
479433018849	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
479433018850	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
479433018851	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
479433018852	active site
479433018853	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
479433018854	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
479433018855	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
479433018856	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
479433018857	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
479433018858	active site
479433018859	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
479433018860	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
479433018861	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
479433018862	putative NADP binding site [chemical binding]; other site
479433018863	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
479433018864	active site
479433018865	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
479433018866	Condensation domain; Region: Condensation; pfam00668
479433018867	pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099
479433018868	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839
479433018869	dimer interface [polypeptide binding]; other site
479433018870	active site
479433018871	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
479433018872	catalytic residues [active]
479433018873	substrate binding site [chemical binding]; other site
479433018874	Condensation domain; Region: Condensation; pfam00668
479433018875	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
479433018876	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
479433018877	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
479433018878	FkbH-like domain; Region: FkbH; TIGR01686
479433018879	Acid Phosphatase; Region: Acid_PPase; cl17256
479433018880	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433018881	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433018882	active site
479433018883	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
479433018884	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
479433018885	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
479433018886	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
479433018887	acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098
479433018888	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433018889	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922
479433018890	acyl-activating enzyme (AAE) consensus motif; other site
479433018891	acyl-activating enzyme (AAE) consensus motif; other site
479433018892	putative AMP binding site [chemical binding]; other site
479433018893	putative active site [active]
479433018894	putative CoA binding site [chemical binding]; other site
479433018895	acyl carrier protein; Provisional; Region: PRK07081
479433018896	Predicted membrane protein [Function unknown]; Region: COG2259
479433018897	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
479433018898	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
479433018899	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433018900	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
479433018901	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
479433018902	D-xylulose kinase; Region: XylB; TIGR01312
479433018903	nucleotide binding site [chemical binding]; other site
479433018904	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
479433018905	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
479433018906	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433018907	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
479433018908	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433018909	DNA binding residues [nucleotide binding]
479433018910	DNA primase, catalytic core; Region: dnaG; TIGR01391
479433018911	CHC2 zinc finger; Region: zf-CHC2; pfam01807
479433018912	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
479433018913	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
479433018914	active site
479433018915	metal binding site [ion binding]; metal-binding site
479433018916	interdomain interaction site; other site
479433018917	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
479433018918	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
479433018919	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
479433018920	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
479433018921	Zn2+ binding site [ion binding]; other site
479433018922	Mg2+ binding site [ion binding]; other site
479433018923	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
479433018924	EthD domain; Region: EthD; cl17553
479433018925	RNA polymerase factor sigma-70; Validated; Region: PRK08241
479433018926	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433018927	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433018928	DNA binding residues [nucleotide binding]
479433018929	SnoaL-like domain; Region: SnoaL_2; pfam12680
479433018930	Protein of unknown function (DUF664); Region: DUF664; pfam04978
479433018931	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
479433018932	Trp docking motif [polypeptide binding]; other site
479433018933	active site
479433018934	PQQ-like domain; Region: PQQ_2; pfam13360
479433018935	pyruvate phosphate dikinase; Provisional; Region: PRK09279
479433018936	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
479433018937	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
479433018938	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
479433018939	Uncharacterized conserved protein [Function unknown]; Region: COG2353
479433018940	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
479433018941	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
479433018942	FMN binding site [chemical binding]; other site
479433018943	active site
479433018944	catalytic residues [active]
479433018945	substrate binding site [chemical binding]; other site
479433018946	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
479433018947	glycyl-tRNA synthetase; Provisional; Region: PRK04173
479433018948	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
479433018949	motif 1; other site
479433018950	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
479433018951	active site
479433018952	motif 2; other site
479433018953	motif 3; other site
479433018954	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
479433018955	anticodon binding site; other site
479433018956	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
479433018957	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
479433018958	intersubunit interface [polypeptide binding]; other site
479433018959	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
479433018960	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
479433018961	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
479433018962	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
479433018963	dimer interface [polypeptide binding]; other site
479433018964	ABC-ATPase subunit  interface; other site
479433018965	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
479433018966	metal binding site 2 [ion binding]; metal-binding site
479433018967	putative DNA binding helix; other site
479433018968	metal binding site 1 [ion binding]; metal-binding site
479433018969	dimer interface [polypeptide binding]; other site
479433018970	structural Zn2+ binding site [ion binding]; other site
479433018971	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
479433018972	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
479433018973	catalytic residue [active]
479433018974	putative FPP diphosphate  binding site; other site
479433018975	putative FPP binding hydrophobic cleft; other site
479433018976	dimer interface [polypeptide binding]; other site
479433018977	putative IPP diphosphate binding site; other site
479433018978	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
479433018979	Recombination protein O N terminal; Region: RecO_N; pfam11967
479433018980	Recombination protein O C terminal; Region: RecO_C; pfam02565
479433018981	2-isopropylmalate synthase; Validated; Region: PRK03739
479433018982	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
479433018983	active site
479433018984	catalytic residues [active]
479433018985	metal binding site [ion binding]; metal-binding site
479433018986	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
479433018987	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
479433018988	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
479433018989	active site
479433018990	Zn binding site [ion binding]; other site
479433018991	GTPase Era; Reviewed; Region: era; PRK00089
479433018992	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
479433018993	G1 box; other site
479433018994	GTP/Mg2+ binding site [chemical binding]; other site
479433018995	Switch I region; other site
479433018996	G2 box; other site
479433018997	Switch II region; other site
479433018998	G3 box; other site
479433018999	G4 box; other site
479433019000	G5 box; other site
479433019001	KH domain; Region: KH_2; pfam07650
479433019002	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
479433019003	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
479433019004	Domain of unknown function DUF21; Region: DUF21; pfam01595
479433019005	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
479433019006	Transporter associated domain; Region: CorC_HlyC; smart01091
479433019007	metal-binding heat shock protein; Provisional; Region: PRK00016
479433019008	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
479433019009	PhoH-like protein; Region: PhoH; pfam02562
479433019010	Adenylosuccinate synthetase; Region: Adenylsucc_synt; pfam00709
479433019011	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
479433019012	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
479433019013	nucleotide binding site/active site [active]
479433019014	HIT family signature motif; other site
479433019015	catalytic residue [active]
479433019016	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
479433019017	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
479433019018	chaperone protein DnaJ; Provisional; Region: PRK14278
479433019019	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
479433019020	HSP70 interaction site [polypeptide binding]; other site
479433019021	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
479433019022	Zn binding sites [ion binding]; other site
479433019023	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
479433019024	dimer interface [polypeptide binding]; other site
479433019025	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
479433019026	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
479433019027	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
479433019028	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
479433019029	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
479433019030	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
479433019031	MOSC domain; Region: MOSC; pfam03473
479433019032	3-alpha domain; Region: 3-alpha; pfam03475
479433019033	coproporphyrinogen III oxidase; Validated; Region: PRK05628
479433019034	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433019035	FeS/SAM binding site; other site
479433019036	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433019037	NAD(P) binding site [chemical binding]; other site
479433019038	active site
479433019039	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433019040	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433019041	putative substrate translocation pore; other site
479433019042	Predicted acetyltransferase [General function prediction only]; Region: COG5628
479433019043	RNA ligase; Region: RNA_ligase; pfam09414
479433019044	AAA domain; Region: AAA_33; pfam13671
479433019045	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
479433019046	active site
479433019047	Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains; Region: TDP2; cd09080
479433019048	putative catalytic site [active]
479433019049	putative metal binding site [ion binding]; other site
479433019050	putative phosphate binding site [ion binding]; other site
479433019051	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
479433019052	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
479433019053	metal binding triad [ion binding]; metal-binding site
479433019054	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
479433019055	GTP-binding protein LepA; Provisional; Region: PRK05433
479433019056	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
479433019057	G1 box; other site
479433019058	putative GEF interaction site [polypeptide binding]; other site
479433019059	GTP/Mg2+ binding site [chemical binding]; other site
479433019060	Switch I region; other site
479433019061	G2 box; other site
479433019062	G3 box; other site
479433019063	Switch II region; other site
479433019064	G4 box; other site
479433019065	G5 box; other site
479433019066	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
479433019067	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
479433019068	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
479433019069	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
479433019070	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433019071	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433019072	active site
479433019073	ATP binding site [chemical binding]; other site
479433019074	substrate binding site [chemical binding]; other site
479433019075	activation loop (A-loop); other site
479433019076	hypothetical protein; Reviewed; Region: PRK07914
479433019077	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
479433019078	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
479433019079	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
479433019080	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
479433019081	Competence protein; Region: Competence; pfam03772
479433019082	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
479433019083	Helix-hairpin-helix motif; Region: HHH; pfam00633
479433019084	Transposase, Mutator family; Region: Transposase_mut; pfam00872
479433019085	MULE transposase domain; Region: MULE; pfam10551
479433019086	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
479433019087	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
479433019088	HflX GTPase family; Region: HflX; cd01878
479433019089	G1 box; other site
479433019090	GTP/Mg2+ binding site [chemical binding]; other site
479433019091	Switch I region; other site
479433019092	G2 box; other site
479433019093	G3 box; other site
479433019094	Switch II region; other site
479433019095	G4 box; other site
479433019096	G5 box; other site
479433019097	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433019098	sequence-specific DNA binding site [nucleotide binding]; other site
479433019099	salt bridge; other site
479433019100	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
479433019101	DNA binding site [nucleotide binding]
479433019102	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433019103	NB-ARC domain; Region: NB-ARC; pfam00931
479433019104	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433019105	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433019106	binding surface
479433019107	TPR motif; other site
479433019108	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
479433019109	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
479433019110	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
479433019111	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
479433019112	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
479433019113	Domain interface; other site
479433019114	Peptide binding site; other site
479433019115	Active site tetrad [active]
479433019116	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
479433019117	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
479433019118	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
479433019119	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
479433019120	protein binding site [polypeptide binding]; other site
479433019121	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
479433019122	Domain interface; other site
479433019123	Peptide binding site; other site
479433019124	Active site tetrad [active]
479433019125	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433019126	non-specific DNA binding site [nucleotide binding]; other site
479433019127	salt bridge; other site
479433019128	sequence-specific DNA binding site [nucleotide binding]; other site
479433019129	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
479433019130	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
479433019131	tetrameric interface [polypeptide binding]; other site
479433019132	NAD binding site [chemical binding]; other site
479433019133	catalytic residues [active]
479433019134	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
479433019135	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
479433019136	FAD dependent oxidoreductase; Region: DAO; pfam01266
479433019137	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
479433019138	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433019139	dimer interface [polypeptide binding]; other site
479433019140	conserved gate region; other site
479433019141	putative PBP binding loops; other site
479433019142	ABC-ATPase subunit interface; other site
479433019143	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
479433019144	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433019145	dimer interface [polypeptide binding]; other site
479433019146	conserved gate region; other site
479433019147	putative PBP binding loops; other site
479433019148	ABC-ATPase subunit interface; other site
479433019149	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
479433019150	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433019151	Walker A/P-loop; other site
479433019152	ATP binding site [chemical binding]; other site
479433019153	Q-loop/lid; other site
479433019154	ABC transporter signature motif; other site
479433019155	Walker B; other site
479433019156	D-loop; other site
479433019157	H-loop/switch region; other site
479433019158	TOBE domain; Region: TOBE_2; pfam08402
479433019159	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
479433019160	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
479433019161	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
479433019162	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
479433019163	tetrameric interface [polypeptide binding]; other site
479433019164	NAD binding site [chemical binding]; other site
479433019165	catalytic residues [active]
479433019166	substrate binding site [chemical binding]; other site
479433019167	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
479433019168	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
479433019169	Methyltransferase domain; Region: Methyltransf_23; pfam13489
479433019170	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433019171	S-adenosylmethionine binding site [chemical binding]; other site
479433019172	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
479433019173	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
479433019174	catalytic triad [active]
479433019175	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
479433019176	nudix motif; other site
479433019177	NAD-dependent deacetylase; Provisional; Region: PRK00481
479433019178	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
479433019179	NAD+ binding site [chemical binding]; other site
479433019180	substrate binding site [chemical binding]; other site
479433019181	Zn binding site [ion binding]; other site
479433019182	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
479433019183	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
479433019184	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433019185	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
479433019186	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
479433019187	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433019188	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
479433019189	Walker A/P-loop; other site
479433019190	ATP binding site [chemical binding]; other site
479433019191	Q-loop/lid; other site
479433019192	ABC transporter signature motif; other site
479433019193	Walker B; other site
479433019194	D-loop; other site
479433019195	H-loop/switch region; other site
479433019196	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433019197	Histidine kinase; Region: HisKA_3; pfam07730
479433019198	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433019199	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433019200	active site
479433019201	phosphorylation site [posttranslational modification]
479433019202	intermolecular recognition site; other site
479433019203	dimerization interface [polypeptide binding]; other site
479433019204	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433019205	DNA binding residues [nucleotide binding]
479433019206	dimerization interface [polypeptide binding]; other site
479433019207	Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057
479433019208	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433019209	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433019210	putative sugar binding sites [chemical binding]; other site
479433019211	Q-X-W motif; other site
479433019212	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
479433019213	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
479433019214	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
479433019215	active site
479433019216	PHP Thumb interface [polypeptide binding]; other site
479433019217	metal binding site [ion binding]; metal-binding site
479433019218	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
479433019219	generic binding surface II; other site
479433019220	generic binding surface I; other site
479433019221	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
479433019222	putative FMN binding site [chemical binding]; other site
479433019223	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
479433019224	active site
479433019225	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433019226	dimerization interface [polypeptide binding]; other site
479433019227	putative DNA binding site [nucleotide binding]; other site
479433019228	putative Zn2+ binding site [ion binding]; other site
479433019229	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
479433019230	putative hydrophobic ligand binding site [chemical binding]; other site
479433019231	fumarate hydratase; Reviewed; Region: fumC; PRK00485
479433019232	Class II fumarases; Region: Fumarase_classII; cd01362
479433019233	active site
479433019234	tetramer interface [polypeptide binding]; other site
479433019235	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
479433019236	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
479433019237	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433019238	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433019239	dimerization interface [polypeptide binding]; other site
479433019240	putative DNA binding site [nucleotide binding]; other site
479433019241	putative Zn2+ binding site [ion binding]; other site
479433019242	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
479433019243	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
479433019244	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
479433019245	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
479433019246	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433019247	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433019248	DNA binding residues [nucleotide binding]
479433019249	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
479433019250	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
479433019251	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
479433019252	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
479433019253	hydrophobic ligand binding site; other site
479433019254	MarR family; Region: MarR; pfam01047
479433019255	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433019256	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
479433019257	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433019258	Walker A/P-loop; other site
479433019259	ATP binding site [chemical binding]; other site
479433019260	Q-loop/lid; other site
479433019261	ABC transporter signature motif; other site
479433019262	Walker B; other site
479433019263	D-loop; other site
479433019264	H-loop/switch region; other site
479433019265	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
479433019266	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
479433019267	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433019268	Tannase and feruloyl esterase; Region: Tannase; pfam07519
479433019269	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433019270	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
479433019271	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
479433019272	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433019273	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
479433019274	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
479433019275	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
479433019276	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433019277	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433019278	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
479433019279	classical (c) SDRs; Region: SDR_c; cd05233
479433019280	NAD(P) binding site [chemical binding]; other site
479433019281	active site
479433019282	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
479433019283	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433019284	Amidohydrolase; Region: Amidohydro_2; pfam04909
479433019285	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
479433019286	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
479433019287	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433019288	sugar binding site [chemical binding]; other site
479433019289	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
479433019290	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433019291	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433019292	putative substrate translocation pore; other site
479433019293	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
479433019294	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433019295	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433019296	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
479433019297	dimerization interface [polypeptide binding]; other site
479433019298	substrate binding pocket [chemical binding]; other site
479433019299	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
479433019300	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433019301	dimer interface [polypeptide binding]; other site
479433019302	conserved gate region; other site
479433019303	putative PBP binding loops; other site
479433019304	ABC-ATPase subunit interface; other site
479433019305	The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506
479433019306	peptide binding site [polypeptide binding]; other site
479433019307	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
479433019308	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
479433019309	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433019310	dimer interface [polypeptide binding]; other site
479433019311	conserved gate region; other site
479433019312	putative PBP binding loops; other site
479433019313	ABC-ATPase subunit interface; other site
479433019314	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
479433019315	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433019316	Walker A/P-loop; other site
479433019317	ATP binding site [chemical binding]; other site
479433019318	Q-loop/lid; other site
479433019319	ABC transporter signature motif; other site
479433019320	Walker B; other site
479433019321	D-loop; other site
479433019322	H-loop/switch region; other site
479433019323	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
479433019324	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
479433019325	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433019326	Walker A/P-loop; other site
479433019327	ATP binding site [chemical binding]; other site
479433019328	Q-loop/lid; other site
479433019329	ABC transporter signature motif; other site
479433019330	Walker B; other site
479433019331	D-loop; other site
479433019332	H-loop/switch region; other site
479433019333	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
479433019334	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
479433019335	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
479433019336	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
479433019337	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
479433019338	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
479433019339	Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430
479433019340	Domain interface; other site
479433019341	glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535
479433019342	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
479433019343	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
479433019344	Interdomain contacts; other site
479433019345	Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430
479433019346	Domain interface; other site
479433019347	glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535
479433019348	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
479433019349	DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626
479433019350	putative ligand binding site [chemical binding]; other site
479433019351	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433019352	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
479433019353	Walker A/P-loop; other site
479433019354	ATP binding site [chemical binding]; other site
479433019355	Q-loop/lid; other site
479433019356	ABC transporter signature motif; other site
479433019357	Walker B; other site
479433019358	D-loop; other site
479433019359	H-loop/switch region; other site
479433019360	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433019361	Histidine kinase; Region: HisKA_3; pfam07730
479433019362	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433019363	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433019364	active site
479433019365	phosphorylation site [posttranslational modification]
479433019366	intermolecular recognition site; other site
479433019367	dimerization interface [polypeptide binding]; other site
479433019368	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433019369	DNA binding residues [nucleotide binding]
479433019370	dimerization interface [polypeptide binding]; other site
479433019371	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
479433019372	active site
479433019373	oxyanion hole [active]
479433019374	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433019375	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433019376	active site
479433019377	ATP binding site [chemical binding]; other site
479433019378	substrate binding site [chemical binding]; other site
479433019379	activation loop (A-loop); other site
479433019380	Bacterial SH3 domain; Region: SH3_4; pfam06347
479433019381	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
479433019382	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
479433019383	phosphopeptide binding site; other site
479433019384	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
479433019385	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
479433019386	phosphopeptide binding site; other site
479433019387	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
479433019388	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
479433019389	Walker A/P-loop; other site
479433019390	ATP binding site [chemical binding]; other site
479433019391	Q-loop/lid; other site
479433019392	ABC transporter signature motif; other site
479433019393	Walker B; other site
479433019394	D-loop; other site
479433019395	H-loop/switch region; other site
479433019396	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
479433019397	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
479433019398	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
479433019399	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433019400	active site
479433019401	ATP binding site [chemical binding]; other site
479433019402	substrate binding site [chemical binding]; other site
479433019403	Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147
479433019404	Lanthionine synthetase C-like domain associated with serine threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown; Region: LanC_SerThrkinase; cd04791
479433019405	active site
479433019406	zinc binding site [ion binding]; other site
479433019407	Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452
479433019408	Flavoprotein; Region: Flavoprotein; pfam02441
479433019409	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433019410	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433019411	putative substrate translocation pore; other site
479433019412	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433019413	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433019414	DNA binding residues [nucleotide binding]
479433019415	dimerization interface [polypeptide binding]; other site
479433019416	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
479433019417	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433019418	CsbD-like; Region: CsbD; cl17424
479433019419	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433019420	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433019421	putative DNA binding site [nucleotide binding]; other site
479433019422	putative Zn2+ binding site [ion binding]; other site
479433019423	dimerization interface [polypeptide binding]; other site
479433019424	Hemerythrin-like domain; Region: Hr-like; cd12108
479433019425	Fe binding site [ion binding]; other site
479433019426	MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
479433019427	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433019428	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433019429	ATP binding site [chemical binding]; other site
479433019430	Mg2+ binding site [ion binding]; other site
479433019431	G-X-G motif; other site
479433019432	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
479433019433	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433019434	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
479433019435	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433019436	DNA binding residues [nucleotide binding]
479433019437	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
479433019438	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433019439	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
479433019440	anti sigma factor interaction site; other site
479433019441	regulatory phosphorylation site [posttranslational modification]; other site
479433019442	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
479433019443	active site
479433019444	oxyanion hole [active]
479433019445	catalytic triad [active]
479433019446	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
479433019447	Interdomain contacts; other site
479433019448	Cytokine receptor motif; other site
479433019449	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
479433019450	active site
479433019451	metal binding site [ion binding]; metal-binding site
479433019452	homotetramer interface [polypeptide binding]; other site
479433019453	classical (c) SDRs; Region: SDR_c; cd05233
479433019454	short chain dehydrogenase; Provisional; Region: PRK07041
479433019455	NAD(P) binding site [chemical binding]; other site
479433019456	active site
479433019457	Cupin; Region: Cupin_6; pfam12852
479433019458	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
479433019459	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433019460	Protein of unknown function (DUF4240); Region: DUF4240; pfam14024
479433019461	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
479433019462	aromatic chitin/cellulose binding site residues [chemical binding]; other site
479433019463	Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046
479433019464	aromatic chitin/cellulose binding site residues [chemical binding]; other site
479433019465	Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325
479433019466	putative sugar binding site [chemical binding]; other site
479433019467	catalytic residues [active]
479433019468	NmrA-like family; Region: NmrA; pfam05368
479433019469	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433019470	NAD(P) binding site [chemical binding]; other site
479433019471	active site
479433019472	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
479433019473	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
479433019474	active site
479433019475	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433019476	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433019477	ABC-ATPase subunit interface; other site
479433019478	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
479433019479	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433019480	ABC-ATPase subunit interface; other site
479433019481	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433019482	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433019483	Cellulose binding domain; Region: CBM_3; pfam00942
479433019484	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413
479433019485	active site
479433019486	catalytic residues [active]
479433019487	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433019488	DNA-binding site [nucleotide binding]; DNA binding site
479433019489	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
479433019490	UTRA domain; Region: UTRA; pfam07702
479433019491	chorismate mutase; Provisional; Region: PRK09239
479433019492	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433019493	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433019494	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
479433019495	Cupin domain; Region: Cupin_2; cl17218
479433019496	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
479433019497	active site
479433019498	catalytic triad [active]
479433019499	calcium binding site [ion binding]; other site
479433019500	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
479433019501	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
479433019502	inhibitor-cofactor binding pocket; inhibition site
479433019503	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433019504	catalytic residue [active]
479433019505	Clp amino terminal domain; Region: Clp_N; pfam02861
479433019506	Clp amino terminal domain; Region: Clp_N; pfam02861
479433019507	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893
479433019508	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
479433019509	metal binding site [ion binding]; metal-binding site
479433019510	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
479433019511	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
479433019512	ligand binding site [chemical binding]; other site
479433019513	flexible hinge region; other site
479433019514	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
479433019515	NPCBM/NEW2 domain; Region: NPCBM; cl07060
479433019516	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
479433019517	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
479433019518	putative switch regulator; other site
479433019519	non-specific DNA interactions [nucleotide binding]; other site
479433019520	DNA binding site [nucleotide binding]
479433019521	sequence specific DNA binding site [nucleotide binding]; other site
479433019522	putative cAMP binding site [chemical binding]; other site
479433019523	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433019524	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
479433019525	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
479433019526	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433019527	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433019528	putative sugar binding sites [chemical binding]; other site
479433019529	Q-X-W motif; other site
479433019530	Right handed beta helix region; Region: Beta_helix; pfam13229
479433019531	alpha-galactosidase; Region: PLN02808; cl17638
479433019532	Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081
479433019533	Ca binding site [ion binding]; other site
479433019534	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433019535	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
479433019536	MarR family; Region: MarR_2; pfam12802
479433019537	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
479433019538	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
479433019539	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433019540	sequence-specific DNA binding site [nucleotide binding]; other site
479433019541	salt bridge; other site
479433019542	amino acid permease (GABA permease); Region: 2A0304; TIGR00907
479433019543	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
479433019544	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
479433019545	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433019546	Coenzyme A binding pocket [chemical binding]; other site
479433019547	MMPL family; Region: MMPL; pfam03176
479433019548	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
479433019549	active site
479433019550	catalytic triad [active]
479433019551	oxyanion hole [active]
479433019552	cytokinin dehydrogenase; Region: PLN02441
479433019553	FAD binding domain; Region: FAD_binding_4; pfam01565
479433019554	Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265
479433019555	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
479433019556	Methyltransferase domain; Region: Methyltransf_23; pfam13489
479433019557	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433019558	S-adenosylmethionine binding site [chemical binding]; other site
479433019559	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
479433019560	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
479433019561	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433019562	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433019563	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433019564	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433019565	putative substrate translocation pore; other site
479433019566	MarR family; Region: MarR; pfam01047
479433019567	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
479433019568	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
479433019569	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
479433019570	Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182
479433019571	active site
479433019572	catalytic residues [active]
479433019573	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433019574	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433019575	putative sugar binding sites [chemical binding]; other site
479433019576	Q-X-W motif; other site
479433019577	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433019578	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433019579	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433019580	DNA binding residues [nucleotide binding]
479433019581	hypothetical protein; Provisional; Region: PRK07588
479433019582	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
479433019583	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433019584	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433019585	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433019586	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
479433019587	putative NAD(P) binding site [chemical binding]; other site
479433019588	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
479433019589	active site
479433019590	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
479433019591	nudix motif; other site
479433019592	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433019593	Cytochrome P450; Region: p450; cl12078
479433019594	putative acetyltransferase; Provisional; Region: PRK03624
479433019595	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433019596	Coenzyme A binding pocket [chemical binding]; other site
479433019597	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
479433019598	catalytic core [active]
479433019599	Oligomerisation domain; Region: Oligomerisation; pfam02410
479433019600	cell division protein ZipA; Provisional; Region: PRK03427
479433019601	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
479433019602	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
479433019603	active site
479433019604	(T/H)XGH motif; other site
479433019605	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
479433019606	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
479433019607	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
479433019608	putative catalytic cysteine [active]
479433019609	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
479433019610	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
479433019611	DNA binding residues [nucleotide binding]
479433019612	drug binding residues [chemical binding]; other site
479433019613	dimer interface [polypeptide binding]; other site
479433019614	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
479433019615	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433019616	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433019617	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433019618	DNA binding residues [nucleotide binding]
479433019619	gamma-glutamyl kinase; Provisional; Region: PRK05429
479433019620	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
479433019621	nucleotide binding site [chemical binding]; other site
479433019622	homotetrameric interface [polypeptide binding]; other site
479433019623	putative phosphate binding site [ion binding]; other site
479433019624	putative allosteric binding site; other site
479433019625	PUA domain; Region: PUA; pfam01472
479433019626	GTPase CgtA; Reviewed; Region: obgE; PRK12296
479433019627	GTP1/OBG; Region: GTP1_OBG; pfam01018
479433019628	Obg GTPase; Region: Obg; cd01898
479433019629	G1 box; other site
479433019630	GTP/Mg2+ binding site [chemical binding]; other site
479433019631	Switch I region; other site
479433019632	G2 box; other site
479433019633	G3 box; other site
479433019634	Switch II region; other site
479433019635	G4 box; other site
479433019636	G5 box; other site
479433019637	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
479433019638	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
479433019639	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
479433019640	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
479433019641	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
479433019642	homodimer interface [polypeptide binding]; other site
479433019643	oligonucleotide binding site [chemical binding]; other site
479433019644	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
479433019645	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
479433019646	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433019647	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433019648	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433019649	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
479433019650	benzoate transporter; Region: benE; TIGR00843
479433019651	benzoate transporter; Region: benE; TIGR00843
479433019652	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433019653	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433019654	non-specific DNA binding site [nucleotide binding]; other site
479433019655	salt bridge; other site
479433019656	sequence-specific DNA binding site [nucleotide binding]; other site
479433019657	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
479433019658	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
479433019659	nucleotide binding site/active site [active]
479433019660	HIT family signature motif; other site
479433019661	catalytic residue [active]
479433019662	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
479433019663	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
479433019664	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
479433019665	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
479433019666	B12 binding site [chemical binding]; other site
479433019667	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433019668	FeS/SAM binding site; other site
479433019669	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
479433019670	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
479433019671	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
479433019672	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
479433019673	rod shape-determining protein MreD; Region: MreD; cl01087
479433019674	rod shape-determining protein MreC; Provisional; Region: PRK13922
479433019675	rod shape-determining protein MreC; Region: MreC; pfam04085
479433019676	rod shape-determining protein MreB; Provisional; Region: PRK13927
479433019677	MreB and similar proteins; Region: MreB_like; cd10225
479433019678	nucleotide binding site [chemical binding]; other site
479433019679	Mg binding site [ion binding]; other site
479433019680	putative protofilament interaction site [polypeptide binding]; other site
479433019681	RodZ interaction site [polypeptide binding]; other site
479433019682	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
479433019683	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
479433019684	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
479433019685	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
479433019686	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
479433019687	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
479433019688	HIGH motif; other site
479433019689	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
479433019690	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
479433019691	active site
479433019692	KMSKS motif; other site
479433019693	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
479433019694	tRNA binding surface [nucleotide binding]; other site
479433019695	anticodon binding site; other site
479433019696	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
479433019697	PemK-like protein; Region: PemK; pfam02452
479433019698	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
479433019699	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
479433019700	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
479433019701	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433019702	Walker A motif; other site
479433019703	ATP binding site [chemical binding]; other site
479433019704	Walker B motif; other site
479433019705	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
479433019706	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
479433019707	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
479433019708	oligomer interface [polypeptide binding]; other site
479433019709	active site residues [active]
479433019710	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
479433019711	Clp protease; Region: CLP_protease; pfam00574
479433019712	oligomer interface [polypeptide binding]; other site
479433019713	active site residues [active]
479433019714	trigger factor; Provisional; Region: tig; PRK01490
479433019715	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
479433019716	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
479433019717	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433019718	Coenzyme A binding pocket [chemical binding]; other site
479433019719	hypothetical protein; Provisional; Region: PRK11408
479433019720	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
479433019721	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
479433019722	NAD binding site [chemical binding]; other site
479433019723	catalytic residues [active]
479433019724	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
479433019725	Transport protein; Region: actII; TIGR00833
479433019726	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
479433019727	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
479433019728	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
479433019729	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
479433019730	putative DNA binding site [nucleotide binding]; other site
479433019731	catalytic residue [active]
479433019732	putative H2TH interface [polypeptide binding]; other site
479433019733	putative catalytic residues [active]
479433019734	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
479433019735	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
479433019736	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
479433019737	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
479433019738	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
479433019739	active site
479433019740	NTP binding site [chemical binding]; other site
479433019741	metal binding triad [ion binding]; metal-binding site
479433019742	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433019743	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433019744	non-specific DNA binding site [nucleotide binding]; other site
479433019745	salt bridge; other site
479433019746	sequence-specific DNA binding site [nucleotide binding]; other site
479433019747	Domain of unknown function (DUF955); Region: DUF955; pfam06114
479433019748	Protein of unknown function (DUF3892); Region: DUF3892; pfam13031
479433019749	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
479433019750	Domain of unknown function DUF87; Region: DUF87; pfam01935
479433019751	HerA helicase [Replication, recombination, and repair]; Region: COG0433
479433019752	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
479433019753	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
479433019754	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
479433019755	motif II; other site
479433019756	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433019757	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433019758	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433019759	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433019760	non-specific DNA binding site [nucleotide binding]; other site
479433019761	salt bridge; other site
479433019762	sequence-specific DNA binding site [nucleotide binding]; other site
479433019763	AAA-like domain; Region: AAA_10; pfam12846
479433019764	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
479433019765	Walker B motif; other site
479433019766	Replication-relaxation; Region: Replic_Relax; pfam13814
479433019767	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
479433019768	DNA methylase; Region: N6_N4_Mtase; pfam01555
479433019769	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
479433019770	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
479433019771	catalytic residues [active]
479433019772	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
479433019773	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
479433019774	Zn binding site [ion binding]; other site
479433019775	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
479433019776	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
479433019777	active site
479433019778	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
479433019779	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
479433019780	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
479433019781	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433019782	Mechanosensitive ion channel; Region: MS_channel; pfam00924
479433019783	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
479433019784	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433019785	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
479433019786	Walker A/P-loop; other site
479433019787	ATP binding site [chemical binding]; other site
479433019788	Q-loop/lid; other site
479433019789	ABC transporter signature motif; other site
479433019790	Walker B; other site
479433019791	D-loop; other site
479433019792	H-loop/switch region; other site
479433019793	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
479433019794	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
479433019795	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433019796	Histidine kinase; Region: HisKA_3; pfam07730
479433019797	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433019798	ATP binding site [chemical binding]; other site
479433019799	Mg2+ binding site [ion binding]; other site
479433019800	G-X-G motif; other site
479433019801	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433019802	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433019803	active site
479433019804	phosphorylation site [posttranslational modification]
479433019805	intermolecular recognition site; other site
479433019806	dimerization interface [polypeptide binding]; other site
479433019807	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433019808	DNA binding residues [nucleotide binding]
479433019809	dimerization interface [polypeptide binding]; other site
479433019810	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
479433019811	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433019812	MarR family; Region: MarR_2; pfam12802
479433019813	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433019814	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
479433019815	nucleotide binding site [chemical binding]; other site
479433019816	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
479433019817	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
479433019818	NAD binding site [chemical binding]; other site
479433019819	sugar binding site [chemical binding]; other site
479433019820	divalent metal binding site [ion binding]; other site
479433019821	tetramer (dimer of dimers) interface [polypeptide binding]; other site
479433019822	dimer interface [polypeptide binding]; other site
479433019823	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
479433019824	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
479433019825	Predicted membrane protein [Function unknown]; Region: COG3463
479433019826	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
479433019827	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
479433019828	apolar tunnel; other site
479433019829	heme binding site [chemical binding]; other site
479433019830	dimerization interface [polypeptide binding]; other site
479433019831	MarR family; Region: MarR_2; cl17246
479433019832	YceI-like domain; Region: YceI; pfam04264
479433019833	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
479433019834	active site
479433019835	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
479433019836	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433019837	Walker A/P-loop; other site
479433019838	ATP binding site [chemical binding]; other site
479433019839	Q-loop/lid; other site
479433019840	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
479433019841	ABC transporter; Region: ABC_tran_2; pfam12848
479433019842	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
479433019843	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
479433019844	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
479433019845	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
479433019846	dimer interface [polypeptide binding]; other site
479433019847	ssDNA binding site [nucleotide binding]; other site
479433019848	tetramer (dimer of dimers) interface [polypeptide binding]; other site
479433019849	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
479433019850	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
479433019851	acyl-activating enzyme (AAE) consensus motif; other site
479433019852	putative AMP binding site [chemical binding]; other site
479433019853	putative active site [active]
479433019854	putative CoA binding site [chemical binding]; other site
479433019855	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
479433019856	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
479433019857	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
479433019858	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
479433019859	Phosphoesterase family; Region: Phosphoesterase; pfam04185
479433019860	Domain of unknown function (DUF756); Region: DUF756; pfam05506
479433019861	Domain of unknown function (DUF756); Region: DUF756; pfam05506
479433019862	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
479433019863	sugar binding site [chemical binding]; other site
479433019864	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433019865	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433019866	putative substrate translocation pore; other site
479433019867	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
479433019868	FAD binding domain; Region: FAD_binding_4; pfam01565
479433019869	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
479433019870	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
479433019871	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
479433019872	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
479433019873	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
479433019874	active site
479433019875	pyruvate dehydrogenase; Provisional; Region: PRK06546
479433019876	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
479433019877	PYR/PP interface [polypeptide binding]; other site
479433019878	tetramer interface [polypeptide binding]; other site
479433019879	dimer interface [polypeptide binding]; other site
479433019880	TPP binding site [chemical binding]; other site
479433019881	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
479433019882	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
479433019883	TPP-binding site [chemical binding]; other site
479433019884	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
479433019885	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433019886	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
479433019887	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
479433019888	Active Sites [active]
479433019889	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
479433019890	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
479433019891	Active Sites [active]
479433019892	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
479433019893	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
479433019894	CysD dimerization site [polypeptide binding]; other site
479433019895	G1 box; other site
479433019896	putative GEF interaction site [polypeptide binding]; other site
479433019897	GTP/Mg2+ binding site [chemical binding]; other site
479433019898	Switch I region; other site
479433019899	G2 box; other site
479433019900	G3 box; other site
479433019901	Switch II region; other site
479433019902	G4 box; other site
479433019903	G5 box; other site
479433019904	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
479433019905	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
479433019906	NMT1-like family; Region: NMT1_2; pfam13379
479433019907	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
479433019908	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
479433019909	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
479433019910	Walker A/P-loop; other site
479433019911	ATP binding site [chemical binding]; other site
479433019912	Q-loop/lid; other site
479433019913	ABC transporter signature motif; other site
479433019914	Walker B; other site
479433019915	D-loop; other site
479433019916	H-loop/switch region; other site
479433019917	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
479433019918	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433019919	dimer interface [polypeptide binding]; other site
479433019920	conserved gate region; other site
479433019921	putative PBP binding loops; other site
479433019922	ABC-ATPase subunit interface; other site
479433019923	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
479433019924	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
479433019925	putative active site [active]
479433019926	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
479433019927	active site
479433019928	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
479433019929	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
479433019930	NADP binding site [chemical binding]; other site
479433019931	dimer interface [polypeptide binding]; other site
479433019932	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433019933	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
479433019934	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
479433019935	hypothetical protein; Provisional; Region: PRK14059
479433019936	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
479433019937	methionine sulfoxide reductase B; Provisional; Region: PRK00222
479433019938	SelR domain; Region: SelR; pfam01641
479433019939	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
479433019940	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433019941	Walker A/P-loop; other site
479433019942	ATP binding site [chemical binding]; other site
479433019943	Q-loop/lid; other site
479433019944	ABC transporter signature motif; other site
479433019945	Walker B; other site
479433019946	D-loop; other site
479433019947	H-loop/switch region; other site
479433019948	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
479433019949	nudix motif; other site
479433019950	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
479433019951	Moco binding site; other site
479433019952	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
479433019953	Oxidoreductase molybdopterin binding domain; Region: Oxidored_molyb; pfam00174
479433019954	metal coordination site [ion binding]; other site
479433019955	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
479433019956	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
479433019957	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433019958	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433019959	active site
479433019960	phosphorylation site [posttranslational modification]
479433019961	intermolecular recognition site; other site
479433019962	dimerization interface [polypeptide binding]; other site
479433019963	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433019964	DNA binding site [nucleotide binding]
479433019965	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433019966	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433019967	dimerization interface [polypeptide binding]; other site
479433019968	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433019969	dimer interface [polypeptide binding]; other site
479433019970	phosphorylation site [posttranslational modification]
479433019971	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433019972	ATP binding site [chemical binding]; other site
479433019973	Mg2+ binding site [ion binding]; other site
479433019974	G-X-G motif; other site
479433019975	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
479433019976	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
479433019977	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
479433019978	lipoate-protein ligase B; Provisional; Region: PRK14345
479433019979	lipoyl synthase; Provisional; Region: PRK05481
479433019980	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433019981	FeS/SAM binding site; other site
479433019982	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
479433019983	RDD family; Region: RDD; pfam06271
479433019984	glutamine synthetase, type I; Region: GlnA; TIGR00653
479433019985	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
479433019986	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
479433019987	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
479433019988	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
479433019989	putative active site [active]
479433019990	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
479433019991	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433019992	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433019993	active site
479433019994	phosphorylation site [posttranslational modification]
479433019995	intermolecular recognition site; other site
479433019996	dimerization interface [polypeptide binding]; other site
479433019997	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433019998	DNA binding residues [nucleotide binding]
479433019999	dimerization interface [polypeptide binding]; other site
479433020000	Histidine kinase; Region: HisKA_3; pfam07730
479433020001	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433020002	CAAX protease self-immunity; Region: Abi; pfam02517
479433020003	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433020004	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433020005	active site
479433020006	ATP binding site [chemical binding]; other site
479433020007	substrate binding site [chemical binding]; other site
479433020008	activation loop (A-loop); other site
479433020009	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
479433020010	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433020011	Walker A/P-loop; other site
479433020012	ATP binding site [chemical binding]; other site
479433020013	Q-loop/lid; other site
479433020014	ABC transporter signature motif; other site
479433020015	Walker B; other site
479433020016	D-loop; other site
479433020017	H-loop/switch region; other site
479433020018	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
479433020019	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433020020	dimer interface [polypeptide binding]; other site
479433020021	conserved gate region; other site
479433020022	putative PBP binding loops; other site
479433020023	ABC-ATPase subunit interface; other site
479433020024	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433020025	dimer interface [polypeptide binding]; other site
479433020026	conserved gate region; other site
479433020027	ABC-ATPase subunit interface; other site
479433020028	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
479433020029	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
479433020030	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433020031	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
479433020032	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
479433020033	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433020034	putative substrate translocation pore; other site
479433020035	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433020036	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
479433020037	RibD C-terminal domain; Region: RibD_C; cl17279
479433020038	SnoaL-like domain; Region: SnoaL_2; pfam12680
479433020039	N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181
479433020040	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
479433020041	putative active site [active]
479433020042	putative ligand binding site [chemical binding]; other site
479433020043	putative NAD(P) binding site [chemical binding]; other site
479433020044	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
479433020045	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
479433020046	MMPL family; Region: MMPL; pfam03176
479433020047	MMPL family; Region: MMPL; pfam03176
479433020048	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433020049	putative substrate translocation pore; other site
479433020050	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
479433020051	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433020052	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433020053	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433020054	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
479433020055	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
479433020056	active site
479433020057	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433020058	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433020059	active site
479433020060	catalytic tetrad [active]
479433020061	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
479433020062	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
479433020063	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433020064	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433020065	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
479433020066	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
479433020067	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
479433020068	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433020069	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
479433020070	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
479433020071	active site
479433020072	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433020073	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
479433020074	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
479433020075	active site
479433020076	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
479433020077	CoA binding domain; Region: CoA_binding_2; pfam13380
479433020078	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
479433020079	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
479433020080	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
479433020081	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
479433020082	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
479433020083	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
479433020084	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
479433020085	[2Fe-2S] cluster binding site [ion binding]; other site
479433020086	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
479433020087	alpha subunit interface [polypeptide binding]; other site
479433020088	active site
479433020089	substrate binding site [chemical binding]; other site
479433020090	Fe binding site [ion binding]; other site
479433020091	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
479433020092	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433020093	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
479433020094	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
479433020095	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
479433020096	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433020097	dimer interface [polypeptide binding]; other site
479433020098	conserved gate region; other site
479433020099	putative PBP binding loops; other site
479433020100	ABC-ATPase subunit interface; other site
479433020101	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
479433020102	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
479433020103	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
479433020104	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433020105	Walker A/P-loop; other site
479433020106	ATP binding site [chemical binding]; other site
479433020107	Q-loop/lid; other site
479433020108	ABC transporter signature motif; other site
479433020109	Walker B; other site
479433020110	D-loop; other site
479433020111	H-loop/switch region; other site
479433020112	TOBE domain; Region: TOBE_2; pfam08402
479433020113	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
479433020114	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
479433020115	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
479433020116	tetrameric interface [polypeptide binding]; other site
479433020117	NAD binding site [chemical binding]; other site
479433020118	catalytic residues [active]
479433020119	substrate binding site [chemical binding]; other site
479433020120	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
479433020121	Transcriptional regulators [Transcription]; Region: FadR; COG2186
479433020122	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433020123	DNA-binding site [nucleotide binding]; DNA binding site
479433020124	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
479433020125	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
479433020126	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
479433020127	active site
479433020128	catalytic triad [active]
479433020129	calcium binding site [ion binding]; other site
479433020130	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
479433020131	aromatic chitin/cellulose binding site residues [chemical binding]; other site
479433020132	CHAP domain; Region: CHAP; cl17642
479433020133	PKD domain; Region: PKD; pfam00801
479433020134	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
479433020135	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
479433020136	putative active site [active]
479433020137	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
479433020138	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
479433020139	DNA-binding site [nucleotide binding]; DNA binding site
479433020140	RNA-binding motif; other site
479433020141	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
479433020142	putative metal binding site [ion binding]; other site
479433020143	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
479433020144	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
479433020145	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
479433020146	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
479433020147	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433020148	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433020149	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433020150	putative substrate translocation pore; other site
479433020151	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
479433020152	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
479433020153	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433020154	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433020155	LysR substrate binding domain; Region: LysR_substrate; pfam03466
479433020156	dimerization interface [polypeptide binding]; other site
479433020157	Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206
479433020158	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
479433020159	PKC phosphorylation site [posttranslational modification]; other site
479433020160	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
479433020161	PKC phosphorylation site [posttranslational modification]; other site
479433020162	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
479433020163	putative metal binding site [ion binding]; other site
479433020164	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
479433020165	putative metal binding site [ion binding]; other site
479433020166	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
479433020167	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433020168	putative NAD(P) binding site [chemical binding]; other site
479433020169	Imelysin; Region: Peptidase_M75; pfam09375
479433020170	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
479433020171	Phosphoesterase family; Region: Phosphoesterase; pfam04185
479433020172	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
479433020173	Transcription factor WhiB; Region: Whib; pfam02467
479433020174	Predicted transcriptional regulators [Transcription]; Region: COG1733
479433020175	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
479433020176	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433020177	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433020178	putative sugar binding sites [chemical binding]; other site
479433020179	Q-X-W motif; other site
479433020180	Alginate lyase; Region: Alginate_lyase2; pfam08787
479433020181	Domain of unknown function (DUF4234); Region: DUF4234; pfam14018
479433020182	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433020183	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
479433020184	NAD(P) binding site [chemical binding]; other site
479433020185	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
479433020186	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433020187	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
479433020188	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
479433020189	putative NAD(P) binding site [chemical binding]; other site
479433020190	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
479433020191	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
479433020192	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
479433020193	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
479433020194	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
479433020195	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433020196	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
479433020197	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
479433020198	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
479433020199	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
479433020200	Cupin domain; Region: Cupin_2; cl17218
479433020201	MarR family; Region: MarR_2; pfam12802
479433020202	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
479433020203	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
479433020204	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
479433020205	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
479433020206	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433020207	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433020208	non-specific DNA binding site [nucleotide binding]; other site
479433020209	salt bridge; other site
479433020210	sequence-specific DNA binding site [nucleotide binding]; other site
479433020211	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
479433020212	extended (e) SDRs; Region: SDR_e; cd08946
479433020213	NAD(P) binding site [chemical binding]; other site
479433020214	active site
479433020215	substrate binding site [chemical binding]; other site
479433020216	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
479433020217	5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620
479433020218	catalytic residue [active]
479433020219	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433020220	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433020221	dimer interface [polypeptide binding]; other site
479433020222	conserved gate region; other site
479433020223	putative PBP binding loops; other site
479433020224	ABC-ATPase subunit interface; other site
479433020225	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433020226	dimer interface [polypeptide binding]; other site
479433020227	conserved gate region; other site
479433020228	putative PBP binding loops; other site
479433020229	ABC-ATPase subunit interface; other site
479433020230	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433020231	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433020232	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
479433020233	Transcriptional regulator [Transcription]; Region: IclR; COG1414
479433020234	Bacterial transcriptional regulator; Region: IclR; pfam01614
479433020235	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
479433020236	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433020237	putative substrate translocation pore; other site
479433020238	Protein of unknown function (DUF2000); Region: DUF2000; pfam09391
479433020239	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433020240	dimerization interface [polypeptide binding]; other site
479433020241	putative DNA binding site [nucleotide binding]; other site
479433020242	putative Zn2+ binding site [ion binding]; other site
479433020243	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433020244	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433020245	putative substrate translocation pore; other site
479433020246	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433020247	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
479433020248	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
479433020249	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433020250	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433020251	putative substrate translocation pore; other site
479433020252	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433020253	salt bridge; other site
479433020254	non-specific DNA binding site [nucleotide binding]; other site
479433020255	sequence-specific DNA binding site [nucleotide binding]; other site
479433020256	TIR domain; Region: TIR_2; pfam13676
479433020257	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433020258	non-specific DNA binding site [nucleotide binding]; other site
479433020259	salt bridge; other site
479433020260	sequence-specific DNA binding site [nucleotide binding]; other site
479433020261	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
479433020262	ATP binding site [chemical binding]; other site
479433020263	substrate interface [chemical binding]; other site
479433020264	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
479433020265	Domain of unknown function (DUF377); Region: DUF377; pfam04041
479433020266	active site
479433020267	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
479433020268	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
479433020269	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
479433020270	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
479433020271	classical (c) SDRs; Region: SDR_c; cd05233
479433020272	NAD(P) binding site [chemical binding]; other site
479433020273	active site
479433020274	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433020275	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
479433020276	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
479433020277	Family description; Region: UvrD_C_2; pfam13538
479433020278	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
479433020279	hypothetical protein; Provisional; Region: PRK07208
479433020280	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
479433020281	UDP-galactopyranose mutase; Region: GLF; pfam03275
479433020282	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
479433020283	Domain of unknown function DUF20; Region: UPF0118; pfam01594
479433020284	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
479433020285	oligomerisation interface [polypeptide binding]; other site
479433020286	mobile loop; other site
479433020287	roof hairpin; other site
479433020288	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
479433020289	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
479433020290	catalytic triad [active]
479433020291	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
479433020292	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
479433020293	active site
479433020294	dimerization interface [polypeptide binding]; other site
479433020295	ribonuclease PH; Reviewed; Region: rph; PRK00173
479433020296	Ribonuclease PH; Region: RNase_PH_bact; cd11362
479433020297	hexamer interface [polypeptide binding]; other site
479433020298	active site
479433020299	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
479433020300	glutamate racemase; Provisional; Region: PRK00865
479433020301	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
479433020302	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
479433020303	dimer interface [polypeptide binding]; other site
479433020304	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433020305	catalytic residue [active]
479433020306	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
479433020307	MoaE interaction surface [polypeptide binding]; other site
479433020308	MoeB interaction surface [polypeptide binding]; other site
479433020309	thiocarboxylated glycine; other site
479433020310	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
479433020311	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
479433020312	active site
479433020313	dimer interface [polypeptide binding]; other site
479433020314	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
479433020315	dimer interface [polypeptide binding]; other site
479433020316	active site
479433020317	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433020318	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433020319	active site
479433020320	phosphorylation site [posttranslational modification]
479433020321	intermolecular recognition site; other site
479433020322	dimerization interface [polypeptide binding]; other site
479433020323	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433020324	DNA binding site [nucleotide binding]
479433020325	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433020326	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433020327	dimerization interface [polypeptide binding]; other site
479433020328	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433020329	dimer interface [polypeptide binding]; other site
479433020330	phosphorylation site [posttranslational modification]
479433020331	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433020332	ATP binding site [chemical binding]; other site
479433020333	Mg2+ binding site [ion binding]; other site
479433020334	G-X-G motif; other site
479433020335	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
479433020336	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
479433020337	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
479433020338	TPP-binding site [chemical binding]; other site
479433020339	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
479433020340	Uncharacterized conserved protein [Function unknown]; Region: COG3595
479433020341	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
479433020342	Predicted transcriptional regulators [Transcription]; Region: COG1695
479433020343	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
479433020344	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
479433020345	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
479433020346	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433020347	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
479433020348	Walker A motif; other site
479433020349	ATP binding site [chemical binding]; other site
479433020350	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433020351	NAD(P) binding site [chemical binding]; other site
479433020352	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433020353	active site
479433020354	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
479433020355	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
479433020356	Substrate binding site [chemical binding]; other site
479433020357	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
479433020358	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433020359	NAD(P) binding site [chemical binding]; other site
479433020360	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
479433020361	Part of AAA domain; Region: AAA_19; pfam13245
479433020362	Family description; Region: UvrD_C_2; pfam13538
479433020363	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433020364	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433020365	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433020366	MarR family; Region: MarR; pfam01047
479433020367	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
479433020368	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
479433020369	NAD(P) binding site [chemical binding]; other site
479433020370	catalytic residues [active]
479433020371	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
479433020372	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
479433020373	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
479433020374	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
479433020375	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
479433020376	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
479433020377	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
479433020378	nucleotide binding region [chemical binding]; other site
479433020379	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
479433020380	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433020381	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
479433020382	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
479433020383	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433020384	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433020385	active site
479433020386	phosphorylation site [posttranslational modification]
479433020387	intermolecular recognition site; other site
479433020388	dimerization interface [polypeptide binding]; other site
479433020389	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433020390	DNA binding residues [nucleotide binding]
479433020391	dimerization interface [polypeptide binding]; other site
479433020392	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
479433020393	30S subunit binding site; other site
479433020394	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
479433020395	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
479433020396	active site
479433020397	lipoprotein LpqB; Provisional; Region: PRK13613
479433020398	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433020399	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
479433020400	dimerization interface [polypeptide binding]; other site
479433020401	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433020402	dimer interface [polypeptide binding]; other site
479433020403	phosphorylation site [posttranslational modification]
479433020404	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433020405	ATP binding site [chemical binding]; other site
479433020406	Mg2+ binding site [ion binding]; other site
479433020407	G-X-G motif; other site
479433020408	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433020409	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433020410	active site
479433020411	phosphorylation site [posttranslational modification]
479433020412	intermolecular recognition site; other site
479433020413	dimerization interface [polypeptide binding]; other site
479433020414	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433020415	DNA binding site [nucleotide binding]
479433020416	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
479433020417	MoxR-like ATPases [General function prediction only]; Region: COG0714
479433020418	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433020419	Walker A motif; other site
479433020420	ATP binding site [chemical binding]; other site
479433020421	Walker B motif; other site
479433020422	arginine finger; other site
479433020423	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
479433020424	Protein of unknown function DUF58; Region: DUF58; pfam01882
479433020425	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
479433020426	RDD family; Region: RDD; pfam06271
479433020427	Adenosylhomocysteinase; Provisional; Region: PTZ00075
479433020428	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
479433020429	homotetramer interface [polypeptide binding]; other site
479433020430	ligand binding site [chemical binding]; other site
479433020431	catalytic site [active]
479433020432	NAD binding site [chemical binding]; other site
479433020433	Trm112p-like protein; Region: Trm112p; cl01066
479433020434	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
479433020435	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
479433020436	active site
479433020437	substrate binding site [chemical binding]; other site
479433020438	metal binding site [ion binding]; metal-binding site
479433020439	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
479433020440	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
479433020441	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
479433020442	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
479433020443	Probable Catalytic site; other site
479433020444	metal-binding site
479433020445	Transcription factor WhiB; Region: Whib; pfam02467
479433020446	LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606
479433020447	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
479433020448	dimer interface [polypeptide binding]; other site
479433020449	phosphate binding site [ion binding]; other site
479433020450	F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294
479433020451	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
479433020452	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
479433020453	putative FMN binding site [chemical binding]; other site
479433020454	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
479433020455	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433020456	MarR family; Region: MarR_2; pfam12802
479433020457	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
479433020458	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
479433020459	minor groove reading motif; other site
479433020460	helix-hairpin-helix signature motif; other site
479433020461	substrate binding pocket [chemical binding]; other site
479433020462	active site
479433020463	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
479433020464	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
479433020465	active site
479433020466	Substrate binding site; other site
479433020467	Mg++ binding site; other site
479433020468	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
479433020469	N-terminal domain interface [polypeptide binding]; other site
479433020470	TIGR03089 family protein; Region: TIGR03089
479433020471	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
479433020472	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
479433020473	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
479433020474	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
479433020475	epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247
479433020476	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
479433020477	motif II; other site
479433020478	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
479433020479	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
479433020480	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
479433020481	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
479433020482	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
479433020483	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
479433020484	active site
479433020485	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699
479433020486	nudix motif; other site
479433020487	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
479433020488	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
479433020489	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
479433020490	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
479433020491	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
479433020492	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
479433020493	Ligand binding site; other site
479433020494	Putative Catalytic site; other site
479433020495	DXD motif; other site
479433020496	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
479433020497	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
479433020498	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
479433020499	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
479433020500	inhibitor-cofactor binding pocket; inhibition site
479433020501	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433020502	catalytic residue [active]
479433020503	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
479433020504	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
479433020505	putative trimer interface [polypeptide binding]; other site
479433020506	putative active site [active]
479433020507	putative substrate binding site [chemical binding]; other site
479433020508	putative CoA binding site [chemical binding]; other site
479433020509	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
479433020510	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
479433020511	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
479433020512	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
479433020513	Walker A/P-loop; other site
479433020514	ATP binding site [chemical binding]; other site
479433020515	Q-loop/lid; other site
479433020516	ABC transporter signature motif; other site
479433020517	Walker B; other site
479433020518	D-loop; other site
479433020519	H-loop/switch region; other site
479433020520	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
479433020521	ABC-2 type transporter; Region: ABC2_membrane; cl17235
479433020522	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
479433020523	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
479433020524	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
479433020525	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433020526	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433020527	DNA binding residues [nucleotide binding]
479433020528	dimerization interface [polypeptide binding]; other site
479433020529	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
479433020530	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
479433020531	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
479433020532	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
479433020533	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
479433020534	active site
479433020535	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
479433020536	homodimer interface [polypeptide binding]; other site
479433020537	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
479433020538	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
479433020539	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
479433020540	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
479433020541	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
479433020542	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
479433020543	putative active site [active]
479433020544	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
479433020545	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
479433020546	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
479433020547	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
479433020548	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
479433020549	ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525
479433020550	Ligand binding site; other site
479433020551	Uncharacterized conserved protein [Function unknown]; Region: COG3603
479433020552	Family description; Region: ACT_7; pfam13840
479433020553	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
479433020554	RibD C-terminal domain; Region: RibD_C; cl17279
479433020555	RNA polymerase factor sigma-70; Validated; Region: PRK08241
479433020556	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433020557	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433020558	DNA binding residues [nucleotide binding]
479433020559	SnoaL-like domain; Region: SnoaL_2; pfam12680
479433020560	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
479433020561	glutaminase; Provisional; Region: PRK00971
479433020562	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433020563	Histidine kinase; Region: HisKA_3; pfam07730
479433020564	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433020565	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433020566	active site
479433020567	phosphorylation site [posttranslational modification]
479433020568	intermolecular recognition site; other site
479433020569	dimerization interface [polypeptide binding]; other site
479433020570	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433020571	DNA binding residues [nucleotide binding]
479433020572	dimerization interface [polypeptide binding]; other site
479433020573	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
479433020574	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
479433020575	Walker A/P-loop; other site
479433020576	ATP binding site [chemical binding]; other site
479433020577	Q-loop/lid; other site
479433020578	ABC transporter signature motif; other site
479433020579	Walker B; other site
479433020580	D-loop; other site
479433020581	H-loop/switch region; other site
479433020582	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
479433020583	active site
479433020584	PBP superfamily domain; Region: PBP_like_2; cl17296
479433020585	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
479433020586	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433020587	dimer interface [polypeptide binding]; other site
479433020588	conserved gate region; other site
479433020589	putative PBP binding loops; other site
479433020590	ABC-ATPase subunit interface; other site
479433020591	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
479433020592	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433020593	dimer interface [polypeptide binding]; other site
479433020594	conserved gate region; other site
479433020595	putative PBP binding loops; other site
479433020596	ABC-ATPase subunit interface; other site
479433020597	PBP superfamily domain; Region: PBP_like_2; cl17296
479433020598	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
479433020599	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
479433020600	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
479433020601	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
479433020602	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
479433020603	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
479433020604	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
479433020605	dimer interface [polypeptide binding]; other site
479433020606	PYR/PP interface [polypeptide binding]; other site
479433020607	TPP binding site [chemical binding]; other site
479433020608	substrate binding site [chemical binding]; other site
479433020609	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
479433020610	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
479433020611	TPP-binding site [chemical binding]; other site
479433020612	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
479433020613	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
479433020614	ssDNA binding site; other site
479433020615	generic binding surface II; other site
479433020616	Predicted permeases [General function prediction only]; Region: RarD; COG2962
479433020617	MarR family; Region: MarR_2; pfam12802
479433020618	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433020619	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
479433020620	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
479433020621	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
479433020622	substrate binding pocket [chemical binding]; other site
479433020623	chain length determination region; other site
479433020624	substrate-Mg2+ binding site; other site
479433020625	catalytic residues [active]
479433020626	aspartate-rich region 1; other site
479433020627	active site lid residues [active]
479433020628	aspartate-rich region 2; other site
479433020629	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
479433020630	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
479433020631	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
479433020632	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
479433020633	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
479433020634	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
479433020635	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
479433020636	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
479433020637	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
479433020638	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
479433020639	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
479433020640	4Fe-4S binding domain; Region: Fer4; pfam00037
479433020641	4Fe-4S binding domain; Region: Fer4; pfam00037
479433020642	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
479433020643	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
479433020644	NADH dehydrogenase subunit G; Validated; Region: PRK07860
479433020645	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
479433020646	catalytic loop [active]
479433020647	iron binding site [ion binding]; other site
479433020648	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
479433020649	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
479433020650	molybdopterin cofactor binding site; other site
479433020651	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
479433020652	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
479433020653	SLBB domain; Region: SLBB; pfam10531
479433020654	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
479433020655	NADH dehydrogenase subunit E; Validated; Region: PRK07539
479433020656	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
479433020657	putative dimer interface [polypeptide binding]; other site
479433020658	[2Fe-2S] cluster binding site [ion binding]; other site
479433020659	NADH dehydrogenase subunit D; Validated; Region: PRK06075
479433020660	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
479433020661	NADH dehydrogenase subunit C; Provisional; Region: PRK07785
479433020662	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
479433020663	NADH dehydrogenase subunit B; Validated; Region: PRK06411
479433020664	NADH dehydrogenase subunit A; Validated; Region: PRK07928
479433020665	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
479433020666	Leucine-rich repeats; other site
479433020667	Substrate binding site [chemical binding]; other site
479433020668	Leucine rich repeat; Region: LRR_8; pfam13855
479433020669	Leucine rich repeat; Region: LRR_8; pfam13855
479433020670	Leucine rich repeat; Region: LRR_8; pfam13855
479433020671	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
479433020672	Leucine-rich repeats; other site
479433020673	Leucine rich repeat; Region: LRR_8; pfam13855
479433020674	Substrate binding site [chemical binding]; other site
479433020675	Leucine rich repeat; Region: LRR_8; pfam13855
479433020676	Leucine rich repeat; Region: LRR_8; pfam13855
479433020677	Leucine rich repeat; Region: LRR_8; pfam13855
479433020678	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
479433020679	putative active site [active]
479433020680	putative substrate binding site [chemical binding]; other site
479433020681	ATP binding site [chemical binding]; other site
479433020682	Phosphotransferase enzyme family; Region: APH; pfam01636
479433020683	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
479433020684	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433020685	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433020686	N-acetyltransferase; Region: Acetyltransf_2; cl00949
479433020687	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
479433020688	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
479433020689	Eukaryotic phosphomannomutase; Region: PMM; cl17107
479433020690	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
479433020691	Malic enzyme, N-terminal domain; Region: malic; pfam00390
479433020692	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
479433020693	NAD(P) binding pocket [chemical binding]; other site
479433020694	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
479433020695	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
479433020696	substrate binding pocket [chemical binding]; other site
479433020697	membrane-bound complex binding site; other site
479433020698	hinge residues; other site
479433020699	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
479433020700	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433020701	dimer interface [polypeptide binding]; other site
479433020702	conserved gate region; other site
479433020703	putative PBP binding loops; other site
479433020704	ABC-ATPase subunit interface; other site
479433020705	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
479433020706	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
479433020707	Walker A/P-loop; other site
479433020708	ATP binding site [chemical binding]; other site
479433020709	Q-loop/lid; other site
479433020710	ABC transporter signature motif; other site
479433020711	Walker B; other site
479433020712	D-loop; other site
479433020713	H-loop/switch region; other site
479433020714	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
479433020715	CGNR zinc finger; Region: zf-CGNR; pfam11706
479433020716	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
479433020717	Catalytic site [active]
479433020718	Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055
479433020719	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
479433020720	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
479433020721	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433020722	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
479433020723	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433020724	DNA binding residues [nucleotide binding]
479433020725	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
479433020726	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
479433020727	Transcription factor WhiB; Region: Whib; pfam02467
479433020728	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
479433020729	PAS fold; Region: PAS_4; pfam08448
479433020730	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
479433020731	putative active site [active]
479433020732	heme pocket [chemical binding]; other site
479433020733	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
479433020734	Histidine kinase; Region: HisKA_2; pfam07568
479433020735	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433020736	ATP binding site [chemical binding]; other site
479433020737	Mg2+ binding site [ion binding]; other site
479433020738	G-X-G motif; other site
479433020739	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
479433020740	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433020741	catalytic residue [active]
479433020742	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
479433020743	Amidohydrolase; Region: Amidohydro_4; pfam13147
479433020744	active site
479433020745	dimer interface [polypeptide binding]; other site
479433020746	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
479433020747	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433020748	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433020749	DNA binding residues [nucleotide binding]
479433020750	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
479433020751	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
479433020752	dimer interface [polypeptide binding]; other site
479433020753	active site
479433020754	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
479433020755	dimer interface [polypeptide binding]; other site
479433020756	active site
479433020757	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
479433020758	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
479433020759	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433020760	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433020761	dimer interface [polypeptide binding]; other site
479433020762	conserved gate region; other site
479433020763	putative PBP binding loops; other site
479433020764	ABC-ATPase subunit interface; other site
479433020765	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433020766	dimer interface [polypeptide binding]; other site
479433020767	conserved gate region; other site
479433020768	putative PBP binding loops; other site
479433020769	ABC-ATPase subunit interface; other site
479433020770	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433020771	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433020772	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
479433020773	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433020774	DNA-binding site [nucleotide binding]; DNA binding site
479433020775	UTRA domain; Region: UTRA; pfam07702
479433020776	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
479433020777	AAA domain; Region: AAA_26; pfam13500
479433020778	biotin synthase; Validated; Region: PRK06256
479433020779	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433020780	FeS/SAM binding site; other site
479433020781	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
479433020782	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433020783	salt bridge; other site
479433020784	non-specific DNA binding site [nucleotide binding]; other site
479433020785	sequence-specific DNA binding site [nucleotide binding]; other site
479433020786	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433020787	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433020788	active site
479433020789	catalytic tetrad [active]
479433020790	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433020791	Coenzyme A binding pocket [chemical binding]; other site
479433020792	hypothetical protein; Provisional; Region: PRK05858
479433020793	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
479433020794	PYR/PP interface [polypeptide binding]; other site
479433020795	dimer interface [polypeptide binding]; other site
479433020796	TPP binding site [chemical binding]; other site
479433020797	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
479433020798	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
479433020799	TPP-binding site; other site
479433020800	dimer interface [polypeptide binding]; other site
479433020801	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433020802	S-adenosylmethionine binding site [chemical binding]; other site
479433020803	Predicted thioesterase [General function prediction only]; Region: COG5496
479433020804	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
479433020805	carboxyltransferase (CT) interaction site; other site
479433020806	biotinylation site [posttranslational modification]; other site
479433020807	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
479433020808	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
479433020809	Zn2+ binding site [ion binding]; other site
479433020810	Mg2+ binding site [ion binding]; other site
479433020811	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
479433020812	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
479433020813	Zn2+ binding site [ion binding]; other site
479433020814	Mg2+ binding site [ion binding]; other site
479433020815	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988
479433020816	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
479433020817	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433020818	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433020819	DNA binding residues [nucleotide binding]
479433020820	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
479433020821	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
479433020822	active site
479433020823	Riboflavin kinase; Region: Flavokinase; smart00904
479433020824	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
479433020825	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
479433020826	RNA binding site [nucleotide binding]; other site
479433020827	active site
479433020828	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
479433020829	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
479433020830	Protein of unknown function (DUF503); Region: DUF503; pfam04456
479433020831	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
479433020832	translation initiation factor IF-2; Region: IF-2; TIGR00487
479433020833	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
479433020834	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
479433020835	G1 box; other site
479433020836	putative GEF interaction site [polypeptide binding]; other site
479433020837	GTP/Mg2+ binding site [chemical binding]; other site
479433020838	Switch I region; other site
479433020839	G2 box; other site
479433020840	G3 box; other site
479433020841	Switch II region; other site
479433020842	G4 box; other site
479433020843	G5 box; other site
479433020844	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
479433020845	Translation-initiation factor 2; Region: IF-2; pfam11987
479433020846	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
479433020847	Protein of unknown function (DUF448); Region: DUF448; pfam04296
479433020848	putative RNA binding cleft [nucleotide binding]; other site
479433020849	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433020850	dimerization interface [polypeptide binding]; other site
479433020851	putative DNA binding site [nucleotide binding]; other site
479433020852	putative Zn2+ binding site [ion binding]; other site
479433020853	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
479433020854	hydrophobic ligand binding site; other site
479433020855	RibD C-terminal domain; Region: RibD_C; cl17279
479433020856	Helix-turn-helix domain; Region: HTH_31; pfam13560
479433020857	salt bridge; other site
479433020858	non-specific DNA binding site [nucleotide binding]; other site
479433020859	sequence-specific DNA binding site [nucleotide binding]; other site
479433020860	Domain of unknown function (DUF336); Region: DUF336; pfam03928
479433020861	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
479433020862	NusA N-terminal domain; Region: NusA_N; pfam08529
479433020863	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
479433020864	RNA binding site [nucleotide binding]; other site
479433020865	homodimer interface [polypeptide binding]; other site
479433020866	NusA-like KH domain; Region: KH_5; pfam13184
479433020867	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
479433020868	G-X-X-G motif; other site
479433020869	ribosome maturation protein RimP; Reviewed; Region: PRK00092
479433020870	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
479433020871	putative oligomer interface [polypeptide binding]; other site
479433020872	putative RNA binding site [nucleotide binding]; other site
479433020873	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
479433020874	dinuclear metal binding motif [ion binding]; other site
479433020875	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433020876	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433020877	active site
479433020878	ATP binding site [chemical binding]; other site
479433020879	substrate binding site [chemical binding]; other site
479433020880	activation loop (A-loop); other site
479433020881	prolyl-tRNA synthetase; Provisional; Region: PRK09194
479433020882	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
479433020883	dimer interface [polypeptide binding]; other site
479433020884	motif 1; other site
479433020885	active site
479433020886	motif 2; other site
479433020887	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
479433020888	putative deacylase active site [active]
479433020889	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
479433020890	active site
479433020891	motif 3; other site
479433020892	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
479433020893	anticodon binding site; other site
479433020894	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
479433020895	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
479433020896	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433020897	AlkA N-terminal domain; Region: AlkA_N; pfam06029
479433020898	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
479433020899	minor groove reading motif; other site
479433020900	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
479433020901	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
479433020902	helix-hairpin-helix signature motif; other site
479433020903	substrate binding pocket [chemical binding]; other site
479433020904	active site
479433020905	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
479433020906	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
479433020907	DNA binding site [nucleotide binding]
479433020908	active site
479433020909	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
479433020910	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433020911	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
479433020912	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
479433020913	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
479433020914	RIP metalloprotease RseP; Region: TIGR00054
479433020915	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
479433020916	active site
479433020917	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
479433020918	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
479433020919	putative substrate binding region [chemical binding]; other site
479433020920	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
479433020921	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
479433020922	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
479433020923	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
479433020924	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
479433020925	putative active site [active]
479433020926	putative catalytic site [active]
479433020927	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
479433020928	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433020929	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433020930	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433020931	active site
479433020932	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
479433020933	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
479433020934	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
479433020935	EamA-like transporter family; Region: EamA; pfam00892
479433020936	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
479433020937	adenosine deaminase; Provisional; Region: PRK09358
479433020938	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
479433020939	active site
479433020940	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
479433020941	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433020942	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
479433020943	Walker A/P-loop; other site
479433020944	ATP binding site [chemical binding]; other site
479433020945	Q-loop/lid; other site
479433020946	ABC transporter signature motif; other site
479433020947	Walker B; other site
479433020948	D-loop; other site
479433020949	H-loop/switch region; other site
479433020950	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
479433020951	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
479433020952	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433020953	Walker A/P-loop; other site
479433020954	ATP binding site [chemical binding]; other site
479433020955	Q-loop/lid; other site
479433020956	ABC transporter signature motif; other site
479433020957	Walker B; other site
479433020958	D-loop; other site
479433020959	H-loop/switch region; other site
479433020960	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
479433020961	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
479433020962	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433020963	dimer interface [polypeptide binding]; other site
479433020964	conserved gate region; other site
479433020965	putative PBP binding loops; other site
479433020966	ABC-ATPase subunit interface; other site
479433020967	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
479433020968	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433020969	dimer interface [polypeptide binding]; other site
479433020970	conserved gate region; other site
479433020971	putative PBP binding loops; other site
479433020972	ABC-ATPase subunit interface; other site
479433020973	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
479433020974	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
479433020975	ketol-acid reductoisomerase; Provisional; Region: PRK05479
479433020976	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
479433020977	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
479433020978	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
479433020979	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
479433020980	putative valine binding site [chemical binding]; other site
479433020981	dimer interface [polypeptide binding]; other site
479433020982	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
479433020983	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
479433020984	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
479433020985	PYR/PP interface [polypeptide binding]; other site
479433020986	dimer interface [polypeptide binding]; other site
479433020987	TPP binding site [chemical binding]; other site
479433020988	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
479433020989	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
479433020990	TPP-binding site [chemical binding]; other site
479433020991	dimer interface [polypeptide binding]; other site
479433020992	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
479433020993	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
479433020994	metal binding site [ion binding]; metal-binding site
479433020995	active site
479433020996	I-site; other site
479433020997	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
479433020998	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
479433020999	active site
479433021000	catalytic residues [active]
479433021001	metal binding site [ion binding]; metal-binding site
479433021002	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
479433021003	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433021004	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
479433021005	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
479433021006	homodimer interface [polypeptide binding]; other site
479433021007	substrate-cofactor binding pocket; other site
479433021008	catalytic residue [active]
479433021009	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
479433021010	tartrate dehydrogenase; Region: TTC; TIGR02089
479433021011	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433021012	S-adenosylmethionine binding site [chemical binding]; other site
479433021013	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
479433021014	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
479433021015	ligand binding site [chemical binding]; other site
479433021016	NAD binding site [chemical binding]; other site
479433021017	dimerization interface [polypeptide binding]; other site
479433021018	catalytic site [active]
479433021019	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
479433021020	putative L-serine binding site [chemical binding]; other site
479433021021	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
479433021022	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
479433021023	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
479433021024	Walker A motif; other site
479433021025	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
479433021026	active site
479433021027	ATP binding site [chemical binding]; other site
479433021028	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
479433021029	Transcription factor WhiB; Region: Whib; pfam02467
479433021030	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
479433021031	Part of AAA domain; Region: AAA_19; pfam13245
479433021032	Family description; Region: UvrD_C_2; pfam13538
479433021033	HRDC domain; Region: HRDC; pfam00570
479433021034	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
479433021035	catalytic residues [active]
479433021036	Glypican; Region: Glypican; pfam01153
479433021037	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
479433021038	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
479433021039	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
479433021040	putative NADH binding site [chemical binding]; other site
479433021041	putative active site [active]
479433021042	nudix motif; other site
479433021043	putative metal binding site [ion binding]; other site
479433021044	hypothetical protein; Provisional; Region: PRK08201
479433021045	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
479433021046	metal binding site [ion binding]; metal-binding site
479433021047	putative dimer interface [polypeptide binding]; other site
479433021048	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
479433021049	dimer interface [polypeptide binding]; other site
479433021050	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
479433021051	NADP binding site [chemical binding]; other site
479433021052	catalytic residues [active]
479433021053	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433021054	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433021055	AAA domain; Region: AAA_30; pfam13604
479433021056	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
479433021057	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
479433021058	Family description; Region: UvrD_C_2; pfam13538
479433021059	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
479433021060	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
479433021061	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
479433021062	Family description; Region: UvrD_C_2; pfam13538
479433021063	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
479433021064	FtsX-like permease family; Region: FtsX; pfam02687
479433021065	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
479433021066	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
479433021067	FtsX-like permease family; Region: FtsX; pfam02687
479433021068	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
479433021069	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
479433021070	Walker A/P-loop; other site
479433021071	ATP binding site [chemical binding]; other site
479433021072	Q-loop/lid; other site
479433021073	ABC transporter signature motif; other site
479433021074	Walker B; other site
479433021075	D-loop; other site
479433021076	H-loop/switch region; other site
479433021077	Histidine kinase; Region: HisKA_3; pfam07730
479433021078	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433021079	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433021080	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433021081	active site
479433021082	phosphorylation site [posttranslational modification]
479433021083	intermolecular recognition site; other site
479433021084	dimerization interface [polypeptide binding]; other site
479433021085	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433021086	DNA binding residues [nucleotide binding]
479433021087	dimerization interface [polypeptide binding]; other site
479433021088	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
479433021089	DNA binding site [nucleotide binding]
479433021090	active site
479433021091	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cl01321
479433021092	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
479433021093	active site
479433021094	ATP binding site [chemical binding]; other site
479433021095	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
479433021096	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
479433021097	ATP binding site [chemical binding]; other site
479433021098	substrate interface [chemical binding]; other site
479433021099	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
479433021100	active site residue [active]
479433021101	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433021102	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433021103	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
479433021104	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
479433021105	dinuclear metal binding motif [ion binding]; other site
479433021106	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
479433021107	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
479433021108	ATP binding site [chemical binding]; other site
479433021109	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
479433021110	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
479433021111	putative Mg++ binding site [ion binding]; other site
479433021112	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
479433021113	nucleotide binding region [chemical binding]; other site
479433021114	ATP-binding site [chemical binding]; other site
479433021115	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
479433021116	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433021117	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
479433021118	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
479433021119	active site
479433021120	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
479433021121	short chain dehydrogenase; Provisional; Region: PRK06172
479433021122	classical (c) SDRs; Region: SDR_c; cd05233
479433021123	NAD(P) binding site [chemical binding]; other site
479433021124	active site
479433021125	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
479433021126	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433021127	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
479433021128	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
479433021129	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433021130	NAD(P) binding site [chemical binding]; other site
479433021131	active site
479433021132	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
479433021133	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
479433021134	NAD(P) binding site [chemical binding]; other site
479433021135	catalytic residues [active]
479433021136	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
479433021137	active site
479433021138	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
479433021139	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
479433021140	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
479433021141	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
479433021142	Na binding site [ion binding]; other site
479433021143	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
479433021144	active site
479433021145	ATP binding site [chemical binding]; other site
479433021146	substrate binding site [chemical binding]; other site
479433021147	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433021148	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433021149	putative substrate translocation pore; other site
479433021150	tetracycline repressor protein TetR; Provisional; Region: PRK13756
479433021151	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433021152	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
479433021153	Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426
479433021154	polypeptide substrate binding site [polypeptide binding]; other site
479433021155	active site
479433021156	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
479433021157	Domain of unknown function DUF87; Region: DUF87; pfam01935
479433021158	AAA-like domain; Region: AAA_10; pfam12846
479433021159	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
479433021160	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
479433021161	inhibitor-cofactor binding pocket; inhibition site
479433021162	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433021163	catalytic residue [active]
479433021164	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
479433021165	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
479433021166	Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829
479433021167	active site
479433021168	putative catalytic site [active]
479433021169	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433021170	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433021171	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
479433021172	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433021173	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433021174	Walker A/P-loop; other site
479433021175	ATP binding site [chemical binding]; other site
479433021176	Q-loop/lid; other site
479433021177	ABC transporter signature motif; other site
479433021178	Walker B; other site
479433021179	D-loop; other site
479433021180	H-loop/switch region; other site
479433021181	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433021182	Histidine kinase; Region: HisKA_3; pfam07730
479433021183	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433021184	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433021185	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433021186	active site
479433021187	phosphorylation site [posttranslational modification]
479433021188	intermolecular recognition site; other site
479433021189	dimerization interface [polypeptide binding]; other site
479433021190	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433021191	DNA binding residues [nucleotide binding]
479433021192	dimerization interface [polypeptide binding]; other site
479433021193	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
479433021194	classical (c) SDRs; Region: SDR_c; cd05233
479433021195	NAD(P) binding site [chemical binding]; other site
479433021196	active site
479433021197	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
479433021198	active site
479433021199	Competence-damaged protein; Region: CinA; pfam02464
479433021200	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
479433021201	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
479433021202	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
479433021203	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433021204	FeS/SAM binding site; other site
479433021205	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433021206	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433021207	putative substrate translocation pore; other site
479433021208	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433021209	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433021210	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433021211	putative DNA binding site [nucleotide binding]; other site
479433021212	dimerization interface [polypeptide binding]; other site
479433021213	putative Zn2+ binding site [ion binding]; other site
479433021214	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
479433021215	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
479433021216	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
479433021217	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
479433021218	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
479433021219	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
479433021220	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
479433021221	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
479433021222	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
479433021223	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
479433021224	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
479433021225	dimer interface [polypeptide binding]; other site
479433021226	active site
479433021227	catalytic residue [active]
479433021228	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
479433021229	NMT1/THI5 like; Region: NMT1; pfam09084
479433021230	Nitrate and nitrite sensing; Region: NIT; pfam08376
479433021231	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433021232	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
479433021233	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433021234	ATP binding site [chemical binding]; other site
479433021235	Mg2+ binding site [ion binding]; other site
479433021236	G-X-G motif; other site
479433021237	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
479433021238	Protein of unknown function (DUF742); Region: DUF742; pfam05331
479433021239	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
479433021240	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
479433021241	G2 box; other site
479433021242	Switch I region; other site
479433021243	G3 box; other site
479433021244	Switch II region; other site
479433021245	G4 box; other site
479433021246	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
479433021247	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433021248	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433021249	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
479433021250	putative dimerization interface [polypeptide binding]; other site
479433021251	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
479433021252	homotrimer interaction site [polypeptide binding]; other site
479433021253	putative active site [active]
479433021254	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
479433021255	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
479433021256	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
479433021257	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433021258	TPR repeat; Region: TPR_11; pfam13414
479433021259	TPR motif; other site
479433021260	dihydrodipicolinate reductase; Provisional; Region: PRK00048
479433021261	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
479433021262	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
479433021263	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
479433021264	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
479433021265	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
479433021266	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
479433021267	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
479433021268	oligomer interface [polypeptide binding]; other site
479433021269	RNA binding site [nucleotide binding]; other site
479433021270	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
479433021271	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
479433021272	RNase E interface [polypeptide binding]; other site
479433021273	trimer interface [polypeptide binding]; other site
479433021274	active site
479433021275	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
479433021276	putative nucleic acid binding region [nucleotide binding]; other site
479433021277	G-X-X-G motif; other site
479433021278	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
479433021279	RNA binding site [nucleotide binding]; other site
479433021280	domain interface; other site
479433021281	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
479433021282	16S/18S rRNA binding site [nucleotide binding]; other site
479433021283	S13e-L30e interaction site [polypeptide binding]; other site
479433021284	25S rRNA binding site [nucleotide binding]; other site
479433021285	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
479433021286	active site
479433021287	catalytic residues [active]
479433021288	Domain of unknown function (DUF222); Region: DUF222; pfam02720
479433021289	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
479433021290	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
479433021291	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
479433021292	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
479433021293	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
479433021294	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
479433021295	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
479433021296	Protein of unknown function (DUF690); Region: DUF690; cl04939
479433021297	hypothetical protein; Provisional; Region: PRK07906
479433021298	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
479433021299	putative metal binding site [ion binding]; other site
479433021300	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
479433021301	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
479433021302	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
479433021303	hinge; other site
479433021304	active site
479433021305	Predicted GTPases [General function prediction only]; Region: COG1162
479433021306	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
479433021307	GTPase/Zn-binding domain interface [polypeptide binding]; other site
479433021308	GTP/Mg2+ binding site [chemical binding]; other site
479433021309	G4 box; other site
479433021310	G5 box; other site
479433021311	G1 box; other site
479433021312	Switch I region; other site
479433021313	G2 box; other site
479433021314	G3 box; other site
479433021315	Switch II region; other site
479433021316	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
479433021317	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
479433021318	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433021319	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
479433021320	FtsX-like permease family; Region: FtsX; pfam02687
479433021321	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
479433021322	FtsX-like permease family; Region: FtsX; pfam02687
479433021323	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
479433021324	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
479433021325	Walker A/P-loop; other site
479433021326	ATP binding site [chemical binding]; other site
479433021327	Q-loop/lid; other site
479433021328	ABC transporter signature motif; other site
479433021329	Walker B; other site
479433021330	D-loop; other site
479433021331	H-loop/switch region; other site
479433021332	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
479433021333	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433021334	MarR family; Region: MarR_2; pfam12802
479433021335	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
479433021336	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
479433021337	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
479433021338	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
479433021339	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
479433021340	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433021341	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433021342	dimer interface [polypeptide binding]; other site
479433021343	conserved gate region; other site
479433021344	putative PBP binding loops; other site
479433021345	ABC-ATPase subunit interface; other site
479433021346	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433021347	dimer interface [polypeptide binding]; other site
479433021348	conserved gate region; other site
479433021349	ABC-ATPase subunit interface; other site
479433021350	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433021351	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433021352	MarR family; Region: MarR_2; cl17246
479433021353	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
479433021354	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
479433021355	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
479433021356	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
479433021357	TM-ABC transporter signature motif; other site
479433021358	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
479433021359	TM-ABC transporter signature motif; other site
479433021360	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
479433021361	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
479433021362	Walker A/P-loop; other site
479433021363	ATP binding site [chemical binding]; other site
479433021364	Q-loop/lid; other site
479433021365	ABC transporter signature motif; other site
479433021366	Walker B; other site
479433021367	D-loop; other site
479433021368	H-loop/switch region; other site
479433021369	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
479433021370	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
479433021371	Walker A/P-loop; other site
479433021372	ATP binding site [chemical binding]; other site
479433021373	Q-loop/lid; other site
479433021374	ABC transporter signature motif; other site
479433021375	Walker B; other site
479433021376	D-loop; other site
479433021377	H-loop/switch region; other site
479433021378	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
479433021379	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
479433021380	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
479433021381	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
479433021382	GAF domain; Region: GAF; pfam01590
479433021383	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
479433021384	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433021385	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
479433021386	NAD(P) binding site [chemical binding]; other site
479433021387	active site
479433021388	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
479433021389	alpha-galactosidase; Region: PLN02808; cl17638
479433021390	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433021391	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433021392	putative sugar binding sites [chemical binding]; other site
479433021393	Q-X-W motif; other site
479433021394	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
479433021395	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
479433021396	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
479433021397	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433021398	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433021399	dimer interface [polypeptide binding]; other site
479433021400	conserved gate region; other site
479433021401	putative PBP binding loops; other site
479433021402	ABC-ATPase subunit interface; other site
479433021403	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
479433021404	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433021405	dimer interface [polypeptide binding]; other site
479433021406	conserved gate region; other site
479433021407	putative PBP binding loops; other site
479433021408	ABC-ATPase subunit interface; other site
479433021409	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
479433021410	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433021411	PknH-like extracellular domain; Region: PknH_C; pfam14032
479433021412	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
479433021413	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
479433021414	Walker A/P-loop; other site
479433021415	ATP binding site [chemical binding]; other site
479433021416	Q-loop/lid; other site
479433021417	ABC transporter signature motif; other site
479433021418	Walker B; other site
479433021419	D-loop; other site
479433021420	H-loop/switch region; other site
479433021421	Predicted transcriptional regulators [Transcription]; Region: COG1695
479433021422	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
479433021423	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
479433021424	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
479433021425	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
479433021426	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
479433021427	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
479433021428	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
479433021429	MoaE homodimer interface [polypeptide binding]; other site
479433021430	MoaD interaction [polypeptide binding]; other site
479433021431	active site residues [active]
479433021432	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
479433021433	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
479433021434	putative NAD(P) binding site [chemical binding]; other site
479433021435	active site
479433021436	putative substrate binding site [chemical binding]; other site
479433021437	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
479433021438	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
479433021439	Protein of unknown function DUF45; Region: DUF45; pfam01863
479433021440	enoyl-CoA hydratase; Provisional; Region: PRK06688
479433021441	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
479433021442	substrate binding site [chemical binding]; other site
479433021443	oxyanion hole (OAH) forming residues; other site
479433021444	trimer interface [polypeptide binding]; other site
479433021445	sec-independent translocase; Provisional; Region: PRK01371
479433021446	Putative zinc-finger; Region: zf-HC2; pfam13490
479433021447	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
479433021448	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433021449	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433021450	DNA binding residues [nucleotide binding]
479433021451	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
479433021452	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433021453	S-adenosylmethionine binding site [chemical binding]; other site
479433021454	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
479433021455	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
479433021456	enoyl-CoA hydratase; Provisional; Region: PRK08140
479433021457	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
479433021458	substrate binding site [chemical binding]; other site
479433021459	oxyanion hole (OAH) forming residues; other site
479433021460	trimer interface [polypeptide binding]; other site
479433021461	DivIVA domain; Region: DivI1A_domain; TIGR03544
479433021462	dihydropteroate synthase; Region: DHPS; TIGR01496
479433021463	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
479433021464	substrate binding pocket [chemical binding]; other site
479433021465	dimer interface [polypeptide binding]; other site
479433021466	inhibitor binding site; inhibition site
479433021467	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
479433021468	Predicted esterase [General function prediction only]; Region: COG0627
479433021469	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
479433021470	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
479433021471	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
479433021472	metal binding site [ion binding]; metal-binding site
479433021473	putative dimer interface [polypeptide binding]; other site
479433021474	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
479433021475	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
479433021476	trimer interface [polypeptide binding]; other site
479433021477	active site
479433021478	substrate binding site [chemical binding]; other site
479433021479	CoA binding site [chemical binding]; other site
479433021480	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
479433021481	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
479433021482	radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269
479433021483	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433021484	FeS/SAM binding site; other site
479433021485	HEXXH motif domain; Region: mod_HExxH; TIGR04267
479433021486	TIR domain; Region: TIR_2; pfam13676
479433021487	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
479433021488	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
479433021489	P-loop; other site
479433021490	Magnesium ion binding site [ion binding]; other site
479433021491	TIR domain; Region: TIR_2; cl17458
479433021492	NB-ARC domain; Region: NB-ARC; pfam00931
479433021493	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433021494	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433021495	Tetratricopeptide repeat; Region: TPR_10; pfam13374
479433021496	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433021497	Tetratricopeptide repeat; Region: TPR_10; pfam13374
479433021498	Tetratricopeptide repeat; Region: TPR_10; pfam13374
479433021499	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
479433021500	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433021501	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433021502	DNA binding residues [nucleotide binding]
479433021503	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433021504	NADH(P)-binding; Region: NAD_binding_10; pfam13460
479433021505	NAD(P) binding site [chemical binding]; other site
479433021506	active site
479433021507	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433021508	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
479433021509	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
479433021510	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
479433021511	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433021512	homodimer interface [polypeptide binding]; other site
479433021513	catalytic residue [active]
479433021514	Ferredoxin [Energy production and conversion]; Region: COG1146
479433021515	4Fe-4S binding domain; Region: Fer4; pfam00037
479433021516	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
479433021517	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
479433021518	active site
479433021519	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433021520	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433021521	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433021522	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433021523	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433021524	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
479433021525	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
479433021526	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
479433021527	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
479433021528	active site
479433021529	HIGH motif; other site
479433021530	dimer interface [polypeptide binding]; other site
479433021531	KMSKS motif; other site
479433021532	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
479433021533	Domain of unknown function DUF21; Region: DUF21; pfam01595
479433021534	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
479433021535	Transporter associated domain; Region: CorC_HlyC; pfam03471
479433021536	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
479433021537	Amidinotransferase; Region: Amidinotransf; cl12043
479433021538	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
479433021539	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
479433021540	inhibitor-cofactor binding pocket; inhibition site
479433021541	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433021542	catalytic residue [active]
479433021543	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
479433021544	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
479433021545	AsnC family; Region: AsnC_trans_reg; pfam01037
479433021546	malate dehydrogenase; Provisional; Region: PRK05442
479433021547	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
479433021548	NAD(P) binding site [chemical binding]; other site
479433021549	dimer interface [polypeptide binding]; other site
479433021550	malate binding site [chemical binding]; other site
479433021551	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
479433021552	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433021553	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
479433021554	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
479433021555	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
479433021556	metal binding site [ion binding]; metal-binding site
479433021557	dimer interface [polypeptide binding]; other site
479433021558	isocitrate dehydrogenase; Validated; Region: PRK08299
479433021559	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
479433021560	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
479433021561	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
479433021562	homodimer interface [polypeptide binding]; other site
479433021563	NADP binding site [chemical binding]; other site
479433021564	substrate binding site [chemical binding]; other site
479433021565	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
479433021566	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
479433021567	purine monophosphate binding site [chemical binding]; other site
479433021568	dimer interface [polypeptide binding]; other site
479433021569	putative catalytic residues [active]
479433021570	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
479433021571	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
479433021572	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
479433021573	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
479433021574	active site
479433021575	substrate binding site [chemical binding]; other site
479433021576	cosubstrate binding site; other site
479433021577	catalytic site [active]
479433021578	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
479433021579	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433021580	putative DNA binding site [nucleotide binding]; other site
479433021581	putative Zn2+ binding site [ion binding]; other site
479433021582	AsnC family; Region: AsnC_trans_reg; pfam01037
479433021583	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
479433021584	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
479433021585	CoA binding domain; Region: CoA_binding; smart00881
479433021586	CoA-ligase; Region: Ligase_CoA; pfam00549
479433021587	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
479433021588	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
479433021589	CoA-ligase; Region: Ligase_CoA; pfam00549
479433021590	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
479433021591	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
479433021592	Zn binding site [ion binding]; other site
479433021593	Flagellar protein (FlbD); Region: FlbD; cl00683
479433021594	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
479433021595	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
479433021596	metal ion-dependent adhesion site (MIDAS); other site
479433021597	MoxR-like ATPases [General function prediction only]; Region: COG0714
479433021598	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
479433021599	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
479433021600	B12 binding site [chemical binding]; other site
479433021601	cobalt ligand [ion binding]; other site
479433021602	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
479433021603	Peptidase family M23; Region: Peptidase_M23; pfam01551
479433021604	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
479433021605	Part of AAA domain; Region: AAA_19; pfam13245
479433021606	Family description; Region: UvrD_C_2; pfam13538
479433021607	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
479433021608	[Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693
479433021609	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
479433021610	metal binding triad; other site
479433021611	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
479433021612	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
479433021613	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
479433021614	Nitrogen regulatory protein P-II; Region: P-II; smart00938
479433021615	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
479433021616	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
479433021617	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
479433021618	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
479433021619	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
479433021620	OsmC-like protein; Region: OsmC; pfam02566
479433021621	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
479433021622	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
479433021623	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
479433021624	AAA domain; Region: AAA_23; pfam13476
479433021625	Walker A/P-loop; other site
479433021626	ATP binding site [chemical binding]; other site
479433021627	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
479433021628	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
479433021629	ABC transporter signature motif; other site
479433021630	Walker B; other site
479433021631	D-loop; other site
479433021632	H-loop/switch region; other site
479433021633	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
479433021634	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
479433021635	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
479433021636	hypothetical protein; Provisional; Region: PRK07208
479433021637	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
479433021638	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
479433021639	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
479433021640	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
479433021641	DNA binding site [nucleotide binding]
479433021642	catalytic residue [active]
479433021643	H2TH interface [polypeptide binding]; other site
479433021644	putative catalytic residues [active]
479433021645	turnover-facilitating residue; other site
479433021646	intercalation triad [nucleotide binding]; other site
479433021647	8OG recognition residue [nucleotide binding]; other site
479433021648	putative reading head residues; other site
479433021649	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
479433021650	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
479433021651	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
479433021652	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
479433021653	dimerization interface [polypeptide binding]; other site
479433021654	active site
479433021655	metal binding site [ion binding]; metal-binding site
479433021656	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
479433021657	dsRNA binding site [nucleotide binding]; other site
479433021658	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
479433021659	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
479433021660	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
479433021661	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
479433021662	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
479433021663	active site
479433021664	(T/H)XGH motif; other site
479433021665	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
479433021666	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433021667	S-adenosylmethionine binding site [chemical binding]; other site
479433021668	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
479433021669	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
479433021670	generic binding surface II; other site
479433021671	ssDNA binding site; other site
479433021672	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
479433021673	ATP binding site [chemical binding]; other site
479433021674	putative Mg++ binding site [ion binding]; other site
479433021675	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
479433021676	nucleotide binding region [chemical binding]; other site
479433021677	ATP-binding site [chemical binding]; other site
479433021678	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
479433021679	DAK2 domain; Region: Dak2; pfam02734
479433021680	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
479433021681	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
479433021682	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
479433021683	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
479433021684	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
479433021685	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
479433021686	putative active site [active]
479433021687	putative dimer interface [polypeptide binding]; other site
479433021688	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
479433021689	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
479433021690	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
479433021691	dimer interface [polypeptide binding]; other site
479433021692	substrate binding site [chemical binding]; other site
479433021693	ATP binding site [chemical binding]; other site
479433021694	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433021695	Coenzyme A binding pocket [chemical binding]; other site
479433021696	Transcriptional regulator [Transcription]; Region: LysR; COG0583
479433021697	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
479433021698	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
479433021699	dimerization interface [polypeptide binding]; other site
479433021700	YCII-related domain; Region: YCII; cl00999
479433021701	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
479433021702	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433021703	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433021704	thiamine monophosphate kinase; Provisional; Region: PRK05731
479433021705	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
479433021706	ATP binding site [chemical binding]; other site
479433021707	dimerization interface [polypeptide binding]; other site
479433021708	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
479433021709	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
479433021710	AsnC family; Region: AsnC_trans_reg; pfam01037
479433021711	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
479433021712	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
479433021713	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
479433021714	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
479433021715	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
479433021716	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
479433021717	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
479433021718	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
479433021719	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
479433021720	putative acyl-acceptor binding pocket; other site
479433021721	Guanylyl transferase CofC like; Region: CofC; cl17472
479433021722	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
479433021723	IHF dimer interface [polypeptide binding]; other site
479433021724	IHF - DNA interface [nucleotide binding]; other site
479433021725	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
479433021726	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
479433021727	substrate binding site [chemical binding]; other site
479433021728	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
479433021729	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
479433021730	substrate binding site [chemical binding]; other site
479433021731	ligand binding site [chemical binding]; other site
479433021732	Transcriptional regulator [Transcription]; Region: IclR; COG1414
479433021733	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
479433021734	Bacterial transcriptional regulator; Region: IclR; pfam01614
479433021735	PQQ-like domain; Region: PQQ_2; pfam13360
479433021736	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
479433021737	active site
479433021738	Trp docking motif [polypeptide binding]; other site
479433021739	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
479433021740	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
479433021741	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
479433021742	homodimer interface [polypeptide binding]; other site
479433021743	NADP binding site [chemical binding]; other site
479433021744	substrate binding site [chemical binding]; other site
479433021745	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
479433021746	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
479433021747	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
479433021748	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433021749	S-adenosylmethionine binding site [chemical binding]; other site
479433021750	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
479433021751	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
479433021752	active site
479433021753	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
479433021754	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
479433021755	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
479433021756	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433021757	acyl-activating enzyme (AAE) consensus motif; other site
479433021758	AMP binding site [chemical binding]; other site
479433021759	active site
479433021760	CoA binding site [chemical binding]; other site
479433021761	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
479433021762	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433021763	FeS/SAM binding site; other site
479433021764	Protein of unknown function (DUF1152); Region: DUF1152; pfam06626
479433021765	Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4034
479433021766	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
479433021767	CoenzymeA binding site [chemical binding]; other site
479433021768	subunit interaction site [polypeptide binding]; other site
479433021769	PHB binding site; other site
479433021770	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
479433021771	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
479433021772	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
479433021773	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433021774	Coenzyme A binding pocket [chemical binding]; other site
479433021775	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
479433021776	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433021777	FeS/SAM binding site; other site
479433021778	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
479433021779	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
479433021780	putative DNA binding site [nucleotide binding]; other site
479433021781	putative Zn2+ binding site [ion binding]; other site
479433021782	AsnC family; Region: AsnC_trans_reg; pfam01037
479433021783	Domain of unknown function (DUF3291); Region: DUF3291; pfam11695
479433021784	Flavoprotein; Region: Flavoprotein; pfam02441
479433021785	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
479433021786	prenyltransferase; Reviewed; Region: ubiA; PRK12888
479433021787	UbiA prenyltransferase family; Region: UbiA; pfam01040
479433021788	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
479433021789	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
479433021790	Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335
479433021791	Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082
479433021792	Ca binding site [ion binding]; other site
479433021793	Ca binding site (active) [ion binding]; other site
479433021794	ligand binding site [chemical binding]; other site
479433021795	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
479433021796	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
479433021797	ResB-like family; Region: ResB; pfam05140
479433021798	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
479433021799	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
479433021800	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
479433021801	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
479433021802	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
479433021803	catalytic residues [active]
479433021804	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
479433021805	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
479433021806	catalytic core [active]
479433021807	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
479433021808	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
479433021809	inhibitor-cofactor binding pocket; inhibition site
479433021810	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433021811	catalytic residue [active]
479433021812	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
479433021813	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433021814	hypothetical protein; Provisional; Region: PRK08236
479433021815	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
479433021816	prolyl-tRNA synthetase; Provisional; Region: PRK08661
479433021817	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
479433021818	dimer interface [polypeptide binding]; other site
479433021819	motif 1; other site
479433021820	active site
479433021821	motif 2; other site
479433021822	motif 3; other site
479433021823	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
479433021824	anticodon binding site; other site
479433021825	zinc-binding site [ion binding]; other site
479433021826	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
479433021827	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
479433021828	putative dimer interface [polypeptide binding]; other site
479433021829	putative [2Fe-2S] cluster binding site [ion binding]; other site
479433021830	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
479433021831	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
479433021832	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
479433021833	DNA-binding site [nucleotide binding]; DNA binding site
479433021834	RNA-binding motif; other site
479433021835	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
479433021836	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
479433021837	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433021838	catalytic residue [active]
479433021839	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
479433021840	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
479433021841	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433021842	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433021843	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433021844	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433021845	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
479433021846	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
479433021847	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
479433021848	active site
479433021849	D-galactonate transporter; Region: 2A0114; TIGR00893
479433021850	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433021851	putative substrate translocation pore; other site
479433021852	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
479433021853	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
479433021854	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
479433021855	ATP binding site [chemical binding]; other site
479433021856	putative Mg++ binding site [ion binding]; other site
479433021857	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
479433021858	nucleotide binding region [chemical binding]; other site
479433021859	ATP-binding site [chemical binding]; other site
479433021860	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
479433021861	Part of AAA domain; Region: AAA_19; pfam13245
479433021862	Family description; Region: UvrD_C_2; pfam13538
479433021863	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
479433021864	CutC family; Region: CutC; cl01218
479433021865	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
479433021866	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
479433021867	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
479433021868	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433021869	DNA-binding site [nucleotide binding]; DNA binding site
479433021870	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
479433021871	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
479433021872	active site turn [active]
479433021873	phosphorylation site [posttranslational modification]
479433021874	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
479433021875	HPr interaction site; other site
479433021876	glycerol kinase (GK) interaction site [polypeptide binding]; other site
479433021877	active site
479433021878	phosphorylation site [posttranslational modification]
479433021879	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
479433021880	dimerization domain swap beta strand [polypeptide binding]; other site
479433021881	regulatory protein interface [polypeptide binding]; other site
479433021882	active site
479433021883	regulatory phosphorylation site [posttranslational modification]; other site
479433021884	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
479433021885	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
479433021886	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
479433021887	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
479433021888	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
479433021889	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
479433021890	Protein of unknown function (DUF4031); Region: DUF4031; pfam13223
479433021891	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
479433021892	binding surface
479433021893	TPR motif; other site
479433021894	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433021895	Tetratricopeptide repeat; Region: TPR_12; pfam13424
479433021896	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
479433021897	putative active site [active]
479433021898	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
479433021899	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
479433021900	ring oligomerisation interface [polypeptide binding]; other site
479433021901	ATP/Mg binding site [chemical binding]; other site
479433021902	stacking interactions; other site
479433021903	hinge regions; other site
479433021904	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
479433021905	DNA-binding site [nucleotide binding]; DNA binding site
479433021906	RNA-binding motif; other site
479433021907	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
479433021908	MoaE interaction surface [polypeptide binding]; other site
479433021909	MoeB interaction surface [polypeptide binding]; other site
479433021910	thiocarboxylated glycine; other site
479433021911	threonine synthase; Validated; Region: PRK07591
479433021912	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
479433021913	homodimer interface [polypeptide binding]; other site
479433021914	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433021915	catalytic residue [active]
479433021916	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
479433021917	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
479433021918	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433021919	dimerization interface [polypeptide binding]; other site
479433021920	putative DNA binding site [nucleotide binding]; other site
479433021921	Predicted transcriptional regulators [Transcription]; Region: COG1378
479433021922	putative Zn2+ binding site [ion binding]; other site
479433021923	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433021924	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433021925	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
479433021926	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
479433021927	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
479433021928	active site
479433021929	dimer interface [polypeptide binding]; other site
479433021930	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
479433021931	Protein of unknown function (DUF2630); Region: DUF2630; pfam10944
479433021932	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
479433021933	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
479433021934	FtsX-like permease family; Region: FtsX; pfam02687
479433021935	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
479433021936	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
479433021937	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
479433021938	Walker A/P-loop; other site
479433021939	ATP binding site [chemical binding]; other site
479433021940	Q-loop/lid; other site
479433021941	ABC transporter signature motif; other site
479433021942	Walker B; other site
479433021943	D-loop; other site
479433021944	H-loop/switch region; other site
479433021945	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
479433021946	active site
479433021947	RNA/DNA hybrid binding site [nucleotide binding]; other site
479433021948	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
479433021949	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
479433021950	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
479433021951	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
479433021952	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
479433021953	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
479433021954	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
479433021955	substrate binding site; other site
479433021956	dimer interface; other site
479433021957	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
479433021958	homotrimer interaction site [polypeptide binding]; other site
479433021959	zinc binding site [ion binding]; other site
479433021960	CDP-binding sites; other site
479433021961	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
479433021962	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
479433021963	TPR motif; other site
479433021964	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
479433021965	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433021966	putative substrate translocation pore; other site
479433021967	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
479433021968	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
479433021969	active site
479433021970	HIGH motif; other site
479433021971	nucleotide binding site [chemical binding]; other site
479433021972	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
479433021973	KMSKS motif; other site
479433021974	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
479433021975	tRNA binding surface [nucleotide binding]; other site
479433021976	anticodon binding site; other site
479433021977	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
479433021978	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
479433021979	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
479433021980	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
479433021981	agmatinase; Region: agmatinase; TIGR01230
479433021982	oligomer interface [polypeptide binding]; other site
479433021983	putative active site [active]
479433021984	Mn binding site [ion binding]; other site
479433021985	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
479433021986	Beta-lactamase; Region: Beta-lactamase; pfam00144
479433021987	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
479433021988	histidinol-phosphatase; Provisional; Region: PRK05588
479433021989	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
479433021990	active site
479433021991	Predicted amidohydrolase [General function prediction only]; Region: COG0388
479433021992	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
479433021993	putative active site [active]
479433021994	catalytic triad [active]
479433021995	putative dimer interface [polypeptide binding]; other site
479433021996	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
479433021997	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
479433021998	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433021999	Family description; Region: VCBS; pfam13517
479433022000	Transcriptional regulator [Transcription]; Region: IclR; COG1414
479433022001	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
479433022002	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
479433022003	active site
479433022004	catalytic triad [active]
479433022005	oxyanion hole [active]
479433022006	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
479433022007	classical (c) SDRs; Region: SDR_c; cd05233
479433022008	NAD(P) binding site [chemical binding]; other site
479433022009	active site
479433022010	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
479433022011	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
479433022012	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
479433022013	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
479433022014	Walker A/P-loop; other site
479433022015	ATP binding site [chemical binding]; other site
479433022016	Q-loop/lid; other site
479433022017	ABC transporter signature motif; other site
479433022018	Walker B; other site
479433022019	D-loop; other site
479433022020	H-loop/switch region; other site
479433022021	Predicted integral membrane protein [Function unknown]; Region: COG5650
479433022022	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
479433022023	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
479433022024	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
479433022025	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
479433022026	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
479433022027	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
479433022028	Ligand binding site; other site
479433022029	Putative Catalytic site; other site
479433022030	DXD motif; other site
479433022031	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433022032	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
479433022033	NAD(P) binding site [chemical binding]; other site
479433022034	active site
479433022035	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
479433022036	Ligand binding site; other site
479433022037	Putative Catalytic site; other site
479433022038	DXD motif; other site
479433022039	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
479433022040	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
479433022041	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433022042	NAD(P) binding site [chemical binding]; other site
479433022043	active site
479433022044	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
479433022045	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
479433022046	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
479433022047	Ligand binding site; other site
479433022048	Putative Catalytic site; other site
479433022049	DXD motif; other site
479433022050	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
479433022051	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
479433022052	active site
479433022053	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
479433022054	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
479433022055	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
479433022056	active site
479433022057	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
479433022058	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
479433022059	active site
479433022060	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
479433022061	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
479433022062	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
479433022063	active site
479433022064	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
479433022065	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
479433022066	Ligand binding site; other site
479433022067	Putative Catalytic site; other site
479433022068	DXD motif; other site
479433022069	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
479433022070	active site
479433022071	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
479433022072	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
479433022073	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
479433022074	NADP binding site [chemical binding]; other site
479433022075	active site
479433022076	putative substrate binding site [chemical binding]; other site
479433022077	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
479433022078	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
479433022079	NAD binding site [chemical binding]; other site
479433022080	substrate binding site [chemical binding]; other site
479433022081	homodimer interface [polypeptide binding]; other site
479433022082	active site
479433022083	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
479433022084	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
479433022085	substrate binding site; other site
479433022086	tetramer interface; other site
479433022087	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
479433022088	Proteins of 100 residues with WXG; Region: WXG100; cl02005
479433022089	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
479433022090	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
479433022091	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
479433022092	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433022093	ATP binding site [chemical binding]; other site
479433022094	Mg2+ binding site [ion binding]; other site
479433022095	G-X-G motif; other site
479433022096	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
479433022097	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433022098	active site
479433022099	phosphorylation site [posttranslational modification]
479433022100	intermolecular recognition site; other site
479433022101	dimerization interface [polypeptide binding]; other site
479433022102	Predicted transcriptional regulators [Transcription]; Region: ArsR; COG0640
479433022103	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433022104	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433022105	active site
479433022106	phosphorylation site [posttranslational modification]
479433022107	intermolecular recognition site; other site
479433022108	dimerization interface [polypeptide binding]; other site
479433022109	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433022110	DNA binding site [nucleotide binding]
479433022111	Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630
479433022112	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
479433022113	ATP binding site [chemical binding]; other site
479433022114	Walker A motif; other site
479433022115	hexamer interface [polypeptide binding]; other site
479433022116	Walker B motif; other site
479433022117	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
479433022118	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
479433022119	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
479433022120	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
479433022121	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433022122	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433022123	active site
479433022124	phosphorylation site [posttranslational modification]
479433022125	intermolecular recognition site; other site
479433022126	dimerization interface [polypeptide binding]; other site
479433022127	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433022128	DNA binding site [nucleotide binding]
479433022129	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
479433022130	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433022131	dimer interface [polypeptide binding]; other site
479433022132	phosphorylation site [posttranslational modification]
479433022133	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433022134	ATP binding site [chemical binding]; other site
479433022135	Mg2+ binding site [ion binding]; other site
479433022136	G-X-G motif; other site
479433022137	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
479433022138	PhoU domain; Region: PhoU; pfam01895
479433022139	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433022140	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433022141	DNA binding residues [nucleotide binding]
479433022142	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
479433022143	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
479433022144	G1 box; other site
479433022145	GTP/Mg2+ binding site [chemical binding]; other site
479433022146	G2 box; other site
479433022147	Switch I region; other site
479433022148	G3 box; other site
479433022149	Switch II region; other site
479433022150	G4 box; other site
479433022151	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
479433022152	G5 box; other site
479433022153	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
479433022154	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
479433022155	Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785
479433022156	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
479433022157	catalytic core [active]
479433022158	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
479433022159	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
479433022160	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
479433022161	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
479433022162	putative ADP-binding pocket [chemical binding]; other site
479433022163	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433022164	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433022165	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
479433022166	peptidase domain interface [polypeptide binding]; other site
479433022167	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
479433022168	active site
479433022169	catalytic residues [active]
479433022170	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433022171	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433022172	non-specific DNA binding site [nucleotide binding]; other site
479433022173	salt bridge; other site
479433022174	sequence-specific DNA binding site [nucleotide binding]; other site
479433022175	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
479433022176	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433022177	TAP-like protein; Region: Abhydrolase_4; pfam08386
479433022178	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433022179	MarR family; Region: MarR; pfam01047
479433022180	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433022181	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433022182	Predicted transcriptional regulators [Transcription]; Region: COG1695
479433022183	Transcriptional regulator PadR-like family; Region: PadR; cl17335
479433022184	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
479433022185	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433022186	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
479433022187	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
479433022188	DNA binding residues [nucleotide binding]
479433022189	L-asparaginase II; Region: Asparaginase_II; pfam06089
479433022190	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
479433022191	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
479433022192	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
479433022193	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
479433022194	ferric uptake regulator; Provisional; Region: fur; PRK09462
479433022195	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
479433022196	metal binding site 2 [ion binding]; metal-binding site
479433022197	putative DNA binding helix; other site
479433022198	metal binding site 1 [ion binding]; metal-binding site
479433022199	dimer interface [polypeptide binding]; other site
479433022200	structural Zn2+ binding site [ion binding]; other site
479433022201	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
479433022202	heme-binding site [chemical binding]; other site
479433022203	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
479433022204	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
479433022205	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
479433022206	active site residue [active]
479433022207	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
479433022208	active site residue [active]
479433022209	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
479433022210	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433022211	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433022212	DNA binding residues [nucleotide binding]
479433022213	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
479433022214	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
479433022215	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
479433022216	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
479433022217	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433022218	active site
479433022219	phosphorylation site [posttranslational modification]
479433022220	intermolecular recognition site; other site
479433022221	dimerization interface [polypeptide binding]; other site
479433022222	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433022223	DNA binding site [nucleotide binding]
479433022224	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
479433022225	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
479433022226	Coenzyme A binding pocket [chemical binding]; other site
479433022227	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433022228	Coenzyme A binding pocket [chemical binding]; other site
479433022229	Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829
479433022230	active site
479433022231	putative catalytic site [active]
479433022232	polyphosphate kinase; Provisional; Region: PRK05443
479433022233	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
479433022234	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
479433022235	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
479433022236	putative domain interface [polypeptide binding]; other site
479433022237	putative active site [active]
479433022238	catalytic site [active]
479433022239	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
479433022240	putative domain interface [polypeptide binding]; other site
479433022241	putative active site [active]
479433022242	catalytic site [active]
479433022243	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
479433022244	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
479433022245	active site
479433022246	Ap6A binding site [chemical binding]; other site
479433022247	nudix motif; other site
479433022248	metal binding site [ion binding]; metal-binding site
479433022249	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
479433022250	catalytic core [active]
479433022251	PBP superfamily domain; Region: PBP_like_2; cl17296
479433022252	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
479433022253	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433022254	dimer interface [polypeptide binding]; other site
479433022255	conserved gate region; other site
479433022256	ABC-ATPase subunit interface; other site
479433022257	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
479433022258	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433022259	dimer interface [polypeptide binding]; other site
479433022260	conserved gate region; other site
479433022261	putative PBP binding loops; other site
479433022262	ABC-ATPase subunit interface; other site
479433022263	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
479433022264	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
479433022265	Walker A/P-loop; other site
479433022266	ATP binding site [chemical binding]; other site
479433022267	Q-loop/lid; other site
479433022268	ABC transporter signature motif; other site
479433022269	Walker B; other site
479433022270	D-loop; other site
479433022271	H-loop/switch region; other site
479433022272	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
479433022273	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433022274	putative Zn2+ binding site [ion binding]; other site
479433022275	putative DNA binding site [nucleotide binding]; other site
479433022276	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433022277	selenocysteine synthase; Provisional; Region: PRK04311
479433022278	GTP-binding protein YchF; Reviewed; Region: PRK09601
479433022279	YchF GTPase; Region: YchF; cd01900
479433022280	G1 box; other site
479433022281	GTP/Mg2+ binding site [chemical binding]; other site
479433022282	Switch I region; other site
479433022283	G2 box; other site
479433022284	Switch II region; other site
479433022285	G3 box; other site
479433022286	G4 box; other site
479433022287	G5 box; other site
479433022288	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
479433022289	RmuC family; Region: RmuC; pfam02646
479433022290	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
479433022291	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
479433022292	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
479433022293	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
479433022294	generic binding surface II; other site
479433022295	generic binding surface I; other site
479433022296	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700
479433022297	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
479433022298	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433022299	Coenzyme A binding pocket [chemical binding]; other site
479433022300	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
479433022301	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
479433022302	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
479433022303	putative active site [active]
479433022304	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
479433022305	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433022306	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433022307	putative substrate translocation pore; other site
479433022308	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433022309	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
479433022310	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433022311	Methyltransferase domain; Region: Methyltransf_23; pfam13489
479433022312	Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492
479433022313	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
479433022314	Ligand binding site; other site
479433022315	Putative Catalytic site; other site
479433022316	DXD motif; other site
479433022317	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433022318	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433022319	intermolecular recognition site; other site
479433022320	active site
479433022321	dimerization interface [polypeptide binding]; other site
479433022322	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433022323	DNA binding site [nucleotide binding]
479433022324	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433022325	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433022326	dimer interface [polypeptide binding]; other site
479433022327	phosphorylation site [posttranslational modification]
479433022328	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433022329	ATP binding site [chemical binding]; other site
479433022330	Mg2+ binding site [ion binding]; other site
479433022331	G-X-G motif; other site
479433022332	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
479433022333	active site
479433022334	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433022335	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433022336	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
479433022337	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
479433022338	FtsX-like permease family; Region: FtsX; pfam02687
479433022339	FtsX-like permease family; Region: FtsX; pfam02687
479433022340	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
479433022341	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
479433022342	Walker A/P-loop; other site
479433022343	ATP binding site [chemical binding]; other site
479433022344	Q-loop/lid; other site
479433022345	ABC transporter signature motif; other site
479433022346	Walker B; other site
479433022347	D-loop; other site
479433022348	H-loop/switch region; other site
479433022349	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433022350	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433022351	putative substrate translocation pore; other site
479433022352	SnoaL-like domain; Region: SnoaL_2; pfam12680
479433022353	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
479433022354	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
479433022355	N-acetyl-D-glucosamine binding site [chemical binding]; other site
479433022356	catalytic residue [active]
479433022357	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
479433022358	NlpC/P60 family; Region: NLPC_P60; pfam00877
479433022359	AAA-like domain; Region: AAA_10; pfam12846
479433022360	Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999
479433022361	active site
479433022362	Mn binding site [ion binding]; other site
479433022363	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
479433022364	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
479433022365	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433022366	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
479433022367	active site
479433022368	catalytic tetrad [active]
479433022369	AAA ATPase domain; Region: AAA_16; pfam13191
479433022370	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
479433022371	binding surface
479433022372	TPR motif; other site
479433022373	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433022374	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433022375	DNA binding residues [nucleotide binding]
479433022376	dimerization interface [polypeptide binding]; other site
479433022377	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
479433022378	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
479433022379	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433022380	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433022381	non-specific DNA binding site [nucleotide binding]; other site
479433022382	salt bridge; other site
479433022383	sequence-specific DNA binding site [nucleotide binding]; other site
479433022384	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433022385	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433022386	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433022387	DNA binding residues [nucleotide binding]
479433022388	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
479433022389	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
479433022390	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
479433022391	TM-ABC transporter signature motif; other site
479433022392	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
479433022393	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
479433022394	TM-ABC transporter signature motif; other site
479433022395	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
479433022396	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
479433022397	Walker A/P-loop; other site
479433022398	ATP binding site [chemical binding]; other site
479433022399	Q-loop/lid; other site
479433022400	ABC transporter signature motif; other site
479433022401	Walker B; other site
479433022402	D-loop; other site
479433022403	H-loop/switch region; other site
479433022404	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
479433022405	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
479433022406	Walker A/P-loop; other site
479433022407	ATP binding site [chemical binding]; other site
479433022408	Q-loop/lid; other site
479433022409	ABC transporter signature motif; other site
479433022410	Walker B; other site
479433022411	D-loop; other site
479433022412	H-loop/switch region; other site
479433022413	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
479433022414	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
479433022415	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
479433022416	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433022417	Walker A/P-loop; other site
479433022418	ATP binding site [chemical binding]; other site
479433022419	Q-loop/lid; other site
479433022420	ABC transporter signature motif; other site
479433022421	Walker B; other site
479433022422	D-loop; other site
479433022423	H-loop/switch region; other site
479433022424	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
479433022425	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433022426	Walker A/P-loop; other site
479433022427	ATP binding site [chemical binding]; other site
479433022428	Q-loop/lid; other site
479433022429	ABC transporter signature motif; other site
479433022430	Walker B; other site
479433022431	D-loop; other site
479433022432	H-loop/switch region; other site
479433022433	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
479433022434	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
479433022435	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433022436	dimer interface [polypeptide binding]; other site
479433022437	conserved gate region; other site
479433022438	putative PBP binding loops; other site
479433022439	ABC-ATPase subunit interface; other site
479433022440	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
479433022441	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433022442	dimer interface [polypeptide binding]; other site
479433022443	conserved gate region; other site
479433022444	putative PBP binding loops; other site
479433022445	ABC-ATPase subunit interface; other site
479433022446	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
479433022447	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433022448	Walker A/P-loop; other site
479433022449	ATP binding site [chemical binding]; other site
479433022450	Q-loop/lid; other site
479433022451	ABC transporter signature motif; other site
479433022452	Walker B; other site
479433022453	D-loop; other site
479433022454	H-loop/switch region; other site
479433022455	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
479433022456	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
479433022457	Walker A/P-loop; other site
479433022458	ATP binding site [chemical binding]; other site
479433022459	Q-loop/lid; other site
479433022460	ABC transporter signature motif; other site
479433022461	Walker B; other site
479433022462	D-loop; other site
479433022463	H-loop/switch region; other site
479433022464	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
479433022465	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
479433022466	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433022467	dimer interface [polypeptide binding]; other site
479433022468	conserved gate region; other site
479433022469	putative PBP binding loops; other site
479433022470	ABC-ATPase subunit interface; other site
479433022471	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
479433022472	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433022473	dimer interface [polypeptide binding]; other site
479433022474	conserved gate region; other site
479433022475	putative PBP binding loops; other site
479433022476	ABC-ATPase subunit interface; other site
479433022477	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
479433022478	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
479433022479	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
479433022480	dimer interface [polypeptide binding]; other site
479433022481	active site
479433022482	Schiff base residues; other site
479433022483	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
479433022484	homodimer interface [polypeptide binding]; other site
479433022485	active site
479433022486	SAM binding site [chemical binding]; other site
479433022487	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
479433022488	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
479433022489	active site
479433022490	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
479433022491	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
479433022492	domain interfaces; other site
479433022493	active site
479433022494	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
479433022495	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
479433022496	tRNA; other site
479433022497	putative tRNA binding site [nucleotide binding]; other site
479433022498	putative NADP binding site [chemical binding]; other site
479433022499	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
479433022500	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
479433022501	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
479433022502	CoA binding domain; Region: CoA_binding; pfam02629
479433022503	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
479433022504	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
479433022505	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
479433022506	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
479433022507	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433022508	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433022509	DNA binding residues [nucleotide binding]
479433022510	Predicted transcriptional regulators [Transcription]; Region: COG1695
479433022511	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
479433022512	cyclase homology domain; Region: CHD; cd07302
479433022513	nucleotidyl binding site; other site
479433022514	metal binding site [ion binding]; metal-binding site
479433022515	dimer interface [polypeptide binding]; other site
479433022516	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
479433022517	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
479433022518	ligand binding site [chemical binding]; other site
479433022519	flexible hinge region; other site
479433022520	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
479433022521	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
479433022522	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
479433022523	putative acyl-acceptor binding pocket; other site
479433022524	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
479433022525	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433022526	NAD(P) binding site [chemical binding]; other site
479433022527	active site
479433022528	DNA binding domain, excisionase family; Region: excise; TIGR01764
479433022529	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
479433022530	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
479433022531	FtsX-like permease family; Region: FtsX; pfam02687
479433022532	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
479433022533	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
479433022534	Walker A/P-loop; other site
479433022535	ATP binding site [chemical binding]; other site
479433022536	Q-loop/lid; other site
479433022537	ABC transporter signature motif; other site
479433022538	Walker B; other site
479433022539	D-loop; other site
479433022540	H-loop/switch region; other site
479433022541	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
479433022542	HlyD family secretion protein; Region: HlyD_2; pfam12700
479433022543	lipoyl-biotinyl attachment site [posttranslational modification]; other site
479433022544	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
479433022545	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
479433022546	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
479433022547	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
479433022548	protein binding site [polypeptide binding]; other site
479433022549	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
479433022550	active site
479433022551	metal binding site [ion binding]; metal-binding site
479433022552	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
479433022553	CoA-transferase family III; Region: CoA_transf_3; pfam02515
479433022554	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433022555	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433022556	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433022557	DNA binding residues [nucleotide binding]
479433022558	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
479433022559	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
479433022560	Proline dehydrogenase; Region: Pro_dh; cl03282
479433022561	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433022562	S-adenosylmethionine binding site [chemical binding]; other site
479433022563	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
479433022564	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
479433022565	AP (apurinic/apyrimidinic) site pocket; other site
479433022566	DNA interaction; other site
479433022567	Metal-binding active site; metal-binding site
479433022568	exopolyphosphatase; Region: exo_poly_only; TIGR03706
479433022569	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
479433022570	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
479433022571	DNA repair protein RadA; Provisional; Region: PRK11823
479433022572	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
479433022573	Walker A motif; other site
479433022574	ATP binding site [chemical binding]; other site
479433022575	Walker B motif; other site
479433022576	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
479433022577	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
479433022578	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
479433022579	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433022580	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
479433022581	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
479433022582	endonuclease III; Region: ENDO3c; smart00478
479433022583	minor groove reading motif; other site
479433022584	helix-hairpin-helix signature motif; other site
479433022585	substrate binding pocket [chemical binding]; other site
479433022586	active site
479433022587	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
479433022588	Protein of unknown function (DUF664); Region: DUF664; pfam04978
479433022589	DinB superfamily; Region: DinB_2; pfam12867
479433022590	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433022591	salt bridge; other site
479433022592	non-specific DNA binding site [nucleotide binding]; other site
479433022593	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433022594	sequence-specific DNA binding site [nucleotide binding]; other site
479433022595	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
479433022596	substrate binding site [chemical binding]; other site
479433022597	Small secreted domain (DUF320); Region: DUF320; pfam03777
479433022598	Small secreted domain (DUF320); Region: DUF320; pfam03777
479433022599	Clp protease ATP binding subunit; Region: clpC; CHL00095
479433022600	Clp amino terminal domain; Region: Clp_N; pfam02861
479433022601	Clp amino terminal domain; Region: Clp_N; pfam02861
479433022602	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433022603	Walker A motif; other site
479433022604	ATP binding site [chemical binding]; other site
479433022605	Walker B motif; other site
479433022606	arginine finger; other site
479433022607	UvrB/uvrC motif; Region: UVR; pfam02151
479433022608	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433022609	Walker A motif; other site
479433022610	ATP binding site [chemical binding]; other site
479433022611	Walker B motif; other site
479433022612	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
479433022613	Lsr2; Region: Lsr2; pfam11774
479433022614	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433022615	Coenzyme A binding pocket [chemical binding]; other site
479433022616	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
479433022617	heme-binding site [chemical binding]; other site
479433022618	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
479433022619	FAD binding pocket [chemical binding]; other site
479433022620	conserved FAD binding motif [chemical binding]; other site
479433022621	phosphate binding motif [ion binding]; other site
479433022622	beta-alpha-beta structure motif; other site
479433022623	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
479433022624	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
479433022625	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
479433022626	dimer interface [polypeptide binding]; other site
479433022627	putative anticodon binding site; other site
479433022628	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
479433022629	motif 1; other site
479433022630	dimer interface [polypeptide binding]; other site
479433022631	active site
479433022632	motif 2; other site
479433022633	motif 3; other site
479433022634	pantothenate kinase; Reviewed; Region: PRK13318
479433022635	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
479433022636	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
479433022637	dimerization interface [polypeptide binding]; other site
479433022638	active site
479433022639	L-aspartate oxidase; Provisional; Region: PRK07804
479433022640	L-aspartate oxidase; Provisional; Region: PRK06175
479433022641	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
479433022642	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
479433022643	tetramerization interface [polypeptide binding]; other site
479433022644	active site
479433022645	Pantoate-beta-alanine ligase; Region: PanC; cd00560
479433022646	pantoate--beta-alanine ligase; Region: panC; TIGR00018
479433022647	active site
479433022648	ATP-binding site [chemical binding]; other site
479433022649	pantoate-binding site; other site
479433022650	HXXH motif; other site
479433022651	Rossmann-like domain; Region: Rossmann-like; pfam10727
479433022652	Uncharacterized conserved protein [Function unknown]; Region: COG5495
479433022653	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
479433022654	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
479433022655	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
479433022656	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
479433022657	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
479433022658	active site
479433022659	intersubunit interface [polypeptide binding]; other site
479433022660	zinc binding site [ion binding]; other site
479433022661	Na+ binding site [ion binding]; other site
479433022662	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
479433022663	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
479433022664	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
479433022665	active site
479433022666	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
479433022667	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
479433022668	TAP-like protein; Region: Abhydrolase_4; pfam08386
479433022669	Protein of unknown function, DUF488; Region: DUF488; cl01246
479433022670	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
479433022671	hydrophobic ligand binding site; other site
479433022672	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433022673	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433022674	non-specific DNA binding site [nucleotide binding]; other site
479433022675	salt bridge; other site
479433022676	sequence-specific DNA binding site [nucleotide binding]; other site
479433022677	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
479433022678	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433022679	putative substrate translocation pore; other site
479433022680	thymidylate kinase; Validated; Region: tmk; PRK00698
479433022681	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
479433022682	TMP-binding site; other site
479433022683	ATP-binding site [chemical binding]; other site
479433022684	DNA polymerase III subunit delta'; Validated; Region: PRK07940
479433022685	DNA polymerase III subunit delta'; Validated; Region: PRK08485
479433022686	Cupin; Region: Cupin_6; pfam12852
479433022687	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433022688	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
479433022689	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433022690	NADH(P)-binding; Region: NAD_binding_10; pfam13460
479433022691	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
479433022692	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433022693	Domain of unknown function (DUF1772); Region: DUF1772; pfam08592
479433022694	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
479433022695	active site
479433022696	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
479433022697	Helix-turn-helix domain; Region: HTH_18; pfam12833
479433022698	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433022699	Transcriptional regulators [Transcription]; Region: FadR; COG2186
479433022700	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433022701	DNA-binding site [nucleotide binding]; DNA binding site
479433022702	FCD domain; Region: FCD; pfam07729
479433022703	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
479433022704	hydrophobic ligand binding site; other site
479433022705	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
479433022706	classical (c) SDRs; Region: SDR_c; cd05233
479433022707	NAD(P) binding site [chemical binding]; other site
479433022708	active site
479433022709	Protein of unknown function DUF2617; Region: DUF2617; pfam10936
479433022710	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
479433022711	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433022712	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433022713	active site
479433022714	phosphorylation site [posttranslational modification]
479433022715	intermolecular recognition site; other site
479433022716	dimerization interface [polypeptide binding]; other site
479433022717	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433022718	DNA binding residues [nucleotide binding]
479433022719	dimerization interface [polypeptide binding]; other site
479433022720	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
479433022721	Histidine kinase; Region: HisKA_3; pfam07730
479433022722	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433022723	ATP binding site [chemical binding]; other site
479433022724	Mg2+ binding site [ion binding]; other site
479433022725	G-X-G motif; other site
479433022726	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
479433022727	Uncharacterized conserved protein [Function unknown]; Region: COG4715
479433022728	Uncharacterized conserved protein [Function unknown]; Region: COG4715
479433022729	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
479433022730	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
479433022731	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
479433022732	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
479433022733	catalytic center binding site [active]
479433022734	ATP binding site [chemical binding]; other site
479433022735	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
479433022736	active site
479433022737	SnoaL-like domain; Region: SnoaL_3; pfam13474
479433022738	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
479433022739	dihydropteroate synthase; Region: DHPS; TIGR01496
479433022740	substrate binding pocket [chemical binding]; other site
479433022741	dimer interface [polypeptide binding]; other site
479433022742	inhibitor binding site; inhibition site
479433022743	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
479433022744	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
479433022745	homodecamer interface [polypeptide binding]; other site
479433022746	GTP cyclohydrolase I; Provisional; Region: PLN03044
479433022747	active site
479433022748	putative catalytic site residues [active]
479433022749	zinc binding site [ion binding]; other site
479433022750	GTP-CH-I/GFRP interaction surface; other site
479433022751	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
479433022752	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433022753	Walker A motif; other site
479433022754	ATP binding site [chemical binding]; other site
479433022755	Walker B motif; other site
479433022756	arginine finger; other site
479433022757	Peptidase family M41; Region: Peptidase_M41; pfam01434
479433022758	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
479433022759	active site
479433022760	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
479433022761	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
479433022762	Ligand Binding Site [chemical binding]; other site
479433022763	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
479433022764	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
479433022765	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979
479433022766	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
479433022767	putative active site [active]
479433022768	putative catalytic site [active]
479433022769	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
479433022770	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
479433022771	DNA binding residues [nucleotide binding]
479433022772	putative dimer interface [polypeptide binding]; other site
479433022773	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
479433022774	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
479433022775	inorganic pyrophosphatase; Provisional; Region: PRK02230
479433022776	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
479433022777	dimer interface [polypeptide binding]; other site
479433022778	substrate binding site [chemical binding]; other site
479433022779	metal binding sites [ion binding]; metal-binding site
479433022780	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433022781	putative DNA binding site [nucleotide binding]; other site
479433022782	dimerization interface [polypeptide binding]; other site
479433022783	putative Zn2+ binding site [ion binding]; other site
479433022784	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
479433022785	nudix motif; other site
479433022786	CGNR zinc finger; Region: zf-CGNR; pfam11706
479433022787	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
479433022788	NlpC/P60 family; Region: NLPC_P60; cl17555
479433022789	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433022790	Coenzyme A binding pocket [chemical binding]; other site
479433022791	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
479433022792	putative active site [active]
479433022793	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
479433022794	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
479433022795	active site
479433022796	interdomain interaction site; other site
479433022797	putative metal-binding site [ion binding]; other site
479433022798	nucleotide binding site [chemical binding]; other site
479433022799	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
479433022800	domain I; other site
479433022801	phosphate binding site [ion binding]; other site
479433022802	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
479433022803	domain II; other site
479433022804	domain III; other site
479433022805	nucleotide binding site [chemical binding]; other site
479433022806	DNA binding groove [nucleotide binding]
479433022807	catalytic site [active]
479433022808	domain IV; other site
479433022809	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
479433022810	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
479433022811	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
479433022812	Methyltransferase domain; Region: Methyltransf_31; pfam13847
479433022813	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433022814	S-adenosylmethionine binding site [chemical binding]; other site
479433022815	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
479433022816	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
479433022817	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433022818	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
479433022819	anti sigma factor interaction site; other site
479433022820	regulatory phosphorylation site [posttranslational modification]; other site
479433022821	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
479433022822	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
479433022823	ATP binding site [chemical binding]; other site
479433022824	putative Mg++ binding site [ion binding]; other site
479433022825	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
479433022826	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
479433022827	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
479433022828	ABC transporter; Region: ABC_tran_2; pfam12848
479433022829	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
479433022830	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433022831	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433022832	dimer interface [polypeptide binding]; other site
479433022833	phosphorylation site [posttranslational modification]
479433022834	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433022835	ATP binding site [chemical binding]; other site
479433022836	Mg2+ binding site [ion binding]; other site
479433022837	G-X-G motif; other site
479433022838	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433022839	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433022840	active site
479433022841	phosphorylation site [posttranslational modification]
479433022842	intermolecular recognition site; other site
479433022843	dimerization interface [polypeptide binding]; other site
479433022844	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433022845	DNA binding residues [nucleotide binding]
479433022846	dimerization interface [polypeptide binding]; other site
479433022847	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433022848	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433022849	active site
479433022850	phosphorylation site [posttranslational modification]
479433022851	intermolecular recognition site; other site
479433022852	dimerization interface [polypeptide binding]; other site
479433022853	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433022854	DNA binding residues [nucleotide binding]
479433022855	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433022856	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
479433022857	NAD(P) binding site [chemical binding]; other site
479433022858	active site
479433022859	Right handed beta helix region; Region: Beta_helix; pfam13229
479433022860	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433022861	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433022862	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433022863	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
479433022864	SelR domain; Region: SelR; pfam01641
479433022865	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
479433022866	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433022867	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433022868	active site
479433022869	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
479433022870	CoA-transferase family III; Region: CoA_transf_3; pfam02515
479433022871	Transcriptional regulators [Transcription]; Region: GntR; COG1802
479433022872	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433022873	DNA-binding site [nucleotide binding]; DNA binding site
479433022874	FCD domain; Region: FCD; pfam07729
479433022875	Transcriptional regulators [Transcription]; Region: PurR; COG1609
479433022876	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
479433022877	DNA binding site [nucleotide binding]
479433022878	domain linker motif; other site
479433022879	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292
479433022880	putative dimerization interface [polypeptide binding]; other site
479433022881	putative ligand binding site [chemical binding]; other site
479433022882	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
479433022883	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
479433022884	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433022885	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433022886	dimer interface [polypeptide binding]; other site
479433022887	conserved gate region; other site
479433022888	putative PBP binding loops; other site
479433022889	ABC-ATPase subunit interface; other site
479433022890	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
479433022891	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433022892	dimer interface [polypeptide binding]; other site
479433022893	conserved gate region; other site
479433022894	putative PBP binding loops; other site
479433022895	ABC-ATPase subunit interface; other site
479433022896	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
479433022897	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
479433022898	active site
479433022899	catalytic site [active]
479433022900	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
479433022901	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433022902	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433022903	Helix-turn-helix domain; Region: HTH_31; pfam13560
479433022904	sequence-specific DNA binding site [nucleotide binding]; other site
479433022905	salt bridge; other site
479433022906	Domain of unknown function (DUF397); Region: DUF397; pfam04149
479433022907	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433022908	dimerization interface [polypeptide binding]; other site
479433022909	putative DNA binding site [nucleotide binding]; other site
479433022910	putative Zn2+ binding site [ion binding]; other site
479433022911	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433022912	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433022913	active site
479433022914	ATP binding site [chemical binding]; other site
479433022915	substrate binding site [chemical binding]; other site
479433022916	activation loop (A-loop); other site
479433022917	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
479433022918	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
479433022919	putative sugar binding sites [chemical binding]; other site
479433022920	Q-X-W motif; other site
479433022921	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
479433022922	catalytic residues [active]
479433022923	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
479433022924	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
479433022925	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
479433022926	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
479433022927	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
479433022928	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
479433022929	Protein of unknown function (DUF690); Region: DUF690; cl04939
479433022930	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433022931	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433022932	active site
479433022933	dimerization interface [polypeptide binding]; other site
479433022934	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433022935	DNA binding site [nucleotide binding]
479433022936	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
479433022937	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
479433022938	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
479433022939	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
479433022940	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
479433022941	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433022942	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433022943	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
479433022944	Cytochrome P450; Region: p450; cl12078
479433022945	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
479433022946	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
479433022947	active site
479433022948	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
479433022949	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
479433022950	Bacterial Ig-like domain; Region: Big_5; pfam13205
479433022951	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
479433022952	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
479433022953	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
479433022954	inhibitor-cofactor binding pocket; inhibition site
479433022955	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433022956	catalytic residue [active]
479433022957	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
479433022958	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
479433022959	putative trimer interface [polypeptide binding]; other site
479433022960	putative CoA binding site [chemical binding]; other site
479433022961	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
479433022962	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
479433022963	inhibitor-cofactor binding pocket; inhibition site
479433022964	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433022965	catalytic residue [active]
479433022966	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
479433022967	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433022968	NAD(P) binding site [chemical binding]; other site
479433022969	active site
479433022970	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
479433022971	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
479433022972	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
479433022973	Bacterial sugar transferase; Region: Bac_transf; pfam02397
479433022974	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
479433022975	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
479433022976	active site
479433022977	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
479433022978	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
479433022979	putative active site [active]
479433022980	putative metal binding site [ion binding]; other site
479433022981	ATP-grasp domain; Region: ATP-grasp_4; cl17255
479433022982	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
479433022983	active site
479433022984	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
479433022985	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
479433022986	active site
479433022987	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
479433022988	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
479433022989	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
479433022990	active site
479433022991	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
479433022992	NAD-dependent deacetylase; Provisional; Region: PRK05333
479433022993	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
479433022994	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
479433022995	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
479433022996	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
479433022997	Interdomain contacts; other site
479433022998	Cytokine receptor motif; other site
479433022999	MoxR-like ATPases [General function prediction only]; Region: COG0714
479433023000	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
479433023001	Walker B motif; other site
479433023002	arginine finger; other site
479433023003	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
479433023004	Protein of unknown function DUF58; Region: DUF58; pfam01882
479433023005	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
479433023006	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
479433023007	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
479433023008	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
479433023009	active site
479433023010	catalytic residues [active]
479433023011	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433023012	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433023013	active site
479433023014	ATP binding site [chemical binding]; other site
479433023015	substrate binding site [chemical binding]; other site
479433023016	activation loop (A-loop); other site
479433023017	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
479433023018	Interdomain contacts; other site
479433023019	Cytokine receptor motif; other site
479433023020	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
479433023021	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
479433023022	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
479433023023	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
479433023024	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
479433023025	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
479433023026	Protein of unknown function (DUF690); Region: DUF690; cl04939
479433023027	Proteins of 100 residues with WXG; Region: WXG100; cl02005
479433023028	Proteins of 100 residues with WXG; Region: WXG100; cl02005
479433023029	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
479433023030	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
479433023031	active site
479433023032	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
479433023033	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433023034	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433023035	hypothetical protein; Provisional; Region: PRK06847
479433023036	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
479433023037	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
479433023038	mismatch recognition site; other site
479433023039	additional DNA contacts [nucleotide binding]; other site
479433023040	active site
479433023041	zinc binding site [ion binding]; other site
479433023042	DNA intercalation site [nucleotide binding]; other site
479433023043	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433023044	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433023045	sequence-specific DNA binding site [nucleotide binding]; other site
479433023046	salt bridge; other site
479433023047	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
479433023048	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
479433023049	cofactor binding site; other site
479433023050	DNA binding site [nucleotide binding]
479433023051	substrate interaction site [chemical binding]; other site
479433023052	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
479433023053	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
479433023054	Transposase; Region: DDE_Tnp_ISL3; pfam01610
479433023055	Transposase; Region: DEDD_Tnp_IS110; pfam01548
479433023056	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
479433023057	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
479433023058	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
479433023059	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
479433023060	nudix motif; other site
479433023061	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433023062	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433023063	non-specific DNA binding site [nucleotide binding]; other site
479433023064	salt bridge; other site
479433023065	sequence-specific DNA binding site [nucleotide binding]; other site
479433023066	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433023067	non-specific DNA binding site [nucleotide binding]; other site
479433023068	sequence-specific DNA binding site [nucleotide binding]; other site
479433023069	salt bridge; other site
479433023070	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
479433023071	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433023072	DNA-binding site [nucleotide binding]; DNA binding site
479433023073	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
479433023074	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
479433023075	DNA binding domain, excisionase family; Region: excise; TIGR01764
479433023076	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
479433023077	NlpC/P60 family; Region: NLPC_P60; pfam00877
479433023078	Bacterial PH domain; Region: DUF304; pfam03703
479433023079	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
479433023080	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
479433023081	ligand binding site [chemical binding]; other site
479433023082	homodimer interface [polypeptide binding]; other site
479433023083	NAD(P) binding site [chemical binding]; other site
479433023084	trimer interface B [polypeptide binding]; other site
479433023085	trimer interface A [polypeptide binding]; other site
479433023086	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
479433023087	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
479433023088	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
479433023089	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
479433023090	active site
479433023091	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
479433023092	nucleoside/Zn binding site; other site
479433023093	dimer interface [polypeptide binding]; other site
479433023094	catalytic motif [active]
479433023095	Helix-turn-helix domain; Region: HTH_17; pfam12728
479433023096	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
479433023097	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
479433023098	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
479433023099	Helix-turn-helix domain; Region: HTH_17; pfam12728
479433023100	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433023101	S-adenosylmethionine binding site [chemical binding]; other site
479433023102	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
479433023103	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
479433023104	AAA-like domain; Region: AAA_10; pfam12846
479433023105	Domain of unknown function DUF87; Region: DUF87; pfam01935
479433023106	Domain of unknown function DUF87; Region: DUF87; pfam01935
479433023107	AAA-like domain; Region: AAA_10; pfam12846
479433023108	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
479433023109	Replication-relaxation; Region: Replic_Relax; pfam13814
479433023110	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
479433023111	NlpC/P60 family; Region: NLPC_P60; pfam00877
479433023112	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433023113	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433023114	non-specific DNA binding site [nucleotide binding]; other site
479433023115	salt bridge; other site
479433023116	sequence-specific DNA binding site [nucleotide binding]; other site
479433023117	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433023118	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433023119	non-specific DNA binding site [nucleotide binding]; other site
479433023120	salt bridge; other site
479433023121	sequence-specific DNA binding site [nucleotide binding]; other site
479433023122	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
479433023123	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433023124	Mg2+ binding site [ion binding]; other site
479433023125	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433023126	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433023127	non-specific DNA binding site [nucleotide binding]; other site
479433023128	salt bridge; other site
479433023129	sequence-specific DNA binding site [nucleotide binding]; other site
479433023130	Flavoprotein; Region: Flavoprotein; pfam02441
479433023131	Helix-turn-helix domain; Region: HTH_36; pfam13730
479433023132	Bacterial transcriptional activator domain; Region: BTAD; smart01043
479433023133	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
479433023134	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
479433023135	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
479433023136	ATP binding site [chemical binding]; other site
479433023137	Walker A motif; other site
479433023138	hexamer interface [polypeptide binding]; other site
479433023139	Walker B motif; other site
479433023140	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
479433023141	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
479433023142	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433023143	DNA-binding site [nucleotide binding]; DNA binding site
479433023144	NUDIX domain; Region: NUDIX; pfam00293
479433023145	nudix motif; other site
479433023146	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
479433023147	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
479433023148	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
479433023149	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
479433023150	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
479433023151	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
479433023152	Low molecular weight phosphatase family; Region: LMWPc; cd00115
479433023153	active site
479433023154	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
479433023155	Low molecular weight phosphatase family; Region: LMWPc; cl00105
479433023156	active site
479433023157	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
479433023158	amphipathic channel; other site
479433023159	Asn-Pro-Ala signature motifs; other site
479433023160	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433023161	dimerization interface [polypeptide binding]; other site
479433023162	putative DNA binding site [nucleotide binding]; other site
479433023163	putative Zn2+ binding site [ion binding]; other site
479433023164	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
479433023165	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433023166	putative substrate translocation pore; other site
479433023167	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
479433023168	Peptidase family M28; Region: Peptidase_M28; pfam04389
479433023169	metal binding site [ion binding]; metal-binding site
479433023170	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
479433023171	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433023172	dimerization interface [polypeptide binding]; other site
479433023173	putative DNA binding site [nucleotide binding]; other site
479433023174	putative Zn2+ binding site [ion binding]; other site
479433023175	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433023176	dimerization interface [polypeptide binding]; other site
479433023177	putative DNA binding site [nucleotide binding]; other site
479433023178	putative Zn2+ binding site [ion binding]; other site
479433023179	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
479433023180	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
479433023181	NACHT domain; Region: NACHT; pfam05729
479433023182	Transposase, Mutator family; Region: Transposase_mut; pfam00872
479433023183	MULE transposase domain; Region: MULE; pfam10551
479433023184	RHS Repeat; Region: RHS_repeat; cl11982
479433023185	RHS Repeat; Region: RHS_repeat; cl11982
479433023186	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
479433023187	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
479433023188	RHS Repeat; Region: RHS_repeat; cl11982
479433023189	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
479433023190	RHS Repeat; Region: RHS_repeat; cl11982
479433023191	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
479433023192	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
479433023193	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
479433023194	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
479433023195	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
479433023196	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433023197	active site
479433023198	phosphorylation site [posttranslational modification]
479433023199	intermolecular recognition site; other site
479433023200	dimerization interface [polypeptide binding]; other site
479433023201	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
479433023202	DNA binding site [nucleotide binding]
479433023203	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
479433023204	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
479433023205	dimer interface [polypeptide binding]; other site
479433023206	phosphorylation site [posttranslational modification]
479433023207	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
479433023208	ATP binding site [chemical binding]; other site
479433023209	Mg2+ binding site [ion binding]; other site
479433023210	G-X-G motif; other site
479433023211	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
479433023212	peptidase domain interface [polypeptide binding]; other site
479433023213	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
479433023214	active site
479433023215	catalytic triad [active]
479433023216	calcium binding site [ion binding]; other site
479433023217	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433023218	putative substrate translocation pore; other site
479433023219	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433023220	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
479433023221	RHS Repeat; Region: RHS_repeat; cl11982
479433023222	RHS Repeat; Region: RHS_repeat; pfam05593
479433023223	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
479433023224	RHS Repeat; Region: RHS_repeat; pfam05593
479433023225	RHS Repeat; Region: RHS_repeat; pfam05593
479433023226	RHS Repeat; Region: RHS_repeat; pfam05593
479433023227	RHS Repeat; Region: RHS_repeat; pfam05593
479433023228	RHS Repeat; Region: RHS_repeat; cl11982
479433023229	RHS Repeat; Region: RHS_repeat; pfam05593
479433023230	RHS Repeat; Region: RHS_repeat; cl11982
479433023231	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
479433023232	Epoxide hydrolase N terminus; Region: EHN; pfam06441
479433023233	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433023234	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
479433023235	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
479433023236	RHS Repeat; Region: RHS_repeat; cl11982
479433023237	RHS Repeat; Region: RHS_repeat; pfam05593
479433023238	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
479433023239	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
479433023240	RHS Repeat; Region: RHS_repeat; cl11982
479433023241	RHS Repeat; Region: RHS_repeat; cl11982
479433023242	RHS Repeat; Region: RHS_repeat; pfam05593
479433023243	RHS Repeat; Region: RHS_repeat; cl11982
479433023244	RHS Repeat; Region: RHS_repeat; pfam05593
479433023245	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
479433023246	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433023247	dimerization interface [polypeptide binding]; other site
479433023248	putative DNA binding site [nucleotide binding]; other site
479433023249	Predicted transcriptional regulator [Transcription]; Region: COG2378
479433023250	putative Zn2+ binding site [ion binding]; other site
479433023251	WYL domain; Region: WYL; pfam13280
479433023252	Epoxide hydrolase N terminus; Region: EHN; pfam06441
479433023253	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433023254	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
479433023255	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
479433023256	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
479433023257	argininosuccinate synthase; Validated; Region: PRK05370
479433023258	short chain dehydrogenase; Provisional; Region: PRK06180
479433023259	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
479433023260	NADP binding site [chemical binding]; other site
479433023261	active site
479433023262	steroid binding site; other site
479433023263	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433023264	Domain of unknown function DUF302; Region: DUF302; cl01364
479433023265	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
479433023266	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
479433023267	dimer interface [polypeptide binding]; other site
479433023268	conserved gate region; other site
479433023269	putative PBP binding loops; other site
479433023270	ABC-ATPase subunit interface; other site
479433023271	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433023272	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
479433023273	Walker A/P-loop; other site
479433023274	ATP binding site [chemical binding]; other site
479433023275	Q-loop/lid; other site
479433023276	ABC transporter signature motif; other site
479433023277	Walker B; other site
479433023278	D-loop; other site
479433023279	H-loop/switch region; other site
479433023280	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
479433023281	tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730
479433023282	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
479433023283	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
479433023284	DNA binding residues [nucleotide binding]
479433023285	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
479433023286	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
479433023287	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433023288	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
479433023289	tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812
479433023290	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433023291	catalytic residue [active]
479433023292	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433023293	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433023294	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
479433023295	YCII-related domain; Region: YCII; cl00999
479433023296	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
479433023297	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433023298	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
479433023299	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
479433023300	metal ion-dependent adhesion site (MIDAS); other site
479433023301	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433023302	Walker A motif; other site
479433023303	ATP binding site [chemical binding]; other site
479433023304	Walker B motif; other site
479433023305	arginine finger; other site
479433023306	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
479433023307	peptidase domain interface [polypeptide binding]; other site
479433023308	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
479433023309	active site
479433023310	catalytic triad [active]
479433023311	calcium binding site [ion binding]; other site
479433023312	RNA ligase; Region: RNA_ligase; pfam09414
479433023313	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
479433023314	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433023315	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
479433023316	Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788
479433023317	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
479433023318	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
479433023319	putative NAD(P) binding site [chemical binding]; other site
479433023320	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433023321	non-specific DNA binding site [nucleotide binding]; other site
479433023322	salt bridge; other site
479433023323	sequence-specific DNA binding site [nucleotide binding]; other site
479433023324	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
479433023325	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433023326	putative substrate translocation pore; other site
479433023327	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433023328	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
479433023329	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
479433023330	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
479433023331	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
479433023332	active site
479433023333	catalytic residues [active]
479433023334	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
479433023335	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433023336	NAD(P) binding site [chemical binding]; other site
479433023337	active site
479433023338	Cupin; Region: Cupin_6; pfam12852
479433023339	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
479433023340	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
479433023341	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
479433023342	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
479433023343	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433023344	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433023345	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
479433023346	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
479433023347	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433023348	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433023349	MarR family; Region: MarR_2; cl17246
479433023350	PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939
479433023351	putative deacylase active site [active]
479433023352	Cupin; Region: Cupin_6; pfam12852
479433023353	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
479433023354	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
479433023355	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433023356	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
479433023357	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
479433023358	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
479433023359	active site
479433023360	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
479433023361	MarR family; Region: MarR_2; pfam12802
479433023362	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433023363	S-adenosylmethionine binding site [chemical binding]; other site
479433023364	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433023365	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433023366	non-specific DNA binding site [nucleotide binding]; other site
479433023367	salt bridge; other site
479433023368	sequence-specific DNA binding site [nucleotide binding]; other site
479433023369	Cupin domain; Region: Cupin_2; cl17218
479433023370	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433023371	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
479433023372	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
479433023373	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
479433023374	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
479433023375	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433023376	non-specific DNA binding site [nucleotide binding]; other site
479433023377	salt bridge; other site
479433023378	sequence-specific DNA binding site [nucleotide binding]; other site
479433023379	Cupin domain; Region: Cupin_2; pfam07883
479433023380	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433023381	Major Facilitator Superfamily; Region: MFS_1; pfam07690
479433023382	putative substrate translocation pore; other site
479433023383	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
479433023384	AAA domain; Region: AAA_30; pfam13604
479433023385	Family description; Region: UvrD_C_2; pfam13538
479433023386	hypothetical protein; Provisional; Region: PRK11770
479433023387	Domain of unknown function (DUF307); Region: DUF307; pfam03733
479433023388	Domain of unknown function (DUF307); Region: DUF307; pfam03733
479433023389	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
479433023390	MPT binding site; other site
479433023391	trimer interface [polypeptide binding]; other site
479433023392	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
479433023393	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
479433023394	Beta-lactamase; Region: Beta-lactamase; pfam00144
479433023395	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
479433023396	Putative sensor; Region: Sensor; pfam13796
479433023397	MMPL family; Region: MMPL; pfam03176
479433023398	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
479433023399	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433023400	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
479433023401	DNA binding residues [nucleotide binding]
479433023402	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433023403	NADH(P)-binding; Region: NAD_binding_10; pfam13460
479433023404	NAD(P) binding site [chemical binding]; other site
479433023405	active site
479433023406	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433023407	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433023408	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433023409	DNA binding residues [nucleotide binding]
479433023410	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
479433023411	Ligand Binding Site [chemical binding]; other site
479433023412	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433023413	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433023414	active site
479433023415	ATP binding site [chemical binding]; other site
479433023416	substrate binding site [chemical binding]; other site
479433023417	activation loop (A-loop); other site
479433023418	PQQ-like domain; Region: PQQ_2; pfam13360
479433023419	Uncharacterized conserved protein [Function unknown]; Region: COG2966
479433023420	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
479433023421	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
479433023422	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
479433023423	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
479433023424	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
479433023425	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433023426	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433023427	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433023428	PKD domain; Region: PKD; pfam00801
479433023429	FOG: PKD repeat [General function prediction only]; Region: COG3291
479433023430	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433023431	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433023432	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433023433	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
479433023434	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
479433023435	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433023436	catalytic residue [active]
479433023437	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
479433023438	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
479433023439	short chain dehydrogenase; Validated; Region: PRK05855
479433023440	classical (c) SDRs; Region: SDR_c; cd05233
479433023441	NAD(P) binding site [chemical binding]; other site
479433023442	active site
479433023443	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
479433023444	active site
479433023445	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433023446	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433023447	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433023448	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433023449	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433023450	DNA binding residues [nucleotide binding]
479433023451	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
479433023452	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
479433023453	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
479433023454	putative active site [active]
479433023455	putative substrate binding site [chemical binding]; other site
479433023456	putative cosubstrate binding site; other site
479433023457	catalytic site [active]
479433023458	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
479433023459	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
479433023460	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
479433023461	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
479433023462	acyl-activating enzyme (AAE) consensus motif; other site
479433023463	putative AMP binding site [chemical binding]; other site
479433023464	putative active site [active]
479433023465	putative CoA binding site [chemical binding]; other site
479433023466	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433023467	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
479433023468	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
479433023469	catalytic triad [active]
479433023470	conserved cis-peptide bond; other site
479433023471	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
479433023472	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
479433023473	FAD binding site [chemical binding]; other site
479433023474	substrate binding site [chemical binding]; other site
479433023475	catalytic base [active]
479433023476	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
479433023477	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
479433023478	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
479433023479	Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630
479433023480	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
479433023481	Walker A motif; other site
479433023482	ATP binding site [chemical binding]; other site
479433023483	Walker B motif; other site
479433023484	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
479433023485	Putative cyclase; Region: Cyclase; pfam04199
479433023486	short chain dehydrogenase; Provisional; Region: PRK07791
479433023487	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433023488	NAD(P) binding site [chemical binding]; other site
479433023489	active site
479433023490	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
479433023491	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
479433023492	NAD binding site [chemical binding]; other site
479433023493	catalytic Zn binding site [ion binding]; other site
479433023494	substrate binding site [chemical binding]; other site
479433023495	structural Zn binding site [ion binding]; other site
479433023496	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
479433023497	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
479433023498	enoyl-CoA hydratase; Provisional; Region: PRK06688
479433023499	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
479433023500	substrate binding site [chemical binding]; other site
479433023501	oxyanion hole (OAH) forming residues; other site
479433023502	trimer interface [polypeptide binding]; other site
479433023503	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
479433023504	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
479433023505	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
479433023506	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433023507	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433023508	acyl-activating enzyme (AAE) consensus motif; other site
479433023509	acyl-activating enzyme (AAE) consensus motif; other site
479433023510	AMP binding site [chemical binding]; other site
479433023511	active site
479433023512	CoA binding site [chemical binding]; other site
479433023513	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433023514	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433023515	short chain dehydrogenase; Provisional; Region: PRK07856
479433023516	classical (c) SDRs; Region: SDR_c; cd05233
479433023517	NAD(P) binding site [chemical binding]; other site
479433023518	active site
479433023519	enoyl-CoA hydratase; Provisional; Region: PRK09076
479433023520	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
479433023521	substrate binding site [chemical binding]; other site
479433023522	oxyanion hole (OAH) forming residues; other site
479433023523	trimer interface [polypeptide binding]; other site
479433023524	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
479433023525	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
479433023526	lipid-transfer protein; Provisional; Region: PRK07855
479433023527	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
479433023528	active site
479433023529	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
479433023530	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
479433023531	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
479433023532	acyl-activating enzyme (AAE) consensus motif; other site
479433023533	acyl-activating enzyme (AAE) consensus motif; other site
479433023534	putative AMP binding site [chemical binding]; other site
479433023535	putative active site [active]
479433023536	putative CoA binding site [chemical binding]; other site
479433023537	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433023538	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433023539	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433023540	DNA binding residues [nucleotide binding]
479433023541	FO synthase; Reviewed; Region: fbiC; PRK09234
479433023542	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433023543	FeS/SAM binding site; other site
479433023544	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433023545	FeS/SAM binding site; other site
479433023546	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
479433023547	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433023548	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433023549	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
479433023550	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
479433023551	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
479433023552	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
479433023553	NAD(P) binding site [chemical binding]; other site
479433023554	active site
479433023555	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433023556	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
479433023557	Transcriptional regulator [Transcription]; Region: LytR; COG1316
479433023558	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
479433023559	short chain dehydrogenase; Provisional; Region: PRK07890
479433023560	classical (c) SDRs; Region: SDR_c; cd05233
479433023561	NAD(P) binding site [chemical binding]; other site
479433023562	active site
479433023563	PknH-like extracellular domain; Region: PknH_C; pfam14032
479433023564	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
479433023565	DNA-binding residues [nucleotide binding]; DNA binding site
479433023566	nucleotide binding site [chemical binding]; other site
479433023567	polymerase nucleotide-binding site; other site
479433023568	primase nucleotide-binding site [nucleotide binding]; other site
479433023569	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
479433023570	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
479433023571	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
479433023572	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433023573	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
479433023574	putative DNA binding site [nucleotide binding]; other site
479433023575	putative Zn2+ binding site [ion binding]; other site
479433023576	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433023577	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433023578	putative substrate translocation pore; other site
479433023579	Peptidase family M48; Region: Peptidase_M48; cl12018
479433023580	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
479433023581	Fe-S cluster binding site [ion binding]; other site
479433023582	active site
479433023583	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
479433023584	active site 2 [active]
479433023585	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
479433023586	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
479433023587	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
479433023588	citrate synthase 2; Provisional; Region: PRK12350
479433023589	Citrate synthase; Region: Citrate_synt; pfam00285
479433023590	oxalacetate binding site [chemical binding]; other site
479433023591	citrylCoA binding site [chemical binding]; other site
479433023592	coenzyme A binding site [chemical binding]; other site
479433023593	catalytic triad [active]
479433023594	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
479433023595	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433023596	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433023597	DNA binding residues [nucleotide binding]
479433023598	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
479433023599	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433023600	catalytic residue [active]
479433023601	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
479433023602	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
479433023603	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
479433023604	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433023605	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433023606	putative substrate translocation pore; other site
479433023607	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
479433023608	trimer interface [polypeptide binding]; other site
479433023609	active site
479433023610	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
479433023611	peptidase domain interface [polypeptide binding]; other site
479433023612	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
479433023613	active site
479433023614	catalytic triad [active]
479433023615	calcium binding site [ion binding]; other site
479433023616	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
479433023617	Beta-lactamase; Region: Beta-lactamase; pfam00144
479433023618	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433023619	DNA-binding site [nucleotide binding]; DNA binding site
479433023620	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
479433023621	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
479433023622	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433023623	homodimer interface [polypeptide binding]; other site
479433023624	catalytic residue [active]
479433023625	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
479433023626	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
479433023627	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
479433023628	catalytic residue [active]
479433023629	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433023630	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433023631	putative substrate translocation pore; other site
479433023632	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
479433023633	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
479433023634	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433023635	salt bridge; other site
479433023636	non-specific DNA binding site [nucleotide binding]; other site
479433023637	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
479433023638	sequence-specific DNA binding site [nucleotide binding]; other site
479433023639	Predicted transcriptional regulators [Transcription]; Region: COG1695
479433023640	Transcriptional regulator PadR-like family; Region: PadR; cl17335
479433023641	Nuclease-related domain; Region: NERD; pfam08378
479433023642	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
479433023643	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
479433023644	active site
479433023645	metal binding site [ion binding]; metal-binding site
479433023646	Protein of unknown function (DUF664); Region: DUF664; pfam04978
479433023647	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
479433023648	ThiC-associated domain; Region: ThiC-associated; pfam13667
479433023649	ThiC family; Region: ThiC; pfam01964
479433023650	Predicted transcriptional regulator [Transcription]; Region: COG3655
479433023651	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
479433023652	Transcriptional regulators [Transcription]; Region: MarR; COG1846
479433023653	MarR family; Region: MarR_2; pfam12802
479433023654	Membrane protein of unknown function; Region: DUF360; pfam04020
479433023655	Phosphotransferase enzyme family; Region: APH; pfam01636
479433023656	Fructosamine kinase; Region: Fructosamin_kin; cl17579
479433023657	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
479433023658	active site
479433023659	catalytic site [active]
479433023660	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
479433023661	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
479433023662	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
479433023663	FAD binding site [chemical binding]; other site
479433023664	substrate binding site [chemical binding]; other site
479433023665	catalytic residues [active]
479433023666	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
479433023667	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
479433023668	putative active site [active]
479433023669	Thioredoxin-like; Region: Thioredoxin_7; pfam13899
479433023670	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
479433023671	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
479433023672	Walker A/P-loop; other site
479433023673	ATP binding site [chemical binding]; other site
479433023674	Q-loop/lid; other site
479433023675	ABC transporter signature motif; other site
479433023676	Walker B; other site
479433023677	D-loop; other site
479433023678	H-loop/switch region; other site
479433023679	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
479433023680	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
479433023681	Walker A/P-loop; other site
479433023682	ATP binding site [chemical binding]; other site
479433023683	Q-loop/lid; other site
479433023684	ABC transporter signature motif; other site
479433023685	Walker B; other site
479433023686	D-loop; other site
479433023687	H-loop/switch region; other site
479433023688	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
479433023689	TM-ABC transporter signature motif; other site
479433023690	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
479433023691	TM-ABC transporter signature motif; other site
479433023692	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
479433023693	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
479433023694	Soluble P-type ATPase [General function prediction only]; Region: COG4087
479433023695	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
479433023696	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433023697	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433023698	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433023699	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
479433023700	active site
479433023701	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433023702	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433023703	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433023704	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
479433023705	Predicted membrane protein [Function unknown]; Region: COG2246
479433023706	GtrA-like protein; Region: GtrA; pfam04138
479433023707	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
479433023708	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
479433023709	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
479433023710	Ligand binding site; other site
479433023711	Putative Catalytic site; other site
479433023712	DXD motif; other site
479433023713	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
479433023714	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433023715	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433023716	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
479433023717	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
479433023718	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
479433023719	metal-binding site [ion binding]
479433023720	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
479433023721	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
479433023722	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
479433023723	active site
479433023724	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433023725	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433023726	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433023727	DNA binding residues [nucleotide binding]
479433023728	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
479433023729	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
479433023730	dimer interface [polypeptide binding]; other site
479433023731	acyl-activating enzyme (AAE) consensus motif; other site
479433023732	putative active site [active]
479433023733	AMP binding site [chemical binding]; other site
479433023734	putative CoA binding site [chemical binding]; other site
479433023735	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433023736	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433023737	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433023738	DNA binding residues [nucleotide binding]
479433023739	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
479433023740	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
479433023741	putative ligand binding site [chemical binding]; other site
479433023742	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
479433023743	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
479433023744	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
479433023745	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
479433023746	ABC-ATPase subunit  interface; other site
479433023747	dimer interface [polypeptide binding]; other site
479433023748	putative PBP binding regions; other site
479433023749	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
479433023750	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
479433023751	intersubunit interface [polypeptide binding]; other site
479433023752	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
479433023753	enoyl-CoA hydratase; Provisional; Region: PRK07657
479433023754	substrate binding site [chemical binding]; other site
479433023755	oxyanion hole (OAH) forming residues; other site
479433023756	trimer interface [polypeptide binding]; other site
479433023757	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
479433023758	hypothetical protein; Provisional; Region: PRK01346
479433023759	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
479433023760	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433023761	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
479433023762	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
479433023763	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
479433023764	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
479433023765	putative active site [active]
479433023766	putative CoA binding site [chemical binding]; other site
479433023767	nudix motif; other site
479433023768	metal binding site [ion binding]; metal-binding site
479433023769	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
479433023770	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
479433023771	minor groove reading motif; other site
479433023772	helix-hairpin-helix signature motif; other site
479433023773	substrate binding pocket [chemical binding]; other site
479433023774	active site
479433023775	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
479433023776	short chain dehydrogenase; Provisional; Region: PRK06180
479433023777	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
479433023778	NADP binding site [chemical binding]; other site
479433023779	active site
479433023780	steroid binding site; other site
479433023781	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433023782	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433023783	elongation factor Tu; Reviewed; Region: PRK12736
479433023784	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
479433023785	G1 box; other site
479433023786	GEF interaction site [polypeptide binding]; other site
479433023787	GTP/Mg2+ binding site [chemical binding]; other site
479433023788	Switch I region; other site
479433023789	G2 box; other site
479433023790	G3 box; other site
479433023791	Switch II region; other site
479433023792	G4 box; other site
479433023793	G5 box; other site
479433023794	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
479433023795	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
479433023796	Antibiotic Binding Site [chemical binding]; other site
479433023797	Protein of unknown function (DUF1062); Region: DUF1062; cl01786
479433023798	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
479433023799	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
479433023800	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
479433023801	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433023802	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433023803	DNA binding residues [nucleotide binding]
479433023804	Uncharacterized conserved protein [Function unknown]; Region: COG2128
479433023805	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
479433023806	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
479433023807	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
479433023808	Walker A/P-loop; other site
479433023809	ATP binding site [chemical binding]; other site
479433023810	Q-loop/lid; other site
479433023811	ABC transporter signature motif; other site
479433023812	Walker B; other site
479433023813	D-loop; other site
479433023814	H-loop/switch region; other site
479433023815	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
479433023816	ABC-2 type transporter; Region: ABC2_membrane; cl17235
479433023817	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
479433023818	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
479433023819	DNA binding residues [nucleotide binding]
479433023820	dimer interface [polypeptide binding]; other site
479433023821	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
479433023822	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433023823	YCII-related domain; Region: YCII; cl00999
479433023824	Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563
479433023825	active site triad [active]
479433023826	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
479433023827	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
479433023828	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
479433023829	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
479433023830	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
479433023831	Uncharacterized conserved protein [Function unknown]; Region: COG2128
479433023832	TM1410 hypothetical-related protein; Region: DUF297; pfam03537
479433023833	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
479433023834	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
479433023835	putative NAD(P) binding site [chemical binding]; other site
479433023836	putative substrate binding site [chemical binding]; other site
479433023837	catalytic Zn binding site [ion binding]; other site
479433023838	structural Zn binding site [ion binding]; other site
479433023839	dimer interface [polypeptide binding]; other site
479433023840	Predicted transcriptional regulators [Transcription]; Region: COG1725
479433023841	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433023842	DNA-binding site [nucleotide binding]; DNA binding site
479433023843	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
479433023844	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
479433023845	Walker A/P-loop; other site
479433023846	ATP binding site [chemical binding]; other site
479433023847	Q-loop/lid; other site
479433023848	ABC transporter signature motif; other site
479433023849	Walker B; other site
479433023850	D-loop; other site
479433023851	H-loop/switch region; other site
479433023852	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
479433023853	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433023854	DNA-binding site [nucleotide binding]; DNA binding site
479433023855	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
479433023856	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433023857	homodimer interface [polypeptide binding]; other site
479433023858	catalytic residue [active]
479433023859	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
479433023860	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
479433023861	active site
479433023862	metal binding site [ion binding]; metal-binding site
479433023863	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
479433023864	elongation factor G; Reviewed; Region: PRK12740
479433023865	G1 box; other site
479433023866	putative GEF interaction site [polypeptide binding]; other site
479433023867	GTP/Mg2+ binding site [chemical binding]; other site
479433023868	Switch I region; other site
479433023869	G2 box; other site
479433023870	G3 box; other site
479433023871	Switch II region; other site
479433023872	G4 box; other site
479433023873	G5 box; other site
479433023874	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
479433023875	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
479433023876	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
479433023877	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
479433023878	TIGR03086 family protein; Region: TIGR03086
479433023879	N-acetyltransferase; Region: Acetyltransf_2; pfam00797
479433023880	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
479433023881	substrate binding site [chemical binding]; other site
479433023882	tetracycline repressor protein TetR; Provisional; Region: PRK13756
479433023883	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433023884	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
479433023885	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
479433023886	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433023887	putative substrate translocation pore; other site
479433023888	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433023889	metabolite-proton symporter; Region: 2A0106; TIGR00883
479433023890	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
479433023891	putative substrate translocation pore; other site
479433023892	Epoxide hydrolase N terminus; Region: EHN; pfam06441
479433023893	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
479433023894	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
479433023895	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
479433023896	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
479433023897	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
479433023898	Histidine kinase; Region: HisKA_3; pfam07730
479433023899	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
479433023900	Mg2+ binding site [ion binding]; other site
479433023901	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
479433023902	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
479433023903	active site
479433023904	phosphorylation site [posttranslational modification]
479433023905	intermolecular recognition site; other site
479433023906	dimerization interface [polypeptide binding]; other site
479433023907	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
479433023908	DNA binding residues [nucleotide binding]
479433023909	dimerization interface [polypeptide binding]; other site
479433023910	Uncharacterized conserved protein [Function unknown]; Region: COG2128
479433023911	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
479433023912	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
479433023913	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
479433023914	DNA-binding site [nucleotide binding]; DNA binding site
479433023915	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
479433023916	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433023917	homodimer interface [polypeptide binding]; other site
479433023918	catalytic residue [active]
479433023919	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
479433023920	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
479433023921	ligand binding site [chemical binding]; other site
479433023922	flexible hinge region; other site
479433023923	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
479433023924	putative switch regulator; other site
479433023925	non-specific DNA interactions [nucleotide binding]; other site
479433023926	DNA binding site [nucleotide binding]
479433023927	sequence specific DNA binding site [nucleotide binding]; other site
479433023928	putative cAMP binding site [chemical binding]; other site
479433023929	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
479433023930	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
479433023931	Nucleotide binding site [chemical binding]; other site
479433023932	DTAP/Switch II; other site
479433023933	Switch I; other site
479433023934	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
479433023935	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
479433023936	DTAP/Switch II; other site
479433023937	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
479433023938	Catalytic domain of Protein Kinases; Region: PKc; cd00180
479433023939	active site
479433023940	ATP binding site [chemical binding]; other site
479433023941	substrate binding site [chemical binding]; other site
479433023942	activation loop (A-loop); other site
479433023943	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
479433023944	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
479433023945	homotrimer interaction site [polypeptide binding]; other site
479433023946	putative active site [active]
479433023947	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
479433023948	nudix motif; other site
479433023949	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
479433023950	Transcription factor WhiB; Region: Whib; pfam02467
479433023951	Transglycosylase; Region: Transgly; pfam00912
479433023952	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
479433023953	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
479433023954	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
479433023955	classical (c) SDRs; Region: SDR_c; cd05233
479433023956	NAD(P) binding site [chemical binding]; other site
479433023957	active site
479433023958	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433023959	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433023960	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433023961	DNA binding residues [nucleotide binding]
479433023962	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
479433023963	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
479433023964	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
479433023965	DNA binding site [nucleotide binding]
479433023966	active site
479433023967	Int/Topo IB signature motif; other site
479433023968	Helix-turn-helix domain; Region: HTH_17; pfam12728
479433023969	PLD-like domain; Region: PLDc_2; pfam13091
479433023970	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
479433023971	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
479433023972	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
479433023973	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
479433023974	NlpC/P60 family; Region: NLPC_P60; pfam00877
479433023975	Helix-turn-helix domain; Region: HTH_19; pfam12844
479433023976	sequence-specific DNA binding site [nucleotide binding]; other site
479433023977	salt bridge; other site
479433023978	AAA-like domain; Region: AAA_10; pfam12846
479433023979	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
479433023980	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
479433023981	Walker A motif; other site
479433023982	ATP binding site [chemical binding]; other site
479433023983	Walker B motif; other site
479433023984	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
479433023985	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
479433023986	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
479433023987	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
479433023988	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
479433023989	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
479433023990	putative active site [active]
479433023991	hypothetical protein; Provisional; Region: PRK06762
479433023992	AAA domain; Region: AAA_33; pfam13671
479433023993	methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364
479433023994	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433023995	S-adenosylmethionine binding site [chemical binding]; other site
479433023996	Phosphotransferase enzyme family; Region: APH; pfam01636
479433023997	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433023998	active site
479433023999	catalytic tetrad [active]
479433024000	Cupin-like domain; Region: Cupin_8; pfam13621
479433024001	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
479433024002	active site
479433024003	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
479433024004	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
479433024005	Coenzyme A binding pocket [chemical binding]; other site
479433024006	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
479433024007	Amino acid permease; Region: AA_permease; pfam00324
479433024008	Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719
479433024009	Protein of unknown function DUF45; Region: DUF45; cl00636
479433024010	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
479433024011	catalytic tetrad [active]
479433024012	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
479433024013	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
479433024014	motif II; other site
479433024015	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
479433024016	non-specific DNA binding site [nucleotide binding]; other site
479433024017	salt bridge; other site
479433024018	sequence-specific DNA binding site [nucleotide binding]; other site
479433024019	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
479433024020	nudix motif; other site
479433024021	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
479433024022	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
479433024023	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
479433024024	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
479433024025	active site
479433024026	NTP binding site [chemical binding]; other site
479433024027	metal binding triad [ion binding]; metal-binding site
479433024028	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433024029	Radical SAM superfamily; Region: Radical_SAM; pfam04055
479433024030	FeS/SAM binding site; other site
479433024031	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
479433024032	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
479433024033	FeS/SAM binding site; other site
479433024034	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
479433024035	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
479433024036	Amidase; Region: Amidase; cl11426
479433024037	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
479433024038	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
479433024039	active site
479433024040	HIGH motif; other site
479433024041	nucleotide binding site [chemical binding]; other site
479433024042	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
479433024043	active site
479433024044	KMSKS motif; other site
479433024045	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
479433024046	TrwC relaxase; Region: TrwC; pfam08751
479433024047	AAA domain; Region: AAA_30; pfam13604
479433024048	Family description; Region: UvrD_C_2; pfam13538
479433024049	Protein of unknown function (DUF2637); Region: DUF2637; pfam10935
479433024050	UvsW helicase; Provisional; Region: uvsW; PHA02558
479433024051	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
479433024052	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
479433024053	dimer interface [polypeptide binding]; other site
479433024054	ssDNA binding site [nucleotide binding]; other site
479433024055	tetramer (dimer of dimers) interface [polypeptide binding]; other site
479433024056	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
479433024057	ParB-like nuclease domain; Region: ParB; smart00470
479433024058	Domain of unknown function (DUF932); Region: DUF932; pfam06067
479433024059	Predicted phosphohydrolases [General function prediction only]; Region: COG1408
479433024060	active site
479433024061	metal binding site [ion binding]; metal-binding site
479433024062	Yqey-like protein; Region: YqeY; cl17540
479433024063	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
479433024064	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
479433024065	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
479433024066	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
479433024067	active site
479433024068	Penicillinase repressor; Region: Pencillinase_R; pfam03965
479433024069	Peptidase family M48; Region: Peptidase_M48; cl12018
479433024070	Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041
479433024071	hypothetical protein; Provisional; Region: PRK01842
479433024072	SEC-C motif; Region: SEC-C; pfam02810
479433024073	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433024074	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433024075	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433024076	DNA binding residues [nucleotide binding]
479433024077	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
479433024078	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
479433024079	aspartate kinase; Reviewed; Region: PRK06635
479433024080	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
479433024081	putative nucleotide binding site [chemical binding]; other site
479433024082	putative catalytic residues [active]
479433024083	putative Mg ion binding site [ion binding]; other site
479433024084	putative aspartate binding site [chemical binding]; other site
479433024085	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
479433024086	putative allosteric regulatory site; other site
479433024087	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
479433024088	putative allosteric regulatory residue; other site
479433024089	recombination protein RecR; Reviewed; Region: recR; PRK00076
479433024090	RecR protein; Region: RecR; pfam02132
479433024091	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
479433024092	putative active site [active]
479433024093	putative metal-binding site [ion binding]; other site
479433024094	tetramer interface [polypeptide binding]; other site
479433024095	hypothetical protein; Validated; Region: PRK00153
479433024096	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
479433024097	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
479433024098	Walker A motif; other site
479433024099	ATP binding site [chemical binding]; other site
479433024100	Walker B motif; other site
479433024101	arginine finger; other site
479433024102	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
479433024103	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
479433024104	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
479433024105	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433024106	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433024107	DNA binding residues [nucleotide binding]
479433024108	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
479433024109	H+ Antiporter protein; Region: 2A0121; TIGR00900
479433024110	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
479433024111	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
479433024112	active site
479433024113	NTP binding site [chemical binding]; other site
479433024114	metal binding triad [ion binding]; metal-binding site
479433024115	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
479433024116	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
479433024117	Zn2+ binding site [ion binding]; other site
479433024118	Mg2+ binding site [ion binding]; other site
479433024119	Domain of unknwon function (DUF3824); Region: DUF3824; pfam12868
479433024120	integral membrane protein MviN; Region: mviN; TIGR01695
479433024121	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
479433024122	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
479433024123	active site
479433024124	ATP binding site [chemical binding]; other site
479433024125	substrate binding site [chemical binding]; other site
479433024126	activation loop (A-loop); other site
479433024127	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
479433024128	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
479433024129	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
479433024130	DNA binding residues [nucleotide binding]
479433024131	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
479433024132	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
479433024133	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
479433024134	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
479433024135	catalytic residues [active]
479433024136	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
479433024137	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
479433024138	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
479433024139	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
479433024140	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
479433024141	active site
479433024142	metal binding site [ion binding]; metal-binding site
479433024143	Domain of unknown function (DUF371); Region: DUF371; cl00916
479433024144	Putative methyltransferase; Region: Methyltransf_4; cl17290
479433024145	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
479433024146	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
479433024147	pyridoxal 5'-phosphate binding site [chemical binding]; other site
479433024148	homodimer interface [polypeptide binding]; other site
479433024149	catalytic residue [active]
479433024150	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
479433024151	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
479433024152	ATP-grasp domain; Region: ATP-grasp_4; cl17255
479433024153	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
479433024154	ParB-like nuclease domain; Region: ParBc; pfam02195
479433024155	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
479433024156	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
479433024157	Magnesium ion binding site [ion binding]; other site
479433024158	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
479433024159	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
479433024160	S-adenosylmethionine binding site [chemical binding]; other site
479433024161	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
479433024162	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
479433024163	G-X-X-G motif; other site
479433024164	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
479433024165	RxxxH motif; other site
479433024166	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
479433024167	Haemolytic domain; Region: Haemolytic; pfam01809
479433024168	Ribonuclease P; Region: Ribonuclease_P; cl00457
479433024169	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399