-- dump date 20140619_030332 -- class Genbank::misc_feature -- table misc_feature_note -- id note 509190000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 509190000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 509190000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509190000004 Walker A motif; other site 509190000005 ATP binding site [chemical binding]; other site 509190000006 Walker B motif; other site 509190000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 509190000008 DnaA box-binding interface [nucleotide binding]; other site 509190000009 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 509190000010 chaperone protein DnaJ; Provisional; Region: PRK10767 509190000011 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 509190000012 HSP70 interaction site [polypeptide binding]; other site 509190000013 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 509190000014 substrate binding site [polypeptide binding]; other site 509190000015 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 509190000016 Zn binding sites [ion binding]; other site 509190000017 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 509190000018 dimer interface [polypeptide binding]; other site 509190000019 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 509190000020 MutS domain I; Region: MutS_I; pfam01624 509190000021 MutS domain II; Region: MutS_II; pfam05188 509190000022 MutS domain III; Region: MutS_III; pfam05192 509190000023 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 509190000024 Walker A/P-loop; other site 509190000025 ATP binding site [chemical binding]; other site 509190000026 Q-loop/lid; other site 509190000027 ABC transporter signature motif; other site 509190000028 Walker B; other site 509190000029 D-loop; other site 509190000030 H-loop/switch region; other site 509190000031 PII uridylyl-transferase; Provisional; Region: PRK05092 509190000032 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 509190000033 metal binding triad; other site 509190000034 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 509190000035 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 509190000036 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 509190000037 Thioredoxin; Region: Thioredoxin_4; pfam13462 509190000038 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 509190000039 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 509190000040 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 509190000041 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 509190000042 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 509190000043 active site 509190000044 HIGH motif; other site 509190000045 dimer interface [polypeptide binding]; other site 509190000046 KMSKS motif; other site 509190000047 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 509190000048 Cytochrome P450; Region: p450; cl12078 509190000049 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 509190000050 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 509190000051 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 509190000052 putative FMN binding site [chemical binding]; other site 509190000053 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 509190000054 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 509190000055 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 509190000056 Glycoprotease family; Region: Peptidase_M22; pfam00814 509190000057 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 509190000058 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 509190000059 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 509190000060 metal binding site 2 [ion binding]; metal-binding site 509190000061 putative DNA binding helix; other site 509190000062 metal binding site 1 [ion binding]; metal-binding site 509190000063 dimer interface [polypeptide binding]; other site 509190000064 structural Zn2+ binding site [ion binding]; other site 509190000065 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 509190000066 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 509190000067 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509190000068 FeS/SAM binding site; other site 509190000069 TRAM domain; Region: TRAM; cl01282 509190000070 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 509190000071 PhoH-like protein; Region: PhoH; pfam02562 509190000072 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 509190000073 FOG: CBS domain [General function prediction only]; Region: COG0517 509190000074 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 509190000075 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 509190000076 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 509190000077 putative active site [active] 509190000078 catalytic triad [active] 509190000079 putative dimer interface [polypeptide binding]; other site 509190000080 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 509190000081 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509190000082 non-specific DNA binding site [nucleotide binding]; other site 509190000083 salt bridge; other site 509190000084 sequence-specific DNA binding site [nucleotide binding]; other site 509190000085 S-adenosylmethionine synthetase; Validated; Region: PRK05250 509190000086 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 509190000087 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 509190000088 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 509190000089 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 509190000090 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 509190000091 dimer interface [polypeptide binding]; other site 509190000092 substrate binding site [chemical binding]; other site 509190000093 metal binding sites [ion binding]; metal-binding site 509190000094 ribosome maturation protein RimP; Reviewed; Region: PRK00092 509190000095 Sm and related proteins; Region: Sm_like; cl00259 509190000096 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 509190000097 putative oligomer interface [polypeptide binding]; other site 509190000098 putative RNA binding site [nucleotide binding]; other site 509190000099 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 509190000100 NusA N-terminal domain; Region: NusA_N; pfam08529 509190000101 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 509190000102 RNA binding site [nucleotide binding]; other site 509190000103 homodimer interface [polypeptide binding]; other site 509190000104 NusA-like KH domain; Region: KH_5; pfam13184 509190000105 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 509190000106 G-X-X-G motif; other site 509190000107 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 509190000108 hypothetical protein; Provisional; Region: PRK09190 509190000109 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 509190000110 putative RNA binding cleft [nucleotide binding]; other site 509190000111 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 509190000112 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 509190000113 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 509190000114 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 509190000115 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 509190000116 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 509190000117 RNA binding site [nucleotide binding]; other site 509190000118 active site 509190000119 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 509190000120 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 509190000121 16S/18S rRNA binding site [nucleotide binding]; other site 509190000122 S13e-L30e interaction site [polypeptide binding]; other site 509190000123 25S rRNA binding site [nucleotide binding]; other site 509190000124 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 509190000125 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 509190000126 RNase E interface [polypeptide binding]; other site 509190000127 trimer interface [polypeptide binding]; other site 509190000128 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 509190000129 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 509190000130 RNase E interface [polypeptide binding]; other site 509190000131 trimer interface [polypeptide binding]; other site 509190000132 active site 509190000133 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 509190000134 putative nucleic acid binding region [nucleotide binding]; other site 509190000135 G-X-X-G motif; other site 509190000136 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 509190000137 RNA binding site [nucleotide binding]; other site 509190000138 domain interface; other site 509190000139 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 509190000140 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 509190000141 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509190000142 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 509190000143 B1 nucleotide binding pocket [chemical binding]; other site 509190000144 B2 nucleotide binding pocket [chemical binding]; other site 509190000145 CAS motifs; other site 509190000146 active site 509190000147 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 509190000148 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 509190000149 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190000150 N-terminal plug; other site 509190000151 ligand-binding site [chemical binding]; other site 509190000152 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 509190000153 PAS domain S-box; Region: sensory_box; TIGR00229 509190000154 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190000155 putative active site [active] 509190000156 heme pocket [chemical binding]; other site 509190000157 PAS fold; Region: PAS_3; pfam08447 509190000158 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190000159 putative active site [active] 509190000160 heme pocket [chemical binding]; other site 509190000161 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190000162 PAS domain; Region: PAS_9; pfam13426 509190000163 putative active site [active] 509190000164 heme pocket [chemical binding]; other site 509190000165 PAS fold; Region: PAS_3; pfam08447 509190000166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190000167 dimer interface [polypeptide binding]; other site 509190000168 phosphorylation site [posttranslational modification] 509190000169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190000170 ATP binding site [chemical binding]; other site 509190000171 Mg2+ binding site [ion binding]; other site 509190000172 G-X-G motif; other site 509190000173 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 509190000174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190000175 active site 509190000176 phosphorylation site [posttranslational modification] 509190000177 intermolecular recognition site; other site 509190000178 dimerization interface [polypeptide binding]; other site 509190000179 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 509190000180 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 509190000181 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 509190000182 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 509190000183 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 509190000184 catalytic loop [active] 509190000185 iron binding site [ion binding]; other site 509190000186 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 509190000187 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 509190000188 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 509190000189 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 509190000190 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 509190000191 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 509190000192 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 509190000193 Ligand binding site; other site 509190000194 metal-binding site 509190000195 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 509190000196 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509190000197 FeS/SAM binding site; other site 509190000198 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 509190000199 Ubiquitin-like proteins; Region: UBQ; cl00155 509190000200 charged pocket; other site 509190000201 hydrophobic patch; other site 509190000202 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 509190000203 MoaE homodimer interface [polypeptide binding]; other site 509190000204 MoaD interaction [polypeptide binding]; other site 509190000205 active site residues [active] 509190000206 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 509190000207 MPT binding site; other site 509190000208 trimer interface [polypeptide binding]; other site 509190000209 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 509190000210 trimer interface [polypeptide binding]; other site 509190000211 dimer interface [polypeptide binding]; other site 509190000212 putative active site [active] 509190000213 HAMP domain; Region: HAMP; pfam00672 509190000214 dimerization interface [polypeptide binding]; other site 509190000215 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 509190000216 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190000217 dimer interface [polypeptide binding]; other site 509190000218 putative CheW interface [polypeptide binding]; other site 509190000219 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 509190000220 iron-sulfur cluster [ion binding]; other site 509190000221 [2Fe-2S] cluster binding site [ion binding]; other site 509190000222 YCII-related domain; Region: YCII; cl00999 509190000223 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 509190000224 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 509190000225 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 509190000226 UGMP family protein; Validated; Region: PRK09604 509190000227 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 509190000228 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 509190000229 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 509190000230 domain interfaces; other site 509190000231 active site 509190000232 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 509190000233 active site 509190000234 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 509190000235 HemY protein N-terminus; Region: HemY_N; pfam07219 509190000236 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 509190000237 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 509190000238 dimer interface [polypeptide binding]; other site 509190000239 active site 509190000240 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509190000241 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509190000242 active site 509190000243 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 509190000244 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 509190000245 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509190000246 active site 509190000247 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 509190000248 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 509190000249 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 509190000250 DNA binding residues [nucleotide binding] 509190000251 putative dimer interface [polypeptide binding]; other site 509190000252 Predicted transcriptional regulator [Transcription]; Region: COG2932 509190000253 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 509190000254 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 509190000255 Catalytic site [active] 509190000256 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 509190000257 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 509190000258 active site 509190000259 nucleotide binding site [chemical binding]; other site 509190000260 HIGH motif; other site 509190000261 KMSKS motif; other site 509190000262 phosphoglucomutase; Validated; Region: PRK07564 509190000263 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 509190000264 active site 509190000265 substrate binding site [chemical binding]; other site 509190000266 metal binding site [ion binding]; metal-binding site 509190000267 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 509190000268 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 509190000269 purine monophosphate binding site [chemical binding]; other site 509190000270 dimer interface [polypeptide binding]; other site 509190000271 putative catalytic residues [active] 509190000272 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 509190000273 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 509190000274 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 509190000275 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509190000276 Predicted membrane protein [Function unknown]; Region: COG2311 509190000277 Protein of unknown function (DUF418); Region: DUF418; cl12135 509190000278 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 509190000279 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 509190000280 Domain of unknown function DUF20; Region: UPF0118; pfam01594 509190000281 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 509190000282 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 509190000283 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 509190000284 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 509190000285 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 509190000286 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 509190000287 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190000288 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 509190000289 NAD(P) binding site [chemical binding]; other site 509190000290 active site 509190000291 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 509190000292 EamA-like transporter family; Region: EamA; pfam00892 509190000293 EamA-like transporter family; Region: EamA; pfam00892 509190000294 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 509190000295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190000296 NAD(P) binding site [chemical binding]; other site 509190000297 active site 509190000298 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 509190000299 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 509190000300 NAD(P) binding site [chemical binding]; other site 509190000301 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 509190000302 catalytic nucleophile [active] 509190000303 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 509190000304 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 509190000305 conserved cys residue [active] 509190000306 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190000307 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190000308 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 509190000309 Divergent AAA domain; Region: AAA_4; pfam04326 509190000310 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 509190000311 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 509190000312 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 509190000313 substrate binding site [chemical binding]; other site 509190000314 hexamer interface [polypeptide binding]; other site 509190000315 metal binding site [ion binding]; metal-binding site 509190000316 NusB family; Region: NusB; pfam01029 509190000317 putative RNA binding site [nucleotide binding]; other site 509190000318 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 509190000319 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 509190000320 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 509190000321 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 509190000322 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 509190000323 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 509190000324 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509190000325 motif II; other site 509190000326 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 509190000327 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 509190000328 active site 509190000329 dimer interface [polypeptide binding]; other site 509190000330 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 509190000331 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 509190000332 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 509190000333 Uncharacterized conserved protein [Function unknown]; Region: COG2835 509190000334 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 509190000335 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 509190000336 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 509190000337 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 509190000338 putative deacylase active site [active] 509190000339 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 509190000340 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 509190000341 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 509190000342 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 509190000343 Amidohydrolase; Region: Amidohydro_4; pfam13147 509190000344 active site 509190000345 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 509190000346 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 509190000347 active site 509190000348 substrate binding site [chemical binding]; other site 509190000349 metal binding site [ion binding]; metal-binding site 509190000350 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 509190000351 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 509190000352 glutaminase active site [active] 509190000353 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 509190000354 dimer interface [polypeptide binding]; other site 509190000355 active site 509190000356 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 509190000357 dimer interface [polypeptide binding]; other site 509190000358 active site 509190000359 amino acid transporter; Region: 2A0306; TIGR00909 509190000360 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 509190000361 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 509190000362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190000363 S-adenosylmethionine binding site [chemical binding]; other site 509190000364 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 509190000365 homodimer interaction site [polypeptide binding]; other site 509190000366 cofactor binding site; other site 509190000367 Uncharacterized conserved protein [Function unknown]; Region: COG3339 509190000368 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 509190000369 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 509190000370 NAD binding site [chemical binding]; other site 509190000371 homodimer interface [polypeptide binding]; other site 509190000372 homotetramer interface [polypeptide binding]; other site 509190000373 active site 509190000374 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 509190000375 MAPEG family; Region: MAPEG; pfam01124 509190000376 KTSC domain; Region: KTSC; pfam13619 509190000377 argininosuccinate synthase; Provisional; Region: PRK13820 509190000378 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 509190000379 ANP binding site [chemical binding]; other site 509190000380 Substrate Binding Site II [chemical binding]; other site 509190000381 Substrate Binding Site I [chemical binding]; other site 509190000382 Transcriptional regulator; Region: Rrf2; pfam02082 509190000383 Rrf2 family protein; Region: rrf2_super; TIGR00738 509190000384 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 509190000385 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 509190000386 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 509190000387 Malic enzyme, N-terminal domain; Region: malic; pfam00390 509190000388 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 509190000389 putative NAD(P) binding site [chemical binding]; other site 509190000390 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 509190000391 dihydrodipicolinate reductase; Provisional; Region: PRK00048 509190000392 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 509190000393 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 509190000394 Dicarboxylate transport; Region: DctA-YdbH; cl14674 509190000395 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 509190000396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 509190000397 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190000398 PAS domain; Region: PAS_9; pfam13426 509190000399 putative active site [active] 509190000400 heme pocket [chemical binding]; other site 509190000401 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 509190000402 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190000403 dimer interface [polypeptide binding]; other site 509190000404 putative CheW interface [polypeptide binding]; other site 509190000405 Transcriptional regulators [Transcription]; Region: MarR; COG1846 509190000406 MarR family; Region: MarR; pfam01047 509190000407 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 509190000408 Usg-like family; Region: Usg; pfam06233 509190000409 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 509190000410 active site 509190000411 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 509190000412 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 509190000413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190000414 catalytic residue [active] 509190000415 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 509190000416 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 509190000417 substrate binding site [chemical binding]; other site 509190000418 active site 509190000419 catalytic residues [active] 509190000420 heterodimer interface [polypeptide binding]; other site 509190000421 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 509190000422 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 509190000423 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 509190000424 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 509190000425 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 509190000426 catalytic residues [active] 509190000427 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 509190000428 Part of AAA domain; Region: AAA_19; pfam13245 509190000429 Family description; Region: UvrD_C_2; pfam13538 509190000430 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 509190000431 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 509190000432 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 509190000433 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 509190000434 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 509190000435 Substrate binding site; other site 509190000436 metal-binding site 509190000437 Phosphotransferase enzyme family; Region: APH; pfam01636 509190000438 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 509190000439 substrate binding site [chemical binding]; other site 509190000440 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 509190000441 Predicted ATPase [General function prediction only]; Region: COG1485 509190000442 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 509190000443 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 509190000444 dimer interface [polypeptide binding]; other site 509190000445 ADP-ribose binding site [chemical binding]; other site 509190000446 active site 509190000447 nudix motif; other site 509190000448 metal binding site [ion binding]; metal-binding site 509190000449 PAS domain; Region: PAS; smart00091 509190000450 PAS fold; Region: PAS_4; pfam08448 509190000451 putative active site [active] 509190000452 heme pocket [chemical binding]; other site 509190000453 PAS fold; Region: PAS_4; pfam08448 509190000454 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 509190000455 HWE histidine kinase; Region: HWE_HK; pfam07536 509190000456 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 509190000457 Iron-sulfur protein interface; other site 509190000458 proximal quinone binding site [chemical binding]; other site 509190000459 SdhD (CybS) interface [polypeptide binding]; other site 509190000460 proximal heme binding site [chemical binding]; other site 509190000461 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 509190000462 putative SdhC subunit interface [polypeptide binding]; other site 509190000463 putative proximal heme binding site [chemical binding]; other site 509190000464 putative Iron-sulfur protein interface [polypeptide binding]; other site 509190000465 putative proximal quinone binding site; other site 509190000466 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 509190000467 L-aspartate oxidase; Provisional; Region: PRK06175 509190000468 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 509190000469 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 509190000470 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 509190000471 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 509190000472 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 509190000473 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509190000474 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 509190000475 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 509190000476 catalytic loop [active] 509190000477 iron binding site [ion binding]; other site 509190000478 Uncharacterized conserved protein [Function unknown]; Region: COG3025 509190000479 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 509190000480 putative active site [active] 509190000481 putative metal binding residues [ion binding]; other site 509190000482 signature motif; other site 509190000483 putative triphosphate binding site [ion binding]; other site 509190000484 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 509190000485 Biotin synthase and related enzymes [Coenzyme metabolism]; Region: BioB; COG0502 509190000486 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509190000487 FeS/SAM binding site; other site 509190000488 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 509190000489 Hemerythrin-like domain; Region: Hr-like; cd12108 509190000490 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 509190000491 dimerization domain swap beta strand [polypeptide binding]; other site 509190000492 regulatory protein interface [polypeptide binding]; other site 509190000493 active site 509190000494 regulatory phosphorylation site [posttranslational modification]; other site 509190000495 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 509190000496 active pocket/dimerization site; other site 509190000497 active site 509190000498 phosphorylation site [posttranslational modification] 509190000499 Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493 509190000500 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 509190000501 Hpr binding site; other site 509190000502 active site 509190000503 homohexamer subunit interaction site [polypeptide binding]; other site 509190000504 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 509190000505 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 509190000506 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509190000507 HAMP domain; Region: HAMP; pfam00672 509190000508 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190000509 dimer interface [polypeptide binding]; other site 509190000510 phosphorylation site [posttranslational modification] 509190000511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190000512 ATP binding site [chemical binding]; other site 509190000513 Mg2+ binding site [ion binding]; other site 509190000514 G-X-G motif; other site 509190000515 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 509190000516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190000517 active site 509190000518 phosphorylation site [posttranslational modification] 509190000519 intermolecular recognition site; other site 509190000520 dimerization interface [polypeptide binding]; other site 509190000521 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509190000522 DNA binding site [nucleotide binding] 509190000523 EthD domain; Region: EthD; cl17553 509190000524 Response regulator receiver domain; Region: Response_reg; pfam00072 509190000525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190000526 active site 509190000527 phosphorylation site [posttranslational modification] 509190000528 intermolecular recognition site; other site 509190000529 dimerization interface [polypeptide binding]; other site 509190000530 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 509190000531 GAF domain; Region: GAF; pfam01590 509190000532 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 509190000533 HWE histidine kinase; Region: HWE_HK; pfam07536 509190000534 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 509190000535 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 509190000536 inhibitor-cofactor binding pocket; inhibition site 509190000537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190000538 catalytic residue [active] 509190000539 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 509190000540 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 509190000541 NAD(P) binding site [chemical binding]; other site 509190000542 homodimer interface [polypeptide binding]; other site 509190000543 substrate binding site [chemical binding]; other site 509190000544 active site 509190000545 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 509190000546 nucleoside/Zn binding site; other site 509190000547 dimer interface [polypeptide binding]; other site 509190000548 catalytic motif [active] 509190000549 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 509190000550 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509190000551 RNA binding surface [nucleotide binding]; other site 509190000552 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 509190000553 probable active site [active] 509190000554 CAAX protease self-immunity; Region: Abi; pfam02517 509190000555 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 509190000556 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 509190000557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190000558 S-adenosylmethionine binding site [chemical binding]; other site 509190000559 hypothetical protein; Provisional; Region: PRK13687 509190000560 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 509190000561 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 509190000562 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 509190000563 epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247 509190000564 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509190000565 motif II; other site 509190000566 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 509190000567 aromatic arch; other site 509190000568 DCoH dimer interaction site [polypeptide binding]; other site 509190000569 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 509190000570 DCoH tetramer interaction site [polypeptide binding]; other site 509190000571 substrate binding site [chemical binding]; other site 509190000572 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190000573 short chain dehydrogenase; Validated; Region: PRK07069 509190000574 NAD(P) binding site [chemical binding]; other site 509190000575 active site 509190000576 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 509190000577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190000578 active site 509190000579 phosphorylation site [posttranslational modification] 509190000580 intermolecular recognition site; other site 509190000581 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 509190000582 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509190000583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190000584 ATP binding site [chemical binding]; other site 509190000585 Mg2+ binding site [ion binding]; other site 509190000586 G-X-G motif; other site 509190000587 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 509190000588 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 509190000589 Cu(I) binding site [ion binding]; other site 509190000590 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 509190000591 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 509190000592 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 509190000593 Transglycosylase; Region: Transgly; pfam00912 509190000594 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 509190000595 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 509190000596 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 509190000597 SdpI/YhfL protein family; Region: SdpI; pfam13630 509190000598 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509190000599 dimerization interface [polypeptide binding]; other site 509190000600 putative DNA binding site [nucleotide binding]; other site 509190000601 putative Zn2+ binding site [ion binding]; other site 509190000602 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 509190000603 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509190000604 ATP binding site [chemical binding]; other site 509190000605 putative Mg++ binding site [ion binding]; other site 509190000606 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509190000607 nucleotide binding region [chemical binding]; other site 509190000608 ATP-binding site [chemical binding]; other site 509190000609 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 509190000610 HRDC domain; Region: HRDC; pfam00570 509190000611 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 509190000612 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509190000613 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 509190000614 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 509190000615 MarR family; Region: MarR; pfam01047 509190000616 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 509190000617 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 509190000618 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 509190000619 dinuclear metal binding motif [ion binding]; other site 509190000620 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 509190000621 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190000622 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509190000623 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190000624 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190000625 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509190000626 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190000627 SWIM zinc finger; Region: SWIM; pfam04434 509190000628 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 509190000629 PAS fold; Region: PAS_7; pfam12860 509190000630 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 509190000631 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190000632 dimer interface [polypeptide binding]; other site 509190000633 phosphorylation site [posttranslational modification] 509190000634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190000635 ATP binding site [chemical binding]; other site 509190000636 Mg2+ binding site [ion binding]; other site 509190000637 G-X-G motif; other site 509190000638 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 509190000639 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 509190000640 homotetramer interface [polypeptide binding]; other site 509190000641 ligand binding site [chemical binding]; other site 509190000642 catalytic site [active] 509190000643 NAD binding site [chemical binding]; other site 509190000644 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 509190000645 ATP binding site [chemical binding]; other site 509190000646 substrate binding site [chemical binding]; other site 509190000647 Predicted permeases [General function prediction only]; Region: RarD; COG2962 509190000648 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 509190000649 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 509190000650 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 509190000651 Gram-negative bacterial tonB protein; Region: TonB; cl10048 509190000652 DNA polymerase I; Provisional; Region: PRK05755 509190000653 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 509190000654 active site 509190000655 metal binding site 1 [ion binding]; metal-binding site 509190000656 putative 5' ssDNA interaction site; other site 509190000657 metal binding site 3; metal-binding site 509190000658 metal binding site 2 [ion binding]; metal-binding site 509190000659 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 509190000660 putative DNA binding site [nucleotide binding]; other site 509190000661 putative metal binding site [ion binding]; other site 509190000662 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 509190000663 active site 509190000664 catalytic site [active] 509190000665 substrate binding site [chemical binding]; other site 509190000666 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 509190000667 active site 509190000668 DNA binding site [nucleotide binding] 509190000669 catalytic site [active] 509190000670 CHASE3 domain; Region: CHASE3; cl05000 509190000671 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 509190000672 dimerization interface [polypeptide binding]; other site 509190000673 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 509190000674 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190000675 dimer interface [polypeptide binding]; other site 509190000676 putative CheW interface [polypeptide binding]; other site 509190000677 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 509190000678 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 509190000679 dimer interface [polypeptide binding]; other site 509190000680 active site 509190000681 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190000682 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190000683 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190000684 Predicted membrane protein [Function unknown]; Region: COG3762 509190000685 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 509190000686 Repair protein; Region: Repair_PSII; pfam04536 509190000687 LemA family; Region: LemA; pfam04011 509190000688 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 509190000689 PHB binding site; other site 509190000690 CoenzymeA binding site [chemical binding]; other site 509190000691 subunit interaction site [polypeptide binding]; other site 509190000692 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712 509190000693 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 509190000694 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 509190000695 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 509190000696 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 509190000697 beta subunit interaction interface [polypeptide binding]; other site 509190000698 Walker A motif; other site 509190000699 ATP binding site [chemical binding]; other site 509190000700 Walker B motif; other site 509190000701 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 509190000702 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 509190000703 core domain interface [polypeptide binding]; other site 509190000704 delta subunit interface [polypeptide binding]; other site 509190000705 epsilon subunit interface [polypeptide binding]; other site 509190000706 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 509190000707 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 509190000708 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 509190000709 alpha subunit interaction interface [polypeptide binding]; other site 509190000710 Walker A motif; other site 509190000711 ATP binding site [chemical binding]; other site 509190000712 Walker B motif; other site 509190000713 inhibitor binding site; inhibition site 509190000714 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 509190000715 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 509190000716 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 509190000717 gamma subunit interface [polypeptide binding]; other site 509190000718 epsilon subunit interface [polypeptide binding]; other site 509190000719 LBP interface [polypeptide binding]; other site 509190000720 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 509190000721 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509190000722 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 509190000723 PGAP1-like protein; Region: PGAP1; pfam07819 509190000724 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509190000725 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 509190000726 putative active site [active] 509190000727 Ap4A binding site [chemical binding]; other site 509190000728 nudix motif; other site 509190000729 putative metal binding site [ion binding]; other site 509190000730 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 509190000731 NodB motif; other site 509190000732 putative active site [active] 509190000733 putative catalytic site [active] 509190000734 Zn binding site [ion binding]; other site 509190000735 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 509190000736 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 509190000737 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 509190000738 protein binding site [polypeptide binding]; other site 509190000739 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 509190000740 Catalytic dyad [active] 509190000741 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 509190000742 Peptidase family M23; Region: Peptidase_M23; pfam01551 509190000743 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 509190000744 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 509190000745 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 509190000746 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 509190000747 active site 509190000748 (T/H)XGH motif; other site 509190000749 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 509190000750 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 509190000751 putative catalytic cysteine [active] 509190000752 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509190000753 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190000754 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190000755 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 509190000756 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 509190000757 active site 509190000758 catalytic tetrad [active] 509190000759 Protein of unknown function (DUF419); Region: DUF419; cl15265 509190000760 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190000761 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 509190000762 NAD(P) binding site [chemical binding]; other site 509190000763 active site 509190000764 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 509190000765 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 509190000766 Predicted methyltransferase [General function prediction only]; Region: COG3897 509190000767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 509190000768 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 509190000769 Fatty acid desaturase; Region: FA_desaturase; pfam00487 509190000770 putative di-iron ligands [ion binding]; other site 509190000771 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 509190000772 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 509190000773 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 509190000774 UbiA prenyltransferase family; Region: UbiA; pfam01040 509190000775 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 509190000776 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 509190000777 tetramer interface [polypeptide binding]; other site 509190000778 heme binding pocket [chemical binding]; other site 509190000779 NADPH binding site [chemical binding]; other site 509190000780 Isochorismatase family; Region: Isochorismatase; pfam00857 509190000781 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 509190000782 catalytic triad [active] 509190000783 conserved cis-peptide bond; other site 509190000784 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 509190000785 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 509190000786 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 509190000787 Walker A/P-loop; other site 509190000788 ATP binding site [chemical binding]; other site 509190000789 Q-loop/lid; other site 509190000790 ABC transporter signature motif; other site 509190000791 Walker B; other site 509190000792 D-loop; other site 509190000793 H-loop/switch region; other site 509190000794 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 509190000795 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 509190000796 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 509190000797 Uncharacterized conserved protein [Function unknown]; Region: COG5646 509190000798 Uncharacterized conserved protein [Function unknown]; Region: COG2326 509190000799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 509190000800 RNA methyltransferase, RsmE family; Region: TIGR00046 509190000801 glutamate--cysteine ligase; Region: PLN02611 509190000802 Domain of unknown function (DUF427); Region: DUF427; pfam04248 509190000803 POT family; Region: PTR2; cl17359 509190000804 POT family; Region: PTR2; cl17359 509190000805 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 509190000806 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 509190000807 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 509190000808 Predicted membrane protein [Function unknown]; Region: COG4709 509190000809 Predicted transcriptional regulators [Transcription]; Region: COG1695 509190000810 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 509190000811 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154 509190000812 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 509190000813 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 509190000814 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 509190000815 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 509190000816 Subunit I/III interface [polypeptide binding]; other site 509190000817 D-pathway; other site 509190000818 Subunit I/VIIc interface [polypeptide binding]; other site 509190000819 Subunit I/IV interface [polypeptide binding]; other site 509190000820 Subunit I/II interface [polypeptide binding]; other site 509190000821 Low-spin heme (heme a) binding site [chemical binding]; other site 509190000822 Subunit I/VIIa interface [polypeptide binding]; other site 509190000823 Subunit I/VIa interface [polypeptide binding]; other site 509190000824 Dimer interface; other site 509190000825 Putative water exit pathway; other site 509190000826 Binuclear center (heme a3/CuB) [ion binding]; other site 509190000827 K-pathway; other site 509190000828 Subunit I/Vb interface [polypeptide binding]; other site 509190000829 Putative proton exit pathway; other site 509190000830 Subunit I/VIb interface; other site 509190000831 Subunit I/VIc interface [polypeptide binding]; other site 509190000832 Electron transfer pathway; other site 509190000833 Subunit I/VIIIb interface [polypeptide binding]; other site 509190000834 Subunit I/VIIb interface [polypeptide binding]; other site 509190000835 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 509190000836 UbiA prenyltransferase family; Region: UbiA; pfam01040 509190000837 Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175 509190000838 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 509190000839 Subunit III/VIIa interface [polypeptide binding]; other site 509190000840 Phospholipid binding site [chemical binding]; other site 509190000841 Subunit I/III interface [polypeptide binding]; other site 509190000842 Subunit III/VIb interface [polypeptide binding]; other site 509190000843 Subunit III/VIa interface; other site 509190000844 Subunit III/Vb interface [polypeptide binding]; other site 509190000845 Protein of unknown function (DUF983); Region: DUF983; cl02211 509190000846 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 509190000847 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 509190000848 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 509190000849 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 509190000850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 509190000851 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 509190000852 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 509190000853 metal binding site [ion binding]; metal-binding site 509190000854 active site 509190000855 I-site; other site 509190000856 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 509190000857 Putative transcriptional regulator [Transcription]; Region: COG1678 509190000858 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 509190000859 catalytic triad [active] 509190000860 dimer interface [polypeptide binding]; other site 509190000861 Transcriptional regulators [Transcription]; Region: MarR; COG1846 509190000862 MarR family; Region: MarR; pfam01047 509190000863 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 509190000864 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 509190000865 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509190000866 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509190000867 active site 509190000868 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 509190000869 Uncharacterized conserved protein [Function unknown]; Region: COG2353 509190000870 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 509190000871 YceI-like domain; Region: YceI; pfam04264 509190000872 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 509190000873 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 509190000874 Transcriptional regulators [Transcription]; Region: MarR; COG1846 509190000875 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509190000876 putative DNA binding site [nucleotide binding]; other site 509190000877 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 509190000878 hypothetical protein; Validated; Region: PRK02101 509190000879 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190000880 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 509190000881 NAD(P) binding site [chemical binding]; other site 509190000882 active site 509190000883 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 509190000884 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 509190000885 active site 509190000886 nucleophile elbow; other site 509190000887 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 509190000888 nudix motif; other site 509190000889 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 509190000890 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 509190000891 active site 509190000892 putative substrate binding region [chemical binding]; other site 509190000893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190000894 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 509190000895 NAD(P) binding site [chemical binding]; other site 509190000896 active site 509190000897 Predicted transcriptional regulators [Transcription]; Region: COG1733 509190000898 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 509190000899 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509190000900 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 509190000901 C-terminal domain interface [polypeptide binding]; other site 509190000902 GSH binding site (G-site) [chemical binding]; other site 509190000903 dimer interface [polypeptide binding]; other site 509190000904 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 509190000905 N-terminal domain interface [polypeptide binding]; other site 509190000906 dimer interface [polypeptide binding]; other site 509190000907 substrate binding pocket (H-site) [chemical binding]; other site 509190000908 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 509190000909 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 509190000910 FMN binding site [chemical binding]; other site 509190000911 substrate binding site [chemical binding]; other site 509190000912 putative catalytic residue [active] 509190000913 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 509190000914 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 509190000915 putative switch regulator; other site 509190000916 non-specific DNA interactions [nucleotide binding]; other site 509190000917 DNA binding site [nucleotide binding] 509190000918 sequence specific DNA binding site [nucleotide binding]; other site 509190000919 putative cAMP binding site [chemical binding]; other site 509190000920 Protein of unknown function (DUF2385); Region: DUF2385; cl11490 509190000921 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 509190000922 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 509190000923 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 509190000924 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 509190000925 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 509190000926 Walker A/P-loop; other site 509190000927 ATP binding site [chemical binding]; other site 509190000928 Q-loop/lid; other site 509190000929 ABC transporter signature motif; other site 509190000930 Walker B; other site 509190000931 D-loop; other site 509190000932 H-loop/switch region; other site 509190000933 ABC-2 type transporter; Region: ABC2_membrane; cl17235 509190000934 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 509190000935 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 509190000936 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 509190000937 catalytic residues [active] 509190000938 catalytic nucleophile [active] 509190000939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190000940 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 509190000941 NAD(P) binding site [chemical binding]; other site 509190000942 active site 509190000943 Predicted transcriptional regulators [Transcription]; Region: COG1733 509190000944 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 509190000945 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 509190000946 RNA/DNA hybrid binding site [nucleotide binding]; other site 509190000947 active site 509190000948 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 509190000949 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 509190000950 putative active site [active] 509190000951 putative substrate binding site [chemical binding]; other site 509190000952 ATP binding site [chemical binding]; other site 509190000953 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 509190000954 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 509190000955 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 509190000956 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 509190000957 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 509190000958 active site 509190000959 HIGH motif; other site 509190000960 nucleotide binding site [chemical binding]; other site 509190000961 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 509190000962 KMSK motif region; other site 509190000963 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 509190000964 tRNA binding surface [nucleotide binding]; other site 509190000965 anticodon binding site; other site 509190000966 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 509190000967 dimerization interface [polypeptide binding]; other site 509190000968 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 509190000969 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190000970 dimer interface [polypeptide binding]; other site 509190000971 putative CheW interface [polypeptide binding]; other site 509190000972 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 509190000973 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 509190000974 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 509190000975 lipoyl attachment site [posttranslational modification]; other site 509190000976 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 509190000977 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 509190000978 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509190000979 catalytic residue [active] 509190000980 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 509190000981 tetramer interface [polypeptide binding]; other site 509190000982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190000983 catalytic residue [active] 509190000984 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509190000985 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 509190000986 C-terminal domain interface [polypeptide binding]; other site 509190000987 GSH binding site (G-site) [chemical binding]; other site 509190000988 dimer interface [polypeptide binding]; other site 509190000989 F0F1 ATP synthase subunit B; Provisional; Region: PRK14475 509190000990 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 509190000991 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 509190000992 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 509190000993 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 509190000994 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 509190000995 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 509190000996 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 509190000997 hypothetical protein; Provisional; Region: PRK10621 509190000998 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 509190000999 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 509190001000 Walker A/P-loop; other site 509190001001 ATP binding site [chemical binding]; other site 509190001002 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 509190001003 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 509190001004 ABC transporter signature motif; other site 509190001005 Walker B; other site 509190001006 D-loop; other site 509190001007 H-loop/switch region; other site 509190001008 Thioredoxin; Region: Thioredoxin_4; pfam13462 509190001009 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 509190001010 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 509190001011 Thioredoxin; Region: Thioredoxin_4; pfam13462 509190001012 Protein of unknown function (DUF721); Region: DUF721; cl02324 509190001013 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 509190001014 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 509190001015 minor groove reading motif; other site 509190001016 helix-hairpin-helix signature motif; other site 509190001017 substrate binding pocket [chemical binding]; other site 509190001018 active site 509190001019 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 509190001020 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 509190001021 DNA binding and oxoG recognition site [nucleotide binding] 509190001022 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 509190001023 DNA methylase; Region: N6_N4_Mtase; pfam01555 509190001024 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 509190001025 RNA/DNA hybrid binding site [nucleotide binding]; other site 509190001026 active site 509190001027 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 509190001028 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 509190001029 active site 509190001030 catalytic residues [active] 509190001031 Cytochrome b [Energy production and conversion]; Region: COG3658 509190001032 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 509190001033 DNA binding residues [nucleotide binding] 509190001034 H+ Antiporter protein; Region: 2A0121; TIGR00900 509190001035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190001036 putative substrate translocation pore; other site 509190001037 Cupin domain; Region: Cupin_2; pfam07883 509190001038 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 509190001039 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 509190001040 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 509190001041 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 509190001042 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 509190001043 putative active site [active] 509190001044 dihydroorotase; Validated; Region: PRK09060 509190001045 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 509190001046 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 509190001047 active site 509190001048 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 509190001049 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 509190001050 YCII-related domain; Region: YCII; cl00999 509190001051 feruloyl-CoA synthase; Reviewed; Region: PRK08180 509190001052 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 509190001053 acyl-activating enzyme (AAE) consensus motif; other site 509190001054 putative AMP binding site [chemical binding]; other site 509190001055 putative active site [active] 509190001056 putative CoA binding site [chemical binding]; other site 509190001057 YhhN-like protein; Region: YhhN; pfam07947 509190001058 hypothetical protein; Validated; Region: PRK07586 509190001059 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 509190001060 PYR/PP interface [polypeptide binding]; other site 509190001061 dimer interface [polypeptide binding]; other site 509190001062 TPP binding site [chemical binding]; other site 509190001063 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 509190001064 TPP-binding site [chemical binding]; other site 509190001065 dimer interface [polypeptide binding]; other site 509190001066 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 509190001067 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 509190001068 MarR family; Region: MarR_2; pfam12802 509190001069 enoyl-CoA hydratase; Provisional; Region: PRK06688 509190001070 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509190001071 substrate binding site [chemical binding]; other site 509190001072 oxyanion hole (OAH) forming residues; other site 509190001073 trimer interface [polypeptide binding]; other site 509190001074 oxidoreductase; Provisional; Region: PRK06196 509190001075 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 509190001076 putative NAD(P) binding site [chemical binding]; other site 509190001077 active site 509190001078 short chain dehydrogenase; Provisional; Region: PRK08278 509190001079 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 509190001080 NAD(P) binding site [chemical binding]; other site 509190001081 homodimer interface [polypeptide binding]; other site 509190001082 active site 509190001083 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 509190001084 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 509190001085 enterobactin exporter EntS; Provisional; Region: PRK10489 509190001086 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509190001087 Coenzyme A binding pocket [chemical binding]; other site 509190001088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 509190001089 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 509190001090 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 509190001091 putative active site [active] 509190001092 putative CoA binding site [chemical binding]; other site 509190001093 nudix motif; other site 509190001094 metal binding site [ion binding]; metal-binding site 509190001095 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 509190001096 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 509190001097 active site 509190001098 NTP binding site [chemical binding]; other site 509190001099 metal binding triad [ion binding]; metal-binding site 509190001100 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 509190001101 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 509190001102 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 509190001103 catalytic triad [active] 509190001104 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190001105 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190001106 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 509190001107 Methyltransferase domain; Region: Methyltransf_24; pfam13578 509190001108 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 509190001109 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 509190001110 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 509190001111 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 509190001112 dimer interface [polypeptide binding]; other site 509190001113 active site 509190001114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 509190001115 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 509190001116 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 509190001117 putative acyltransferase; Provisional; Region: PRK05790 509190001118 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 509190001119 dimer interface [polypeptide binding]; other site 509190001120 active site 509190001121 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 509190001122 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 509190001123 NAD(P) binding site [chemical binding]; other site 509190001124 homotetramer interface [polypeptide binding]; other site 509190001125 homodimer interface [polypeptide binding]; other site 509190001126 active site 509190001127 Transcriptional regulators [Transcription]; Region: PurR; COG1609 509190001128 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 509190001129 DNA binding site [nucleotide binding] 509190001130 domain linker motif; other site 509190001131 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 509190001132 putative dimerization interface [polypeptide binding]; other site 509190001133 putative ligand binding site [chemical binding]; other site 509190001134 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 509190001135 non-specific DNA interactions [nucleotide binding]; other site 509190001136 DNA binding site [nucleotide binding] 509190001137 sequence specific DNA binding site [nucleotide binding]; other site 509190001138 putative cAMP binding site [chemical binding]; other site 509190001139 Uncharacterized conserved protein [Function unknown]; Region: COG3542 509190001140 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 509190001141 Methyltransferase domain; Region: Methyltransf_23; pfam13489 509190001142 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 509190001143 Nitrogen regulatory protein P-II; Region: P-II; smart00938 509190001144 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 509190001145 putative active site [active] 509190001146 catalytic site [active] 509190001147 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 509190001148 PLD-like domain; Region: PLDc_2; pfam13091 509190001149 putative active site [active] 509190001150 catalytic site [active] 509190001151 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 509190001152 putative catalytic site [active] 509190001153 putative metal binding site [ion binding]; other site 509190001154 putative phosphate binding site [ion binding]; other site 509190001155 Methyltransferase domain; Region: Methyltransf_23; pfam13489 509190001156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190001157 S-adenosylmethionine binding site [chemical binding]; other site 509190001158 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 509190001159 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 509190001160 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 509190001161 catalytic core [active] 509190001162 Protein of unknown function (DUF952); Region: DUF952; cl01393 509190001163 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 509190001164 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 509190001165 quinone interaction residues [chemical binding]; other site 509190001166 active site 509190001167 catalytic residues [active] 509190001168 FMN binding site [chemical binding]; other site 509190001169 substrate binding site [chemical binding]; other site 509190001170 Uncharacterized conserved protein [Function unknown]; Region: COG0398 509190001171 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 509190001172 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509190001173 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 509190001174 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190001175 dimer interface [polypeptide binding]; other site 509190001176 phosphorylation site [posttranslational modification] 509190001177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190001178 ATP binding site [chemical binding]; other site 509190001179 Mg2+ binding site [ion binding]; other site 509190001180 G-X-G motif; other site 509190001181 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 509190001182 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 509190001183 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 509190001184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190001185 active site 509190001186 phosphorylation site [posttranslational modification] 509190001187 intermolecular recognition site; other site 509190001188 dimerization interface [polypeptide binding]; other site 509190001189 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509190001190 DNA binding site [nucleotide binding] 509190001191 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509190001192 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 509190001193 dimerization interface [polypeptide binding]; other site 509190001194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190001195 dimer interface [polypeptide binding]; other site 509190001196 phosphorylation site [posttranslational modification] 509190001197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190001198 ATP binding site [chemical binding]; other site 509190001199 Mg2+ binding site [ion binding]; other site 509190001200 G-X-G motif; other site 509190001201 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 509190001202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190001203 active site 509190001204 phosphorylation site [posttranslational modification] 509190001205 intermolecular recognition site; other site 509190001206 dimerization interface [polypeptide binding]; other site 509190001207 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509190001208 DNA binding site [nucleotide binding] 509190001209 Autotransporter beta-domain; Region: Autotransporter; pfam03797 509190001210 RNA polymerase sigma factor; Reviewed; Region: PRK05602 509190001211 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509190001212 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509190001213 DNA binding residues [nucleotide binding] 509190001214 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 509190001215 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 509190001216 flagellin; Provisional; Region: PRK12802 509190001217 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 509190001218 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 509190001219 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 509190001220 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 509190001221 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 509190001222 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 509190001223 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 509190001224 putative metalloprotease; Provisional; Region: PHA03081 509190001225 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 509190001226 Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256 509190001227 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08913 509190001228 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 509190001229 Response regulator receiver domain; Region: Response_reg; pfam00072 509190001230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190001231 active site 509190001232 phosphorylation site [posttranslational modification] 509190001233 intermolecular recognition site; other site 509190001234 dimerization interface [polypeptide binding]; other site 509190001235 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 509190001236 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 509190001237 putative binding surface; other site 509190001238 active site 509190001239 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 509190001240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190001241 ATP binding site [chemical binding]; other site 509190001242 Mg2+ binding site [ion binding]; other site 509190001243 G-X-G motif; other site 509190001244 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 509190001245 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 509190001246 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 509190001247 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 509190001248 dimerization interface [polypeptide binding]; other site 509190001249 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190001250 dimer interface [polypeptide binding]; other site 509190001251 putative CheW interface [polypeptide binding]; other site 509190001252 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 509190001253 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 509190001254 dimerization interface [polypeptide binding]; other site 509190001255 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 509190001256 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 509190001257 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190001258 dimer interface [polypeptide binding]; other site 509190001259 putative CheW interface [polypeptide binding]; other site 509190001260 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 509190001261 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 509190001262 dimerization interface [polypeptide binding]; other site 509190001263 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190001264 dimer interface [polypeptide binding]; other site 509190001265 putative CheW interface [polypeptide binding]; other site 509190001266 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 509190001267 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 509190001268 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 509190001269 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 509190001270 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 509190001271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190001272 active site 509190001273 phosphorylation site [posttranslational modification] 509190001274 intermolecular recognition site; other site 509190001275 dimerization interface [polypeptide binding]; other site 509190001276 CheB methylesterase; Region: CheB_methylest; pfam01339 509190001277 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 509190001278 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 509190001279 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 509190001280 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 509190001281 Walker A/P-loop; other site 509190001282 ATP binding site [chemical binding]; other site 509190001283 Q-loop/lid; other site 509190001284 ABC transporter signature motif; other site 509190001285 Walker B; other site 509190001286 D-loop; other site 509190001287 H-loop/switch region; other site 509190001288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190001289 S-adenosylmethionine binding site [chemical binding]; other site 509190001290 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 509190001291 putative ligand binding site [chemical binding]; other site 509190001292 putative catalytic site [active] 509190001293 Lipopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: RgpF; COG3754 509190001294 Protein of unknown function (DUF563); Region: DUF563; cl15705 509190001295 Protein of unknown function (DUF563); Region: DUF563; cl15705 509190001296 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 509190001297 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 509190001298 HNH endonuclease; Region: HNH_2; pfam13391 509190001299 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 509190001300 additional DNA contacts [nucleotide binding]; other site 509190001301 mismatch recognition site; other site 509190001302 active site 509190001303 zinc binding site [ion binding]; other site 509190001304 DNA intercalation site [nucleotide binding]; other site 509190001305 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 509190001306 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 509190001307 cofactor binding site; other site 509190001308 DNA binding site [nucleotide binding] 509190001309 substrate interaction site [chemical binding]; other site 509190001310 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 509190001311 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509190001312 non-specific DNA binding site [nucleotide binding]; other site 509190001313 salt bridge; other site 509190001314 sequence-specific DNA binding site [nucleotide binding]; other site 509190001315 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 509190001316 DNA binding site [nucleotide binding] 509190001317 active site 509190001318 Int/Topo IB signature motif; other site 509190001319 catalytic residues [active] 509190001320 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190001321 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509190001322 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190001323 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 509190001324 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 509190001325 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 509190001326 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 509190001327 Isochorismatase family; Region: Isochorismatase; pfam00857 509190001328 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 509190001329 catalytic triad [active] 509190001330 conserved cis-peptide bond; other site 509190001331 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 509190001332 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 509190001333 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509190001334 DNA binding site [nucleotide binding] 509190001335 Predicted ATPase [General function prediction only]; Region: COG3903 509190001336 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190001337 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190001338 N-terminal plug; other site 509190001339 ligand-binding site [chemical binding]; other site 509190001340 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 509190001341 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 509190001342 active site 509190001343 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 509190001344 Transcriptional regulators [Transcription]; Region: PurR; COG1609 509190001345 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 509190001346 DNA binding site [nucleotide binding] 509190001347 domain linker motif; other site 509190001348 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 509190001349 putative dimerization interface [polypeptide binding]; other site 509190001350 putative ligand binding site [chemical binding]; other site 509190001351 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190001352 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190001353 N-terminal plug; other site 509190001354 ligand-binding site [chemical binding]; other site 509190001355 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 509190001356 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 509190001357 substrate binding pocket [chemical binding]; other site 509190001358 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 509190001359 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509190001360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190001361 putative substrate translocation pore; other site 509190001362 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509190001363 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 509190001364 Putative esterase; Region: Esterase; pfam00756 509190001365 acetyl esterase; Provisional; Region: PRK10162 509190001366 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509190001367 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 509190001368 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 509190001369 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 509190001370 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190001371 N-terminal plug; other site 509190001372 ligand-binding site [chemical binding]; other site 509190001373 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 509190001374 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 509190001375 substrate binding pocket [chemical binding]; other site 509190001376 catalytic triad [active] 509190001377 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 509190001378 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 509190001379 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 509190001380 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 509190001381 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 509190001382 active site 509190001383 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 509190001384 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 509190001385 active site 509190001386 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190001387 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190001388 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190001389 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190001390 N-terminal plug; other site 509190001391 ligand-binding site [chemical binding]; other site 509190001392 Secretin and TonB N terminus short domain; Region: STN; smart00965 509190001393 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190001394 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190001395 N-terminal plug; other site 509190001396 ligand-binding site [chemical binding]; other site 509190001397 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 509190001398 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509190001399 DNA binding residues [nucleotide binding] 509190001400 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 509190001401 FecR protein; Region: FecR; pfam04773 509190001402 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 509190001403 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509190001404 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 509190001405 DNA binding residues [nucleotide binding] 509190001406 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 509190001407 FecR protein; Region: FecR; pfam04773 509190001408 Secretin and TonB N terminus short domain; Region: STN; smart00965 509190001409 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 509190001410 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190001411 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190001412 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 509190001413 active site 509190001414 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509190001415 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 509190001416 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509190001417 DNA binding residues [nucleotide binding] 509190001418 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 509190001419 FecR protein; Region: FecR; pfam04773 509190001420 Secretin and TonB N terminus short domain; Region: STN; smart00965 509190001421 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 509190001422 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190001423 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190001424 Pectinesterase; Region: Pectinesterase; pfam01095 509190001425 putative pectinesterase; Region: PLN02432; cl01911 509190001426 FecR protein; Region: FecR; pfam04773 509190001427 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 509190001428 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 509190001429 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509190001430 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 509190001431 active site 509190001432 metal binding site [ion binding]; metal-binding site 509190001433 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 509190001434 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 509190001435 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 509190001436 putative active site [active] 509190001437 catalytic site [active] 509190001438 putative metal binding site [ion binding]; other site 509190001439 oligomer interface [polypeptide binding]; other site 509190001440 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 509190001441 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 509190001442 NAD binding site [chemical binding]; other site 509190001443 homodimer interface [polypeptide binding]; other site 509190001444 active site 509190001445 substrate binding site [chemical binding]; other site 509190001446 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 509190001447 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 509190001448 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 509190001449 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 509190001450 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 509190001451 putative glycosyl transferase; Provisional; Region: PRK10307 509190001452 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 509190001453 putative acyl transferase; Provisional; Region: PRK10502 509190001454 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 509190001455 putative trimer interface [polypeptide binding]; other site 509190001456 putative active site [active] 509190001457 putative substrate binding site [chemical binding]; other site 509190001458 putative CoA binding site [chemical binding]; other site 509190001459 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 509190001460 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 509190001461 putative ADP-binding pocket [chemical binding]; other site 509190001462 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 509190001463 active site 509190001464 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 509190001465 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 509190001466 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 509190001467 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 509190001468 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 509190001469 trimer interface [polypeptide binding]; other site 509190001470 active site 509190001471 substrate binding site [chemical binding]; other site 509190001472 CoA binding site [chemical binding]; other site 509190001473 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 509190001474 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 509190001475 NADP binding site [chemical binding]; other site 509190001476 active site 509190001477 putative substrate binding site [chemical binding]; other site 509190001478 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 509190001479 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 509190001480 NADP-binding site; other site 509190001481 homotetramer interface [polypeptide binding]; other site 509190001482 substrate binding site [chemical binding]; other site 509190001483 homodimer interface [polypeptide binding]; other site 509190001484 active site 509190001485 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 509190001486 CoenzymeA binding site [chemical binding]; other site 509190001487 subunit interaction site [polypeptide binding]; other site 509190001488 PHB binding site; other site 509190001489 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 509190001490 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 509190001491 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509190001492 RNA binding surface [nucleotide binding]; other site 509190001493 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 509190001494 active site 509190001495 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190001496 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 509190001497 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190001498 PhoD-like phosphatase; Region: PhoD; pfam09423 509190001499 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 509190001500 putative active site [active] 509190001501 putative metal binding site [ion binding]; other site 509190001502 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 509190001503 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 509190001504 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 509190001505 Protein of unknown function (DUF817); Region: DUF817; pfam05675 509190001506 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 509190001507 GTP cyclohydrolase I; Provisional; Region: PLN03044 509190001508 active site 509190001509 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 509190001510 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 509190001511 active site 509190001512 HIGH motif; other site 509190001513 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 509190001514 KMSKS motif; other site 509190001515 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 509190001516 tRNA binding surface [nucleotide binding]; other site 509190001517 anticodon binding site; other site 509190001518 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 509190001519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190001520 NAD(P) binding site [chemical binding]; other site 509190001521 active site 509190001522 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 509190001523 putative hydrophobic ligand binding site [chemical binding]; other site 509190001524 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 509190001525 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 509190001526 trimerization site [polypeptide binding]; other site 509190001527 active site 509190001528 hypothetical protein; Provisional; Region: PRK14387 509190001529 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 509190001530 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 509190001531 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 509190001532 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 509190001533 active site 509190001534 dimer interface [polypeptide binding]; other site 509190001535 motif 1; other site 509190001536 motif 2; other site 509190001537 motif 3; other site 509190001538 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 509190001539 anticodon binding site; other site 509190001540 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 509190001541 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 509190001542 Probable Catalytic site; other site 509190001543 metal-binding site 509190001544 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 509190001545 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 509190001546 active site 509190001547 catalytic residues [active] 509190001548 metal binding site [ion binding]; metal-binding site 509190001549 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 509190001550 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 509190001551 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 509190001552 Ligand binding site; other site 509190001553 Putative Catalytic site; other site 509190001554 DXD motif; other site 509190001555 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 509190001556 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 509190001557 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 509190001558 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 509190001559 [2Fe-2S] cluster binding site [ion binding]; other site 509190001560 cytochrome b; Provisional; Region: CYTB; MTH00156 509190001561 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 509190001562 Qi binding site; other site 509190001563 intrachain domain interface; other site 509190001564 interchain domain interface [polypeptide binding]; other site 509190001565 heme bH binding site [chemical binding]; other site 509190001566 heme bL binding site [chemical binding]; other site 509190001567 Qo binding site; other site 509190001568 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 509190001569 interchain domain interface [polypeptide binding]; other site 509190001570 intrachain domain interface; other site 509190001571 Qi binding site; other site 509190001572 Qo binding site; other site 509190001573 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 509190001574 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 509190001575 Dienelactone hydrolase family; Region: DLH; pfam01738 509190001576 GTP-binding protein YchF; Reviewed; Region: PRK09601 509190001577 YchF GTPase; Region: YchF; cd01900 509190001578 G1 box; other site 509190001579 GTP/Mg2+ binding site [chemical binding]; other site 509190001580 Switch I region; other site 509190001581 G2 box; other site 509190001582 Switch II region; other site 509190001583 G3 box; other site 509190001584 G4 box; other site 509190001585 G5 box; other site 509190001586 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 509190001587 Pirin-related protein [General function prediction only]; Region: COG1741 509190001588 Pirin; Region: Pirin; pfam02678 509190001589 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 509190001590 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 509190001591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190001592 active site 509190001593 phosphorylation site [posttranslational modification] 509190001594 intermolecular recognition site; other site 509190001595 dimerization interface [polypeptide binding]; other site 509190001596 PAS fold; Region: PAS; pfam00989 509190001597 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190001598 putative active site [active] 509190001599 heme pocket [chemical binding]; other site 509190001600 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 509190001601 Histidine kinase; Region: HisKA_2; pfam07568 509190001602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190001603 ATP binding site [chemical binding]; other site 509190001604 Mg2+ binding site [ion binding]; other site 509190001605 G-X-G motif; other site 509190001606 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509190001607 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 509190001608 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 509190001609 TPR motif; other site 509190001610 binding surface 509190001611 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 509190001612 putative active site [active] 509190001613 catalytic residue [active] 509190001614 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 509190001615 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 509190001616 5S rRNA interface [nucleotide binding]; other site 509190001617 CTC domain interface [polypeptide binding]; other site 509190001618 L16 interface [polypeptide binding]; other site 509190001619 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 509190001620 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 509190001621 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 509190001622 active site 509190001623 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 509190001624 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 509190001625 Uncharacterized conserved protein [Function unknown]; Region: COG1565 509190001626 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 509190001627 Membrane fusogenic activity; Region: BMFP; pfam04380 509190001628 Uncharacterized conserved protein [Function unknown]; Region: COG5465 509190001629 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 509190001630 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 509190001631 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509190001632 HAMP domain; Region: HAMP; pfam00672 509190001633 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190001634 dimer interface [polypeptide binding]; other site 509190001635 phosphorylation site [posttranslational modification] 509190001636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190001637 ATP binding site [chemical binding]; other site 509190001638 Mg2+ binding site [ion binding]; other site 509190001639 G-X-G motif; other site 509190001640 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 509190001641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190001642 active site 509190001643 phosphorylation site [posttranslational modification] 509190001644 intermolecular recognition site; other site 509190001645 dimerization interface [polypeptide binding]; other site 509190001646 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509190001647 DNA binding site [nucleotide binding] 509190001648 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 509190001649 non-specific DNA interactions [nucleotide binding]; other site 509190001650 DNA binding site [nucleotide binding] 509190001651 sequence specific DNA binding site [nucleotide binding]; other site 509190001652 putative cAMP binding site [chemical binding]; other site 509190001653 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 509190001654 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 509190001655 homodimer interface [polypeptide binding]; other site 509190001656 substrate-cofactor binding pocket; other site 509190001657 catalytic residue [active] 509190001658 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 509190001659 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 509190001660 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 509190001661 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190001662 N-terminal plug; other site 509190001663 ligand-binding site [chemical binding]; other site 509190001664 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 509190001665 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 509190001666 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 509190001667 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 509190001668 putative active site [active] 509190001669 catalytic site [active] 509190001670 putative metal binding site [ion binding]; other site 509190001671 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 509190001672 active site 509190001673 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 509190001674 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190001675 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190001676 ligand-binding site [chemical binding]; other site 509190001677 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 509190001678 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 509190001679 catalytic residue [active] 509190001680 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 509190001681 catalytic residues [active] 509190001682 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 509190001683 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509190001684 peroxiredoxin; Region: AhpC; TIGR03137 509190001685 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 509190001686 dimer interface [polypeptide binding]; other site 509190001687 decamer (pentamer of dimers) interface [polypeptide binding]; other site 509190001688 catalytic triad [active] 509190001689 peroxidatic and resolving cysteines [active] 509190001690 Predicted membrane protein [Function unknown]; Region: COG3671 509190001691 Predicted membrane protein [Function unknown]; Region: COG3671 509190001692 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 509190001693 Fasciclin domain; Region: Fasciclin; pfam02469 509190001694 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 509190001695 active site 509190001696 short chain dehydrogenase; Provisional; Region: PRK09134 509190001697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190001698 NAD(P) binding site [chemical binding]; other site 509190001699 active site 509190001700 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 509190001701 nudix motif; other site 509190001702 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 509190001703 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 509190001704 NAD binding site [chemical binding]; other site 509190001705 catalytic residues [active] 509190001706 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 509190001707 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 509190001708 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 509190001709 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 509190001710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190001711 S-adenosylmethionine binding site [chemical binding]; other site 509190001712 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 509190001713 acyl-CoA synthetase; Provisional; Region: PRK12582 509190001714 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 509190001715 acyl-activating enzyme (AAE) consensus motif; other site 509190001716 putative AMP binding site [chemical binding]; other site 509190001717 putative active site [active] 509190001718 putative CoA binding site [chemical binding]; other site 509190001719 M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; Region: M28_Fxna_like; cd03875 509190001720 Peptidase family M28; Region: Peptidase_M28; pfam04389 509190001721 metal binding site [ion binding]; metal-binding site 509190001722 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190001723 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190001724 Uncharacterized conserved protein [Function unknown]; Region: COG0397 509190001725 hypothetical protein; Validated; Region: PRK00029 509190001726 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 509190001727 NodB motif; other site 509190001728 putative active site [active] 509190001729 putative catalytic site [active] 509190001730 putative Zn binding site [ion binding]; other site 509190001731 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 509190001732 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 509190001733 putative metal binding site; other site 509190001734 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190001735 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190001736 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 509190001737 FecR protein; Region: FecR; pfam04773 509190001738 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509190001739 RNA polymerase sigma factor; Reviewed; Region: PRK12527 509190001740 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509190001741 DNA binding residues [nucleotide binding] 509190001742 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 509190001743 active site 509190001744 catalytic residues [active] 509190001745 lytic murein transglycosylase; Region: MltB_2; TIGR02283 509190001746 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 509190001747 N-acetyl-D-glucosamine binding site [chemical binding]; other site 509190001748 catalytic residue [active] 509190001749 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 509190001750 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 509190001751 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 509190001752 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 509190001753 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 509190001754 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 509190001755 hypothetical protein; Provisional; Region: PRK13694 509190001756 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 509190001757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190001758 active site 509190001759 phosphorylation site [posttranslational modification] 509190001760 intermolecular recognition site; other site 509190001761 dimerization interface [polypeptide binding]; other site 509190001762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509190001763 Walker A motif; other site 509190001764 ATP binding site [chemical binding]; other site 509190001765 Walker B motif; other site 509190001766 arginine finger; other site 509190001767 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 509190001768 Protein of unknown function (DUF419); Region: DUF419; cl15265 509190001769 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 509190001770 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 509190001771 active site 509190001772 Zn binding site [ion binding]; other site 509190001773 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 509190001774 ABC1 family; Region: ABC1; cl17513 509190001775 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 509190001776 active site 509190001777 ATP binding site [chemical binding]; other site 509190001778 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 509190001779 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509190001780 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509190001781 DNA binding residues [nucleotide binding] 509190001782 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 509190001783 CoenzymeA binding site [chemical binding]; other site 509190001784 subunit interaction site [polypeptide binding]; other site 509190001785 PHB binding site; other site 509190001786 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509190001787 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 509190001788 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 509190001789 putative active site [active] 509190001790 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 509190001791 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 509190001792 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 509190001793 ligand binding site [chemical binding]; other site 509190001794 homodimer interface [polypeptide binding]; other site 509190001795 NAD(P) binding site [chemical binding]; other site 509190001796 trimer interface B [polypeptide binding]; other site 509190001797 trimer interface A [polypeptide binding]; other site 509190001798 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 509190001799 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 509190001800 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 509190001801 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 509190001802 Peptidase family M23; Region: Peptidase_M23; pfam01551 509190001803 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509190001804 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 509190001805 catalytic site [active] 509190001806 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 509190001807 Uncharacterized conserved protein [Function unknown]; Region: COG5590 509190001808 COQ9; Region: COQ9; pfam08511 509190001809 Protein of unknown function (DUF1465); Region: DUF1465; cl11562 509190001810 Protein of unknown function (DUF1192); Region: DUF1192; cl11573 509190001811 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 509190001812 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 509190001813 NAD(P) binding site [chemical binding]; other site 509190001814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 509190001815 Uncharacterized small protein [Function unknown]; Region: COG5570 509190001816 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 509190001817 Flavoprotein; Region: Flavoprotein; pfam02441 509190001818 Protein of unknown function (DUF2390); Region: DUF2390; cl02376 509190001819 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 509190001820 Response regulator receiver domain; Region: Response_reg; pfam00072 509190001821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190001822 active site 509190001823 phosphorylation site [posttranslational modification] 509190001824 intermolecular recognition site; other site 509190001825 dimerization interface [polypeptide binding]; other site 509190001826 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 509190001827 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 509190001828 metal binding site [ion binding]; metal-binding site 509190001829 active site 509190001830 I-site; other site 509190001831 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 509190001832 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 509190001833 ATP-grasp domain; Region: ATP-grasp; pfam02222 509190001834 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 509190001835 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 509190001836 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 509190001837 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 509190001838 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509190001839 non-specific DNA binding site [nucleotide binding]; other site 509190001840 salt bridge; other site 509190001841 sequence-specific DNA binding site [nucleotide binding]; other site 509190001842 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 509190001843 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 509190001844 Walker A/P-loop; other site 509190001845 ATP binding site [chemical binding]; other site 509190001846 Q-loop/lid; other site 509190001847 ABC transporter signature motif; other site 509190001848 Walker B; other site 509190001849 D-loop; other site 509190001850 H-loop/switch region; other site 509190001851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 509190001852 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 509190001853 aspartate racemase; Region: asp_race; TIGR00035 509190001854 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 509190001855 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 509190001856 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 509190001857 Transglycosylase; Region: Transgly; pfam00912 509190001858 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 509190001859 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 509190001860 hypothetical protein; Provisional; Region: PRK05170 509190001861 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 509190001862 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 509190001863 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 509190001864 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509190001865 Walker A/P-loop; other site 509190001866 ATP binding site [chemical binding]; other site 509190001867 Q-loop/lid; other site 509190001868 ABC transporter signature motif; other site 509190001869 Walker B; other site 509190001870 D-loop; other site 509190001871 H-loop/switch region; other site 509190001872 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 509190001873 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 509190001874 putative active site [active] 509190001875 catalytic site [active] 509190001876 putative metal binding site [ion binding]; other site 509190001877 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 509190001878 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 509190001879 active site 509190001880 dimerization interface [polypeptide binding]; other site 509190001881 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 509190001882 thiamine phosphate binding site [chemical binding]; other site 509190001883 active site 509190001884 pyrophosphate binding site [ion binding]; other site 509190001885 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 509190001886 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 509190001887 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 509190001888 heme binding site [chemical binding]; other site 509190001889 ferroxidase pore; other site 509190001890 ferroxidase diiron center [ion binding]; other site 509190001891 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 509190001892 HAMP domain; Region: HAMP; pfam00672 509190001893 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 509190001894 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190001895 dimer interface [polypeptide binding]; other site 509190001896 putative CheW interface [polypeptide binding]; other site 509190001897 Predicted membrane protein [Function unknown]; Region: COG2259 509190001898 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 509190001899 hypothetical protein; Provisional; Region: PRK05409 509190001900 Predicted integral membrane protein [Function unknown]; Region: COG5572 509190001901 RNA polymerase sigma factor; Provisional; Region: PRK12536 509190001902 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509190001903 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509190001904 DNA binding residues [nucleotide binding] 509190001905 Protein of unknown function (DUF1109); Region: DUF1109; cl02071 509190001906 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 509190001907 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 509190001908 intersubunit interface [polypeptide binding]; other site 509190001909 active site 509190001910 zinc binding site [ion binding]; other site 509190001911 Na+ binding site [ion binding]; other site 509190001912 Phosphoglycerate kinase; Region: PGK; pfam00162 509190001913 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 509190001914 substrate binding site [chemical binding]; other site 509190001915 hinge regions; other site 509190001916 ADP binding site [chemical binding]; other site 509190001917 catalytic site [active] 509190001918 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 509190001919 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 509190001920 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 509190001921 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 509190001922 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509190001923 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509190001924 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 509190001925 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 509190001926 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 509190001927 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 509190001928 putative active site [active] 509190001929 metal binding site [ion binding]; metal-binding site 509190001930 homodimer binding site [polypeptide binding]; other site 509190001931 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 509190001932 hypothetical protein; Validated; Region: PRK00110 509190001933 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 509190001934 MgtC family; Region: MgtC; pfam02308 509190001935 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 509190001936 active site 509190001937 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 509190001938 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 509190001939 active site 509190001940 putative DNA-binding cleft [nucleotide binding]; other site 509190001941 dimer interface [polypeptide binding]; other site 509190001942 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 509190001943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509190001944 Walker A motif; other site 509190001945 ATP binding site [chemical binding]; other site 509190001946 Walker B motif; other site 509190001947 arginine finger; other site 509190001948 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 509190001949 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 509190001950 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 509190001951 active site 509190001952 TolQ protein; Region: tolQ; TIGR02796 509190001953 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 509190001954 TolR protein; Region: tolR; TIGR02801 509190001955 Gram-negative bacterial tonB protein; Region: TonB; cl10048 509190001956 translocation protein TolB; Provisional; Region: tolB; PRK05137 509190001957 TolB amino-terminal domain; Region: TolB_N; pfam04052 509190001958 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 509190001959 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 509190001960 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 509190001961 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 509190001962 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 509190001963 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 509190001964 ligand binding site [chemical binding]; other site 509190001965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 509190001966 Tetratricopeptide repeat; Region: TPR_6; pfam13174 509190001967 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 509190001968 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 509190001969 FtsH Extracellular; Region: FtsH_ext; pfam06480 509190001970 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 509190001971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509190001972 Walker A motif; other site 509190001973 ATP binding site [chemical binding]; other site 509190001974 Walker B motif; other site 509190001975 arginine finger; other site 509190001976 Peptidase family M41; Region: Peptidase_M41; pfam01434 509190001977 PAS fold; Region: PAS; pfam00989 509190001978 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190001979 putative active site [active] 509190001980 heme pocket [chemical binding]; other site 509190001981 PAS fold; Region: PAS_4; pfam08448 509190001982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190001983 ATP binding site [chemical binding]; other site 509190001984 Mg2+ binding site [ion binding]; other site 509190001985 G-X-G motif; other site 509190001986 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 509190001987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190001988 active site 509190001989 phosphorylation site [posttranslational modification] 509190001990 intermolecular recognition site; other site 509190001991 dimerization interface [polypeptide binding]; other site 509190001992 dihydropteroate synthase; Region: DHPS; TIGR01496 509190001993 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 509190001994 substrate binding pocket [chemical binding]; other site 509190001995 dimer interface [polypeptide binding]; other site 509190001996 inhibitor binding site; inhibition site 509190001997 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 509190001998 dimer interface [polypeptide binding]; other site 509190001999 substrate binding site [chemical binding]; other site 509190002000 ATP binding site [chemical binding]; other site 509190002001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 509190002002 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 509190002003 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190002004 dimer interface [polypeptide binding]; other site 509190002005 phosphorylation site [posttranslational modification] 509190002006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190002007 ATP binding site [chemical binding]; other site 509190002008 Mg2+ binding site [ion binding]; other site 509190002009 G-X-G motif; other site 509190002010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190002011 Response regulator receiver domain; Region: Response_reg; pfam00072 509190002012 active site 509190002013 phosphorylation site [posttranslational modification] 509190002014 intermolecular recognition site; other site 509190002015 dimerization interface [polypeptide binding]; other site 509190002016 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 509190002017 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509190002018 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 509190002019 catalytic residue [active] 509190002020 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 509190002021 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 509190002022 ligand binding site [chemical binding]; other site 509190002023 NAD binding site [chemical binding]; other site 509190002024 dimerization interface [polypeptide binding]; other site 509190002025 catalytic site [active] 509190002026 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 509190002027 putative L-serine binding site [chemical binding]; other site 509190002028 VanZ like family; Region: VanZ; pfam04892 509190002029 DNA Polymerase Y-family; Region: PolY_like; cd03468 509190002030 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 509190002031 DNA binding site [nucleotide binding] 509190002032 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 509190002033 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 509190002034 putative active site [active] 509190002035 putative PHP Thumb interface [polypeptide binding]; other site 509190002036 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 509190002037 generic binding surface I; other site 509190002038 generic binding surface II; other site 509190002039 putative acyl-CoA synthetase; Provisional; Region: PRK06018 509190002040 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 509190002041 dimer interface [polypeptide binding]; other site 509190002042 acyl-activating enzyme (AAE) consensus motif; other site 509190002043 putative active site [active] 509190002044 AMP binding site [chemical binding]; other site 509190002045 putative CoA binding site [chemical binding]; other site 509190002046 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190002047 dimer interface [polypeptide binding]; other site 509190002048 phosphorylation site [posttranslational modification] 509190002049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190002050 ATP binding site [chemical binding]; other site 509190002051 Mg2+ binding site [ion binding]; other site 509190002052 G-X-G motif; other site 509190002053 Response regulator receiver domain; Region: Response_reg; pfam00072 509190002054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190002055 active site 509190002056 phosphorylation site [posttranslational modification] 509190002057 intermolecular recognition site; other site 509190002058 dimerization interface [polypeptide binding]; other site 509190002059 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 509190002060 Beta-lactamase; Region: Beta-lactamase; pfam00144 509190002061 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 509190002062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 509190002063 Predicted kinase [General function prediction only]; Region: COG0645 509190002064 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 509190002065 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190002066 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190002067 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 509190002068 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 509190002069 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509190002070 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190002071 The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453 509190002072 putative dimerization interface [polypeptide binding]; other site 509190002073 putative substrate binding pocket [chemical binding]; other site 509190002074 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 509190002075 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 509190002076 NAD(P) binding site [chemical binding]; other site 509190002077 homodimer interface [polypeptide binding]; other site 509190002078 substrate binding site [chemical binding]; other site 509190002079 active site 509190002080 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 509190002081 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 509190002082 dimer interface [polypeptide binding]; other site 509190002083 putative functional site; other site 509190002084 putative MPT binding site; other site 509190002085 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 509190002086 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 509190002087 FAD binding pocket [chemical binding]; other site 509190002088 FAD binding motif [chemical binding]; other site 509190002089 phosphate binding motif [ion binding]; other site 509190002090 beta-alpha-beta structure motif; other site 509190002091 NAD binding pocket [chemical binding]; other site 509190002092 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 509190002093 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 509190002094 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 509190002095 putative homodimer interface [polypeptide binding]; other site 509190002096 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 509190002097 heterodimer interface [polypeptide binding]; other site 509190002098 homodimer interface [polypeptide binding]; other site 509190002099 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 509190002100 Beta-lactamase; Region: Beta-lactamase; pfam00144 509190002101 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 509190002102 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 509190002103 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 509190002104 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 509190002105 23S rRNA interface [nucleotide binding]; other site 509190002106 L7/L12 interface [polypeptide binding]; other site 509190002107 putative thiostrepton binding site; other site 509190002108 L25 interface [polypeptide binding]; other site 509190002109 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 509190002110 mRNA/rRNA interface [nucleotide binding]; other site 509190002111 Predicted flavoproteins [General function prediction only]; Region: COG2081 509190002112 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 509190002113 HIT family signature motif; other site 509190002114 catalytic residue [active] 509190002115 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 509190002116 23S rRNA interface [nucleotide binding]; other site 509190002117 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 509190002118 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 509190002119 L11 interface [polypeptide binding]; other site 509190002120 putative EF-Tu interaction site [polypeptide binding]; other site 509190002121 putative EF-G interaction site [polypeptide binding]; other site 509190002122 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 509190002123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190002124 PAS domain; Region: PAS_9; pfam13426 509190002125 putative active site [active] 509190002126 heme pocket [chemical binding]; other site 509190002127 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 509190002128 Histidine kinase; Region: HisKA_2; pfam07568 509190002129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190002130 ATP binding site [chemical binding]; other site 509190002131 Mg2+ binding site [ion binding]; other site 509190002132 G-X-G motif; other site 509190002133 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 509190002134 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 509190002135 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 509190002136 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 509190002137 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 509190002138 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 509190002139 RPB12 interaction site [polypeptide binding]; other site 509190002140 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 509190002141 RPB1 interaction site [polypeptide binding]; other site 509190002142 RPB11 interaction site [polypeptide binding]; other site 509190002143 RPB10 interaction site [polypeptide binding]; other site 509190002144 RPB3 interaction site [polypeptide binding]; other site 509190002145 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 509190002146 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 509190002147 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 509190002148 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 509190002149 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 509190002150 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 509190002151 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 509190002152 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 509190002153 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 509190002154 DNA binding site [nucleotide binding] 509190002155 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 509190002156 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 509190002157 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 509190002158 dimerization interface [polypeptide binding]; other site 509190002159 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190002160 dimer interface [polypeptide binding]; other site 509190002161 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 509190002162 putative CheW interface [polypeptide binding]; other site 509190002163 Predicted integral membrane protein [Function unknown]; Region: COG5528 509190002164 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509190002165 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190002166 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509190002167 dimerization interface [polypeptide binding]; other site 509190002168 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 509190002169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190002170 NAD(P) binding site [chemical binding]; other site 509190002171 active site 509190002172 hypothetical protein; Provisional; Region: PRK06489 509190002173 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 509190002174 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 509190002175 S17 interaction site [polypeptide binding]; other site 509190002176 S8 interaction site; other site 509190002177 16S rRNA interaction site [nucleotide binding]; other site 509190002178 streptomycin interaction site [chemical binding]; other site 509190002179 23S rRNA interaction site [nucleotide binding]; other site 509190002180 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 509190002181 30S ribosomal protein S7; Validated; Region: PRK05302 509190002182 elongation factor G; Reviewed; Region: PRK00007 509190002183 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 509190002184 G1 box; other site 509190002185 putative GEF interaction site [polypeptide binding]; other site 509190002186 GTP/Mg2+ binding site [chemical binding]; other site 509190002187 Switch I region; other site 509190002188 G2 box; other site 509190002189 G3 box; other site 509190002190 Switch II region; other site 509190002191 G4 box; other site 509190002192 G5 box; other site 509190002193 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 509190002194 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 509190002195 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 509190002196 elongation factor Tu; Reviewed; Region: PRK00049 509190002197 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 509190002198 G1 box; other site 509190002199 GEF interaction site [polypeptide binding]; other site 509190002200 GTP/Mg2+ binding site [chemical binding]; other site 509190002201 Switch I region; other site 509190002202 G2 box; other site 509190002203 G3 box; other site 509190002204 Switch II region; other site 509190002205 G4 box; other site 509190002206 G5 box; other site 509190002207 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 509190002208 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 509190002209 Antibiotic Binding Site [chemical binding]; other site 509190002210 Putative esterase; Region: Esterase; pfam00756 509190002211 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 509190002212 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 509190002213 hydroperoxidase II; Provisional; Region: katE; PRK11249 509190002214 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 509190002215 tetramer interface [polypeptide binding]; other site 509190002216 heme binding pocket [chemical binding]; other site 509190002217 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 509190002218 domain interactions; other site 509190002219 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 509190002220 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 509190002221 Histidine kinase; Region: HisKA_2; pfam07568 509190002222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509190002223 Coenzyme A binding pocket [chemical binding]; other site 509190002224 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 509190002225 Protein export membrane protein; Region: SecD_SecF; cl14618 509190002226 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 509190002227 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 509190002228 HlyD family secretion protein; Region: HlyD_3; pfam13437 509190002229 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 509190002230 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 509190002231 heme-binding site [chemical binding]; other site 509190002232 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190002233 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190002234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190002235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190002236 PAS domain; Region: PAS_9; pfam13426 509190002237 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190002238 putative active site [active] 509190002239 heme pocket [chemical binding]; other site 509190002240 PAS fold; Region: PAS_3; pfam08447 509190002241 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190002242 dimer interface [polypeptide binding]; other site 509190002243 phosphorylation site [posttranslational modification] 509190002244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190002245 ATP binding site [chemical binding]; other site 509190002246 Mg2+ binding site [ion binding]; other site 509190002247 G-X-G motif; other site 509190002248 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 509190002249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190002250 active site 509190002251 phosphorylation site [posttranslational modification] 509190002252 intermolecular recognition site; other site 509190002253 dimerization interface [polypeptide binding]; other site 509190002254 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 509190002255 Beta-lactamase; Region: Beta-lactamase; pfam00144 509190002256 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509190002257 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 509190002258 substrate binding site [chemical binding]; other site 509190002259 oxyanion hole (OAH) forming residues; other site 509190002260 trimer interface [polypeptide binding]; other site 509190002261 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 509190002262 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 509190002263 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 509190002264 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 509190002265 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 509190002266 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 509190002267 acyl-activating enzyme (AAE) consensus motif; other site 509190002268 acyl-activating enzyme (AAE) consensus motif; other site 509190002269 putative AMP binding site [chemical binding]; other site 509190002270 putative active site [active] 509190002271 putative CoA binding site [chemical binding]; other site 509190002272 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 509190002273 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 509190002274 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509190002275 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 509190002276 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 509190002277 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 509190002278 oligomer interface [polypeptide binding]; other site 509190002279 metal binding site [ion binding]; metal-binding site 509190002280 metal binding site [ion binding]; metal-binding site 509190002281 putative Cl binding site [ion binding]; other site 509190002282 basic sphincter; other site 509190002283 hydrophobic gate; other site 509190002284 periplasmic entrance; other site 509190002285 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 509190002286 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 509190002287 active site 509190002288 purine riboside binding site [chemical binding]; other site 509190002289 transcriptional regulator; Provisional; Region: PRK10632 509190002290 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190002291 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 509190002292 putative effector binding pocket; other site 509190002293 putative dimerization interface [polypeptide binding]; other site 509190002294 short chain dehydrogenase; Provisional; Region: PRK12937 509190002295 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 509190002296 NADP binding site [chemical binding]; other site 509190002297 homodimer interface [polypeptide binding]; other site 509190002298 active site 509190002299 substrate binding site [chemical binding]; other site 509190002300 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 509190002301 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 509190002302 NADP binding site [chemical binding]; other site 509190002303 active site 509190002304 steroid binding site; other site 509190002305 Pirin-related protein [General function prediction only]; Region: COG1741 509190002306 Pirin; Region: Pirin; pfam02678 509190002307 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 509190002308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190002309 metabolite-proton symporter; Region: 2A0106; TIGR00883 509190002310 putative substrate translocation pore; other site 509190002311 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 509190002312 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509190002313 putative DNA binding site [nucleotide binding]; other site 509190002314 putative Zn2+ binding site [ion binding]; other site 509190002315 AsnC family; Region: AsnC_trans_reg; pfam01037 509190002316 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 509190002317 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 509190002318 dimer interface [polypeptide binding]; other site 509190002319 PYR/PP interface [polypeptide binding]; other site 509190002320 TPP binding site [chemical binding]; other site 509190002321 substrate binding site [chemical binding]; other site 509190002322 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 509190002323 TPP-binding site [chemical binding]; other site 509190002324 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 509190002325 Predicted membrane protein [Function unknown]; Region: COG2311 509190002326 Protein of unknown function (DUF418); Region: DUF418; pfam04235 509190002327 Predicted dehydrogenase [General function prediction only]; Region: COG0579 509190002328 hydroxyglutarate oxidase; Provisional; Region: PRK11728 509190002329 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 509190002330 putative ADP-binding pocket [chemical binding]; other site 509190002331 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 509190002332 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 509190002333 Protein of unknown function (DUF497); Region: DUF497; pfam04365 509190002334 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 509190002335 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 509190002336 putative active site [active] 509190002337 catalytic site [active] 509190002338 putative metal binding site [ion binding]; other site 509190002339 oligomer interface [polypeptide binding]; other site 509190002340 Glycosyl hydrolase family 47; Region: Glyco_hydro_47; pfam01532 509190002341 PAS fold; Region: PAS_4; pfam08448 509190002342 PAS domain S-box; Region: sensory_box; TIGR00229 509190002343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190002344 putative active site [active] 509190002345 heme pocket [chemical binding]; other site 509190002346 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 509190002347 HWE histidine kinase; Region: HWE_HK; pfam07536 509190002348 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 509190002349 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509190002350 dimerization interface [polypeptide binding]; other site 509190002351 putative DNA binding site [nucleotide binding]; other site 509190002352 putative Zn2+ binding site [ion binding]; other site 509190002353 AsnC family; Region: AsnC_trans_reg; pfam01037 509190002354 methionine gamma-lyase; Provisional; Region: PRK07503 509190002355 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 509190002356 homodimer interface [polypeptide binding]; other site 509190002357 substrate-cofactor binding pocket; other site 509190002358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190002359 catalytic residue [active] 509190002360 PilZ domain; Region: PilZ; pfam07238 509190002361 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 509190002362 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509190002363 non-specific DNA binding site [nucleotide binding]; other site 509190002364 salt bridge; other site 509190002365 sequence-specific DNA binding site [nucleotide binding]; other site 509190002366 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 509190002367 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509190002368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190002369 ATP binding site [chemical binding]; other site 509190002370 Mg2+ binding site [ion binding]; other site 509190002371 G-X-G motif; other site 509190002372 Response regulator receiver domain; Region: Response_reg; pfam00072 509190002373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190002374 active site 509190002375 phosphorylation site [posttranslational modification] 509190002376 intermolecular recognition site; other site 509190002377 dimerization interface [polypeptide binding]; other site 509190002378 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190002379 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190002380 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190002381 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190002382 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 509190002383 Ligand Binding Site [chemical binding]; other site 509190002384 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 509190002385 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 509190002386 queuosine biosynthesis protein QueD; Region: queuosine_QueD; TIGR03367 509190002387 active site 509190002388 Response regulator receiver domain; Region: Response_reg; pfam00072 509190002389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190002390 active site 509190002391 phosphorylation site [posttranslational modification] 509190002392 intermolecular recognition site; other site 509190002393 dimerization interface [polypeptide binding]; other site 509190002394 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 509190002395 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 509190002396 Tetramer interface [polypeptide binding]; other site 509190002397 active site 509190002398 FMN-binding site [chemical binding]; other site 509190002399 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 509190002400 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 509190002401 Penicillinase repressor; Region: Pencillinase_R; cl17580 509190002402 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 509190002403 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509190002404 putative Zn2+ binding site [ion binding]; other site 509190002405 putative DNA binding site [nucleotide binding]; other site 509190002406 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509190002407 Coenzyme A binding pocket [chemical binding]; other site 509190002408 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 509190002409 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 509190002410 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 509190002411 inhibitor-cofactor binding pocket; inhibition site 509190002412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190002413 catalytic residue [active] 509190002414 Transcriptional regulators [Transcription]; Region: GntR; COG1802 509190002415 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509190002416 FCD domain; Region: FCD; pfam07729 509190002417 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 509190002418 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 509190002419 NAD(P) binding site [chemical binding]; other site 509190002420 catalytic residues [active] 509190002421 succinic semialdehyde dehydrogenase; Region: PLN02278 509190002422 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 509190002423 tetramerization interface [polypeptide binding]; other site 509190002424 NAD(P) binding site [chemical binding]; other site 509190002425 catalytic residues [active] 509190002426 aminotransferase; Validated; Region: PRK07046 509190002427 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 509190002428 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509190002429 catalytic residue [active] 509190002430 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 509190002431 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 509190002432 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 509190002433 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 509190002434 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 509190002435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509190002436 putative PBP binding loops; other site 509190002437 dimer interface [polypeptide binding]; other site 509190002438 ABC-ATPase subunit interface; other site 509190002439 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 509190002440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509190002441 dimer interface [polypeptide binding]; other site 509190002442 conserved gate region; other site 509190002443 putative PBP binding loops; other site 509190002444 ABC-ATPase subunit interface; other site 509190002445 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 509190002446 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 509190002447 Walker A/P-loop; other site 509190002448 ATP binding site [chemical binding]; other site 509190002449 Q-loop/lid; other site 509190002450 ABC transporter signature motif; other site 509190002451 Walker B; other site 509190002452 D-loop; other site 509190002453 H-loop/switch region; other site 509190002454 TOBE domain; Region: TOBE_2; pfam08402 509190002455 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 509190002456 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 509190002457 catalytic triad [active] 509190002458 putative aminotransferase; Validated; Region: PRK07480 509190002459 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 509190002460 inhibitor-cofactor binding pocket; inhibition site 509190002461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190002462 catalytic residue [active] 509190002463 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 509190002464 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 509190002465 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 509190002466 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 509190002467 TPR repeat; Region: TPR_11; pfam13414 509190002468 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 509190002469 TPR motif; other site 509190002470 TPR repeat; Region: TPR_11; pfam13414 509190002471 binding surface 509190002472 TPR repeat; Region: TPR_11; pfam13414 509190002473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 509190002474 TPR motif; other site 509190002475 binding surface 509190002476 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 509190002477 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190002478 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190002479 N-terminal plug; other site 509190002480 ligand-binding site [chemical binding]; other site 509190002481 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 509190002482 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 509190002483 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 509190002484 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 509190002485 active site 509190002486 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190002487 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190002488 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190002489 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 509190002490 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 509190002491 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 509190002492 [2Fe-2S] cluster binding site [ion binding]; other site 509190002493 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 509190002494 alpha subunit interface [polypeptide binding]; other site 509190002495 active site 509190002496 substrate binding site [chemical binding]; other site 509190002497 Fe binding site [ion binding]; other site 509190002498 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 509190002499 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 509190002500 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 509190002501 Protein export membrane protein; Region: SecD_SecF; cl14618 509190002502 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 509190002503 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 509190002504 HlyD family secretion protein; Region: HlyD_3; pfam13437 509190002505 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190002506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190002507 WHG domain; Region: WHG; pfam13305 509190002508 SnoaL-like domain; Region: SnoaL_2; pfam12680 509190002509 short chain dehydrogenase; Provisional; Region: PRK06500 509190002510 classical (c) SDRs; Region: SDR_c; cd05233 509190002511 NAD(P) binding site [chemical binding]; other site 509190002512 active site 509190002513 LysR family transcriptional regulator; Provisional; Region: PRK14997 509190002514 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190002515 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509190002516 dimerization interface [polypeptide binding]; other site 509190002517 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 509190002518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509190002519 DNA-binding site [nucleotide binding]; DNA binding site 509190002520 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509190002521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190002522 homodimer interface [polypeptide binding]; other site 509190002523 catalytic residue [active] 509190002524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 509190002525 Uncharacterized conserved protein [Function unknown]; Region: COG2128 509190002526 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 509190002527 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 509190002528 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509190002529 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 509190002530 SnoaL-like domain; Region: SnoaL_2; pfam12680 509190002531 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 509190002532 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 509190002533 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 509190002534 active site 509190002535 Predicted transcriptional regulators [Transcription]; Region: COG1733 509190002536 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 509190002537 Predicted transcriptional regulators [Transcription]; Region: COG1733 509190002538 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 509190002539 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 509190002540 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 509190002541 active site 509190002542 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 509190002543 Protein of unknown function DUF72; Region: DUF72; pfam01904 509190002544 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 509190002545 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 509190002546 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 509190002547 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 509190002548 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 509190002549 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 509190002550 PA/protease or protease-like domain interface [polypeptide binding]; other site 509190002551 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 509190002552 metal binding site [ion binding]; metal-binding site 509190002553 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 509190002554 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 509190002555 active site 509190002556 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 509190002557 dimer interface [polypeptide binding]; other site 509190002558 substrate binding site [chemical binding]; other site 509190002559 catalytic residue [active] 509190002560 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 509190002561 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 509190002562 tetramer interface [polypeptide binding]; other site 509190002563 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190002564 catalytic residue [active] 509190002565 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 509190002566 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 509190002567 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 509190002568 GDP-binding site [chemical binding]; other site 509190002569 ACT binding site; other site 509190002570 IMP binding site; other site 509190002571 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190002572 dimer interface [polypeptide binding]; other site 509190002573 phosphorylation site [posttranslational modification] 509190002574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190002575 ATP binding site [chemical binding]; other site 509190002576 Mg2+ binding site [ion binding]; other site 509190002577 G-X-G motif; other site 509190002578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190002579 Response regulator receiver domain; Region: Response_reg; pfam00072 509190002580 active site 509190002581 phosphorylation site [posttranslational modification] 509190002582 intermolecular recognition site; other site 509190002583 dimerization interface [polypeptide binding]; other site 509190002584 Response regulator receiver domain; Region: Response_reg; pfam00072 509190002585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190002586 active site 509190002587 phosphorylation site [posttranslational modification] 509190002588 intermolecular recognition site; other site 509190002589 dimerization interface [polypeptide binding]; other site 509190002590 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190002591 N-terminal plug; other site 509190002592 ligand-binding site [chemical binding]; other site 509190002593 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509190002594 TAP-like protein; Region: Abhydrolase_4; pfam08386 509190002595 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 509190002596 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 509190002597 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509190002598 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509190002599 DNA binding residues [nucleotide binding] 509190002600 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 509190002601 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 509190002602 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 509190002603 metal binding site [ion binding]; metal-binding site 509190002604 active site 509190002605 I-site; other site 509190002606 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 509190002607 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 509190002608 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 509190002609 tetramer interface [polypeptide binding]; other site 509190002610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190002611 catalytic residue [active] 509190002612 Epoxide hydrolase N terminus; Region: EHN; pfam06441 509190002613 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 509190002614 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 509190002615 EamA-like transporter family; Region: EamA; pfam00892 509190002616 EamA-like transporter family; Region: EamA; pfam00892 509190002617 Protein of unknown function (DUF2855); Region: DUF2855; pfam11017 509190002618 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 509190002619 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 509190002620 SEC-C motif; Region: SEC-C; pfam02810 509190002621 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 509190002622 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 509190002623 heterotetramer interface [polypeptide binding]; other site 509190002624 active site pocket [active] 509190002625 cleavage site 509190002626 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 509190002627 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 509190002628 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 509190002629 Walker A/P-loop; other site 509190002630 ATP binding site [chemical binding]; other site 509190002631 Q-loop/lid; other site 509190002632 ABC transporter signature motif; other site 509190002633 Walker B; other site 509190002634 D-loop; other site 509190002635 H-loop/switch region; other site 509190002636 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190002637 PAS fold; Region: PAS_3; pfam08447 509190002638 putative active site [active] 509190002639 heme pocket [chemical binding]; other site 509190002640 PAS fold; Region: PAS_3; pfam08447 509190002641 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 509190002642 PAS fold; Region: PAS_3; pfam08447 509190002643 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 509190002644 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 509190002645 HWE histidine kinase; Region: HWE_HK; pfam07536 509190002646 DEAD-like helicases superfamily; Region: DEXDc; smart00487 509190002647 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 509190002648 ATP binding site [chemical binding]; other site 509190002649 Mg++ binding site [ion binding]; other site 509190002650 motif III; other site 509190002651 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509190002652 nucleotide binding region [chemical binding]; other site 509190002653 ATP-binding site [chemical binding]; other site 509190002654 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 509190002655 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 509190002656 active site 509190002657 8-oxo-dGMP binding site [chemical binding]; other site 509190002658 nudix motif; other site 509190002659 metal binding site [ion binding]; metal-binding site 509190002660 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 509190002661 Methyltransferase domain; Region: Methyltransf_11; pfam08241 509190002662 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 509190002663 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 509190002664 active site 509190002665 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 509190002666 GSH binding site [chemical binding]; other site 509190002667 catalytic residues [active] 509190002668 nitrilase; Region: PLN02798 509190002669 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 509190002670 putative active site [active] 509190002671 catalytic triad [active] 509190002672 dimer interface [polypeptide binding]; other site 509190002673 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 509190002674 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 509190002675 DNA binding residues [nucleotide binding] 509190002676 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 509190002677 putative alpha-glucosidase; Provisional; Region: PRK10658 509190002678 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 509190002679 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 509190002680 putative active site [active] 509190002681 putative catalytic site [active] 509190002682 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 509190002683 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 509190002684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190002685 S-adenosylmethionine binding site [chemical binding]; other site 509190002686 aspartate kinase; Reviewed; Region: PRK06635 509190002687 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 509190002688 putative nucleotide binding site [chemical binding]; other site 509190002689 putative catalytic residues [active] 509190002690 putative Mg ion binding site [ion binding]; other site 509190002691 putative aspartate binding site [chemical binding]; other site 509190002692 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 509190002693 putative allosteric regulatory site; other site 509190002694 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 509190002695 putative allosteric regulatory residue; other site 509190002696 Cupin domain; Region: Cupin_2; pfam07883 509190002697 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 509190002698 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190002699 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 509190002700 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 509190002701 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 509190002702 GAF domain; Region: GAF; pfam01590 509190002703 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 509190002704 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 509190002705 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 509190002706 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509190002707 non-specific DNA binding site [nucleotide binding]; other site 509190002708 salt bridge; other site 509190002709 sequence-specific DNA binding site [nucleotide binding]; other site 509190002710 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 509190002711 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 509190002712 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 509190002713 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 509190002714 Active site serine [active] 509190002715 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 509190002716 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190002717 ACT domain; Region: ACT_6; pfam13740 509190002718 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 509190002719 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 509190002720 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 509190002721 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 509190002722 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 509190002723 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509190002724 RNA binding surface [nucleotide binding]; other site 509190002725 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 509190002726 active site 509190002727 peptide chain release factor 1; Validated; Region: prfA; PRK00591 509190002728 This domain is found in peptide chain release factors; Region: PCRF; smart00937 509190002729 RF-1 domain; Region: RF-1; pfam00472 509190002730 CHASE4 domain; Region: CHASE4; cl01308 509190002731 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 509190002732 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 509190002733 metal binding site [ion binding]; metal-binding site 509190002734 active site 509190002735 I-site; other site 509190002736 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 509190002737 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190002738 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190002739 N-terminal plug; other site 509190002740 ligand-binding site [chemical binding]; other site 509190002741 Uncharacterized conserved protein [Function unknown]; Region: COG5649 509190002742 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 509190002743 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 509190002744 dimerization interface [polypeptide binding]; other site 509190002745 DPS ferroxidase diiron center [ion binding]; other site 509190002746 ion pore; other site 509190002747 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 509190002748 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 509190002749 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 509190002750 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 509190002751 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509190002752 pseudaminic acid synthase; Region: PseI; TIGR03586 509190002753 NeuB family; Region: NeuB; pfam03102 509190002754 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 509190002755 NeuB binding interface [polypeptide binding]; other site 509190002756 putative substrate binding site [chemical binding]; other site 509190002757 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 509190002758 nudix motif; other site 509190002759 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 509190002760 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509190002761 putative Zn2+ binding site [ion binding]; other site 509190002762 putative DNA binding site [nucleotide binding]; other site 509190002763 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 509190002764 active site residue [active] 509190002765 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 509190002766 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 509190002767 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 509190002768 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 509190002769 ligand binding site; other site 509190002770 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509190002771 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 509190002772 putative C-terminal domain interface [polypeptide binding]; other site 509190002773 putative GSH binding site (G-site) [chemical binding]; other site 509190002774 putative dimer interface [polypeptide binding]; other site 509190002775 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 509190002776 putative N-terminal domain interface [polypeptide binding]; other site 509190002777 putative dimer interface [polypeptide binding]; other site 509190002778 putative substrate binding pocket (H-site) [chemical binding]; other site 509190002779 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 509190002780 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190002781 dimer interface [polypeptide binding]; other site 509190002782 putative CheW interface [polypeptide binding]; other site 509190002783 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 509190002784 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 509190002785 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 509190002786 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 509190002787 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 509190002788 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 509190002789 active site 509190002790 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 509190002791 HWE histidine kinase; Region: HWE_HK; pfam07536 509190002792 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 509190002793 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 509190002794 DNA-binding site [nucleotide binding]; DNA binding site 509190002795 RNA-binding motif; other site 509190002796 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 509190002797 nucleophile elbow; other site 509190002798 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 509190002799 LytTr DNA-binding domain; Region: LytTR; smart00850 509190002800 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 509190002801 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 509190002802 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 509190002803 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 509190002804 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 509190002805 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 509190002806 ATP-grasp domain; Region: ATP-grasp_4; cl17255 509190002807 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 509190002808 IMP binding site; other site 509190002809 dimer interface [polypeptide binding]; other site 509190002810 partial ornithine binding site; other site 509190002811 Predicted membrane protein [Function unknown]; Region: COG2246 509190002812 GtrA-like protein; Region: GtrA; pfam04138 509190002813 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 509190002814 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 509190002815 Ligand binding site; other site 509190002816 Putative Catalytic site; other site 509190002817 DXD motif; other site 509190002818 Hemerythrin-like domain; Region: Hr-like; cd12108 509190002819 Fe binding site [ion binding]; other site 509190002820 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 509190002821 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 509190002822 substrate binding pocket [chemical binding]; other site 509190002823 osmolarity response regulator; Provisional; Region: ompR; PRK09468 509190002824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190002825 active site 509190002826 phosphorylation site [posttranslational modification] 509190002827 intermolecular recognition site; other site 509190002828 dimerization interface [polypeptide binding]; other site 509190002829 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509190002830 DNA binding site [nucleotide binding] 509190002831 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 509190002832 dimerization interface [polypeptide binding]; other site 509190002833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190002834 ATP binding site [chemical binding]; other site 509190002835 Mg2+ binding site [ion binding]; other site 509190002836 G-X-G motif; other site 509190002837 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 509190002838 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 509190002839 GIY-YIG motif/motif A; other site 509190002840 active site 509190002841 catalytic site [active] 509190002842 putative DNA binding site [nucleotide binding]; other site 509190002843 metal binding site [ion binding]; metal-binding site 509190002844 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 509190002845 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 509190002846 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879 509190002847 Predicted membrane protein [Function unknown]; Region: COG3371 509190002848 Protein of unknown function (DUF998); Region: DUF998; pfam06197 509190002849 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 509190002850 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 509190002851 PA_M28_1_1: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 1. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_1; cd04820 509190002852 PA/protease or protease-like domain interface [polypeptide binding]; other site 509190002853 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661 509190002854 metal binding site [ion binding]; metal-binding site 509190002855 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 509190002856 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 509190002857 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 509190002858 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 509190002859 catalytic site [active] 509190002860 subunit interface [polypeptide binding]; other site 509190002861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 509190002862 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 509190002863 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 509190002864 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190002865 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190002866 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 509190002867 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509190002868 motif II; other site 509190002869 Acyltransferase family; Region: Acyl_transf_3; pfam01757 509190002870 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 509190002871 putative active site [active] 509190002872 Transcriptional regulators [Transcription]; Region: FadR; COG2186 509190002873 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509190002874 DNA-binding site [nucleotide binding]; DNA binding site 509190002875 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 509190002876 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 509190002877 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 509190002878 metal binding site [ion binding]; metal-binding site 509190002879 substrate binding pocket [chemical binding]; other site 509190002880 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 509190002881 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 509190002882 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 509190002883 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 509190002884 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 509190002885 metal binding site [ion binding]; metal-binding site 509190002886 putative dimer interface [polypeptide binding]; other site 509190002887 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 509190002888 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 509190002889 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 509190002890 inhibitor binding site; inhibition site 509190002891 active site 509190002892 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 509190002893 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 509190002894 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 509190002895 CHASE4 domain; Region: CHASE4; pfam05228 509190002896 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509190002897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190002898 dimer interface [polypeptide binding]; other site 509190002899 phosphorylation site [posttranslational modification] 509190002900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190002901 ATP binding site [chemical binding]; other site 509190002902 Mg2+ binding site [ion binding]; other site 509190002903 G-X-G motif; other site 509190002904 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 509190002905 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 509190002906 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 509190002907 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 509190002908 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 509190002909 dimer interface [polypeptide binding]; other site 509190002910 NADP binding site [chemical binding]; other site 509190002911 catalytic residues [active] 509190002912 Uncharacterized conserved protein [Function unknown]; Region: COG5323 509190002913 Terminase-like family; Region: Terminase_6; pfam03237 509190002914 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 509190002915 putative active site [active] 509190002916 Phage-related protein [Function unknown]; Region: COG4695 509190002917 Phage portal protein; Region: Phage_portal; pfam04860 509190002918 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 509190002919 BLMT, a bleomycin resistance protein encoded on the transposon Tn5, and similar proteins; Region: BLMT_like; cd08350 509190002920 dimer interface [polypeptide binding]; other site 509190002921 ligand binding site [chemical binding]; other site 509190002922 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 509190002923 Phage capsid family; Region: Phage_capsid; pfam05065 509190002924 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 509190002925 oligomerization interface [polypeptide binding]; other site 509190002926 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 509190002927 Phage major tail protein 2; Region: Phage_tail_2; cl11463 509190002928 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 509190002929 Conserved hypothetical phage protein (DUF2376); Region: DUF2376; pfam09550 509190002930 Predicted membrane protein [Function unknown]; Region: COG3152 509190002931 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 509190002932 Uncharacterized conserved protein [Function unknown]; Region: COG5449 509190002933 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 509190002934 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 509190002935 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 509190002936 putative phage cell wall peptidase, NlpC/P60 family; Region: phage_NlpC_fam; TIGR02219 509190002937 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 509190002938 Putative phage tail protein; Region: Phage-tail_3; pfam13550 509190002939 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 509190002940 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 509190002941 HSP70 interaction site [polypeptide binding]; other site 509190002942 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 509190002943 substrate binding site [polypeptide binding]; other site 509190002944 dimer interface [polypeptide binding]; other site 509190002945 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190002946 Predicted membrane protein [Function unknown]; Region: COG3212 509190002947 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 509190002948 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 509190002949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190002950 active site 509190002951 phosphorylation site [posttranslational modification] 509190002952 intermolecular recognition site; other site 509190002953 dimerization interface [polypeptide binding]; other site 509190002954 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509190002955 DNA binding site [nucleotide binding] 509190002956 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 509190002957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190002958 ATP binding site [chemical binding]; other site 509190002959 Mg2+ binding site [ion binding]; other site 509190002960 G-X-G motif; other site 509190002961 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 509190002962 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 509190002963 TPR motif; other site 509190002964 binding surface 509190002965 Cytochrome c-type biogenesis protein CcmE [Posttranslational modification, protein turnover, chaperones]; Region: CcmE; COG2332 509190002966 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 509190002967 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 509190002968 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 509190002969 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 509190002970 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 509190002971 protein binding site [polypeptide binding]; other site 509190002972 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 509190002973 protein binding site [polypeptide binding]; other site 509190002974 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 509190002975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190002976 active site 509190002977 phosphorylation site [posttranslational modification] 509190002978 intermolecular recognition site; other site 509190002979 dimerization interface [polypeptide binding]; other site 509190002980 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509190002981 DNA binding site [nucleotide binding] 509190002982 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509190002983 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 509190002984 dimerization interface [polypeptide binding]; other site 509190002985 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 509190002986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190002987 ATP binding site [chemical binding]; other site 509190002988 Mg2+ binding site [ion binding]; other site 509190002989 G-X-G motif; other site 509190002990 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 509190002991 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 509190002992 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 509190002993 Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391 509190002994 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 509190002995 metal binding triad; other site 509190002996 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 509190002997 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 509190002998 metal binding triad; other site 509190002999 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 509190003000 Ca2+ binding site [ion binding]; other site 509190003001 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 509190003002 Ca2+ binding site [ion binding]; other site 509190003003 RNA polymerase sigma factor; Reviewed; Region: PRK05602 509190003004 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509190003005 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509190003006 DNA binding residues [nucleotide binding] 509190003007 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 509190003008 TMAO/DMSO reductase; Reviewed; Region: PRK05363 509190003009 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 509190003010 Moco binding site; other site 509190003011 metal coordination site [ion binding]; other site 509190003012 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 509190003013 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 509190003014 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 509190003015 active site 509190003016 dimer interface [polypeptide binding]; other site 509190003017 hypothetical protein; Reviewed; Region: PRK00024 509190003018 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 509190003019 MPN+ (JAMM) motif; other site 509190003020 Zinc-binding site [ion binding]; other site 509190003021 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 509190003022 active site 509190003023 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 509190003024 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 509190003025 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 509190003026 putative MPT binding site; other site 509190003027 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 509190003028 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509190003029 non-specific DNA binding site [nucleotide binding]; other site 509190003030 salt bridge; other site 509190003031 sequence-specific DNA binding site [nucleotide binding]; other site 509190003032 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 509190003033 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 509190003034 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 509190003035 active site 509190003036 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 509190003037 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 509190003038 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509190003039 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 509190003040 GAF domain; Region: GAF; pfam01590 509190003041 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190003042 PAS domain; Region: PAS_9; pfam13426 509190003043 putative active site [active] 509190003044 heme pocket [chemical binding]; other site 509190003045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190003046 dimer interface [polypeptide binding]; other site 509190003047 phosphorylation site [posttranslational modification] 509190003048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190003049 ATP binding site [chemical binding]; other site 509190003050 Mg2+ binding site [ion binding]; other site 509190003051 G-X-G motif; other site 509190003052 Response regulator receiver domain; Region: Response_reg; pfam00072 509190003053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190003054 active site 509190003055 phosphorylation site [posttranslational modification] 509190003056 intermolecular recognition site; other site 509190003057 dimerization interface [polypeptide binding]; other site 509190003058 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 509190003059 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 509190003060 Walker A/P-loop; other site 509190003061 ATP binding site [chemical binding]; other site 509190003062 Q-loop/lid; other site 509190003063 ABC transporter signature motif; other site 509190003064 Walker B; other site 509190003065 D-loop; other site 509190003066 H-loop/switch region; other site 509190003067 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 509190003068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509190003069 dimer interface [polypeptide binding]; other site 509190003070 conserved gate region; other site 509190003071 ABC-ATPase subunit interface; other site 509190003072 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 509190003073 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 509190003074 Transcriptional regulators [Transcription]; Region: GntR; COG1802 509190003075 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509190003076 DNA-binding site [nucleotide binding]; DNA binding site 509190003077 FCD domain; Region: FCD; pfam07729 509190003078 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190003079 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 509190003080 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190003081 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 509190003082 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 509190003083 classical (c) SDRs; Region: SDR_c; cd05233 509190003084 NAD(P) binding site [chemical binding]; other site 509190003085 active site 509190003086 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 509190003087 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 509190003088 putative FMN binding site [chemical binding]; other site 509190003089 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 509190003090 ADP-ribose binding site [chemical binding]; other site 509190003091 dimer interface [polypeptide binding]; other site 509190003092 active site 509190003093 nudix motif; other site 509190003094 metal binding site [ion binding]; metal-binding site 509190003095 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 509190003096 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 509190003097 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 509190003098 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 509190003099 trimer interface [polypeptide binding]; other site 509190003100 active site 509190003101 substrate binding site [chemical binding]; other site 509190003102 CoA binding site [chemical binding]; other site 509190003103 Glutamine cyclotransferase; Region: Glu_cyclase_2; pfam05096 509190003104 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 509190003105 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190003106 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 509190003107 dimerization interface [polypeptide binding]; other site 509190003108 substrate binding pocket [chemical binding]; other site 509190003109 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 509190003110 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509190003111 Predicted acetyltransferase [General function prediction only]; Region: COG3393 509190003112 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509190003113 Coenzyme A binding pocket [chemical binding]; other site 509190003114 Predicted membrane protein [Function unknown]; Region: COG1297 509190003115 putative oligopeptide transporter, OPT family; Region: TIGR00733 509190003116 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 509190003117 PhoH-like protein; Region: PhoH; pfam02562 509190003118 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 509190003119 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 509190003120 trimer interface [polypeptide binding]; other site 509190003121 putative metal binding site [ion binding]; other site 509190003122 choline dehydrogenase; Validated; Region: PRK02106 509190003123 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 509190003124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 509190003125 PAS domain; Region: PAS_5; pfam07310 509190003126 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 509190003127 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 509190003128 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 509190003129 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 509190003130 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 509190003131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 509190003132 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 509190003133 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 509190003134 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 509190003135 Walker A/P-loop; other site 509190003136 ATP binding site [chemical binding]; other site 509190003137 Q-loop/lid; other site 509190003138 ABC transporter signature motif; other site 509190003139 Walker B; other site 509190003140 D-loop; other site 509190003141 H-loop/switch region; other site 509190003142 NMT1/THI5 like; Region: NMT1; pfam09084 509190003143 MASE1; Region: MASE1; pfam05231 509190003144 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190003145 dimer interface [polypeptide binding]; other site 509190003146 phosphorylation site [posttranslational modification] 509190003147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190003148 ATP binding site [chemical binding]; other site 509190003149 Mg2+ binding site [ion binding]; other site 509190003150 G-X-G motif; other site 509190003151 Response regulator receiver domain; Region: Response_reg; pfam00072 509190003152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190003153 active site 509190003154 phosphorylation site [posttranslational modification] 509190003155 intermolecular recognition site; other site 509190003156 dimerization interface [polypeptide binding]; other site 509190003157 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 509190003158 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 509190003159 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 509190003160 Rhomboid family; Region: Rhomboid; cl11446 509190003161 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 509190003162 FOG: CBS domain [General function prediction only]; Region: COG0517 509190003163 Predicted transcriptional regulator [Transcription]; Region: COG1959 509190003164 Transcriptional regulator; Region: Rrf2; pfam02082 509190003165 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 509190003166 DNA-binding site [nucleotide binding]; DNA binding site 509190003167 RNA-binding motif; other site 509190003168 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 509190003169 DNA-binding site [nucleotide binding]; DNA binding site 509190003170 RNA-binding motif; other site 509190003171 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 509190003172 Malic enzyme, N-terminal domain; Region: malic; pfam00390 509190003173 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 509190003174 putative NAD(P) binding site [chemical binding]; other site 509190003175 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 509190003176 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 509190003177 active site 509190003178 homotetramer interface [polypeptide binding]; other site 509190003179 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 509190003180 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111 509190003181 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 509190003182 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 509190003183 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 509190003184 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 509190003185 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 509190003186 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 509190003187 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 509190003188 XdhC Rossmann domain; Region: XdhC_C; pfam13478 509190003189 guanine deaminase; Provisional; Region: PRK09228 509190003190 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 509190003191 active site 509190003192 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 509190003193 active site 509190003194 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 509190003195 amidase; Provisional; Region: PRK09201 509190003196 Amidase; Region: Amidase; pfam01425 509190003197 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 509190003198 Uncharacterized conserved protein [Function unknown]; Region: COG2353 509190003199 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190003200 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190003201 Predicted membrane protein [Function unknown]; Region: COG3748 509190003202 Protein of unknown function (DUF989); Region: DUF989; pfam06181 509190003203 Cytochrome c; Region: Cytochrom_C; pfam00034 509190003204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 509190003205 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 509190003206 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 509190003207 active site 509190003208 catalytic site [active] 509190003209 tetramer interface [polypeptide binding]; other site 509190003210 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 509190003211 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509190003212 catalytic residue [active] 509190003213 allantoate amidohydrolase; Reviewed; Region: PRK09290 509190003214 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 509190003215 active site 509190003216 metal binding site [ion binding]; metal-binding site 509190003217 dimer interface [polypeptide binding]; other site 509190003218 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 509190003219 Mechanosensitive ion channel; Region: MS_channel; pfam00924 509190003220 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 509190003221 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 509190003222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190003223 S-adenosylmethionine binding site [chemical binding]; other site 509190003224 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 509190003225 Glucose inhibited division protein A; Region: GIDA; pfam01134 509190003226 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509190003227 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 509190003228 putative C-terminal domain interface [polypeptide binding]; other site 509190003229 putative GSH binding site (G-site) [chemical binding]; other site 509190003230 putative dimer interface [polypeptide binding]; other site 509190003231 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 509190003232 N-terminal domain interface [polypeptide binding]; other site 509190003233 dimer interface [polypeptide binding]; other site 509190003234 substrate binding pocket (H-site) [chemical binding]; other site 509190003235 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 509190003236 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 509190003237 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 509190003238 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 509190003239 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 509190003240 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 509190003241 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 509190003242 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 509190003243 Protein of unknown function (DUF3422); Region: DUF3422; cl02073 509190003244 Predicted methyltransferase [General function prediction only]; Region: COG3897 509190003245 MAEBL; Provisional; Region: PTZ00121 509190003246 Rod binding protein; Region: Rod-binding; cl01626 509190003247 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 509190003248 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 509190003249 flagellar assembly regulator FliX; Reviewed; Region: fliX; PRK12787 509190003250 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 509190003251 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 509190003252 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509190003253 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 509190003254 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 509190003255 Response regulator receiver domain; Region: Response_reg; pfam00072 509190003256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190003257 active site 509190003258 phosphorylation site [posttranslational modification] 509190003259 intermolecular recognition site; other site 509190003260 dimerization interface [polypeptide binding]; other site 509190003261 enoyl-CoA hydratase; Provisional; Region: PRK09245 509190003262 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509190003263 substrate binding site [chemical binding]; other site 509190003264 oxyanion hole (OAH) forming residues; other site 509190003265 trimer interface [polypeptide binding]; other site 509190003266 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 509190003267 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 509190003268 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 509190003269 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 509190003270 EamA-like transporter family; Region: EamA; pfam00892 509190003271 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 509190003272 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 509190003273 amidase catalytic site [active] 509190003274 Zn binding residues [ion binding]; other site 509190003275 substrate binding site [chemical binding]; other site 509190003276 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 509190003277 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 509190003278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 509190003279 MraZ protein; Region: MraZ; pfam02381 509190003280 MraZ protein; Region: MraZ; pfam02381 509190003281 MraW methylase family; Region: Methyltransf_5; cl17771 509190003282 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 509190003283 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 509190003284 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 509190003285 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509190003286 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 509190003287 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 509190003288 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 509190003289 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509190003290 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 509190003291 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 509190003292 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 509190003293 Mg++ binding site [ion binding]; other site 509190003294 putative catalytic motif [active] 509190003295 putative substrate binding site [chemical binding]; other site 509190003296 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 509190003297 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 509190003298 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509190003299 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 509190003300 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 509190003301 Cl- selectivity filter; other site 509190003302 Cl- binding residues [ion binding]; other site 509190003303 pore gating glutamate residue; other site 509190003304 dimer interface [polypeptide binding]; other site 509190003305 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 509190003306 PAS fold; Region: PAS_4; pfam08448 509190003307 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190003308 putative active site [active] 509190003309 heme pocket [chemical binding]; other site 509190003310 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 509190003311 HWE histidine kinase; Region: HWE_HK; pfam07536 509190003312 cell division protein FtsW; Region: ftsW; TIGR02614 509190003313 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 509190003314 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 509190003315 active site 509190003316 homodimer interface [polypeptide binding]; other site 509190003317 Gram-negative bacterial tonB protein; Region: TonB; cl10048 509190003318 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 509190003319 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 509190003320 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509190003321 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 509190003322 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 509190003323 FAD binding domain; Region: FAD_binding_4; pfam01565 509190003324 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 509190003325 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 509190003326 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 509190003327 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 509190003328 PA/protease or protease-like domain interface [polypeptide binding]; other site 509190003329 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 509190003330 metal binding site [ion binding]; metal-binding site 509190003331 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 509190003332 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 509190003333 ATP-grasp domain; Region: ATP-grasp_4; cl17255 509190003334 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 509190003335 Cell division protein FtsQ; Region: FtsQ; pfam03799 509190003336 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 509190003337 Cell division protein FtsA; Region: FtsA; smart00842 509190003338 Cell division protein FtsA; Region: FtsA; pfam14450 509190003339 cell division protein FtsZ; Validated; Region: PRK09330 509190003340 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 509190003341 nucleotide binding site [chemical binding]; other site 509190003342 SulA interaction site; other site 509190003343 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 509190003344 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 509190003345 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 509190003346 CAAX protease self-immunity; Region: Abi; pfam02517 509190003347 SPFH domain / Band 7 family; Region: Band_7; pfam01145 509190003348 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 509190003349 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509190003350 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190003351 homodimer interface [polypeptide binding]; other site 509190003352 catalytic residue [active] 509190003353 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 509190003354 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 509190003355 dimer interface [polypeptide binding]; other site 509190003356 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 509190003357 active site 509190003358 Fe binding site [ion binding]; other site 509190003359 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 509190003360 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 509190003361 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 509190003362 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 509190003363 iron-sulfur cluster [ion binding]; other site 509190003364 [2Fe-2S] cluster binding site [ion binding]; other site 509190003365 Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632 509190003366 putative inhibitory loop; other site 509190003367 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 509190003368 homotrimer interaction site [polypeptide binding]; other site 509190003369 putative active site [active] 509190003370 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 509190003371 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 509190003372 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 509190003373 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 509190003374 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 509190003375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509190003376 Coenzyme A binding pocket [chemical binding]; other site 509190003377 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190003378 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190003379 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190003380 Predicted transcriptional regulator [Transcription]; Region: COG2378 509190003381 WYL domain; Region: WYL; pfam13280 509190003382 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 509190003383 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 509190003384 Chromate transporter; Region: Chromate_transp; cl17781 509190003385 Uncharacterized conserved protein [Function unknown]; Region: COG3743 509190003386 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 509190003387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 509190003388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 509190003389 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190003390 putative active site [active] 509190003391 PAS fold; Region: PAS_3; pfam08447 509190003392 heme pocket [chemical binding]; other site 509190003393 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 509190003394 recombinase A; Provisional; Region: recA; PRK09354 509190003395 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 509190003396 hexamer interface [polypeptide binding]; other site 509190003397 Walker A motif; other site 509190003398 ATP binding site [chemical binding]; other site 509190003399 Walker B motif; other site 509190003400 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 509190003401 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 509190003402 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 509190003403 motif 1; other site 509190003404 active site 509190003405 motif 2; other site 509190003406 motif 3; other site 509190003407 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 509190003408 DHHA1 domain; Region: DHHA1; pfam02272 509190003409 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 509190003410 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 509190003411 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 509190003412 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 509190003413 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 509190003414 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190003415 N-terminal plug; other site 509190003416 ligand-binding site [chemical binding]; other site 509190003417 Membrane transport protein; Region: Mem_trans; cl09117 509190003418 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 509190003419 isocitrate dehydrogenase; Validated; Region: PRK08299 509190003420 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509190003421 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190003422 dimer interface [polypeptide binding]; other site 509190003423 phosphorylation site [posttranslational modification] 509190003424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190003425 ATP binding site [chemical binding]; other site 509190003426 Mg2+ binding site [ion binding]; other site 509190003427 G-X-G motif; other site 509190003428 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 509190003429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190003430 active site 509190003431 phosphorylation site [posttranslational modification] 509190003432 intermolecular recognition site; other site 509190003433 dimerization interface [polypeptide binding]; other site 509190003434 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 509190003435 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 509190003436 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 509190003437 Protein required for attachment to host cells; Region: Host_attach; pfam10116 509190003438 Uncharacterized conserved protein [Function unknown]; Region: COG5361 509190003439 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 509190003440 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 509190003441 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 509190003442 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 509190003443 NAD(P) binding site [chemical binding]; other site 509190003444 S-formylglutathione hydrolase; Region: PLN02442 509190003445 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 509190003446 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 509190003447 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 509190003448 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509190003449 RNA binding surface [nucleotide binding]; other site 509190003450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3809 509190003451 heat shock protein HtpX; Provisional; Region: PRK01345 509190003452 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 509190003453 Beta-lactamase; Region: Beta-lactamase; pfam00144 509190003454 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 509190003455 active site 509190003456 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 509190003457 putative GSH binding site [chemical binding]; other site 509190003458 catalytic residues [active] 509190003459 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 509190003460 active site 509190003461 catalytic tetrad [active] 509190003462 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 509190003463 M28 Zn-Peptidases; Region: M28_like_2; cd05662 509190003464 Peptidase family M28; Region: Peptidase_M28; pfam04389 509190003465 metal binding site [ion binding]; metal-binding site 509190003466 PAS domain; Region: PAS_9; pfam13426 509190003467 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190003468 putative active site [active] 509190003469 heme pocket [chemical binding]; other site 509190003470 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509190003471 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190003472 dimer interface [polypeptide binding]; other site 509190003473 phosphorylation site [posttranslational modification] 509190003474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190003475 ATP binding site [chemical binding]; other site 509190003476 Mg2+ binding site [ion binding]; other site 509190003477 G-X-G motif; other site 509190003478 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 509190003479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190003480 active site 509190003481 phosphorylation site [posttranslational modification] 509190003482 intermolecular recognition site; other site 509190003483 dimerization interface [polypeptide binding]; other site 509190003484 PAS fold; Region: PAS_4; pfam08448 509190003485 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 509190003486 HWE histidine kinase; Region: HWE_HK; smart00911 509190003487 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 509190003488 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 509190003489 dimerization interface [polypeptide binding]; other site 509190003490 ATP binding site [chemical binding]; other site 509190003491 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 509190003492 dimerization interface [polypeptide binding]; other site 509190003493 ATP binding site [chemical binding]; other site 509190003494 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 509190003495 putative active site [active] 509190003496 putative catalytic site [active] 509190003497 putative Mg binding site IVb [ion binding]; other site 509190003498 putative phosphate binding site [ion binding]; other site 509190003499 putative DNA binding site [nucleotide binding]; other site 509190003500 putative Mg binding site IVa [ion binding]; other site 509190003501 Predicted acyl esterases [General function prediction only]; Region: COG2936 509190003502 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 509190003503 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 509190003504 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 509190003505 putative active site [active] 509190003506 catalytic triad [active] 509190003507 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 509190003508 Rubredoxin [Energy production and conversion]; Region: COG1773 509190003509 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 509190003510 iron binding site [ion binding]; other site 509190003511 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 509190003512 Cytochrome P450; Region: p450; cl12078 509190003513 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190003514 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190003515 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 509190003516 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 509190003517 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 509190003518 ATP binding site [chemical binding]; other site 509190003519 active site 509190003520 substrate binding site [chemical binding]; other site 509190003521 Uncharacterized conserved protein [Function unknown]; Region: COG5467 509190003522 Domain of unknown function (DUF1842); Region: DUF1842; pfam08896 509190003523 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 509190003524 putative active site [active] 509190003525 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 509190003526 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 509190003527 adenylosuccinate lyase; Provisional; Region: PRK07492 509190003528 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 509190003529 tetramer interface [polypeptide binding]; other site 509190003530 active site 509190003531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190003532 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509190003533 putative substrate translocation pore; other site 509190003534 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 509190003535 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509190003536 putative C-terminal domain interface [polypeptide binding]; other site 509190003537 putative GSH binding site (G-site) [chemical binding]; other site 509190003538 putative dimer interface [polypeptide binding]; other site 509190003539 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 509190003540 putative N-terminal domain interface [polypeptide binding]; other site 509190003541 putative dimer interface [polypeptide binding]; other site 509190003542 putative substrate binding pocket (H-site) [chemical binding]; other site 509190003543 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 509190003544 DNA binding site [nucleotide binding] 509190003545 hypothetical protein; Provisional; Region: PRK07208 509190003546 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 509190003547 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 509190003548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190003549 putative substrate translocation pore; other site 509190003550 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 509190003551 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 509190003552 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 509190003553 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 509190003554 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 509190003555 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 509190003556 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 509190003557 binding surface 509190003558 TPR motif; other site 509190003559 Ribosome-binding factor A; Region: RBFA; cl00542 509190003560 Protein of unknown function (DUF563); Region: DUF563; pfam04577 509190003561 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509190003562 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509190003563 active site 509190003564 Methyltransferase domain; Region: Methyltransf_11; pfam08241 509190003565 S-adenosylmethionine binding site [chemical binding]; other site 509190003566 Uncharacterized conserved protein [Function unknown]; Region: COG2013 509190003567 Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605 509190003568 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 509190003569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190003570 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 509190003571 dimerization interface [polypeptide binding]; other site 509190003572 substrate binding pocket [chemical binding]; other site 509190003573 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 509190003574 active site 509190003575 SAM binding site [chemical binding]; other site 509190003576 homodimer interface [polypeptide binding]; other site 509190003577 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 509190003578 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 509190003579 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 509190003580 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 509190003581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 509190003582 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 509190003583 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 509190003584 Active Sites [active] 509190003585 Beta-lactamase; Region: Beta-lactamase; pfam00144 509190003586 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 509190003587 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 509190003588 binding surface 509190003589 TPR repeat; Region: TPR_11; pfam13414 509190003590 TPR motif; other site 509190003591 Transcriptional regulator PadR-like family; Region: PadR; cl17335 509190003592 Predicted transcriptional regulators [Transcription]; Region: COG1695 509190003593 3D domain; Region: 3D; cl01439 509190003594 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509190003595 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 509190003596 putative C-terminal domain interface [polypeptide binding]; other site 509190003597 putative GSH binding site (G-site) [chemical binding]; other site 509190003598 putative dimer interface [polypeptide binding]; other site 509190003599 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 509190003600 N-terminal domain interface [polypeptide binding]; other site 509190003601 dimer interface [polypeptide binding]; other site 509190003602 substrate binding pocket (H-site) [chemical binding]; other site 509190003603 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 509190003604 nudix motif; other site 509190003605 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 509190003606 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 509190003607 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190003608 dimer interface [polypeptide binding]; other site 509190003609 phosphorylation site [posttranslational modification] 509190003610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190003611 ATP binding site [chemical binding]; other site 509190003612 Mg2+ binding site [ion binding]; other site 509190003613 G-X-G motif; other site 509190003614 aminopeptidase N; Provisional; Region: pepN; PRK14015 509190003615 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 509190003616 active site 509190003617 Zn binding site [ion binding]; other site 509190003618 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509190003619 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 509190003620 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 509190003621 active site 509190003622 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509190003623 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509190003624 active site 509190003625 von Willebrand factor; Region: vWF_A; pfam12450 509190003626 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 509190003627 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 509190003628 metal ion-dependent adhesion site (MIDAS); other site 509190003629 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 509190003630 amidase; Provisional; Region: PRK08137 509190003631 Amidase; Region: Amidase; cl11426 509190003632 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 509190003633 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 509190003634 active site 2 [active] 509190003635 active site 1 [active] 509190003636 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 509190003637 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509190003638 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 509190003639 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509190003640 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 509190003641 NodB motif; other site 509190003642 putative active site [active] 509190003643 putative catalytic site [active] 509190003644 putative Zn binding site [ion binding]; other site 509190003645 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 509190003646 active site 509190003647 catalytic triad [active] 509190003648 oxyanion hole [active] 509190003649 EF hand; Region: EF_hand_3; pfam13202 509190003650 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 509190003651 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 509190003652 Catalytic site [active] 509190003653 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 509190003654 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190003655 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190003656 N-terminal plug; other site 509190003657 ligand-binding site [chemical binding]; other site 509190003658 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 509190003659 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 509190003660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509190003661 Walker A/P-loop; other site 509190003662 ATP binding site [chemical binding]; other site 509190003663 Q-loop/lid; other site 509190003664 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 509190003665 ABC transporter signature motif; other site 509190003666 Walker B; other site 509190003667 D-loop; other site 509190003668 ABC transporter; Region: ABC_tran_2; pfam12848 509190003669 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 509190003670 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 509190003671 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 509190003672 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 509190003673 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 509190003674 putative ligand binding site [chemical binding]; other site 509190003675 NAD binding site [chemical binding]; other site 509190003676 catalytic site [active] 509190003677 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 509190003678 active site 509190003679 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 509190003680 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 509190003681 FAD binding site [chemical binding]; other site 509190003682 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 509190003683 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 509190003684 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 509190003685 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 509190003686 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 509190003687 substrate binding pocket [chemical binding]; other site 509190003688 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 509190003689 B12 binding site [chemical binding]; other site 509190003690 cobalt ligand [ion binding]; other site 509190003691 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 509190003692 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 509190003693 beta-galactosidase; Region: BGL; TIGR03356 509190003694 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 509190003695 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 509190003696 putative metal binding site [ion binding]; other site 509190003697 DnaJ domain; Region: DnaJ; pfam00226 509190003698 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 509190003699 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 509190003700 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509190003701 active site 509190003702 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 509190003703 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 509190003704 putative active site [active] 509190003705 putative FMN binding site [chemical binding]; other site 509190003706 putative substrate binding site [chemical binding]; other site 509190003707 putative catalytic residue [active] 509190003708 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 509190003709 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 509190003710 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 509190003711 folate binding site [chemical binding]; other site 509190003712 NADP+ binding site [chemical binding]; other site 509190003713 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273 509190003714 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 509190003715 putative NAD(P) binding site [chemical binding]; other site 509190003716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 509190003717 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 509190003718 ketol-acid reductoisomerase; Provisional; Region: PRK05479 509190003719 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 509190003720 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 509190003721 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509190003722 dimerization interface [polypeptide binding]; other site 509190003723 putative DNA binding site [nucleotide binding]; other site 509190003724 putative Zn2+ binding site [ion binding]; other site 509190003725 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 509190003726 putative hydrophobic ligand binding site [chemical binding]; other site 509190003727 Uncharacterized conserved protein [Function unknown]; Region: COG2353 509190003728 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 509190003729 Methyltransferase domain; Region: Methyltransf_26; pfam13659 509190003730 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 509190003731 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 509190003732 substrate binding pocket [chemical binding]; other site 509190003733 chain length determination region; other site 509190003734 substrate-Mg2+ binding site; other site 509190003735 catalytic residues [active] 509190003736 aspartate-rich region 1; other site 509190003737 active site lid residues [active] 509190003738 aspartate-rich region 2; other site 509190003739 hypothetical protein; Provisional; Region: PRK11770 509190003740 Domain of unknown function (DUF307); Region: DUF307; pfam03733 509190003741 Domain of unknown function (DUF307); Region: DUF307; pfam03733 509190003742 fumarate hydratase; Reviewed; Region: fumC; PRK00485 509190003743 Class II fumarases; Region: Fumarase_classII; cd01362 509190003744 active site 509190003745 tetramer interface [polypeptide binding]; other site 509190003746 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 509190003747 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 509190003748 Beta-lactamase; Region: Beta-lactamase; pfam00144 509190003749 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 509190003750 Peptidase C13 family; Region: Peptidase_C13; cl02159 509190003751 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 509190003752 CoenzymeA binding site [chemical binding]; other site 509190003753 subunit interaction site [polypeptide binding]; other site 509190003754 PHB binding site; other site 509190003755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 509190003756 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 509190003757 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 509190003758 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 509190003759 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190003760 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 509190003761 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 509190003762 putative valine binding site [chemical binding]; other site 509190003763 dimer interface [polypeptide binding]; other site 509190003764 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 509190003765 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 509190003766 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 509190003767 PYR/PP interface [polypeptide binding]; other site 509190003768 dimer interface [polypeptide binding]; other site 509190003769 TPP binding site [chemical binding]; other site 509190003770 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 509190003771 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 509190003772 TPP-binding site [chemical binding]; other site 509190003773 dimer interface [polypeptide binding]; other site 509190003774 Beta-lactamase; Region: Beta-lactamase; pfam00144 509190003775 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 509190003776 Competence-damaged protein; Region: CinA; pfam02464 509190003777 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 509190003778 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 509190003779 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 509190003780 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 509190003781 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509190003782 motif II; other site 509190003783 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 509190003784 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509190003785 motif II; other site 509190003786 Domain of unknown function DUF59; Region: DUF59; pfam01883 509190003787 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 509190003788 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 509190003789 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 509190003790 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 509190003791 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 509190003792 NAD binding site [chemical binding]; other site 509190003793 homodimer interface [polypeptide binding]; other site 509190003794 active site 509190003795 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 509190003796 HlyD family secretion protein; Region: HlyD_3; pfam13437 509190003797 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 509190003798 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 509190003799 Walker A/P-loop; other site 509190003800 ATP binding site [chemical binding]; other site 509190003801 Q-loop/lid; other site 509190003802 ABC transporter signature motif; other site 509190003803 Walker B; other site 509190003804 D-loop; other site 509190003805 H-loop/switch region; other site 509190003806 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 509190003807 FtsX-like permease family; Region: FtsX; pfam02687 509190003808 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 509190003809 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 509190003810 Nucleoside recognition; Region: Gate; pfam07670 509190003811 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 509190003812 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 509190003813 putative active site [active] 509190003814 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509190003815 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 509190003816 putative C-terminal domain interface [polypeptide binding]; other site 509190003817 putative GSH binding site (G-site) [chemical binding]; other site 509190003818 putative dimer interface [polypeptide binding]; other site 509190003819 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 509190003820 N-terminal domain interface [polypeptide binding]; other site 509190003821 dimer interface [polypeptide binding]; other site 509190003822 substrate binding pocket (H-site) [chemical binding]; other site 509190003823 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 509190003824 CoenzymeA binding site [chemical binding]; other site 509190003825 subunit interaction site [polypeptide binding]; other site 509190003826 PHB binding site; other site 509190003827 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 509190003828 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 509190003829 putative uracil binding site [chemical binding]; other site 509190003830 putative active site [active] 509190003831 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 509190003832 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 509190003833 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 509190003834 nucleophilic elbow; other site 509190003835 catalytic triad; other site 509190003836 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 509190003837 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 509190003838 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 509190003839 NAD binding site [chemical binding]; other site 509190003840 Phe binding site; other site 509190003841 putative transporter; Provisional; Region: PRK10504 509190003842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190003843 putative substrate translocation pore; other site 509190003844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190003845 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 509190003846 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 509190003847 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 509190003848 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190003849 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190003850 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 509190003851 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 509190003852 active site 509190003853 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 509190003854 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509190003855 non-specific DNA binding site [nucleotide binding]; other site 509190003856 salt bridge; other site 509190003857 sequence-specific DNA binding site [nucleotide binding]; other site 509190003858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 509190003859 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 509190003860 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509190003861 Coenzyme A binding pocket [chemical binding]; other site 509190003862 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 509190003863 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 509190003864 putative NAD(P) binding site [chemical binding]; other site 509190003865 dimer interface [polypeptide binding]; other site 509190003866 Predicted transcriptional regulators [Transcription]; Region: COG1733 509190003867 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509190003868 dimerization interface [polypeptide binding]; other site 509190003869 putative DNA binding site [nucleotide binding]; other site 509190003870 putative Zn2+ binding site [ion binding]; other site 509190003871 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 509190003872 catalytic core [active] 509190003873 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 509190003874 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 509190003875 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 509190003876 substrate binding pocket [chemical binding]; other site 509190003877 chain length determination region; other site 509190003878 substrate-Mg2+ binding site; other site 509190003879 catalytic residues [active] 509190003880 aspartate-rich region 1; other site 509190003881 active site lid residues [active] 509190003882 aspartate-rich region 2; other site 509190003883 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 509190003884 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 509190003885 TPP-binding site; other site 509190003886 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 509190003887 PYR/PP interface [polypeptide binding]; other site 509190003888 dimer interface [polypeptide binding]; other site 509190003889 TPP binding site [chemical binding]; other site 509190003890 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 509190003891 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 509190003892 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 509190003893 flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170 509190003894 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 509190003895 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 509190003896 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 509190003897 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 509190003898 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 509190003899 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 509190003900 flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397 509190003901 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 509190003902 Uncharacterized conserved protein [Function unknown]; Region: COG3334 509190003903 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 509190003904 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 509190003905 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 509190003906 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 509190003907 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 509190003908 putative active site [active] 509190003909 phosphogluconate dehydratase; Validated; Region: PRK09054 509190003910 6-phosphogluconate dehydratase; Region: edd; TIGR01196 509190003911 Glucokinase [Carbohydrate transport and metabolism]; Region: Glk; COG0837 509190003912 glucokinase, proteobacterial type; Region: glk; TIGR00749 509190003913 Transcriptional regulators [Transcription]; Region: PurR; COG1609 509190003914 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 509190003915 DNA binding site [nucleotide binding] 509190003916 domain linker motif; other site 509190003917 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 509190003918 putative dimerization interface [polypeptide binding]; other site 509190003919 putative ligand binding site [chemical binding]; other site 509190003920 pyruvate kinase; Provisional; Region: PRK06247 509190003921 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 509190003922 domain interfaces; other site 509190003923 active site 509190003924 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 509190003925 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 509190003926 ligand binding site [chemical binding]; other site 509190003927 flexible hinge region; other site 509190003928 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 509190003929 non-specific DNA interactions [nucleotide binding]; other site 509190003930 DNA binding site [nucleotide binding] 509190003931 sequence specific DNA binding site [nucleotide binding]; other site 509190003932 putative cAMP binding site [chemical binding]; other site 509190003933 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509190003934 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 509190003935 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 509190003936 active site 509190003937 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 509190003938 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 509190003939 putative catalytic residue [active] 509190003940 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509190003941 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 509190003942 active site 509190003943 Uncharacterized conserved protein [Function unknown]; Region: COG2898 509190003944 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 509190003945 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 509190003946 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 509190003947 putative active site [active] 509190003948 putative metal binding site [ion binding]; other site 509190003949 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 509190003950 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509190003951 ATP binding site [chemical binding]; other site 509190003952 putative Mg++ binding site [ion binding]; other site 509190003953 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509190003954 nucleotide binding region [chemical binding]; other site 509190003955 ATP-binding site [chemical binding]; other site 509190003956 DEAD/H associated; Region: DEAD_assoc; pfam08494 509190003957 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 509190003958 Predicted transcriptional regulator [Transcription]; Region: COG2944 509190003959 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 509190003960 hydrophobic ligand binding site; other site 509190003961 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 509190003962 aspartate racemase; Region: asp_race; TIGR00035 509190003963 D-cysteine desulfhydrase; Validated; Region: PRK03910 509190003964 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 509190003965 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509190003966 catalytic residue [active] 509190003967 TPR repeat; Region: TPR_11; pfam13414 509190003968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 509190003969 binding surface 509190003970 TPR motif; other site 509190003971 TPR repeat; Region: TPR_11; pfam13414 509190003972 Predicted metalloprotease [General function prediction only]; Region: COG2321 509190003973 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 509190003974 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 509190003975 homotrimer interaction site [polypeptide binding]; other site 509190003976 putative active site [active] 509190003977 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509190003978 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 509190003979 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 509190003980 ThiC-associated domain; Region: ThiC-associated; pfam13667 509190003981 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 509190003982 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 509190003983 FMN binding site [chemical binding]; other site 509190003984 dimer interface [polypeptide binding]; other site 509190003985 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 509190003986 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 509190003987 active site triad [active] 509190003988 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 509190003989 GIY-YIG motif/motif A; other site 509190003990 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 509190003991 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 509190003992 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 509190003993 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 509190003994 short chain dehydrogenase; Provisional; Region: PRK06701 509190003995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190003996 NAD(P) binding site [chemical binding]; other site 509190003997 active site 509190003998 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 509190003999 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 509190004000 cation binding site [ion binding]; other site 509190004001 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion protein; Provisional; Region: PRK14495 509190004002 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 509190004003 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 509190004004 Ligand binding site; other site 509190004005 DXD motif; other site 509190004006 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 509190004007 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 509190004008 Prostaglandin dehydrogenases; Region: PGDH; cd05288 509190004009 NAD(P) binding site [chemical binding]; other site 509190004010 substrate binding site [chemical binding]; other site 509190004011 dimer interface [polypeptide binding]; other site 509190004012 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 509190004013 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 509190004014 putative catalytic site [active] 509190004015 putative phosphate binding site [ion binding]; other site 509190004016 active site 509190004017 metal binding site A [ion binding]; metal-binding site 509190004018 DNA binding site [nucleotide binding] 509190004019 putative AP binding site [nucleotide binding]; other site 509190004020 putative metal binding site B [ion binding]; other site 509190004021 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 509190004022 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 509190004023 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 509190004024 Zn2+ binding site [ion binding]; other site 509190004025 Mg2+ binding site [ion binding]; other site 509190004026 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 509190004027 Sporulation related domain; Region: SPOR; pfam05036 509190004028 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 509190004029 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 509190004030 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 509190004031 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 509190004032 Pyruvate dehydrogenase E1 component subunit alpha; Region: PLN02269 509190004033 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 509190004034 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 509190004035 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 509190004036 seryl-tRNA synthetase; Provisional; Region: PRK05431 509190004037 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 509190004038 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 509190004039 dimer interface [polypeptide binding]; other site 509190004040 active site 509190004041 motif 1; other site 509190004042 motif 2; other site 509190004043 motif 3; other site 509190004044 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 509190004045 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 509190004046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190004047 S-adenosylmethionine binding site [chemical binding]; other site 509190004048 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 509190004049 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 509190004050 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 509190004051 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 509190004052 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 509190004053 Peptidase family M23; Region: Peptidase_M23; pfam01551 509190004054 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 509190004055 Protein of unknown function (DUF815); Region: DUF815; pfam05673 509190004056 Preprotein translocase subunit; Region: YajC; pfam02699 509190004057 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 509190004058 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 509190004059 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 509190004060 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 509190004061 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 509190004062 Protein export membrane protein; Region: SecD_SecF; pfam02355 509190004063 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 509190004064 Protein of unknown function (DUF989); Region: DUF989; pfam06181 509190004065 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 509190004066 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 509190004067 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509190004068 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 509190004069 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 509190004070 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 509190004071 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 509190004072 binding surface 509190004073 TPR motif; other site 509190004074 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 509190004075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509190004076 Walker A/P-loop; other site 509190004077 ATP binding site [chemical binding]; other site 509190004078 Q-loop/lid; other site 509190004079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509190004080 ABC transporter signature motif; other site 509190004081 Walker B; other site 509190004082 D-loop; other site 509190004083 H-loop/switch region; other site 509190004084 Ligase N family; Region: LIGANc; smart00532 509190004085 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 509190004086 nucleotide binding pocket [chemical binding]; other site 509190004087 K-X-D-G motif; other site 509190004088 catalytic site [active] 509190004089 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 509190004090 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 509190004091 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 509190004092 Dimer interface [polypeptide binding]; other site 509190004093 BRCT sequence motif; other site 509190004094 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 509190004095 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 509190004096 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 509190004097 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 509190004098 active site 509190004099 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 509190004100 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 509190004101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190004102 S-adenosylmethionine binding site [chemical binding]; other site 509190004103 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 509190004104 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 509190004105 Part of AAA domain; Region: AAA_19; pfam13245 509190004106 Family description; Region: UvrD_C_2; pfam13538 509190004107 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 509190004108 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 509190004109 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509190004110 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 509190004111 putative C-terminal domain interface [polypeptide binding]; other site 509190004112 putative GSH binding site (G-site) [chemical binding]; other site 509190004113 putative dimer interface [polypeptide binding]; other site 509190004114 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 509190004115 N-terminal domain interface [polypeptide binding]; other site 509190004116 dimer interface [polypeptide binding]; other site 509190004117 substrate binding pocket (H-site) [chemical binding]; other site 509190004118 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509190004119 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 509190004120 C-terminal domain interface [polypeptide binding]; other site 509190004121 GSH binding site (G-site) [chemical binding]; other site 509190004122 dimer interface [polypeptide binding]; other site 509190004123 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 509190004124 dimer interface [polypeptide binding]; other site 509190004125 N-terminal domain interface [polypeptide binding]; other site 509190004126 substrate binding pocket (H-site) [chemical binding]; other site 509190004127 aspartate aminotransferase; Provisional; Region: PRK05764 509190004128 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509190004129 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190004130 homodimer interface [polypeptide binding]; other site 509190004131 catalytic residue [active] 509190004132 Predicted flavoprotein [General function prediction only]; Region: COG0431 509190004133 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 509190004134 Uncharacterized conserved protein [Function unknown]; Region: COG0398 509190004135 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 509190004136 2-isopropylmalate synthase; Validated; Region: PRK00915 509190004137 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 509190004138 active site 509190004139 catalytic residues [active] 509190004140 metal binding site [ion binding]; metal-binding site 509190004141 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 509190004142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190004143 S-adenosylmethionine binding site [chemical binding]; other site 509190004144 rod shape-determining protein MreB; Provisional; Region: PRK13927 509190004145 MreB and similar proteins; Region: MreB_like; cd10225 509190004146 nucleotide binding site [chemical binding]; other site 509190004147 Mg binding site [ion binding]; other site 509190004148 putative protofilament interaction site [polypeptide binding]; other site 509190004149 RodZ interaction site [polypeptide binding]; other site 509190004150 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 509190004151 rod shape-determining protein MreC; Region: MreC; pfam04085 509190004152 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 509190004153 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 509190004154 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 509190004155 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 509190004156 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 509190004157 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 509190004158 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 509190004159 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 509190004160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190004161 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 509190004162 putative substrate translocation pore; other site 509190004163 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 509190004164 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 509190004165 Phosphotransferase enzyme family; Region: APH; pfam01636 509190004166 putative active site [active] 509190004167 putative substrate binding site [chemical binding]; other site 509190004168 ATP binding site [chemical binding]; other site 509190004169 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 509190004170 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 509190004171 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 509190004172 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 509190004173 elongation factor Tu; Reviewed; Region: PRK00049 509190004174 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 509190004175 G1 box; other site 509190004176 GEF interaction site [polypeptide binding]; other site 509190004177 GTP/Mg2+ binding site [chemical binding]; other site 509190004178 Switch I region; other site 509190004179 G2 box; other site 509190004180 G3 box; other site 509190004181 Switch II region; other site 509190004182 G4 box; other site 509190004183 G5 box; other site 509190004184 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 509190004185 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 509190004186 Antibiotic Binding Site [chemical binding]; other site 509190004187 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190004188 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 509190004189 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190004190 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 509190004191 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 509190004192 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 509190004193 ligand binding site [chemical binding]; other site 509190004194 flexible hinge region; other site 509190004195 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 509190004196 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 509190004197 Uncharacterized protein required for formate dehydrogenase activity [Energy production and conversion]; Region: FdhD; COG1526 509190004198 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 509190004199 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 509190004200 putative molybdopterin cofactor binding site [chemical binding]; other site 509190004201 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 509190004202 putative molybdopterin cofactor binding site; other site 509190004203 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 509190004204 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 509190004205 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 509190004206 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 509190004207 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 509190004208 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 509190004209 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 509190004210 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 509190004211 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 509190004212 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 509190004213 putative translocon binding site; other site 509190004214 protein-rRNA interface [nucleotide binding]; other site 509190004215 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 509190004216 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 509190004217 G-X-X-G motif; other site 509190004218 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 509190004219 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 509190004220 23S rRNA interface [nucleotide binding]; other site 509190004221 5S rRNA interface [nucleotide binding]; other site 509190004222 putative antibiotic binding site [chemical binding]; other site 509190004223 L25 interface [polypeptide binding]; other site 509190004224 L27 interface [polypeptide binding]; other site 509190004225 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 509190004226 23S rRNA interface [nucleotide binding]; other site 509190004227 putative translocon interaction site; other site 509190004228 signal recognition particle (SRP54) interaction site; other site 509190004229 L23 interface [polypeptide binding]; other site 509190004230 trigger factor interaction site; other site 509190004231 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 509190004232 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 509190004233 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 509190004234 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 509190004235 RNA binding site [nucleotide binding]; other site 509190004236 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 509190004237 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 509190004238 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 509190004239 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 509190004240 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 509190004241 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 509190004242 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 509190004243 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 509190004244 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 509190004245 23S rRNA interface [nucleotide binding]; other site 509190004246 L21e interface [polypeptide binding]; other site 509190004247 5S rRNA interface [nucleotide binding]; other site 509190004248 L27 interface [polypeptide binding]; other site 509190004249 L5 interface [polypeptide binding]; other site 509190004250 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 509190004251 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 509190004252 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 509190004253 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 509190004254 23S rRNA binding site [nucleotide binding]; other site 509190004255 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 509190004256 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 509190004257 SecY translocase; Region: SecY; pfam00344 509190004258 adenylate kinase; Provisional; Region: PRK14532 509190004259 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 509190004260 AMP-binding site [chemical binding]; other site 509190004261 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 509190004262 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 509190004263 30S ribosomal protein S13; Region: bact_S13; TIGR03631 509190004264 30S ribosomal protein S11; Validated; Region: PRK05309 509190004265 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 509190004266 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 509190004267 alphaNTD - beta interaction site [polypeptide binding]; other site 509190004268 alphaNTD homodimer interface [polypeptide binding]; other site 509190004269 alphaNTD - beta' interaction site [polypeptide binding]; other site 509190004270 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 509190004271 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 509190004272 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 509190004273 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509190004274 Walker A/P-loop; other site 509190004275 ATP binding site [chemical binding]; other site 509190004276 Q-loop/lid; other site 509190004277 ABC transporter signature motif; other site 509190004278 Walker B; other site 509190004279 D-loop; other site 509190004280 H-loop/switch region; other site 509190004281 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 509190004282 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 509190004283 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 509190004284 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 509190004285 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 509190004286 Protein of unknown function (DUF419); Region: DUF419; pfam04237 509190004287 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509190004288 dimerization interface [polypeptide binding]; other site 509190004289 putative DNA binding site [nucleotide binding]; other site 509190004290 putative Zn2+ binding site [ion binding]; other site 509190004291 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 509190004292 hydrophobic ligand binding site; other site 509190004293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190004294 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509190004295 putative substrate translocation pore; other site 509190004296 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 509190004297 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 509190004298 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 509190004299 protein binding site [polypeptide binding]; other site 509190004300 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 509190004301 protein binding site [polypeptide binding]; other site 509190004302 recombination factor protein RarA; Reviewed; Region: PRK13342 509190004303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509190004304 Walker A motif; other site 509190004305 ATP binding site [chemical binding]; other site 509190004306 Walker B motif; other site 509190004307 arginine finger; other site 509190004308 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 509190004309 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 509190004310 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 509190004311 active site 509190004312 camphor resistance protein CrcB; Provisional; Region: PRK14195 509190004313 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 509190004314 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 509190004315 active site 509190004316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 509190004317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5267 509190004318 ATP12 chaperone protein; Region: ATP12; cl02228 509190004319 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 509190004320 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 509190004321 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 509190004322 Predicted membrane protein [Function unknown]; Region: COG3174 509190004323 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 509190004324 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 509190004325 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 509190004326 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 509190004327 active site 509190004328 HIGH motif; other site 509190004329 KMSKS motif; other site 509190004330 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 509190004331 tRNA binding surface [nucleotide binding]; other site 509190004332 anticodon binding site; other site 509190004333 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 509190004334 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 509190004335 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 509190004336 CysD dimerization site [polypeptide binding]; other site 509190004337 G1 box; other site 509190004338 putative GEF interaction site [polypeptide binding]; other site 509190004339 GTP/Mg2+ binding site [chemical binding]; other site 509190004340 Switch I region; other site 509190004341 G2 box; other site 509190004342 G3 box; other site 509190004343 Switch II region; other site 509190004344 G4 box; other site 509190004345 G5 box; other site 509190004346 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 509190004347 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 509190004348 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 509190004349 ligand-binding site [chemical binding]; other site 509190004350 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 509190004351 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 509190004352 Active Sites [active] 509190004353 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 509190004354 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 509190004355 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 509190004356 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 509190004357 galactarate dehydratase; Region: galactar-dH20; TIGR03248 509190004358 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 509190004359 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 509190004360 Transcriptional regulators [Transcription]; Region: PurR; COG1609 509190004361 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 509190004362 DNA binding site [nucleotide binding] 509190004363 domain linker motif; other site 509190004364 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 509190004365 putative dimerization interface [polypeptide binding]; other site 509190004366 putative ligand binding site [chemical binding]; other site 509190004367 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 509190004368 glucuronate isomerase; Reviewed; Region: PRK02925 509190004369 KduI/IolB family; Region: KduI; cl01508 509190004370 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 509190004371 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 509190004372 NADP binding site [chemical binding]; other site 509190004373 homodimer interface [polypeptide binding]; other site 509190004374 active site 509190004375 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 509190004376 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 509190004377 active site 509190004378 intersubunit interface [polypeptide binding]; other site 509190004379 catalytic residue [active] 509190004380 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 509190004381 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 509190004382 substrate binding site [chemical binding]; other site 509190004383 ATP binding site [chemical binding]; other site 509190004384 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 509190004385 DNA binding residues [nucleotide binding] 509190004386 dimerization interface [polypeptide binding]; other site 509190004387 Bacterial Ig-like domain; Region: Big_5; pfam13205 509190004388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 509190004389 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 509190004390 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509190004391 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 509190004392 putative active site [active] 509190004393 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 509190004394 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 509190004395 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 509190004396 CsbD-like; Region: CsbD; pfam05532 509190004397 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 509190004398 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 509190004399 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190004400 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190004401 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190004402 ligand-binding site [chemical binding]; other site 509190004403 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 509190004404 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 509190004405 putative oxidoreductase; Provisional; Region: PRK11579 509190004406 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 509190004407 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 509190004408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190004409 D-galactonate transporter; Region: 2A0114; TIGR00893 509190004410 putative substrate translocation pore; other site 509190004411 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 509190004412 Predicted transcriptional regulator [Transcription]; Region: COG3682 509190004413 Helix-turn-helix domain; Region: HTH_18; pfam12833 509190004414 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190004415 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 509190004416 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 509190004417 active site 509190004418 homotetramer interface [polypeptide binding]; other site 509190004419 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 509190004420 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 509190004421 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190004422 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 509190004423 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 509190004424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 509190004425 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 509190004426 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 509190004427 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 509190004428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 509190004429 Peptidase M15; Region: Peptidase_M15_3; cl01194 509190004430 Uncharacterized conserved protein [Function unknown]; Region: COG3791 509190004431 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 509190004432 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 509190004433 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 509190004434 homodimer interface [polypeptide binding]; other site 509190004435 Walker A motif; other site 509190004436 ATP binding site [chemical binding]; other site 509190004437 hydroxycobalamin binding site [chemical binding]; other site 509190004438 Walker B motif; other site 509190004439 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 509190004440 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 509190004441 AbgT putative transporter family; Region: ABG_transport; cl17431 509190004442 Transglycosylase; Region: Transgly; pfam00912 509190004443 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 509190004444 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 509190004445 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 509190004446 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 509190004447 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 509190004448 Cu(I) binding site [ion binding]; other site 509190004449 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190004450 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190004451 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 509190004452 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 509190004453 FMN binding site [chemical binding]; other site 509190004454 active site 509190004455 catalytic residues [active] 509190004456 substrate binding site [chemical binding]; other site 509190004457 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 509190004458 catalytic motif [active] 509190004459 Catalytic residue [active] 509190004460 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 509190004461 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 509190004462 putative dimer interface [polypeptide binding]; other site 509190004463 NaMN:DMB phosphoribosyltransferase [Coenzyme metabolism]; Region: CobT; COG2038 509190004464 active site pocket [active] 509190004465 putative cataytic base [active] 509190004466 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 509190004467 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509190004468 active site 509190004469 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 509190004470 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 509190004471 active site 509190004472 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 509190004473 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 509190004474 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 509190004475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509190004476 Walker A/P-loop; other site 509190004477 ATP binding site [chemical binding]; other site 509190004478 Q-loop/lid; other site 509190004479 ABC transporter signature motif; other site 509190004480 Walker B; other site 509190004481 D-loop; other site 509190004482 H-loop/switch region; other site 509190004483 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 509190004484 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 509190004485 dimer interface [polypeptide binding]; other site 509190004486 active site 509190004487 metal binding site [ion binding]; metal-binding site 509190004488 glutathione binding site [chemical binding]; other site 509190004489 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509190004490 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 509190004491 C-terminal domain interface [polypeptide binding]; other site 509190004492 GSH binding site (G-site) [chemical binding]; other site 509190004493 dimer interface [polypeptide binding]; other site 509190004494 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 509190004495 dimer interface [polypeptide binding]; other site 509190004496 N-terminal domain interface [polypeptide binding]; other site 509190004497 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 509190004498 Protein of unknown function, DUF608; Region: DUF608; pfam04685 509190004499 Trehalase; Region: Trehalase; cl17346 509190004500 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 509190004501 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 509190004502 putative ADP-binding pocket [chemical binding]; other site 509190004503 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 509190004504 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 509190004505 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 509190004506 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 509190004507 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 509190004508 HIGH motif; other site 509190004509 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 509190004510 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 509190004511 active site 509190004512 KMSKS motif; other site 509190004513 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 509190004514 tRNA binding surface [nucleotide binding]; other site 509190004515 anticodon binding site; other site 509190004516 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 509190004517 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 509190004518 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 509190004519 Beta-lactamase; Region: Beta-lactamase; pfam00144 509190004520 TPR repeat; Region: TPR_11; pfam13414 509190004521 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 509190004522 TPR motif; other site 509190004523 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 509190004524 amidase; Provisional; Region: PRK07869 509190004525 Amidase; Region: Amidase; cl11426 509190004526 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 509190004527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190004528 S-adenosylmethionine binding site [chemical binding]; other site 509190004529 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 509190004530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190004531 S-adenosylmethionine binding site [chemical binding]; other site 509190004532 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 509190004533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 509190004534 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 509190004535 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509190004536 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 509190004537 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 509190004538 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 509190004539 N-acetyl-D-glucosamine binding site [chemical binding]; other site 509190004540 catalytic residue [active] 509190004541 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 509190004542 Fe-S cluster binding site [ion binding]; other site 509190004543 active site 509190004544 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 509190004545 hydroxyglutarate oxidase; Provisional; Region: PRK11728 509190004546 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 509190004547 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 509190004548 TPR motif; other site 509190004549 binding surface 509190004550 TPR repeat; Region: TPR_11; pfam13414 509190004551 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 509190004552 binding surface 509190004553 TPR motif; other site 509190004554 TPR repeat; Region: TPR_11; pfam13414 509190004555 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 509190004556 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 509190004557 active site 509190004558 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 509190004559 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 509190004560 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 509190004561 Nitrogen regulatory protein P-II; Region: P-II; smart00938 509190004562 Protein of unknown function, DUF486; Region: DUF486; cl01236 509190004563 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 509190004564 Fasciclin domain; Region: Fasciclin; pfam02469 509190004565 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 509190004566 motif 1; other site 509190004567 dimer interface [polypeptide binding]; other site 509190004568 active site 509190004569 motif 2; other site 509190004570 motif 3; other site 509190004571 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 509190004572 Cytochrome c; Region: Cytochrom_C; cl11414 509190004573 Cytochrome c553 [Energy production and conversion]; Region: COG2863 509190004574 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 509190004575 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 509190004576 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 509190004577 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190004578 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190004579 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 509190004580 nudix motif; other site 509190004581 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 509190004582 Beta-lactamase; Region: Beta-lactamase; pfam00144 509190004583 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509190004584 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190004585 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 509190004586 dimer interface [polypeptide binding]; other site 509190004587 allosteric magnesium binding site [ion binding]; other site 509190004588 active site 509190004589 aspartate-rich active site metal binding site; other site 509190004590 Schiff base residues; other site 509190004591 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 509190004592 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 509190004593 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 509190004594 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509190004595 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 509190004596 substrate binding pocket [chemical binding]; other site 509190004597 FAD binding site [chemical binding]; other site 509190004598 catalytic base [active] 509190004599 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 509190004600 catalytic core [active] 509190004601 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 509190004602 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509190004603 substrate binding site [chemical binding]; other site 509190004604 oxyanion hole (OAH) forming residues; other site 509190004605 trimer interface [polypeptide binding]; other site 509190004606 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 509190004607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190004608 S-adenosylmethionine binding site [chemical binding]; other site 509190004609 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 509190004610 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 509190004611 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 509190004612 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 509190004613 substrate-cofactor binding pocket; other site 509190004614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190004615 catalytic residue [active] 509190004616 Predicted transcriptional regulator [Transcription]; Region: COG4957 509190004617 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 509190004618 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 509190004619 dimer interface [polypeptide binding]; other site 509190004620 active site 509190004621 glycine-pyridoxal phosphate binding site [chemical binding]; other site 509190004622 folate binding site [chemical binding]; other site 509190004623 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 509190004624 ATP cone domain; Region: ATP-cone; pfam03477 509190004625 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 509190004626 homopentamer interface [polypeptide binding]; other site 509190004627 active site 509190004628 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 509190004629 putative RNA binding site [nucleotide binding]; other site 509190004630 thiamine-monophosphate kinase; Region: thiL; TIGR01379 509190004631 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 509190004632 ATP binding site [chemical binding]; other site 509190004633 dimerization interface [polypeptide binding]; other site 509190004634 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808 509190004635 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 509190004636 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 509190004637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190004638 active site 509190004639 phosphorylation site [posttranslational modification] 509190004640 intermolecular recognition site; other site 509190004641 dimerization interface [polypeptide binding]; other site 509190004642 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 509190004643 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 509190004644 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 509190004645 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 509190004646 putative phosphate acyltransferase; Provisional; Region: PRK05331 509190004647 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 509190004648 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 509190004649 dimer interface [polypeptide binding]; other site 509190004650 active site 509190004651 CoA binding pocket [chemical binding]; other site 509190004652 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 509190004653 IHF dimer interface [polypeptide binding]; other site 509190004654 IHF - DNA interface [nucleotide binding]; other site 509190004655 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 509190004656 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 509190004657 DNA binding residues [nucleotide binding] 509190004658 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 509190004659 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 509190004660 dimer interface [polypeptide binding]; other site 509190004661 Alkaline phosphatase homologues; Region: alkPPc; smart00098 509190004662 active site 509190004663 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 509190004664 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 509190004665 23S rRNA interface [nucleotide binding]; other site 509190004666 L3 interface [polypeptide binding]; other site 509190004667 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 509190004668 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 509190004669 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 509190004670 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 509190004671 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 509190004672 aminotransferase; Validated; Region: PRK09148 509190004673 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509190004674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190004675 homodimer interface [polypeptide binding]; other site 509190004676 catalytic residue [active] 509190004677 homoserine dehydrogenase; Provisional; Region: PRK06349 509190004678 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 509190004679 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 509190004680 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 509190004681 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 509190004682 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 509190004683 putative active site [active] 509190004684 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 509190004685 metal binding site [ion binding]; metal-binding site 509190004686 active site 509190004687 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 509190004688 DHH family; Region: DHH; pfam01368 509190004689 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 509190004690 DNA-binding site [nucleotide binding]; DNA binding site 509190004691 RNA-binding motif; other site 509190004692 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 509190004693 DNA-binding site [nucleotide binding]; DNA binding site 509190004694 RNA-binding motif; other site 509190004695 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 509190004696 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 509190004697 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 509190004698 active site 509190004699 AAA domain; Region: AAA_21; pfam13304 509190004700 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 509190004701 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 509190004702 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659 509190004703 5' RNA guide strand anchoring site; other site 509190004704 active site 509190004705 SIR2-like domain; Region: SIR2_2; pfam13289 509190004706 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 509190004707 Domain of unknown function (DUF955); Region: DUF955; pfam06114 509190004708 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509190004709 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190004710 LysR substrate binding domain; Region: LysR_substrate; pfam03466 509190004711 dimerization interface [polypeptide binding]; other site 509190004712 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 509190004713 homotrimer interaction site [polypeptide binding]; other site 509190004714 putative active site [active] 509190004715 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190004716 PAS domain; Region: PAS_9; pfam13426 509190004717 putative active site [active] 509190004718 heme pocket [chemical binding]; other site 509190004719 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190004720 PAS domain; Region: PAS_9; pfam13426 509190004721 putative active site [active] 509190004722 heme pocket [chemical binding]; other site 509190004723 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 509190004724 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190004725 dimer interface [polypeptide binding]; other site 509190004726 putative CheW interface [polypeptide binding]; other site 509190004727 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 509190004728 GAF domain; Region: GAF; pfam01590 509190004729 Catalytic site; other site 509190004730 Staphylococcal nuclease homologue; Region: SNase; pfam00565 509190004731 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 509190004732 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 509190004733 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 509190004734 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 509190004735 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 509190004736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190004737 putative substrate translocation pore; other site 509190004738 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 509190004739 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 509190004740 NAD(P) binding site [chemical binding]; other site 509190004741 catalytic residues [active] 509190004742 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509190004743 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509190004744 active site 509190004745 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 509190004746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190004747 NAD(P) binding site [chemical binding]; other site 509190004748 active site 509190004749 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 509190004750 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190004751 N-terminal plug; other site 509190004752 ligand-binding site [chemical binding]; other site 509190004753 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509190004754 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509190004755 active site 509190004756 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190004757 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190004758 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 509190004759 short chain dehydrogenase; Provisional; Region: PRK12939 509190004760 hypothetical protein; Provisional; Region: PRK06194 509190004761 classical (c) SDRs; Region: SDR_c; cd05233 509190004762 NAD(P) binding site [chemical binding]; other site 509190004763 active site 509190004764 Transcriptional regulator [Transcription]; Region: IclR; COG1414 509190004765 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 509190004766 hypothetical protein; Provisional; Region: PRK06194 509190004767 classical (c) SDRs; Region: SDR_c; cd05233 509190004768 NAD(P) binding site [chemical binding]; other site 509190004769 active site 509190004770 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 509190004771 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 509190004772 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 509190004773 DNA-binding site [nucleotide binding]; DNA binding site 509190004774 Transcriptional regulators [Transcription]; Region: FadR; COG2186 509190004775 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 509190004776 DNA-binding site [nucleotide binding]; DNA binding site 509190004777 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 509190004778 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509190004779 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 509190004780 ALDH subfamily: NAD(P)+-dependent benzaldehyde dehydrogenase II, vanillin dehydrogenase, p-hydroxybenzaldehyde dehydrogenase and related proteins; Region: ALDH_BenzADH-like; cd07104 509190004781 NAD(P) binding site [chemical binding]; other site 509190004782 catalytic residues [active] 509190004783 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 509190004784 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 509190004785 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 509190004786 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 509190004787 active site 509190004788 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 509190004789 active site 509190004790 metal binding site [ion binding]; metal-binding site 509190004791 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 509190004792 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 509190004793 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 509190004794 TrkA-N domain; Region: TrkA_N; pfam02254 509190004795 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 509190004796 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 509190004797 Transcriptional regulator [Transcription]; Region: IclR; COG1414 509190004798 Bacterial transcriptional regulator; Region: IclR; pfam01614 509190004799 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 509190004800 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 509190004801 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 509190004802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190004803 NAD(P) binding site [chemical binding]; other site 509190004804 active site 509190004805 Transcriptional regulators [Transcription]; Region: FadR; COG2186 509190004806 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509190004807 DNA-binding site [nucleotide binding]; DNA binding site 509190004808 Transcriptional regulators [Transcription]; Region: FadR; COG2186 509190004809 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509190004810 DNA-binding site [nucleotide binding]; DNA binding site 509190004811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190004812 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509190004813 putative substrate translocation pore; other site 509190004814 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 509190004815 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190004816 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190004817 N-terminal plug; other site 509190004818 ligand-binding site [chemical binding]; other site 509190004819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190004820 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509190004821 putative substrate translocation pore; other site 509190004822 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190004823 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190004824 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 509190004825 MASE1; Region: MASE1; cl17823 509190004826 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509190004827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190004828 dimer interface [polypeptide binding]; other site 509190004829 phosphorylation site [posttranslational modification] 509190004830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190004831 ATP binding site [chemical binding]; other site 509190004832 Mg2+ binding site [ion binding]; other site 509190004833 G-X-G motif; other site 509190004834 Response regulator receiver domain; Region: Response_reg; pfam00072 509190004835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190004836 active site 509190004837 phosphorylation site [posttranslational modification] 509190004838 intermolecular recognition site; other site 509190004839 dimerization interface [polypeptide binding]; other site 509190004840 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 509190004841 DNA binding residues [nucleotide binding] 509190004842 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 509190004843 dimer interface [polypeptide binding]; other site 509190004844 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 509190004845 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 509190004846 dimer interface [polypeptide binding]; other site 509190004847 active site 509190004848 Coenzyme A transferase; Region: CoA_trans; cl17247 509190004849 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 509190004850 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 509190004851 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 509190004852 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 509190004853 Protein export membrane protein; Region: SecD_SecF; cl14618 509190004854 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 509190004855 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 509190004856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190004857 active site 509190004858 phosphorylation site [posttranslational modification] 509190004859 intermolecular recognition site; other site 509190004860 dimerization interface [polypeptide binding]; other site 509190004861 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509190004862 DNA binding site [nucleotide binding] 509190004863 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509190004864 HAMP domain; Region: HAMP; pfam00672 509190004865 dimerization interface [polypeptide binding]; other site 509190004866 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190004867 dimer interface [polypeptide binding]; other site 509190004868 phosphorylation site [posttranslational modification] 509190004869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190004870 ATP binding site [chemical binding]; other site 509190004871 Mg2+ binding site [ion binding]; other site 509190004872 G-X-G motif; other site 509190004873 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 509190004874 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 509190004875 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 509190004876 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 509190004877 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 509190004878 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 509190004879 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 509190004880 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 509190004881 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 509190004882 phosphate binding site [ion binding]; other site 509190004883 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 509190004884 classical (c) SDRs; Region: SDR_c; cd05233 509190004885 NAD(P) binding site [chemical binding]; other site 509190004886 active site 509190004887 Transcriptional regulator [Transcription]; Region: IclR; COG1414 509190004888 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 509190004889 Bacterial transcriptional regulator; Region: IclR; pfam01614 509190004890 L-rhamnonate dehydratase; Provisional; Region: PRK15440 509190004891 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 509190004892 putative active site pocket [active] 509190004893 putative metal binding site [ion binding]; other site 509190004894 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 509190004895 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 509190004896 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 509190004897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190004898 NAD(P) binding site [chemical binding]; other site 509190004899 active site 509190004900 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 509190004901 Amidohydrolase; Region: Amidohydro_2; pfam04909 509190004902 active site 509190004903 rhamnose-proton symporter; Provisional; Region: PRK13499 509190004904 Transcriptional regulator [Transcription]; Region: IclR; COG1414 509190004905 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 509190004906 Bacterial transcriptional regulator; Region: IclR; pfam01614 509190004907 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190004908 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190004909 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190004910 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190004911 N-terminal plug; other site 509190004912 ligand-binding site [chemical binding]; other site 509190004913 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 509190004914 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 509190004915 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190004916 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190004917 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 509190004918 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 509190004919 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 509190004920 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 509190004921 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 509190004922 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509190004923 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190004924 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 509190004925 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190004926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190004927 pyrimidine utilization protein A; Region: RutA; TIGR03612 509190004928 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 509190004929 active site 509190004930 dimer interface [polypeptide binding]; other site 509190004931 non-prolyl cis peptide bond; other site 509190004932 insertion regions; other site 509190004933 Isochorismatase family; Region: Isochorismatase; pfam00857 509190004934 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 509190004935 catalytic triad [active] 509190004936 conserved cis-peptide bond; other site 509190004937 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 509190004938 putative metal binding site [ion binding]; other site 509190004939 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 509190004940 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 509190004941 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 509190004942 extended (e) SDRs; Region: SDR_e; cd08946 509190004943 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 509190004944 NAD(P) binding site [chemical binding]; other site 509190004945 active site 509190004946 substrate binding site [chemical binding]; other site 509190004947 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 509190004948 active site 509190004949 metal binding site [ion binding]; metal-binding site 509190004950 short chain dehydrogenase; Provisional; Region: PRK06180 509190004951 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 509190004952 NADP binding site [chemical binding]; other site 509190004953 active site 509190004954 steroid binding site; other site 509190004955 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 509190004956 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 509190004957 active site 509190004958 iron coordination sites [ion binding]; other site 509190004959 substrate binding pocket [chemical binding]; other site 509190004960 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 509190004961 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 509190004962 [2Fe-2S] cluster binding site [ion binding]; other site 509190004963 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 509190004964 putative alpha subunit interface [polypeptide binding]; other site 509190004965 putative active site [active] 509190004966 putative substrate binding site [chemical binding]; other site 509190004967 Fe binding site [ion binding]; other site 509190004968 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 509190004969 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 509190004970 putative active site [active] 509190004971 metal binding site [ion binding]; metal-binding site 509190004972 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 509190004973 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509190004974 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190004975 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509190004976 Serine hydrolase; Region: Ser_hydrolase; cl17834 509190004977 Cupin domain; Region: Cupin_2; pfam07883 509190004978 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 509190004979 active site 509190004980 Cytochrome c; Region: Cytochrom_C; pfam00034 509190004981 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 509190004982 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 509190004983 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 509190004984 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 509190004985 catalytic loop [active] 509190004986 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 509190004987 iron binding site [ion binding]; other site 509190004988 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 509190004989 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 509190004990 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 509190004991 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 509190004992 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 509190004993 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 509190004994 YHS domain; Region: YHS; pfam04945 509190004995 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 509190004996 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 509190004997 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 509190004998 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 509190004999 DNA binding residues [nucleotide binding] 509190005000 methionine synthase; Provisional; Region: PRK01207 509190005001 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 509190005002 substrate binding site [chemical binding]; other site 509190005003 THF binding site; other site 509190005004 zinc-binding site [ion binding]; other site 509190005005 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 509190005006 Cupin; Region: Cupin_6; pfam12852 509190005007 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509190005008 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190005009 short chain dehydrogenase; Provisional; Region: PRK06179 509190005010 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 509190005011 NADP binding site [chemical binding]; other site 509190005012 active site 509190005013 steroid binding site; other site 509190005014 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 509190005015 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 509190005016 Secretin and TonB N terminus short domain; Region: STN; smart00965 509190005017 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190005018 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190005019 N-terminal plug; other site 509190005020 ligand-binding site [chemical binding]; other site 509190005021 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 509190005022 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509190005023 DNA binding residues [nucleotide binding] 509190005024 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 509190005025 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509190005026 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509190005027 DNA binding residues [nucleotide binding] 509190005028 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 509190005029 FecR protein; Region: FecR; pfam04773 509190005030 Secretin and TonB N terminus short domain; Region: STN; smart00965 509190005031 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190005032 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190005033 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190005034 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 509190005035 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 509190005036 active site 509190005037 PHP-associated; Region: PHP_C; pfam13263 509190005038 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 509190005039 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 509190005040 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 509190005041 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 509190005042 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 509190005043 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 509190005044 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 509190005045 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 509190005046 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190005047 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190005048 Transcriptional regulator [Transcription]; Region: IclR; COG1414 509190005049 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 509190005050 Bacterial transcriptional regulator; Region: IclR; pfam01614 509190005051 Domain of unknown function (DUF718); Region: DUF718; cl01281 509190005052 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 509190005053 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 509190005054 short chain dehydrogenase; Provisional; Region: PRK06138 509190005055 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 509190005056 NAD binding site [chemical binding]; other site 509190005057 homotetramer interface [polypeptide binding]; other site 509190005058 homodimer interface [polypeptide binding]; other site 509190005059 active site 509190005060 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 509190005061 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 509190005062 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 509190005063 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 509190005064 active site 509190005065 catalytic tetrad [active] 509190005066 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 509190005067 Amidohydrolase; Region: Amidohydro_2; pfam04909 509190005068 active site 509190005069 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 509190005070 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 509190005071 putative NAD(P) binding site [chemical binding]; other site 509190005072 catalytic Zn binding site [ion binding]; other site 509190005073 structural Zn binding site [ion binding]; other site 509190005074 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 509190005075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190005076 putative substrate translocation pore; other site 509190005077 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 509190005078 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 509190005079 alpha-galactosidase; Region: PLN02808; cl17638 509190005080 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 509190005081 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 509190005082 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 509190005083 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 509190005084 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 509190005085 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 509190005086 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 509190005087 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 509190005088 Predicted transcriptional regulator [Transcription]; Region: COG3682 509190005089 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 509190005090 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509190005091 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509190005092 DNA binding residues [nucleotide binding] 509190005093 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 509190005094 FecR protein; Region: FecR; pfam04773 509190005095 Secretin and TonB N terminus short domain; Region: STN; smart00965 509190005096 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 509190005097 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190005098 N-terminal plug; other site 509190005099 ligand-binding site [chemical binding]; other site 509190005100 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 509190005101 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 509190005102 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 509190005103 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 509190005104 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 509190005105 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 509190005106 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 509190005107 active site 509190005108 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 509190005109 FtsX-like permease family; Region: FtsX; pfam02687 509190005110 FtsX-like permease family; Region: FtsX; pfam02687 509190005111 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 509190005112 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 509190005113 Walker A/P-loop; other site 509190005114 ATP binding site [chemical binding]; other site 509190005115 Q-loop/lid; other site 509190005116 ABC transporter signature motif; other site 509190005117 Walker B; other site 509190005118 D-loop; other site 509190005119 H-loop/switch region; other site 509190005120 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 509190005121 active site 509190005122 catalytic triad [active] 509190005123 oxyanion hole [active] 509190005124 switch loop; other site 509190005125 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190005126 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190005127 N-terminal plug; other site 509190005128 ligand-binding site [chemical binding]; other site 509190005129 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 509190005130 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 509190005131 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 509190005132 Soluble P-type ATPase [General function prediction only]; Region: COG4087 509190005133 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 509190005134 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 509190005135 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 509190005136 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 509190005137 Ligand Binding Site [chemical binding]; other site 509190005138 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 509190005139 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190005140 dimer interface [polypeptide binding]; other site 509190005141 phosphorylation site [posttranslational modification] 509190005142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190005143 ATP binding site [chemical binding]; other site 509190005144 G-X-G motif; other site 509190005145 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 509190005146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190005147 active site 509190005148 phosphorylation site [posttranslational modification] 509190005149 intermolecular recognition site; other site 509190005150 dimerization interface [polypeptide binding]; other site 509190005151 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509190005152 DNA binding site [nucleotide binding] 509190005153 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 509190005154 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 509190005155 DNA binding residues [nucleotide binding] 509190005156 dimerization interface [polypeptide binding]; other site 509190005157 Transcriptional regulators [Transcription]; Region: FadR; COG2186 509190005158 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509190005159 DNA-binding site [nucleotide binding]; DNA binding site 509190005160 FCD domain; Region: FCD; pfam07729 509190005161 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 509190005162 AAA domain; Region: AAA_33; pfam13671 509190005163 ATP-binding site [chemical binding]; other site 509190005164 Gluconate-6-phosphate binding site [chemical binding]; other site 509190005165 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 509190005166 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 509190005167 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 509190005168 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 509190005169 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 509190005170 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 509190005171 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190005172 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190005173 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190005174 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 509190005175 transmembrane helices; other site 509190005176 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 509190005177 TrkA-C domain; Region: TrkA_C; pfam02080 509190005178 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 509190005179 TrkA-C domain; Region: TrkA_C; pfam02080 509190005180 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 509190005181 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 509190005182 Chain length determinant protein; Region: Wzz; pfam02706 509190005183 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 509190005184 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 509190005185 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 509190005186 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 509190005187 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 509190005188 Bacterial sugar transferase; Region: Bac_transf; pfam02397 509190005189 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 509190005190 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 509190005191 active site 509190005192 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 509190005193 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 509190005194 active site 509190005195 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 509190005196 putative translaldolase; Provisional; Region: PRK12376 509190005197 catalytic residue [active] 509190005198 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 509190005199 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509190005200 active site 509190005201 motif I; other site 509190005202 motif II; other site 509190005203 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 509190005204 dimer interface [polypeptide binding]; other site 509190005205 active site 509190005206 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 509190005207 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 509190005208 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 509190005209 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 509190005210 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 509190005211 Substrate binding site; other site 509190005212 Mg++ binding site; other site 509190005213 metal-binding site 509190005214 Mg++ binding site; other site 509190005215 metal-binding site 509190005216 transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392 509190005217 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 509190005218 ligand binding site [chemical binding]; other site 509190005219 flexible hinge region; other site 509190005220 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 509190005221 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 509190005222 Low-spin heme binding site [chemical binding]; other site 509190005223 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 509190005224 Putative water exit pathway; other site 509190005225 Binuclear center (active site) [active] 509190005226 Putative proton exit pathway; other site 509190005227 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 509190005228 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 509190005229 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 509190005230 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 509190005231 Cytochrome c; Region: Cytochrom_C; pfam00034 509190005232 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 509190005233 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 509190005234 4Fe-4S binding domain; Region: Fer4_5; pfam12801 509190005235 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 509190005236 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 509190005237 FixH; Region: FixH; pfam05751 509190005238 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 509190005239 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 509190005240 metal-binding site [ion binding] 509190005241 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 509190005242 Soluble P-type ATPase [General function prediction only]; Region: COG4087 509190005243 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 509190005244 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 509190005245 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509190005246 FeS/SAM binding site; other site 509190005247 HemN C-terminal domain; Region: HemN_C; pfam06969 509190005248 OmpW family; Region: OmpW; pfam03922 509190005249 pyrimidine utilization protein A; Region: RutA; TIGR03612 509190005250 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 509190005251 active site 509190005252 dimer interface [polypeptide binding]; other site 509190005253 non-prolyl cis peptide bond; other site 509190005254 insertion regions; other site 509190005255 Isochorismatase family; Region: Isochorismatase; pfam00857 509190005256 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 509190005257 catalytic triad [active] 509190005258 conserved cis-peptide bond; other site 509190005259 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 509190005260 active site 509190005261 catalytic residues [active] 509190005262 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 509190005263 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 509190005264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 509190005265 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 509190005266 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 509190005267 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 509190005268 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 509190005269 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 509190005270 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 509190005271 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 509190005272 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 509190005273 FMN binding site [chemical binding]; other site 509190005274 active site 509190005275 substrate binding site [chemical binding]; other site 509190005276 catalytic residue [active] 509190005277 mercuric reductase; Validated; Region: PRK06370 509190005278 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 509190005279 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509190005280 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 509190005281 Predicted membrane protein [Function unknown]; Region: COG3918 509190005282 cystathionine beta-lyase, bacterial; Region: cysta_beta_ly_B; TIGR01324 509190005283 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 509190005284 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509190005285 catalytic residue [active] 509190005286 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 509190005287 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 509190005288 active site residue [active] 509190005289 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 509190005290 active site residue [active] 509190005291 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 509190005292 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 509190005293 dimer interface [polypeptide binding]; other site 509190005294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190005295 catalytic residue [active] 509190005296 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 509190005297 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 509190005298 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 509190005299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190005300 S-adenosylmethionine binding site [chemical binding]; other site 509190005301 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 509190005302 DNA photolyase; Region: DNA_photolyase; pfam00875 509190005303 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 509190005304 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 509190005305 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 509190005306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190005307 NAD(P) binding site [chemical binding]; other site 509190005308 active site 509190005309 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 509190005310 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 509190005311 dimer interface [polypeptide binding]; other site 509190005312 active site 509190005313 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 509190005314 DUF35 OB-fold domain; Region: DUF35; pfam01796 509190005315 acetyl-CoA acetyltransferase; Validated; Region: PRK06157 509190005316 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 509190005317 active site 509190005318 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 509190005319 Phosphotransferase enzyme family; Region: APH; pfam01636 509190005320 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 509190005321 putative active site [active] 509190005322 putative substrate binding site [chemical binding]; other site 509190005323 ATP binding site [chemical binding]; other site 509190005324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 509190005325 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 509190005326 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 509190005327 generic binding surface II; other site 509190005328 ssDNA binding site; other site 509190005329 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509190005330 ATP binding site [chemical binding]; other site 509190005331 putative Mg++ binding site [ion binding]; other site 509190005332 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509190005333 nucleotide binding region [chemical binding]; other site 509190005334 ATP-binding site [chemical binding]; other site 509190005335 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 509190005336 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 509190005337 Walker A/P-loop; other site 509190005338 ATP binding site [chemical binding]; other site 509190005339 Q-loop/lid; other site 509190005340 ABC transporter signature motif; other site 509190005341 Walker B; other site 509190005342 D-loop; other site 509190005343 H-loop/switch region; other site 509190005344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509190005345 dimer interface [polypeptide binding]; other site 509190005346 conserved gate region; other site 509190005347 putative PBP binding loops; other site 509190005348 ABC-ATPase subunit interface; other site 509190005349 cystine transporter subunit; Provisional; Region: PRK11260 509190005350 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 509190005351 substrate binding pocket [chemical binding]; other site 509190005352 membrane-bound complex binding site; other site 509190005353 hinge residues; other site 509190005354 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 509190005355 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 509190005356 dimer interface [polypeptide binding]; other site 509190005357 active site 509190005358 CoA binding pocket [chemical binding]; other site 509190005359 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 509190005360 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 509190005361 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 509190005362 Putative esterase; Region: Esterase; pfam00756 509190005363 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 509190005364 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 509190005365 Universal stress protein family; Region: Usp; pfam00582 509190005366 Ligand Binding Site [chemical binding]; other site 509190005367 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 509190005368 Ligand Binding Site [chemical binding]; other site 509190005369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509190005370 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 509190005371 Walker A motif; other site 509190005372 ATP binding site [chemical binding]; other site 509190005373 Walker B motif; other site 509190005374 arginine finger; other site 509190005375 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 509190005376 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 509190005377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 509190005378 binding surface 509190005379 TPR motif; other site 509190005380 Tetratricopeptide repeat; Region: TPR_16; pfam13432 509190005381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 509190005382 binding surface 509190005383 TPR motif; other site 509190005384 TPR repeat; Region: TPR_11; pfam13414 509190005385 flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK00794 509190005386 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12794 509190005387 flagellin; Reviewed; Region: PRK12687 509190005388 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 509190005389 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 509190005390 flagellin; Reviewed; Region: PRK12687 509190005391 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 509190005392 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 509190005393 FlaG protein; Region: FlaG; cl00591 509190005394 flagellin; Reviewed; Region: PRK12687 509190005395 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 509190005396 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 509190005397 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 509190005398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 509190005399 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 509190005400 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 509190005401 dimer interface [polypeptide binding]; other site 509190005402 ssDNA binding site [nucleotide binding]; other site 509190005403 tetramer (dimer of dimers) interface [polypeptide binding]; other site 509190005404 pyruvate phosphate dikinase; Provisional; Region: PRK09279 509190005405 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 509190005406 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 509190005407 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 509190005408 Methyltransferase domain; Region: Methyltransf_23; pfam13489 509190005409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190005410 S-adenosylmethionine binding site [chemical binding]; other site 509190005411 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 509190005412 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 509190005413 Pirin-related protein [General function prediction only]; Region: COG1741 509190005414 Pirin; Region: Pirin; pfam02678 509190005415 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509190005416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190005417 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 509190005418 putative effector binding pocket; other site 509190005419 dimerization interface [polypeptide binding]; other site 509190005420 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 509190005421 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 509190005422 nucleotide binding site [chemical binding]; other site 509190005423 putative NEF/HSP70 interaction site [polypeptide binding]; other site 509190005424 SBD interface [polypeptide binding]; other site 509190005425 Predicted flavoproteins [General function prediction only]; Region: COG2081 509190005426 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 509190005427 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 509190005428 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 509190005429 ATP binding site [chemical binding]; other site 509190005430 putative Mg++ binding site [ion binding]; other site 509190005431 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509190005432 nucleotide binding region [chemical binding]; other site 509190005433 ATP-binding site [chemical binding]; other site 509190005434 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 509190005435 RNA binding site [nucleotide binding]; other site 509190005436 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 509190005437 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 509190005438 CTP synthetase; Validated; Region: pyrG; PRK05380 509190005439 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 509190005440 Catalytic site [active] 509190005441 active site 509190005442 UTP binding site [chemical binding]; other site 509190005443 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 509190005444 active site 509190005445 putative oxyanion hole; other site 509190005446 catalytic triad [active] 509190005447 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 509190005448 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 509190005449 catalytic motif [active] 509190005450 Catalytic residue [active] 509190005451 enoyl-CoA hydratase; Provisional; Region: PRK06190 509190005452 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509190005453 substrate binding site [chemical binding]; other site 509190005454 oxyanion hole (OAH) forming residues; other site 509190005455 trimer interface [polypeptide binding]; other site 509190005456 enolase; Provisional; Region: eno; PRK00077 509190005457 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 509190005458 dimer interface [polypeptide binding]; other site 509190005459 metal binding site [ion binding]; metal-binding site 509190005460 substrate binding pocket [chemical binding]; other site 509190005461 Septum formation initiator; Region: DivIC; pfam04977 509190005462 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 509190005463 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 509190005464 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 509190005465 tetramer interface [polypeptide binding]; other site 509190005466 TPP-binding site [chemical binding]; other site 509190005467 heterodimer interface [polypeptide binding]; other site 509190005468 phosphorylation loop region [posttranslational modification] 509190005469 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 509190005470 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 509190005471 E3 interaction surface; other site 509190005472 lipoyl attachment site [posttranslational modification]; other site 509190005473 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 509190005474 alpha subunit interface [polypeptide binding]; other site 509190005475 TPP binding site [chemical binding]; other site 509190005476 heterodimer interface [polypeptide binding]; other site 509190005477 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 509190005478 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 509190005479 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 509190005480 E3 interaction surface; other site 509190005481 lipoyl attachment site [posttranslational modification]; other site 509190005482 e3 binding domain; Region: E3_binding; pfam02817 509190005483 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 509190005484 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 509190005485 catalytic residues [active] 509190005486 dimer interface [polypeptide binding]; other site 509190005487 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 509190005488 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 509190005489 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509190005490 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 509190005491 Predicted membrane protein [Function unknown]; Region: COG2259 509190005492 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 509190005493 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 509190005494 acyl-activating enzyme (AAE) consensus motif; other site 509190005495 putative AMP binding site [chemical binding]; other site 509190005496 lipoyl synthase; Provisional; Region: PRK05481 509190005497 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509190005498 FeS/SAM binding site; other site 509190005499 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 509190005500 putative coenzyme Q binding site [chemical binding]; other site 509190005501 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 509190005502 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 509190005503 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 509190005504 substrate binding site; other site 509190005505 dimer interface; other site 509190005506 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 509190005507 homotrimer interaction site [polypeptide binding]; other site 509190005508 zinc binding site [ion binding]; other site 509190005509 CDP-binding sites; other site 509190005510 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 509190005511 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 509190005512 FMN binding site [chemical binding]; other site 509190005513 active site 509190005514 catalytic residues [active] 509190005515 substrate binding site [chemical binding]; other site 509190005516 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 509190005517 PAS domain; Region: PAS; smart00091 509190005518 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190005519 dimer interface [polypeptide binding]; other site 509190005520 phosphorylation site [posttranslational modification] 509190005521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190005522 ATP binding site [chemical binding]; other site 509190005523 Mg2+ binding site [ion binding]; other site 509190005524 G-X-G motif; other site 509190005525 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 509190005526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190005527 active site 509190005528 phosphorylation site [posttranslational modification] 509190005529 intermolecular recognition site; other site 509190005530 dimerization interface [polypeptide binding]; other site 509190005531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509190005532 Walker A motif; other site 509190005533 ATP binding site [chemical binding]; other site 509190005534 Walker B motif; other site 509190005535 arginine finger; other site 509190005536 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 509190005537 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 509190005538 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 509190005539 dimerization interface [polypeptide binding]; other site 509190005540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190005541 dimer interface [polypeptide binding]; other site 509190005542 phosphorylation site [posttranslational modification] 509190005543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190005544 ATP binding site [chemical binding]; other site 509190005545 Mg2+ binding site [ion binding]; other site 509190005546 G-X-G motif; other site 509190005547 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 509190005548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190005549 active site 509190005550 phosphorylation site [posttranslational modification] 509190005551 intermolecular recognition site; other site 509190005552 dimerization interface [polypeptide binding]; other site 509190005553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509190005554 Walker A motif; other site 509190005555 ATP binding site [chemical binding]; other site 509190005556 Walker B motif; other site 509190005557 arginine finger; other site 509190005558 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 509190005559 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 509190005560 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 509190005561 homodimer interface [polypeptide binding]; other site 509190005562 substrate-cofactor binding pocket; other site 509190005563 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190005564 catalytic residue [active] 509190005565 bacterial Hfq-like; Region: Hfq; cd01716 509190005566 hexamer interface [polypeptide binding]; other site 509190005567 Sm1 motif; other site 509190005568 RNA binding site [nucleotide binding]; other site 509190005569 Sm2 motif; other site 509190005570 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 509190005571 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 509190005572 HflX GTPase family; Region: HflX; cd01878 509190005573 G1 box; other site 509190005574 GTP/Mg2+ binding site [chemical binding]; other site 509190005575 Switch I region; other site 509190005576 G2 box; other site 509190005577 G3 box; other site 509190005578 Switch II region; other site 509190005579 G4 box; other site 509190005580 G5 box; other site 509190005581 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 509190005582 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 509190005583 homodimer interface [polypeptide binding]; other site 509190005584 metal binding site [ion binding]; metal-binding site 509190005585 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 509190005586 homodimer interface [polypeptide binding]; other site 509190005587 active site 509190005588 putative chemical substrate binding site [chemical binding]; other site 509190005589 metal binding site [ion binding]; metal-binding site 509190005590 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 509190005591 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 509190005592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190005593 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 509190005594 homotrimer interface [polypeptide binding]; other site 509190005595 Walker A motif; other site 509190005596 GTP binding site [chemical binding]; other site 509190005597 Walker B motif; other site 509190005598 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 509190005599 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190005600 N-terminal plug; other site 509190005601 ligand-binding site [chemical binding]; other site 509190005602 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 509190005603 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 509190005604 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 509190005605 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509190005606 catalytic residue [active] 509190005607 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 509190005608 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 509190005609 intersubunit interface [polypeptide binding]; other site 509190005610 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 509190005611 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 509190005612 ABC-ATPase subunit interface; other site 509190005613 dimer interface [polypeptide binding]; other site 509190005614 putative PBP binding regions; other site 509190005615 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 509190005616 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 509190005617 Walker A/P-loop; other site 509190005618 ATP binding site [chemical binding]; other site 509190005619 Q-loop/lid; other site 509190005620 ABC transporter signature motif; other site 509190005621 Walker B; other site 509190005622 D-loop; other site 509190005623 H-loop/switch region; other site 509190005624 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 509190005625 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 509190005626 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 509190005627 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 509190005628 catalytic triad [active] 509190005629 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 509190005630 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 509190005631 putative dimer interface [polypeptide binding]; other site 509190005632 active site pocket [active] 509190005633 putative cataytic base [active] 509190005634 cobalamin synthase; Reviewed; Region: cobS; PRK00235 509190005635 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 509190005636 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 509190005637 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 509190005638 Domain of unknown function (DUF303); Region: DUF303; pfam03629 509190005639 Domain of unknown function (DUF303); Region: DUF303; pfam03629 509190005640 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 509190005641 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 509190005642 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 509190005643 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 509190005644 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 509190005645 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190005646 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190005647 SapC; Region: SapC; pfam07277 509190005648 Cupin-like domain; Region: Cupin_8; pfam13621 509190005649 alpha-galactosidase; Region: PLN02808; cl17638 509190005650 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 509190005651 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 509190005652 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 509190005653 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 509190005654 active site 509190005655 Transcriptional regulators [Transcription]; Region: FadR; COG2186 509190005656 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509190005657 DNA-binding site [nucleotide binding]; DNA binding site 509190005658 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 509190005659 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 509190005660 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 509190005661 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190005662 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190005663 Transcriptional regulators [Transcription]; Region: PurR; COG1609 509190005664 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 509190005665 DNA binding site [nucleotide binding] 509190005666 domain linker motif; other site 509190005667 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 509190005668 putative dimerization interface [polypeptide binding]; other site 509190005669 putative ligand binding site [chemical binding]; other site 509190005670 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 509190005671 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 509190005672 active site 509190005673 non-prolyl cis peptide bond; other site 509190005674 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 509190005675 putative catalytic residues [active] 509190005676 Ferredoxin [Energy production and conversion]; Region: COG1146 509190005677 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 509190005678 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 509190005679 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 509190005680 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 509190005681 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 509190005682 membrane-bound complex binding site; other site 509190005683 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190005684 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190005685 N-terminal plug; other site 509190005686 ligand-binding site [chemical binding]; other site 509190005687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 509190005688 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 509190005689 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190005690 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509190005691 dimerization interface [polypeptide binding]; other site 509190005692 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 509190005693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509190005694 dimer interface [polypeptide binding]; other site 509190005695 conserved gate region; other site 509190005696 putative PBP binding loops; other site 509190005697 ABC-ATPase subunit interface; other site 509190005698 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 509190005699 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 509190005700 Walker A/P-loop; other site 509190005701 ATP binding site [chemical binding]; other site 509190005702 Q-loop/lid; other site 509190005703 ABC transporter signature motif; other site 509190005704 Walker B; other site 509190005705 D-loop; other site 509190005706 H-loop/switch region; other site 509190005707 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509190005708 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 509190005709 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 509190005710 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_15; cd12180 509190005711 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 509190005712 putative ligand binding site [chemical binding]; other site 509190005713 putative NAD binding site [chemical binding]; other site 509190005714 catalytic site [active] 509190005715 hypothetical protein; Provisional; Region: PRK06208 509190005716 intersubunit interface [polypeptide binding]; other site 509190005717 active site 509190005718 Zn2+ binding site [ion binding]; other site 509190005719 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 509190005720 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 509190005721 membrane-bound complex binding site; other site 509190005722 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190005723 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190005724 N-terminal plug; other site 509190005725 ligand-binding site [chemical binding]; other site 509190005726 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 509190005727 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 509190005728 active site residue [active] 509190005729 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 509190005730 active site residue [active] 509190005731 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 509190005732 active site residue [active] 509190005733 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 509190005734 active site residue [active] 509190005735 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509190005736 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 509190005737 C-terminal domain interface [polypeptide binding]; other site 509190005738 GSH binding site (G-site) [chemical binding]; other site 509190005739 dimer interface [polypeptide binding]; other site 509190005740 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 509190005741 dimer interface [polypeptide binding]; other site 509190005742 substrate binding pocket (H-site) [chemical binding]; other site 509190005743 N-terminal domain interface [polypeptide binding]; other site 509190005744 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 509190005745 active site 509190005746 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 509190005747 dimer interface [polypeptide binding]; other site 509190005748 non-prolyl cis peptide bond; other site 509190005749 insertion regions; other site 509190005750 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 509190005751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190005752 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 509190005753 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190005754 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190005755 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 509190005756 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 509190005757 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 509190005758 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509190005759 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190005760 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 509190005761 putative effector binding pocket; other site 509190005762 dimerization interface [polypeptide binding]; other site 509190005763 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 509190005764 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 509190005765 NAD(P) binding site [chemical binding]; other site 509190005766 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 509190005767 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 509190005768 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190005769 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190005770 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 509190005771 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 509190005772 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 509190005773 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 509190005774 active site 509190005775 SAM binding site [chemical binding]; other site 509190005776 homodimer interface [polypeptide binding]; other site 509190005777 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 509190005778 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 509190005779 molybdopterin cofactor binding site; other site 509190005780 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 509190005781 molybdopterin cofactor binding site; other site 509190005782 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 509190005783 [2Fe-2S] cluster binding site [ion binding]; other site 509190005784 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 509190005785 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509190005786 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 509190005787 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 509190005788 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 509190005789 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 509190005790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190005791 putative substrate translocation pore; other site 509190005792 NMT1-like family; Region: NMT1_2; pfam13379 509190005793 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 509190005794 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 509190005795 ANTAR domain; Region: ANTAR; pfam03861 509190005796 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 509190005797 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 509190005798 Walker A/P-loop; other site 509190005799 ATP binding site [chemical binding]; other site 509190005800 Q-loop/lid; other site 509190005801 ABC transporter signature motif; other site 509190005802 Walker B; other site 509190005803 D-loop; other site 509190005804 H-loop/switch region; other site 509190005805 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 509190005806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509190005807 dimer interface [polypeptide binding]; other site 509190005808 conserved gate region; other site 509190005809 putative PBP binding loops; other site 509190005810 ABC-ATPase subunit interface; other site 509190005811 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 509190005812 NMT1-like family; Region: NMT1_2; pfam13379 509190005813 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 509190005814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190005815 active site 509190005816 phosphorylation site [posttranslational modification] 509190005817 intermolecular recognition site; other site 509190005818 dimerization interface [polypeptide binding]; other site 509190005819 LytTr DNA-binding domain; Region: LytTR; smart00850 509190005820 Histidine kinase; Region: His_kinase; pfam06580 509190005821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190005822 ATP binding site [chemical binding]; other site 509190005823 Mg2+ binding site [ion binding]; other site 509190005824 G-X-G motif; other site 509190005825 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 509190005826 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 509190005827 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 509190005828 PGAP1-like protein; Region: PGAP1; pfam07819 509190005829 TAP-like protein; Region: Abhydrolase_4; pfam08386 509190005830 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509190005831 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190005832 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190005833 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509190005834 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 509190005835 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 509190005836 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 509190005837 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509190005838 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 509190005839 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190005840 putative active site [active] 509190005841 heme pocket [chemical binding]; other site 509190005842 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190005843 putative active site [active] 509190005844 heme pocket [chemical binding]; other site 509190005845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190005846 dimer interface [polypeptide binding]; other site 509190005847 phosphorylation site [posttranslational modification] 509190005848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190005849 ATP binding site [chemical binding]; other site 509190005850 Mg2+ binding site [ion binding]; other site 509190005851 G-X-G motif; other site 509190005852 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 509190005853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190005854 active site 509190005855 phosphorylation site [posttranslational modification] 509190005856 intermolecular recognition site; other site 509190005857 dimerization interface [polypeptide binding]; other site 509190005858 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 509190005859 DNA binding residues [nucleotide binding] 509190005860 dimerization interface [polypeptide binding]; other site 509190005861 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 509190005862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190005863 active site 509190005864 phosphorylation site [posttranslational modification] 509190005865 intermolecular recognition site; other site 509190005866 dimerization interface [polypeptide binding]; other site 509190005867 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 509190005868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190005869 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 509190005870 Isochorismatase family; Region: Isochorismatase; pfam00857 509190005871 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 509190005872 catalytic triad [active] 509190005873 conserved cis-peptide bond; other site 509190005874 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 509190005875 homotrimer interaction site [polypeptide binding]; other site 509190005876 putative active site [active] 509190005877 pyrimidine utilization protein D; Region: RutD; TIGR03611 509190005878 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 509190005879 pyrimidine utilization protein A; Region: RutA; TIGR03612 509190005880 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 509190005881 active site 509190005882 dimer interface [polypeptide binding]; other site 509190005883 non-prolyl cis peptide bond; other site 509190005884 insertion regions; other site 509190005885 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 509190005886 active site 509190005887 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 509190005888 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190005889 Purine nucleoside permease (NUP); Region: NUP; cl17832 509190005890 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 509190005891 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 509190005892 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 509190005893 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 509190005894 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 509190005895 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 509190005896 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 509190005897 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 509190005898 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 509190005899 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 509190005900 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 509190005901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190005902 NAD(P) binding site [chemical binding]; other site 509190005903 active site 509190005904 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 509190005905 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 509190005906 putative active site [active] 509190005907 putative metal binding site [ion binding]; other site 509190005908 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 509190005909 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190005910 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190005911 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190005912 Predicted acyl esterases [General function prediction only]; Region: COG2936 509190005913 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 509190005914 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 509190005915 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190005916 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 509190005917 putative dimerization interface [polypeptide binding]; other site 509190005918 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 509190005919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190005920 active site 509190005921 phosphorylation site [posttranslational modification] 509190005922 intermolecular recognition site; other site 509190005923 dimerization interface [polypeptide binding]; other site 509190005924 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 509190005925 DNA binding residues [nucleotide binding] 509190005926 dimerization interface [polypeptide binding]; other site 509190005927 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 509190005928 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 509190005929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190005930 ATP binding site [chemical binding]; other site 509190005931 Mg2+ binding site [ion binding]; other site 509190005932 G-X-G motif; other site 509190005933 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 509190005934 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 509190005935 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509190005936 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 509190005937 catalytic triad [active] 509190005938 dimer interface [polypeptide binding]; other site 509190005939 Isochorismatase family; Region: Isochorismatase; pfam00857 509190005940 conserved cis-peptide bond; other site 509190005941 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 509190005942 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 509190005943 active site 509190005944 Predicted membrane protein [Function unknown]; Region: COG2259 509190005945 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 509190005946 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 509190005947 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 509190005948 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 509190005949 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 509190005950 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 509190005951 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 509190005952 Cytochrome c2 [Energy production and conversion]; Region: COG3474 509190005953 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 509190005954 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 509190005955 Metal-binding active site; metal-binding site 509190005956 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 509190005957 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 509190005958 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 509190005959 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 509190005960 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 509190005961 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 509190005962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190005963 putative substrate translocation pore; other site 509190005964 Transcriptional regulators [Transcription]; Region: PurR; COG1609 509190005965 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 509190005966 DNA binding site [nucleotide binding] 509190005967 domain linker motif; other site 509190005968 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 509190005969 dimerization interface [polypeptide binding]; other site 509190005970 ligand binding site [chemical binding]; other site 509190005971 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 509190005972 HlyD family secretion protein; Region: HlyD_3; pfam13437 509190005973 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 509190005974 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 509190005975 FtsX-like permease family; Region: FtsX; pfam02687 509190005976 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 509190005977 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 509190005978 Walker A/P-loop; other site 509190005979 ATP binding site [chemical binding]; other site 509190005980 Q-loop/lid; other site 509190005981 ABC transporter signature motif; other site 509190005982 Walker B; other site 509190005983 D-loop; other site 509190005984 H-loop/switch region; other site 509190005985 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 509190005986 putative hydrolase; Provisional; Region: PRK02113 509190005987 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 509190005988 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 509190005989 active site 509190005990 DNA polymerase III subunit delta'; Validated; Region: PRK07471 509190005991 DNA polymerase III subunit delta'; Validated; Region: PRK08485 509190005992 thymidylate kinase; Validated; Region: tmk; PRK00698 509190005993 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 509190005994 TMP-binding site; other site 509190005995 ATP-binding site [chemical binding]; other site 509190005996 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 509190005997 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 509190005998 Sporulation related domain; Region: SPOR; pfam05036 509190005999 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 509190006000 Methyltransferase small domain; Region: MTS; pfam05175 509190006001 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 509190006002 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509190006003 RNA binding surface [nucleotide binding]; other site 509190006004 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 509190006005 active site 509190006006 uracil binding [chemical binding]; other site 509190006007 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 509190006008 CPxP motif; other site 509190006009 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 509190006010 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 509190006011 CoA-transferase family III; Region: CoA_transf_3; pfam02515 509190006012 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 509190006013 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 509190006014 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 509190006015 catalytic residues [active] 509190006016 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 509190006017 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 509190006018 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509190006019 ATP binding site [chemical binding]; other site 509190006020 putative Mg++ binding site [ion binding]; other site 509190006021 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509190006022 nucleotide binding region [chemical binding]; other site 509190006023 ATP-binding site [chemical binding]; other site 509190006024 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 509190006025 Uncharacterized conserved protein [Function unknown]; Region: COG2938 509190006026 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 509190006027 DEAD-like helicases superfamily; Region: DEXDc; smart00487 509190006028 ATP binding site [chemical binding]; other site 509190006029 Mg++ binding site [ion binding]; other site 509190006030 motif III; other site 509190006031 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509190006032 nucleotide binding region [chemical binding]; other site 509190006033 ATP-binding site [chemical binding]; other site 509190006034 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 509190006035 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism]; Region: COG4421 509190006036 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 509190006037 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 509190006038 NAD(P) binding site [chemical binding]; other site 509190006039 catalytic residues [active] 509190006040 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 509190006041 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 509190006042 metal binding site [ion binding]; metal-binding site 509190006043 active site 509190006044 I-site; other site 509190006045 enoyl-CoA hydratase; Provisional; Region: PRK05981 509190006046 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509190006047 substrate binding site [chemical binding]; other site 509190006048 oxyanion hole (OAH) forming residues; other site 509190006049 trimer interface [polypeptide binding]; other site 509190006050 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 509190006051 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 509190006052 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 509190006053 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 509190006054 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 509190006055 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 509190006056 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 509190006057 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509190006058 catalytic residue [active] 509190006059 FeS assembly protein SufD; Region: sufD; TIGR01981 509190006060 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 509190006061 FeS assembly ATPase SufC; Region: sufC; TIGR01978 509190006062 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 509190006063 Walker A/P-loop; other site 509190006064 ATP binding site [chemical binding]; other site 509190006065 Q-loop/lid; other site 509190006066 ABC transporter signature motif; other site 509190006067 Walker B; other site 509190006068 D-loop; other site 509190006069 H-loop/switch region; other site 509190006070 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 509190006071 putative ABC transporter; Region: ycf24; CHL00085 509190006072 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 509190006073 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 509190006074 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509190006075 catalytic residue [active] 509190006076 Predicted transcriptional regulator [Transcription]; Region: COG1959 509190006077 Transcriptional regulator; Region: Rrf2; cl17282 509190006078 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 509190006079 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 509190006080 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 509190006081 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509190006082 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 509190006083 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 509190006084 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 509190006085 active site 509190006086 HIGH motif; other site 509190006087 dimer interface [polypeptide binding]; other site 509190006088 KMSKS motif; other site 509190006089 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509190006090 RNA binding surface [nucleotide binding]; other site 509190006091 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 509190006092 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 509190006093 catalytic triad [active] 509190006094 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 509190006095 Peptidase family M23; Region: Peptidase_M23; pfam01551 509190006096 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 509190006097 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 509190006098 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 509190006099 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 509190006100 Helix-turn-helix domain; Region: HTH_36; pfam13730 509190006101 peptide chain release factor 2; Validated; Region: prfB; PRK00578 509190006102 This domain is found in peptide chain release factors; Region: PCRF; smart00937 509190006103 RF-1 domain; Region: RF-1; pfam00472 509190006104 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 509190006105 Transglycosylase; Region: Transgly; pfam00912 509190006106 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 509190006107 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 509190006108 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 509190006109 active site 509190006110 metal binding site [ion binding]; metal-binding site 509190006111 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 509190006112 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 509190006113 RNA binding site [nucleotide binding]; other site 509190006114 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 509190006115 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 509190006116 Peptidase family M48; Region: Peptidase_M48; pfam01435 509190006117 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 509190006118 binding surface 509190006119 TPR motif; other site 509190006120 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 509190006121 binding surface 509190006122 TPR motif; other site 509190006123 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 509190006124 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 509190006125 catalytic residues [active] 509190006126 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 509190006127 ThiS interaction site; other site 509190006128 putative active site [active] 509190006129 tetramer interface [polypeptide binding]; other site 509190006130 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 509190006131 thiS-thiF/thiG interaction site; other site 509190006132 Dehydroquinase class II; Region: DHquinase_II; pfam01220 509190006133 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 509190006134 trimer interface [polypeptide binding]; other site 509190006135 active site 509190006136 dimer interface [polypeptide binding]; other site 509190006137 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 509190006138 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 509190006139 carboxyltransferase (CT) interaction site; other site 509190006140 biotinylation site [posttranslational modification]; other site 509190006141 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 509190006142 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 509190006143 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 509190006144 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 509190006145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 509190006146 NADH dehydrogenase; Validated; Region: PRK08183 509190006147 TSCPD domain; Region: TSCPD; pfam12637 509190006148 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 509190006149 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 509190006150 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 509190006151 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 509190006152 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 509190006153 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 509190006154 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 509190006155 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 509190006156 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 509190006157 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 509190006158 dimer interface [polypeptide binding]; other site 509190006159 anticodon binding site; other site 509190006160 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 509190006161 homodimer interface [polypeptide binding]; other site 509190006162 motif 1; other site 509190006163 active site 509190006164 motif 2; other site 509190006165 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 509190006166 active site 509190006167 motif 3; other site 509190006168 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 509190006169 triosephosphate isomerase; Provisional; Region: PRK14565 509190006170 substrate binding site [chemical binding]; other site 509190006171 dimer interface [polypeptide binding]; other site 509190006172 catalytic triad [active] 509190006173 SurA N-terminal domain; Region: SurA_N_3; cl07813 509190006174 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 509190006175 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 509190006176 anthranilate synthase component I; Provisional; Region: PRK13573 509190006177 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 509190006178 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 509190006179 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 509190006180 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 509190006181 glutamine binding [chemical binding]; other site 509190006182 catalytic triad [active] 509190006183 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 509190006184 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 509190006185 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 509190006186 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 509190006187 active site 509190006188 ribulose/triose binding site [chemical binding]; other site 509190006189 phosphate binding site [ion binding]; other site 509190006190 substrate (anthranilate) binding pocket [chemical binding]; other site 509190006191 product (indole) binding pocket [chemical binding]; other site 509190006192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190006193 S-adenosylmethionine binding site [chemical binding]; other site 509190006194 LexA repressor; Validated; Region: PRK00215 509190006195 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 509190006196 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 509190006197 Catalytic site [active] 509190006198 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 509190006199 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 509190006200 tetramer interface [polypeptide binding]; other site 509190006201 active site 509190006202 Mg2+/Mn2+ binding site [ion binding]; other site 509190006203 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 509190006204 Competence protein; Region: Competence; pfam03772 509190006205 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 509190006206 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 509190006207 active site 509190006208 HIGH motif; other site 509190006209 nucleotide binding site [chemical binding]; other site 509190006210 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 509190006211 active site 509190006212 KMSKS motif; other site 509190006213 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 509190006214 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 509190006215 dimer interface [polypeptide binding]; other site 509190006216 active site 509190006217 citrylCoA binding site [chemical binding]; other site 509190006218 NADH binding [chemical binding]; other site 509190006219 cationic pore residues; other site 509190006220 oxalacetate/citrate binding site [chemical binding]; other site 509190006221 coenzyme A binding site [chemical binding]; other site 509190006222 catalytic triad [active] 509190006223 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 509190006224 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 509190006225 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 509190006226 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 509190006227 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 509190006228 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 509190006229 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 509190006230 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 509190006231 active site 509190006232 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 509190006233 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 509190006234 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 509190006235 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 509190006236 trimer interface [polypeptide binding]; other site 509190006237 active site 509190006238 UDP-GlcNAc binding site [chemical binding]; other site 509190006239 lipid binding site [chemical binding]; lipid-binding site 509190006240 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 509190006241 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 509190006242 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 509190006243 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 509190006244 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 509190006245 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 509190006246 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 509190006247 Surface antigen; Region: Bac_surface_Ag; pfam01103 509190006248 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 509190006249 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 509190006250 active site 509190006251 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 509190006252 protein binding site [polypeptide binding]; other site 509190006253 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 509190006254 putative substrate binding region [chemical binding]; other site 509190006255 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 509190006256 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 509190006257 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 509190006258 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 509190006259 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 509190006260 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 509190006261 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 509190006262 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 509190006263 catalytic residue [active] 509190006264 putative FPP diphosphate binding site; other site 509190006265 putative FPP binding hydrophobic cleft; other site 509190006266 dimer interface [polypeptide binding]; other site 509190006267 putative IPP diphosphate binding site; other site 509190006268 ribosome recycling factor; Reviewed; Region: frr; PRK00083 509190006269 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 509190006270 hinge region; other site 509190006271 elongation factor Ts; Provisional; Region: tsf; PRK09377 509190006272 UBA/TS-N domain; Region: UBA; pfam00627 509190006273 Elongation factor TS; Region: EF_TS; pfam00889 509190006274 Elongation factor TS; Region: EF_TS; pfam00889 509190006275 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 509190006276 rRNA interaction site [nucleotide binding]; other site 509190006277 S8 interaction site; other site 509190006278 putative laminin-1 binding site; other site 509190006279 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 509190006280 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 509190006281 Methyltransferase domain; Region: Methyltransf_23; pfam13489 509190006282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190006283 S-adenosylmethionine binding site [chemical binding]; other site 509190006284 Uncharacterized conserved protein [Function unknown]; Region: COG3791 509190006285 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 509190006286 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 509190006287 putative active site [active] 509190006288 putative PHP Thumb interface [polypeptide binding]; other site 509190006289 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 509190006290 generic binding surface II; other site 509190006291 generic binding surface I; other site 509190006292 nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring nucleoside hydrolase from Caenorhabditis elegans. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_CeIAG; cd02649 509190006293 active site 509190006294 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 509190006295 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 509190006296 Walker A/P-loop; other site 509190006297 ATP binding site [chemical binding]; other site 509190006298 Q-loop/lid; other site 509190006299 ABC transporter signature motif; other site 509190006300 Walker B; other site 509190006301 D-loop; other site 509190006302 H-loop/switch region; other site 509190006303 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 509190006304 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 509190006305 FtsX-like permease family; Region: FtsX; pfam02687 509190006306 prolyl-tRNA synthetase; Provisional; Region: PRK12325 509190006307 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 509190006308 dimer interface [polypeptide binding]; other site 509190006309 motif 1; other site 509190006310 active site 509190006311 motif 2; other site 509190006312 motif 3; other site 509190006313 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 509190006314 anticodon binding site; other site 509190006315 Protein of unknown function (DUF1467); Region: DUF1467; cl11569 509190006316 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 509190006317 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 509190006318 dimer interface [polypeptide binding]; other site 509190006319 substrate binding site [chemical binding]; other site 509190006320 metal binding site [ion binding]; metal-binding site 509190006321 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 509190006322 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 509190006323 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 509190006324 pantothenate kinase; Reviewed; Region: PRK13318 509190006325 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 509190006326 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 509190006327 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 509190006328 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 509190006329 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 509190006330 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 509190006331 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 509190006332 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 509190006333 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 509190006334 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 509190006335 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 509190006336 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 509190006337 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 509190006338 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 509190006339 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 509190006340 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 509190006341 4Fe-4S binding domain; Region: Fer4; pfam00037 509190006342 4Fe-4S binding domain; Region: Fer4; pfam00037 509190006343 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 509190006344 NADH dehydrogenase subunit G; Validated; Region: PRK09130 509190006345 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 509190006346 catalytic loop [active] 509190006347 iron binding site [ion binding]; other site 509190006348 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 509190006349 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 509190006350 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 509190006351 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 509190006352 SLBB domain; Region: SLBB; pfam10531 509190006353 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 509190006354 NADH dehydrogenase subunit E; Validated; Region: PRK07539 509190006355 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 509190006356 putative dimer interface [polypeptide binding]; other site 509190006357 [2Fe-2S] cluster binding site [ion binding]; other site 509190006358 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 509190006359 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 509190006360 NADH dehydrogenase subunit D; Validated; Region: PRK06075 509190006361 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 509190006362 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 509190006363 NADH dehydrogenase subunit B; Validated; Region: PRK06411 509190006364 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 509190006365 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 509190006366 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 509190006367 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 509190006368 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 509190006369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 509190006370 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 509190006371 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 509190006372 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 509190006373 IHF - DNA interface [nucleotide binding]; other site 509190006374 IHF dimer interface [polypeptide binding]; other site 509190006375 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 509190006376 Found in ATP-dependent protease La (LON); Region: LON; smart00464 509190006377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509190006378 Walker A motif; other site 509190006379 ATP binding site [chemical binding]; other site 509190006380 Walker B motif; other site 509190006381 arginine finger; other site 509190006382 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 509190006383 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 509190006384 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 509190006385 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 509190006386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509190006387 Walker A motif; other site 509190006388 ATP binding site [chemical binding]; other site 509190006389 Walker B motif; other site 509190006390 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 509190006391 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 509190006392 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 509190006393 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 509190006394 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 509190006395 oligomer interface [polypeptide binding]; other site 509190006396 active site residues [active] 509190006397 trigger factor; Provisional; Region: tig; PRK01490 509190006398 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 509190006399 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 509190006400 Uncharacterized conserved protein [Function unknown]; Region: COG0062 509190006401 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 509190006402 putative substrate binding site [chemical binding]; other site 509190006403 putative ATP binding site [chemical binding]; other site 509190006404 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 509190006405 catalytic core [active] 509190006406 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 509190006407 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 509190006408 active site 509190006409 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 509190006410 Nitrogen regulatory protein P-II; Region: P-II; smart00938 509190006411 glutamine synthetase; Provisional; Region: glnA; PRK09469 509190006412 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 509190006413 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 509190006414 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 509190006415 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190006416 N-terminal plug; other site 509190006417 ligand-binding site [chemical binding]; other site 509190006418 Uncharacterized conserved protein [Function unknown]; Region: COG1359 509190006419 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 509190006420 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 509190006421 active site 509190006422 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 509190006423 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 509190006424 active site 509190006425 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 509190006426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190006427 ATP binding site [chemical binding]; other site 509190006428 Mg2+ binding site [ion binding]; other site 509190006429 G-X-G motif; other site 509190006430 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 509190006431 anchoring element; other site 509190006432 dimer interface [polypeptide binding]; other site 509190006433 ATP binding site [chemical binding]; other site 509190006434 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 509190006435 active site 509190006436 putative metal-binding site [ion binding]; other site 509190006437 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 509190006438 EcsC protein family; Region: EcsC; pfam12787 509190006439 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 509190006440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 509190006441 polyphosphate kinase; Provisional; Region: PRK05443 509190006442 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 509190006443 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 509190006444 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 509190006445 putative domain interface [polypeptide binding]; other site 509190006446 putative active site [active] 509190006447 catalytic site [active] 509190006448 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 509190006449 putative domain interface [polypeptide binding]; other site 509190006450 putative active site [active] 509190006451 catalytic site [active] 509190006452 Phosphotransferase enzyme family; Region: APH; pfam01636 509190006453 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 509190006454 active site 509190006455 substrate binding site [chemical binding]; other site 509190006456 ATP binding site [chemical binding]; other site 509190006457 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 509190006458 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 509190006459 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509190006460 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190006461 dimer interface [polypeptide binding]; other site 509190006462 phosphorylation site [posttranslational modification] 509190006463 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190006464 ATP binding site [chemical binding]; other site 509190006465 Mg2+ binding site [ion binding]; other site 509190006466 G-X-G motif; other site 509190006467 Response regulator receiver domain; Region: Response_reg; pfam00072 509190006468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190006469 active site 509190006470 phosphorylation site [posttranslational modification] 509190006471 intermolecular recognition site; other site 509190006472 dimerization interface [polypeptide binding]; other site 509190006473 ribonuclease D; Region: rnd; TIGR01388 509190006474 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 509190006475 catalytic site [active] 509190006476 putative active site [active] 509190006477 putative substrate binding site [chemical binding]; other site 509190006478 HRDC domain; Region: HRDC; pfam00570 509190006479 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 509190006480 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 509190006481 dimerization interface [polypeptide binding]; other site 509190006482 putative ATP binding site [chemical binding]; other site 509190006483 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 509190006484 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 509190006485 active site 509190006486 substrate binding site [chemical binding]; other site 509190006487 cosubstrate binding site; other site 509190006488 catalytic site [active] 509190006489 PRC-barrel domain; Region: PRC; pfam05239 509190006490 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 509190006491 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 509190006492 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 509190006493 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 509190006494 active site 509190006495 multimer interface [polypeptide binding]; other site 509190006496 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 509190006497 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 509190006498 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 509190006499 ABC transporter; Region: ABC_tran_2; pfam12848 509190006500 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 509190006501 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 509190006502 Cytochrome c553 [Energy production and conversion]; Region: COG2863 509190006503 Cytochrome c; Region: Cytochrom_C; cl11414 509190006504 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 509190006505 Low-spin heme binding site [chemical binding]; other site 509190006506 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 509190006507 D-pathway; other site 509190006508 Putative water exit pathway; other site 509190006509 Binuclear center (active site) [active] 509190006510 K-pathway; other site 509190006511 Putative proton exit pathway; other site 509190006512 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 509190006513 Peroxisomal membrane anchor protein (Pex14p) conserved region; Region: Pex14_N; pfam04695 509190006514 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 509190006515 Cytochrome c; Region: Cytochrom_C; pfam00034 509190006516 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 509190006517 DNA polymerase III subunit chi; Validated; Region: PRK05728 509190006518 multifunctional aminopeptidase A; Provisional; Region: PRK00913 509190006519 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 509190006520 interface (dimer of trimers) [polypeptide binding]; other site 509190006521 Substrate-binding/catalytic site; other site 509190006522 Zn-binding sites [ion binding]; other site 509190006523 Predicted permeases [General function prediction only]; Region: COG0795 509190006524 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 509190006525 Predicted permeases [General function prediction only]; Region: COG0795 509190006526 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 509190006527 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 509190006528 Organic solvent tolerance protein; Region: OstA_C; pfam04453 509190006529 SurA N-terminal domain; Region: SurA_N; pfam09312 509190006530 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 509190006531 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 509190006532 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 509190006533 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 509190006534 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 509190006535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190006536 S-adenosylmethionine binding site [chemical binding]; other site 509190006537 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 509190006538 HWE histidine kinase; Region: HWE_HK; pfam07536 509190006539 Predicted membrane protein [Function unknown]; Region: COG2261 509190006540 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 509190006541 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 509190006542 catalytic site [active] 509190006543 G-X2-G-X-G-K; other site 509190006544 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 509190006545 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 509190006546 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 509190006547 YceG-like family; Region: YceG; pfam02618 509190006548 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 509190006549 dimerization interface [polypeptide binding]; other site 509190006550 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 509190006551 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 509190006552 dimer interface [polypeptide binding]; other site 509190006553 active site 509190006554 acyl carrier protein; Provisional; Region: acpP; PRK00982 509190006555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190006556 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 509190006557 NAD(P) binding site [chemical binding]; other site 509190006558 active site 509190006559 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 509190006560 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 509190006561 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 509190006562 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 509190006563 catalytic triad [active] 509190006564 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 509190006565 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 509190006566 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 509190006567 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 509190006568 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 509190006569 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 509190006570 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 509190006571 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190006572 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190006573 N-terminal plug; other site 509190006574 ligand-binding site [chemical binding]; other site 509190006575 replicative DNA helicase; Provisional; Region: PRK09165 509190006576 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 509190006577 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 509190006578 Walker A motif; other site 509190006579 ATP binding site [chemical binding]; other site 509190006580 Walker B motif; other site 509190006581 DNA binding loops [nucleotide binding] 509190006582 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 509190006583 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 509190006584 active site 509190006585 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 509190006586 dimer interface [polypeptide binding]; other site 509190006587 substrate binding site [chemical binding]; other site 509190006588 catalytic residues [active] 509190006589 DNA repair protein RadA; Provisional; Region: PRK11823 509190006590 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 509190006591 Walker A motif/ATP binding site; other site 509190006592 ATP binding site [chemical binding]; other site 509190006593 Walker B motif; other site 509190006594 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 509190006595 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 509190006596 Colicin V production protein; Region: Colicin_V; pfam02674 509190006597 amidophosphoribosyltransferase; Provisional; Region: PRK09123 509190006598 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 509190006599 active site 509190006600 tetramer interface [polypeptide binding]; other site 509190006601 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 509190006602 active site 509190006603 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 509190006604 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 509190006605 short chain dehydrogenase; Provisional; Region: PRK08703 509190006606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190006607 NAD(P) binding site [chemical binding]; other site 509190006608 active site 509190006609 GTP-binding protein Der; Reviewed; Region: PRK00093 509190006610 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 509190006611 G1 box; other site 509190006612 GTP/Mg2+ binding site [chemical binding]; other site 509190006613 Switch I region; other site 509190006614 G2 box; other site 509190006615 Switch II region; other site 509190006616 G3 box; other site 509190006617 G4 box; other site 509190006618 G5 box; other site 509190006619 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 509190006620 G1 box; other site 509190006621 GTP/Mg2+ binding site [chemical binding]; other site 509190006622 Switch I region; other site 509190006623 G2 box; other site 509190006624 G3 box; other site 509190006625 Switch II region; other site 509190006626 G4 box; other site 509190006627 G5 box; other site 509190006628 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 509190006629 PQQ-like domain; Region: PQQ_2; pfam13360 509190006630 Trp docking motif [polypeptide binding]; other site 509190006631 active site 509190006632 PQQ-like domain; Region: PQQ_2; pfam13360 509190006633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 509190006634 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 509190006635 oligomerization interface [polypeptide binding]; other site 509190006636 active site 509190006637 metal binding site [ion binding]; metal-binding site 509190006638 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 509190006639 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509190006640 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509190006641 DNA binding residues [nucleotide binding] 509190006642 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 509190006643 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509190006644 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509190006645 DNA binding residues [nucleotide binding] 509190006646 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 509190006647 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 509190006648 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 509190006649 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509190006650 motif II; other site 509190006651 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 509190006652 ArsC family; Region: ArsC; pfam03960 509190006653 putative catalytic residues [active] 509190006654 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 509190006655 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 509190006656 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 509190006657 Phytase; Region: Phytase; cl17685 509190006658 Phytase; Region: Phytase; cl17685 509190006659 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 509190006660 MarR family; Region: MarR_2; pfam12802 509190006661 Transcriptional regulators [Transcription]; Region: FadR; COG2186 509190006662 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509190006663 DNA-binding site [nucleotide binding]; DNA binding site 509190006664 FCD domain; Region: FCD; pfam07729 509190006665 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 509190006666 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 509190006667 iron-sulfur cluster [ion binding]; other site 509190006668 [2Fe-2S] cluster binding site [ion binding]; other site 509190006669 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 509190006670 alpha subunit interface [polypeptide binding]; other site 509190006671 active site 509190006672 substrate binding site [chemical binding]; other site 509190006673 Fe binding site [ion binding]; other site 509190006674 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 509190006675 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 509190006676 FMN-binding pocket [chemical binding]; other site 509190006677 flavin binding motif; other site 509190006678 phosphate binding motif [ion binding]; other site 509190006679 beta-alpha-beta structure motif; other site 509190006680 NAD binding pocket [chemical binding]; other site 509190006681 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 509190006682 catalytic loop [active] 509190006683 iron binding site [ion binding]; other site 509190006684 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 509190006685 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 509190006686 acyl-CoA synthetase; Validated; Region: PRK09088 509190006687 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 509190006688 acyl-activating enzyme (AAE) consensus motif; other site 509190006689 putative AMP binding site [chemical binding]; other site 509190006690 putative active site [active] 509190006691 putative CoA binding site [chemical binding]; other site 509190006692 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 509190006693 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509190006694 substrate binding site [chemical binding]; other site 509190006695 oxyanion hole (OAH) forming residues; other site 509190006696 trimer interface [polypeptide binding]; other site 509190006697 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 509190006698 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 509190006699 NAD(P) binding site [chemical binding]; other site 509190006700 catalytic residues [active] 509190006701 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 509190006702 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190006703 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 509190006704 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 509190006705 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 509190006706 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 509190006707 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 509190006708 heterodimer interface [polypeptide binding]; other site 509190006709 multimer interface [polypeptide binding]; other site 509190006710 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 509190006711 active site 509190006712 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 509190006713 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 509190006714 heterodimer interface [polypeptide binding]; other site 509190006715 active site 509190006716 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 509190006717 tetramer interface [polypeptide binding]; other site 509190006718 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 509190006719 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 509190006720 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 509190006721 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 509190006722 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 509190006723 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 509190006724 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 509190006725 formyl-coenzyme A transferase; Provisional; Region: PRK05398 509190006726 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 509190006727 CoA-transferase family III; Region: CoA_transf_3; pfam02515 509190006728 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190006729 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190006730 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190006731 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 509190006732 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509190006733 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 509190006734 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 509190006735 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 509190006736 putative active site [active] 509190006737 putative metal binding site [ion binding]; other site 509190006738 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 509190006739 MarR family; Region: MarR_2; pfam12802 509190006740 MarR family; Region: MarR_2; cl17246 509190006741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190006742 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509190006743 putative substrate translocation pore; other site 509190006744 MarR family; Region: MarR_2; pfam12802 509190006745 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 509190006746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190006747 putative substrate translocation pore; other site 509190006748 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190006749 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190006750 N-terminal plug; other site 509190006751 ligand-binding site [chemical binding]; other site 509190006752 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 509190006753 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 509190006754 dimer interface [polypeptide binding]; other site 509190006755 active site 509190006756 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190006757 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 509190006758 NAD(P) binding site [chemical binding]; other site 509190006759 active site 509190006760 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190006761 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190006762 putative acyl-CoA synthetase; Provisional; Region: PRK06018 509190006763 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 509190006764 acyl-activating enzyme (AAE) consensus motif; other site 509190006765 AMP binding site [chemical binding]; other site 509190006766 active site 509190006767 CoA binding site [chemical binding]; other site 509190006768 Carboxylesterase family; Region: COesterase; pfam00135 509190006769 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 509190006770 substrate binding pocket [chemical binding]; other site 509190006771 catalytic triad [active] 509190006772 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190006773 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190006774 N-terminal plug; other site 509190006775 ligand-binding site [chemical binding]; other site 509190006776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190006777 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509190006778 putative substrate translocation pore; other site 509190006779 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190006780 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190006781 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 509190006782 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190006783 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190006784 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190006785 PAS domain; Region: PAS_9; pfam13426 509190006786 putative active site [active] 509190006787 heme pocket [chemical binding]; other site 509190006788 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 509190006789 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190006790 dimer interface [polypeptide binding]; other site 509190006791 putative CheW interface [polypeptide binding]; other site 509190006792 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 509190006793 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 509190006794 Transcriptional regulators [Transcription]; Region: PurR; COG1609 509190006795 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 509190006796 DNA binding site [nucleotide binding] 509190006797 domain linker motif; other site 509190006798 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 509190006799 ligand binding site [chemical binding]; other site 509190006800 dimerization interface [polypeptide binding]; other site 509190006801 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190006802 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190006803 N-terminal plug; other site 509190006804 ligand-binding site [chemical binding]; other site 509190006805 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 509190006806 phosphate binding site [ion binding]; other site 509190006807 Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Region: URH1; COG1957 509190006808 active site 509190006809 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 509190006810 HlyD family secretion protein; Region: HlyD_3; pfam13437 509190006811 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 509190006812 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190006813 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 509190006814 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190006815 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 509190006816 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 509190006817 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 509190006818 short chain dehydrogenase; Provisional; Region: PRK06523 509190006819 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190006820 NAD(P) binding site [chemical binding]; other site 509190006821 active site 509190006822 SnoaL-like domain; Region: SnoaL_2; pfam12680 509190006823 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509190006824 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190006825 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 509190006826 putative effector binding pocket; other site 509190006827 putative dimerization interface [polypeptide binding]; other site 509190006828 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 509190006829 ArsC family; Region: ArsC; pfam03960 509190006830 catalytic residues [active] 509190006831 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 509190006832 arsenical-resistance protein; Region: acr3; TIGR00832 509190006833 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 509190006834 Low molecular weight phosphatase family; Region: LMWPc; cd00115 509190006835 active site 509190006836 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509190006837 dimerization interface [polypeptide binding]; other site 509190006838 putative DNA binding site [nucleotide binding]; other site 509190006839 putative Zn2+ binding site [ion binding]; other site 509190006840 Uncharacterized conserved protein [Function unknown]; Region: COG1359 509190006841 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 509190006842 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 509190006843 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 509190006844 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 509190006845 active site 509190006846 catalytic tetrad [active] 509190006847 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509190006848 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 509190006849 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 509190006850 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 509190006851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190006852 putative substrate translocation pore; other site 509190006853 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509190006854 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509190006855 DNA binding site [nucleotide binding] 509190006856 Predicted ATPase [General function prediction only]; Region: COG3903 509190006857 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190006858 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190006859 short chain dehydrogenase; Provisional; Region: PRK09291 509190006860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190006861 NAD(P) binding site [chemical binding]; other site 509190006862 active site 509190006863 Domain of unknown function (DUF336); Region: DUF336; cl01249 509190006864 classical (c) SDRs; Region: SDR_c; cd05233 509190006865 NAD(P) binding site [chemical binding]; other site 509190006866 active site 509190006867 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 509190006868 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 509190006869 active site 509190006870 metal binding site [ion binding]; metal-binding site 509190006871 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509190006872 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190006873 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 509190006874 putative effector binding pocket; other site 509190006875 putative dimerization interface [polypeptide binding]; other site 509190006876 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509190006877 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 509190006878 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190006879 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 509190006880 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 509190006881 NAD binding site [chemical binding]; other site 509190006882 catalytic Zn binding site [ion binding]; other site 509190006883 structural Zn binding site [ion binding]; other site 509190006884 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 509190006885 putative hydrophobic ligand binding site [chemical binding]; other site 509190006886 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 509190006887 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190006888 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190006889 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 509190006890 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509190006891 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509190006892 DNA binding residues [nucleotide binding] 509190006893 FecR protein; Region: FecR; pfam04773 509190006894 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 509190006895 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 509190006896 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190006897 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190006898 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 509190006899 putative active site [active] 509190006900 catalytic site [active] 509190006901 putative metal binding site [ion binding]; other site 509190006902 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 509190006903 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509190006904 DNA binding site [nucleotide binding] 509190006905 AAA ATPase domain; Region: AAA_16; pfam13191 509190006906 Predicted ATPase [General function prediction only]; Region: COG3903 509190006907 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 509190006908 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 509190006909 potential catalytic triad [active] 509190006910 conserved cys residue [active] 509190006911 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 509190006912 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509190006913 Uncharacterized conserved protein [Function unknown]; Region: COG1359 509190006914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190006915 NAD(P) binding site [chemical binding]; other site 509190006916 active site 509190006917 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509190006918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190006919 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 509190006920 putative effector binding pocket; other site 509190006921 dimerization interface [polypeptide binding]; other site 509190006922 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 509190006923 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 509190006924 NADP binding site [chemical binding]; other site 509190006925 putative substrate binding site [chemical binding]; other site 509190006926 active site 509190006927 short chain dehydrogenase; Provisional; Region: PRK06197 509190006928 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 509190006929 putative NAD(P) binding site [chemical binding]; other site 509190006930 active site 509190006931 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 509190006932 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190006933 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509190006934 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190006935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190006936 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509190006937 putative substrate translocation pore; other site 509190006938 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 509190006939 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 509190006940 NADP binding site [chemical binding]; other site 509190006941 homodimer interface [polypeptide binding]; other site 509190006942 active site 509190006943 substrate binding site [chemical binding]; other site 509190006944 MltA-interacting protein MipA; Region: MipA; cl01504 509190006945 Carboxylesterase family; Region: COesterase; pfam00135 509190006946 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 509190006947 substrate binding pocket [chemical binding]; other site 509190006948 catalytic triad [active] 509190006949 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 509190006950 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 509190006951 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 509190006952 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 509190006953 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 509190006954 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 509190006955 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 509190006956 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190006957 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190006958 N-terminal plug; other site 509190006959 ligand-binding site [chemical binding]; other site 509190006960 Transcriptional regulators [Transcription]; Region: PurR; COG1609 509190006961 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 509190006962 DNA binding site [nucleotide binding] 509190006963 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 509190006964 putative dimerization interface [polypeptide binding]; other site 509190006965 putative ligand binding site [chemical binding]; other site 509190006966 MltA-interacting protein MipA; Region: MipA; cl01504 509190006967 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 509190006968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190006969 active site 509190006970 phosphorylation site [posttranslational modification] 509190006971 intermolecular recognition site; other site 509190006972 dimerization interface [polypeptide binding]; other site 509190006973 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509190006974 DNA binding site [nucleotide binding] 509190006975 HAMP domain; Region: HAMP; pfam00672 509190006976 dimerization interface [polypeptide binding]; other site 509190006977 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190006978 dimer interface [polypeptide binding]; other site 509190006979 phosphorylation site [posttranslational modification] 509190006980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190006981 ATP binding site [chemical binding]; other site 509190006982 Mg2+ binding site [ion binding]; other site 509190006983 G-X-G motif; other site 509190006984 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 509190006985 VacJ like lipoprotein; Region: VacJ; cl01073 509190006986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190006987 dimer interface [polypeptide binding]; other site 509190006988 phosphorylation site [posttranslational modification] 509190006989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190006990 ATP binding site [chemical binding]; other site 509190006991 Mg2+ binding site [ion binding]; other site 509190006992 G-X-G motif; other site 509190006993 Response regulator receiver domain; Region: Response_reg; pfam00072 509190006994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190006995 active site 509190006996 phosphorylation site [posttranslational modification] 509190006997 intermolecular recognition site; other site 509190006998 dimerization interface [polypeptide binding]; other site 509190006999 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 509190007000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190007001 NAD(P) binding site [chemical binding]; other site 509190007002 active site 509190007003 Transcriptional regulators [Transcription]; Region: MarR; COG1846 509190007004 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 509190007005 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 509190007006 putative catalytic site [active] 509190007007 putative metal binding site [ion binding]; other site 509190007008 putative phosphate binding site [ion binding]; other site 509190007009 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 509190007010 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 509190007011 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 509190007012 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190007013 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190007014 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 509190007015 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 509190007016 catalytic core [active] 509190007017 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 509190007018 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 509190007019 OsmC-like protein; Region: OsmC; pfam02566 509190007020 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 509190007021 ArsC family; Region: ArsC; pfam03960 509190007022 catalytic residues [active] 509190007023 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 509190007024 arsenical-resistance protein; Region: acr3; TIGR00832 509190007025 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 509190007026 Low molecular weight phosphatase family; Region: LMWPc; cd00115 509190007027 active site 509190007028 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509190007029 dimerization interface [polypeptide binding]; other site 509190007030 putative DNA binding site [nucleotide binding]; other site 509190007031 putative Zn2+ binding site [ion binding]; other site 509190007032 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 509190007033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 509190007034 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 509190007035 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 509190007036 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509190007037 putative DNA binding site [nucleotide binding]; other site 509190007038 putative Zn2+ binding site [ion binding]; other site 509190007039 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 509190007040 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 509190007041 dimer interface [polypeptide binding]; other site 509190007042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190007043 catalytic residue [active] 509190007044 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 509190007045 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509190007046 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 509190007047 DNA binding residues [nucleotide binding] 509190007048 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 509190007049 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 509190007050 Walker A/P-loop; other site 509190007051 ATP binding site [chemical binding]; other site 509190007052 Q-loop/lid; other site 509190007053 ABC transporter signature motif; other site 509190007054 Walker B; other site 509190007055 D-loop; other site 509190007056 H-loop/switch region; other site 509190007057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509190007058 dimer interface [polypeptide binding]; other site 509190007059 conserved gate region; other site 509190007060 putative PBP binding loops; other site 509190007061 ABC-ATPase subunit interface; other site 509190007062 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 509190007063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 509190007064 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 509190007065 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 509190007066 substrate binding pocket [chemical binding]; other site 509190007067 membrane-bound complex binding site; other site 509190007068 hinge residues; other site 509190007069 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 509190007070 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 509190007071 active site 509190007072 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 509190007073 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 509190007074 active site 509190007075 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190007076 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 509190007077 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 509190007078 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 509190007079 active site 509190007080 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 509190007081 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 509190007082 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509190007083 putative DNA binding site [nucleotide binding]; other site 509190007084 putative Zn2+ binding site [ion binding]; other site 509190007085 AsnC family; Region: AsnC_trans_reg; pfam01037 509190007086 Antirestriction protein (ArdA); Region: ArdA; cl01953 509190007087 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 509190007088 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 509190007089 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 509190007090 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 509190007091 active site 509190007092 catalytic site [active] 509190007093 substrate binding site [chemical binding]; other site 509190007094 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 509190007095 putative catalytic site [active] 509190007096 putative metal binding site [ion binding]; other site 509190007097 putative phosphate binding site [ion binding]; other site 509190007098 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 509190007099 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 509190007100 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 509190007101 VirB7 interaction site; other site 509190007102 VirB8 protein; Region: VirB8; cl01500 509190007103 conjugal transfer protein TrbL; Provisional; Region: PRK13875 509190007104 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 509190007105 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 509190007106 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 509190007107 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 509190007108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509190007109 Walker A/P-loop; other site 509190007110 ATP binding site [chemical binding]; other site 509190007111 Q-loop/lid; other site 509190007112 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 509190007113 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 509190007114 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 509190007115 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 509190007116 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 509190007117 Walker A motif; other site 509190007118 ATP binding site [chemical binding]; other site 509190007119 Walker B motif; other site 509190007120 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 509190007121 active site 509190007122 Zn binding site [ion binding]; other site 509190007123 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 509190007124 arsenite oxidase, large subunit; Region: arsenite_ox_L; TIGR02693 509190007125 molybdopterin cofactor binding site; other site 509190007126 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 509190007127 molybdopterin cofactor binding site; other site 509190007128 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 509190007129 iron-sulfur cluster [ion binding]; other site 509190007130 [2Fe-2S] cluster binding site [ion binding]; other site 509190007131 Outer membrane efflux protein; Region: OEP; pfam02321 509190007132 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 509190007133 HlyD family secretion protein; Region: HlyD_3; pfam13437 509190007134 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 509190007135 YHS domain; Region: YHS; pfam04945 509190007136 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 509190007137 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 509190007138 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509190007139 active site 509190007140 motif I; other site 509190007141 motif II; other site 509190007142 CopC domain; Region: CopC; pfam04234 509190007143 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 509190007144 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 509190007145 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 509190007146 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 509190007147 Multicopper oxidase; Region: Cu-oxidase; pfam00394 509190007148 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 509190007149 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 509190007150 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509190007151 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509190007152 DNA binding residues [nucleotide binding] 509190007153 Outer membrane efflux protein; Region: OEP; pfam02321 509190007154 HlyD family secretion protein; Region: HlyD_2; pfam12700 509190007155 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 509190007156 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 509190007157 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 509190007158 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 509190007159 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 509190007160 dimer interface [polypeptide binding]; other site 509190007161 active site 509190007162 short chain dehydrogenase; Provisional; Region: PRK06172 509190007163 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190007164 NAD(P) binding site [chemical binding]; other site 509190007165 active site 509190007166 putative acyl-CoA synthetase; Provisional; Region: PRK06018 509190007167 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 509190007168 acyl-activating enzyme (AAE) consensus motif; other site 509190007169 AMP binding site [chemical binding]; other site 509190007170 active site 509190007171 CoA binding site [chemical binding]; other site 509190007172 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 509190007173 Carboxylesterase family; Region: COesterase; pfam00135 509190007174 substrate binding pocket [chemical binding]; other site 509190007175 catalytic triad [active] 509190007176 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190007177 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190007178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190007179 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509190007180 putative substrate translocation pore; other site 509190007181 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190007182 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190007183 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190007184 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190007185 Predicted transcriptional regulators [Transcription]; Region: COG1733 509190007186 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 509190007187 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 509190007188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190007189 NAD(P) binding site [chemical binding]; other site 509190007190 active site 509190007191 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509190007192 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190007193 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 509190007194 putative effector binding pocket; other site 509190007195 dimerization interface [polypeptide binding]; other site 509190007196 NmrA-like family; Region: NmrA; pfam05368 509190007197 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 509190007198 NADP binding site [chemical binding]; other site 509190007199 active site 509190007200 regulatory binding site [polypeptide binding]; other site 509190007201 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 509190007202 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509190007203 DNA binding site [nucleotide binding] 509190007204 Predicted ATPase [General function prediction only]; Region: COG3903 509190007205 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 509190007206 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 509190007207 potential catalytic triad [active] 509190007208 conserved cys residue [active] 509190007209 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 509190007210 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509190007211 Uncharacterized conserved protein [Function unknown]; Region: COG1359 509190007212 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 509190007213 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 509190007214 MarR family; Region: MarR_2; pfam12802 509190007215 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 509190007216 AAA domain; Region: AAA_23; pfam13476 509190007217 Family description; Region: UvrD_C_2; pfam13538 509190007218 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 509190007219 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 509190007220 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 509190007221 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 509190007222 Walker A motif; other site 509190007223 ATP binding site [chemical binding]; other site 509190007224 Walker B motif; other site 509190007225 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 509190007226 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 509190007227 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 509190007228 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 509190007229 N-acetyl-D-glucosamine binding site [chemical binding]; other site 509190007230 catalytic residue [active] 509190007231 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 509190007232 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 509190007233 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 509190007234 Helix-turn-helix domain; Region: HTH_17; pfam12728 509190007235 Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246 509190007236 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 509190007237 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509190007238 non-specific DNA binding site [nucleotide binding]; other site 509190007239 salt bridge; other site 509190007240 sequence-specific DNA binding site [nucleotide binding]; other site 509190007241 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 509190007242 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509190007243 DNA binding residues [nucleotide binding] 509190007244 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 509190007245 FecR protein; Region: FecR; pfam04773 509190007246 Secretin and TonB N terminus short domain; Region: STN; smart00965 509190007247 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190007248 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190007249 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190007250 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 509190007251 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509190007252 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 509190007253 Ligand Binding Site [chemical binding]; other site 509190007254 Molecular Tunnel; other site 509190007255 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 509190007256 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509190007257 DNA-binding site [nucleotide binding]; DNA binding site 509190007258 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509190007259 non-specific DNA binding site [nucleotide binding]; other site 509190007260 salt bridge; other site 509190007261 sequence-specific DNA binding site [nucleotide binding]; other site 509190007262 Protein of unknown function (DUF736); Region: DUF736; pfam05284 509190007263 Protein of unknown function (DUF736); Region: DUF736; cl02303 509190007264 Protein of unknown function (DUF736); Region: DUF736; cl02303 509190007265 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 509190007266 ParB-like nuclease domain; Region: ParBc; cl02129 509190007267 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 509190007268 Phosphate transporter family; Region: PHO4; pfam01384 509190007269 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 509190007270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190007271 putative substrate translocation pore; other site 509190007272 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509190007273 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 509190007274 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 509190007275 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509190007276 motif II; other site 509190007277 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 509190007278 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 509190007279 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 509190007280 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509190007281 putative DNA binding site [nucleotide binding]; other site 509190007282 dimerization interface [polypeptide binding]; other site 509190007283 putative Zn2+ binding site [ion binding]; other site 509190007284 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 509190007285 active site 509190007286 catalytic triad [active] 509190007287 integrase; Provisional; Region: PRK09692 509190007288 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 509190007289 active site 509190007290 Int/Topo IB signature motif; other site 509190007291 GMP synthase; Reviewed; Region: guaA; PRK00074 509190007292 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 509190007293 AMP/PPi binding site [chemical binding]; other site 509190007294 candidate oxyanion hole; other site 509190007295 catalytic triad [active] 509190007296 potential glutamine specificity residues [chemical binding]; other site 509190007297 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 509190007298 ATP Binding subdomain [chemical binding]; other site 509190007299 Ligand Binding sites [chemical binding]; other site 509190007300 Dimerization subdomain; other site 509190007301 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 509190007302 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 509190007303 MAPEG family; Region: MAPEG; cl09190 509190007304 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 509190007305 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 509190007306 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 509190007307 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 509190007308 active site 509190007309 Ion channel; Region: Ion_trans_2; pfam07885 509190007310 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 509190007311 TrkA-N domain; Region: TrkA_N; pfam02254 509190007312 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 509190007313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190007314 S-adenosylmethionine binding site [chemical binding]; other site 509190007315 Uncharacterized conserved protein [Function unknown]; Region: COG3785 509190007316 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 509190007317 cofactor binding site; other site 509190007318 metal binding site [ion binding]; metal-binding site 509190007319 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 509190007320 Acyltransferase family; Region: Acyl_transf_3; pfam01757 509190007321 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 509190007322 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 509190007323 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509190007324 Coenzyme A binding pocket [chemical binding]; other site 509190007325 succinylarginine dihydrolase; Provisional; Region: PRK13281 509190007326 succinylglutamic semialdehyde dehydrogenase; Region: arg_catab_astD; TIGR03240 509190007327 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 509190007328 NAD(P) binding site [chemical binding]; other site 509190007329 catalytic residues [active] 509190007330 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 509190007331 arginine and ornithine succinyltransferase subunits; Region: arg_catab_AOST; TIGR03243 509190007332 hypothetical protein; Provisional; Region: PRK07338 509190007333 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 509190007334 metal binding site [ion binding]; metal-binding site 509190007335 dimer interface [polypeptide binding]; other site 509190007336 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 509190007337 Surface antigen; Region: Bac_surface_Ag; pfam01103 509190007338 Uncharacterized conserved protein [Function unknown]; Region: COG2308 509190007339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 509190007340 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 509190007341 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 509190007342 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 509190007343 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 509190007344 PilZ domain; Region: PilZ; pfam07238 509190007345 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 509190007346 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 509190007347 Walker A/P-loop; other site 509190007348 ATP binding site [chemical binding]; other site 509190007349 Q-loop/lid; other site 509190007350 ABC transporter signature motif; other site 509190007351 Walker B; other site 509190007352 D-loop; other site 509190007353 H-loop/switch region; other site 509190007354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509190007355 dimer interface [polypeptide binding]; other site 509190007356 conserved gate region; other site 509190007357 putative PBP binding loops; other site 509190007358 ABC-ATPase subunit interface; other site 509190007359 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 509190007360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509190007361 dimer interface [polypeptide binding]; other site 509190007362 conserved gate region; other site 509190007363 putative PBP binding loops; other site 509190007364 ABC-ATPase subunit interface; other site 509190007365 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 509190007366 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 509190007367 putative trimer interface [polypeptide binding]; other site 509190007368 putative CoA binding site [chemical binding]; other site 509190007369 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 509190007370 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 509190007371 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 509190007372 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 509190007373 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 509190007374 putative catalytic site [active] 509190007375 putative metal binding site [ion binding]; other site 509190007376 putative phosphate binding site [ion binding]; other site 509190007377 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 509190007378 active site 509190007379 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 509190007380 active site 509190007381 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 509190007382 active site 509190007383 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 509190007384 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 509190007385 active site 509190007386 (T/H)XGH motif; other site 509190007387 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 509190007388 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 509190007389 CAP-like domain; other site 509190007390 active site 509190007391 primary dimer interface [polypeptide binding]; other site 509190007392 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 509190007393 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 509190007394 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 509190007395 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 509190007396 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 509190007397 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 509190007398 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 509190007399 E-class dimer interface [polypeptide binding]; other site 509190007400 P-class dimer interface [polypeptide binding]; other site 509190007401 active site 509190007402 Cu2+ binding site [ion binding]; other site 509190007403 Zn2+ binding site [ion binding]; other site 509190007404 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 509190007405 EamA-like transporter family; Region: EamA; pfam00892 509190007406 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 509190007407 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 509190007408 inhibitor-cofactor binding pocket; inhibition site 509190007409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190007410 catalytic residue [active] 509190007411 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 509190007412 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 509190007413 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509190007414 catalytic residue [active] 509190007415 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 509190007416 AAA domain; Region: AAA_26; pfam13500 509190007417 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 509190007418 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 509190007419 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 509190007420 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 509190007421 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 509190007422 ligand binding site [chemical binding]; other site 509190007423 Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935 509190007424 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 509190007425 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 509190007426 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 509190007427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190007428 NAD(P) binding site [chemical binding]; other site 509190007429 active site 509190007430 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 509190007431 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 509190007432 FMN binding site [chemical binding]; other site 509190007433 substrate binding site [chemical binding]; other site 509190007434 putative catalytic residue [active] 509190007435 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 509190007436 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 509190007437 NAD(P) binding site [chemical binding]; other site 509190007438 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 509190007439 Beta-lactamase; Region: Beta-lactamase; pfam00144 509190007440 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 509190007441 Beta-lactamase; Region: Beta-lactamase; pfam00144 509190007442 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 509190007443 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 509190007444 putative active site [active] 509190007445 putative metal binding site [ion binding]; other site 509190007446 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 509190007447 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 509190007448 Recombination protein O N terminal; Region: RecO_N; pfam11967 509190007449 Recombination protein O C terminal; Region: RecO_C; pfam02565 509190007450 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 509190007451 GTPase Era; Reviewed; Region: era; PRK00089 509190007452 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 509190007453 G1 box; other site 509190007454 GTP/Mg2+ binding site [chemical binding]; other site 509190007455 Switch I region; other site 509190007456 G2 box; other site 509190007457 Switch II region; other site 509190007458 G3 box; other site 509190007459 G4 box; other site 509190007460 G5 box; other site 509190007461 KH domain; Region: KH_2; pfam07650 509190007462 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 509190007463 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 509190007464 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 509190007465 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 509190007466 dimerization interface [polypeptide binding]; other site 509190007467 active site 509190007468 metal binding site [ion binding]; metal-binding site 509190007469 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 509190007470 dsRNA binding site [nucleotide binding]; other site 509190007471 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 509190007472 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 509190007473 Catalytic site [active] 509190007474 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 509190007475 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 509190007476 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 509190007477 active site 509190007478 hydrophilic channel; other site 509190007479 dimerization interface [polypeptide binding]; other site 509190007480 catalytic residues [active] 509190007481 active site lid [active] 509190007482 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 509190007483 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 509190007484 putative metal binding site [ion binding]; other site 509190007485 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 509190007486 active site 509190007487 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 509190007488 nudix motif; other site 509190007489 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 509190007490 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 509190007491 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 509190007492 Zn2+ binding site [ion binding]; other site 509190007493 Mg2+ binding site [ion binding]; other site 509190007494 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 509190007495 synthetase active site [active] 509190007496 NTP binding site [chemical binding]; other site 509190007497 metal binding site [ion binding]; metal-binding site 509190007498 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 509190007499 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 509190007500 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 509190007501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 509190007502 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 509190007503 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 509190007504 catalytic center binding site [active] 509190007505 ATP binding site [chemical binding]; other site 509190007506 Uncharacterized conserved protein [Function unknown]; Region: COG1432 509190007507 LabA_like proteins; Region: LabA; cd10911 509190007508 putative metal binding site [ion binding]; other site 509190007509 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 509190007510 Fe-S cluster binding site [ion binding]; other site 509190007511 DNA binding site [nucleotide binding] 509190007512 active site 509190007513 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 509190007514 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 509190007515 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 509190007516 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 509190007517 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 509190007518 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 509190007519 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 509190007520 N- and C-terminal domain interface [polypeptide binding]; other site 509190007521 active site 509190007522 MgATP binding site [chemical binding]; other site 509190007523 catalytic site [active] 509190007524 metal binding site [ion binding]; metal-binding site 509190007525 glycerol binding site [chemical binding]; other site 509190007526 homotetramer interface [polypeptide binding]; other site 509190007527 homodimer interface [polypeptide binding]; other site 509190007528 FBP binding site [chemical binding]; other site 509190007529 protein IIAGlc interface [polypeptide binding]; other site 509190007530 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 509190007531 ATP-NAD kinase; Region: NAD_kinase; pfam01513 509190007532 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 509190007533 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 509190007534 FAD binding domain; Region: FAD_binding_4; pfam01565 509190007535 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 509190007536 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 509190007537 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 509190007538 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 509190007539 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 509190007540 homodimer interface [polypeptide binding]; other site 509190007541 NADP binding site [chemical binding]; other site 509190007542 substrate binding site [chemical binding]; other site 509190007543 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 509190007544 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 509190007545 NAD(P) binding site [chemical binding]; other site 509190007546 catalytic residues [active] 509190007547 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 509190007548 hypothetical protein; Provisional; Region: PRK09256 509190007549 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 509190007550 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 509190007551 MarR family; Region: MarR_2; cl17246 509190007552 GcrA cell cycle regulator; Region: GcrA; cl11564 509190007553 Cytochrome c2 [Energy production and conversion]; Region: COG3474 509190007554 SnoaL-like domain; Region: SnoaL_2; pfam12680 509190007555 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 509190007556 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 509190007557 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 509190007558 HlyD family secretion protein; Region: HlyD_3; pfam13437 509190007559 aldolase II superfamily protein; Provisional; Region: PRK07044 509190007560 intersubunit interface [polypeptide binding]; other site 509190007561 active site 509190007562 Zn2+ binding site [ion binding]; other site 509190007563 Protein of unknown function (DUF969); Region: DUF969; pfam06149 509190007564 Predicted membrane protein [Function unknown]; Region: COG3817 509190007565 Protein of unknown function (DUF979); Region: DUF979; pfam06166 509190007566 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 509190007567 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 509190007568 SmpB-tmRNA interface; other site 509190007569 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 509190007570 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 509190007571 dimer interface [polypeptide binding]; other site 509190007572 active site 509190007573 catalytic residue [active] 509190007574 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 509190007575 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 509190007576 N-acetyl-D-glucosamine binding site [chemical binding]; other site 509190007577 catalytic residue [active] 509190007578 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 509190007579 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509190007580 Walker A/P-loop; other site 509190007581 ATP binding site [chemical binding]; other site 509190007582 Q-loop/lid; other site 509190007583 ABC transporter signature motif; other site 509190007584 Walker B; other site 509190007585 D-loop; other site 509190007586 H-loop/switch region; other site 509190007587 FecCD transport family; Region: FecCD; pfam01032 509190007588 ABC-ATPase subunit interface; other site 509190007589 dimer interface [polypeptide binding]; other site 509190007590 putative PBP binding regions; other site 509190007591 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 509190007592 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 509190007593 intersubunit interface [polypeptide binding]; other site 509190007594 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190007595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190007596 WHG domain; Region: WHG; pfam13305 509190007597 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 509190007598 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 509190007599 DXD motif; other site 509190007600 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 509190007601 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 509190007602 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 509190007603 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 509190007604 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 509190007605 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509190007606 ATP binding site [chemical binding]; other site 509190007607 putative Mg++ binding site [ion binding]; other site 509190007608 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509190007609 nucleotide binding region [chemical binding]; other site 509190007610 Helicase associated domain (HA2); Region: HA2; pfam04408 509190007611 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 509190007612 amino acid transporter; Region: 2A0306; TIGR00909 509190007613 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 509190007614 osmolarity response regulator; Provisional; Region: ompR; PRK09468 509190007615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190007616 active site 509190007617 phosphorylation site [posttranslational modification] 509190007618 intermolecular recognition site; other site 509190007619 dimerization interface [polypeptide binding]; other site 509190007620 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509190007621 DNA binding site [nucleotide binding] 509190007622 HAMP domain; Region: HAMP; pfam00672 509190007623 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190007624 dimer interface [polypeptide binding]; other site 509190007625 phosphorylation site [posttranslational modification] 509190007626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190007627 ATP binding site [chemical binding]; other site 509190007628 Mg2+ binding site [ion binding]; other site 509190007629 G-X-G motif; other site 509190007630 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 509190007631 General stress protein [General function prediction only]; Region: GsiB; COG3729 509190007632 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 509190007633 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 509190007634 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 509190007635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 509190007636 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 509190007637 haloalkane dehalogenase; Provisional; Region: PRK00870 509190007638 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 509190007639 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 509190007640 Uncharacterized conserved protein [Function unknown]; Region: COG1262 509190007641 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 509190007642 Sulfatase; Region: Sulfatase; pfam00884 509190007643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 509190007644 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 509190007645 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 509190007646 acyl-CoA synthetase; Validated; Region: PRK09192 509190007647 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 509190007648 acyl-activating enzyme (AAE) consensus motif; other site 509190007649 active site 509190007650 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 509190007651 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 509190007652 putative NAD(P) binding site [chemical binding]; other site 509190007653 active site 509190007654 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 509190007655 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 509190007656 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 509190007657 substrate-cofactor binding pocket; other site 509190007658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190007659 catalytic residue [active] 509190007660 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 509190007661 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 509190007662 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 509190007663 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 509190007664 active site 509190007665 metal binding site [ion binding]; metal-binding site 509190007666 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 509190007667 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 509190007668 nucleotide binding site/active site [active] 509190007669 HIT family signature motif; other site 509190007670 catalytic residue [active] 509190007671 Predicted permeases [General function prediction only]; Region: COG0795 509190007672 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 509190007673 Predicted permeases [General function prediction only]; Region: COG0795 509190007674 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 509190007675 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 509190007676 active site 509190007677 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 509190007678 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 509190007679 active site 509190007680 metal-binding site 509190007681 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 509190007682 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 509190007683 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 509190007684 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 509190007685 active site 509190007686 catalytic triad [active] 509190007687 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 509190007688 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 509190007689 Right handed beta helix region; Region: Beta_helix; pfam13229 509190007690 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 509190007691 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 509190007692 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190007693 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190007694 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 509190007695 metal binding site [ion binding]; metal-binding site 509190007696 active site 509190007697 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 509190007698 active site 509190007699 catalytic triad [active] 509190007700 oxyanion hole [active] 509190007701 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 509190007702 active site 509190007703 catalytic triad [active] 509190007704 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 509190007705 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 509190007706 phosphate binding site [ion binding]; other site 509190007707 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 509190007708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190007709 NAD(P) binding site [chemical binding]; other site 509190007710 active site 509190007711 Transcriptional regulator [Transcription]; Region: IclR; COG1414 509190007712 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 509190007713 Bacterial transcriptional regulator; Region: IclR; pfam01614 509190007714 L-rhamnonate dehydratase; Provisional; Region: PRK15440 509190007715 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 509190007716 putative active site pocket [active] 509190007717 putative metal binding site [ion binding]; other site 509190007718 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 509190007719 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 509190007720 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 509190007721 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190007722 NAD(P) binding site [chemical binding]; other site 509190007723 active site 509190007724 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 509190007725 Amidohydrolase; Region: Amidohydro_2; pfam04909 509190007726 Domain of unknown function (DUF718); Region: DUF718; pfam05336 509190007727 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 509190007728 active site 509190007729 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 509190007730 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 509190007731 Beta-galactosidase, domain 2; Region: BetaGal_dom2; pfam10435 509190007732 Beta-galactosidase, domain 3; Region: BetaGal_dom3; pfam13363 509190007733 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 509190007734 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 509190007735 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 509190007736 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 509190007737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190007738 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 509190007739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190007740 active site 509190007741 phosphorylation site [posttranslational modification] 509190007742 intermolecular recognition site; other site 509190007743 dimerization interface [polypeptide binding]; other site 509190007744 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 509190007745 DNA binding residues [nucleotide binding] 509190007746 dimerization interface [polypeptide binding]; other site 509190007747 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 509190007748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190007749 ATP binding site [chemical binding]; other site 509190007750 Mg2+ binding site [ion binding]; other site 509190007751 G-X-G motif; other site 509190007752 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 509190007753 ABC-2 type transporter; Region: ABC2_membrane; cl17235 509190007754 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 509190007755 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 509190007756 Walker A/P-loop; other site 509190007757 ATP binding site [chemical binding]; other site 509190007758 Q-loop/lid; other site 509190007759 ABC transporter signature motif; other site 509190007760 Walker B; other site 509190007761 D-loop; other site 509190007762 H-loop/switch region; other site 509190007763 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 509190007764 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 509190007765 NAD binding site [chemical binding]; other site 509190007766 putative substrate binding site 2 [chemical binding]; other site 509190007767 putative substrate binding site 1 [chemical binding]; other site 509190007768 active site 509190007769 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190007770 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 509190007771 N-terminal plug; other site 509190007772 ligand-binding site [chemical binding]; other site 509190007773 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190007774 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190007775 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 509190007776 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 509190007777 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190007778 N-terminal plug; other site 509190007779 ligand-binding site [chemical binding]; other site 509190007780 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 509190007781 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 509190007782 putative active site [active] 509190007783 putative catalytic site [active] 509190007784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190007785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190007786 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 509190007787 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 509190007788 Bacterial sugar transferase; Region: Bac_transf; pfam02397 509190007789 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 509190007790 Predicted integral membrane protein [Function unknown]; Region: COG5455 509190007791 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 509190007792 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 509190007793 GatB domain; Region: GatB_Yqey; smart00845 509190007794 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 509190007795 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 509190007796 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 509190007797 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 509190007798 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 509190007799 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 509190007800 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 509190007801 dihydroorotase; Validated; Region: PRK09059 509190007802 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 509190007803 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 509190007804 active site 509190007805 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 509190007806 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 509190007807 DNA protecting protein DprA; Region: dprA; TIGR00732 509190007808 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 509190007809 TPR motif; other site 509190007810 binding surface 509190007811 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 509190007812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190007813 S-adenosylmethionine binding site [chemical binding]; other site 509190007814 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 509190007815 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 509190007816 active site 509190007817 interdomain interaction site; other site 509190007818 putative metal-binding site [ion binding]; other site 509190007819 nucleotide binding site [chemical binding]; other site 509190007820 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 509190007821 domain I; other site 509190007822 DNA binding groove [nucleotide binding] 509190007823 phosphate binding site [ion binding]; other site 509190007824 domain II; other site 509190007825 domain III; other site 509190007826 nucleotide binding site [chemical binding]; other site 509190007827 catalytic site [active] 509190007828 domain IV; other site 509190007829 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 509190007830 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 509190007831 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 509190007832 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 509190007833 ribonuclease R; Region: RNase_R; TIGR02063 509190007834 RNB domain; Region: RNB; pfam00773 509190007835 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 509190007836 RNA binding site [nucleotide binding]; other site 509190007837 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 509190007838 active site 509190007839 catalytic triad [active] 509190007840 oxyanion hole [active] 509190007841 aspartate aminotransferase; Provisional; Region: PRK05764 509190007842 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509190007843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190007844 homodimer interface [polypeptide binding]; other site 509190007845 catalytic residue [active] 509190007846 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 509190007847 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 509190007848 metal binding site [ion binding]; metal-binding site 509190007849 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 509190007850 nudix motif; other site 509190007851 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 509190007852 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 509190007853 Sulfatase; Region: Sulfatase; cl17466 509190007854 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 509190007855 response regulator PleD; Reviewed; Region: pleD; PRK09581 509190007856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190007857 active site 509190007858 phosphorylation site [posttranslational modification] 509190007859 intermolecular recognition site; other site 509190007860 dimerization interface [polypeptide binding]; other site 509190007861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190007862 active site 509190007863 phosphorylation site [posttranslational modification] 509190007864 intermolecular recognition site; other site 509190007865 dimerization interface [polypeptide binding]; other site 509190007866 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 509190007867 metal binding site [ion binding]; metal-binding site 509190007868 active site 509190007869 I-site; other site 509190007870 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 509190007871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190007872 active site 509190007873 phosphorylation site [posttranslational modification] 509190007874 intermolecular recognition site; other site 509190007875 dimerization interface [polypeptide binding]; other site 509190007876 fructokinase; Reviewed; Region: PRK09557 509190007877 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 509190007878 nucleotide binding site [chemical binding]; other site 509190007879 DNA polymerase IV; Provisional; Region: PRK02794 509190007880 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 509190007881 iron binding site [ion binding]; other site 509190007882 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 509190007883 active site 509190007884 DNA binding site [nucleotide binding] 509190007885 Uncharacterized conserved protein [Function unknown]; Region: COG2127 509190007886 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 509190007887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509190007888 Walker A motif; other site 509190007889 ATP binding site [chemical binding]; other site 509190007890 Walker B motif; other site 509190007891 arginine finger; other site 509190007892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509190007893 Walker A motif; other site 509190007894 ATP binding site [chemical binding]; other site 509190007895 Walker B motif; other site 509190007896 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 509190007897 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 509190007898 HIT family signature motif; other site 509190007899 catalytic residue [active] 509190007900 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 509190007901 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 509190007902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 509190007903 Protein of unknown function, DUF482; Region: DUF482; pfam04339 509190007904 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585 509190007905 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 509190007906 putative active site [active] 509190007907 catalytic site [active] 509190007908 putative metal binding site [ion binding]; other site 509190007909 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 509190007910 homotrimer interaction site [polypeptide binding]; other site 509190007911 putative active site [active] 509190007912 Phasin protein; Region: Phasin_2; cl11491 509190007913 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 509190007914 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 509190007915 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 509190007916 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509190007917 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190007918 homodimer interface [polypeptide binding]; other site 509190007919 catalytic residue [active] 509190007920 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 509190007921 HSP70 interaction site [polypeptide binding]; other site 509190007922 ATPase MipZ; Region: MipZ; pfam09140 509190007923 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 509190007924 P-loop; other site 509190007925 Magnesium ion binding site [ion binding]; other site 509190007926 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 509190007927 Magnesium ion binding site [ion binding]; other site 509190007928 Pantoate-beta-alanine ligase; Region: PanC; cd00560 509190007929 pantoate--beta-alanine ligase; Region: panC; TIGR00018 509190007930 active site 509190007931 ATP-binding site [chemical binding]; other site 509190007932 pantoate-binding site; other site 509190007933 HXXH motif; other site 509190007934 Protein of unknown function (DUF1489); Region: DUF1489; cl11570 509190007935 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 509190007936 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 509190007937 ATP-grasp domain; Region: ATP-grasp_4; cl17255 509190007938 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 509190007939 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 509190007940 carboxyltransferase (CT) interaction site; other site 509190007941 biotinylation site [posttranslational modification]; other site 509190007942 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 509190007943 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 509190007944 enoyl-CoA hydratase; Provisional; Region: PRK05995 509190007945 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509190007946 substrate binding site [chemical binding]; other site 509190007947 oxyanion hole (OAH) forming residues; other site 509190007948 trimer interface [polypeptide binding]; other site 509190007949 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 509190007950 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 509190007951 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 509190007952 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 509190007953 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 509190007954 ligand binding site [chemical binding]; other site 509190007955 flexible hinge region; other site 509190007956 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 509190007957 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 509190007958 active site 509190007959 nucleophile elbow; other site 509190007960 isovaleryl-CoA dehydrogenase; Region: PLN02519 509190007961 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509190007962 active site 509190007963 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 509190007964 catalytic residues [active] 509190007965 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 509190007966 MgtE intracellular N domain; Region: MgtE_N; smart00924 509190007967 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 509190007968 Divalent cation transporter; Region: MgtE; pfam01769 509190007969 hypothetical protein; Validated; Region: PRK06033 509190007970 lipoate-protein ligase B; Provisional; Region: PRK14341 509190007971 Predicted membrane protein [Function unknown]; Region: COG3152 509190007972 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 509190007973 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 509190007974 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 509190007975 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 509190007976 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 509190007977 carboxyltransferase (CT) interaction site; other site 509190007978 biotinylation site [posttranslational modification]; other site 509190007979 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 509190007980 intermolecular salt bridges; other site 509190007981 Domain of unknown function (DUF336); Region: DUF336; cl01249 509190007982 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 509190007983 amidase catalytic site [active] 509190007984 Zn binding residues [ion binding]; other site 509190007985 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 509190007986 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 509190007987 conserved cys residue [active] 509190007988 methionine sulfoxide reductase B; Provisional; Region: PRK00222 509190007989 SelR domain; Region: SelR; pfam01641 509190007990 Serine hydrolase; Region: Ser_hydrolase; pfam06821 509190007991 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509190007992 short chain dehydrogenase; Provisional; Region: PRK06180 509190007993 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 509190007994 NADP binding site [chemical binding]; other site 509190007995 active site 509190007996 steroid binding site; other site 509190007997 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 509190007998 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 509190007999 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 509190008000 Transcriptional regulators [Transcription]; Region: MarR; COG1846 509190008001 MarR family; Region: MarR_2; pfam12802 509190008002 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 509190008003 transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309 509190008004 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 509190008005 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 509190008006 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190008007 N-terminal plug; other site 509190008008 ligand-binding site [chemical binding]; other site 509190008009 Predicted membrane protein [Function unknown]; Region: COG1238 509190008010 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 509190008011 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 509190008012 diiron binding motif [ion binding]; other site 509190008013 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 509190008014 Peptidase family M1; Region: Peptidase_M1; pfam01433 509190008015 Zn binding site [ion binding]; other site 509190008016 Predicted integral membrane protein [Function unknown]; Region: COG5652 509190008017 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 509190008018 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 509190008019 active site 509190008020 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 509190008021 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 509190008022 helix-hairpin-helix signature motif; other site 509190008023 substrate binding pocket [chemical binding]; other site 509190008024 active site 509190008025 transcription elongation factor regulatory protein; Validated; Region: PRK06342 509190008026 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 509190008027 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190008028 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190008029 WHG domain; Region: WHG; pfam13305 509190008030 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 509190008031 active site 509190008032 HIGH motif; other site 509190008033 nucleotide binding site [chemical binding]; other site 509190008034 active site 509190008035 KMSKS motif; other site 509190008036 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509190008037 dimerization interface [polypeptide binding]; other site 509190008038 putative DNA binding site [nucleotide binding]; other site 509190008039 Transcriptional regulators [Transcription]; Region: MarR; COG1846 509190008040 putative Zn2+ binding site [ion binding]; other site 509190008041 Transcriptional regulator PadR-like family; Region: PadR; cl17335 509190008042 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 509190008043 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 509190008044 catalytic residues [active] 509190008045 argininosuccinate lyase; Provisional; Region: PRK00855 509190008046 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 509190008047 active sites [active] 509190008048 tetramer interface [polypeptide binding]; other site 509190008049 diaminopimelate decarboxylase; Region: lysA; TIGR01048 509190008050 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 509190008051 active site 509190008052 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 509190008053 substrate binding site [chemical binding]; other site 509190008054 catalytic residues [active] 509190008055 dimer interface [polypeptide binding]; other site 509190008056 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 509190008057 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190008058 dimer interface [polypeptide binding]; other site 509190008059 putative CheW interface [polypeptide binding]; other site 509190008060 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 509190008061 active site 509190008062 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 509190008063 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 509190008064 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 509190008065 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 509190008066 Walker A/P-loop; other site 509190008067 ATP binding site [chemical binding]; other site 509190008068 Q-loop/lid; other site 509190008069 ABC transporter signature motif; other site 509190008070 Walker B; other site 509190008071 D-loop; other site 509190008072 H-loop/switch region; other site 509190008073 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 509190008074 Uncharacterized conserved protein [Function unknown]; Region: COG1434 509190008075 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 509190008076 putative active site [active] 509190008077 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 509190008078 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 509190008079 putative acyl-acceptor binding pocket; other site 509190008080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 509190008081 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 509190008082 hypothetical protein; Provisional; Region: PRK06034 509190008083 Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605 509190008084 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 509190008085 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509190008086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190008087 homodimer interface [polypeptide binding]; other site 509190008088 catalytic residue [active] 509190008089 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 509190008090 prephenate dehydrogenase; Validated; Region: PRK08507 509190008091 Ca2+ binding site [ion binding]; other site 509190008092 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 509190008093 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509190008094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190008095 dimer interface [polypeptide binding]; other site 509190008096 phosphorylation site [posttranslational modification] 509190008097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190008098 ATP binding site [chemical binding]; other site 509190008099 Mg2+ binding site [ion binding]; other site 509190008100 G-X-G motif; other site 509190008101 Response regulator receiver domain; Region: Response_reg; pfam00072 509190008102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190008103 active site 509190008104 phosphorylation site [posttranslational modification] 509190008105 intermolecular recognition site; other site 509190008106 dimerization interface [polypeptide binding]; other site 509190008107 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 509190008108 TraB family; Region: TraB; cl12050 509190008109 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509190008110 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509190008111 non-specific DNA binding site [nucleotide binding]; other site 509190008112 salt bridge; other site 509190008113 sequence-specific DNA binding site [nucleotide binding]; other site 509190008114 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 509190008115 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 509190008116 trimer interface [polypeptide binding]; other site 509190008117 active site 509190008118 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 509190008119 O-succinylhomoserine sulfhydrylase; Region: O_suc_HS_sulf; TIGR01325 509190008120 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 509190008121 homodimer interface [polypeptide binding]; other site 509190008122 substrate-cofactor binding pocket; other site 509190008123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190008124 catalytic residue [active] 509190008125 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 509190008126 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 509190008127 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 509190008128 dimerization interface [polypeptide binding]; other site 509190008129 domain crossover interface; other site 509190008130 redox-dependent activation switch; other site 509190008131 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 509190008132 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 509190008133 inhibitor-cofactor binding pocket; inhibition site 509190008134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190008135 catalytic residue [active] 509190008136 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190008137 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190008138 GcrA cell cycle regulator; Region: GcrA; pfam07750 509190008139 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 509190008140 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 509190008141 generic binding surface II; other site 509190008142 generic binding surface I; other site 509190008143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 509190008144 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 509190008145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190008146 active site 509190008147 phosphorylation site [posttranslational modification] 509190008148 intermolecular recognition site; other site 509190008149 dimerization interface [polypeptide binding]; other site 509190008150 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 509190008151 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 509190008152 putative acyl-acceptor binding pocket; other site 509190008153 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509190008154 sequence-specific DNA binding site [nucleotide binding]; other site 509190008155 salt bridge; other site 509190008156 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 509190008157 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 509190008158 active site 509190008159 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 509190008160 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 509190008161 SCP-2 sterol transfer family; Region: SCP2; cl01225 509190008162 Protein of unknown function (DUF2987); Region: DUF2987; pfam11205 509190008163 Predicted methyltransferase [General function prediction only]; Region: COG4798 509190008164 Methyltransferase domain; Region: Methyltransf_23; pfam13489 509190008165 Predicted methyltransferase [General function prediction only]; Region: COG4798 509190008166 Methyltransferase domain; Region: Methyltransf_23; pfam13489 509190008167 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 509190008168 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 509190008169 putative dimer interface [polypeptide binding]; other site 509190008170 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 509190008171 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 509190008172 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 509190008173 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 509190008174 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 509190008175 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 509190008176 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 509190008177 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 509190008178 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 509190008179 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 509190008180 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 509190008181 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 509190008182 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 509190008183 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 509190008184 catalytic core [active] 509190008185 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 509190008186 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 509190008187 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 509190008188 putative active site [active] 509190008189 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 509190008190 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 509190008191 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 509190008192 active site 509190008193 substrate binding site [chemical binding]; other site 509190008194 metal binding site [ion binding]; metal-binding site 509190008195 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 509190008196 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509190008197 Coenzyme A binding pocket [chemical binding]; other site 509190008198 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 509190008199 imidazolonepropionase; Region: hutI; TIGR01224 509190008200 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 509190008201 active site 509190008202 MASE1; Region: MASE1; cl17823 509190008203 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190008204 dimer interface [polypeptide binding]; other site 509190008205 phosphorylation site [posttranslational modification] 509190008206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190008207 ATP binding site [chemical binding]; other site 509190008208 Mg2+ binding site [ion binding]; other site 509190008209 G-X-G motif; other site 509190008210 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 509190008211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190008212 active site 509190008213 phosphorylation site [posttranslational modification] 509190008214 intermolecular recognition site; other site 509190008215 dimerization interface [polypeptide binding]; other site 509190008216 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 509190008217 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 509190008218 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 509190008219 active site 509190008220 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 509190008221 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 509190008222 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 509190008223 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 509190008224 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 509190008225 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 509190008226 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 509190008227 catalytic loop [active] 509190008228 iron binding site [ion binding]; other site 509190008229 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 509190008230 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 509190008231 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 509190008232 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 509190008233 nudix motif; other site 509190008234 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 509190008235 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 509190008236 minor groove reading motif; other site 509190008237 helix-hairpin-helix signature motif; other site 509190008238 substrate binding pocket [chemical binding]; other site 509190008239 active site 509190008240 Protein of unknown function DUF72; Region: DUF72; pfam01904 509190008241 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 509190008242 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 509190008243 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 509190008244 tetrameric interface [polypeptide binding]; other site 509190008245 NAD binding site [chemical binding]; other site 509190008246 catalytic residues [active] 509190008247 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 509190008248 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 509190008249 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 509190008250 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190008251 dimer interface [polypeptide binding]; other site 509190008252 putative CheW interface [polypeptide binding]; other site 509190008253 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 509190008254 Domain interface; other site 509190008255 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 509190008256 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 509190008257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190008258 Transcriptional regulators [Transcription]; Region: PurR; COG1609 509190008259 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 509190008260 DNA binding site [nucleotide binding] 509190008261 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 509190008262 putative dimerization interface [polypeptide binding]; other site 509190008263 putative ligand binding site [chemical binding]; other site 509190008264 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 509190008265 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 509190008266 active site 509190008267 catalytic site [active] 509190008268 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 509190008269 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 509190008270 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 509190008271 active site 509190008272 catalytic site [active] 509190008273 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 509190008274 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190008275 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190008276 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 509190008277 Uncharacterized conserved protein [Function unknown]; Region: COG2968 509190008278 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 509190008279 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 509190008280 tetramerization interface [polypeptide binding]; other site 509190008281 active site 509190008282 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 509190008283 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 509190008284 acyl-activating enzyme (AAE) consensus motif; other site 509190008285 putative AMP binding site [chemical binding]; other site 509190008286 putative active site [active] 509190008287 putative CoA binding site [chemical binding]; other site 509190008288 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 509190008289 catalytic motif [active] 509190008290 Catalytic residue [active] 509190008291 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 509190008292 O-Antigen ligase; Region: Wzy_C; pfam04932 509190008293 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 509190008294 glutathione-disulfide reductase, plant; Region: gluta_reduc_2; TIGR01424 509190008295 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 509190008296 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509190008297 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 509190008298 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 509190008299 tetramer (dimer of dimers) interface [polypeptide binding]; other site 509190008300 active site 509190008301 dimer interface [polypeptide binding]; other site 509190008302 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 509190008303 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 509190008304 Substrate binding site; other site 509190008305 Mg++ binding site; other site 509190008306 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 509190008307 active site 509190008308 substrate binding site [chemical binding]; other site 509190008309 CoA binding site [chemical binding]; other site 509190008310 phosphoglycolate phosphatase; Provisional; Region: PRK13222 509190008311 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509190008312 motif II; other site 509190008313 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 509190008314 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 509190008315 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 509190008316 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 509190008317 active site 509190008318 catalytic site [active] 509190008319 substrate binding site [chemical binding]; other site 509190008320 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 509190008321 active site 509190008322 catalytic residues [active] 509190008323 DNA binding site [nucleotide binding] 509190008324 Int/Topo IB signature motif; other site 509190008325 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 509190008326 IHF dimer interface [polypeptide binding]; other site 509190008327 IHF - DNA interface [nucleotide binding]; other site 509190008328 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 509190008329 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190008330 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190008331 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 509190008332 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 509190008333 PA/protease or protease-like domain interface [polypeptide binding]; other site 509190008334 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 509190008335 metal binding site [ion binding]; metal-binding site 509190008336 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 509190008337 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 509190008338 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 509190008339 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190008340 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190008341 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 509190008342 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 509190008343 NADP binding site [chemical binding]; other site 509190008344 substrate binding site [chemical binding]; other site 509190008345 active site 509190008346 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509190008347 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190008348 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 509190008349 putative effector binding pocket; other site 509190008350 dimerization interface [polypeptide binding]; other site 509190008351 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 509190008352 classical (c) SDRs; Region: SDR_c; cd05233 509190008353 NAD(P) binding site [chemical binding]; other site 509190008354 active site 509190008355 SnoaL-like domain; Region: SnoaL_2; pfam12680 509190008356 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 509190008357 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 509190008358 MOFRL family; Region: MOFRL; pfam05161 509190008359 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 509190008360 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190008361 N-terminal plug; other site 509190008362 ligand-binding site [chemical binding]; other site 509190008363 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 509190008364 active site 509190008365 aldolase II superfamily protein; Provisional; Region: PRK07044 509190008366 intersubunit interface [polypeptide binding]; other site 509190008367 active site 509190008368 Zn2+ binding site [ion binding]; other site 509190008369 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 509190008370 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 509190008371 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 509190008372 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 509190008373 putative ligand binding site [chemical binding]; other site 509190008374 putative NAD binding site [chemical binding]; other site 509190008375 catalytic site [active] 509190008376 cell density-dependent motility repressor; Provisional; Region: PRK10082 509190008377 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190008378 LysR substrate binding domain; Region: LysR_substrate; pfam03466 509190008379 Transcriptional regulators [Transcription]; Region: GntR; COG1802 509190008380 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509190008381 DNA-binding site [nucleotide binding]; DNA binding site 509190008382 FCD domain; Region: FCD; pfam07729 509190008383 tartrate dehydrogenase; Region: TTC; TIGR02089 509190008384 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 509190008385 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 509190008386 Citrate transporter; Region: CitMHS; pfam03600 509190008387 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 509190008388 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 509190008389 Walker A/P-loop; other site 509190008390 ATP binding site [chemical binding]; other site 509190008391 Q-loop/lid; other site 509190008392 ABC transporter signature motif; other site 509190008393 Walker B; other site 509190008394 D-loop; other site 509190008395 H-loop/switch region; other site 509190008396 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 509190008397 Permease; Region: Permease; pfam02405 509190008398 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 509190008399 mce related protein; Region: MCE; pfam02470 509190008400 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 509190008401 VacJ like lipoprotein; Region: VacJ; cl01073 509190008402 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 509190008403 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 509190008404 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509190008405 catalytic residue [active] 509190008406 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 509190008407 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 509190008408 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509190008409 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509190008410 DNA binding residues [nucleotide binding] 509190008411 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 509190008412 FecR protein; Region: FecR; pfam04773 509190008413 Secretin and TonB N terminus short domain; Region: STN; smart00965 509190008414 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190008415 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 509190008416 VacJ like lipoprotein; Region: VacJ; cl01073 509190008417 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 509190008418 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 509190008419 HlyD family secretion protein; Region: HlyD_3; pfam13437 509190008420 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 509190008421 Protein export membrane protein; Region: SecD_SecF; cl14618 509190008422 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509190008423 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 509190008424 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 509190008425 N-terminal domain interface [polypeptide binding]; other site 509190008426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190008427 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 509190008428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190008429 putative substrate translocation pore; other site 509190008430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190008431 Predicted transcriptional regulator [Transcription]; Region: COG1959 509190008432 Transcriptional regulator; Region: Rrf2; pfam02082 509190008433 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190008434 PAS domain; Region: PAS_9; pfam13426 509190008435 putative active site [active] 509190008436 heme pocket [chemical binding]; other site 509190008437 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 509190008438 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190008439 dimer interface [polypeptide binding]; other site 509190008440 putative CheW interface [polypeptide binding]; other site 509190008441 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 509190008442 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 509190008443 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 509190008444 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509190008445 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 509190008446 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 509190008447 NAD(P) binding site [chemical binding]; other site 509190008448 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 509190008449 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 509190008450 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 509190008451 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 509190008452 Cytochrome P450; Region: p450; cl12078 509190008453 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 509190008454 Strictosidine synthase; Region: Str_synth; pfam03088 509190008455 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 509190008456 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 509190008457 dimer interface [polypeptide binding]; other site 509190008458 active site 509190008459 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 509190008460 substrate binding site [chemical binding]; other site 509190008461 catalytic residue [active] 509190008462 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 509190008463 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 509190008464 FAD binding domain; Region: FAD_binding_4; pfam01565 509190008465 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 509190008466 short chain dehydrogenase; Provisional; Region: PRK05650 509190008467 classical (c) SDRs; Region: SDR_c; cd05233 509190008468 NAD(P) binding site [chemical binding]; other site 509190008469 active site 509190008470 aldolase II superfamily protein; Provisional; Region: PRK07044 509190008471 intersubunit interface [polypeptide binding]; other site 509190008472 active site 509190008473 Zn2+ binding site [ion binding]; other site 509190008474 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190008475 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190008476 N-terminal plug; other site 509190008477 ligand-binding site [chemical binding]; other site 509190008478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190008479 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190008480 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 509190008481 homotrimer interaction site [polypeptide binding]; other site 509190008482 putative active site [active] 509190008483 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 509190008484 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 509190008485 catalytic loop [active] 509190008486 iron binding site [ion binding]; other site 509190008487 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 509190008488 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 509190008489 active site 509190008490 metal binding site [ion binding]; metal-binding site 509190008491 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 509190008492 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 509190008493 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 509190008494 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509190008495 FeS/SAM binding site; other site 509190008496 HemN C-terminal domain; Region: HemN_C; pfam06969 509190008497 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 509190008498 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 509190008499 ligand binding site [chemical binding]; other site 509190008500 flexible hinge region; other site 509190008501 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 509190008502 putative switch regulator; other site 509190008503 non-specific DNA interactions [nucleotide binding]; other site 509190008504 DNA binding site [nucleotide binding] 509190008505 sequence specific DNA binding site [nucleotide binding]; other site 509190008506 putative cAMP binding site [chemical binding]; other site 509190008507 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 509190008508 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 509190008509 ligand binding site [chemical binding]; other site 509190008510 flexible hinge region; other site 509190008511 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 509190008512 putative switch regulator; other site 509190008513 non-specific DNA interactions [nucleotide binding]; other site 509190008514 DNA binding site [nucleotide binding] 509190008515 sequence specific DNA binding site [nucleotide binding]; other site 509190008516 putative cAMP binding site [chemical binding]; other site 509190008517 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 509190008518 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 509190008519 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 509190008520 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 509190008521 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 509190008522 active site 509190008523 dimer interface [polypeptide binding]; other site 509190008524 effector binding site; other site 509190008525 TSCPD domain; Region: TSCPD; pfam12637 509190008526 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 509190008527 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 509190008528 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 509190008529 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 509190008530 Hemerythrin-like domain; Region: Hr-like; cd12108 509190008531 Fe binding site [ion binding]; other site 509190008532 response regulator FixJ; Provisional; Region: fixJ; PRK09390 509190008533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190008534 active site 509190008535 phosphorylation site [posttranslational modification] 509190008536 intermolecular recognition site; other site 509190008537 dimerization interface [polypeptide binding]; other site 509190008538 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 509190008539 DNA binding residues [nucleotide binding] 509190008540 dimerization interface [polypeptide binding]; other site 509190008541 Alternative oxidase, ferritin-like diiron-binding domain; Region: AOX; cd01053 509190008542 diiron binding motif [ion binding]; other site 509190008543 cheY-homologous receiver domain; Region: REC; smart00448 509190008544 active site 509190008545 phosphorylation site [posttranslational modification] 509190008546 intermolecular recognition site; other site 509190008547 dimerization interface [polypeptide binding]; other site 509190008548 NnrS protein; Region: NnrS; pfam05940 509190008549 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190008550 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190008551 N-terminal plug; other site 509190008552 ligand-binding site [chemical binding]; other site 509190008553 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 509190008554 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 509190008555 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 509190008556 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 509190008557 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 509190008558 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 509190008559 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 509190008560 Family description; Region: VCBS; pfam13517 509190008561 Family description; Region: VCBS; pfam13517 509190008562 Family description; Region: VCBS; pfam13517 509190008563 Family description; Region: VCBS; pfam13517 509190008564 Family description; Region: VCBS; pfam13517 509190008565 Family description; Region: VCBS; pfam13517 509190008566 Cupin domain; Region: Cupin_2; pfam07883 509190008567 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509190008568 Serine hydrolase; Region: Ser_hydrolase; cl17834 509190008569 hypothetical protein; Provisional; Region: PRK06126 509190008570 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 509190008571 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 509190008572 short chain dehydrogenase; Provisional; Region: PRK07041 509190008573 classical (c) SDRs; Region: SDR_c; cd05233 509190008574 NAD(P) binding site [chemical binding]; other site 509190008575 active site 509190008576 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 509190008577 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 509190008578 homodimer interface [polypeptide binding]; other site 509190008579 active site 509190008580 TDP-binding site; other site 509190008581 acceptor substrate-binding pocket; other site 509190008582 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 509190008583 active site 509190008584 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 509190008585 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 509190008586 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190008587 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190008588 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 509190008589 Nitrogen regulatory protein P-II; Region: P-II; smart00938 509190008590 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 509190008591 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 509190008592 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190008593 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190008594 Phospholipid methyltransferase; Region: PEMT; cl17370 509190008595 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 509190008596 Cupin domain; Region: Cupin_2; cl17218 509190008597 two-component VirA-like sensor kinase; Provisional; Region: PRK13837 509190008598 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190008599 dimer interface [polypeptide binding]; other site 509190008600 phosphorylation site [posttranslational modification] 509190008601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190008602 ATP binding site [chemical binding]; other site 509190008603 Mg2+ binding site [ion binding]; other site 509190008604 G-X-G motif; other site 509190008605 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 509190008606 Cytochrome c; Region: Cytochrom_C; pfam00034 509190008607 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 509190008608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190008609 active site 509190008610 phosphorylation site [posttranslational modification] 509190008611 intermolecular recognition site; other site 509190008612 dimerization interface [polypeptide binding]; other site 509190008613 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509190008614 DNA binding site [nucleotide binding] 509190008615 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 509190008616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190008617 feruloyl-CoA synthase; Reviewed; Region: PRK08180 509190008618 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 509190008619 active site 509190008620 AMP binding site [chemical binding]; other site 509190008621 acyl-activating enzyme (AAE) consensus motif; other site 509190008622 CoA binding site [chemical binding]; other site 509190008623 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 509190008624 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509190008625 substrate binding site [chemical binding]; other site 509190008626 oxyanion hole (OAH) forming residues; other site 509190008627 trimer interface [polypeptide binding]; other site 509190008628 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 509190008629 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509190008630 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190008631 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190008632 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 509190008633 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 509190008634 putative active site [active] 509190008635 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 509190008636 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 509190008637 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509190008638 Walker A/P-loop; other site 509190008639 ATP binding site [chemical binding]; other site 509190008640 Q-loop/lid; other site 509190008641 ABC transporter signature motif; other site 509190008642 Walker B; other site 509190008643 D-loop; other site 509190008644 H-loop/switch region; other site 509190008645 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 509190008646 HlyD family secretion protein; Region: HlyD_3; pfam13437 509190008647 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 509190008648 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 509190008649 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 509190008650 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 509190008651 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 509190008652 Walker A/P-loop; other site 509190008653 ATP binding site [chemical binding]; other site 509190008654 Q-loop/lid; other site 509190008655 ABC transporter signature motif; other site 509190008656 Walker B; other site 509190008657 D-loop; other site 509190008658 H-loop/switch region; other site 509190008659 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 509190008660 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190008661 N-terminal plug; other site 509190008662 ligand-binding site [chemical binding]; other site 509190008663 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 509190008664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190008665 NAD(P) binding site [chemical binding]; other site 509190008666 active site 509190008667 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 509190008668 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 509190008669 putative ligand binding site [chemical binding]; other site 509190008670 putative NAD binding site [chemical binding]; other site 509190008671 catalytic site [active] 509190008672 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 509190008673 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 509190008674 putative N-terminal domain interface [polypeptide binding]; other site 509190008675 Predicted transcriptional regulator [Transcription]; Region: COG2378 509190008676 HTH domain; Region: HTH_11; pfam08279 509190008677 WYL domain; Region: WYL; pfam13280 509190008678 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 509190008679 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509190008680 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 509190008681 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 509190008682 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 509190008683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190008684 putative substrate translocation pore; other site 509190008685 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509190008686 Transcriptional regulators [Transcription]; Region: PurR; COG1609 509190008687 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 509190008688 DNA binding site [nucleotide binding] 509190008689 domain linker motif; other site 509190008690 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 509190008691 putative dimerization interface [polypeptide binding]; other site 509190008692 putative ligand binding site [chemical binding]; other site 509190008693 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 509190008694 heme-binding site [chemical binding]; other site 509190008695 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 509190008696 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190008697 dimer interface [polypeptide binding]; other site 509190008698 putative CheW interface [polypeptide binding]; other site 509190008699 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 509190008700 Permease; Region: Permease; pfam02405 509190008701 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 509190008702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509190008703 Walker A/P-loop; other site 509190008704 ATP binding site [chemical binding]; other site 509190008705 Q-loop/lid; other site 509190008706 ABC transporter signature motif; other site 509190008707 Walker B; other site 509190008708 D-loop; other site 509190008709 H-loop/switch region; other site 509190008710 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 509190008711 mce related protein; Region: MCE; pfam02470 509190008712 Protein of unknown function (DUF330); Region: DUF330; cl01135 509190008713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 509190008714 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 509190008715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190008716 ATP binding site [chemical binding]; other site 509190008717 Mg2+ binding site [ion binding]; other site 509190008718 G-X-G motif; other site 509190008719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190008720 active site 509190008721 phosphorylation site [posttranslational modification] 509190008722 intermolecular recognition site; other site 509190008723 dimerization interface [polypeptide binding]; other site 509190008724 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 509190008725 CoA-transferase family III; Region: CoA_transf_3; pfam02515 509190008726 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 509190008727 N-acetyl-D-glucosamine binding site [chemical binding]; other site 509190008728 catalytic residue [active] 509190008729 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 509190008730 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509190008731 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 509190008732 active site 509190008733 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 509190008734 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 509190008735 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509190008736 non-specific DNA binding site [nucleotide binding]; other site 509190008737 salt bridge; other site 509190008738 sequence-specific DNA binding site [nucleotide binding]; other site 509190008739 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 509190008740 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 509190008741 active site 509190008742 DNA binding site [nucleotide binding] 509190008743 Int/Topo IB signature motif; other site 509190008744 catalytic residues [active] 509190008745 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 509190008746 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 509190008747 putative DNA binding site [nucleotide binding]; other site 509190008748 putative homodimer interface [polypeptide binding]; other site 509190008749 SnoaL-like domain; Region: SnoaL_2; pfam12680 509190008750 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 509190008751 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 509190008752 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 509190008753 active site 509190008754 DNA binding site [nucleotide binding] 509190008755 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 509190008756 DNA binding site [nucleotide binding] 509190008757 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 509190008758 nucleotide binding site [chemical binding]; other site 509190008759 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 509190008760 IHF - DNA interface [nucleotide binding]; other site 509190008761 IHF dimer interface [polypeptide binding]; other site 509190008762 Predicted DNA-binding protein with the Helix-hairpin-helix motif [General function prediction only]; Region: COG4277 509190008763 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509190008764 FeS/SAM binding site; other site 509190008765 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 509190008766 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 509190008767 Fe-S cluster binding site [ion binding]; other site 509190008768 active site 509190008769 Hemerythrin-like domain; Region: Hr-like; cd12108 509190008770 Fe binding site [ion binding]; other site 509190008771 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 509190008772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190008773 dimer interface [polypeptide binding]; other site 509190008774 phosphorylation site [posttranslational modification] 509190008775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190008776 ATP binding site [chemical binding]; other site 509190008777 Mg2+ binding site [ion binding]; other site 509190008778 G-X-G motif; other site 509190008779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190008780 active site 509190008781 phosphorylation site [posttranslational modification] 509190008782 intermolecular recognition site; other site 509190008783 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 509190008784 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 509190008785 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 509190008786 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 509190008787 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 509190008788 Domain of unknown function (DUF329); Region: DUF329; pfam03884 509190008789 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 509190008790 Maf-like protein; Region: Maf; pfam02545 509190008791 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 509190008792 active site 509190008793 dimer interface [polypeptide binding]; other site 509190008794 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 509190008795 rRNA binding site [nucleotide binding]; other site 509190008796 predicted 30S ribosome binding site; other site 509190008797 Low molecular weight phosphatase family; Region: LMWPc; cd00115 509190008798 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 509190008799 active site 509190008800 hypothetical protein; Provisional; Region: PRK02853 509190008801 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 509190008802 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 509190008803 NAD binding site [chemical binding]; other site 509190008804 dimerization interface [polypeptide binding]; other site 509190008805 product binding site; other site 509190008806 substrate binding site [chemical binding]; other site 509190008807 zinc binding site [ion binding]; other site 509190008808 catalytic residues [active] 509190008809 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 509190008810 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 509190008811 Na binding site [ion binding]; other site 509190008812 putative substrate binding site [chemical binding]; other site 509190008813 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 509190008814 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 509190008815 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 509190008816 hinge; other site 509190008817 active site 509190008818 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 509190008819 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 509190008820 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 509190008821 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 509190008822 catalytic core [active] 509190008823 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 509190008824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 509190008825 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 509190008826 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 509190008827 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 509190008828 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 509190008829 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190008830 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190008831 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 509190008832 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 509190008833 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 509190008834 active site turn [active] 509190008835 phosphorylation site [posttranslational modification] 509190008836 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 509190008837 HPr interaction site; other site 509190008838 glycerol kinase (GK) interaction site [polypeptide binding]; other site 509190008839 active site 509190008840 phosphorylation site [posttranslational modification] 509190008841 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 509190008842 dimerization domain swap beta strand [polypeptide binding]; other site 509190008843 regulatory protein interface [polypeptide binding]; other site 509190008844 active site 509190008845 regulatory phosphorylation site [posttranslational modification]; other site 509190008846 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 509190008847 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 509190008848 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 509190008849 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 509190008850 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 509190008851 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509190008852 DNA-binding site [nucleotide binding]; DNA binding site 509190008853 UTRA domain; Region: UTRA; pfam07702 509190008854 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 509190008855 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 509190008856 dimer interface [polypeptide binding]; other site 509190008857 active site 509190008858 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 509190008859 dimer interface [polypeptide binding]; other site 509190008860 active site 509190008861 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 509190008862 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 509190008863 active site 509190008864 dimer interface [polypeptide binding]; other site 509190008865 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 509190008866 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 509190008867 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 509190008868 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190008869 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 509190008870 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 509190008871 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 509190008872 HlyD family secretion protein; Region: HlyD_3; pfam13437 509190008873 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 509190008874 Fusaric acid resistance protein family; Region: FUSC; pfam04632 509190008875 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 509190008876 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 509190008877 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 509190008878 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 509190008879 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 509190008880 active site 509190008881 dimer interface [polypeptide binding]; other site 509190008882 catalytic nucleophile [active] 509190008883 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 509190008884 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 509190008885 PspA/IM30 family; Region: PspA_IM30; pfam04012 509190008886 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 509190008887 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 509190008888 Predicted membrane protein [Function unknown]; Region: COG3766 509190008889 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 509190008890 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 509190008891 Low molecular weight phosphatase family; Region: LMWPc; cd00115 509190008892 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 509190008893 active site 509190008894 5-oxoprolinase; Region: PLN02666 509190008895 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 509190008896 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 509190008897 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 509190008898 Predicted membrane protein [Function unknown]; Region: COG2119 509190008899 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 509190008900 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 509190008901 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 509190008902 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 509190008903 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 509190008904 FMN binding site [chemical binding]; other site 509190008905 substrate binding site [chemical binding]; other site 509190008906 putative catalytic residue [active] 509190008907 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 509190008908 heterodimer interface [polypeptide binding]; other site 509190008909 substrate interaction site [chemical binding]; other site 509190008910 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 509190008911 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 509190008912 active site 509190008913 substrate binding site [chemical binding]; other site 509190008914 coenzyme B12 binding site [chemical binding]; other site 509190008915 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 509190008916 B12 binding site [chemical binding]; other site 509190008917 cobalt ligand [ion binding]; other site 509190008918 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 509190008919 ArgK protein; Region: ArgK; pfam03308 509190008920 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 509190008921 Walker A; other site 509190008922 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 509190008923 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 509190008924 DNA binding residues [nucleotide binding] 509190008925 dimerization interface [polypeptide binding]; other site 509190008926 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 509190008927 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190008928 dimer interface [polypeptide binding]; other site 509190008929 phosphorylation site [posttranslational modification] 509190008930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190008931 ATP binding site [chemical binding]; other site 509190008932 Mg2+ binding site [ion binding]; other site 509190008933 G-X-G motif; other site 509190008934 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 509190008935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190008936 active site 509190008937 phosphorylation site [posttranslational modification] 509190008938 intermolecular recognition site; other site 509190008939 dimerization interface [polypeptide binding]; other site 509190008940 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 509190008941 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 509190008942 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 509190008943 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 509190008944 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 509190008945 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 509190008946 ArsC family; Region: ArsC; pfam03960 509190008947 catalytic residues [active] 509190008948 Gram-negative bacterial tonB protein; Region: TonB; cl10048 509190008949 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 509190008950 active site 509190008951 dimer interfaces [polypeptide binding]; other site 509190008952 catalytic residues [active] 509190008953 putative aminotransferase; Provisional; Region: PRK09105 509190008954 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509190008955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190008956 homodimer interface [polypeptide binding]; other site 509190008957 catalytic residue [active] 509190008958 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 509190008959 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509190008960 TAP-like protein; Region: Abhydrolase_4; pfam08386 509190008961 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 509190008962 LytTr DNA-binding domain; Region: LytTR; pfam04397 509190008963 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 509190008964 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 509190008965 G1 box; other site 509190008966 putative GEF interaction site [polypeptide binding]; other site 509190008967 GTP/Mg2+ binding site [chemical binding]; other site 509190008968 Switch I region; other site 509190008969 G2 box; other site 509190008970 G3 box; other site 509190008971 Switch II region; other site 509190008972 G4 box; other site 509190008973 G5 box; other site 509190008974 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 509190008975 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 509190008976 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190008977 N-terminal plug; other site 509190008978 ligand-binding site [chemical binding]; other site 509190008979 Uncharacterized conserved protein [Function unknown]; Region: COG5447 509190008980 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509190008981 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190008982 dimer interface [polypeptide binding]; other site 509190008983 phosphorylation site [posttranslational modification] 509190008984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190008985 ATP binding site [chemical binding]; other site 509190008986 Mg2+ binding site [ion binding]; other site 509190008987 G-X-G motif; other site 509190008988 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509190008989 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190008990 dimer interface [polypeptide binding]; other site 509190008991 phosphorylation site [posttranslational modification] 509190008992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190008993 ATP binding site [chemical binding]; other site 509190008994 Mg2+ binding site [ion binding]; other site 509190008995 G-X-G motif; other site 509190008996 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 509190008997 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 509190008998 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509190008999 dimerization interface [polypeptide binding]; other site 509190009000 putative DNA binding site [nucleotide binding]; other site 509190009001 putative Zn2+ binding site [ion binding]; other site 509190009002 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 509190009003 transcriptional regulator protein; Region: phnR; TIGR03337 509190009004 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509190009005 DNA-binding site [nucleotide binding]; DNA binding site 509190009006 UTRA domain; Region: UTRA; pfam07702 509190009007 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 509190009008 Phosphoesterase family; Region: Phosphoesterase; pfam04185 509190009009 Domain of unknown function (DUF756); Region: DUF756; pfam05506 509190009010 Domain of unknown function (DUF756); Region: DUF756; pfam05506 509190009011 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 509190009012 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 509190009013 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 509190009014 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 509190009015 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 509190009016 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 509190009017 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 509190009018 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190009019 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190009020 ligand-binding site [chemical binding]; other site 509190009021 CHASE3 domain; Region: CHASE3; pfam05227 509190009022 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 509190009023 GAF domain; Region: GAF_2; pfam13185 509190009024 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509190009025 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 509190009026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190009027 ATP binding site [chemical binding]; other site 509190009028 Mg2+ binding site [ion binding]; other site 509190009029 G-X-G motif; other site 509190009030 Response regulator receiver domain; Region: Response_reg; pfam00072 509190009031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190009032 active site 509190009033 phosphorylation site [posttranslational modification] 509190009034 intermolecular recognition site; other site 509190009035 dimerization interface [polypeptide binding]; other site 509190009036 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 509190009037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190009038 active site 509190009039 phosphorylation site [posttranslational modification] 509190009040 intermolecular recognition site; other site 509190009041 dimerization interface [polypeptide binding]; other site 509190009042 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 509190009043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190009044 active site 509190009045 phosphorylation site [posttranslational modification] 509190009046 intermolecular recognition site; other site 509190009047 dimerization interface [polypeptide binding]; other site 509190009048 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 509190009049 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 509190009050 CheB methylesterase; Region: CheB_methylest; pfam01339 509190009051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190009052 active site 509190009053 phosphorylation site [posttranslational modification] 509190009054 intermolecular recognition site; other site 509190009055 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509190009056 dimerization interface [polypeptide binding]; other site 509190009057 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 509190009058 dimer interface [polypeptide binding]; other site 509190009059 phosphorylation site [posttranslational modification] 509190009060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190009061 ATP binding site [chemical binding]; other site 509190009062 Mg2+ binding site [ion binding]; other site 509190009063 G-X-G motif; other site 509190009064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190009065 NAD(P) binding site [chemical binding]; other site 509190009066 active site 509190009067 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 509190009068 DnaA box-binding interface [nucleotide binding]; other site 509190009069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 509190009070 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 509190009071 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 509190009072 putative NAD(P) binding site [chemical binding]; other site 509190009073 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 509190009074 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 509190009075 catalytic site [active] 509190009076 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 509190009077 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 509190009078 putative ADP-binding pocket [chemical binding]; other site 509190009079 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 509190009080 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 509190009081 putative active site [active] 509190009082 Uncharacterized conserved protein [Function unknown]; Region: COG1284 509190009083 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 509190009084 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 509190009085 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 509190009086 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 509190009087 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 509190009088 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509190009089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190009090 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509190009091 putative substrate translocation pore; other site 509190009092 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 509190009093 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 509190009094 23S rRNA binding site [nucleotide binding]; other site 509190009095 L21 binding site [polypeptide binding]; other site 509190009096 L13 binding site [polypeptide binding]; other site 509190009097 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 509190009098 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 509190009099 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 509190009100 dimer interface [polypeptide binding]; other site 509190009101 motif 1; other site 509190009102 active site 509190009103 motif 2; other site 509190009104 motif 3; other site 509190009105 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 509190009106 hypothetical protein; Provisional; Region: PRK05208 509190009107 Protein of unknown function (DUF1134); Region: DUF1134; cl02235 509190009108 GTP-binding protein LepA; Provisional; Region: PRK05433 509190009109 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 509190009110 G1 box; other site 509190009111 putative GEF interaction site [polypeptide binding]; other site 509190009112 GTP/Mg2+ binding site [chemical binding]; other site 509190009113 Switch I region; other site 509190009114 G2 box; other site 509190009115 G3 box; other site 509190009116 Switch II region; other site 509190009117 G4 box; other site 509190009118 G5 box; other site 509190009119 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 509190009120 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 509190009121 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 509190009122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509190009123 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 509190009124 Walker A motif; other site 509190009125 ATP binding site [chemical binding]; other site 509190009126 Walker B motif; other site 509190009127 arginine finger; other site 509190009128 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 509190009129 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 509190009130 active site 509190009131 catalytic triad [active] 509190009132 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 509190009133 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509190009134 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 509190009135 putative C-terminal domain interface [polypeptide binding]; other site 509190009136 putative GSH binding site (G-site) [chemical binding]; other site 509190009137 putative dimer interface [polypeptide binding]; other site 509190009138 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 509190009139 putative N-terminal domain interface [polypeptide binding]; other site 509190009140 putative dimer interface [polypeptide binding]; other site 509190009141 putative substrate binding pocket (H-site) [chemical binding]; other site 509190009142 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 509190009143 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 509190009144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 509190009145 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 509190009146 CVNH domain; Region: CVNH; pfam08881 509190009147 Beta/Gamma crystallin; Region: Crystall; pfam00030 509190009148 Entericidin EcnA/B family; Region: Entericidin; cl02322 509190009149 Protein of unknown function (DUF983); Region: DUF983; cl02211 509190009150 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 509190009151 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 509190009152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190009153 putative substrate translocation pore; other site 509190009154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190009155 Protein of unknown function, DUF599; Region: DUF599; cl01575 509190009156 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 509190009157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190009158 S-adenosylmethionine binding site [chemical binding]; other site 509190009159 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 509190009160 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 509190009161 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 509190009162 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 509190009163 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 509190009164 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 509190009165 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 509190009166 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 509190009167 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 509190009168 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 509190009169 inhibitor-cofactor binding pocket; inhibition site 509190009170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190009171 catalytic residue [active] 509190009172 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 509190009173 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 509190009174 putative trimer interface [polypeptide binding]; other site 509190009175 putative CoA binding site [chemical binding]; other site 509190009176 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 509190009177 Peptidase family M23; Region: Peptidase_M23; pfam01551 509190009178 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 509190009179 HlyD family secretion protein; Region: HlyD_3; pfam13437 509190009180 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 509190009181 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 509190009182 Walker A/P-loop; other site 509190009183 ATP binding site [chemical binding]; other site 509190009184 Q-loop/lid; other site 509190009185 ABC transporter signature motif; other site 509190009186 Walker B; other site 509190009187 D-loop; other site 509190009188 H-loop/switch region; other site 509190009189 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 509190009190 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509190009191 non-specific DNA binding site [nucleotide binding]; other site 509190009192 salt bridge; other site 509190009193 sequence-specific DNA binding site [nucleotide binding]; other site 509190009194 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 509190009195 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 509190009196 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 509190009197 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 509190009198 Cupin-like domain; Region: Cupin_8; pfam13621 509190009199 SapC; Region: SapC; pfam07277 509190009200 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190009201 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190009202 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190009203 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 509190009204 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 509190009205 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 509190009206 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 509190009207 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190009208 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190009209 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745 509190009210 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 509190009211 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 509190009212 ligand binding site [chemical binding]; other site 509190009213 flexible hinge region; other site 509190009214 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 509190009215 putative switch regulator; other site 509190009216 non-specific DNA interactions [nucleotide binding]; other site 509190009217 DNA binding site [nucleotide binding] 509190009218 sequence specific DNA binding site [nucleotide binding]; other site 509190009219 putative cAMP binding site [chemical binding]; other site 509190009220 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 509190009221 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 509190009222 ligand binding site [chemical binding]; other site 509190009223 flexible hinge region; other site 509190009224 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 509190009225 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 509190009226 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 509190009227 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 509190009228 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509190009229 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509190009230 DNA binding residues [nucleotide binding] 509190009231 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 509190009232 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 509190009233 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 509190009234 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 509190009235 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 509190009236 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 509190009237 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190009238 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190009239 N-terminal plug; other site 509190009240 ligand-binding site [chemical binding]; other site 509190009241 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 509190009242 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 509190009243 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 509190009244 putative active site [active] 509190009245 putative catalytic site [active] 509190009246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190009247 D-galactonate transporter; Region: 2A0114; TIGR00893 509190009248 putative substrate translocation pore; other site 509190009249 Tetratricopeptide repeat; Region: TPR_12; pfam13424 509190009250 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 509190009251 binding surface 509190009252 TPR motif; other site 509190009253 TPR repeat; Region: TPR_11; pfam13414 509190009254 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759 509190009255 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 509190009256 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190009257 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190009258 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 509190009259 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 509190009260 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 509190009261 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 509190009262 ligand binding site [chemical binding]; other site 509190009263 flexible hinge region; other site 509190009264 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 509190009265 DNA binding site [nucleotide binding] 509190009266 sequence specific DNA binding site [nucleotide binding]; other site 509190009267 putative cAMP binding site [chemical binding]; other site 509190009268 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819 509190009269 putative heme binding site [chemical binding]; other site 509190009270 putative substrate binding site [chemical binding]; other site 509190009271 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 509190009272 active site 509190009273 methionine sulfoxide reductase A; Provisional; Region: PRK00058 509190009274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 509190009275 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190009276 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190009277 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190009278 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190009279 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 509190009280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190009281 putative substrate translocation pore; other site 509190009282 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 509190009283 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 509190009284 active site 509190009285 iron coordination sites [ion binding]; other site 509190009286 substrate binding pocket [chemical binding]; other site 509190009287 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 509190009288 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 509190009289 inhibitor binding site; inhibition site 509190009290 active site 509190009291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190009292 D-galactonate transporter; Region: 2A0114; TIGR00893 509190009293 putative substrate translocation pore; other site 509190009294 Low affinity iron permease; Region: Iron_permease; pfam04120 509190009295 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 509190009296 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 509190009297 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 509190009298 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 509190009299 metal binding site [ion binding]; metal-binding site 509190009300 substrate binding pocket [chemical binding]; other site 509190009301 Transcriptional regulators [Transcription]; Region: FadR; COG2186 509190009302 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509190009303 DNA-binding site [nucleotide binding]; DNA binding site 509190009304 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 509190009305 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_3; cd06240 509190009306 putative active site [active] 509190009307 Zn binding site [ion binding]; other site 509190009308 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190009309 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190009310 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 509190009311 FecR protein; Region: FecR; pfam04773 509190009312 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 509190009313 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509190009314 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509190009315 DNA binding residues [nucleotide binding] 509190009316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190009317 putative substrate translocation pore; other site 509190009318 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 509190009319 active site 509190009320 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 509190009321 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 509190009322 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 509190009323 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 509190009324 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 509190009325 acyl-activating enzyme (AAE) consensus motif; other site 509190009326 acyl-activating enzyme (AAE) consensus motif; other site 509190009327 putative AMP binding site [chemical binding]; other site 509190009328 putative active site [active] 509190009329 putative CoA binding site [chemical binding]; other site 509190009330 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 509190009331 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 509190009332 Multicopper oxidase; Region: Cu-oxidase; pfam00394 509190009333 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 509190009334 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 509190009335 putative deacylase active site [active] 509190009336 Uncharacterized conserved protein [Function unknown]; Region: COG3791 509190009337 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 509190009338 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 509190009339 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509190009340 DNA-binding site [nucleotide binding]; DNA binding site 509190009341 UTRA domain; Region: UTRA; pfam07702 509190009342 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 509190009343 active sites [active] 509190009344 tetramer interface [polypeptide binding]; other site 509190009345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509190009346 putative PBP binding loops; other site 509190009347 dimer interface [polypeptide binding]; other site 509190009348 ABC-ATPase subunit interface; other site 509190009349 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 509190009350 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509190009351 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 509190009352 Walker A/P-loop; other site 509190009353 ATP binding site [chemical binding]; other site 509190009354 Q-loop/lid; other site 509190009355 ABC transporter signature motif; other site 509190009356 Walker B; other site 509190009357 D-loop; other site 509190009358 H-loop/switch region; other site 509190009359 sensory histidine kinase UhpB; Provisional; Region: PRK11644 509190009360 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509190009361 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190009362 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509190009363 dimerization interface [polypeptide binding]; other site 509190009364 Domain of unknown function (DUF897); Region: DUF897; cl01312 509190009365 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00732 509190009366 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 509190009367 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 509190009368 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004 509190009369 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 509190009370 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 509190009371 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 509190009372 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 509190009373 substrate binding site [chemical binding]; other site 509190009374 dimer interface [polypeptide binding]; other site 509190009375 ATP binding site [chemical binding]; other site 509190009376 PAS domain; Region: PAS_5; pfam07310 509190009377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 509190009378 Predicted transcriptional regulator [Transcription]; Region: COG4957 509190009379 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 509190009380 enoyl-CoA hydratase; Provisional; Region: PRK08260 509190009381 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509190009382 substrate binding site [chemical binding]; other site 509190009383 oxyanion hole (OAH) forming residues; other site 509190009384 trimer interface [polypeptide binding]; other site 509190009385 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 509190009386 Cytochrome P450; Region: p450; cl12078 509190009387 choline dehydrogenase; Validated; Region: PRK02106 509190009388 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 509190009389 Ribosomal protein S12-like family; composed of prokaryotic 30S ribosomal protein S12, eukaryotic 40S ribosomal protein S23 and similar proteins. S12 and S23 are located at the interface of the large and small ribosomal subunits, adjacent to the decoding...; Region: Ribosomal_S12_like; cl00312 509190009390 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 509190009391 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 509190009392 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 509190009393 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 509190009394 acyl-activating enzyme (AAE) consensus motif; other site 509190009395 acyl-activating enzyme (AAE) consensus motif; other site 509190009396 putative AMP binding site [chemical binding]; other site 509190009397 putative active site [active] 509190009398 putative CoA binding site [chemical binding]; other site 509190009399 manganese transport protein MntH; Reviewed; Region: PRK00701 509190009400 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 509190009401 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 509190009402 putative active site [active] 509190009403 putative catalytic site [active] 509190009404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 509190009405 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 509190009406 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 509190009407 CsbD-like; Region: CsbD; pfam05532 509190009408 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 509190009409 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 509190009410 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509190009411 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 509190009412 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509190009413 Coenzyme A binding pocket [chemical binding]; other site 509190009414 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509190009415 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190009416 dimer interface [polypeptide binding]; other site 509190009417 phosphorylation site [posttranslational modification] 509190009418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190009419 ATP binding site [chemical binding]; other site 509190009420 Mg2+ binding site [ion binding]; other site 509190009421 G-X-G motif; other site 509190009422 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 509190009423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190009424 active site 509190009425 phosphorylation site [posttranslational modification] 509190009426 intermolecular recognition site; other site 509190009427 dimerization interface [polypeptide binding]; other site 509190009428 Predicted transcriptional regulator [Transcription]; Region: COG4957 509190009429 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 509190009430 tandem repeat interface [polypeptide binding]; other site 509190009431 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 509190009432 oligomer interface [polypeptide binding]; other site 509190009433 active site residues [active] 509190009434 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 509190009435 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 509190009436 oligomer interface [polypeptide binding]; other site 509190009437 tandem repeat interface [polypeptide binding]; other site 509190009438 active site residues [active] 509190009439 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 509190009440 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 509190009441 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190009442 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190009443 Putative phosphatase (DUF442); Region: DUF442; cl17385 509190009444 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 509190009445 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 509190009446 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 509190009447 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 509190009448 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 509190009449 HSP70 interaction site [polypeptide binding]; other site 509190009450 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 509190009451 substrate binding site [polypeptide binding]; other site 509190009452 dimer interface [polypeptide binding]; other site 509190009453 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 509190009454 MarR family; Region: MarR_2; cl17246 509190009455 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 509190009456 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190009457 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190009458 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 509190009459 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 509190009460 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 509190009461 putative NAD(P) binding site [chemical binding]; other site 509190009462 putative substrate binding site [chemical binding]; other site 509190009463 catalytic Zn binding site [ion binding]; other site 509190009464 structural Zn binding site [ion binding]; other site 509190009465 dimer interface [polypeptide binding]; other site 509190009466 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 509190009467 FHIPEP family; Region: FHIPEP; pfam00771 509190009468 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 509190009469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509190009470 Walker A motif; other site 509190009471 ATP binding site [chemical binding]; other site 509190009472 Walker B motif; other site 509190009473 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 509190009474 flagellar motor switch protein; Reviewed; Region: PRK08916 509190009475 flagellar assembly protein H; Validated; Region: fliH; PRK06032 509190009476 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 509190009477 FliG C-terminal domain; Region: FliG_C; pfam01706 509190009478 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 509190009479 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 509190009480 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 509190009481 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 509190009482 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 509190009483 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 509190009484 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 509190009485 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 509190009486 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 509190009487 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 509190009488 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 509190009489 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 509190009490 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 509190009491 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 509190009492 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 509190009493 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 509190009494 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 509190009495 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 509190009496 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 509190009497 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 509190009498 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 509190009499 Ligand Binding Site [chemical binding]; other site 509190009500 Predicted transcriptional regulators [Transcription]; Region: COG1733 509190009501 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 509190009502 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 509190009503 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 509190009504 dimer interface [polypeptide binding]; other site 509190009505 active site 509190009506 Predicted acetyltransferase [General function prediction only]; Region: COG2388 509190009507 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 509190009508 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 509190009509 putative metal binding site [ion binding]; other site 509190009510 Predicted transcriptional regulators [Transcription]; Region: COG1733 509190009511 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 509190009512 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 509190009513 classical (c) SDRs; Region: SDR_c; cd05233 509190009514 NAD(P) binding site [chemical binding]; other site 509190009515 active site 509190009516 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 509190009517 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 509190009518 ligand binding site [chemical binding]; other site 509190009519 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 509190009520 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190009521 The C-terminal substrate-domain of LysR-type transcriptional regulators for beta-lactamase genes, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_beta_lactamase; cd08484 509190009522 putative dimerization interface [polypeptide binding]; other site 509190009523 putative substrate binding pocket [chemical binding]; other site 509190009524 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 509190009525 oxidoreductase; Provisional; Region: PRK06196 509190009526 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 509190009527 putative NAD(P) binding site [chemical binding]; other site 509190009528 active site 509190009529 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190009530 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190009531 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190009532 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 509190009533 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 509190009534 Clp amino terminal domain; Region: Clp_N; pfam02861 509190009535 Clp amino terminal domain; Region: Clp_N; pfam02861 509190009536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509190009537 Walker A motif; other site 509190009538 ATP binding site [chemical binding]; other site 509190009539 Walker B motif; other site 509190009540 arginine finger; other site 509190009541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509190009542 Walker A motif; other site 509190009543 ATP binding site [chemical binding]; other site 509190009544 Walker B motif; other site 509190009545 arginine finger; other site 509190009546 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 509190009547 Peptidase family M48; Region: Peptidase_M48; pfam01435 509190009548 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 509190009549 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 509190009550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190009551 S-adenosylmethionine binding site [chemical binding]; other site 509190009552 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 509190009553 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 509190009554 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 509190009555 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 509190009556 MOSC domain; Region: MOSC; pfam03473 509190009557 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 509190009558 Methyltransferase domain; Region: Methyltransf_11; pfam08241 509190009559 Methyltransferase domain; Region: Methyltransf_23; pfam13489 509190009560 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 509190009561 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509190009562 Coenzyme A binding pocket [chemical binding]; other site 509190009563 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 509190009564 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509190009565 DNA-binding site [nucleotide binding]; DNA binding site 509190009566 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509190009567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190009568 homodimer interface [polypeptide binding]; other site 509190009569 catalytic residue [active] 509190009570 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 509190009571 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 509190009572 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190009573 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190009574 quinolinate synthetase; Provisional; Region: PRK09375 509190009575 L-aspartate oxidase; Provisional; Region: PRK07512 509190009576 L-aspartate oxidase; Provisional; Region: PRK06175 509190009577 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 509190009578 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 509190009579 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 509190009580 dimerization interface [polypeptide binding]; other site 509190009581 active site 509190009582 MAPEG family; Region: MAPEG; pfam01124 509190009583 prephenate dehydratase; Provisional; Region: PRK11899 509190009584 Prephenate dehydratase; Region: PDT; pfam00800 509190009585 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 509190009586 putative L-Phe binding site [chemical binding]; other site 509190009587 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 509190009588 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 509190009589 Ligand binding site; other site 509190009590 oligomer interface; other site 509190009591 Cytochrome c2 [Energy production and conversion]; Region: COG3474 509190009592 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 509190009593 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 509190009594 catalytic residues [active] 509190009595 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 509190009596 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 509190009597 NlpC/P60 family; Region: NLPC_P60; cl17555 509190009598 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 509190009599 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 509190009600 interface (dimer of trimers) [polypeptide binding]; other site 509190009601 Substrate-binding/catalytic site; other site 509190009602 Zn-binding sites [ion binding]; other site 509190009603 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 509190009604 binding surface 509190009605 TPR motif; other site 509190009606 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 509190009607 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 509190009608 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 509190009609 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 509190009610 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 509190009611 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 509190009612 ATP binding site [chemical binding]; other site 509190009613 Walker A motif; other site 509190009614 hexamer interface [polypeptide binding]; other site 509190009615 Walker B motif; other site 509190009616 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 509190009617 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 509190009618 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 509190009619 Type IV pili component [Cell motility and secretion]; Region: COG5461 509190009620 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 509190009621 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 509190009622 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 509190009623 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 509190009624 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 509190009625 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 509190009626 Flp/Fap pilin component; Region: Flp_Fap; cl01585 509190009627 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 509190009628 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 509190009629 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 509190009630 TadE-like protein; Region: TadE; pfam07811 509190009631 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 509190009632 TadE-like protein; Region: TadE; pfam07811 509190009633 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 509190009634 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 509190009635 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 509190009636 substrate-cofactor binding pocket; other site 509190009637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190009638 homodimer interface [polypeptide binding]; other site 509190009639 catalytic residue [active] 509190009640 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 509190009641 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 509190009642 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 509190009643 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 509190009644 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 509190009645 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 509190009646 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 509190009647 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 509190009648 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 509190009649 putative active site [active] 509190009650 metal binding site [ion binding]; metal-binding site 509190009651 DJ-1 family protein; Region: not_thiJ; TIGR01383 509190009652 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 509190009653 conserved cys residue [active] 509190009654 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 509190009655 active site 509190009656 short chain dehydrogenase; Provisional; Region: PRK08267 509190009657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509190009658 NAD(P) binding site [chemical binding]; other site 509190009659 active site 509190009660 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 509190009661 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 509190009662 Predicted transcriptional regulators [Transcription]; Region: COG1695 509190009663 Transcriptional regulator PadR-like family; Region: PadR; cl17335 509190009664 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 509190009665 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 509190009666 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 509190009667 NAD binding site [chemical binding]; other site 509190009668 substrate binding site [chemical binding]; other site 509190009669 catalytic Zn binding site [ion binding]; other site 509190009670 tetramer interface [polypeptide binding]; other site 509190009671 structural Zn binding site [ion binding]; other site 509190009672 Cytochrome c; Region: Cytochrom_C; pfam00034 509190009673 MASE1; Region: MASE1; pfam05231 509190009674 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 509190009675 GAF domain; Region: GAF; pfam01590 509190009676 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 509190009677 HWE histidine kinase; Region: HWE_HK; pfam07536 509190009678 excinuclease ABC subunit B; Provisional; Region: PRK05298 509190009679 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509190009680 ATP binding site [chemical binding]; other site 509190009681 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509190009682 nucleotide binding region [chemical binding]; other site 509190009683 ATP-binding site [chemical binding]; other site 509190009684 Ultra-violet resistance protein B; Region: UvrB; pfam12344 509190009685 UvrB/uvrC motif; Region: UVR; pfam02151 509190009686 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 509190009687 Uncharacterized conserved protein [Function unknown]; Region: COG4748 509190009688 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 509190009689 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509190009690 dimerization interface [polypeptide binding]; other site 509190009691 putative DNA binding site [nucleotide binding]; other site 509190009692 putative Zn2+ binding site [ion binding]; other site 509190009693 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 509190009694 hydrophobic ligand binding site; other site 509190009695 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 509190009696 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 509190009697 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 509190009698 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 509190009699 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 509190009700 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 509190009701 TPR motif; other site 509190009702 binding surface 509190009703 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 509190009704 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 509190009705 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 509190009706 DXD motif; other site 509190009707 PilZ domain; Region: PilZ; pfam07238 509190009708 cellulose synthase regulator protein; Provisional; Region: PRK11114 509190009709 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 509190009710 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 509190009711 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190009712 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190009713 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190009714 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 509190009715 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 509190009716 FMN binding site [chemical binding]; other site 509190009717 substrate binding site [chemical binding]; other site 509190009718 putative catalytic residue [active] 509190009719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 509190009720 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 509190009721 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 509190009722 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 509190009723 Cytochrome P450; Region: p450; cl12078 509190009724 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 509190009725 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 509190009726 Mechanosensitive ion channel; Region: MS_channel; pfam00924 509190009727 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 509190009728 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 509190009729 active site 509190009730 catalytic tetrad [active] 509190009731 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 509190009732 dimer interface [polypeptide binding]; other site 509190009733 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 509190009734 PhnA protein; Region: PhnA; pfam03831 509190009735 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 509190009736 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 509190009737 active site 509190009738 DNA binding site [nucleotide binding] 509190009739 Int/Topo IB signature motif; other site 509190009740 shikimate kinase; Provisional; Region: PRK13946 509190009741 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 509190009742 ADP binding site [chemical binding]; other site 509190009743 magnesium binding site [ion binding]; other site 509190009744 putative shikimate binding site; other site 509190009745 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 509190009746 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 509190009747 active site 509190009748 dimer interface [polypeptide binding]; other site 509190009749 metal binding site [ion binding]; metal-binding site 509190009750 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 509190009751 Transcriptional regulators [Transcription]; Region: MarR; COG1846 509190009752 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509190009753 putative Zn2+ binding site [ion binding]; other site 509190009754 putative DNA binding site [nucleotide binding]; other site 509190009755 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 509190009756 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 509190009757 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 509190009758 ABC transporter; Region: ABC_tran_2; pfam12848 509190009759 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 509190009760 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 509190009761 Domain of unknown function DUF21; Region: DUF21; pfam01595 509190009762 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 509190009763 Transporter associated domain; Region: CorC_HlyC; smart01091 509190009764 GAF domain; Region: GAF; pfam01590 509190009765 GAF domain; Region: GAF_2; pfam13185 509190009766 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190009767 PAS fold; Region: PAS_3; pfam08447 509190009768 putative active site [active] 509190009769 heme pocket [chemical binding]; other site 509190009770 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 509190009771 HWE histidine kinase; Region: HWE_HK; pfam07536 509190009772 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 509190009773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190009774 active site 509190009775 phosphorylation site [posttranslational modification] 509190009776 intermolecular recognition site; other site 509190009777 dimerization interface [polypeptide binding]; other site 509190009778 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190009779 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190009780 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190009781 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 509190009782 active site 509190009783 catalytic motif [active] 509190009784 Zn binding site [ion binding]; other site 509190009785 BolA-like protein; Region: BolA; pfam01722 509190009786 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 509190009787 HSP70 interaction site [polypeptide binding]; other site 509190009788 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 509190009789 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 509190009790 active site 509190009791 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 509190009792 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 509190009793 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 509190009794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 509190009795 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 509190009796 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 509190009797 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 509190009798 NAD binding site [chemical binding]; other site 509190009799 catalytic Zn binding site [ion binding]; other site 509190009800 substrate binding site [chemical binding]; other site 509190009801 structural Zn binding site [ion binding]; other site 509190009802 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 509190009803 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 509190009804 putative metal binding site [ion binding]; other site 509190009805 Methyltransferase domain; Region: Methyltransf_31; pfam13847 509190009806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190009807 S-adenosylmethionine binding site [chemical binding]; other site 509190009808 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 509190009809 Peptidase family M23; Region: Peptidase_M23; pfam01551 509190009810 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 509190009811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190009812 active site 509190009813 phosphorylation site [posttranslational modification] 509190009814 intermolecular recognition site; other site 509190009815 dimerization interface [polypeptide binding]; other site 509190009816 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509190009817 DNA binding site [nucleotide binding] 509190009818 LytTr DNA-binding domain; Region: LytTR; pfam04397 509190009819 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 509190009820 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 509190009821 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509190009822 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 509190009823 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 509190009824 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 509190009825 Walker A motif/ATP binding site; other site 509190009826 Walker B motif; other site 509190009827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 509190009828 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 509190009829 active site 509190009830 Penicillinase repressor; Region: Pencillinase_R; cl17580 509190009831 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 509190009832 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 509190009833 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 509190009834 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 509190009835 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 509190009836 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509190009837 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 509190009838 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509190009839 DNA binding residues [nucleotide binding] 509190009840 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190009841 PAS fold; Region: PAS_3; pfam08447 509190009842 putative active site [active] 509190009843 heme pocket [chemical binding]; other site 509190009844 PAS domain S-box; Region: sensory_box; TIGR00229 509190009845 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190009846 putative active site [active] 509190009847 heme pocket [chemical binding]; other site 509190009848 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 509190009849 HWE histidine kinase; Region: HWE_HK; pfam07536 509190009850 DNA primase, catalytic core; Region: dnaG; TIGR01391 509190009851 CHC2 zinc finger; Region: zf-CHC2; pfam01807 509190009852 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 509190009853 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 509190009854 active site 509190009855 metal binding site [ion binding]; metal-binding site 509190009856 interdomain interaction site; other site 509190009857 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 509190009858 BON domain; Region: BON; pfam04972 509190009859 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 509190009860 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 509190009861 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 509190009862 protein binding site [polypeptide binding]; other site 509190009863 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 509190009864 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 509190009865 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 509190009866 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 509190009867 apolar tunnel; other site 509190009868 heme binding site [chemical binding]; other site 509190009869 dimerization interface [polypeptide binding]; other site 509190009870 Biofilm formation and stress response factor; Region: BsmA; cl01794 509190009871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 509190009872 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 509190009873 Predicted periplasmic protein (DUF2271); Region: DUF2271; cl17856 509190009874 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 509190009875 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 509190009876 ApbE family; Region: ApbE; pfam02424 509190009877 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 509190009878 Flavodoxin; Region: Flavodoxin_1; pfam00258 509190009879 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 509190009880 FAD binding pocket [chemical binding]; other site 509190009881 FAD binding motif [chemical binding]; other site 509190009882 catalytic residues [active] 509190009883 NAD binding pocket [chemical binding]; other site 509190009884 phosphate binding motif [ion binding]; other site 509190009885 beta-alpha-beta structure motif; other site 509190009886 Molybdopterin-guanine dinucleotide biosynthesis protein A [Coenzyme metabolism]; Region: MobA; COG0746 509190009887 active site 509190009888 Transcriptional regulators [Transcription]; Region: PurR; COG1609 509190009889 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 509190009890 DNA binding site [nucleotide binding] 509190009891 domain linker motif; other site 509190009892 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 509190009893 putative dimerization interface [polypeptide binding]; other site 509190009894 putative ligand binding site [chemical binding]; other site 509190009895 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 509190009896 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 509190009897 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 509190009898 classical (c) SDRs; Region: SDR_c; cd05233 509190009899 NAD(P) binding site [chemical binding]; other site 509190009900 active site 509190009901 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 509190009902 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 509190009903 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 509190009904 putative S-transferase; Provisional; Region: PRK11752 509190009905 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 509190009906 C-terminal domain interface [polypeptide binding]; other site 509190009907 GSH binding site (G-site) [chemical binding]; other site 509190009908 dimer interface [polypeptide binding]; other site 509190009909 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 509190009910 dimer interface [polypeptide binding]; other site 509190009911 N-terminal domain interface [polypeptide binding]; other site 509190009912 active site 509190009913 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 509190009914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190009915 putative substrate translocation pore; other site 509190009916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190009917 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 509190009918 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_3; cd09002 509190009919 active site 509190009920 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190009921 PAS domain; Region: PAS_9; pfam13426 509190009922 putative active site [active] 509190009923 heme pocket [chemical binding]; other site 509190009924 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190009925 PAS domain; Region: PAS_9; pfam13426 509190009926 putative active site [active] 509190009927 heme pocket [chemical binding]; other site 509190009928 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 509190009929 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190009930 dimer interface [polypeptide binding]; other site 509190009931 putative CheW interface [polypeptide binding]; other site 509190009932 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 509190009933 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 509190009934 Beta-Casp domain; Region: Beta-Casp; smart01027 509190009935 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 509190009936 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190009937 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190009938 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 509190009939 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 509190009940 HlyD family secretion protein; Region: HlyD_3; pfam13437 509190009941 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 509190009942 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 509190009943 AsnC family; Region: AsnC_trans_reg; pfam01037 509190009944 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 509190009945 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 509190009946 Active site serine [active] 509190009947 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 509190009948 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 509190009949 substrate binding pocket [chemical binding]; other site 509190009950 catalytic triad [active] 509190009951 flagellin; Reviewed; Region: PRK12687 509190009952 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 509190009953 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 509190009954 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 509190009955 PA14 domain; Region: PA14; cl08459 509190009956 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 509190009957 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 509190009958 putative active site [active] 509190009959 putative catalytic site [active] 509190009960 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 509190009961 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 509190009962 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 509190009963 active site 509190009964 intersubunit interface [polypeptide binding]; other site 509190009965 catalytic residue [active] 509190009966 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 509190009967 Na binding site [ion binding]; other site 509190009968 substrate binding site [chemical binding]; other site 509190009969 Transcriptional regulators [Transcription]; Region: FadR; COG2186 509190009970 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509190009971 DNA-binding site [nucleotide binding]; DNA binding site 509190009972 FCD domain; Region: FCD; pfam07729 509190009973 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 509190009974 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 509190009975 dimer interface [polypeptide binding]; other site 509190009976 active site 509190009977 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509190009978 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 509190009979 putative C-terminal domain interface [polypeptide binding]; other site 509190009980 putative GSH binding site (G-site) [chemical binding]; other site 509190009981 putative dimer interface [polypeptide binding]; other site 509190009982 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 509190009983 N-terminal domain interface [polypeptide binding]; other site 509190009984 substrate binding pocket (H-site) [chemical binding]; other site 509190009985 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 509190009986 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 509190009987 active site 509190009988 catalytic triad [active] 509190009989 oxyanion hole [active] 509190009990 switch loop; other site 509190009991 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 509190009992 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 509190009993 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 509190009994 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 509190009995 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 509190009996 Uncharacterized conserved protein [Function unknown]; Region: COG5460 509190009997 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190009998 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190009999 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 509190010000 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 509190010001 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 509190010002 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 509190010003 NAD(P) binding site [chemical binding]; other site 509190010004 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 509190010005 Ribonuclease P; Region: Ribonuclease_P; cl00457 509190010006 membrane protein insertase; Provisional; Region: PRK01318 509190010007 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 509190010008 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 509190010009 G1 box; other site 509190010010 GTP/Mg2+ binding site [chemical binding]; other site 509190010011 Switch I region; other site 509190010012 G2 box; other site 509190010013 G3 box; other site 509190010014 Switch II region; other site 509190010015 G4 box; other site 509190010016 G5 box; other site 509190010017 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 509190010018 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 509190010019 putative CheA interaction surface; other site 509190010020 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 509190010021 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 509190010022 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 509190010023 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 509190010024 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 509190010025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509190010026 Walker A/P-loop; other site 509190010027 ATP binding site [chemical binding]; other site 509190010028 Q-loop/lid; other site 509190010029 ABC transporter signature motif; other site 509190010030 Walker B; other site 509190010031 D-loop; other site 509190010032 H-loop/switch region; other site 509190010033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509190010034 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 509190010035 Walker A/P-loop; other site 509190010036 ATP binding site [chemical binding]; other site 509190010037 Q-loop/lid; other site 509190010038 ABC transporter signature motif; other site 509190010039 Walker B; other site 509190010040 D-loop; other site 509190010041 H-loop/switch region; other site 509190010042 PAS domain S-box; Region: sensory_box; TIGR00229 509190010043 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190010044 putative active site [active] 509190010045 heme pocket [chemical binding]; other site 509190010046 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190010047 dimer interface [polypeptide binding]; other site 509190010048 phosphorylation site [posttranslational modification] 509190010049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190010050 ATP binding site [chemical binding]; other site 509190010051 Mg2+ binding site [ion binding]; other site 509190010052 G-X-G motif; other site 509190010053 response regulator FixJ; Provisional; Region: fixJ; PRK09390 509190010054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190010055 active site 509190010056 phosphorylation site [posttranslational modification] 509190010057 intermolecular recognition site; other site 509190010058 dimerization interface [polypeptide binding]; other site 509190010059 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 509190010060 DNA binding residues [nucleotide binding] 509190010061 dimerization interface [polypeptide binding]; other site 509190010062 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 509190010063 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 509190010064 ligand binding site [chemical binding]; other site 509190010065 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 509190010066 putative switch regulator; other site 509190010067 non-specific DNA interactions [nucleotide binding]; other site 509190010068 DNA binding site [nucleotide binding] 509190010069 sequence specific DNA binding site [nucleotide binding]; other site 509190010070 putative cAMP binding site [chemical binding]; other site 509190010071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190010072 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509190010073 putative substrate translocation pore; other site 509190010074 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 509190010075 flagellar motor protein MotA; Validated; Region: PRK09110 509190010076 Uncharacterized conserved protein [Function unknown]; Region: COG4121 509190010077 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 509190010078 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 509190010079 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 509190010080 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 509190010081 ligand binding site [chemical binding]; other site 509190010082 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 509190010083 active site 509190010084 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 509190010085 Response regulator receiver domain; Region: Response_reg; pfam00072 509190010086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190010087 active site 509190010088 phosphorylation site [posttranslational modification] 509190010089 intermolecular recognition site; other site 509190010090 dimerization interface [polypeptide binding]; other site 509190010091 N-formylglutamate amidohydrolase; Region: FGase; cl01522 509190010092 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 509190010093 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 509190010094 G1 box; other site 509190010095 putative GEF interaction site [polypeptide binding]; other site 509190010096 GTP/Mg2+ binding site [chemical binding]; other site 509190010097 Switch I region; other site 509190010098 G2 box; other site 509190010099 G3 box; other site 509190010100 Switch II region; other site 509190010101 G4 box; other site 509190010102 G5 box; other site 509190010103 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 509190010104 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 509190010105 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190010106 PAS domain; Region: PAS_9; pfam13426 509190010107 putative active site [active] 509190010108 heme pocket [chemical binding]; other site 509190010109 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 509190010110 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 509190010111 metal binding site [ion binding]; metal-binding site 509190010112 active site 509190010113 I-site; other site 509190010114 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 509190010115 hypothetical protein; Provisional; Region: PRK08912 509190010116 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509190010117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190010118 homodimer interface [polypeptide binding]; other site 509190010119 catalytic residue [active] 509190010120 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 509190010121 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 509190010122 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 509190010123 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 509190010124 Isochorismatase family; Region: Isochorismatase; pfam00857 509190010125 dimer interface [polypeptide binding]; other site 509190010126 catalytic triad [active] 509190010127 conserved cis-peptide bond; other site 509190010128 Pirin-related protein [General function prediction only]; Region: COG1741 509190010129 Pirin; Region: Pirin; pfam02678 509190010130 Predicted membrane protein [Function unknown]; Region: COG2259 509190010131 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509190010132 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190010133 LysR substrate binding domain; Region: LysR_substrate; pfam03466 509190010134 dimerization interface [polypeptide binding]; other site 509190010135 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509190010136 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190010137 dimer interface [polypeptide binding]; other site 509190010138 phosphorylation site [posttranslational modification] 509190010139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190010140 ATP binding site [chemical binding]; other site 509190010141 Mg2+ binding site [ion binding]; other site 509190010142 G-X-G motif; other site 509190010143 Response regulator receiver domain; Region: Response_reg; pfam00072 509190010144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190010145 active site 509190010146 phosphorylation site [posttranslational modification] 509190010147 intermolecular recognition site; other site 509190010148 dimerization interface [polypeptide binding]; other site 509190010149 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 509190010150 classical (c) SDRs; Region: SDR_c; cd05233 509190010151 NAD(P) binding site [chemical binding]; other site 509190010152 active site 509190010153 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 509190010154 putative hydrophobic ligand binding site [chemical binding]; other site 509190010155 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 509190010156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190010157 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509190010158 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 509190010159 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 509190010160 B12 binding site [chemical binding]; other site 509190010161 cobalt ligand [ion binding]; other site 509190010162 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 509190010163 enoyl-CoA hydratase; Provisional; Region: PRK07658 509190010164 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509190010165 substrate binding site [chemical binding]; other site 509190010166 oxyanion hole (OAH) forming residues; other site 509190010167 trimer interface [polypeptide binding]; other site 509190010168 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 509190010169 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 509190010170 NAD(P) binding site [chemical binding]; other site 509190010171 Predicted membrane protein [Function unknown]; Region: COG2311 509190010172 Protein of unknown function (DUF418); Region: DUF418; cl12135 509190010173 Protein of unknown function (DUF418); Region: DUF418; pfam04235 509190010174 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 509190010175 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 509190010176 metal binding site [ion binding]; metal-binding site 509190010177 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 509190010178 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 509190010179 [2Fe-2S] cluster binding site [ion binding]; other site 509190010180 Bacterial SH3 domain; Region: SH3_3; cl17532 509190010181 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509190010182 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 509190010183 putative C-terminal domain interface [polypeptide binding]; other site 509190010184 putative GSH binding site (G-site) [chemical binding]; other site 509190010185 putative dimer interface [polypeptide binding]; other site 509190010186 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 509190010187 putative N-terminal domain interface [polypeptide binding]; other site 509190010188 putative dimer interface [polypeptide binding]; other site 509190010189 putative substrate binding pocket (H-site) [chemical binding]; other site 509190010190 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509190010191 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509190010192 active site 509190010193 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 509190010194 Beta-lactamase; Region: Beta-lactamase; pfam00144 509190010195 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 509190010196 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190010197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190010198 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190010199 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190010200 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 509190010201 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 509190010202 Ligand binding site [chemical binding]; other site 509190010203 Electron transfer flavoprotein domain; Region: ETF; pfam01012 509190010204 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 509190010205 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 509190010206 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 509190010207 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 509190010208 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190010209 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 509190010210 dimerization interface [polypeptide binding]; other site 509190010211 substrate binding pocket [chemical binding]; other site 509190010212 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 509190010213 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509190010214 FeS/SAM binding site; other site 509190010215 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 509190010216 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 509190010217 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 509190010218 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 509190010219 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 509190010220 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190010221 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 509190010222 GTP/Mg2+ binding site [chemical binding]; other site 509190010223 G5 box; other site 509190010224 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 509190010225 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 509190010226 G1 box; other site 509190010227 G1 box; other site 509190010228 GTP/Mg2+ binding site [chemical binding]; other site 509190010229 Switch I region; other site 509190010230 G2 box; other site 509190010231 G3 box; other site 509190010232 Switch II region; other site 509190010233 G4 box; other site 509190010234 G5 box; other site 509190010235 Nucleoside recognition; Region: Gate; pfam07670 509190010236 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 509190010237 Nucleoside recognition; Region: Gate; pfam07670 509190010238 FeoA domain; Region: FeoA; pfam04023 509190010239 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 509190010240 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 509190010241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 509190010242 NnrU protein; Region: NnrU; pfam07298 509190010243 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 509190010244 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 509190010245 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 509190010246 dimer interaction site [polypeptide binding]; other site 509190010247 substrate-binding tunnel; other site 509190010248 active site 509190010249 catalytic site [active] 509190010250 substrate binding site [chemical binding]; other site 509190010251 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 509190010252 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 509190010253 active site 509190010254 Riboflavin kinase; Region: Flavokinase; pfam01687 509190010255 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 509190010256 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 509190010257 active site 509190010258 HIGH motif; other site 509190010259 nucleotide binding site [chemical binding]; other site 509190010260 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 509190010261 active site 509190010262 KMSKS motif; other site 509190010263 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 509190010264 tRNA binding surface [nucleotide binding]; other site 509190010265 anticodon binding site; other site 509190010266 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 509190010267 Protein of unknown function (DUF3035); Region: DUF3035; pfam11233 509190010268 TraB family; Region: TraB; pfam01963 509190010269 TraB family; Region: TraB; pfam01963 509190010270 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 509190010271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190010272 ATP binding site [chemical binding]; other site 509190010273 Mg2+ binding site [ion binding]; other site 509190010274 G-X-G motif; other site 509190010275 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 509190010276 ATP binding site [chemical binding]; other site 509190010277 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 509190010278 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 509190010279 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 509190010280 DNA binding residues [nucleotide binding] 509190010281 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 509190010282 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 509190010283 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 509190010284 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509190010285 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509190010286 active site 509190010287 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 509190010288 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 509190010289 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 509190010290 DNA binding site [nucleotide binding] 509190010291 active site 509190010292 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 509190010293 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 509190010294 oligomerisation interface [polypeptide binding]; other site 509190010295 mobile loop; other site 509190010296 roof hairpin; other site 509190010297 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 509190010298 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 509190010299 ring oligomerisation interface [polypeptide binding]; other site 509190010300 ATP/Mg binding site [chemical binding]; other site 509190010301 stacking interactions; other site 509190010302 hinge regions; other site 509190010303 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 509190010304 putative active site [active] 509190010305 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 509190010306 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 509190010307 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 509190010308 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 509190010309 metal ion-dependent adhesion site (MIDAS); other site 509190010310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 509190010311 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 509190010312 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 509190010313 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 509190010314 active site 509190010315 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 509190010316 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 509190010317 active site 509190010318 nucleotide binding site [chemical binding]; other site 509190010319 HIGH motif; other site 509190010320 KMSKS motif; other site 509190010321 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 509190010322 nudix motif; other site 509190010323 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 509190010324 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 509190010325 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 509190010326 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 509190010327 DNA binding site [nucleotide binding] 509190010328 active site 509190010329 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 509190010330 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 509190010331 active site 509190010332 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 509190010333 ATP binding site [chemical binding]; other site 509190010334 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 509190010335 putative Mg++ binding site [ion binding]; other site 509190010336 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509190010337 nucleotide binding region [chemical binding]; other site 509190010338 ATP-binding site [chemical binding]; other site 509190010339 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509190010340 RNA binding surface [nucleotide binding]; other site 509190010341 PAS fold; Region: PAS_4; pfam08448 509190010342 PAS fold; Region: PAS_3; pfam08447 509190010343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190010344 putative active site [active] 509190010345 heme pocket [chemical binding]; other site 509190010346 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 509190010347 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 509190010348 metal binding site [ion binding]; metal-binding site 509190010349 active site 509190010350 I-site; other site 509190010351 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 509190010352 Ferredoxin [Energy production and conversion]; Region: COG1146 509190010353 4Fe-4S binding domain; Region: Fer4; pfam00037 509190010354 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 509190010355 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 509190010356 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 509190010357 Beta-lactamase; Region: Beta-lactamase; pfam00144 509190010358 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 509190010359 cyclase homology domain; Region: CHD; cd07302 509190010360 nucleotidyl binding site; other site 509190010361 metal binding site [ion binding]; metal-binding site 509190010362 dimer interface [polypeptide binding]; other site 509190010363 TIR domain; Region: TIR_2; pfam13676 509190010364 Tetratricopeptide repeat; Region: TPR_12; pfam13424 509190010365 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 509190010366 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 509190010367 ligand binding site [chemical binding]; other site 509190010368 flexible hinge region; other site 509190010369 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 509190010370 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 509190010371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190010372 active site 509190010373 phosphorylation site [posttranslational modification] 509190010374 intermolecular recognition site; other site 509190010375 dimerization interface [polypeptide binding]; other site 509190010376 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 509190010377 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509190010378 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190010379 dimer interface [polypeptide binding]; other site 509190010380 phosphorylation site [posttranslational modification] 509190010381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190010382 ATP binding site [chemical binding]; other site 509190010383 Mg2+ binding site [ion binding]; other site 509190010384 G-X-G motif; other site 509190010385 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 509190010386 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 509190010387 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 509190010388 Subunit I/III interface [polypeptide binding]; other site 509190010389 Subunit III/IV interface [polypeptide binding]; other site 509190010390 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 509190010391 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 509190010392 D-pathway; other site 509190010393 Putative ubiquinol binding site [chemical binding]; other site 509190010394 Low-spin heme (heme b) binding site [chemical binding]; other site 509190010395 Putative water exit pathway; other site 509190010396 Binuclear center (heme o3/CuB) [ion binding]; other site 509190010397 K-pathway; other site 509190010398 Putative proton exit pathway; other site 509190010399 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 509190010400 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 509190010401 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 509190010402 metabolite-proton symporter; Region: 2A0106; TIGR00883 509190010403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190010404 putative substrate translocation pore; other site 509190010405 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 509190010406 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 509190010407 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 509190010408 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190010409 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190010410 Transcriptional regulators [Transcription]; Region: PurR; COG1609 509190010411 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 509190010412 DNA binding site [nucleotide binding] 509190010413 domain linker motif; other site 509190010414 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 509190010415 putative dimerization interface [polypeptide binding]; other site 509190010416 putative ligand binding site [chemical binding]; other site 509190010417 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 509190010418 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 509190010419 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 509190010420 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 509190010421 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 509190010422 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 509190010423 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 509190010424 active site turn [active] 509190010425 phosphorylation site [posttranslational modification] 509190010426 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 509190010427 HPr interaction site; other site 509190010428 glycerol kinase (GK) interaction site [polypeptide binding]; other site 509190010429 active site 509190010430 phosphorylation site [posttranslational modification] 509190010431 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 509190010432 dimerization domain swap beta strand [polypeptide binding]; other site 509190010433 regulatory protein interface [polypeptide binding]; other site 509190010434 active site 509190010435 regulatory phosphorylation site [posttranslational modification]; other site 509190010436 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 509190010437 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 509190010438 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 509190010439 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 509190010440 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 509190010441 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 509190010442 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 509190010443 active site 509190010444 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C_1; pfam13290 509190010445 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 509190010446 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190010447 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190010448 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 509190010449 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509190010450 DNA-binding site [nucleotide binding]; DNA binding site 509190010451 UTRA domain; Region: UTRA; pfam07702 509190010452 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 509190010453 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 509190010454 active site 509190010455 dimer interface [polypeptide binding]; other site 509190010456 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 509190010457 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190010458 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190010459 ligand-binding site [chemical binding]; other site 509190010460 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 509190010461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190010462 active site 509190010463 phosphorylation site [posttranslational modification] 509190010464 intermolecular recognition site; other site 509190010465 dimerization interface [polypeptide binding]; other site 509190010466 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 509190010467 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 509190010468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190010469 active site 509190010470 phosphorylation site [posttranslational modification] 509190010471 intermolecular recognition site; other site 509190010472 dimerization interface [polypeptide binding]; other site 509190010473 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 509190010474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190010475 active site 509190010476 phosphorylation site [posttranslational modification] 509190010477 intermolecular recognition site; other site 509190010478 dimerization interface [polypeptide binding]; other site 509190010479 CheB methylesterase; Region: CheB_methylest; pfam01339 509190010480 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 509190010481 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 509190010482 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 509190010483 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 509190010484 putative CheA interaction surface; other site 509190010485 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 509190010486 putative binding surface; other site 509190010487 active site 509190010488 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 509190010489 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 509190010490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190010491 ATP binding site [chemical binding]; other site 509190010492 Mg2+ binding site [ion binding]; other site 509190010493 G-X-G motif; other site 509190010494 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 509190010495 Response regulator receiver domain; Region: Response_reg; pfam00072 509190010496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190010497 active site 509190010498 phosphorylation site [posttranslational modification] 509190010499 intermolecular recognition site; other site 509190010500 dimerization interface [polypeptide binding]; other site 509190010501 STAS domain; Region: STAS_2; pfam13466 509190010502 HAMP domain; Region: HAMP; pfam00672 509190010503 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 509190010504 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 509190010505 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190010506 dimer interface [polypeptide binding]; other site 509190010507 putative CheW interface [polypeptide binding]; other site 509190010508 Gram-negative bacterial tonB protein; Region: TonB; cl10048 509190010509 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 509190010510 heme-binding site [chemical binding]; other site 509190010511 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 509190010512 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190010513 dimer interface [polypeptide binding]; other site 509190010514 putative CheW interface [polypeptide binding]; other site 509190010515 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509190010516 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509190010517 active site 509190010518 amino acid transporter; Region: 2A0306; TIGR00909 509190010519 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 509190010520 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 509190010521 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509190010522 putative DNA binding site [nucleotide binding]; other site 509190010523 putative Zn2+ binding site [ion binding]; other site 509190010524 AsnC family; Region: AsnC_trans_reg; pfam01037 509190010525 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509190010526 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 509190010527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190010528 homodimer interface [polypeptide binding]; other site 509190010529 catalytic residue [active] 509190010530 Cupin-like domain; Region: Cupin_8; pfam13621 509190010531 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190010532 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190010533 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 509190010534 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 509190010535 putative active site [active] 509190010536 putative metal binding site [ion binding]; other site 509190010537 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 509190010538 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 509190010539 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 509190010540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190010541 putative substrate translocation pore; other site 509190010542 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509190010543 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190010544 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509190010545 dimerization interface [polypeptide binding]; other site 509190010546 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 509190010547 Domain of unknown function DUF21; Region: DUF21; pfam01595 509190010548 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 509190010549 Transporter associated domain; Region: CorC_HlyC; smart01091 509190010550 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 509190010551 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 509190010552 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 509190010553 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 509190010554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509190010555 dimer interface [polypeptide binding]; other site 509190010556 conserved gate region; other site 509190010557 ABC-ATPase subunit interface; other site 509190010558 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 509190010559 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 509190010560 substrate binding pocket [chemical binding]; other site 509190010561 membrane-bound complex binding site; other site 509190010562 hinge residues; other site 509190010563 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 509190010564 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 509190010565 Walker A/P-loop; other site 509190010566 ATP binding site [chemical binding]; other site 509190010567 Q-loop/lid; other site 509190010568 ABC transporter signature motif; other site 509190010569 Walker B; other site 509190010570 D-loop; other site 509190010571 H-loop/switch region; other site 509190010572 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 509190010573 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 509190010574 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 509190010575 catalytic residue [active] 509190010576 Predicted integral membrane protein [Function unknown]; Region: COG5617 509190010577 deoxyhypusine synthase-like protein; Provisional; Region: PRK02492 509190010578 deoxyhypusine synthase; Region: dhys; TIGR00321 509190010579 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 509190010580 active site 509190010581 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 509190010582 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 509190010583 Predicted transcriptional regulators [Transcription]; Region: COG1695 509190010584 metal binding site 2 [ion binding]; metal-binding site 509190010585 putative DNA binding helix; other site 509190010586 metal binding site 1 [ion binding]; metal-binding site 509190010587 dimer interface [polypeptide binding]; other site 509190010588 structural Zn2+ binding site [ion binding]; other site 509190010589 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 509190010590 active site 509190010591 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 509190010592 active site 509190010593 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 509190010594 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 509190010595 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 509190010596 catalytic site [active] 509190010597 Protein of unknown function, DUF488; Region: DUF488; pfam04343 509190010598 Bacterial SH3 domain; Region: SH3_3; pfam08239 509190010599 enoyl-CoA hydratase; Provisional; Region: PRK06142 509190010600 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509190010601 substrate binding site [chemical binding]; other site 509190010602 oxyanion hole (OAH) forming residues; other site 509190010603 trimer interface [polypeptide binding]; other site 509190010604 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 509190010605 TAP-like protein; Region: Abhydrolase_4; pfam08386 509190010606 MltA-interacting protein MipA; Region: MipA; cl01504 509190010607 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 509190010608 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 509190010609 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 509190010610 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 509190010611 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 509190010612 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 509190010613 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 509190010614 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 509190010615 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 509190010616 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 509190010617 Cl binding site [ion binding]; other site 509190010618 oligomer interface [polypeptide binding]; other site 509190010619 Surface antigen [General function prediction only]; Region: COG3942 509190010620 CHAP domain; Region: CHAP; pfam05257 509190010621 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 509190010622 PBP superfamily domain; Region: PBP_like_2; cl17296 509190010623 primosome assembly protein PriA; Validated; Region: PRK05580 509190010624 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509190010625 ATP binding site [chemical binding]; other site 509190010626 putative Mg++ binding site [ion binding]; other site 509190010627 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509190010628 nucleotide binding region [chemical binding]; other site 509190010629 ATP-binding site [chemical binding]; other site 509190010630 Protein of unknown function, DUF484; Region: DUF484; cl17449 509190010631 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 509190010632 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 509190010633 active site 509190010634 DNA binding site [nucleotide binding] 509190010635 Int/Topo IB signature motif; other site 509190010636 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 509190010637 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190010638 dimer interface [polypeptide binding]; other site 509190010639 putative CheW interface [polypeptide binding]; other site 509190010640 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115 509190010641 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 509190010642 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509190010643 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 509190010644 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 509190010645 Protein of unknown function (DUF3088); Region: DUF3088; pfam11287 509190010646 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 509190010647 E3 interaction surface; other site 509190010648 lipoyl attachment site [posttranslational modification]; other site 509190010649 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 509190010650 e3 binding domain; Region: E3_binding; pfam02817 509190010651 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 509190010652 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 509190010653 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 509190010654 TPP-binding site [chemical binding]; other site 509190010655 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 509190010656 dimer interface [polypeptide binding]; other site 509190010657 PYR/PP interface [polypeptide binding]; other site 509190010658 TPP binding site [chemical binding]; other site 509190010659 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 509190010660 CoA binding domain; Region: CoA_binding; pfam02629 509190010661 CoA-ligase; Region: Ligase_CoA; pfam00549 509190010662 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 509190010663 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 509190010664 CoA-ligase; Region: Ligase_CoA; pfam00549 509190010665 GH18 domain of an uncharacterized family of bacterial proteins, which share a common three-domain architecture: an N-terminal glycosyl hydrolase family 18 (GH18) domain, a glycosyl transferase family 2 domain, and a C-terminal polysaccharide deacetylase...; Region: GH18_trifunctional; cd06549 509190010666 Glyco_18 domain; Region: Glyco_18; smart00636 509190010667 putative active site [active] 509190010668 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 509190010669 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 509190010670 NodB motif; other site 509190010671 putative active site [active] 509190010672 putative catalytic site [active] 509190010673 putative Zn binding site [ion binding]; other site 509190010674 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 509190010675 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 509190010676 DXD motif; other site 509190010677 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190010678 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190010679 N-terminal plug; other site 509190010680 ligand-binding site [chemical binding]; other site 509190010681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190010682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190010683 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 509190010684 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 509190010685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704 509190010686 Predicted membrane protein [Function unknown]; Region: COG5395 509190010687 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 509190010688 LytTr DNA-binding domain; Region: LytTR; pfam04397 509190010689 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 509190010690 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 509190010691 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 509190010692 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 509190010693 HlyD family secretion protein; Region: HlyD_3; pfam13437 509190010694 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190010695 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190010696 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 509190010697 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 509190010698 DNA binding residues [nucleotide binding] 509190010699 dimerization interface [polypeptide binding]; other site 509190010700 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 509190010701 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509190010702 active site 509190010703 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190010704 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190010705 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190010706 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 509190010707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509190010708 dimer interface [polypeptide binding]; other site 509190010709 conserved gate region; other site 509190010710 putative PBP binding loops; other site 509190010711 ABC-ATPase subunit interface; other site 509190010712 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 509190010713 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 509190010714 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 509190010715 MarR family; Region: MarR_2; pfam12802 509190010716 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 509190010717 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 509190010718 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 509190010719 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 509190010720 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 509190010721 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 509190010722 putative C-terminal domain interface [polypeptide binding]; other site 509190010723 putative GSH binding site (G-site) [chemical binding]; other site 509190010724 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509190010725 putative dimer interface [polypeptide binding]; other site 509190010726 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 509190010727 N-terminal domain interface [polypeptide binding]; other site 509190010728 dimer interface [polypeptide binding]; other site 509190010729 substrate binding pocket (H-site) [chemical binding]; other site 509190010730 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 509190010731 Transglycosylase; Region: Transgly; cl17702 509190010732 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 509190010733 putative FMN binding site [chemical binding]; other site 509190010734 FOG: WD40 repeat [General function prediction only]; Region: COG2319 509190010735 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 509190010736 structural tetrad; other site 509190010737 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 509190010738 TolR protein; Region: tolR; TIGR02801 509190010739 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 509190010740 Ca2+ binding site [ion binding]; other site 509190010741 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 509190010742 Ca2+ binding site [ion binding]; other site 509190010743 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 509190010744 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 509190010745 P-loop, Walker A motif; other site 509190010746 Base recognition motif; other site 509190010747 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 509190010748 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 509190010749 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 509190010750 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 509190010751 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 509190010752 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 509190010753 GTPase CgtA; Reviewed; Region: obgE; PRK12299 509190010754 GTP1/OBG; Region: GTP1_OBG; pfam01018 509190010755 Obg GTPase; Region: Obg; cd01898 509190010756 G1 box; other site 509190010757 GTP/Mg2+ binding site [chemical binding]; other site 509190010758 Switch I region; other site 509190010759 G2 box; other site 509190010760 G3 box; other site 509190010761 Switch II region; other site 509190010762 G4 box; other site 509190010763 G5 box; other site 509190010764 gamma-glutamyl kinase; Provisional; Region: PRK05429 509190010765 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 509190010766 nucleotide binding site [chemical binding]; other site 509190010767 homotetrameric interface [polypeptide binding]; other site 509190010768 putative phosphate binding site [ion binding]; other site 509190010769 putative allosteric binding site; other site 509190010770 PUA domain; Region: PUA; pfam01472 509190010771 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 509190010772 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 509190010773 putative active site [active] 509190010774 Zn binding site [ion binding]; other site 509190010775 MAPEG family; Region: MAPEG; cl09190 509190010776 peptidase PmbA; Provisional; Region: PRK11040 509190010777 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 509190010778 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 509190010779 active site 509190010780 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 509190010781 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 509190010782 Putative phosphatase (DUF442); Region: DUF442; cl17385 509190010783 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 509190010784 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 509190010785 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 509190010786 Walker A/P-loop; other site 509190010787 ATP binding site [chemical binding]; other site 509190010788 Q-loop/lid; other site 509190010789 ABC transporter signature motif; other site 509190010790 Walker B; other site 509190010791 D-loop; other site 509190010792 H-loop/switch region; other site 509190010793 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 509190010794 putative acyl-acceptor binding pocket; other site 509190010795 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 509190010796 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 509190010797 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 509190010798 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 509190010799 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 509190010800 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 509190010801 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 509190010802 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 509190010803 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 509190010804 active site 509190010805 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 509190010806 putative active site [active] 509190010807 ATP binding site [chemical binding]; other site 509190010808 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 509190010809 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 509190010810 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 509190010811 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 509190010812 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 509190010813 LytTr DNA-binding domain; Region: LytTR; smart00850 509190010814 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 509190010815 PAS domain; Region: PAS; smart00091 509190010816 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 509190010817 putative active site [active] 509190010818 heme pocket [chemical binding]; other site 509190010819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190010820 dimer interface [polypeptide binding]; other site 509190010821 phosphorylation site [posttranslational modification] 509190010822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190010823 ATP binding site [chemical binding]; other site 509190010824 Mg2+ binding site [ion binding]; other site 509190010825 G-X-G motif; other site 509190010826 Response regulator receiver domain; Region: Response_reg; pfam00072 509190010827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190010828 active site 509190010829 phosphorylation site [posttranslational modification] 509190010830 intermolecular recognition site; other site 509190010831 dimerization interface [polypeptide binding]; other site 509190010832 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 509190010833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190010834 active site 509190010835 phosphorylation site [posttranslational modification] 509190010836 intermolecular recognition site; other site 509190010837 dimerization interface [polypeptide binding]; other site 509190010838 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509190010839 DNA binding site [nucleotide binding] 509190010840 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 509190010841 PhoU domain; Region: PhoU; pfam01895 509190010842 PhoU domain; Region: PhoU; pfam01895 509190010843 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 509190010844 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 509190010845 Walker A/P-loop; other site 509190010846 ATP binding site [chemical binding]; other site 509190010847 Q-loop/lid; other site 509190010848 ABC transporter signature motif; other site 509190010849 Walker B; other site 509190010850 D-loop; other site 509190010851 H-loop/switch region; other site 509190010852 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 509190010853 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 509190010854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509190010855 dimer interface [polypeptide binding]; other site 509190010856 conserved gate region; other site 509190010857 putative PBP binding loops; other site 509190010858 ABC-ATPase subunit interface; other site 509190010859 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 509190010860 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 509190010861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509190010862 dimer interface [polypeptide binding]; other site 509190010863 conserved gate region; other site 509190010864 putative PBP binding loops; other site 509190010865 ABC-ATPase subunit interface; other site 509190010866 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 509190010867 PAS domain; Region: PAS_8; pfam13188 509190010868 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190010869 dimer interface [polypeptide binding]; other site 509190010870 phosphorylation site [posttranslational modification] 509190010871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190010872 ATP binding site [chemical binding]; other site 509190010873 Mg2+ binding site [ion binding]; other site 509190010874 G-X-G motif; other site 509190010875 Autotransporter beta-domain; Region: Autotransporter; smart00869 509190010876 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 509190010877 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 509190010878 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 509190010879 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 509190010880 hypothetical protein; Provisional; Region: PRK13559 509190010881 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190010882 putative active site [active] 509190010883 heme pocket [chemical binding]; other site 509190010884 Histidine kinase; Region: HisKA_2; pfam07568 509190010885 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190010886 ATP binding site [chemical binding]; other site 509190010887 Mg2+ binding site [ion binding]; other site 509190010888 G-X-G motif; other site 509190010889 response regulator; Provisional; Region: PRK13435 509190010890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190010891 active site 509190010892 phosphorylation site [posttranslational modification] 509190010893 intermolecular recognition site; other site 509190010894 dimerization interface [polypeptide binding]; other site 509190010895 Uncharacterized conserved protein [Function unknown]; Region: COG4095 509190010896 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 509190010897 feedback inhibition sensing region; other site 509190010898 homohexameric interface [polypeptide binding]; other site 509190010899 nucleotide binding site [chemical binding]; other site 509190010900 N-acetyl-L-glutamate binding site [chemical binding]; other site 509190010901 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 509190010902 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509190010903 motif II; other site 509190010904 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 509190010905 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 509190010906 trimer interface [polypeptide binding]; other site 509190010907 active site 509190010908 substrate binding site [chemical binding]; other site 509190010909 CoA binding site [chemical binding]; other site 509190010910 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 509190010911 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 509190010912 putative active site [active] 509190010913 substrate binding site [chemical binding]; other site 509190010914 putative cosubstrate binding site; other site 509190010915 catalytic site [active] 509190010916 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 509190010917 substrate binding site [chemical binding]; other site 509190010918 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 509190010919 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 509190010920 dimerization interface 3.5A [polypeptide binding]; other site 509190010921 active site 509190010922 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 509190010923 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 509190010924 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 509190010925 glutaminase; Provisional; Region: PRK00971 509190010926 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 509190010927 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 509190010928 metal binding site [ion binding]; metal-binding site 509190010929 dimer interface [polypeptide binding]; other site 509190010930 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 509190010931 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 509190010932 putative C-terminal domain interface [polypeptide binding]; other site 509190010933 putative GSH binding site (G-site) [chemical binding]; other site 509190010934 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509190010935 putative dimer interface [polypeptide binding]; other site 509190010936 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 509190010937 N-terminal domain interface [polypeptide binding]; other site 509190010938 substrate binding pocket (H-site) [chemical binding]; other site 509190010939 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 509190010940 active site 509190010941 catalytic residues [active] 509190010942 metal binding site [ion binding]; metal-binding site 509190010943 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 509190010944 RmuC family; Region: RmuC; pfam02646 509190010945 recombination protein RecR; Reviewed; Region: recR; PRK00076 509190010946 RecR protein; Region: RecR; pfam02132 509190010947 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 509190010948 putative active site [active] 509190010949 putative metal-binding site [ion binding]; other site 509190010950 tetramer interface [polypeptide binding]; other site 509190010951 hypothetical protein; Provisional; Region: PRK14625 509190010952 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 509190010953 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509190010954 Walker A motif; other site 509190010955 ATP binding site [chemical binding]; other site 509190010956 Walker B motif; other site 509190010957 arginine finger; other site 509190010958 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 509190010959 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 509190010960 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 509190010961 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 509190010962 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 509190010963 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 509190010964 putative NADH binding site [chemical binding]; other site 509190010965 putative active site [active] 509190010966 nudix motif; other site 509190010967 putative metal binding site [ion binding]; other site 509190010968 AMP nucleosidase; Provisional; Region: PRK08292 509190010969 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 509190010970 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 509190010971 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 509190010972 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 509190010973 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 509190010974 dimer interface [polypeptide binding]; other site 509190010975 putative radical transfer pathway; other site 509190010976 diiron center [ion binding]; other site 509190010977 tyrosyl radical; other site 509190010978 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509190010979 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 509190010980 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 509190010981 N-terminal domain interface [polypeptide binding]; other site 509190010982 dimer interface [polypeptide binding]; other site 509190010983 substrate binding pocket (H-site) [chemical binding]; other site 509190010984 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 509190010985 Helix-turn-helix domain; Region: HTH_18; pfam12833 509190010986 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509190010987 CAAX protease self-immunity; Region: Abi; pfam02517 509190010988 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 509190010989 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 509190010990 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 509190010991 Class I ribonucleotide reductase; Region: RNR_I; cd01679 509190010992 active site 509190010993 dimer interface [polypeptide binding]; other site 509190010994 catalytic residues [active] 509190010995 effector binding site; other site 509190010996 R2 peptide binding site; other site 509190010997 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; cl01409 509190010998 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190010999 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190011000 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 509190011001 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 509190011002 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509190011003 catalytic residue [active] 509190011004 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 509190011005 nucleophile elbow; other site 509190011006 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 509190011007 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 509190011008 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 509190011009 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 509190011010 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 509190011011 ligand binding site [chemical binding]; other site 509190011012 Methyltransferase domain; Region: Methyltransf_23; pfam13489 509190011013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190011014 S-adenosylmethionine binding site [chemical binding]; other site 509190011015 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 509190011016 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 509190011017 DNA binding residues [nucleotide binding] 509190011018 putative dimer interface [polypeptide binding]; other site 509190011019 putative metal binding residues [ion binding]; other site 509190011020 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 509190011021 TrkA-N domain; Region: TrkA_N; pfam02254 509190011022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509190011023 non-specific DNA binding site [nucleotide binding]; other site 509190011024 salt bridge; other site 509190011025 sequence-specific DNA binding site [nucleotide binding]; other site 509190011026 putative cation:proton antiport protein; Provisional; Region: PRK10669 509190011027 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 509190011028 TrkA-N domain; Region: TrkA_N; pfam02254 509190011029 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 509190011030 dimer interaction site [polypeptide binding]; other site 509190011031 substrate-binding tunnel; other site 509190011032 active site 509190011033 catalytic site [active] 509190011034 substrate binding site [chemical binding]; other site 509190011035 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 509190011036 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 509190011037 active site 509190011038 Zn binding site [ion binding]; other site 509190011039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190011040 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509190011041 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 509190011042 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 509190011043 HlyD family secretion protein; Region: HlyD_3; pfam13437 509190011044 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 509190011045 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 509190011046 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509190011047 N-terminal plug; other site 509190011048 ligand-binding site [chemical binding]; other site 509190011049 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 509190011050 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 509190011051 active site 509190011052 motif 2; other site 509190011053 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 509190011054 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 509190011055 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 509190011056 dimer interface [polypeptide binding]; other site 509190011057 motif 1; other site 509190011058 motif 2; other site 509190011059 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 509190011060 motif 3; other site 509190011061 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 509190011062 anticodon binding site; other site 509190011063 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 509190011064 GIY-YIG motif/motif A; other site 509190011065 putative active site [active] 509190011066 putative metal binding site [ion binding]; other site 509190011067 DoxX-like family; Region: DoxX_2; pfam13564 509190011068 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190011069 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190011070 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 509190011071 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 509190011072 active site 509190011073 dimer interface [polypeptide binding]; other site 509190011074 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 509190011075 dimer interface [polypeptide binding]; other site 509190011076 active site 509190011077 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 509190011078 putative catalytic residue [active] 509190011079 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 509190011080 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 509190011081 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 509190011082 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 509190011083 DsbD alpha interface [polypeptide binding]; other site 509190011084 catalytic residues [active] 509190011085 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 509190011086 active site 2 [active] 509190011087 active site 1 [active] 509190011088 SapC; Region: SapC; pfam07277 509190011089 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509190011090 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190011091 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 509190011092 active site 509190011093 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 509190011094 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 509190011095 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 509190011096 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 509190011097 putative active site; other site 509190011098 catalytic triad [active] 509190011099 putative dimer interface [polypeptide binding]; other site 509190011100 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 509190011101 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 509190011102 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 509190011103 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509190011104 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 509190011105 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 509190011106 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 509190011107 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 509190011108 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 509190011109 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 509190011110 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 509190011111 TrkA-N domain; Region: TrkA_N; pfam02254 509190011112 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 509190011113 Fatty acid desaturase; Region: FA_desaturase; pfam00487 509190011114 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 509190011115 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 509190011116 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 509190011117 ligand binding site [chemical binding]; other site 509190011118 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 509190011119 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 509190011120 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 509190011121 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 509190011122 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 509190011123 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 509190011124 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 509190011125 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 509190011126 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 509190011127 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190011128 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 509190011129 dimerization interface [polypeptide binding]; other site 509190011130 substrate binding pocket [chemical binding]; other site 509190011131 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 509190011132 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 509190011133 substrate binding site [chemical binding]; other site 509190011134 ligand binding site [chemical binding]; other site 509190011135 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 509190011136 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 509190011137 substrate binding site [chemical binding]; other site 509190011138 Uncharacterized conserved protein [Function unknown]; Region: COG1359 509190011139 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 509190011140 tartrate dehydrogenase; Region: TTC; TIGR02089 509190011141 CHASE3 domain; Region: CHASE3; cl05000 509190011142 HAMP domain; Region: HAMP; pfam00672 509190011143 dimerization interface [polypeptide binding]; other site 509190011144 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 509190011145 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190011146 dimer interface [polypeptide binding]; other site 509190011147 putative CheW interface [polypeptide binding]; other site 509190011148 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 509190011149 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 509190011150 dimer interface [polypeptide binding]; other site 509190011151 acyl-activating enzyme (AAE) consensus motif; other site 509190011152 putative active site [active] 509190011153 AMP binding site [chemical binding]; other site 509190011154 putative CoA binding site [chemical binding]; other site 509190011155 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509190011156 Coenzyme A binding pocket [chemical binding]; other site 509190011157 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 509190011158 hydrophobic ligand binding site; other site 509190011159 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 509190011160 CoenzymeA binding site [chemical binding]; other site 509190011161 subunit interaction site [polypeptide binding]; other site 509190011162 PHB binding site; other site 509190011163 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 509190011164 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 509190011165 active site 509190011166 catalytic tetrad [active] 509190011167 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 509190011168 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190011169 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 509190011170 putative effector binding pocket; other site 509190011171 putative dimerization interface [polypeptide binding]; other site 509190011172 elongation factor P; Validated; Region: PRK00529 509190011173 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 509190011174 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 509190011175 RNA binding site [nucleotide binding]; other site 509190011176 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 509190011177 RNA binding site [nucleotide binding]; other site 509190011178 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 509190011179 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 509190011180 motif 1; other site 509190011181 dimer interface [polypeptide binding]; other site 509190011182 active site 509190011183 motif 2; other site 509190011184 motif 3; other site 509190011185 tellurite resistance protein terB; Region: terB; cd07176 509190011186 putative metal binding site [ion binding]; other site 509190011187 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 509190011188 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 509190011189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 509190011190 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 509190011191 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509190011192 Walker A/P-loop; other site 509190011193 ATP binding site [chemical binding]; other site 509190011194 Q-loop/lid; other site 509190011195 ABC transporter signature motif; other site 509190011196 Walker B; other site 509190011197 D-loop; other site 509190011198 H-loop/switch region; other site 509190011199 Purine nucleoside permease (NUP); Region: NUP; cl17832 509190011200 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190011201 putative active site [active] 509190011202 PAS fold; Region: PAS_3; pfam08447 509190011203 heme pocket [chemical binding]; other site 509190011204 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190011205 dimer interface [polypeptide binding]; other site 509190011206 phosphorylation site [posttranslational modification] 509190011207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190011208 ATP binding site [chemical binding]; other site 509190011209 Mg2+ binding site [ion binding]; other site 509190011210 G-X-G motif; other site 509190011211 Response regulator receiver domain; Region: Response_reg; pfam00072 509190011212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190011213 active site 509190011214 phosphorylation site [posttranslational modification] 509190011215 intermolecular recognition site; other site 509190011216 dimerization interface [polypeptide binding]; other site 509190011217 circadian clock protein KaiC; Reviewed; Region: PRK09302 509190011218 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 509190011219 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 509190011220 Walker A motif; other site 509190011221 Walker A motif; other site 509190011222 ATP binding site [chemical binding]; other site 509190011223 Walker B motif; other site 509190011224 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 509190011225 Walker A motif; other site 509190011226 ATP binding site [chemical binding]; other site 509190011227 Walker B motif; other site 509190011228 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 509190011229 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 509190011230 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 509190011231 Glucokinase; Region: Glucokinase; cl17310 509190011232 glucokinase, proteobacterial type; Region: glk; TIGR00749 509190011233 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 509190011234 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 509190011235 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 509190011236 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190011237 dimer interface [polypeptide binding]; other site 509190011238 phosphorylation site [posttranslational modification] 509190011239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190011240 ATP binding site [chemical binding]; other site 509190011241 Mg2+ binding site [ion binding]; other site 509190011242 G-X-G motif; other site 509190011243 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 509190011244 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 509190011245 SLBB domain; Region: SLBB; pfam10531 509190011246 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 509190011247 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 509190011248 active site 509190011249 metal binding site [ion binding]; metal-binding site 509190011250 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 509190011251 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 509190011252 O-Antigen ligase; Region: Wzy_C; pfam04932 509190011253 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 509190011254 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 509190011255 Chain length determinant protein; Region: Wzz; pfam02706 509190011256 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 509190011257 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 509190011258 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190011259 putative CheW interface [polypeptide binding]; other site 509190011260 recombination protein F; Reviewed; Region: recF; PRK00064 509190011261 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 509190011262 Walker A/P-loop; other site 509190011263 ATP binding site [chemical binding]; other site 509190011264 Q-loop/lid; other site 509190011265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509190011266 ABC transporter signature motif; other site 509190011267 Walker B; other site 509190011268 D-loop; other site 509190011269 H-loop/switch region; other site 509190011270 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 509190011271 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 509190011272 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 509190011273 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 509190011274 dimer interface [polypeptide binding]; other site 509190011275 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 509190011276 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 509190011277 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 509190011278 ribonuclease PH; Reviewed; Region: rph; PRK00173 509190011279 Ribonuclease PH; Region: RNase_PH_bact; cd11362 509190011280 hexamer interface [polypeptide binding]; other site 509190011281 active site 509190011282 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 509190011283 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 509190011284 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 509190011285 protein binding site [polypeptide binding]; other site 509190011286 Predicted transcriptional regulator [Transcription]; Region: COG3655 509190011287 sequence-specific DNA binding site [nucleotide binding]; other site 509190011288 salt bridge; other site 509190011289 putative glutathione S-transferase; Provisional; Region: PRK10357 509190011290 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 509190011291 putative C-terminal domain interface [polypeptide binding]; other site 509190011292 putative GSH binding site (G-site) [chemical binding]; other site 509190011293 putative dimer interface [polypeptide binding]; other site 509190011294 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 509190011295 N-terminal domain interface [polypeptide binding]; other site 509190011296 dimer interface [polypeptide binding]; other site 509190011297 substrate binding pocket (H-site) [chemical binding]; other site 509190011298 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 509190011299 active site 509190011300 dimerization interface [polypeptide binding]; other site 509190011301 Predicted methyltransferases [General function prediction only]; Region: COG0313 509190011302 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 509190011303 putative SAM binding site [chemical binding]; other site 509190011304 putative homodimer interface [polypeptide binding]; other site 509190011305 hypothetical protein; Reviewed; Region: PRK12497 509190011306 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 509190011307 glutathione synthetase; Provisional; Region: PRK05246 509190011308 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 509190011309 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 509190011310 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 509190011311 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 509190011312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509190011313 Walker A motif; other site 509190011314 ATP binding site [chemical binding]; other site 509190011315 Walker B motif; other site 509190011316 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 509190011317 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190011318 dimer interface [polypeptide binding]; other site 509190011319 phosphorylation site [posttranslational modification] 509190011320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190011321 ATP binding site [chemical binding]; other site 509190011322 Mg2+ binding site [ion binding]; other site 509190011323 G-X-G motif; other site 509190011324 Response regulator receiver domain; Region: Response_reg; pfam00072 509190011325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190011326 active site 509190011327 phosphorylation site [posttranslational modification] 509190011328 intermolecular recognition site; other site 509190011329 dimerization interface [polypeptide binding]; other site 509190011330 muropeptide transporter; Validated; Region: ampG; cl17669 509190011331 muropeptide transporter; Validated; Region: ampG; cl17669 509190011332 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 509190011333 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 509190011334 Predicted membrane protein [Function unknown]; Region: COG3766 509190011335 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 509190011336 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 509190011337 putative hydrophobic ligand binding site [chemical binding]; other site 509190011338 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509190011339 dimerization interface [polypeptide binding]; other site 509190011340 putative DNA binding site [nucleotide binding]; other site 509190011341 putative Zn2+ binding site [ion binding]; other site 509190011342 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 509190011343 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509190011344 FeS/SAM binding site; other site 509190011345 classical (c) SDRs; Region: SDR_c; cd05233 509190011346 NAD(P) binding site [chemical binding]; other site 509190011347 active site 509190011348 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 509190011349 active site 509190011350 Protein of unknown function (DUF3553); Region: DUF3553; pfam12073 509190011351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 509190011352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190011353 Response regulator receiver domain; Region: Response_reg; pfam00072 509190011354 active site 509190011355 phosphorylation site [posttranslational modification] 509190011356 intermolecular recognition site; other site 509190011357 dimerization interface [polypeptide binding]; other site 509190011358 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 509190011359 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 509190011360 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 509190011361 Entericidin EcnA/B family; Region: Entericidin; cl02322 509190011362 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 509190011363 Histidine kinase; Region: HisKA_2; pfam07568 509190011364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190011365 ATP binding site [chemical binding]; other site 509190011366 Mg2+ binding site [ion binding]; other site 509190011367 G-X-G motif; other site 509190011368 RNA polymerase sigma factor; Provisional; Region: PRK12547 509190011369 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509190011370 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509190011371 DNA binding residues [nucleotide binding] 509190011372 two-component response regulator; Provisional; Region: PRK09191 509190011373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190011374 active site 509190011375 phosphorylation site [posttranslational modification] 509190011376 intermolecular recognition site; other site 509190011377 dimerization interface [polypeptide binding]; other site 509190011378 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 509190011379 ligand binding site [chemical binding]; other site 509190011380 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 509190011381 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 509190011382 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 509190011383 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 509190011384 active site 509190011385 metal binding site [ion binding]; metal-binding site 509190011386 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 509190011387 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 509190011388 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 509190011389 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 509190011390 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190011391 PAS fold; Region: PAS_3; pfam08447 509190011392 putative active site [active] 509190011393 heme pocket [chemical binding]; other site 509190011394 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 509190011395 HWE histidine kinase; Region: HWE_HK; pfam07536 509190011396 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 509190011397 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509190011398 Coenzyme A binding pocket [chemical binding]; other site 509190011399 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 509190011400 CoA-transferase family III; Region: CoA_transf_3; pfam02515 509190011401 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 509190011402 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 509190011403 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 509190011404 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 509190011405 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 509190011406 Zn binding site [ion binding]; other site 509190011407 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 509190011408 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 509190011409 Walker A/P-loop; other site 509190011410 ATP binding site [chemical binding]; other site 509190011411 Q-loop/lid; other site 509190011412 ABC transporter signature motif; other site 509190011413 Walker B; other site 509190011414 D-loop; other site 509190011415 H-loop/switch region; other site 509190011416 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 509190011417 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 509190011418 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 509190011419 C-terminal domain interface [polypeptide binding]; other site 509190011420 GSH binding site (G-site) [chemical binding]; other site 509190011421 putative dimer interface [polypeptide binding]; other site 509190011422 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 509190011423 dimer interface [polypeptide binding]; other site 509190011424 N-terminal domain interface [polypeptide binding]; other site 509190011425 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 509190011426 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 509190011427 active site clefts [active] 509190011428 zinc binding site [ion binding]; other site 509190011429 dimer interface [polypeptide binding]; other site 509190011430 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 509190011431 active site clefts [active] 509190011432 zinc binding site [ion binding]; other site 509190011433 dimer interface [polypeptide binding]; other site 509190011434 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 509190011435 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509190011436 putative DNA binding site [nucleotide binding]; other site 509190011437 putative Zn2+ binding site [ion binding]; other site 509190011438 AsnC family; Region: AsnC_trans_reg; pfam01037 509190011439 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 509190011440 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 509190011441 hexamer interface [polypeptide binding]; other site 509190011442 ligand binding site [chemical binding]; other site 509190011443 putative active site [active] 509190011444 NAD(P) binding site [chemical binding]; other site 509190011445 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 509190011446 ligand binding site; other site 509190011447 bifunctional regulator KidO; Provisional; Region: PRK14863 509190011448 active site 509190011449 catalytic tetrad [active] 509190011450 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 509190011451 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 509190011452 XdhC Rossmann domain; Region: XdhC_C; pfam13478 509190011453 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 509190011454 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 509190011455 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 509190011456 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 509190011457 NAD(P) binding site [chemical binding]; other site 509190011458 catalytic residues [active] 509190011459 acetyl-CoA synthetase; Provisional; Region: PRK00174 509190011460 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 509190011461 active site 509190011462 CoA binding site [chemical binding]; other site 509190011463 acyl-activating enzyme (AAE) consensus motif; other site 509190011464 AMP binding site [chemical binding]; other site 509190011465 acetate binding site [chemical binding]; other site 509190011466 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 509190011467 hydrophobic ligand binding site; other site 509190011468 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 509190011469 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 509190011470 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509190011471 putative active site [active] 509190011472 heme pocket [chemical binding]; other site 509190011473 GAF domain; Region: GAF; pfam01590 509190011474 Phytochrome region; Region: PHY; pfam00360 509190011475 HWE histidine kinase; Region: HWE_HK; pfam07536 509190011476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190011477 active site 509190011478 phosphorylation site [posttranslational modification] 509190011479 intermolecular recognition site; other site 509190011480 dimerization interface [polypeptide binding]; other site 509190011481 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 509190011482 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 509190011483 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 509190011484 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 509190011485 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 509190011486 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 509190011487 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 509190011488 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 509190011489 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 509190011490 IHF dimer interface [polypeptide binding]; other site 509190011491 IHF - DNA interface [nucleotide binding]; other site 509190011492 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 509190011493 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 509190011494 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 509190011495 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 509190011496 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 509190011497 RNA binding site [nucleotide binding]; other site 509190011498 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 509190011499 RNA binding site [nucleotide binding]; other site 509190011500 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 509190011501 RNA binding site [nucleotide binding]; other site 509190011502 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 509190011503 RNA binding site [nucleotide binding]; other site 509190011504 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 509190011505 RNA binding site [nucleotide binding]; other site 509190011506 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 509190011507 RNA binding site [nucleotide binding]; other site 509190011508 cytidylate kinase; Provisional; Region: cmk; PRK00023 509190011509 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 509190011510 CMP-binding site; other site 509190011511 The sites determining sugar specificity; other site 509190011512 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 509190011513 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 509190011514 hinge; other site 509190011515 active site 509190011516 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 509190011517 TIGR02300 family protein; Region: FYDLN_acid 509190011518 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 509190011519 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 509190011520 putative dimer interface [polypeptide binding]; other site 509190011521 Protein of unknown function (DUF1150); Region: DUF1150; cl11577 509190011522 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 509190011523 active site 509190011524 phosphorylation site [posttranslational modification] 509190011525 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 509190011526 30S subunit binding site; other site 509190011527 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 509190011528 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 509190011529 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 509190011530 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 509190011531 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 509190011532 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 509190011533 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 509190011534 Walker A/P-loop; other site 509190011535 ATP binding site [chemical binding]; other site 509190011536 Q-loop/lid; other site 509190011537 ABC transporter signature motif; other site 509190011538 Walker B; other site 509190011539 D-loop; other site 509190011540 H-loop/switch region; other site 509190011541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 509190011542 OstA-like protein; Region: OstA; pfam03968 509190011543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 509190011544 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 509190011545 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 509190011546 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 509190011547 catalytic site [active] 509190011548 putative active site [active] 509190011549 putative substrate binding site [chemical binding]; other site 509190011550 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 509190011551 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 509190011552 putative NAD(P) binding site [chemical binding]; other site 509190011553 active site 509190011554 Undecaprenyl pyrophosphate phosphatase [Lipid transport and metabolism]; Region: BacA; COG1968 509190011555 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 509190011556 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 509190011557 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 509190011558 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 509190011559 active site 509190011560 dimer interface [polypeptide binding]; other site 509190011561 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 509190011562 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 509190011563 active site 509190011564 FMN binding site [chemical binding]; other site 509190011565 substrate binding site [chemical binding]; other site 509190011566 3Fe-4S cluster binding site [ion binding]; other site 509190011567 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 509190011568 domain interface; other site 509190011569 DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120 509190011570 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 509190011571 active site 509190011572 DNA binding site [nucleotide binding] 509190011573 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 509190011574 DNA binding site [nucleotide binding] 509190011575 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 509190011576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190011577 putative substrate translocation pore; other site 509190011578 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 509190011579 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 509190011580 inhibitor-cofactor binding pocket; inhibition site 509190011581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190011582 catalytic residue [active] 509190011583 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 509190011584 Mechanosensitive ion channel; Region: MS_channel; pfam00924 509190011585 MarR family; Region: MarR_2; pfam12802 509190011586 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 509190011587 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 509190011588 active site 509190011589 intersubunit interactions; other site 509190011590 catalytic residue [active] 509190011591 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 509190011592 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 509190011593 NADP binding site [chemical binding]; other site 509190011594 active site 509190011595 putative substrate binding site [chemical binding]; other site 509190011596 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 509190011597 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509190011598 active site 509190011599 motif I; other site 509190011600 motif II; other site 509190011601 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 509190011602 dimerization interface [polypeptide binding]; other site 509190011603 putative active cleft [active] 509190011604 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 509190011605 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 509190011606 Substrate binding site; other site 509190011607 NAD synthetase; Reviewed; Region: nadE; PRK02628 509190011608 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 509190011609 multimer interface [polypeptide binding]; other site 509190011610 active site 509190011611 catalytic triad [active] 509190011612 protein interface 1 [polypeptide binding]; other site 509190011613 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 509190011614 homodimer interface [polypeptide binding]; other site 509190011615 NAD binding pocket [chemical binding]; other site 509190011616 ATP binding pocket [chemical binding]; other site 509190011617 Mg binding site [ion binding]; other site 509190011618 active-site loop [active] 509190011619 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 509190011620 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 509190011621 TPP-binding site [chemical binding]; other site 509190011622 dimer interface [polypeptide binding]; other site 509190011623 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 509190011624 PYR/PP interface [polypeptide binding]; other site 509190011625 dimer interface [polypeptide binding]; other site 509190011626 TPP binding site [chemical binding]; other site 509190011627 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 509190011628 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 509190011629 YGGT family; Region: YGGT; pfam02325 509190011630 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 509190011631 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509190011632 dimer interface [polypeptide binding]; other site 509190011633 phosphorylation site [posttranslational modification] 509190011634 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 509190011635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509190011636 ATP binding site [chemical binding]; other site 509190011637 Mg2+ binding site [ion binding]; other site 509190011638 G-X-G motif; other site 509190011639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190011640 active site 509190011641 phosphorylation site [posttranslational modification] 509190011642 intermolecular recognition site; other site 509190011643 dimerization interface [polypeptide binding]; other site 509190011644 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 509190011645 additional DNA contacts [nucleotide binding]; other site 509190011646 mismatch recognition site; other site 509190011647 active site 509190011648 zinc binding site [ion binding]; other site 509190011649 DNA intercalation site [nucleotide binding]; other site 509190011650 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 509190011651 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 509190011652 dimer interface [polypeptide binding]; other site 509190011653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190011654 catalytic residue [active] 509190011655 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 509190011656 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 509190011657 cofactor binding site; other site 509190011658 DNA binding site [nucleotide binding] 509190011659 substrate interaction site [chemical binding]; other site 509190011660 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 509190011661 Predicted membrane protein [Function unknown]; Region: COG3650 509190011662 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 509190011663 Beta-lactamase; Region: Beta-lactamase; pfam00144 509190011664 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 509190011665 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 509190011666 substrate binding site; other site 509190011667 tetramer interface; other site 509190011668 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 509190011669 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 509190011670 NADP binding site [chemical binding]; other site 509190011671 active site 509190011672 putative substrate binding site [chemical binding]; other site 509190011673 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 509190011674 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 509190011675 NAD binding site [chemical binding]; other site 509190011676 substrate binding site [chemical binding]; other site 509190011677 homodimer interface [polypeptide binding]; other site 509190011678 active site 509190011679 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 509190011680 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 509190011681 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 509190011682 putative active site [active] 509190011683 putative substrate binding site [chemical binding]; other site 509190011684 putative cosubstrate binding site; other site 509190011685 catalytic site [active] 509190011686 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 509190011687 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 509190011688 Probable Catalytic site; other site 509190011689 metal-binding site 509190011690 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 509190011691 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 509190011692 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509190011693 threonine dehydratase; Provisional; Region: PRK07334 509190011694 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 509190011695 tetramer interface [polypeptide binding]; other site 509190011696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509190011697 catalytic residue [active] 509190011698 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 509190011699 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 509190011700 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 509190011701 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 509190011702 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 509190011703 active site 509190011704 tetramer interface; other site 509190011705 epoxyqueuosine reductase; Region: TIGR00276 509190011706 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 509190011707 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509190011708 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 509190011709 C-terminal domain interface [polypeptide binding]; other site 509190011710 GSH binding site (G-site) [chemical binding]; other site 509190011711 dimer interface [polypeptide binding]; other site 509190011712 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 509190011713 N-terminal domain interface [polypeptide binding]; other site 509190011714 dimer interface [polypeptide binding]; other site 509190011715 substrate binding pocket (H-site) [chemical binding]; other site 509190011716 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 509190011717 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 509190011718 putative ribose interaction site [chemical binding]; other site 509190011719 putative ADP binding site [chemical binding]; other site 509190011720 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 509190011721 active site 509190011722 nucleotide binding site [chemical binding]; other site 509190011723 HIGH motif; other site 509190011724 KMSKS motif; other site 509190011725 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 509190011726 Cation efflux family; Region: Cation_efflux; cl00316 509190011727 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 509190011728 dimer interface [polypeptide binding]; other site 509190011729 Citrate synthase; Region: Citrate_synt; pfam00285 509190011730 active site 509190011731 citrylCoA binding site [chemical binding]; other site 509190011732 oxalacetate/citrate binding site [chemical binding]; other site 509190011733 coenzyme A binding site [chemical binding]; other site 509190011734 catalytic triad [active] 509190011735 Helix-turn-helix domain; Region: HTH_17; pfam12728 509190011736 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 509190011737 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 509190011738 dimer interface [polypeptide binding]; other site 509190011739 active site 509190011740 oxalacetate/citrate binding site [chemical binding]; other site 509190011741 citrylCoA binding site [chemical binding]; other site 509190011742 coenzyme A binding site [chemical binding]; other site 509190011743 catalytic triad [active] 509190011744 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 509190011745 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 509190011746 CoenzymeA binding site [chemical binding]; other site 509190011747 subunit interaction site [polypeptide binding]; other site 509190011748 PHB binding site; other site 509190011749 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 509190011750 CoenzymeA binding site [chemical binding]; other site 509190011751 subunit interaction site [polypeptide binding]; other site 509190011752 PHB binding site; other site 509190011753 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 509190011754 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 509190011755 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 509190011756 putative active site [active] 509190011757 Zn binding site [ion binding]; other site 509190011758 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 509190011759 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 509190011760 active site 509190011761 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 509190011762 catalytic triad [active] 509190011763 dimer interface [polypeptide binding]; other site 509190011764 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 509190011765 active site triad [active] 509190011766 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 509190011767 dimer interface [polypeptide binding]; other site 509190011768 ADP-ribose binding site [chemical binding]; other site 509190011769 active site 509190011770 nudix motif; other site 509190011771 metal binding site [ion binding]; metal-binding site 509190011772 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 509190011773 RimM N-terminal domain; Region: RimM; pfam01782 509190011774 PRC-barrel domain; Region: PRC; pfam05239 509190011775 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 509190011776 signal recognition particle protein; Provisional; Region: PRK10867 509190011777 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 509190011778 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 509190011779 P loop; other site 509190011780 GTP binding site [chemical binding]; other site 509190011781 Signal peptide binding domain; Region: SRP_SPB; pfam02978 509190011782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3812 509190011783 FOG: CBS domain [General function prediction only]; Region: COG0517 509190011784 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 509190011785 malate dehydrogenase; Reviewed; Region: PRK06223 509190011786 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 509190011787 NAD(P) binding site [chemical binding]; other site 509190011788 dimer interface [polypeptide binding]; other site 509190011789 tetramer (dimer of dimers) interface [polypeptide binding]; other site 509190011790 substrate binding site [chemical binding]; other site 509190011791 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 509190011792 putative active site [active] 509190011793 putative catalytic site [active] 509190011794 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 509190011795 putative active site [active] 509190011796 putative catalytic site [active] 509190011797 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 509190011798 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 509190011799 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 509190011800 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 509190011801 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 509190011802 DNA binding site [nucleotide binding] 509190011803 catalytic residue [active] 509190011804 H2TH interface [polypeptide binding]; other site 509190011805 putative catalytic residues [active] 509190011806 turnover-facilitating residue; other site 509190011807 intercalation triad [nucleotide binding]; other site 509190011808 8OG recognition residue [nucleotide binding]; other site 509190011809 putative reading head residues; other site 509190011810 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 509190011811 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 509190011812 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 509190011813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509190011814 S-adenosylmethionine binding site [chemical binding]; other site 509190011815 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 509190011816 ABC1 family; Region: ABC1; cl17513 509190011817 Pyocin large subunit [General function prediction only]; Region: COG5529 509190011818 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 509190011819 Flavoprotein; Region: Flavoprotein; pfam02441 509190011820 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 509190011821 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 509190011822 trimer interface [polypeptide binding]; other site 509190011823 active site 509190011824 CHASE3 domain; Region: CHASE3; pfam05227 509190011825 HAMP domain; Region: HAMP; pfam00672 509190011826 dimerization interface [polypeptide binding]; other site 509190011827 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 509190011828 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190011829 dimer interface [polypeptide binding]; other site 509190011830 putative CheW interface [polypeptide binding]; other site 509190011831 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 509190011832 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 509190011833 HlyD family secretion protein; Region: HlyD_3; pfam13437 509190011834 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 509190011835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190011836 putative substrate translocation pore; other site 509190011837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509190011838 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509190011839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509190011840 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 509190011841 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 509190011842 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 509190011843 NAD binding site [chemical binding]; other site 509190011844 homotetramer interface [polypeptide binding]; other site 509190011845 homodimer interface [polypeptide binding]; other site 509190011846 substrate binding site [chemical binding]; other site 509190011847 active site 509190011848 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 509190011849 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 509190011850 dimer interface [polypeptide binding]; other site 509190011851 active site 509190011852 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 509190011853 active site 1 [active] 509190011854 dimer interface [polypeptide binding]; other site 509190011855 active site 2 [active] 509190011856 Bacterial SH3 domain; Region: SH3_4; pfam06347 509190011857 Bacterial SH3 domain; Region: SH3_4; pfam06347 509190011858 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 509190011859 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 509190011860 dimerization interface [polypeptide binding]; other site 509190011861 ligand binding site [chemical binding]; other site 509190011862 NADP binding site [chemical binding]; other site 509190011863 catalytic site [active] 509190011864 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 509190011865 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 509190011866 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 509190011867 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 509190011868 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 509190011869 active site 509190011870 catalytic tetrad [active] 509190011871 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 509190011872 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 509190011873 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 509190011874 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 509190011875 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 509190011876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509190011877 Walker A/P-loop; other site 509190011878 ATP binding site [chemical binding]; other site 509190011879 Q-loop/lid; other site 509190011880 ABC transporter signature motif; other site 509190011881 Walker B; other site 509190011882 D-loop; other site 509190011883 H-loop/switch region; other site 509190011884 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 509190011885 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 509190011886 Heme exporter protein D (CcmD); Region: CcmD; pfam04995 509190011887 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 509190011888 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 509190011889 catalytic residues [active] 509190011890 central insert; other site 509190011891 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 509190011892 MarR family; Region: MarR_2; pfam12802 509190011893 Intracellular septation protein A [Cell division and chromosome partitioning]; Region: COG2917 509190011894 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 509190011895 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 509190011896 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 509190011897 P loop; other site 509190011898 GTP binding site [chemical binding]; other site 509190011899 Predicted membrane protein [Function unknown]; Region: COG2860 509190011900 UPF0126 domain; Region: UPF0126; pfam03458 509190011901 UPF0126 domain; Region: UPF0126; pfam03458 509190011902 Uncharacterized conserved protein [Function unknown]; Region: COG3791 509190011903 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 509190011904 putative catalytic site [active] 509190011905 putative metal binding site [ion binding]; other site 509190011906 putative phosphate binding site [ion binding]; other site 509190011907 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 509190011908 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 509190011909 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 509190011910 Ion transport protein; Region: Ion_trans; pfam00520 509190011911 Ion channel; Region: Ion_trans_2; pfam07885 509190011912 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 509190011913 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509190011914 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 509190011915 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509190011916 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 509190011917 Predicted transcriptional regulators [Transcription]; Region: COG1695 509190011918 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 509190011919 VacJ like lipoprotein; Region: VacJ; cl01073 509190011920 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 509190011921 mce related protein; Region: MCE; pfam02470 509190011922 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 509190011923 Permease; Region: Permease; pfam02405 509190011924 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 509190011925 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 509190011926 Walker A/P-loop; other site 509190011927 ATP binding site [chemical binding]; other site 509190011928 Q-loop/lid; other site 509190011929 ABC transporter signature motif; other site 509190011930 Walker B; other site 509190011931 D-loop; other site 509190011932 H-loop/switch region; other site 509190011933 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 509190011934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509190011935 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 509190011936 dimerization interface [polypeptide binding]; other site 509190011937 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 509190011938 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 509190011939 hydrophobic ligand binding site; other site 509190011940 TraB family; Region: TraB; pfam01963 509190011941 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 509190011942 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 509190011943 active site 509190011944 Zn binding site [ion binding]; other site 509190011945 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 509190011946 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 509190011947 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 509190011948 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 509190011949 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 509190011950 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 509190011951 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 509190011952 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 509190011953 putative catalytic site [active] 509190011954 putative phosphate binding site [ion binding]; other site 509190011955 active site 509190011956 metal binding site A [ion binding]; metal-binding site 509190011957 DNA binding site [nucleotide binding] 509190011958 putative AP binding site [nucleotide binding]; other site 509190011959 putative metal binding site B [ion binding]; other site 509190011960 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 509190011961 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 509190011962 putative NAD(P) binding site [chemical binding]; other site 509190011963 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509190011964 salt bridge; other site 509190011965 non-specific DNA binding site [nucleotide binding]; other site 509190011966 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 509190011967 sequence-specific DNA binding site [nucleotide binding]; other site 509190011968 CHASE3 domain; Region: CHASE3; cl05000 509190011969 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 509190011970 dimerization interface [polypeptide binding]; other site 509190011971 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 509190011972 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509190011973 dimer interface [polypeptide binding]; other site 509190011974 putative CheW interface [polypeptide binding]; other site 509190011975 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 509190011976 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 509190011977 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 509190011978 active site 509190011979 catalytic site [active] 509190011980 substrate binding site [chemical binding]; other site 509190011981 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 509190011982 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 509190011983 CoA-binding site [chemical binding]; other site 509190011984 ATP-binding [chemical binding]; other site 509190011985 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 509190011986 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 509190011987 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 509190011988 shikimate binding site; other site 509190011989 NAD(P) binding site [chemical binding]; other site 509190011990 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 509190011991 putative active site [active] 509190011992 PEP synthetase regulatory protein; Provisional; Region: PRK05339 509190011993 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 509190011994 substrate binding site [chemical binding]; other site 509190011995 active site 509190011996 Ferrochelatase; Region: Ferrochelatase; pfam00762 509190011997 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 509190011998 C-terminal domain interface [polypeptide binding]; other site 509190011999 active site 509190012000 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 509190012001 active site 509190012002 N-terminal domain interface [polypeptide binding]; other site 509190012003 Predicted membrane protein [Function unknown]; Region: COG1981 509190012004 transcription termination factor Rho; Provisional; Region: rho; PRK09376 509190012005 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 509190012006 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 509190012007 RNA binding site [nucleotide binding]; other site 509190012008 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 509190012009 multimer interface [polypeptide binding]; other site 509190012010 Walker A motif; other site 509190012011 ATP binding site [chemical binding]; other site 509190012012 Walker B motif; other site 509190012013 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 509190012014 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 509190012015 NADP binding site [chemical binding]; other site 509190012016 dimer interface [polypeptide binding]; other site 509190012017 Dienelactone hydrolase family; Region: DLH; pfam01738 509190012018 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 509190012019 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 509190012020 trmE is a tRNA modification GTPase; Region: trmE; cd04164 509190012021 G1 box; other site 509190012022 GTP/Mg2+ binding site [chemical binding]; other site 509190012023 Switch I region; other site 509190012024 G2 box; other site 509190012025 Switch II region; other site 509190012026 G3 box; other site 509190012027 G4 box; other site 509190012028 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 509190012029 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 509190012030 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 509190012031 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 509190012032 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 509190012033 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 509190012034 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 509190012035 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 509190012036 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 509190012037 ParB-like nuclease domain; Region: ParBc; pfam02195 509190012038 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 509190012039 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5468 509190012040 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 509190012041 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 509190012042 HIGH motif; other site 509190012043 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 509190012044 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 509190012045 active site 509190012046 KMSKS motif; other site 509190012047 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 509190012048 tRNA binding surface [nucleotide binding]; other site 509190012049 Domain of unknown function (DUF3576); Region: DUF3576; pfam12100 509190012050 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 509190012051 thiamine phosphate binding site [chemical binding]; other site 509190012052 active site 509190012053 pyrophosphate binding site [ion binding]; other site 509190012054 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 509190012055 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 509190012056 catalytic residue [active] 509190012057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 509190012058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509190012059 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 509190012060 active site 509190012061 phosphorylation site [posttranslational modification] 509190012062 intermolecular recognition site; other site 509190012063 dimerization interface [polypeptide binding]; other site 509190012064 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509190012065 DNA binding site [nucleotide binding] 509190012066 Preprotein translocase subunit SecB [Intracellular trafficking and secretion]; Region: SecB; COG1952 509190012067 SecA binding site; other site 509190012068 Preprotein binding site; other site 509190012069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 509190012070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 509190012071 Smr domain; Region: Smr; pfam01713 509190012072 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 509190012073 metal binding site [ion binding]; metal-binding site 509190012074 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 509190012075 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 509190012076 substrate binding site [chemical binding]; other site 509190012077 glutamase interaction surface [polypeptide binding]; other site 509190012078 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 509190012079 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 509190012080 catalytic residues [active] 509190012081 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 509190012082 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 509190012083 putative active site [active] 509190012084 oxyanion strand; other site 509190012085 catalytic triad [active] 509190012086 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 509190012087 putative active site pocket [active] 509190012088 4-fold oligomerization interface [polypeptide binding]; other site 509190012089 metal binding residues [ion binding]; metal-binding site 509190012090 3-fold/trimer interface [polypeptide binding]; other site 509190012091 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 509190012092 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 509190012093 substrate binding site [chemical binding]; other site 509190012094 ATP binding site [chemical binding]; other site 509190012095 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 509190012096 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 509190012097 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 509190012098 minor groove reading motif; other site 509190012099 helix-hairpin-helix signature motif; other site 509190012100 substrate binding pocket [chemical binding]; other site 509190012101 active site 509190012102 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 509190012103 Integral membrane protein [Function unknown]; Region: COG5488 509190012104 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 509190012105 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 509190012106 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 509190012107 DNA binding site [nucleotide binding] 509190012108 active site 509190012109 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 509190012110 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509190012111 Walker A motif; other site 509190012112 ATP binding site [chemical binding]; other site 509190012113 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 509190012114 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 509190012115 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 509190012116 active site 509190012117 HslU subunit interaction site [polypeptide binding]; other site 509190012118 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 509190012119 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 509190012120 ATP binding site [chemical binding]; other site 509190012121 substrate interface [chemical binding]; other site 509190012122 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 509190012123 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 509190012124 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 509190012125 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 509190012126 apolar tunnel; other site 509190012127 heme binding site [chemical binding]; other site 509190012128 dimerization interface [polypeptide binding]; other site 509190012129 enoyl-CoA hydratase; Provisional; Region: PRK05862 509190012130 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509190012131 substrate binding site [chemical binding]; other site 509190012132 oxyanion hole (OAH) forming residues; other site 509190012133 trimer interface [polypeptide binding]; other site 509190012134 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239