-- dump date 20140619_030538 -- class Genbank::misc_feature -- table misc_feature_note -- id note 688270000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 688270000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 688270000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 688270000004 Walker A motif; other site 688270000005 ATP binding site [chemical binding]; other site 688270000006 Walker B motif; other site 688270000007 arginine finger; other site 688270000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 688270000009 DnaA box-binding interface [nucleotide binding]; other site 688270000010 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 688270000011 Low molecular weight phosphatase family; Region: LMWPc; cd00115 688270000012 active site 688270000013 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 688270000014 putative SAM binding site [chemical binding]; other site 688270000015 homodimer interface [polypeptide binding]; other site 688270000016 YceG-like family; Region: YceG; pfam02618 688270000017 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 688270000018 dimerization interface [polypeptide binding]; other site 688270000019 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 688270000020 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 688270000021 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 688270000022 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 688270000023 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 688270000024 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 688270000025 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 688270000026 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 688270000027 protein binding site [polypeptide binding]; other site 688270000028 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 688270000029 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 688270000030 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 688270000031 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 688270000032 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 688270000033 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 688270000034 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 688270000035 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270000036 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270000037 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 688270000038 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 688270000039 Domain of unknown function (DUF4294); Region: DUF4294; pfam14127 688270000040 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 688270000041 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 688270000042 oligomer interface [polypeptide binding]; other site 688270000043 active site 688270000044 metal binding site [ion binding]; metal-binding site 688270000045 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 688270000046 nudix motif; other site 688270000047 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 688270000048 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 688270000049 dimer interface [polypeptide binding]; other site 688270000050 motif 1; other site 688270000051 active site 688270000052 motif 2; other site 688270000053 motif 3; other site 688270000054 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 688270000055 anticodon binding site; other site 688270000056 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 688270000057 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270000058 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270000059 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 688270000060 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 688270000061 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 688270000062 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 688270000063 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 688270000064 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 688270000065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270000066 active site 688270000067 phosphorylation site [posttranslational modification] 688270000068 intermolecular recognition site; other site 688270000069 dimerization interface [polypeptide binding]; other site 688270000070 LytTr DNA-binding domain; Region: LytTR; smart00850 688270000071 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 688270000072 primosomal protein N' Region: priA; TIGR00595 688270000073 ATP binding site [chemical binding]; other site 688270000074 putative Mg++ binding site [ion binding]; other site 688270000075 helicase superfamily c-terminal domain; Region: HELICc; smart00490 688270000076 nucleotide binding region [chemical binding]; other site 688270000077 ATP-binding site [chemical binding]; other site 688270000078 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 688270000079 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 688270000080 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 688270000081 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 688270000082 dimerization interface [polypeptide binding]; other site 688270000083 active site 688270000084 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 688270000085 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 688270000086 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 688270000087 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 688270000088 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 688270000089 ligand binding site [chemical binding]; other site 688270000090 NAD binding site [chemical binding]; other site 688270000091 tetramer interface [polypeptide binding]; other site 688270000092 catalytic site [active] 688270000093 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 688270000094 L-serine binding site [chemical binding]; other site 688270000095 ACT domain interface; other site 688270000096 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 688270000097 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 688270000098 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 688270000099 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270000100 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 688270000101 DNA binding residues [nucleotide binding] 688270000102 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 688270000103 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 688270000104 active site 688270000105 dimerization interface [polypeptide binding]; other site 688270000106 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 688270000107 DEAD-like helicases superfamily; Region: DEXDc; smart00487 688270000108 ATP binding site [chemical binding]; other site 688270000109 Mg++ binding site [ion binding]; other site 688270000110 motif III; other site 688270000111 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 688270000112 nucleotide binding region [chemical binding]; other site 688270000113 ATP-binding site [chemical binding]; other site 688270000114 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 688270000115 RNA binding site [nucleotide binding]; other site 688270000116 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270000117 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 688270000118 active site 688270000119 catalytic site [active] 688270000120 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 688270000121 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 688270000122 putative active site [active] 688270000123 putative metal binding site [ion binding]; other site 688270000124 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 688270000125 NAD-dependent deacetylase; Provisional; Region: PRK00481 688270000126 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 688270000127 NAD+ binding site [chemical binding]; other site 688270000128 substrate binding site [chemical binding]; other site 688270000129 Zn binding site [ion binding]; other site 688270000130 SGT1 protein; Region: SGT1; pfam07093 688270000131 adenylosuccinate lyase; Provisional; Region: PRK09285 688270000132 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 688270000133 tetramer interface [polypeptide binding]; other site 688270000134 active site 688270000135 mechanosensitive channel MscS; Provisional; Region: PRK10334 688270000136 Conserved TM helix; Region: TM_helix; pfam05552 688270000137 Mechanosensitive ion channel; Region: MS_channel; pfam00924 688270000138 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 688270000139 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 688270000140 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 688270000141 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 688270000142 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 688270000143 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270000144 DNA binding residues [nucleotide binding] 688270000145 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 688270000146 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 688270000147 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 688270000148 Catalytic dyad [active] 688270000149 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 688270000150 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 688270000151 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270000152 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 688270000153 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 688270000154 putative ligand binding site [chemical binding]; other site 688270000155 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 688270000156 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 688270000157 ABC-ATPase subunit interface; other site 688270000158 dimer interface [polypeptide binding]; other site 688270000159 putative PBP binding regions; other site 688270000160 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 688270000161 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 688270000162 Walker A/P-loop; other site 688270000163 ATP binding site [chemical binding]; other site 688270000164 Q-loop/lid; other site 688270000165 ABC transporter signature motif; other site 688270000166 Walker B; other site 688270000167 D-loop; other site 688270000168 H-loop/switch region; other site 688270000169 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 688270000170 short chain dehydrogenase; Provisional; Region: PRK12937 688270000171 homodimer interface [polypeptide binding]; other site 688270000172 NADP binding site [chemical binding]; other site 688270000173 active site 688270000174 substrate binding site [chemical binding]; other site 688270000175 RmuC family; Region: RmuC; pfam02646 688270000176 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 688270000177 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 688270000178 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 688270000179 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 688270000180 putative active site [active] 688270000181 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 688270000182 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 688270000183 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 688270000184 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 688270000185 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 688270000186 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 688270000187 Protein of unknown function (DUF805); Region: DUF805; pfam05656 688270000188 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 688270000189 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 688270000190 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 688270000191 ATP-grasp domain; Region: ATP-grasp_4; cl17255 688270000192 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 688270000193 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 688270000194 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 688270000195 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 688270000196 ATP-grasp domain; Region: ATP-grasp_4; cl17255 688270000197 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 688270000198 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 688270000199 N-acetyl-D-glucosamine binding site [chemical binding]; other site 688270000200 catalytic residue [active] 688270000201 Predicted acetyltransferase [General function prediction only]; Region: COG2388 688270000202 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 688270000203 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 688270000204 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 688270000205 FeS/SAM binding site; other site 688270000206 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 688270000207 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 688270000208 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 688270000209 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 688270000210 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 688270000211 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 688270000212 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 688270000213 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 688270000214 Ligand binding site; other site 688270000215 Putative Catalytic site; other site 688270000216 DXD motif; other site 688270000217 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 688270000218 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 688270000219 active site 688270000220 substrate binding site [chemical binding]; other site 688270000221 metal binding site [ion binding]; metal-binding site 688270000222 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 688270000223 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 688270000224 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 688270000225 Walker A/P-loop; other site 688270000226 ATP binding site [chemical binding]; other site 688270000227 Q-loop/lid; other site 688270000228 ABC transporter signature motif; other site 688270000229 Walker B; other site 688270000230 D-loop; other site 688270000231 H-loop/switch region; other site 688270000232 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 688270000233 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 688270000234 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270000235 DNA binding residues [nucleotide binding] 688270000236 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 688270000237 16S rRNA methyltransferase B; Provisional; Region: PRK14902 688270000238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 688270000239 S-adenosylmethionine binding site [chemical binding]; other site 688270000240 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 688270000241 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 688270000242 dimerization interface [polypeptide binding]; other site 688270000243 ATP binding site [chemical binding]; other site 688270000244 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 688270000245 dimerization interface [polypeptide binding]; other site 688270000246 ATP binding site [chemical binding]; other site 688270000247 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 688270000248 putative active site [active] 688270000249 catalytic triad [active] 688270000250 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 688270000251 anti sigma factor interaction site; other site 688270000252 regulatory phosphorylation site [posttranslational modification]; other site 688270000253 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 688270000254 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 688270000255 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 688270000256 acyl-activating enzyme (AAE) consensus motif; other site 688270000257 putative AMP binding site [chemical binding]; other site 688270000258 putative active site [active] 688270000259 putative CoA binding site [chemical binding]; other site 688270000260 Transcriptional regulators [Transcription]; Region: MarR; COG1846 688270000261 MarR family; Region: MarR; pfam01047 688270000262 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 688270000263 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 688270000264 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 688270000265 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 688270000266 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 688270000267 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 688270000268 substrate binding site [chemical binding]; other site 688270000269 oxyanion hole (OAH) forming residues; other site 688270000270 trimer interface [polypeptide binding]; other site 688270000271 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 688270000272 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 688270000273 dimer interface [polypeptide binding]; other site 688270000274 active site 688270000275 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 688270000276 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 688270000277 active site 688270000278 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 688270000279 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 688270000280 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 688270000281 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 688270000282 active site 688270000283 homotetramer interface [polypeptide binding]; other site 688270000284 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 688270000285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 688270000286 Major Facilitator Superfamily; Region: MFS_1; pfam07690 688270000287 putative substrate translocation pore; other site 688270000288 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 688270000289 metal binding site [ion binding]; metal-binding site 688270000290 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 688270000291 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 688270000292 Zn binding site [ion binding]; other site 688270000293 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 688270000294 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 688270000295 MOSC domain; Region: MOSC; pfam03473 688270000296 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 688270000297 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 688270000298 Protein of unknown function DUF2625; Region: DUF2625; cl08177 688270000299 Helix-turn-helix domain; Region: HTH_18; pfam12833 688270000300 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 688270000301 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 688270000302 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 688270000303 active site triad [active] 688270000304 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 688270000305 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 688270000306 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 688270000307 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 688270000308 Trp docking motif [polypeptide binding]; other site 688270000309 FOG: WD40-like repeat [Function unknown]; Region: COG1520 688270000310 active site 688270000311 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 688270000312 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 688270000313 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 688270000314 active site 688270000315 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 688270000316 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 688270000317 TPR repeat; Region: TPR_11; pfam13414 688270000318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270000319 binding surface 688270000320 TPR motif; other site 688270000321 Tetratricopeptide repeat; Region: TPR_16; pfam13432 688270000322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270000323 binding surface 688270000324 TPR motif; other site 688270000325 TPR repeat; Region: TPR_11; pfam13414 688270000326 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 688270000327 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 688270000328 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 688270000329 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 688270000330 ligand binding site [chemical binding]; other site 688270000331 flexible hinge region; other site 688270000332 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 688270000333 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 688270000334 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 688270000335 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270000336 binding surface 688270000337 TPR repeat; Region: TPR_11; pfam13414 688270000338 TPR motif; other site 688270000339 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 688270000340 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 688270000341 active site 688270000342 Leucine rich repeat; Region: LRR_8; pfam13855 688270000343 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 688270000344 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 688270000345 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 688270000346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 688270000347 S-adenosylmethionine binding site [chemical binding]; other site 688270000348 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 688270000349 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 688270000350 YceI-like domain; Region: YceI; cl01001 688270000351 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 688270000352 E-class dimer interface [polypeptide binding]; other site 688270000353 P-class dimer interface [polypeptide binding]; other site 688270000354 active site 688270000355 Cu2+ binding site [ion binding]; other site 688270000356 Zn2+ binding site [ion binding]; other site 688270000357 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 688270000358 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 688270000359 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270000360 DNA binding residues [nucleotide binding] 688270000361 Anti-sigma-K factor rskA; Region: RskA; pfam10099 688270000362 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 688270000363 active site 688270000364 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 688270000365 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 688270000366 active site 688270000367 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 688270000368 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 688270000369 Probable Catalytic site; other site 688270000370 Protein of unknown function, DUF547; Region: DUF547; pfam04784 688270000371 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 688270000372 Surface antigen; Region: Bac_surface_Ag; pfam01103 688270000373 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270000374 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 688270000375 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 688270000376 N-terminal plug; other site 688270000377 ligand-binding site [chemical binding]; other site 688270000378 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 688270000379 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 688270000380 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 688270000381 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 688270000382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270000383 active site 688270000384 phosphorylation site [posttranslational modification] 688270000385 intermolecular recognition site; other site 688270000386 dimerization interface [polypeptide binding]; other site 688270000387 LytTr DNA-binding domain; Region: LytTR; smart00850 688270000388 2TM domain; Region: 2TM; pfam13239 688270000389 2TM domain; Region: 2TM; pfam13239 688270000390 Histidine kinase; Region: His_kinase; pfam06580 688270000391 2TM domain; Region: 2TM; pfam13239 688270000392 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 688270000393 Histidine kinase; Region: HisKA_2; pfam07568 688270000394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270000395 ATP binding site [chemical binding]; other site 688270000396 Mg2+ binding site [ion binding]; other site 688270000397 G-X-G motif; other site 688270000398 Response regulator receiver domain; Region: Response_reg; pfam00072 688270000399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270000400 active site 688270000401 phosphorylation site [posttranslational modification] 688270000402 intermolecular recognition site; other site 688270000403 dimerization interface [polypeptide binding]; other site 688270000404 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 688270000405 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 688270000406 putative Zn2+ binding site [ion binding]; other site 688270000407 putative DNA binding site [nucleotide binding]; other site 688270000408 AsnC family; Region: AsnC_trans_reg; pfam01037 688270000409 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 688270000410 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 688270000411 THF binding site; other site 688270000412 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 688270000413 substrate binding site [chemical binding]; other site 688270000414 THF binding site; other site 688270000415 zinc-binding site [ion binding]; other site 688270000416 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 688270000417 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 688270000418 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 688270000419 RNA binding surface [nucleotide binding]; other site 688270000420 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 688270000421 probable active site [active] 688270000422 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 688270000423 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 688270000424 ATP binding site [chemical binding]; other site 688270000425 Mg++ binding site [ion binding]; other site 688270000426 motif III; other site 688270000427 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 688270000428 nucleotide binding region [chemical binding]; other site 688270000429 ATP-binding site [chemical binding]; other site 688270000430 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 688270000431 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 688270000432 dimer interface [polypeptide binding]; other site 688270000433 ssDNA binding site [nucleotide binding]; other site 688270000434 tetramer (dimer of dimers) interface [polypeptide binding]; other site 688270000435 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 688270000436 Methyltransferase domain; Region: Methyltransf_26; pfam13659 688270000437 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 688270000438 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 688270000439 Low molecular weight phosphatase family; Region: LMWPc; cl00105 688270000440 active site 688270000441 EVE domain; Region: EVE; cl00728 688270000442 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 688270000443 active site 688270000444 Transposase IS200 like; Region: Y1_Tnp; pfam01797 688270000445 Nuclease-related domain; Region: NERD; pfam08378 688270000446 Family description; Region: UvrD_C_2; pfam13538 688270000447 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 688270000448 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 688270000449 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 688270000450 RNAase interaction site [polypeptide binding]; other site 688270000451 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 688270000452 non-specific DNA binding site [nucleotide binding]; other site 688270000453 salt bridge; other site 688270000454 sequence-specific DNA binding site [nucleotide binding]; other site 688270000455 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 688270000456 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 688270000457 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 688270000458 ATP binding site [chemical binding]; other site 688270000459 putative Mg++ binding site [ion binding]; other site 688270000460 HsdM N-terminal domain; Region: HsdM_N; pfam12161 688270000461 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 688270000462 Methyltransferase domain; Region: Methyltransf_26; pfam13659 688270000463 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 688270000464 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 688270000465 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 688270000466 AAA domain; Region: AAA_21; pfam13304 688270000467 AAA domain; Region: AAA_21; pfam13304 688270000468 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 688270000469 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 688270000470 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 688270000471 putative active site [active] 688270000472 putative NTP binding site [chemical binding]; other site 688270000473 putative nucleic acid binding site [nucleotide binding]; other site 688270000474 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 688270000475 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 688270000476 PemK-like protein; Region: PemK; pfam02452 688270000477 Transposase; Region: DEDD_Tnp_IS110; pfam01548 688270000478 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 688270000479 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 688270000480 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 688270000481 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 688270000482 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 688270000483 Uncharacterized conserved protein [Function unknown]; Region: COG1359 688270000484 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 688270000485 trimer interface [polypeptide binding]; other site 688270000486 putative Zn binding site [ion binding]; other site 688270000487 Predicted transcriptional regulators [Transcription]; Region: COG1733 688270000488 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 688270000489 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 688270000490 Trehalose utilisation; Region: ThuA; pfam06283 688270000491 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270000492 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 688270000493 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 688270000494 N-terminal plug; other site 688270000495 ligand-binding site [chemical binding]; other site 688270000496 Herpes UL74 glycoproteins; Region: Herpes_UL74; pfam07982 688270000497 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 688270000498 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 688270000499 Two component regulator propeller; Region: Reg_prop; pfam07494 688270000500 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 688270000501 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270000502 dimer interface [polypeptide binding]; other site 688270000503 phosphorylation site [posttranslational modification] 688270000504 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270000505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270000506 ATP binding site [chemical binding]; other site 688270000507 Mg2+ binding site [ion binding]; other site 688270000508 G-X-G motif; other site 688270000509 L-aspartate dehydrogenase; Reviewed; Region: PRK13304 688270000510 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 688270000511 Domain of unknown function DUF108; Region: DUF108; pfam01958 688270000512 hypothetical protein; Provisional; Region: PRK10039 688270000513 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 688270000514 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 688270000515 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 688270000516 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 688270000517 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 688270000518 short chain dehydrogenase; Provisional; Region: PRK06180 688270000519 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 688270000520 NADP binding site [chemical binding]; other site 688270000521 active site 688270000522 steroid binding site; other site 688270000523 Oxygen tolerance; Region: BatD; pfam13584 688270000524 Serine hydrolase; Region: Ser_hydrolase; pfam06821 688270000525 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 688270000526 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 688270000527 TrkA-C domain; Region: TrkA_C; pfam02080 688270000528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270000529 Response regulator receiver domain; Region: Response_reg; pfam00072 688270000530 active site 688270000531 phosphorylation site [posttranslational modification] 688270000532 intermolecular recognition site; other site 688270000533 dimerization interface [polypeptide binding]; other site 688270000534 Right handed beta helix region; Region: Beta_helix; pfam13229 688270000535 Spore germination protein; Region: Spore_permease; cl17796 688270000536 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 688270000537 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 688270000538 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 688270000539 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 688270000540 active site 688270000541 purine riboside binding site [chemical binding]; other site 688270000542 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 688270000543 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 688270000544 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 688270000545 PLD-like domain; Region: PLDc_2; pfam13091 688270000546 putative active site [active] 688270000547 catalytic site [active] 688270000548 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 688270000549 PLD-like domain; Region: PLDc_2; pfam13091 688270000550 putative active site [active] 688270000551 catalytic site [active] 688270000552 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 688270000553 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 688270000554 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 688270000555 Sulfate transporter family; Region: Sulfate_transp; pfam00916 688270000556 Sulfate transporter family; Region: Sulfate_transp; pfam00916 688270000557 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 688270000558 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 688270000559 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 688270000560 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 688270000561 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 688270000562 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 688270000563 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 688270000564 putative ligand binding site [chemical binding]; other site 688270000565 Trehalose utilisation; Region: ThuA; pfam06283 688270000566 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 688270000567 Alkaline phosphatase homologues; Region: alkPPc; smart00098 688270000568 active site 688270000569 dimer interface [polypeptide binding]; other site 688270000570 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 688270000571 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 688270000572 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 688270000573 inhibitor binding site; inhibition site 688270000574 active site 688270000575 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 688270000576 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_7; cd04502 688270000577 active site 688270000578 catalytic triad [active] 688270000579 oxyanion hole [active] 688270000580 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 688270000581 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 688270000582 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 688270000583 active site 688270000584 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 688270000585 Response regulator receiver domain; Region: Response_reg; pfam00072 688270000586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270000587 active site 688270000588 phosphorylation site [posttranslational modification] 688270000589 intermolecular recognition site; other site 688270000590 dimerization interface [polypeptide binding]; other site 688270000591 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270000592 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 688270000593 putative active site [active] 688270000594 heme pocket [chemical binding]; other site 688270000595 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270000596 dimer interface [polypeptide binding]; other site 688270000597 phosphorylation site [posttranslational modification] 688270000598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270000599 ATP binding site [chemical binding]; other site 688270000600 Mg2+ binding site [ion binding]; other site 688270000601 G-X-G motif; other site 688270000602 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 688270000603 active site 688270000604 catalytic residues [active] 688270000605 metal binding site [ion binding]; metal-binding site 688270000606 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 688270000607 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 688270000608 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 688270000609 trimer interface [polypeptide binding]; other site 688270000610 active site 688270000611 substrate binding site [chemical binding]; other site 688270000612 CoA binding site [chemical binding]; other site 688270000613 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 688270000614 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 688270000615 active site 688270000616 metal-binding site 688270000617 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 688270000618 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 688270000619 putative metal binding site; other site 688270000620 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 688270000621 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 688270000622 putative metal binding site; other site 688270000623 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 688270000624 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 688270000625 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 688270000626 active site 688270000627 NTP binding site [chemical binding]; other site 688270000628 metal binding triad [ion binding]; metal-binding site 688270000629 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 688270000630 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 688270000631 Zn2+ binding site [ion binding]; other site 688270000632 Mg2+ binding site [ion binding]; other site 688270000633 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 688270000634 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 688270000635 Tetratricopeptide repeat; Region: TPR_16; pfam13432 688270000636 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 688270000637 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 688270000638 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 688270000639 ligand binding site [chemical binding]; other site 688270000640 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 688270000641 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 688270000642 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 688270000643 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 688270000644 Domain of unknown function DUF11; Region: DUF11; pfam01345 688270000645 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 688270000646 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 688270000647 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 688270000648 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 688270000649 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 688270000650 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 688270000651 Walker A/P-loop; other site 688270000652 ATP binding site [chemical binding]; other site 688270000653 Q-loop/lid; other site 688270000654 ABC transporter signature motif; other site 688270000655 Walker B; other site 688270000656 D-loop; other site 688270000657 H-loop/switch region; other site 688270000658 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 688270000659 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 688270000660 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 688270000661 excinuclease ABC subunit B; Provisional; Region: PRK05298 688270000662 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 688270000663 ATP binding site [chemical binding]; other site 688270000664 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 688270000665 nucleotide binding region [chemical binding]; other site 688270000666 ATP-binding site [chemical binding]; other site 688270000667 Ultra-violet resistance protein B; Region: UvrB; pfam12344 688270000668 UvrB/uvrC motif; Region: UVR; pfam02151 688270000669 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 688270000670 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 688270000671 putative dimer interface [polypeptide binding]; other site 688270000672 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 688270000673 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 688270000674 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 688270000675 CoA-ligase; Region: Ligase_CoA; pfam00549 688270000676 diaminopimelate decarboxylase; Region: lysA; TIGR01048 688270000677 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 688270000678 active site 688270000679 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 688270000680 substrate binding site [chemical binding]; other site 688270000681 catalytic residues [active] 688270000682 dimer interface [polypeptide binding]; other site 688270000683 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 688270000684 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 688270000685 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 688270000686 active site residue [active] 688270000687 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 688270000688 active site residue [active] 688270000689 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 688270000690 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 688270000691 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 688270000692 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 688270000693 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 688270000694 active site 688270000695 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270000696 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 688270000697 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 688270000698 N-terminal plug; other site 688270000699 ligand-binding site [chemical binding]; other site 688270000700 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 688270000701 Imelysin; Region: Peptidase_M75; pfam09375 688270000702 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 688270000703 active site 688270000704 catalytic residues [active] 688270000705 metal binding site [ion binding]; metal-binding site 688270000706 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 688270000707 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 688270000708 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 688270000709 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 688270000710 quinone interaction residues [chemical binding]; other site 688270000711 active site 688270000712 catalytic residues [active] 688270000713 FMN binding site [chemical binding]; other site 688270000714 substrate binding site [chemical binding]; other site 688270000715 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270000716 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270000717 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 688270000718 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270000719 peptidase T; Region: peptidase-T; TIGR01882 688270000720 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 688270000721 metal binding site [ion binding]; metal-binding site 688270000722 dimer interface [polypeptide binding]; other site 688270000723 Preprotein translocase subunit; Region: YajC; pfam02699 688270000724 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 688270000725 transcription antitermination factor NusB; Region: nusB; TIGR01951 688270000726 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 688270000727 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 688270000728 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 688270000729 Walker A/P-loop; other site 688270000730 ATP binding site [chemical binding]; other site 688270000731 Q-loop/lid; other site 688270000732 ABC transporter signature motif; other site 688270000733 Walker B; other site 688270000734 D-loop; other site 688270000735 H-loop/switch region; other site 688270000736 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 688270000737 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 688270000738 putative active site [active] 688270000739 Zn binding site [ion binding]; other site 688270000740 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 688270000741 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 688270000742 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Region: LPLAT_AAK14816-like; cd07992 688270000743 putative acyl-acceptor binding pocket; other site 688270000744 bile acid transporter; Region: bass; TIGR00841 688270000745 Sodium Bile acid symporter family; Region: SBF; cl17470 688270000746 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 688270000747 dimer interface [polypeptide binding]; other site 688270000748 putative tRNA-binding site [nucleotide binding]; other site 688270000749 metal-dependent hydrolase; Provisional; Region: PRK13291 688270000750 DinB superfamily; Region: DinB_2; pfam12867 688270000751 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 688270000752 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 688270000753 dimer interface [polypeptide binding]; other site 688270000754 decamer (pentamer of dimers) interface [polypeptide binding]; other site 688270000755 catalytic triad [active] 688270000756 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 688270000757 DNA-binding site [nucleotide binding]; DNA binding site 688270000758 RNA-binding motif; other site 688270000759 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 688270000760 active site 688270000761 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 688270000762 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 688270000763 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 688270000764 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 688270000765 active site 688270000766 Zn binding site [ion binding]; other site 688270000767 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 688270000768 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 688270000769 PA/protease or protease-like domain interface [polypeptide binding]; other site 688270000770 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 688270000771 Peptidase family M28; Region: Peptidase_M28; pfam04389 688270000772 metal binding site [ion binding]; metal-binding site 688270000773 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 688270000774 Response regulator receiver domain; Region: Response_reg; pfam00072 688270000775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270000776 active site 688270000777 phosphorylation site [posttranslational modification] 688270000778 intermolecular recognition site; other site 688270000779 dimerization interface [polypeptide binding]; other site 688270000780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 688270000781 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 688270000782 Walker A motif; other site 688270000783 ATP binding site [chemical binding]; other site 688270000784 Walker B motif; other site 688270000785 arginine finger; other site 688270000786 Mechanosensitive ion channel; Region: MS_channel; pfam00924 688270000787 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 688270000788 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 688270000789 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 688270000790 Walker A/P-loop; other site 688270000791 ATP binding site [chemical binding]; other site 688270000792 Q-loop/lid; other site 688270000793 ABC transporter signature motif; other site 688270000794 Walker B; other site 688270000795 D-loop; other site 688270000796 H-loop/switch region; other site 688270000797 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 688270000798 chaperone protein DnaJ; Provisional; Region: PRK14289 688270000799 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 688270000800 HSP70 interaction site [polypeptide binding]; other site 688270000801 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 688270000802 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 688270000803 dimer interface [polypeptide binding]; other site 688270000804 heat shock protein GrpE; Provisional; Region: PRK14140 688270000805 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 688270000806 dimer interface [polypeptide binding]; other site 688270000807 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 688270000808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270000809 TIGR01777 family protein; Region: yfcH 688270000810 NAD(P) binding site [chemical binding]; other site 688270000811 active site 688270000812 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 688270000813 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 688270000814 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 688270000815 homodimer interface [polypeptide binding]; other site 688270000816 substrate-cofactor binding pocket; other site 688270000817 catalytic residue [active] 688270000818 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 688270000819 metal binding site [ion binding]; metal-binding site 688270000820 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 688270000821 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 688270000822 Nitrogen regulatory protein P-II; Region: P-II; smart00938 688270000823 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 688270000824 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 688270000825 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 688270000826 Nitrogen regulatory protein P-II; Region: P-II; smart00938 688270000827 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 688270000828 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 688270000829 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 688270000830 DJ-1 family protein; Region: not_thiJ; TIGR01383 688270000831 conserved cys residue [active] 688270000832 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 688270000833 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 688270000834 dimerization interface [polypeptide binding]; other site 688270000835 putative Zn2+ binding site [ion binding]; other site 688270000836 putative DNA binding site [nucleotide binding]; other site 688270000837 AsnC family; Region: AsnC_trans_reg; pfam01037 688270000838 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 688270000839 B12 binding site [chemical binding]; other site 688270000840 cobalt ligand [ion binding]; other site 688270000841 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 688270000842 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 688270000843 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 688270000844 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 688270000845 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 688270000846 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 688270000847 putative active site [active] 688270000848 putative substrate binding site [chemical binding]; other site 688270000849 putative cosubstrate binding site; other site 688270000850 catalytic site [active] 688270000851 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 688270000852 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 688270000853 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 688270000854 active site 688270000855 dimer interface [polypeptide binding]; other site 688270000856 peptide chain release factor 1; Validated; Region: prfA; PRK00591 688270000857 This domain is found in peptide chain release factors; Region: PCRF; smart00937 688270000858 RF-1 domain; Region: RF-1; pfam00472 688270000859 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 688270000860 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 688270000861 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 688270000862 ApbE family; Region: ApbE; pfam02424 688270000863 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 688270000864 iron-sulfur cluster [ion binding]; other site 688270000865 [2Fe-2S] cluster binding site [ion binding]; other site 688270000866 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 688270000867 dimerization interface [polypeptide binding]; other site 688270000868 ATP binding site [chemical binding]; other site 688270000869 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 688270000870 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 688270000871 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 688270000872 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 688270000873 glutamine synthetase; Region: PLN02284 688270000874 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 688270000875 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 688270000876 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 688270000877 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 688270000878 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 688270000879 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 688270000880 non-specific DNA binding site [nucleotide binding]; other site 688270000881 salt bridge; other site 688270000882 sequence-specific DNA binding site [nucleotide binding]; other site 688270000883 HipA-like N-terminal domain; Region: HipA_N; pfam07805 688270000884 HipA-like C-terminal domain; Region: HipA_C; pfam07804 688270000885 Predicted metalloprotease [General function prediction only]; Region: COG2321 688270000886 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 688270000887 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 688270000888 Cupin domain; Region: Cupin_2; cl17218 688270000889 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 688270000890 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 688270000891 fructuronate transporter; Provisional; Region: PRK10034; cl15264 688270000892 fructuronate transporter; Provisional; Region: PRK10034; cl15264 688270000893 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 688270000894 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 688270000895 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 688270000896 active site pocket [active] 688270000897 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 688270000898 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 688270000899 tetramerization interface [polypeptide binding]; other site 688270000900 NAD(P) binding site [chemical binding]; other site 688270000901 catalytic residues [active] 688270000902 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 688270000903 Entner-Doudoroff aldolase; Region: eda; TIGR01182 688270000904 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 688270000905 active site 688270000906 intersubunit interface [polypeptide binding]; other site 688270000907 catalytic residue [active] 688270000908 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 688270000909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 688270000910 D-galactonate transporter; Region: 2A0114; TIGR00893 688270000911 putative substrate translocation pore; other site 688270000912 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 688270000913 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 688270000914 active site pocket [active] 688270000915 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 688270000916 Sulfatase; Region: Sulfatase; pfam00884 688270000917 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 688270000918 Sulfatase; Region: Sulfatase; pfam00884 688270000919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 688270000920 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 688270000921 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 688270000922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 688270000923 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 688270000924 active site 688270000925 catalytic residues [active] 688270000926 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 688270000927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 688270000928 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 688270000929 Sulfatase; Region: Sulfatase; cl17466 688270000930 Sulfatase; Region: Sulfatase; cl17466 688270000931 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 688270000932 Sulfatase; Region: Sulfatase; cl17466 688270000933 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 688270000934 Sulfatase; Region: Sulfatase; pfam00884 688270000935 Family description; Region: VCBS; pfam13517 688270000936 Family description; Region: VCBS; pfam13517 688270000937 Family description; Region: VCBS; pfam13517 688270000938 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 688270000939 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 688270000940 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270000941 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270000942 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 688270000943 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270000944 starch binding outer membrane protein SusD; Region: SusD; cl17845 688270000945 SusD family; Region: SusD; pfam07980 688270000946 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 688270000947 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 688270000948 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 688270000949 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 688270000950 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 688270000951 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 688270000952 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 688270000953 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 688270000954 active site 688270000955 DNA binding site [nucleotide binding] 688270000956 Int/Topo IB signature motif; other site 688270000957 Integrase core domain; Region: rve; pfam00665 688270000958 Integrase core domain; Region: rve_3; pfam13683 688270000959 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 688270000960 30S subunit binding site; other site 688270000961 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 688270000962 dimer interface [polypeptide binding]; other site 688270000963 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 688270000964 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 688270000965 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 688270000966 CsbD-like; Region: CsbD; pfam05532 688270000967 L-fucose transporter; Provisional; Region: PRK10133; cl17665 688270000968 putative transporter; Provisional; Region: PRK10484 688270000969 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 688270000970 Na binding site [ion binding]; other site 688270000971 Family of unknown function (DUF706); Region: DUF706; pfam05153 688270000972 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 688270000973 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 688270000974 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270000975 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270000976 dimer interface [polypeptide binding]; other site 688270000977 phosphorylation site [posttranslational modification] 688270000978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270000979 ATP binding site [chemical binding]; other site 688270000980 Mg2+ binding site [ion binding]; other site 688270000981 G-X-G motif; other site 688270000982 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 688270000983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270000984 active site 688270000985 phosphorylation site [posttranslational modification] 688270000986 intermolecular recognition site; other site 688270000987 dimerization interface [polypeptide binding]; other site 688270000988 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 688270000989 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 688270000990 Family description; Region: VCBS; pfam13517 688270000991 Family description; Region: VCBS; pfam13517 688270000992 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 688270000993 Family description; Region: VCBS; pfam13517 688270000994 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 688270000995 starch binding outer membrane protein SusD; Region: SusD; cd08977 688270000996 SusD family; Region: SusD; pfam07980 688270000997 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270000998 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270000999 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 688270001000 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 688270001001 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270001002 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 688270001003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 688270001004 putative substrate translocation pore; other site 688270001005 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 688270001006 nudix motif; other site 688270001007 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 688270001008 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 688270001009 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 688270001010 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 688270001011 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 688270001012 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 688270001013 dimer interface [polypeptide binding]; other site 688270001014 active site 688270001015 Transcriptional regulators [Transcription]; Region: PurR; COG1609 688270001016 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 688270001017 DNA binding site [nucleotide binding] 688270001018 domain linker motif; other site 688270001019 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 688270001020 ligand binding site [chemical binding]; other site 688270001021 dimerization interface [polypeptide binding]; other site 688270001022 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 688270001023 Sulphur transport; Region: Sulf_transp; pfam04143 688270001024 Predicted transporter component [General function prediction only]; Region: COG2391 688270001025 Sulphur transport; Region: Sulf_transp; pfam04143 688270001026 putative oxidoreductase; Provisional; Region: PRK11579 688270001027 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 688270001028 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 688270001029 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 688270001030 active site 688270001031 catalytic residues [active] 688270001032 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 688270001033 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 688270001034 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 688270001035 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 688270001036 active site 688270001037 catalytic residues [active] 688270001038 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 688270001039 starch binding outer membrane protein SusD; Region: SusD; cd08977 688270001040 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270001041 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270001042 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 688270001043 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 688270001044 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 688270001045 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 688270001046 dimerization interface [polypeptide binding]; other site 688270001047 DNA binding residues [nucleotide binding] 688270001048 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 688270001049 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 688270001050 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 688270001051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 688270001052 S-adenosylmethionine binding site [chemical binding]; other site 688270001053 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 688270001054 triosephosphate isomerase; Provisional; Region: PRK14567 688270001055 substrate binding site [chemical binding]; other site 688270001056 dimer interface [polypeptide binding]; other site 688270001057 catalytic triad [active] 688270001058 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 688270001059 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 688270001060 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 688270001061 dihydropteroate synthase; Region: DHPS; TIGR01496 688270001062 substrate binding pocket [chemical binding]; other site 688270001063 dimer interface [polypeptide binding]; other site 688270001064 inhibitor binding site; inhibition site 688270001065 Uncharacterized conserved protein [Function unknown]; Region: COG1624 688270001066 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 688270001067 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 688270001068 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 688270001069 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 688270001070 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 688270001071 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 688270001072 Walker A/P-loop; other site 688270001073 ATP binding site [chemical binding]; other site 688270001074 Q-loop/lid; other site 688270001075 ABC transporter signature motif; other site 688270001076 Walker B; other site 688270001077 D-loop; other site 688270001078 H-loop/switch region; other site 688270001079 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 688270001080 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 688270001081 dimerization interface 3.5A [polypeptide binding]; other site 688270001082 active site 688270001083 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 688270001084 active site 688270001085 metal binding site [ion binding]; metal-binding site 688270001086 homotetramer interface [polypeptide binding]; other site 688270001087 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 688270001088 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 688270001089 transcription termination factor Rho; Provisional; Region: rho; PRK09376 688270001090 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 688270001091 RNA binding site [nucleotide binding]; other site 688270001092 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 688270001093 multimer interface [polypeptide binding]; other site 688270001094 Walker A motif; other site 688270001095 ATP binding site [chemical binding]; other site 688270001096 Walker B motif; other site 688270001097 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 688270001098 prolyl-tRNA synthetase; Provisional; Region: PRK08661 688270001099 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 688270001100 dimer interface [polypeptide binding]; other site 688270001101 motif 1; other site 688270001102 active site 688270001103 motif 2; other site 688270001104 motif 3; other site 688270001105 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 688270001106 anticodon binding site; other site 688270001107 zinc-binding site [ion binding]; other site 688270001108 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 688270001109 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 688270001110 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 688270001111 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 688270001112 GTP cyclohydrolase I; Provisional; Region: PLN03044 688270001113 active site 688270001114 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 688270001115 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 688270001116 active site 688270001117 HIGH motif; other site 688270001118 nucleotide binding site [chemical binding]; other site 688270001119 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 688270001120 KMSKS motif; other site 688270001121 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 688270001122 anticodon binding site; other site 688270001123 tRNA binding surface [nucleotide binding]; other site 688270001124 Haemolytic domain; Region: Haemolytic; pfam01809 688270001125 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 688270001126 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 688270001127 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 688270001128 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 688270001129 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 688270001130 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 688270001131 ABC transporter signature motif; other site 688270001132 Walker B; other site 688270001133 D-loop; other site 688270001134 H-loop/switch region; other site 688270001135 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 688270001136 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 688270001137 Walker A/P-loop; other site 688270001138 ATP binding site [chemical binding]; other site 688270001139 Q-loop/lid; other site 688270001140 ABC transporter signature motif; other site 688270001141 Walker B; other site 688270001142 D-loop; other site 688270001143 H-loop/switch region; other site 688270001144 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 688270001145 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 688270001146 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 688270001147 Protein export membrane protein; Region: SecD_SecF; pfam02355 688270001148 malate dehydrogenase; Reviewed; Region: PRK06223 688270001149 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 688270001150 dimer interface [polypeptide binding]; other site 688270001151 NAD(P) binding site [chemical binding]; other site 688270001152 tetramer (dimer of dimers) interface [polypeptide binding]; other site 688270001153 substrate binding site [chemical binding]; other site 688270001154 Integrase core domain; Region: rve; pfam00665 688270001155 Integrase core domain; Region: rve_3; pfam13683 688270001156 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 688270001157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270001158 ATP binding site [chemical binding]; other site 688270001159 Mg2+ binding site [ion binding]; other site 688270001160 G-X-G motif; other site 688270001161 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 688270001162 anchoring element; other site 688270001163 dimer interface [polypeptide binding]; other site 688270001164 ATP binding site [chemical binding]; other site 688270001165 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 688270001166 active site 688270001167 putative metal-binding site [ion binding]; other site 688270001168 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 688270001169 asparagine synthetase B; Provisional; Region: asnB; PRK09431 688270001170 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 688270001171 active site 688270001172 dimer interface [polypeptide binding]; other site 688270001173 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 688270001174 Ligand Binding Site [chemical binding]; other site 688270001175 Molecular Tunnel; other site 688270001176 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 688270001177 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 688270001178 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 688270001179 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 688270001180 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 688270001181 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 688270001182 active site 688270001183 malate:quinone oxidoreductase; Validated; Region: PRK05257 688270001184 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 688270001185 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 688270001186 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 688270001187 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 688270001188 ABC transporter; Region: ABC_tran_2; pfam12848 688270001189 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 688270001190 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 688270001191 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 688270001192 ligand binding site [chemical binding]; other site 688270001193 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270001194 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 688270001195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270001196 TPR motif; other site 688270001197 binding surface 688270001198 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 688270001199 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 688270001200 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 688270001201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 688270001202 binding surface 688270001203 TPR motif; other site 688270001204 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 688270001205 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270001206 putative active site [active] 688270001207 heme pocket [chemical binding]; other site 688270001208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270001209 dimer interface [polypeptide binding]; other site 688270001210 phosphorylation site [posttranslational modification] 688270001211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270001212 ATP binding site [chemical binding]; other site 688270001213 Mg2+ binding site [ion binding]; other site 688270001214 G-X-G motif; other site 688270001215 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 688270001216 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 688270001217 Walker A/P-loop; other site 688270001218 ATP binding site [chemical binding]; other site 688270001219 Q-loop/lid; other site 688270001220 ABC transporter signature motif; other site 688270001221 Walker B; other site 688270001222 D-loop; other site 688270001223 H-loop/switch region; other site 688270001224 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 688270001225 nudix motif; other site 688270001226 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 688270001227 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 688270001228 nucleotide binding site [chemical binding]; other site 688270001229 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 688270001230 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 688270001231 G1 box; other site 688270001232 putative GEF interaction site [polypeptide binding]; other site 688270001233 GTP/Mg2+ binding site [chemical binding]; other site 688270001234 Switch I region; other site 688270001235 G2 box; other site 688270001236 G3 box; other site 688270001237 Switch II region; other site 688270001238 G4 box; other site 688270001239 G5 box; other site 688270001240 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 688270001241 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 688270001242 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 688270001243 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 688270001244 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 688270001245 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 688270001246 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 688270001247 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 688270001248 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 688270001249 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 688270001250 Saccharopine Dehydrogenase like proteins; Region: SDH_like; cd05199 688270001251 active site 688270001252 ligand binding site [chemical binding]; other site 688270001253 NAD(P) binding site [chemical binding]; other site 688270001254 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 688270001255 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 688270001256 Integrase core domain; Region: rve; pfam00665 688270001257 Integrase core domain; Region: rve_3; pfam13683 688270001258 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 688270001259 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 688270001260 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 688270001261 HlyD family secretion protein; Region: HlyD_3; pfam13437 688270001262 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 688270001263 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 688270001264 active site 688270001265 dimer interface [polypeptide binding]; other site 688270001266 Response regulator receiver domain; Region: Response_reg; pfam00072 688270001267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270001268 active site 688270001269 phosphorylation site [posttranslational modification] 688270001270 intermolecular recognition site; other site 688270001271 dimerization interface [polypeptide binding]; other site 688270001272 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 688270001273 ATP-grasp domain; Region: ATP-grasp_4; cl17255 688270001274 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 688270001275 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 688270001276 active site 688270001277 catalytic site [active] 688270001278 substrate binding site [chemical binding]; other site 688270001279 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 688270001280 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 688270001281 GIY-YIG motif/motif A; other site 688270001282 active site 688270001283 catalytic site [active] 688270001284 putative DNA binding site [nucleotide binding]; other site 688270001285 metal binding site [ion binding]; metal-binding site 688270001286 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 688270001287 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 688270001288 active site residue [active] 688270001289 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 688270001290 active site residue [active] 688270001291 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 688270001292 high affinity sulphate transporter 1; Region: sulP; TIGR00815 688270001293 Sulfate transporter family; Region: Sulfate_transp; pfam00916 688270001294 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 688270001295 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 688270001296 active site 688270001297 catalytic residues [active] 688270001298 glutamate carboxypeptidase; Reviewed; Region: PRK06133 688270001299 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 688270001300 metal binding site [ion binding]; metal-binding site 688270001301 dimer interface [polypeptide binding]; other site 688270001302 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 688270001303 FtsX-like permease family; Region: FtsX; pfam02687 688270001304 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 688270001305 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 688270001306 Coenzyme A binding pocket [chemical binding]; other site 688270001307 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 688270001308 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 688270001309 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 688270001310 Flagellin N-methylase; Region: FliB; pfam03692 688270001311 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 688270001312 Methyltransferase domain; Region: Methyltransf_23; pfam13489 688270001313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 688270001314 S-adenosylmethionine binding site [chemical binding]; other site 688270001315 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 688270001316 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 688270001317 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 688270001318 Zonular occludens toxin (Zot); Region: Zot; cl17485 688270001319 Cupin domain; Region: Cupin_2; pfam07883 688270001320 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 688270001321 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 688270001322 PGAP1-like protein; Region: PGAP1; pfam07819 688270001323 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 688270001324 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 688270001325 putative metal binding site [ion binding]; other site 688270001326 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270001327 PAS domain; Region: PAS_9; pfam13426 688270001328 putative active site [active] 688270001329 heme pocket [chemical binding]; other site 688270001330 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270001331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270001332 ATP binding site [chemical binding]; other site 688270001333 Mg2+ binding site [ion binding]; other site 688270001334 G-X-G motif; other site 688270001335 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185 688270001336 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 688270001337 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 688270001338 homodimer interface [polypeptide binding]; other site 688270001339 NADP binding site [chemical binding]; other site 688270001340 substrate binding site [chemical binding]; other site 688270001341 signal recognition particle protein; Provisional; Region: PRK10867 688270001342 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 688270001343 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 688270001344 P loop; other site 688270001345 GTP binding site [chemical binding]; other site 688270001346 Signal peptide binding domain; Region: SRP_SPB; pfam02978 688270001347 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 688270001348 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 688270001349 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270001350 DNA binding residues [nucleotide binding] 688270001351 FecR protein; Region: FecR; pfam04773 688270001352 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270001353 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 688270001354 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270001355 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 688270001356 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 688270001357 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 688270001358 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 688270001359 active site 688270001360 HIGH motif; other site 688270001361 nucleotide binding site [chemical binding]; other site 688270001362 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 688270001363 KMSK motif region; other site 688270001364 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 688270001365 tRNA binding surface [nucleotide binding]; other site 688270001366 anticodon binding site; other site 688270001367 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 688270001368 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270001369 NAD(P) binding site [chemical binding]; other site 688270001370 active site 688270001371 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 688270001372 BCCT family transporter; Region: BCCT; pfam02028 688270001373 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 688270001374 Amidinotransferase; Region: Amidinotransf; pfam02274 688270001375 Amidinotransferase; Region: Amidinotransf; cl12043 688270001376 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 688270001377 dimer interface [polypeptide binding]; other site 688270001378 Citrate synthase; Region: Citrate_synt; pfam00285 688270001379 active site 688270001380 citrylCoA binding site [chemical binding]; other site 688270001381 NADH binding [chemical binding]; other site 688270001382 cationic pore residues; other site 688270001383 oxalacetate/citrate binding site [chemical binding]; other site 688270001384 coenzyme A binding site [chemical binding]; other site 688270001385 catalytic triad [active] 688270001386 glycogen/starch synthase, ADP-glucose type; Region: glgA; TIGR02095 688270001387 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 688270001388 ADP-binding pocket [chemical binding]; other site 688270001389 homodimer interface [polypeptide binding]; other site 688270001390 enolase; Provisional; Region: eno; PRK00077 688270001391 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 688270001392 dimer interface [polypeptide binding]; other site 688270001393 metal binding site [ion binding]; metal-binding site 688270001394 substrate binding pocket [chemical binding]; other site 688270001395 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 688270001396 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 688270001397 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 688270001398 catalytic site [active] 688270001399 subunit interface [polypeptide binding]; other site 688270001400 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 688270001401 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 688270001402 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 688270001403 alphaNTD homodimer interface [polypeptide binding]; other site 688270001404 alphaNTD - beta interaction site [polypeptide binding]; other site 688270001405 alphaNTD - beta' interaction site [polypeptide binding]; other site 688270001406 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 688270001407 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 688270001408 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 688270001409 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 688270001410 RNA binding surface [nucleotide binding]; other site 688270001411 30S ribosomal protein S11; Validated; Region: PRK05309 688270001412 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 688270001413 30S ribosomal protein S13; Region: bact_S13; TIGR03631 688270001414 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 688270001415 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 688270001416 rRNA binding site [nucleotide binding]; other site 688270001417 predicted 30S ribosome binding site; other site 688270001418 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 688270001419 SecY translocase; Region: SecY; pfam00344 688270001420 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 688270001421 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 688270001422 23S rRNA binding site [nucleotide binding]; other site 688270001423 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 688270001424 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 688270001425 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 688270001426 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 688270001427 5S rRNA interface [nucleotide binding]; other site 688270001428 L27 interface [polypeptide binding]; other site 688270001429 23S rRNA interface [nucleotide binding]; other site 688270001430 L5 interface [polypeptide binding]; other site 688270001431 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 688270001432 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 688270001433 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 688270001434 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 688270001435 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 688270001436 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 688270001437 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 688270001438 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 688270001439 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 688270001440 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 688270001441 RNA binding site [nucleotide binding]; other site 688270001442 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 688270001443 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 688270001444 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 688270001445 putative translocon interaction site; other site 688270001446 signal recognition particle (SRP54) interaction site; other site 688270001447 L23 interface [polypeptide binding]; other site 688270001448 trigger factor interaction site; other site 688270001449 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 688270001450 23S rRNA interface [nucleotide binding]; other site 688270001451 5S rRNA interface [nucleotide binding]; other site 688270001452 putative antibiotic binding site [chemical binding]; other site 688270001453 L25 interface [polypeptide binding]; other site 688270001454 L27 interface [polypeptide binding]; other site 688270001455 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 688270001456 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 688270001457 G-X-X-G motif; other site 688270001458 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 688270001459 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 688270001460 putative translocon binding site; other site 688270001461 protein-rRNA interface [nucleotide binding]; other site 688270001462 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 688270001463 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 688270001464 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 688270001465 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 688270001466 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 688270001467 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 688270001468 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 688270001469 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 688270001470 elongation factor G; Reviewed; Region: PRK12739 688270001471 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 688270001472 G1 box; other site 688270001473 putative GEF interaction site [polypeptide binding]; other site 688270001474 GTP/Mg2+ binding site [chemical binding]; other site 688270001475 Switch I region; other site 688270001476 G2 box; other site 688270001477 G3 box; other site 688270001478 Switch II region; other site 688270001479 G4 box; other site 688270001480 G5 box; other site 688270001481 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 688270001482 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 688270001483 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 688270001484 30S ribosomal protein S7; Validated; Region: PRK05302 688270001485 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 688270001486 S17 interaction site [polypeptide binding]; other site 688270001487 S8 interaction site; other site 688270001488 16S rRNA interaction site [nucleotide binding]; other site 688270001489 streptomycin interaction site [chemical binding]; other site 688270001490 23S rRNA interaction site [nucleotide binding]; other site 688270001491 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 688270001492 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270001493 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 688270001494 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270001495 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270001496 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 688270001497 starch binding outer membrane protein SusD; Region: SusD; cd08977 688270001498 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 688270001499 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 688270001500 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 688270001501 Rhomboid family; Region: Rhomboid; pfam01694 688270001502 recombination factor protein RarA; Reviewed; Region: PRK13342 688270001503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 688270001504 Walker A motif; other site 688270001505 ATP binding site [chemical binding]; other site 688270001506 Walker B motif; other site 688270001507 arginine finger; other site 688270001508 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 688270001509 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 688270001510 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 688270001511 motif II; other site 688270001512 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 688270001513 putative active site [active] 688270001514 hypothetical protein; Reviewed; Region: PRK00024 688270001515 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 688270001516 MPN+ (JAMM) motif; other site 688270001517 Zinc-binding site [ion binding]; other site 688270001518 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 688270001519 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 688270001520 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 688270001521 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 688270001522 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 688270001523 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 688270001524 short chain dehydrogenase; Provisional; Region: PRK08339 688270001525 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 688270001526 putative NAD(P) binding site [chemical binding]; other site 688270001527 putative active site [active] 688270001528 MG2 domain; Region: A2M_N; pfam01835 688270001529 Alpha-2-macroglobulin family; Region: A2M; pfam00207 688270001530 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 688270001531 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270001532 Transglutaminase/protease-like homologues; Region: TGc; smart00460 688270001533 DinB superfamily; Region: DinB_2; pfam12867 688270001534 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 688270001535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270001536 active site 688270001537 phosphorylation site [posttranslational modification] 688270001538 intermolecular recognition site; other site 688270001539 dimerization interface [polypeptide binding]; other site 688270001540 LytTr DNA-binding domain; Region: LytTR; smart00850 688270001541 Histidine kinase; Region: His_kinase; pfam06580 688270001542 Histidine kinase; Region: His_kinase; pfam06580 688270001543 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 688270001544 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 688270001545 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 688270001546 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 688270001547 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 688270001548 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 688270001549 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 688270001550 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 688270001551 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 688270001552 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 688270001553 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 688270001554 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 688270001555 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 688270001556 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 688270001557 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 688270001558 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 688270001559 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 688270001560 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 688270001561 GTPase CgtA; Reviewed; Region: obgE; PRK12299 688270001562 GTP1/OBG; Region: GTP1_OBG; pfam01018 688270001563 Obg GTPase; Region: Obg; cd01898 688270001564 G1 box; other site 688270001565 GTP/Mg2+ binding site [chemical binding]; other site 688270001566 Switch I region; other site 688270001567 G2 box; other site 688270001568 G3 box; other site 688270001569 Switch II region; other site 688270001570 G4 box; other site 688270001571 G5 box; other site 688270001572 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 688270001573 active site 688270001574 adenylate kinase; Reviewed; Region: adk; PRK00279 688270001575 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 688270001576 AMP-binding site [chemical binding]; other site 688270001577 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 688270001578 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 688270001579 ATP-grasp domain; Region: ATP-grasp; pfam02222 688270001580 AIR carboxylase; Region: AIRC; pfam00731 688270001581 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 688270001582 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 688270001583 active site 688270001584 Zn binding site [ion binding]; other site 688270001585 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 688270001586 Cytochrome c oxidase subunit IV. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_IV; cl02792 688270001587 Protein of unknown function (DUF805); Region: DUF805; pfam05656 688270001588 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 688270001589 Protein of unknown function (DUF805); Region: DUF805; pfam05656 688270001590 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 688270001591 Bacterial SH3 domain; Region: SH3_3; cl17532 688270001592 Domain of unknown function (DUF4209); Region: DUF4209; pfam13910 688270001593 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 688270001594 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 688270001595 PLD-like domain; Region: PLDc_2; pfam13091 688270001596 putative homodimer interface [polypeptide binding]; other site 688270001597 putative active site [active] 688270001598 catalytic site [active] 688270001599 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 688270001600 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 688270001601 active site 688270001602 TPR repeat; Region: TPR_11; pfam13414 688270001603 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270001604 TPR motif; other site 688270001605 binding surface 688270001606 Fic family protein [Function unknown]; Region: COG3177 688270001607 Fic/DOC family; Region: Fic; pfam02661 688270001608 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 688270001609 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 688270001610 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 688270001611 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 688270001612 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 688270001613 OsmC-like protein; Region: OsmC; pfam02566 688270001614 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 688270001615 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 688270001616 Predicted transcriptional regulators [Transcription]; Region: COG1510 688270001617 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 688270001618 putative DNA binding site [nucleotide binding]; other site 688270001619 putative Zn2+ binding site [ion binding]; other site 688270001620 Methyltransferase domain; Region: Methyltransf_31; pfam13847 688270001621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 688270001622 S-adenosylmethionine binding site [chemical binding]; other site 688270001623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270001624 TIGR01777 family protein; Region: yfcH 688270001625 NAD(P) binding site [chemical binding]; other site 688270001626 active site 688270001627 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 688270001628 active site residue [active] 688270001629 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 688270001630 RNA polymerase sigma factor; Provisional; Region: PRK12520 688270001631 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270001632 DNA binding residues [nucleotide binding] 688270001633 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 688270001634 glycine dehydrogenase; Provisional; Region: PRK05367 688270001635 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 688270001636 tetramer interface [polypeptide binding]; other site 688270001637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270001638 catalytic residue [active] 688270001639 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 688270001640 tetramer interface [polypeptide binding]; other site 688270001641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270001642 catalytic residue [active] 688270001643 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 688270001644 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 688270001645 dimer interface [polypeptide binding]; other site 688270001646 active site 688270001647 CoA binding pocket [chemical binding]; other site 688270001648 Methyltransferase domain; Region: Methyltransf_23; pfam13489 688270001649 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 688270001650 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 688270001651 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 688270001652 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270001653 DNA binding residues [nucleotide binding] 688270001654 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 688270001655 Predicted transcriptional regulators [Transcription]; Region: COG1733 688270001656 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 688270001657 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 688270001658 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 688270001659 active site 688270001660 metal binding site [ion binding]; metal-binding site 688270001661 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 688270001662 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 688270001663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270001664 active site 688270001665 phosphorylation site [posttranslational modification] 688270001666 intermolecular recognition site; other site 688270001667 dimerization interface [polypeptide binding]; other site 688270001668 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 688270001669 DNA binding residues [nucleotide binding] 688270001670 dimerization interface [polypeptide binding]; other site 688270001671 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 688270001672 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 688270001673 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 688270001674 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 688270001675 active site 688270001676 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 688270001677 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 688270001678 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 688270001679 Permease; Region: Permease; pfam02405 688270001680 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 688270001681 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 688270001682 Walker A/P-loop; other site 688270001683 ATP binding site [chemical binding]; other site 688270001684 Q-loop/lid; other site 688270001685 ABC transporter signature motif; other site 688270001686 Walker B; other site 688270001687 D-loop; other site 688270001688 H-loop/switch region; other site 688270001689 Major Facilitator Superfamily; Region: MFS_1; pfam07690 688270001690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 688270001691 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 688270001692 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 688270001693 Substrate binding site; other site 688270001694 Cupin domain; Region: Cupin_2; cl17218 688270001695 SprT homologues; Region: SprT; cl01182 688270001696 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 688270001697 classical (c) SDRs; Region: SDR_c; cd05233 688270001698 NAD(P) binding site [chemical binding]; other site 688270001699 active site 688270001700 M28 Zn-Peptidase IAP aminopeptidase may contain PA domain insert; Region: M28_like_5; cd08021 688270001701 Peptidase family M28; Region: Peptidase_M28; pfam04389 688270001702 metal binding site [ion binding]; metal-binding site 688270001703 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 688270001704 E3 interaction surface; other site 688270001705 lipoyl attachment site [posttranslational modification]; other site 688270001706 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 688270001707 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 688270001708 E3 interaction surface; other site 688270001709 lipoyl attachment site [posttranslational modification]; other site 688270001710 e3 binding domain; Region: E3_binding; pfam02817 688270001711 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 688270001712 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 688270001713 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 688270001714 tetramer interface [polypeptide binding]; other site 688270001715 TPP-binding site [chemical binding]; other site 688270001716 heterodimer interface [polypeptide binding]; other site 688270001717 phosphorylation loop region [posttranslational modification] 688270001718 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 688270001719 active site 688270001720 catalytic motif [active] 688270001721 Zn binding site [ion binding]; other site 688270001722 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 688270001723 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 688270001724 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 688270001725 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 688270001726 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 688270001727 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 688270001728 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 688270001729 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 688270001730 glycerol kinase; Provisional; Region: glpK; PRK00047 688270001731 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 688270001732 N- and C-terminal domain interface [polypeptide binding]; other site 688270001733 active site 688270001734 MgATP binding site [chemical binding]; other site 688270001735 catalytic site [active] 688270001736 metal binding site [ion binding]; metal-binding site 688270001737 glycerol binding site [chemical binding]; other site 688270001738 homotetramer interface [polypeptide binding]; other site 688270001739 homodimer interface [polypeptide binding]; other site 688270001740 FBP binding site [chemical binding]; other site 688270001741 protein IIAGlc interface [polypeptide binding]; other site 688270001742 putative transporter; Provisional; Region: PRK10484 688270001743 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 688270001744 Na binding site [ion binding]; other site 688270001745 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 688270001746 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 688270001747 Family description; Region: VCBS; pfam13517 688270001748 Family description; Region: VCBS; pfam13517 688270001749 Family description; Region: VCBS; pfam13517 688270001750 Family description; Region: VCBS; pfam13517 688270001751 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 688270001752 Family description; Region: VCBS; pfam13517 688270001753 Family description; Region: VCBS; pfam13517 688270001754 Family description; Region: VCBS; pfam13517 688270001755 starch binding outer membrane protein SusD; Region: SusD; cl17845 688270001756 SusD family; Region: SusD; pfam07980 688270001757 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270001758 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270001759 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 688270001760 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 688270001761 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 688270001762 DNA-binding site [nucleotide binding]; DNA binding site 688270001763 Transcriptional regulators [Transcription]; Region: PurR; COG1609 688270001764 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 688270001765 putative dimerization interface [polypeptide binding]; other site 688270001766 putative ligand binding site [chemical binding]; other site 688270001767 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 688270001768 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 688270001769 Gram-negative bacterial tonB protein; Region: TonB; cl10048 688270001770 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 688270001771 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 688270001772 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 688270001773 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 688270001774 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 688270001775 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 688270001776 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 688270001777 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 688270001778 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 688270001779 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 688270001780 active site 688270001781 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 688270001782 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 688270001783 active site 688270001784 dimer interface [polypeptide binding]; other site 688270001785 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 688270001786 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 688270001787 active site 688270001788 FMN binding site [chemical binding]; other site 688270001789 substrate binding site [chemical binding]; other site 688270001790 3Fe-4S cluster binding site [ion binding]; other site 688270001791 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 688270001792 domain interface; other site 688270001793 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 688270001794 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 688270001795 Domain of unknown function (DUF4302); Region: DUF4302; pfam14135 688270001796 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 688270001797 starch binding outer membrane protein SusD; Region: SusD; cl17845 688270001798 Secretin and TonB N terminus short domain; Region: STN; pfam07660 688270001799 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270001800 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270001801 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 688270001802 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270001803 FecR protein; Region: FecR; pfam04773 688270001804 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 688270001805 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 688270001806 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 688270001807 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270001808 DNA binding residues [nucleotide binding] 688270001809 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 688270001810 Family description; Region: VCBS; pfam13517 688270001811 Family description; Region: VCBS; pfam13517 688270001812 Family description; Region: VCBS; pfam13517 688270001813 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 688270001814 Family description; Region: VCBS; pfam13517 688270001815 Family description; Region: VCBS; pfam13517 688270001816 Family description; Region: VCBS; pfam13517 688270001817 Family description; Region: VCBS; pfam13517 688270001818 starch binding outer membrane protein SusD; Region: SusD; cl17845 688270001819 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270001820 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270001821 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 688270001822 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270001823 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 688270001824 RNA/DNA hybrid binding site [nucleotide binding]; other site 688270001825 active site 688270001826 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 688270001827 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 688270001828 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 688270001829 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 688270001830 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 688270001831 dimer interface [polypeptide binding]; other site 688270001832 putative anticodon binding site; other site 688270001833 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 688270001834 motif 1; other site 688270001835 active site 688270001836 motif 2; other site 688270001837 motif 3; other site 688270001838 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 688270001839 active site 688270001840 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 688270001841 beta-galactosidase; Region: BGL; TIGR03356 688270001842 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 688270001843 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 688270001844 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 688270001845 inhibitor-cofactor binding pocket; inhibition site 688270001846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270001847 catalytic residue [active] 688270001848 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 688270001849 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 688270001850 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 688270001851 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 688270001852 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 688270001853 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 688270001854 catalytic residue [active] 688270001855 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 688270001856 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 688270001857 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 688270001858 cofactor binding site; other site 688270001859 metal binding site [ion binding]; metal-binding site 688270001860 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 688270001861 GSCFA family; Region: GSCFA; pfam08885 688270001862 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 688270001863 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 688270001864 motif 1; other site 688270001865 active site 688270001866 motif 2; other site 688270001867 motif 3; other site 688270001868 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 688270001869 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 688270001870 Peptidase family M23; Region: Peptidase_M23; pfam01551 688270001871 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 688270001872 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 688270001873 DNA binding residues [nucleotide binding] 688270001874 LemA family; Region: LemA; cl00742 688270001875 Repair protein; Region: Repair_PSII; pfam04536 688270001876 Repair protein; Region: Repair_PSII; pfam04536 688270001877 GTP-binding protein Der; Reviewed; Region: PRK00093 688270001878 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 688270001879 G1 box; other site 688270001880 GTP/Mg2+ binding site [chemical binding]; other site 688270001881 Switch I region; other site 688270001882 G2 box; other site 688270001883 Switch II region; other site 688270001884 G3 box; other site 688270001885 G4 box; other site 688270001886 G5 box; other site 688270001887 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 688270001888 G1 box; other site 688270001889 GTP/Mg2+ binding site [chemical binding]; other site 688270001890 Switch I region; other site 688270001891 G2 box; other site 688270001892 G3 box; other site 688270001893 Switch II region; other site 688270001894 G4 box; other site 688270001895 G5 box; other site 688270001896 GTPase Era; Reviewed; Region: era; PRK00089 688270001897 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 688270001898 G1 box; other site 688270001899 GTP/Mg2+ binding site [chemical binding]; other site 688270001900 Switch I region; other site 688270001901 G2 box; other site 688270001902 Switch II region; other site 688270001903 G3 box; other site 688270001904 G4 box; other site 688270001905 G5 box; other site 688270001906 KH domain; Region: KH_2; pfam07650 688270001907 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 688270001908 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 688270001909 Protein of unknown function (DUF493); Region: DUF493; cl01102 688270001910 Staphylococcal nuclease homologues; Region: SNc; smart00318 688270001911 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 688270001912 Catalytic site; other site 688270001913 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 688270001914 catalytic motif [active] 688270001915 Catalytic residue [active] 688270001916 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 688270001917 Cell division protein FtsA; Region: FtsA; cl17206 688270001918 type IV secretion system ATPase VirB11; Provisional; Region: PRK13900 688270001919 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 688270001920 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 688270001921 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 688270001922 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 688270001923 Fic/DOC family; Region: Fic; pfam02661 688270001924 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 688270001925 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 688270001926 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 688270001927 ATP binding site [chemical binding]; other site 688270001928 putative Mg++ binding site [ion binding]; other site 688270001929 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 688270001930 non-specific DNA binding site [nucleotide binding]; other site 688270001931 salt bridge; other site 688270001932 sequence-specific DNA binding site [nucleotide binding]; other site 688270001933 HipA N-terminal domain; Region: Couple_hipA; pfam13657 688270001934 HipA-like N-terminal domain; Region: HipA_N; pfam07805 688270001935 HipA-like C-terminal domain; Region: HipA_C; pfam07804 688270001936 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 688270001937 GIY-YIG motif/motif A; other site 688270001938 putative active site [active] 688270001939 putative metal binding site [ion binding]; other site 688270001940 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 688270001941 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 688270001942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270001943 ATP binding site [chemical binding]; other site 688270001944 Mg2+ binding site [ion binding]; other site 688270001945 G-X-G motif; other site 688270001946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270001947 active site 688270001948 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 688270001949 phosphorylation site [posttranslational modification] 688270001950 intermolecular recognition site; other site 688270001951 dimerization interface [polypeptide binding]; other site 688270001952 Transcriptional regulators [Transcription]; Region: PurR; COG1609 688270001953 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 688270001954 DNA binding site [nucleotide binding] 688270001955 domain linker motif; other site 688270001956 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 688270001957 dimerization interface [polypeptide binding]; other site 688270001958 ligand binding site [chemical binding]; other site 688270001959 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 688270001960 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 688270001961 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 688270001962 inhibitor binding site; inhibition site 688270001963 active site 688270001964 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 688270001965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 688270001966 putative substrate translocation pore; other site 688270001967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 688270001968 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 688270001969 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 688270001970 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 688270001971 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 688270001972 PYR/PP interface [polypeptide binding]; other site 688270001973 dimer interface [polypeptide binding]; other site 688270001974 TPP binding site [chemical binding]; other site 688270001975 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 688270001976 transketolase; Reviewed; Region: PRK05899 688270001977 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 688270001978 TPP-binding site [chemical binding]; other site 688270001979 dimer interface [polypeptide binding]; other site 688270001980 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 688270001981 active site 688270001982 intersubunit interactions; other site 688270001983 catalytic residue [active] 688270001984 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 688270001985 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 688270001986 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 688270001987 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 688270001988 substrate binding site [chemical binding]; other site 688270001989 active site 688270001990 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 688270001991 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 688270001992 Family description; Region: VCBS; pfam13517 688270001993 Family description; Region: VCBS; pfam13517 688270001994 Family description; Region: VCBS; pfam13517 688270001995 Family description; Region: VCBS; pfam13517 688270001996 Family description; Region: VCBS; pfam13517 688270001997 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 688270001998 Family description; Region: VCBS; pfam13517 688270001999 Family description; Region: VCBS; pfam13517 688270002000 Family description; Region: VCBS; pfam13517 688270002001 Family description; Region: VCBS; pfam13517 688270002002 starch binding outer membrane protein SusD; Region: SusD; cd08977 688270002003 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270002004 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270002005 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 688270002006 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 688270002007 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 688270002008 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 688270002009 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270002010 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270002011 dimer interface [polypeptide binding]; other site 688270002012 phosphorylation site [posttranslational modification] 688270002013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270002014 ATP binding site [chemical binding]; other site 688270002015 Mg2+ binding site [ion binding]; other site 688270002016 G-X-G motif; other site 688270002017 Response regulator receiver domain; Region: Response_reg; pfam00072 688270002018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270002019 active site 688270002020 phosphorylation site [posttranslational modification] 688270002021 intermolecular recognition site; other site 688270002022 dimerization interface [polypeptide binding]; other site 688270002023 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 688270002024 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 688270002025 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 688270002026 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 688270002027 catalytic residues [active] 688270002028 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 688270002029 Helix-turn-helix domain; Region: HTH_18; pfam12833 688270002030 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 688270002031 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 688270002032 NADH(P)-binding; Region: NAD_binding_10; pfam13460 688270002033 NAD(P) binding site [chemical binding]; other site 688270002034 putative active site [active] 688270002035 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 688270002036 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 688270002037 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 688270002038 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 688270002039 HlyD family secretion protein; Region: HlyD_3; pfam13437 688270002040 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 688270002041 Leucine-rich repeats; other site 688270002042 Substrate binding site [chemical binding]; other site 688270002043 Leucine rich repeat; Region: LRR_8; pfam13855 688270002044 Leucine rich repeat; Region: LRR_8; pfam13855 688270002045 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 688270002046 Leucine rich repeat; Region: LRR_8; pfam13855 688270002047 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 688270002048 Leucine-rich repeats; other site 688270002049 Substrate binding site [chemical binding]; other site 688270002050 Leucine rich repeat; Region: LRR_8; pfam13855 688270002051 Leucine rich repeat; Region: LRR_8; pfam13855 688270002052 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 688270002053 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 688270002054 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 688270002055 ABC transporter; Region: ABC_tran_2; pfam12848 688270002056 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 688270002057 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 688270002058 gliding motility associated protien GldN; Region: GldN; TIGR03523 688270002059 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 688270002060 GldM N-terminal domain; Region: GldM_N; pfam12081 688270002061 GldM C-terminal domain; Region: GldM_C; pfam12080 688270002062 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 688270002063 gliding motility-associated lipoprotein GldK; Region: GldK; TIGR03525 688270002064 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 688270002065 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 688270002066 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 688270002067 putative active site [active] 688270002068 putative metal binding site [ion binding]; other site 688270002069 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 688270002070 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 688270002071 active site 688270002072 interdomain interaction site; other site 688270002073 putative metal-binding site [ion binding]; other site 688270002074 nucleotide binding site [chemical binding]; other site 688270002075 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 688270002076 domain I; other site 688270002077 DNA binding groove [nucleotide binding] 688270002078 phosphate binding site [ion binding]; other site 688270002079 domain II; other site 688270002080 domain III; other site 688270002081 nucleotide binding site [chemical binding]; other site 688270002082 catalytic site [active] 688270002083 domain IV; other site 688270002084 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 688270002085 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 688270002086 Uncharacterized conserved protein [Function unknown]; Region: COG5276 688270002087 Methyltransferase domain; Region: Methyltransf_12; pfam08242 688270002088 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 688270002089 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 688270002090 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 688270002091 FeS/SAM binding site; other site 688270002092 TRAM domain; Region: TRAM; pfam01938 688270002093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 688270002094 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 688270002095 Walker A motif; other site 688270002096 ATP binding site [chemical binding]; other site 688270002097 Walker B motif; other site 688270002098 arginine finger; other site 688270002099 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 688270002100 Lipopolysaccharide-assembly; Region: LptE; pfam04390 688270002101 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 688270002102 oligomerisation interface [polypeptide binding]; other site 688270002103 mobile loop; other site 688270002104 roof hairpin; other site 688270002105 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 688270002106 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 688270002107 ring oligomerisation interface [polypeptide binding]; other site 688270002108 ATP/Mg binding site [chemical binding]; other site 688270002109 stacking interactions; other site 688270002110 hinge regions; other site 688270002111 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 688270002112 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 688270002113 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 688270002114 Heavy-metal-associated domain; Region: HMA; pfam00403 688270002115 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270002116 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270002117 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 688270002118 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 688270002119 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 688270002120 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 688270002121 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 688270002122 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 688270002123 purine monophosphate binding site [chemical binding]; other site 688270002124 dimer interface [polypeptide binding]; other site 688270002125 putative catalytic residues [active] 688270002126 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 688270002127 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 688270002128 rod shape-determining protein MreB; Provisional; Region: PRK13927 688270002129 MreB and similar proteins; Region: MreB_like; cd10225 688270002130 nucleotide binding site [chemical binding]; other site 688270002131 Mg binding site [ion binding]; other site 688270002132 putative protofilament interaction site [polypeptide binding]; other site 688270002133 RodZ interaction site [polypeptide binding]; other site 688270002134 rod shape-determining protein MreC; Provisional; Region: PRK13922 688270002135 rod shape-determining protein MreC; Region: MreC; pfam04085 688270002136 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 688270002137 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 688270002138 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 688270002139 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 688270002140 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 688270002141 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 688270002142 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 688270002143 active site 688270002144 substrate binding site [chemical binding]; other site 688270002145 Mg2+ binding site [ion binding]; other site 688270002146 Uncharacterized conserved protein [Function unknown]; Region: COG0397 688270002147 hypothetical protein; Validated; Region: PRK00029 688270002148 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 688270002149 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 688270002150 protein binding site [polypeptide binding]; other site 688270002151 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 688270002152 Catalytic dyad [active] 688270002153 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 688270002154 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 688270002155 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 688270002156 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 688270002157 NlpC/P60 family; Region: NLPC_P60; pfam00877 688270002158 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 688270002159 Competence protein; Region: Competence; pfam03772 688270002160 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 688270002161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 688270002162 putative substrate translocation pore; other site 688270002163 POT family; Region: PTR2; cl17359 688270002164 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 688270002165 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 688270002166 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 688270002167 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 688270002168 homodimer interface [polypeptide binding]; other site 688270002169 catalytic residues [active] 688270002170 NAD binding site [chemical binding]; other site 688270002171 substrate binding pocket [chemical binding]; other site 688270002172 flexible flap; other site 688270002173 SurA N-terminal domain; Region: SurA_N_3; cl07813 688270002174 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 688270002175 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 688270002176 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 688270002177 Domain of unknown function DUF21; Region: DUF21; pfam01595 688270002178 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 688270002179 Transporter associated domain; Region: CorC_HlyC; smart01091 688270002180 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 688270002181 pantothenate kinase; Reviewed; Region: PRK13320 688270002182 Family description; Region: VCBS; pfam13517 688270002183 Family description; Region: VCBS; pfam13517 688270002184 Family description; Region: VCBS; pfam13517 688270002185 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 688270002186 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 688270002187 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 688270002188 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270002189 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270002190 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 688270002191 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270002192 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 688270002193 starch binding outer membrane protein SusD; Region: SusD; cl17845 688270002194 SusD family; Region: SusD; pfam07980 688270002195 Fasciclin domain; Region: Fasciclin; pfam02469 688270002196 Fasciclin domain; Region: Fasciclin; pfam02469 688270002197 Fasciclin domain; Region: Fasciclin; cl02663 688270002198 Family description; Region: VCBS; pfam13517 688270002199 Family description; Region: VCBS; pfam13517 688270002200 Family description; Region: VCBS; pfam13517 688270002201 Family description; Region: VCBS; pfam13517 688270002202 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 688270002203 Family description; Region: VCBS; pfam13517 688270002204 Family description; Region: VCBS; pfam13517 688270002205 Family description; Region: VCBS; pfam13517 688270002206 Family description; Region: VCBS; pfam13517 688270002207 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 688270002208 active site residue [active] 688270002209 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 688270002210 purine nucleoside phosphorylase; Provisional; Region: PRK08202 688270002211 Protein of unknown function, DUF547; Region: DUF547; pfam04784 688270002212 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 688270002213 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 688270002214 Probable Catalytic site; other site 688270002215 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 688270002216 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 688270002217 active site 688270002218 metal binding site [ion binding]; metal-binding site 688270002219 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 688270002220 Surface antigen; Region: Bac_surface_Ag; pfam01103 688270002221 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 688270002222 Protein of unknown function, DUF547; Region: DUF547; pfam04784 688270002223 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 688270002224 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 688270002225 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 688270002226 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 688270002227 4Fe-4S binding domain; Region: Fer4_5; pfam12801 688270002228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 688270002229 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 688270002230 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 688270002231 Ligand binding site; other site 688270002232 Putative Catalytic site; other site 688270002233 DXD motif; other site 688270002234 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 688270002235 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 688270002236 DXD motif; other site 688270002237 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 688270002238 Coenzyme A binding pocket [chemical binding]; other site 688270002239 argininosuccinate synthase; Provisional; Region: PRK13820 688270002240 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 688270002241 Ligand Binding Site [chemical binding]; other site 688270002242 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 688270002243 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 688270002244 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 688270002245 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 688270002246 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 688270002247 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 688270002248 inhibitor-cofactor binding pocket; inhibition site 688270002249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270002250 catalytic residue [active] 688270002251 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 688270002252 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 688270002253 putative catalytic cysteine [active] 688270002254 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 688270002255 nucleotide binding site [chemical binding]; other site 688270002256 homotetrameric interface [polypeptide binding]; other site 688270002257 putative phosphate binding site [ion binding]; other site 688270002258 putative allosteric binding site; other site 688270002259 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 688270002260 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 688270002261 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 688270002262 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 688270002263 nucleotide binding site [chemical binding]; other site 688270002264 N-acetyl-L-glutamate binding site [chemical binding]; other site 688270002265 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 688270002266 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 688270002267 metal binding site [ion binding]; metal-binding site 688270002268 dimer interface [polypeptide binding]; other site 688270002269 Lyase; Region: Lyase_1; pfam00206 688270002270 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 688270002271 active sites [active] 688270002272 tetramer interface [polypeptide binding]; other site 688270002273 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 688270002274 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 688270002275 RNA binding surface [nucleotide binding]; other site 688270002276 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 688270002277 active site 688270002278 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 688270002279 Predicted amidohydrolase [General function prediction only]; Region: COG0388 688270002280 putative active site [active] 688270002281 catalytic triad [active] 688270002282 putative dimer interface [polypeptide binding]; other site 688270002283 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 688270002284 UbiA prenyltransferase family; Region: UbiA; pfam01040 688270002285 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 688270002286 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 688270002287 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 688270002288 diphosphomevalonate decarboxylase; Region: PLN02407 688270002289 TspO/MBR family; Region: TspO_MBR; pfam03073 688270002290 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 688270002291 flavoprotein, HI0933 family; Region: TIGR00275 688270002292 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 688270002293 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 688270002294 active site 688270002295 catalytic site [active] 688270002296 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 688270002297 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349 688270002298 active site 688270002299 catalytic site [active] 688270002300 maltose phosphorylase; Provisional; Region: PRK13807 688270002301 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 688270002302 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 688270002303 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 688270002304 beta-phosphoglucomutase; Region: bPGM; TIGR01990 688270002305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 688270002306 Transcriptional regulators [Transcription]; Region: PurR; COG1609 688270002307 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 688270002308 DNA binding site [nucleotide binding] 688270002309 domain linker motif; other site 688270002310 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 688270002311 dimerization interface [polypeptide binding]; other site 688270002312 ligand binding site [chemical binding]; other site 688270002313 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270002314 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270002315 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 688270002316 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270002317 starch binding outer membrane protein SusD; Region: SusD; cl17845 688270002318 SusD family; Region: SusD; pfam07980 688270002319 Family description; Region: VCBS; pfam13517 688270002320 Family description; Region: VCBS; pfam13517 688270002321 Family description; Region: VCBS; pfam13517 688270002322 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 688270002323 Family description; Region: VCBS; pfam13517 688270002324 Family description; Region: VCBS; pfam13517 688270002325 Family description; Region: VCBS; pfam13517 688270002326 Family description; Region: VCBS; pfam13517 688270002327 Family description; Region: VCBS; pfam13517 688270002328 Family description; Region: VCBS; pfam13517 688270002329 Family description; Region: VCBS; pfam13517 688270002330 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 688270002331 Family description; Region: VCBS; pfam13517 688270002332 Family description; Region: VCBS; pfam13517 688270002333 Family description; Region: VCBS; pfam13517 688270002334 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 688270002335 active site 688270002336 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 688270002337 putative transporter; Provisional; Region: PRK10484 688270002338 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 688270002339 Na binding site [ion binding]; other site 688270002340 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 688270002341 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 688270002342 active site 688270002343 metal binding site [ion binding]; metal-binding site 688270002344 Surface antigen; Region: Bac_surface_Ag; pfam01103 688270002345 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 688270002346 Zn2+ binding site [ion binding]; other site 688270002347 Mg2+ binding site [ion binding]; other site 688270002348 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270002349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270002350 dimer interface [polypeptide binding]; other site 688270002351 phosphorylation site [posttranslational modification] 688270002352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270002353 ATP binding site [chemical binding]; other site 688270002354 Mg2+ binding site [ion binding]; other site 688270002355 G-X-G motif; other site 688270002356 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 688270002357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270002358 active site 688270002359 phosphorylation site [posttranslational modification] 688270002360 intermolecular recognition site; other site 688270002361 dimerization interface [polypeptide binding]; other site 688270002362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 688270002363 Walker A motif; other site 688270002364 ATP binding site [chemical binding]; other site 688270002365 Walker B motif; other site 688270002366 arginine finger; other site 688270002367 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 688270002368 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 688270002369 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 688270002370 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 688270002371 NAD(P) binding site [chemical binding]; other site 688270002372 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 688270002373 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 688270002374 putative active site [active] 688270002375 putative metal binding site [ion binding]; other site 688270002376 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 688270002377 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 688270002378 Surface antigen; Region: Bac_surface_Ag; pfam01103 688270002379 Penicillin amidase; Region: Penicil_amidase; pfam01804 688270002380 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 688270002381 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 688270002382 active site 688270002383 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 688270002384 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 688270002385 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 688270002386 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 688270002387 Walker A/P-loop; other site 688270002388 ATP binding site [chemical binding]; other site 688270002389 Q-loop/lid; other site 688270002390 ABC transporter signature motif; other site 688270002391 Walker B; other site 688270002392 D-loop; other site 688270002393 H-loop/switch region; other site 688270002394 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 688270002395 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 688270002396 NifU-like domain; Region: NifU; cl00484 688270002397 Domain of unknown function DUF59; Region: DUF59; pfam01883 688270002398 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 688270002399 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 688270002400 Walker A motif; other site 688270002401 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 688270002402 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 688270002403 DNA binding site [nucleotide binding] 688270002404 active site 688270002405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 688270002406 S-adenosylmethionine binding site [chemical binding]; other site 688270002407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270002408 dimer interface [polypeptide binding]; other site 688270002409 phosphorylation site [posttranslational modification] 688270002410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270002411 ATP binding site [chemical binding]; other site 688270002412 Mg2+ binding site [ion binding]; other site 688270002413 G-X-G motif; other site 688270002414 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 688270002415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270002416 active site 688270002417 phosphorylation site [posttranslational modification] 688270002418 intermolecular recognition site; other site 688270002419 dimerization interface [polypeptide binding]; other site 688270002420 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 688270002421 DNA binding site [nucleotide binding] 688270002422 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 688270002423 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 688270002424 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270002425 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 688270002426 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 688270002427 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 688270002428 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 688270002429 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 688270002430 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 688270002431 active site 688270002432 HIGH motif; other site 688270002433 dimer interface [polypeptide binding]; other site 688270002434 KMSKS motif; other site 688270002435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270002436 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 688270002437 NAD(P) binding site [chemical binding]; other site 688270002438 active site 688270002439 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 688270002440 dihydroorotase; Reviewed; Region: PRK09236 688270002441 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 688270002442 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 688270002443 active site 688270002444 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 688270002445 Ligand binding site; other site 688270002446 Putative Catalytic site; other site 688270002447 DXD motif; other site 688270002448 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 688270002449 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 688270002450 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 688270002451 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 688270002452 active site 688270002453 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 688270002454 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 688270002455 active site 688270002456 substrate-binding site [chemical binding]; other site 688270002457 metal-binding site [ion binding] 688270002458 ATP binding site [chemical binding]; other site 688270002459 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 688270002460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270002461 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 688270002462 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 688270002463 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 688270002464 putative DNA binding site [nucleotide binding]; other site 688270002465 putative Zn2+ binding site [ion binding]; other site 688270002466 AsnC family; Region: AsnC_trans_reg; pfam01037 688270002467 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 688270002468 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 688270002469 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 688270002470 hexamer interface [polypeptide binding]; other site 688270002471 ligand binding site [chemical binding]; other site 688270002472 putative active site [active] 688270002473 NAD(P) binding site [chemical binding]; other site 688270002474 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 688270002475 active site 688270002476 HIGH motif; other site 688270002477 nucleotide binding site [chemical binding]; other site 688270002478 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 688270002479 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 688270002480 putative active site [active] 688270002481 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 688270002482 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 688270002483 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 688270002484 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 688270002485 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 688270002486 active site 688270002487 KMSKS motif; other site 688270002488 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 688270002489 tRNA binding surface [nucleotide binding]; other site 688270002490 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 688270002491 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 688270002492 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 688270002493 Bacitracin resistance protein BacA; Region: BacA; pfam02673 688270002494 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 688270002495 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 688270002496 RNA binding site [nucleotide binding]; other site 688270002497 active site 688270002498 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 688270002499 Thioredoxin (TRX) superfamily; a large, diverse group of proteins containing a TRX-fold. Many members contain a classic TRX domain with a redox active CXXC motif. They function as protein disulfide oxidoreductases (PDOs), altering the redox state of...; Region: TRX_superfamily; cd01659 688270002500 Uncharacterized conserved protein [Function unknown]; Region: COG1284 688270002501 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 688270002502 Outer membrane efflux protein; Region: OEP; pfam02321 688270002503 Outer membrane efflux protein; Region: OEP; pfam02321 688270002504 HlyD family secretion protein; Region: HlyD; pfam00529 688270002505 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 688270002506 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 688270002507 HlyD family secretion protein; Region: HlyD_3; pfam13437 688270002508 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 688270002509 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 688270002510 Walker A/P-loop; other site 688270002511 ATP binding site [chemical binding]; other site 688270002512 Q-loop/lid; other site 688270002513 ABC transporter signature motif; other site 688270002514 Walker B; other site 688270002515 D-loop; other site 688270002516 H-loop/switch region; other site 688270002517 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 688270002518 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 688270002519 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 688270002520 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 688270002521 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 688270002522 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 688270002523 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 688270002524 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 688270002525 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270002526 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270002527 phosphorylation site [posttranslational modification] 688270002528 dimer interface [polypeptide binding]; other site 688270002529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270002530 ATP binding site [chemical binding]; other site 688270002531 Mg2+ binding site [ion binding]; other site 688270002532 G-X-G motif; other site 688270002533 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 688270002534 nucleotide binding site/active site [active] 688270002535 HIT family signature motif; other site 688270002536 catalytic residue [active] 688270002537 Sensors of blue-light using FAD; Region: BLUF; pfam04940 688270002538 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 688270002539 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 688270002540 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 688270002541 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 688270002542 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 688270002543 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 688270002544 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 688270002545 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270002546 GLPGLI family protein; Region: GLPGLI; TIGR01200 688270002547 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270002548 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270002549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270002550 dimer interface [polypeptide binding]; other site 688270002551 phosphorylation site [posttranslational modification] 688270002552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270002553 ATP binding site [chemical binding]; other site 688270002554 Mg2+ binding site [ion binding]; other site 688270002555 G-X-G motif; other site 688270002556 Response regulator receiver domain; Region: Response_reg; pfam00072 688270002557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270002558 active site 688270002559 phosphorylation site [posttranslational modification] 688270002560 intermolecular recognition site; other site 688270002561 dimerization interface [polypeptide binding]; other site 688270002562 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 688270002563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270002564 active site 688270002565 phosphorylation site [posttranslational modification] 688270002566 intermolecular recognition site; other site 688270002567 dimerization interface [polypeptide binding]; other site 688270002568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 688270002569 Walker A motif; other site 688270002570 ATP binding site [chemical binding]; other site 688270002571 Walker B motif; other site 688270002572 arginine finger; other site 688270002573 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 688270002574 Protein of unknown function (DUF3316); Region: DUF3316; pfam11777 688270002575 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 688270002576 Protein of unknown function (DUF3316); Region: DUF3316; pfam11777 688270002577 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 688270002578 Protein of unknown function (DUF3316); Region: DUF3316; pfam11777 688270002579 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 688270002580 Protein of unknown function (DUF3316); Region: DUF3316; pfam11777 688270002581 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 688270002582 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 688270002583 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 688270002584 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 688270002585 AAA domain; Region: AAA_28; pfam13521 688270002586 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 688270002587 Domain of unknown function DUF77; Region: DUF77; cl00307 688270002588 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 688270002589 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 688270002590 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 688270002591 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 688270002592 homotetramer interface [polypeptide binding]; other site 688270002593 ligand binding site [chemical binding]; other site 688270002594 catalytic site [active] 688270002595 NAD binding site [chemical binding]; other site 688270002596 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270002597 NAD(P) binding site [chemical binding]; other site 688270002598 active site 688270002599 Phytase; Region: Phytase; cl17685 688270002600 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 688270002601 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 688270002602 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270002603 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270002604 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 688270002605 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 688270002606 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 688270002607 Uncharacterized conserved protein [Function unknown]; Region: COG3743 688270002608 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 688270002609 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 688270002610 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 688270002611 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 688270002612 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 688270002613 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 688270002614 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 688270002615 gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512 688270002616 Domain of unknown function DUF21; Region: DUF21; pfam01595 688270002617 gliding motility-associated protein GldE; Region: GldE; TIGR03520 688270002618 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 688270002619 Transporter associated domain; Region: CorC_HlyC; smart01091 688270002620 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 688270002621 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 688270002622 dimer interface [polypeptide binding]; other site 688270002623 ssDNA binding site [nucleotide binding]; other site 688270002624 tetramer (dimer of dimers) interface [polypeptide binding]; other site 688270002625 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 688270002626 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 688270002627 minor groove reading motif; other site 688270002628 helix-hairpin-helix signature motif; other site 688270002629 substrate binding pocket [chemical binding]; other site 688270002630 active site 688270002631 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 688270002632 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 688270002633 DNA binding and oxoG recognition site [nucleotide binding] 688270002634 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 688270002635 IHF dimer interface [polypeptide binding]; other site 688270002636 IHF - DNA interface [nucleotide binding]; other site 688270002637 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 688270002638 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 688270002639 homodimer interface [polypeptide binding]; other site 688270002640 oligonucleotide binding site [chemical binding]; other site 688270002641 RecX family; Region: RecX; pfam02631 688270002642 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 688270002643 Cupin-like domain; Region: Cupin_8; pfam13621 688270002644 biotin synthase; Region: bioB; TIGR00433 688270002645 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 688270002646 FeS/SAM binding site; other site 688270002647 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 688270002648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 688270002649 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 688270002650 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 688270002651 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 688270002652 active site 688270002653 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 688270002654 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 688270002655 inhibitor-cofactor binding pocket; inhibition site 688270002656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270002657 catalytic residue [active] 688270002658 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 688270002659 AAA domain; Region: AAA_26; pfam13500 688270002660 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 688270002661 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 688270002662 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 688270002663 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 688270002664 catalytic residue [active] 688270002665 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 688270002666 Interdomain contacts; other site 688270002667 Cytokine receptor motif; other site 688270002668 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 688270002669 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 688270002670 putative active site [active] 688270002671 Fibronectin type 3 domain; Region: FN3; smart00060 688270002672 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 688270002673 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 688270002674 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 688270002675 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 688270002676 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 688270002677 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 688270002678 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 688270002679 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 688270002680 Zn binding site [ion binding]; other site 688270002681 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 688270002682 Transcription antiterminator [Transcription]; Region: NusG; COG0250 688270002683 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 688270002684 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 688270002685 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 688270002686 NADP-binding site; other site 688270002687 homotetramer interface [polypeptide binding]; other site 688270002688 substrate binding site [chemical binding]; other site 688270002689 homodimer interface [polypeptide binding]; other site 688270002690 active site 688270002691 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 688270002692 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 688270002693 NADP binding site [chemical binding]; other site 688270002694 active site 688270002695 putative substrate binding site [chemical binding]; other site 688270002696 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 688270002697 Bacterial sugar transferase; Region: Bac_transf; pfam02397 688270002698 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 688270002699 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 688270002700 AAA domain; Region: AAA_31; pfam13614 688270002701 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 688270002702 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 688270002703 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 688270002704 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 688270002705 putative trimer interface [polypeptide binding]; other site 688270002706 putative CoA binding site [chemical binding]; other site 688270002707 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 688270002708 Acyltransferase family; Region: Acyl_transf_3; pfam01757 688270002709 VanZ like family; Region: VanZ; cl01971 688270002710 putative glycosyl transferase; Provisional; Region: PRK10307 688270002711 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 688270002712 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 688270002713 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 688270002714 acyl-activating enzyme (AAE) consensus motif; other site 688270002715 active site 688270002716 AMP binding site [chemical binding]; other site 688270002717 CoA binding site [chemical binding]; other site 688270002718 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397 688270002719 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 688270002720 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 688270002721 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 688270002722 trimer interface [polypeptide binding]; other site 688270002723 active site 688270002724 substrate binding site [chemical binding]; other site 688270002725 CoA binding site [chemical binding]; other site 688270002726 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 688270002727 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 688270002728 putative ADP-binding pocket [chemical binding]; other site 688270002729 putative acyl transferase; Provisional; Region: PRK10502 688270002730 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 688270002731 putative trimer interface [polypeptide binding]; other site 688270002732 putative active site [active] 688270002733 putative substrate binding site [chemical binding]; other site 688270002734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 688270002735 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 688270002736 gamma subunit interface [polypeptide binding]; other site 688270002737 LBP interface [polypeptide binding]; other site 688270002738 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 688270002739 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 688270002740 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 688270002741 alpha subunit interaction interface [polypeptide binding]; other site 688270002742 Walker A motif; other site 688270002743 ATP binding site [chemical binding]; other site 688270002744 Walker B motif; other site 688270002745 inhibitor binding site; inhibition site 688270002746 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 688270002747 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 688270002748 catalytic triad [active] 688270002749 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270002750 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 688270002751 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 688270002752 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270002753 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270002754 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 688270002755 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 688270002756 glutaminase active site [active] 688270002757 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 688270002758 dimer interface [polypeptide binding]; other site 688270002759 active site 688270002760 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 688270002761 dimer interface [polypeptide binding]; other site 688270002762 active site 688270002763 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 688270002764 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 688270002765 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 688270002766 pantoate--beta-alanine ligase; Region: panC; TIGR00018 688270002767 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 688270002768 active site 688270002769 nucleotide binding site [chemical binding]; other site 688270002770 HIGH motif; other site 688270002771 KMSKS motif; other site 688270002772 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 688270002773 tetramerization interface [polypeptide binding]; other site 688270002774 active site 688270002775 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 688270002776 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 688270002777 DNA repair protein RadA; Provisional; Region: PRK11823 688270002778 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 688270002779 Walker A motif/ATP binding site; other site 688270002780 ATP binding site [chemical binding]; other site 688270002781 Walker B motif; other site 688270002782 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 688270002783 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 688270002784 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 688270002785 active site 688270002786 catalytic tetrad [active] 688270002787 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 688270002788 putative active site [active] 688270002789 putative catalytic site [active] 688270002790 putative DNA binding site [nucleotide binding]; other site 688270002791 putative phosphate binding site [ion binding]; other site 688270002792 metal binding site A [ion binding]; metal-binding site 688270002793 putative AP binding site [nucleotide binding]; other site 688270002794 putative metal binding site B [ion binding]; other site 688270002795 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 688270002796 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 688270002797 ligand binding site [chemical binding]; other site 688270002798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 688270002799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 688270002800 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 688270002801 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 688270002802 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 688270002803 heme binding site [chemical binding]; other site 688270002804 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 688270002805 glycyl-tRNA synthetase; Provisional; Region: PRK04173 688270002806 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 688270002807 motif 1; other site 688270002808 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 688270002809 active site 688270002810 motif 2; other site 688270002811 motif 3; other site 688270002812 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 688270002813 anticodon binding site; other site 688270002814 phosphodiesterase; Provisional; Region: PRK12704 688270002815 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 688270002816 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 688270002817 active site 688270002818 Bacterial Ig-like domain; Region: Big_5; pfam13205 688270002819 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930 688270002820 C-N hydrolase family amidase; Provisional; Region: PRK10438 688270002821 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 688270002822 putative active site [active] 688270002823 catalytic triad [active] 688270002824 dimer interface [polypeptide binding]; other site 688270002825 multimer interface [polypeptide binding]; other site 688270002826 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 688270002827 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 688270002828 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270002829 PAS fold; Region: PAS_3; pfam08447 688270002830 putative active site [active] 688270002831 heme pocket [chemical binding]; other site 688270002832 PAS domain S-box; Region: sensory_box; TIGR00229 688270002833 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270002834 putative active site [active] 688270002835 heme pocket [chemical binding]; other site 688270002836 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270002837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270002838 ATP binding site [chemical binding]; other site 688270002839 Mg2+ binding site [ion binding]; other site 688270002840 G-X-G motif; other site 688270002841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270002842 Response regulator receiver domain; Region: Response_reg; pfam00072 688270002843 active site 688270002844 phosphorylation site [posttranslational modification] 688270002845 intermolecular recognition site; other site 688270002846 dimerization interface [polypeptide binding]; other site 688270002847 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 688270002848 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270002849 putative active site [active] 688270002850 heme pocket [chemical binding]; other site 688270002851 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270002852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270002853 dimer interface [polypeptide binding]; other site 688270002854 phosphorylation site [posttranslational modification] 688270002855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270002856 ATP binding site [chemical binding]; other site 688270002857 Mg2+ binding site [ion binding]; other site 688270002858 G-X-G motif; other site 688270002859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270002860 Response regulator receiver domain; Region: Response_reg; pfam00072 688270002861 active site 688270002862 phosphorylation site [posttranslational modification] 688270002863 intermolecular recognition site; other site 688270002864 dimerization interface [polypeptide binding]; other site 688270002865 Lamin Tail Domain; Region: LTD; pfam00932 688270002866 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270002867 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270002868 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270002869 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 688270002870 putative catalytic site [active] 688270002871 putative metal binding site [ion binding]; other site 688270002872 putative phosphate binding site [ion binding]; other site 688270002873 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 688270002874 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 688270002875 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 688270002876 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 688270002877 active site 688270002878 dimer interface [polypeptide binding]; other site 688270002879 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 688270002880 dimer interface [polypeptide binding]; other site 688270002881 active site 688270002882 putative peptidase; Provisional; Region: PRK11649 688270002883 Peptidase family M23; Region: Peptidase_M23; pfam01551 688270002884 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 688270002885 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 688270002886 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 688270002887 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 688270002888 dimer interface [polypeptide binding]; other site 688270002889 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 688270002890 active site 688270002891 Fe binding site [ion binding]; other site 688270002892 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 688270002893 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 688270002894 active site 688270002895 nucleophile elbow; other site 688270002896 Surface antigen; Region: Bac_surface_Ag; pfam01103 688270002897 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 688270002898 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 688270002899 GIY-YIG motif/motif A; other site 688270002900 active site 688270002901 catalytic site [active] 688270002902 putative DNA binding site [nucleotide binding]; other site 688270002903 metal binding site [ion binding]; metal-binding site 688270002904 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 688270002905 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 688270002906 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 688270002907 lipoprotein signal peptidase; Provisional; Region: PRK14788 688270002908 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 688270002909 isoleucyl-tRNA synthetase; Region: ileS; TIGR00392 688270002910 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 688270002911 HIGH motif; other site 688270002912 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 688270002913 active site 688270002914 KMSKS motif; other site 688270002915 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 688270002916 tRNA binding surface [nucleotide binding]; other site 688270002917 anticodon binding site; other site 688270002918 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270002919 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 688270002920 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 688270002921 N-terminal plug; other site 688270002922 ligand-binding site [chemical binding]; other site 688270002923 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 688270002924 Recombination protein O N terminal; Region: RecO_N; pfam11967 688270002925 Recombination protein O C terminal; Region: RecO_C; pfam02565 688270002926 glutamate dehydrogenase; Provisional; Region: PRK09414 688270002927 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 688270002928 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 688270002929 NAD(P) binding site [chemical binding]; other site 688270002930 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 688270002931 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 688270002932 homodimer interface [polypeptide binding]; other site 688270002933 substrate-cofactor binding pocket; other site 688270002934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270002935 catalytic residue [active] 688270002936 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 688270002937 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 688270002938 DinB superfamily; Region: DinB_2; pfam12867 688270002939 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 688270002940 ArsC family; Region: ArsC; pfam03960 688270002941 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 688270002942 EamA-like transporter family; Region: EamA; pfam00892 688270002943 EamA-like transporter family; Region: EamA; pfam00892 688270002944 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 688270002945 active site 688270002946 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 688270002947 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 688270002948 FMN binding site [chemical binding]; other site 688270002949 substrate binding site [chemical binding]; other site 688270002950 putative catalytic residue [active] 688270002951 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 688270002952 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 688270002953 Cytochrome c; Region: Cytochrom_C; pfam00034 688270002954 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 688270002955 dimer interface [polypeptide binding]; other site 688270002956 substrate binding site [chemical binding]; other site 688270002957 ATP binding site [chemical binding]; other site 688270002958 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 688270002959 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 688270002960 Sulfate transporter family; Region: Sulfate_transp; pfam00916 688270002961 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 688270002962 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 688270002963 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 688270002964 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 688270002965 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 688270002966 Transglycosylase; Region: Transgly; pfam00912 688270002967 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 688270002968 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 688270002969 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 688270002970 Colicin V production protein; Region: Colicin_V; pfam02674 688270002971 MG2 domain; Region: A2M_N; pfam01835 688270002972 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 688270002973 Alpha-2-macroglobulin family; Region: A2M; pfam00207 688270002974 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 688270002975 surface patch; other site 688270002976 thioester region; other site 688270002977 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 688270002978 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 688270002979 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 688270002980 aldehyde dehydrogenase family 7 member; Region: PLN02315 688270002981 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 688270002982 tetrameric interface [polypeptide binding]; other site 688270002983 NAD binding site [chemical binding]; other site 688270002984 catalytic residues [active] 688270002985 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 688270002986 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 688270002987 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 688270002988 ligand binding site [chemical binding]; other site 688270002989 Uncharacterized conserved protein [Function unknown]; Region: COG3743 688270002990 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 688270002991 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 688270002992 homodimer interface [polypeptide binding]; other site 688270002993 putative substrate binding pocket [chemical binding]; other site 688270002994 diiron center [ion binding]; other site 688270002995 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 688270002996 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 688270002997 active site 688270002998 metal binding site [ion binding]; metal-binding site 688270002999 DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874 688270003000 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 688270003001 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 688270003002 Divergent AAA domain; Region: AAA_4; pfam04326 688270003003 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 688270003004 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270003005 NAD(P) binding site [chemical binding]; other site 688270003006 active site 688270003007 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 688270003008 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 688270003009 active site 688270003010 catalytic tetrad [active] 688270003011 MoxR-like ATPases [General function prediction only]; Region: COG0714 688270003012 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 688270003013 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 688270003014 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 688270003015 metal ion-dependent adhesion site (MIDAS); other site 688270003016 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 688270003017 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 688270003018 metal ion-dependent adhesion site (MIDAS); other site 688270003019 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 688270003020 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 688270003021 metal ion-dependent adhesion site (MIDAS); other site 688270003022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270003023 TPR motif; other site 688270003024 binding surface 688270003025 TPR repeat; Region: TPR_11; pfam13414 688270003026 Oxygen tolerance; Region: BatD; pfam13584 688270003027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270003028 binding surface 688270003029 Tetratricopeptide repeat; Region: TPR_16; pfam13432 688270003030 TPR motif; other site 688270003031 Bacterial SH3 domain; Region: SH3_3; pfam08239 688270003032 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 688270003033 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 688270003034 Sulfate transporter family; Region: Sulfate_transp; pfam00916 688270003035 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 688270003036 active site clefts [active] 688270003037 zinc binding site [ion binding]; other site 688270003038 dimer interface [polypeptide binding]; other site 688270003039 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 688270003040 active site clefts [active] 688270003041 zinc binding site [ion binding]; other site 688270003042 dimer interface [polypeptide binding]; other site 688270003043 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 688270003044 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 688270003045 Sulfate transporter family; Region: Sulfate_transp; pfam00916 688270003046 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 688270003047 Sulfate transporter family; Region: Sulfate_transp; pfam00916 688270003048 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 688270003049 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 688270003050 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 688270003051 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 688270003052 dimer interface [polypeptide binding]; other site 688270003053 motif 1; other site 688270003054 active site 688270003055 motif 2; other site 688270003056 motif 3; other site 688270003057 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 688270003058 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 688270003059 HlyD family secretion protein; Region: HlyD_3; pfam13437 688270003060 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 688270003061 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 688270003062 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 688270003063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 688270003064 Abi-like protein; Region: Abi_2; pfam07751 688270003065 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 688270003066 putative active site [active] 688270003067 putative metal binding residues [ion binding]; other site 688270003068 signature motif; other site 688270003069 putative dimer interface [polypeptide binding]; other site 688270003070 putative phosphate binding site [ion binding]; other site 688270003071 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 688270003072 NAD binding site [chemical binding]; other site 688270003073 active site 688270003074 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 688270003075 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 688270003076 active site 688270003077 DNA polymerase IV; Validated; Region: PRK02406 688270003078 DNA binding site [nucleotide binding] 688270003079 Uncharacterized conserved protein [Function unknown]; Region: COG2128 688270003080 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 688270003081 Helix-turn-helix domain; Region: HTH_18; pfam12833 688270003082 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 688270003083 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 688270003084 domain interfaces; other site 688270003085 active site 688270003086 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 688270003087 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 688270003088 dimerization interface [polypeptide binding]; other site 688270003089 active site 688270003090 metal binding site [ion binding]; metal-binding site 688270003091 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 688270003092 dsRNA binding site [nucleotide binding]; other site 688270003093 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 688270003094 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 688270003095 dimer interface [polypeptide binding]; other site 688270003096 active site 688270003097 acyl carrier protein; Provisional; Region: acpP; PRK00982 688270003098 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 688270003099 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 688270003100 active site 688270003101 substrate binding site [chemical binding]; other site 688270003102 cosubstrate binding site; other site 688270003103 catalytic site [active] 688270003104 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 688270003105 RNA/DNA hybrid binding site [nucleotide binding]; other site 688270003106 active site 688270003107 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 688270003108 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 688270003109 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 688270003110 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 688270003111 substrate binding site [chemical binding]; other site 688270003112 ATP binding site [chemical binding]; other site 688270003113 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 688270003114 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 688270003115 active site 688270003116 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 688270003117 active site 688270003118 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 688270003119 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 688270003120 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 688270003121 Part of AAA domain; Region: AAA_19; pfam13245 688270003122 putative recombination protein RecB; Provisional; Region: PRK13909 688270003123 Family description; Region: UvrD_C_2; pfam13538 688270003124 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 688270003125 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 688270003126 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 688270003127 substrate-cofactor binding pocket; other site 688270003128 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270003129 catalytic residue [active] 688270003130 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 688270003131 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 688270003132 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 688270003133 ligand binding site [chemical binding]; other site 688270003134 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 688270003135 short chain dehydrogenase; Provisional; Region: PRK07326 688270003136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270003137 NAD(P) binding site [chemical binding]; other site 688270003138 active site 688270003139 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 688270003140 putative active site [active] 688270003141 catalytic site [active] 688270003142 putative metal binding site [ion binding]; other site 688270003143 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 688270003144 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270003145 DNA binding residues [nucleotide binding] 688270003146 FecR protein; Region: FecR; pfam04773 688270003147 Secretin and TonB N terminus short domain; Region: STN; pfam07660 688270003148 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270003149 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270003150 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 688270003151 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270003152 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 688270003153 starch binding outer membrane protein SusD; Region: SusD; cl17845 688270003154 SusD family; Region: SusD; pfam07980 688270003155 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 688270003156 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 688270003157 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 688270003158 ligand binding site [chemical binding]; other site 688270003159 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 688270003160 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 688270003161 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 688270003162 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 688270003163 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 688270003164 Ligand Binding Site [chemical binding]; other site 688270003165 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 688270003166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 688270003167 Coenzyme A binding pocket [chemical binding]; other site 688270003168 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 688270003169 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 688270003170 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 688270003171 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 688270003172 substrate binding site [chemical binding]; other site 688270003173 oxyanion hole (OAH) forming residues; other site 688270003174 trimer interface [polypeptide binding]; other site 688270003175 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 688270003176 active site 688270003177 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 688270003178 putative active site [active] 688270003179 putative metal binding site [ion binding]; other site 688270003180 enterobactin exporter EntS; Provisional; Region: PRK10489 688270003181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 688270003182 putative substrate translocation pore; other site 688270003183 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 688270003184 DHH family; Region: DHH; pfam01368 688270003185 DHHA1 domain; Region: DHHA1; pfam02272 688270003186 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 688270003187 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 688270003188 four helix bundle protein; Region: TIGR02436 688270003189 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 688270003190 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 688270003191 HopJ type III effector protein; Region: HopJ; pfam08888 688270003192 Predicted methyltransferases [General function prediction only]; Region: COG0313 688270003193 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 688270003194 putative SAM binding site [chemical binding]; other site 688270003195 putative homodimer interface [polypeptide binding]; other site 688270003196 DoxX-like family; Region: DoxX_2; pfam13564 688270003197 thymidine kinase; Provisional; Region: PRK04296 688270003198 alanine racemase; Reviewed; Region: alr; PRK00053 688270003199 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 688270003200 active site 688270003201 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 688270003202 dimer interface [polypeptide binding]; other site 688270003203 substrate binding site [chemical binding]; other site 688270003204 catalytic residues [active] 688270003205 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 688270003206 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 688270003207 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 688270003208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270003209 active site 688270003210 phosphorylation site [posttranslational modification] 688270003211 intermolecular recognition site; other site 688270003212 dimerization interface [polypeptide binding]; other site 688270003213 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 688270003214 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 688270003215 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 688270003216 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 688270003217 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 688270003218 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 688270003219 Walker A/P-loop; other site 688270003220 ATP binding site [chemical binding]; other site 688270003221 Q-loop/lid; other site 688270003222 ABC transporter signature motif; other site 688270003223 Walker B; other site 688270003224 D-loop; other site 688270003225 H-loop/switch region; other site 688270003226 hypothetical protein; Provisional; Region: PRK09256 688270003227 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 688270003228 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 688270003229 Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782 688270003230 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 688270003231 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 688270003232 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 688270003233 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 688270003234 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 688270003235 Uncharacterized conserved protein [Function unknown]; Region: COG1262 688270003236 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 688270003237 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 688270003238 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 688270003239 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 688270003240 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 688270003241 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 688270003242 carboxyltransferase (CT) interaction site; other site 688270003243 biotinylation site [posttranslational modification]; other site 688270003244 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 688270003245 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 688270003246 dimer interface [polypeptide binding]; other site 688270003247 active site 688270003248 CoA binding pocket [chemical binding]; other site 688270003249 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 688270003250 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 688270003251 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 688270003252 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 688270003253 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 688270003254 Lumazine binding domain; Region: Lum_binding; pfam00677 688270003255 Lumazine binding domain; Region: Lum_binding; pfam00677 688270003256 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 688270003257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 688270003258 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 688270003259 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270003260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270003261 ATP binding site [chemical binding]; other site 688270003262 Mg2+ binding site [ion binding]; other site 688270003263 G-X-G motif; other site 688270003264 Response regulator receiver domain; Region: Response_reg; pfam00072 688270003265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270003266 active site 688270003267 phosphorylation site [posttranslational modification] 688270003268 intermolecular recognition site; other site 688270003269 dimerization interface [polypeptide binding]; other site 688270003270 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 688270003271 Rab subfamily motif 1 (RabSF1); other site 688270003272 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 688270003273 G1 box; other site 688270003274 GTP/Mg2+ binding site [chemical binding]; other site 688270003275 Rab subfamily motif 2 (RabSF2); other site 688270003276 Switch I region; other site 688270003277 G2 box; other site 688270003278 effector interaction site; other site 688270003279 GDI interaction site; other site 688270003280 Rab family motif 1 (RabF1); other site 688270003281 GEF interaction site [polypeptide binding]; other site 688270003282 Rab family motif 2 (RabF2); other site 688270003283 G3 box; other site 688270003284 Switch II region; other site 688270003285 Rab family motif 3 (RabF3); other site 688270003286 Rab family motif 4 (RabF4); other site 688270003287 Rab family motif 5 (RabF5); other site 688270003288 Rab subfamily motif 3 (RabSF3); other site 688270003289 G4 box; other site 688270003290 G5 box; other site 688270003291 Rab subfamily motif 4 (RabSF4); other site 688270003292 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 688270003293 Rubredoxin; Region: Rubredoxin; pfam00301 688270003294 iron binding site [ion binding]; other site 688270003295 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 688270003296 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 688270003297 [4Fe-4S] binding site [ion binding]; other site 688270003298 molybdopterin cofactor binding site; other site 688270003299 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 688270003300 molybdopterin cofactor binding site; other site 688270003301 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 688270003302 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 688270003303 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 688270003304 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 688270003305 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 688270003306 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 688270003307 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 688270003308 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 688270003309 classical (c) SDRs; Region: SDR_c; cd05233 688270003310 NAD(P) binding site [chemical binding]; other site 688270003311 active site 688270003312 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 688270003313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270003314 active site 688270003315 phosphorylation site [posttranslational modification] 688270003316 intermolecular recognition site; other site 688270003317 dimerization interface [polypeptide binding]; other site 688270003318 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 688270003319 DNA binding residues [nucleotide binding] 688270003320 dimerization interface [polypeptide binding]; other site 688270003321 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 688270003322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 688270003323 putative substrate translocation pore; other site 688270003324 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 688270003325 active site 688270003326 SAM binding site [chemical binding]; other site 688270003327 homodimer interface [polypeptide binding]; other site 688270003328 nitrite reductase subunit NirD; Provisional; Region: PRK14989 688270003329 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 688270003330 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 688270003331 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 688270003332 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 688270003333 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 688270003334 Domain of unknown function (DUF4202); Region: DUF4202; pfam13875 688270003335 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 688270003336 PAS domain; Region: PAS_9; pfam13426 688270003337 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270003338 putative active site [active] 688270003339 heme pocket [chemical binding]; other site 688270003340 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 688270003341 Histidine kinase; Region: HisKA_3; pfam07730 688270003342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270003343 ATP binding site [chemical binding]; other site 688270003344 Mg2+ binding site [ion binding]; other site 688270003345 G-X-G motif; other site 688270003346 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270003347 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270003348 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 688270003349 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 688270003350 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 688270003351 active site 688270003352 nucleophile elbow; other site 688270003353 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 688270003354 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 688270003355 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 688270003356 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 688270003357 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08332 688270003358 alpha-glucosidase; Provisional; Region: PRK10137 688270003359 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 688270003360 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 688270003361 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 688270003362 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 688270003363 substrate binding site [chemical binding]; other site 688270003364 activation loop (A-loop); other site 688270003365 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 688270003366 metal ion-dependent adhesion site (MIDAS); other site 688270003367 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 688270003368 metal ion-dependent adhesion site (MIDAS); other site 688270003369 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 688270003370 metal ion-dependent adhesion site (MIDAS); other site 688270003371 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 688270003372 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 688270003373 putative metal binding site [ion binding]; other site 688270003374 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 688270003375 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 688270003376 putative metal binding site [ion binding]; other site 688270003377 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 688270003378 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 688270003379 putative metal binding site [ion binding]; other site 688270003380 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 688270003381 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 688270003382 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 688270003383 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 688270003384 putative metal binding site [ion binding]; other site 688270003385 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 688270003386 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 688270003387 transmembrane helices; other site 688270003388 TIGR04255 family protein; Region: sporadTIGR04255 688270003389 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 688270003390 DNA binding residues [nucleotide binding] 688270003391 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 688270003392 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 688270003393 dimer interface [polypeptide binding]; other site 688270003394 substrate binding site [chemical binding]; other site 688270003395 metal binding site [ion binding]; metal-binding site 688270003396 Ribosome-binding factor A; Region: RBFA; pfam02033 688270003397 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 688270003398 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 688270003399 FtsX-like permease family; Region: FtsX; pfam02687 688270003400 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 688270003401 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 688270003402 FMN binding site [chemical binding]; other site 688270003403 active site 688270003404 catalytic residues [active] 688270003405 substrate binding site [chemical binding]; other site 688270003406 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 688270003407 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270003408 GTP-binding protein LepA; Provisional; Region: PRK05433 688270003409 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 688270003410 G1 box; other site 688270003411 putative GEF interaction site [polypeptide binding]; other site 688270003412 GTP/Mg2+ binding site [chemical binding]; other site 688270003413 Switch I region; other site 688270003414 G2 box; other site 688270003415 G3 box; other site 688270003416 Switch II region; other site 688270003417 G4 box; other site 688270003418 G5 box; other site 688270003419 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 688270003420 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 688270003421 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 688270003422 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 688270003423 TrkA-N domain; Region: TrkA_N; pfam02254 688270003424 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 688270003425 Ligand Binding Site [chemical binding]; other site 688270003426 Universal stress protein family; Region: Usp; pfam00582 688270003427 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 688270003428 Sulfate transporter family; Region: Sulfate_transp; pfam00916 688270003429 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 688270003430 CHASE domain; Region: CHASE; pfam03924 688270003431 PAS domain S-box; Region: sensory_box; TIGR00229 688270003432 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270003433 putative active site [active] 688270003434 heme pocket [chemical binding]; other site 688270003435 PAS domain S-box; Region: sensory_box; TIGR00229 688270003436 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270003437 putative active site [active] 688270003438 heme pocket [chemical binding]; other site 688270003439 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270003440 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 688270003441 putative active site [active] 688270003442 heme pocket [chemical binding]; other site 688270003443 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270003444 putative active site [active] 688270003445 heme pocket [chemical binding]; other site 688270003446 PAS domain S-box; Region: sensory_box; TIGR00229 688270003447 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270003448 putative active site [active] 688270003449 heme pocket [chemical binding]; other site 688270003450 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270003451 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270003452 dimer interface [polypeptide binding]; other site 688270003453 phosphorylation site [posttranslational modification] 688270003454 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270003455 ATP binding site [chemical binding]; other site 688270003456 Mg2+ binding site [ion binding]; other site 688270003457 G-X-G motif; other site 688270003458 Response regulator receiver domain; Region: Response_reg; pfam00072 688270003459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270003460 active site 688270003461 phosphorylation site [posttranslational modification] 688270003462 intermolecular recognition site; other site 688270003463 dimerization interface [polypeptide binding]; other site 688270003464 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 688270003465 dimerization interface [polypeptide binding]; other site 688270003466 putative DNA binding site [nucleotide binding]; other site 688270003467 putative Zn2+ binding site [ion binding]; other site 688270003468 Low molecular weight phosphatase family; Region: LMWPc; cl00105 688270003469 active site 688270003470 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 688270003471 arsenical-resistance protein; Region: acr3; TIGR00832 688270003472 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 688270003473 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 688270003474 Peptidase S8 family domain in Subtilisin_Novo-like proteins; Region: Peptidases_S8_Subtilisin_Novo-like; cd07483 688270003475 active site 688270003476 catalytic triad [active] 688270003477 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 688270003478 Zn binding site [ion binding]; other site 688270003479 ribonuclease P; Reviewed; Region: rnpA; PRK01903 688270003480 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 688270003481 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 688270003482 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 688270003483 protein binding site [polypeptide binding]; other site 688270003484 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 688270003485 Catalytic dyad [active] 688270003486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 688270003487 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 688270003488 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 688270003489 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 688270003490 Family of unknown function (DUF695); Region: DUF695; pfam05117 688270003491 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 688270003492 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270003493 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 688270003494 NAD(P) binding site [chemical binding]; other site 688270003495 active site 688270003496 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 688270003497 Domain of unknown function (DUF1287); Region: DUF1287; pfam06940 688270003498 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 688270003499 putative ligand binding site [chemical binding]; other site 688270003500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 688270003501 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 688270003502 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 688270003503 YARHG domain; Region: YARHG; pfam13308 688270003504 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 688270003505 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 688270003506 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 688270003507 Plasmodium Vir superfamily; Provisional; Region: PTZ00473 688270003508 Bacterial SH3 domain; Region: SH3_3; cl17532 688270003509 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 688270003510 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 688270003511 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 688270003512 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 688270003513 NlpC/P60 family; Region: NLPC_P60; pfam00877 688270003514 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 688270003515 Coenzyme A binding pocket [chemical binding]; other site 688270003516 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 688270003517 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 688270003518 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 688270003519 ribonuclease R; Region: RNase_R; TIGR02063 688270003520 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 688270003521 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 688270003522 RNB domain; Region: RNB; pfam00773 688270003523 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 688270003524 RNA binding site [nucleotide binding]; other site 688270003525 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 688270003526 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 688270003527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 688270003528 Dihydroneopterin aldolase; Region: FolB; pfam02152 688270003529 active site 688270003530 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 688270003531 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 688270003532 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 688270003533 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 688270003534 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 688270003535 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 688270003536 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 688270003537 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 688270003538 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 688270003539 active site 688270003540 HIGH motif; other site 688270003541 nucleotide binding site [chemical binding]; other site 688270003542 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 688270003543 active site 688270003544 KMSKS motif; other site 688270003545 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 688270003546 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 688270003547 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 688270003548 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 688270003549 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 688270003550 HIGH motif; other site 688270003551 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 688270003552 active site 688270003553 KMSKS motif; other site 688270003554 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 688270003555 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 688270003556 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 688270003557 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 688270003558 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 688270003559 Methyltransferase domain; Region: Methyltransf_23; pfam13489 688270003560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 688270003561 S-adenosylmethionine binding site [chemical binding]; other site 688270003562 Predicted membrane protein [Function unknown]; Region: COG4682 688270003563 yiaA/B two helix domain; Region: YiaAB; pfam05360 688270003564 yiaA/B two helix domain; Region: YiaAB; pfam05360 688270003565 Transposase IS200 like; Region: Y1_Tnp; cl00848 688270003566 PQQ-like domain; Region: PQQ_2; pfam13360 688270003567 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 688270003568 Coenzyme A binding pocket [chemical binding]; other site 688270003569 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 688270003570 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 688270003571 DNA polymerase III subunit delta'; Validated; Region: PRK08485 688270003572 Phosphoglycerate kinase; Region: PGK; pfam00162 688270003573 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 688270003574 substrate binding site [chemical binding]; other site 688270003575 hinge regions; other site 688270003576 ADP binding site [chemical binding]; other site 688270003577 catalytic site [active] 688270003578 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 688270003579 N-acetyl-D-glucosamine binding site [chemical binding]; other site 688270003580 catalytic residue [active] 688270003581 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 688270003582 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 688270003583 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 688270003584 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 688270003585 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 688270003586 Transglycosylase; Region: Transgly; pfam00912 688270003587 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 688270003588 GldH lipoprotein; Region: GldH_lipo; pfam14109 688270003589 PSP1 C-terminal conserved region; Region: PSP1; cl00770 688270003590 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 688270003591 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 688270003592 active site residue [active] 688270003593 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 688270003594 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 688270003595 hexamer interface [polypeptide binding]; other site 688270003596 Walker A motif; other site 688270003597 ATP binding site [chemical binding]; other site 688270003598 Walker B motif; other site 688270003599 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 688270003600 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 688270003601 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270003602 DNA binding residues [nucleotide binding] 688270003603 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 688270003604 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 688270003605 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 688270003606 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 688270003607 putative acyl-acceptor binding pocket; other site 688270003608 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 688270003609 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 688270003610 active site 688270003611 HIGH motif; other site 688270003612 dimer interface [polypeptide binding]; other site 688270003613 KMSKS motif; other site 688270003614 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 688270003615 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 688270003616 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 688270003617 DNA protecting protein DprA; Region: dprA; TIGR00732 688270003618 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 688270003619 Sporulation related domain; Region: SPOR; pfam05036 688270003620 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 688270003621 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 688270003622 Peptidase family M23; Region: Peptidase_M23; pfam01551 688270003623 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 688270003624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270003625 binding surface 688270003626 TPR motif; other site 688270003627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 688270003628 binding surface 688270003629 TPR motif; other site 688270003630 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 688270003631 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 688270003632 active site 688270003633 Substrate binding site; other site 688270003634 Mg++ binding site; other site 688270003635 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 688270003636 putative trimer interface [polypeptide binding]; other site 688270003637 putative CoA binding site [chemical binding]; other site 688270003638 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 688270003639 trimer interface [polypeptide binding]; other site 688270003640 active site 688270003641 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 688270003642 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 688270003643 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 688270003644 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 688270003645 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270003646 DNA binding residues [nucleotide binding] 688270003647 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 688270003648 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 688270003649 core domain interface [polypeptide binding]; other site 688270003650 delta subunit interface [polypeptide binding]; other site 688270003651 epsilon subunit interface [polypeptide binding]; other site 688270003652 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 688270003653 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 688270003654 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 688270003655 beta subunit interaction interface [polypeptide binding]; other site 688270003656 Walker A motif; other site 688270003657 ATP binding site [chemical binding]; other site 688270003658 Walker B motif; other site 688270003659 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 688270003660 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 688270003661 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 688270003662 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 688270003663 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 688270003664 ATP synthase subunit C; Region: ATP-synt_C; cl00466 688270003665 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 688270003666 ATP synthase A chain; Region: ATP-synt_A; cl00413 688270003667 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 688270003668 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 688270003669 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 688270003670 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 688270003671 Walker A/P-loop; other site 688270003672 ATP binding site [chemical binding]; other site 688270003673 Q-loop/lid; other site 688270003674 ABC transporter signature motif; other site 688270003675 Walker B; other site 688270003676 D-loop; other site 688270003677 H-loop/switch region; other site 688270003678 Predicted transcriptional regulators [Transcription]; Region: COG1695 688270003679 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 688270003680 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 688270003681 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 688270003682 FAD binding pocket [chemical binding]; other site 688270003683 FAD binding motif [chemical binding]; other site 688270003684 phosphate binding motif [ion binding]; other site 688270003685 beta-alpha-beta structure motif; other site 688270003686 NAD(p) ribose binding residues [chemical binding]; other site 688270003687 NAD binding pocket [chemical binding]; other site 688270003688 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 688270003689 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 688270003690 catalytic loop [active] 688270003691 iron binding site [ion binding]; other site 688270003692 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 688270003693 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 688270003694 active site 688270003695 nucleophile elbow; other site 688270003696 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 688270003697 Phosphotransferase enzyme family; Region: APH; pfam01636 688270003698 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 688270003699 active site 688270003700 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 688270003701 starch binding outer membrane protein SusD; Region: SusD; cl17845 688270003702 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270003703 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270003704 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 688270003705 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270003706 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 688270003707 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 688270003708 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 688270003709 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 688270003710 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 688270003711 putative active site [active] 688270003712 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 688270003713 putative MFS family transporter protein; Provisional; Region: PRK03633 688270003714 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 688270003715 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 688270003716 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 688270003717 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 688270003718 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 688270003719 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270003720 NAD(P) binding site [chemical binding]; other site 688270003721 active site 688270003722 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 688270003723 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 688270003724 Mg++ binding site [ion binding]; other site 688270003725 putative catalytic motif [active] 688270003726 substrate binding site [chemical binding]; other site 688270003727 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 688270003728 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 688270003729 O-Antigen ligase; Region: Wzy_C; pfam04932 688270003730 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 688270003731 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 688270003732 putative trimer interface [polypeptide binding]; other site 688270003733 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 688270003734 trimer interface [polypeptide binding]; other site 688270003735 active site 688270003736 substrate binding site [chemical binding]; other site 688270003737 putative CoA binding site [chemical binding]; other site 688270003738 CoA binding site [chemical binding]; other site 688270003739 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 688270003740 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 688270003741 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 688270003742 trimer interface [polypeptide binding]; other site 688270003743 active site 688270003744 substrate binding site [chemical binding]; other site 688270003745 CoA binding site [chemical binding]; other site 688270003746 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 688270003747 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 688270003748 active site 688270003749 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 688270003750 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 688270003751 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 688270003752 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 688270003753 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 688270003754 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 688270003755 NADP binding site [chemical binding]; other site 688270003756 active site 688270003757 putative substrate binding site [chemical binding]; other site 688270003758 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 688270003759 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 688270003760 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 688270003761 substrate binding site; other site 688270003762 tetramer interface; other site 688270003763 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 688270003764 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 688270003765 NAD binding site [chemical binding]; other site 688270003766 substrate binding site [chemical binding]; other site 688270003767 homodimer interface [polypeptide binding]; other site 688270003768 active site 688270003769 GH3 auxin-responsive promoter; Region: GH3; pfam03321 688270003770 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 688270003771 Peptidase family M23; Region: Peptidase_M23; pfam01551 688270003772 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 688270003773 HYR domain; Region: HYR; pfam02494 688270003774 Domain of unknown function DUF11; Region: DUF11; pfam01345 688270003775 Domain of unknown function DUF11; Region: DUF11; pfam01345 688270003776 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 688270003777 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 688270003778 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 688270003779 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 688270003780 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 688270003781 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 688270003782 ligand binding site [chemical binding]; other site 688270003783 Transposase domain (DUF772); Region: DUF772; pfam05598 688270003784 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 688270003785 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 688270003786 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 688270003787 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 688270003788 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 688270003789 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 688270003790 L-aspartate oxidase; Provisional; Region: PRK06175 688270003791 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 688270003792 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 688270003793 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 688270003794 distal heme binding site [chemical binding]; other site 688270003795 proximal heme binding site [chemical binding]; other site 688270003796 putative dimer interface [polypeptide binding]; other site 688270003797 putative Iron-sulfur protein interface [polypeptide binding]; other site 688270003798 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 688270003799 Cupin domain; Region: Cupin_2; pfam07883 688270003800 Ycf48-like protein; Provisional; Region: PRK13684 688270003801 VPS10 domain; Region: VPS10; smart00602 688270003802 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 688270003803 proline aminopeptidase P II; Provisional; Region: PRK10879 688270003804 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 688270003805 active site 688270003806 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 688270003807 active site 688270003808 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 688270003809 Fasciclin domain; Region: Fasciclin; pfam02469 688270003810 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 688270003811 Predicted membrane protein [Function unknown]; Region: COG1288 688270003812 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 688270003813 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 688270003814 active site 688270003815 dinuclear metal binding site [ion binding]; other site 688270003816 dimerization interface [polypeptide binding]; other site 688270003817 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 688270003818 thiamine monophosphate kinase; Provisional; Region: PRK05731 688270003819 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 688270003820 ATP binding site [chemical binding]; other site 688270003821 dimerization interface [polypeptide binding]; other site 688270003822 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 688270003823 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 688270003824 putative ABC transporter; Region: ycf24; CHL00085 688270003825 FeS assembly ATPase SufC; Region: sufC; TIGR01978 688270003826 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 688270003827 Walker A/P-loop; other site 688270003828 ATP binding site [chemical binding]; other site 688270003829 Q-loop/lid; other site 688270003830 ABC transporter signature motif; other site 688270003831 Walker B; other site 688270003832 D-loop; other site 688270003833 H-loop/switch region; other site 688270003834 FeS assembly protein SufD; Region: sufD; TIGR01981 688270003835 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 688270003836 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 688270003837 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 688270003838 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 688270003839 catalytic residue [active] 688270003840 Fe-S metabolism associated domain; Region: SufE; cl00951 688270003841 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 688270003842 Protein of unknown function (DUF2480); Region: DUF2480; pfam10652 688270003843 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 688270003844 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 688270003845 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 688270003846 HflX GTPase family; Region: HflX; cd01878 688270003847 G1 box; other site 688270003848 GTP/Mg2+ binding site [chemical binding]; other site 688270003849 Switch I region; other site 688270003850 G2 box; other site 688270003851 G3 box; other site 688270003852 Switch II region; other site 688270003853 G4 box; other site 688270003854 G5 box; other site 688270003855 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 688270003856 putative catalytic site [active] 688270003857 putative metal binding site [ion binding]; other site 688270003858 putative phosphate binding site [ion binding]; other site 688270003859 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 688270003860 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 688270003861 active site 688270003862 catalytic triad [active] 688270003863 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 688270003864 Interdomain contacts; other site 688270003865 Cytokine receptor motif; other site 688270003866 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 688270003867 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 688270003868 active site 688270003869 catalytic site [active] 688270003870 substrate binding site [chemical binding]; other site 688270003871 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 688270003872 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 688270003873 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 688270003874 DNA binding site [nucleotide binding] 688270003875 active site 688270003876 Domain of unknown function DUF21; Region: DUF21; pfam01595 688270003877 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 688270003878 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 688270003879 dimer interface [polypeptide binding]; other site 688270003880 allosteric magnesium binding site [ion binding]; other site 688270003881 active site 688270003882 aspartate-rich active site metal binding site; other site 688270003883 Schiff base residues; other site 688270003884 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 688270003885 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 688270003886 Walker A/P-loop; other site 688270003887 ATP binding site [chemical binding]; other site 688270003888 Q-loop/lid; other site 688270003889 ABC transporter signature motif; other site 688270003890 Walker B; other site 688270003891 D-loop; other site 688270003892 H-loop/switch region; other site 688270003893 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 688270003894 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 688270003895 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 688270003896 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 688270003897 Zn binding site [ion binding]; other site 688270003898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 688270003899 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 688270003900 EamA-like transporter family; Region: EamA; pfam00892 688270003901 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270003902 TPR motif; other site 688270003903 binding surface 688270003904 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 688270003905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270003906 TPR motif; other site 688270003907 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270003908 binding surface 688270003909 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 688270003910 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270003911 binding surface 688270003912 Tetratricopeptide repeat; Region: TPR_16; pfam13432 688270003913 TPR motif; other site 688270003914 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 688270003915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 688270003916 ATP binding site [chemical binding]; other site 688270003917 Walker A motif; other site 688270003918 Walker B motif; other site 688270003919 Protein of unknown function (DUF740); Region: DUF740; pfam05340 688270003920 arginine finger; other site 688270003921 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 688270003922 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 688270003923 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 688270003924 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 688270003925 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 688270003926 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 688270003927 substrate binding site [chemical binding]; other site 688270003928 active site 688270003929 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 688270003930 TrkA-N domain; Region: TrkA_N; pfam02254 688270003931 TrkA-C domain; Region: TrkA_C; pfam02080 688270003932 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 688270003933 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 688270003934 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 688270003935 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 688270003936 domain interfaces; other site 688270003937 active site 688270003938 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 688270003939 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 688270003940 active site 688270003941 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 688270003942 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 688270003943 tRNA; other site 688270003944 putative tRNA binding site [nucleotide binding]; other site 688270003945 putative NADP binding site [chemical binding]; other site 688270003946 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 688270003947 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 688270003948 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 688270003949 Trehalose utilisation; Region: ThuA; pfam06283 688270003950 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 688270003951 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 688270003952 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 688270003953 Walker A/P-loop; other site 688270003954 ATP binding site [chemical binding]; other site 688270003955 Q-loop/lid; other site 688270003956 ABC transporter signature motif; other site 688270003957 Walker B; other site 688270003958 D-loop; other site 688270003959 H-loop/switch region; other site 688270003960 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 688270003961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 688270003962 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 688270003963 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 688270003964 ligand binding site [chemical binding]; other site 688270003965 IncA protein; Region: IncA; pfam04156 688270003966 pectinesterase; Region: PLN02197 688270003967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 688270003968 AAA domain; Region: AAA_22; pfam13401 688270003969 Walker A motif; other site 688270003970 ATP binding site [chemical binding]; other site 688270003971 Walker B motif; other site 688270003972 arginine finger; other site 688270003973 TraB family; Region: TraB; pfam01963 688270003974 Mechanosensitive ion channel; Region: MS_channel; pfam00924 688270003975 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 688270003976 ferrochelatase; Reviewed; Region: hemH; PRK00035 688270003977 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 688270003978 C-terminal domain interface [polypeptide binding]; other site 688270003979 active site 688270003980 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 688270003981 active site 688270003982 N-terminal domain interface [polypeptide binding]; other site 688270003983 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 688270003984 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 688270003985 EcsC protein family; Region: EcsC; pfam12787 688270003986 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 688270003987 Asp-box motif; other site 688270003988 BNR repeat-like domain; Region: BNR_2; pfam13088 688270003989 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 688270003990 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 688270003991 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270003992 dimer interface [polypeptide binding]; other site 688270003993 phosphorylation site [posttranslational modification] 688270003994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270003995 ATP binding site [chemical binding]; other site 688270003996 Mg2+ binding site [ion binding]; other site 688270003997 G-X-G motif; other site 688270003998 PAAR motif; Region: PAAR_motif; cl15808 688270003999 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 688270004000 CHAP domain; Region: CHAP; cl17642 688270004001 Transposase IS200 like; Region: Y1_Tnp; pfam01797 688270004002 Bacterial SH3 domain; Region: SH3_3; pfam08239 688270004003 TIGR02594 family protein; Region: TIGR02594 688270004004 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 688270004005 Integrase core domain; Region: rve; pfam00665 688270004006 Integrase core domain; Region: rve_3; pfam13683 688270004007 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 688270004008 DNA-binding interface [nucleotide binding]; DNA binding site 688270004009 Receptor L domain; Region: Recep_L_domain; pfam01030 688270004010 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 688270004011 DNA-binding interface [nucleotide binding]; DNA binding site 688270004012 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 688270004013 Integrase core domain; Region: rve; pfam00665 688270004014 Integrase core domain; Region: rve_3; pfam13683 688270004015 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 688270004016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 688270004017 Coenzyme A binding pocket [chemical binding]; other site 688270004018 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 688270004019 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 688270004020 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 688270004021 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 688270004022 putative catalytic cysteine [active] 688270004023 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 688270004024 nucleotide binding site [chemical binding]; other site 688270004025 homotetrameric interface [polypeptide binding]; other site 688270004026 putative phosphate binding site [ion binding]; other site 688270004027 putative allosteric binding site; other site 688270004028 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 688270004029 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 688270004030 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 688270004031 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 688270004032 substrate binding site [chemical binding]; other site 688270004033 oxyanion hole (OAH) forming residues; other site 688270004034 trimer interface [polypeptide binding]; other site 688270004035 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 688270004036 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 688270004037 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 688270004038 catalytic residues [active] 688270004039 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 688270004040 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 688270004041 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 688270004042 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 688270004043 Zn2+ binding site [ion binding]; other site 688270004044 Mg2+ binding site [ion binding]; other site 688270004045 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 688270004046 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 688270004047 putative acyl-acceptor binding pocket; other site 688270004048 Disulphide isomerase; Region: Disulph_isomer; pfam06491 688270004049 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 688270004050 putative metal binding site [ion binding]; other site 688270004051 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 688270004052 HSP70 interaction site [polypeptide binding]; other site 688270004053 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 688270004054 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 688270004055 catalytic motif [active] 688270004056 Zn binding site [ion binding]; other site 688270004057 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 688270004058 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 688270004059 protein binding site [polypeptide binding]; other site 688270004060 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 688270004061 Catalytic dyad [active] 688270004062 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 688270004063 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 688270004064 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270004065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270004066 binding surface 688270004067 TPR motif; other site 688270004068 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270004069 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270004070 binding surface 688270004071 TPR motif; other site 688270004072 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270004073 Histidine kinase; Region: His_kinase; pfam06580 688270004074 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 688270004075 ATP binding site [chemical binding]; other site 688270004076 Mg2+ binding site [ion binding]; other site 688270004077 G-X-G motif; other site 688270004078 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 688270004079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270004080 active site 688270004081 phosphorylation site [posttranslational modification] 688270004082 intermolecular recognition site; other site 688270004083 dimerization interface [polypeptide binding]; other site 688270004084 LytTr DNA-binding domain; Region: LytTR; smart00850 688270004085 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 688270004086 dimer interface [polypeptide binding]; other site 688270004087 putative radical transfer pathway; other site 688270004088 diiron center [ion binding]; other site 688270004089 tyrosyl radical; other site 688270004090 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 688270004091 ATP cone domain; Region: ATP-cone; pfam03477 688270004092 Class I ribonucleotide reductase; Region: RNR_I; cd01679 688270004093 active site 688270004094 dimer interface [polypeptide binding]; other site 688270004095 catalytic residues [active] 688270004096 effector binding site; other site 688270004097 R2 peptide binding site; other site 688270004098 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 688270004099 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 688270004100 Predicted oxidoreductase [General function prediction only]; Region: COG3573 688270004101 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 688270004102 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 688270004103 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 688270004104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 688270004105 Major Facilitator Superfamily; Region: MFS_1; pfam07690 688270004106 putative substrate translocation pore; other site 688270004107 nucleoside transporter; Region: 2A0110; TIGR00889 688270004108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 688270004109 putative substrate translocation pore; other site 688270004110 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 688270004111 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 688270004112 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 688270004113 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 688270004114 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 688270004115 Predicted oxidoreductase [General function prediction only]; Region: COG3573 688270004116 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 688270004117 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 688270004118 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 688270004119 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 688270004120 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 688270004121 hypothetical protein; Provisional; Region: PRK11820 688270004122 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 688270004123 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 688270004124 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 688270004125 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 688270004126 catalytic site [active] 688270004127 G-X2-G-X-G-K; other site 688270004128 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 688270004129 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 688270004130 active site 688270004131 (T/H)XGH motif; other site 688270004132 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 688270004133 active site 688270004134 Phosphate transporter family; Region: PHO4; pfam01384 688270004135 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270004136 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 688270004137 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 688270004138 Zn2+ binding site [ion binding]; other site 688270004139 Mg2+ binding site [ion binding]; other site 688270004140 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 688270004141 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 688270004142 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 688270004143 TPP-binding site; other site 688270004144 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 688270004145 PYR/PP interface [polypeptide binding]; other site 688270004146 dimer interface [polypeptide binding]; other site 688270004147 TPP binding site [chemical binding]; other site 688270004148 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 688270004149 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 688270004150 nucleoside/Zn binding site; other site 688270004151 dimer interface [polypeptide binding]; other site 688270004152 catalytic motif [active] 688270004153 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 688270004154 DNA-binding site [nucleotide binding]; DNA binding site 688270004155 RNA-binding motif; other site 688270004156 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 688270004157 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 688270004158 Cl- selectivity filter; other site 688270004159 Cl- binding residues [ion binding]; other site 688270004160 pore gating glutamate residue; other site 688270004161 dimer interface [polypeptide binding]; other site 688270004162 FOG: CBS domain [General function prediction only]; Region: COG0517 688270004163 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 688270004164 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 688270004165 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 688270004166 dimer interface [polypeptide binding]; other site 688270004167 anticodon binding site; other site 688270004168 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 688270004169 homodimer interface [polypeptide binding]; other site 688270004170 motif 1; other site 688270004171 active site 688270004172 motif 2; other site 688270004173 GAD domain; Region: GAD; pfam02938 688270004174 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 688270004175 active site 688270004176 motif 3; other site 688270004177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 688270004178 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 688270004179 Protein export membrane protein; Region: SecD_SecF; cl14618 688270004180 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 688270004181 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 688270004182 E3 interaction surface; other site 688270004183 lipoyl attachment site [posttranslational modification]; other site 688270004184 HlyD family secretion protein; Region: HlyD_3; pfam13437 688270004185 Outer membrane efflux protein; Region: OEP; pfam02321 688270004186 Outer membrane efflux protein; Region: OEP; pfam02321 688270004187 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 688270004188 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 688270004189 Poxvirus E8 protein; Region: Pox_E8; cl17578 688270004190 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 688270004191 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 688270004192 substrate binding pocket [chemical binding]; other site 688270004193 chain length determination region; other site 688270004194 substrate-Mg2+ binding site; other site 688270004195 catalytic residues [active] 688270004196 aspartate-rich region 1; other site 688270004197 active site lid residues [active] 688270004198 aspartate-rich region 2; other site 688270004199 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 688270004200 lycopene cyclase; Region: lycopene_cycl; TIGR01789 688270004201 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270004202 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 688270004203 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270004204 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 688270004205 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 688270004206 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 688270004207 FeoA domain; Region: FeoA; pfam04023 688270004208 manganese transport protein MntH; Reviewed; Region: PRK00701 688270004209 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 688270004210 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 688270004211 Ligand Binding Site [chemical binding]; other site 688270004212 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 688270004213 PQQ-like domain; Region: PQQ_2; pfam13360 688270004214 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 688270004215 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 688270004216 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 688270004217 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 688270004218 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 688270004219 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 688270004220 protein binding site [polypeptide binding]; other site 688270004221 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 688270004222 Domain interface; other site 688270004223 Peptide binding site; other site 688270004224 Active site tetrad [active] 688270004225 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 688270004226 putative ligand binding site [chemical binding]; other site 688270004227 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270004228 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 688270004229 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 688270004230 G1 box; other site 688270004231 GTP/Mg2+ binding site [chemical binding]; other site 688270004232 Switch I region; other site 688270004233 G2 box; other site 688270004234 G3 box; other site 688270004235 Switch II region; other site 688270004236 G4 box; other site 688270004237 G5 box; other site 688270004238 Nucleoside recognition; Region: Gate; pfam07670 688270004239 Nucleoside recognition; Region: Gate; pfam07670 688270004240 FeoA domain; Region: FeoA; pfam04023 688270004241 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 688270004242 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 688270004243 Cu(I) binding site [ion binding]; other site 688270004244 RIP metalloprotease RseP; Region: TIGR00054 688270004245 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 688270004246 active site 688270004247 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 688270004248 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 688270004249 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 688270004250 putative substrate binding region [chemical binding]; other site 688270004251 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 688270004252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270004253 active site 688270004254 phosphorylation site [posttranslational modification] 688270004255 intermolecular recognition site; other site 688270004256 dimerization interface [polypeptide binding]; other site 688270004257 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 688270004258 DNA binding site [nucleotide binding] 688270004259 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270004260 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 688270004261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270004262 ATP binding site [chemical binding]; other site 688270004263 Mg2+ binding site [ion binding]; other site 688270004264 G-X-G motif; other site 688270004265 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 688270004266 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270004267 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 688270004268 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 688270004269 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 688270004270 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 688270004271 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 688270004272 Sulfatase; Region: Sulfatase; cl17466 688270004273 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 688270004274 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 688270004275 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 688270004276 active site 688270004277 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 688270004278 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 688270004279 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 688270004280 DNA binding residues [nucleotide binding] 688270004281 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270004282 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270004283 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 688270004284 starch binding outer membrane protein SusD; Region: SusD; cl17845 688270004285 SusD family; Region: SusD; pfam07980 688270004286 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 688270004287 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 688270004288 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 688270004289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 688270004290 Putative glucoamylase; Region: Glycoamylase; pfam10091 688270004291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 688270004292 Putative glucoamylase; Region: Glycoamylase; pfam10091 688270004293 Predicted peptidase [General function prediction only]; Region: COG4099 688270004294 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 688270004295 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 688270004296 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 688270004297 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 688270004298 intracellular protease, PfpI family; Region: PfpI; TIGR01382 688270004299 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 688270004300 proposed catalytic triad [active] 688270004301 conserved cys residue [active] 688270004302 GH3 auxin-responsive promoter; Region: GH3; pfam03321 688270004303 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 688270004304 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 688270004305 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 688270004306 putative active site [active] 688270004307 catalytic site [active] 688270004308 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 688270004309 putative active site [active] 688270004310 catalytic site [active] 688270004311 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 688270004312 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 688270004313 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 688270004314 glucose-1-dehydrogenase; Provisional; Region: PRK08936 688270004315 NAD binding site [chemical binding]; other site 688270004316 homodimer interface [polypeptide binding]; other site 688270004317 active site 688270004318 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 688270004319 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 688270004320 dimerization interface [polypeptide binding]; other site 688270004321 DPS ferroxidase diiron center [ion binding]; other site 688270004322 ion pore; other site 688270004323 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 688270004324 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 688270004325 CHASE3 domain; Region: CHASE3; pfam05227 688270004326 PAS domain; Region: PAS_9; pfam13426 688270004327 PAS domain; Region: PAS_9; pfam13426 688270004328 PAS fold; Region: PAS_3; pfam08447 688270004329 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270004330 putative active site [active] 688270004331 heme pocket [chemical binding]; other site 688270004332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270004333 dimer interface [polypeptide binding]; other site 688270004334 phosphorylation site [posttranslational modification] 688270004335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270004336 ATP binding site [chemical binding]; other site 688270004337 Mg2+ binding site [ion binding]; other site 688270004338 G-X-G motif; other site 688270004339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270004340 active site 688270004341 phosphorylation site [posttranslational modification] 688270004342 intermolecular recognition site; other site 688270004343 dimerization interface [polypeptide binding]; other site 688270004344 Helix-turn-helix domain; Region: HTH_18; pfam12833 688270004345 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 688270004346 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 688270004347 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 688270004348 Mechanosensitive ion channel; Region: MS_channel; pfam00924 688270004349 Predicted membrane protein [Function unknown]; Region: COG4325 688270004350 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 688270004351 YtxH-like protein; Region: YtxH; cl02079 688270004352 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 688270004353 putative FMN binding site [chemical binding]; other site 688270004354 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 688270004355 Domain of unknown function DUF20; Region: UPF0118; pfam01594 688270004356 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 688270004357 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 688270004358 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 688270004359 dimer interface [polypeptide binding]; other site 688270004360 active site 688270004361 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 688270004362 catalytic residues [active] 688270004363 substrate binding site [chemical binding]; other site 688270004364 agmatinase; Region: agmatinase; TIGR01230 688270004365 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 688270004366 putative active site [active] 688270004367 Mn binding site [ion binding]; other site 688270004368 deoxyhypusine synthase; Region: dhys; TIGR00321 688270004369 Deoxyhypusine synthase; Region: DS; cl00826 688270004370 Deoxyhypusine synthase; Region: DS; cl00826 688270004371 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 688270004372 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 688270004373 ATP-grasp domain; Region: ATP-grasp_4; cl17255 688270004374 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 688270004375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270004376 NAD(P) binding site [chemical binding]; other site 688270004377 active site 688270004378 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 688270004379 SnoaL-like domain; Region: SnoaL_3; pfam13474 688270004380 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 688270004381 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 688270004382 NADH(P)-binding; Region: NAD_binding_10; pfam13460 688270004383 putative NAD(P) binding site [chemical binding]; other site 688270004384 M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; Region: M28_Fxna_like; cd03875 688270004385 Peptidase family M28; Region: Peptidase_M28; pfam04389 688270004386 metal binding site [ion binding]; metal-binding site 688270004387 FOG: CBS domain [General function prediction only]; Region: COG0517 688270004388 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 688270004389 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 688270004390 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 688270004391 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 688270004392 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 688270004393 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 688270004394 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 688270004395 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 688270004396 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 688270004397 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 688270004398 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 688270004399 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 688270004400 pentamer interface [polypeptide binding]; other site 688270004401 dodecaamer interface [polypeptide binding]; other site 688270004402 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 688270004403 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 688270004404 Peptidase family M28; Region: Peptidase_M28; pfam04389 688270004405 metal binding site [ion binding]; metal-binding site 688270004406 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 688270004407 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 688270004408 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 688270004409 putative active site [active] 688270004410 Zn binding site [ion binding]; other site 688270004411 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 688270004412 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 688270004413 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 688270004414 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 688270004415 RNA binding site [nucleotide binding]; other site 688270004416 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 688270004417 Ferritin-like domain; Region: Ferritin; pfam00210 688270004418 ferroxidase diiron center [ion binding]; other site 688270004419 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 688270004420 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 688270004421 active site 688270004422 HIGH motif; other site 688270004423 KMSKS motif; other site 688270004424 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 688270004425 tRNA binding surface [nucleotide binding]; other site 688270004426 anticodon binding site; other site 688270004427 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 688270004428 dimer interface [polypeptide binding]; other site 688270004429 putative tRNA-binding site [nucleotide binding]; other site 688270004430 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 688270004431 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 688270004432 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 688270004433 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 688270004434 Family description; Region: ACT_7; pfam13840 688270004435 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 688270004436 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 688270004437 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 688270004438 catalytic residues [active] 688270004439 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 688270004440 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 688270004441 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 688270004442 ATP binding site [chemical binding]; other site 688270004443 putative Mg++ binding site [ion binding]; other site 688270004444 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 688270004445 nucleotide binding region [chemical binding]; other site 688270004446 ATP-binding site [chemical binding]; other site 688270004447 TRCF domain; Region: TRCF; pfam03461 688270004448 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 688270004449 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 688270004450 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 688270004451 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 688270004452 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 688270004453 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 688270004454 putative active site [active] 688270004455 putative metal binding site [ion binding]; other site 688270004456 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 688270004457 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 688270004458 ATP binding site [chemical binding]; other site 688270004459 putative Mg++ binding site [ion binding]; other site 688270004460 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 688270004461 nucleotide binding region [chemical binding]; other site 688270004462 ATP-binding site [chemical binding]; other site 688270004463 DEAD/H associated; Region: DEAD_assoc; pfam08494 688270004464 ATP-dependent DNA ligase; Validated; Region: PRK09247 688270004465 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 688270004466 active site 688270004467 DNA binding site [nucleotide binding] 688270004468 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 688270004469 DNA binding site [nucleotide binding] 688270004470 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 688270004471 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 688270004472 tellurium resistance terB-like protein; Region: terB_like; cd07177 688270004473 metal binding site [ion binding]; metal-binding site 688270004474 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 688270004475 AMP binding site [chemical binding]; other site 688270004476 metal binding site [ion binding]; metal-binding site 688270004477 active site 688270004478 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 688270004479 Coenzyme A binding pocket [chemical binding]; other site 688270004480 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 688270004481 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 688270004482 nucleotide binding site [chemical binding]; other site 688270004483 substrate binding site [chemical binding]; other site 688270004484 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 688270004485 putative acyl-acceptor binding pocket; other site 688270004486 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 688270004487 TM2 domain; Region: TM2; cl00984 688270004488 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 688270004489 active site 688270004490 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 688270004491 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 688270004492 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_14; cd12179 688270004493 putative ligand binding site [chemical binding]; other site 688270004494 putative NAD binding site [chemical binding]; other site 688270004495 catalytic site [active] 688270004496 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 688270004497 Predicted amidohydrolase [General function prediction only]; Region: COG0388 688270004498 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 688270004499 putative active site [active] 688270004500 catalytic triad [active] 688270004501 putative dimer interface [polypeptide binding]; other site 688270004502 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 688270004503 MgtE intracellular N domain; Region: MgtE_N; pfam03448 688270004504 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 688270004505 Divalent cation transporter; Region: MgtE; pfam01769 688270004506 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 688270004507 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 688270004508 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 688270004509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270004510 binding surface 688270004511 TPR motif; other site 688270004512 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 688270004513 seryl-tRNA synthetase; Provisional; Region: PRK05431 688270004514 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 688270004515 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 688270004516 dimer interface [polypeptide binding]; other site 688270004517 active site 688270004518 motif 1; other site 688270004519 motif 2; other site 688270004520 motif 3; other site 688270004521 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 688270004522 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 688270004523 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 688270004524 active site 688270004525 Riboflavin kinase; Region: Flavokinase; pfam01687 688270004526 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 688270004527 active site 688270004528 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 688270004529 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 688270004530 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 688270004531 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 688270004532 putative active site [active] 688270004533 catalytic residue [active] 688270004534 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 688270004535 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 688270004536 5S rRNA interface [nucleotide binding]; other site 688270004537 CTC domain interface [polypeptide binding]; other site 688270004538 L16 interface [polypeptide binding]; other site 688270004539 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 688270004540 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 688270004541 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 688270004542 active site 688270004543 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 688270004544 active site 688270004545 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 688270004546 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270004547 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270004548 dimer interface [polypeptide binding]; other site 688270004549 phosphorylation site [posttranslational modification] 688270004550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270004551 ATP binding site [chemical binding]; other site 688270004552 Mg2+ binding site [ion binding]; other site 688270004553 G-X-G motif; other site 688270004554 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270004555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270004556 dimer interface [polypeptide binding]; other site 688270004557 phosphorylation site [posttranslational modification] 688270004558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270004559 ATP binding site [chemical binding]; other site 688270004560 Mg2+ binding site [ion binding]; other site 688270004561 G-X-G motif; other site 688270004562 Trehalase; Region: Trehalase; cl17346 688270004563 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 688270004564 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 688270004565 molybdopterin cofactor binding site; other site 688270004566 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 688270004567 putative molybdopterin cofactor binding site; other site 688270004568 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 688270004569 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 688270004570 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 688270004571 active site 688270004572 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 688270004573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 688270004574 S-adenosylmethionine binding site [chemical binding]; other site 688270004575 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 688270004576 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 688270004577 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 688270004578 N-terminal plug; other site 688270004579 ligand-binding site [chemical binding]; other site 688270004580 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 688270004581 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 688270004582 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 688270004583 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 688270004584 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 688270004585 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 688270004586 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 688270004587 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 688270004588 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 688270004589 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 688270004590 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 688270004591 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 688270004592 Flavodoxin; Region: Flavodoxin_1; pfam00258 688270004593 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 688270004594 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 688270004595 FAD binding pocket [chemical binding]; other site 688270004596 conserved FAD binding motif [chemical binding]; other site 688270004597 phosphate binding motif [ion binding]; other site 688270004598 beta-alpha-beta structure motif; other site 688270004599 NAD binding pocket [chemical binding]; other site 688270004600 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 688270004601 RimM N-terminal domain; Region: RimM; pfam01782 688270004602 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521 688270004603 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 688270004604 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 688270004605 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 688270004606 active site 688270004607 catalytic site [active] 688270004608 substrate binding site [chemical binding]; other site 688270004609 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 688270004610 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 688270004611 active site 688270004612 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 688270004613 generic binding surface I; other site 688270004614 generic binding surface II; other site 688270004615 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 688270004616 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 688270004617 catalytic residues [active] 688270004618 Protein of unknown function DUF58; Region: DUF58; pfam01882 688270004619 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 688270004620 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270004621 TPR motif; other site 688270004622 binding surface 688270004623 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270004624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270004625 dimer interface [polypeptide binding]; other site 688270004626 phosphorylation site [posttranslational modification] 688270004627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270004628 ATP binding site [chemical binding]; other site 688270004629 Mg2+ binding site [ion binding]; other site 688270004630 G-X-G motif; other site 688270004631 Predicted membrane protein [Function unknown]; Region: COG2259 688270004632 PAS domain S-box; Region: sensory_box; TIGR00229 688270004633 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270004634 PAS fold; Region: PAS_3; pfam08447 688270004635 putative active site [active] 688270004636 heme pocket [chemical binding]; other site 688270004637 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270004638 PAS fold; Region: PAS_3; pfam08447 688270004639 putative active site [active] 688270004640 heme pocket [chemical binding]; other site 688270004641 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270004642 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 688270004643 putative active site [active] 688270004644 heme pocket [chemical binding]; other site 688270004645 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270004646 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 688270004647 putative active site [active] 688270004648 heme pocket [chemical binding]; other site 688270004649 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270004650 putative active site [active] 688270004651 heme pocket [chemical binding]; other site 688270004652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270004653 dimer interface [polypeptide binding]; other site 688270004654 phosphorylation site [posttranslational modification] 688270004655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270004656 ATP binding site [chemical binding]; other site 688270004657 Mg2+ binding site [ion binding]; other site 688270004658 G-X-G motif; other site 688270004659 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 688270004660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270004661 active site 688270004662 phosphorylation site [posttranslational modification] 688270004663 intermolecular recognition site; other site 688270004664 dimerization interface [polypeptide binding]; other site 688270004665 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 688270004666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270004667 active site 688270004668 phosphorylation site [posttranslational modification] 688270004669 intermolecular recognition site; other site 688270004670 PAS domain S-box; Region: sensory_box; TIGR00229 688270004671 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270004672 putative active site [active] 688270004673 heme pocket [chemical binding]; other site 688270004674 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 688270004675 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 688270004676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270004677 active site 688270004678 phosphorylation site [posttranslational modification] 688270004679 intermolecular recognition site; other site 688270004680 dimerization interface [polypeptide binding]; other site 688270004681 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 688270004682 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 688270004683 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 688270004684 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 688270004685 FeS/SAM binding site; other site 688270004686 HemN C-terminal domain; Region: HemN_C; pfam06969 688270004687 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 688270004688 Ligand Binding Site [chemical binding]; other site 688270004689 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 688270004690 Ligand Binding Site [chemical binding]; other site 688270004691 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 688270004692 heme-binding site [chemical binding]; other site 688270004693 Family description; Region: DsbD_2; pfam13386 688270004694 FixH; Region: FixH; pfam05751 688270004695 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 688270004696 4Fe-4S binding domain; Region: Fer4_5; pfam12801 688270004697 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 688270004698 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 688270004699 Cytochrome c; Region: Cytochrom_C; cl11414 688270004700 Cytochrome c; Region: Cytochrom_C; pfam00034 688270004701 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 688270004702 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 688270004703 Low-spin heme binding site [chemical binding]; other site 688270004704 Putative water exit pathway; other site 688270004705 Binuclear center (active site) [active] 688270004706 Putative proton exit pathway; other site 688270004707 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 688270004708 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 688270004709 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 688270004710 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 688270004711 Heavy-metal-associated domain; Region: HMA; pfam00403 688270004712 metal-binding site [ion binding] 688270004713 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 688270004714 Soluble P-type ATPase [General function prediction only]; Region: COG4087 688270004715 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 688270004716 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 688270004717 ligand binding site [chemical binding]; other site 688270004718 flexible hinge region; other site 688270004719 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 688270004720 Ligand Binding Site [chemical binding]; other site 688270004721 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 688270004722 Ligand Binding Site [chemical binding]; other site 688270004723 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 688270004724 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 688270004725 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 688270004726 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 688270004727 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 688270004728 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 688270004729 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 688270004730 Predicted membrane protein [Function unknown]; Region: COG3650 688270004731 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 688270004732 Uncharacterized conserved protein [Function unknown]; Region: COG1262 688270004733 Uncharacterized conserved protein [Function unknown]; Region: COG1262 688270004734 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 688270004735 Uncharacterized conserved protein [Function unknown]; Region: COG1262 688270004736 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 688270004737 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 688270004738 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 688270004739 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 688270004740 putative active site [active] 688270004741 putative metal binding site [ion binding]; other site 688270004742 urocanate hydratase; Provisional; Region: PRK05414 688270004743 imidazolonepropionase; Validated; Region: PRK09356 688270004744 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 688270004745 active site 688270004746 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 688270004747 active sites [active] 688270004748 tetramer interface [polypeptide binding]; other site 688270004749 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 688270004750 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 688270004751 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 688270004752 dimerization interface [polypeptide binding]; other site 688270004753 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 688270004754 FMN binding site [chemical binding]; other site 688270004755 dimer interface [polypeptide binding]; other site 688270004756 Protein of unknown function (DUF456); Region: DUF456; pfam04306 688270004757 Penicillinase repressor; Region: Pencillinase_R; pfam03965 688270004758 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 688270004759 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 688270004760 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 688270004761 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 688270004762 active site 688270004763 putative DNA-binding cleft [nucleotide binding]; other site 688270004764 dimer interface [polypeptide binding]; other site 688270004765 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 688270004766 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 688270004767 FeS/SAM binding site; other site 688270004768 HemN C-terminal domain; Region: HemN_C; pfam06969 688270004769 Putative cyclase; Region: Cyclase; pfam04199 688270004770 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 688270004771 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 688270004772 Protein of unknown function (DUF419); Region: DUF419; pfam04237 688270004773 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 688270004774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 688270004775 Walker A/P-loop; other site 688270004776 ATP binding site [chemical binding]; other site 688270004777 Q-loop/lid; other site 688270004778 ABC transporter signature motif; other site 688270004779 Walker B; other site 688270004780 D-loop; other site 688270004781 H-loop/switch region; other site 688270004782 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 688270004783 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 688270004784 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 688270004785 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 688270004786 Penicillinase repressor; Region: Pencillinase_R; cl17580 688270004787 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 688270004788 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 688270004789 PhnA protein; Region: PhnA; pfam03831 688270004790 Uncharacterized conserved protein [Function unknown]; Region: COG1432 688270004791 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 688270004792 putative metal binding site [ion binding]; other site 688270004793 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 688270004794 hypothetical protein; Provisional; Region: PRK08201 688270004795 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 688270004796 metal binding site [ion binding]; metal-binding site 688270004797 putative dimer interface [polypeptide binding]; other site 688270004798 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270004799 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270004800 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270004801 starch binding outer membrane protein SusD; Region: SusD; cd08977 688270004802 Transcriptional regulators [Transcription]; Region: FadR; COG2186 688270004803 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 688270004804 DNA-binding site [nucleotide binding]; DNA binding site 688270004805 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 688270004806 Domain of unknown function (DUF303); Region: DUF303; pfam03629 688270004807 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 688270004808 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 688270004809 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270004810 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270004811 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 688270004812 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 688270004813 starch binding outer membrane protein SusD; Region: SusD; cd08977 688270004814 Domain of unknown function (DUF377); Region: DUF377; pfam04041 688270004815 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 688270004816 active site 688270004817 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 688270004818 Na binding site [ion binding]; other site 688270004819 Haem-binding domain; Region: Haem_bd; pfam14376 688270004820 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 688270004821 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 688270004822 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 688270004823 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 688270004824 inhibitor-cofactor binding pocket; inhibition site 688270004825 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270004826 catalytic residue [active] 688270004827 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 688270004828 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 688270004829 NAD binding site [chemical binding]; other site 688270004830 homodimer interface [polypeptide binding]; other site 688270004831 active site 688270004832 substrate binding site [chemical binding]; other site 688270004833 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 688270004834 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 688270004835 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 688270004836 TPP-binding site [chemical binding]; other site 688270004837 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 688270004838 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 688270004839 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 688270004840 E3 interaction surface; other site 688270004841 lipoyl attachment site [posttranslational modification]; other site 688270004842 e3 binding domain; Region: E3_binding; pfam02817 688270004843 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 688270004844 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 688270004845 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 688270004846 catalytic motif [active] 688270004847 Catalytic residue [active] 688270004848 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 688270004849 active site 688270004850 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 688270004851 active site 688270004852 homodimer interface [polypeptide binding]; other site 688270004853 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 688270004854 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 688270004855 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 688270004856 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 688270004857 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 688270004858 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 688270004859 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 688270004860 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 688270004861 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 688270004862 putative dimer interface [polypeptide binding]; other site 688270004863 putative anticodon binding site; other site 688270004864 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 688270004865 homodimer interface [polypeptide binding]; other site 688270004866 motif 1; other site 688270004867 motif 2; other site 688270004868 active site 688270004869 motif 3; other site 688270004870 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 688270004871 Protein export membrane protein; Region: SecD_SecF; cl14618 688270004872 ribosome recycling factor; Reviewed; Region: frr; PRK00083 688270004873 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 688270004874 hinge region; other site 688270004875 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 688270004876 putative nucleotide binding site [chemical binding]; other site 688270004877 uridine monophosphate binding site [chemical binding]; other site 688270004878 homohexameric interface [polypeptide binding]; other site 688270004879 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 688270004880 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 688270004881 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 688270004882 elongation factor Ts; Provisional; Region: tsf; PRK09377 688270004883 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 688270004884 Elongation factor TS; Region: EF_TS; pfam00889 688270004885 Elongation factor TS; Region: EF_TS; pfam00889 688270004886 30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311 688270004887 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 688270004888 rRNA interaction site [nucleotide binding]; other site 688270004889 S8 interaction site; other site 688270004890 putative laminin-1 binding site; other site 688270004891 Uncharacterized conserved protein [Function unknown]; Region: COG3743 688270004892 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 688270004893 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 688270004894 23S rRNA interface [nucleotide binding]; other site 688270004895 L3 interface [polypeptide binding]; other site 688270004896 DNA polymerase I; Provisional; Region: PRK05755 688270004897 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 688270004898 active site 688270004899 metal binding site 1 [ion binding]; metal-binding site 688270004900 putative 5' ssDNA interaction site; other site 688270004901 metal binding site 3; metal-binding site 688270004902 metal binding site 2 [ion binding]; metal-binding site 688270004903 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 688270004904 putative DNA binding site [nucleotide binding]; other site 688270004905 putative metal binding site [ion binding]; other site 688270004906 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 688270004907 active site 688270004908 catalytic site [active] 688270004909 substrate binding site [chemical binding]; other site 688270004910 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 688270004911 active site 688270004912 DNA binding site [nucleotide binding] 688270004913 catalytic site [active] 688270004914 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 688270004915 active site 688270004916 dimer interface [polypeptide binding]; other site 688270004917 catalytic nucleophile [active] 688270004918 CutC family; Region: CutC; cl01218 688270004919 phosphodiesterase YaeI; Provisional; Region: PRK11340 688270004920 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 688270004921 putative active site [active] 688270004922 putative metal binding site [ion binding]; other site 688270004923 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 688270004924 catalytic residues [active] 688270004925 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 688270004926 ribosome maturation protein RimP; Reviewed; Region: PRK00092 688270004927 Sm and related proteins; Region: Sm_like; cl00259 688270004928 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 688270004929 putative oligomer interface [polypeptide binding]; other site 688270004930 putative RNA binding site [nucleotide binding]; other site 688270004931 transcription termination factor NusA; Region: NusA; TIGR01953 688270004932 NusA N-terminal domain; Region: NusA_N; pfam08529 688270004933 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 688270004934 RNA binding site [nucleotide binding]; other site 688270004935 homodimer interface [polypeptide binding]; other site 688270004936 NusA-like KH domain; Region: KH_5; pfam13184 688270004937 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 688270004938 G-X-X-G motif; other site 688270004939 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 688270004940 translation initiation factor IF-2; Region: IF-2; TIGR00487 688270004941 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 688270004942 G1 box; other site 688270004943 putative GEF interaction site [polypeptide binding]; other site 688270004944 GTP/Mg2+ binding site [chemical binding]; other site 688270004945 Switch I region; other site 688270004946 G2 box; other site 688270004947 G3 box; other site 688270004948 Switch II region; other site 688270004949 G4 box; other site 688270004950 G5 box; other site 688270004951 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 688270004952 Translation-initiation factor 2; Region: IF-2; pfam11987 688270004953 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 688270004954 Sporulation related domain; Region: SPOR; cl10051 688270004955 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 688270004956 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 688270004957 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 688270004958 heme-binding residues [chemical binding]; other site 688270004959 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 688270004960 heme-binding residues [chemical binding]; other site 688270004961 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 688270004962 molybdopterin cofactor binding site; other site 688270004963 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 688270004964 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 688270004965 4Fe-4S binding domain; Region: Fer4; cl02805 688270004966 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 688270004967 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 688270004968 Uncharacterized conserved protein [Function unknown]; Region: COG3743 688270004969 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 688270004970 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 688270004971 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 688270004972 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 688270004973 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 688270004974 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 688270004975 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 688270004976 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 688270004977 acyl-coenzyme A oxidase; Region: PLN02636 688270004978 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 688270004979 active site 688270004980 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 688270004981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 688270004982 Walker A motif; other site 688270004983 ATP binding site [chemical binding]; other site 688270004984 Walker B motif; other site 688270004985 arginine finger; other site 688270004986 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 688270004987 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 688270004988 Cytochrome P450; Region: p450; pfam00067 688270004989 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 688270004990 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 688270004991 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 688270004992 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 688270004993 Walker A/P-loop; other site 688270004994 ATP binding site [chemical binding]; other site 688270004995 Q-loop/lid; other site 688270004996 ABC transporter signature motif; other site 688270004997 Walker B; other site 688270004998 D-loop; other site 688270004999 H-loop/switch region; other site 688270005000 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 688270005001 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 688270005002 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 688270005003 Malic enzyme, N-terminal domain; Region: malic; pfam00390 688270005004 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 688270005005 putative NAD(P) binding site [chemical binding]; other site 688270005006 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 688270005007 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 688270005008 RuvA N terminal domain; Region: RuvA_N; pfam01330 688270005009 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 688270005010 cell surface protein SprA; Region: surface_SprA; TIGR04189 688270005011 Motility related/secretion protein; Region: SprA_N; pfam14349 688270005012 Motility related/secretion protein; Region: SprA_N; pfam14349 688270005013 Motility related/secretion protein; Region: SprA_N; pfam14349 688270005014 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 688270005015 lipoyl attachment site [posttranslational modification]; other site 688270005016 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 688270005017 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 688270005018 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 688270005019 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 688270005020 UbiA prenyltransferase family; Region: UbiA; pfam01040 688270005021 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 688270005022 Subunit I/III interface [polypeptide binding]; other site 688270005023 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 688270005024 Subunit I/III interface [polypeptide binding]; other site 688270005025 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 688270005026 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 688270005027 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 688270005028 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 688270005029 Cu(I) binding site [ion binding]; other site 688270005030 Protein of unknown function (DUF420); Region: DUF420; pfam04238 688270005031 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 688270005032 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 688270005033 FtsX-like permease family; Region: FtsX; pfam02687 688270005034 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 688270005035 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 688270005036 FtsX-like permease family; Region: FtsX; pfam02687 688270005037 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 688270005038 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 688270005039 HlyD family secretion protein; Region: HlyD_3; pfam13437 688270005040 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 688270005041 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 688270005042 Walker A/P-loop; other site 688270005043 ATP binding site [chemical binding]; other site 688270005044 Q-loop/lid; other site 688270005045 ABC transporter signature motif; other site 688270005046 Walker B; other site 688270005047 D-loop; other site 688270005048 H-loop/switch region; other site 688270005049 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 688270005050 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 688270005051 FtsX-like permease family; Region: FtsX; pfam02687 688270005052 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 688270005053 FtsX-like permease family; Region: FtsX; pfam02687 688270005054 macrolide transporter subunit MacA; Provisional; Region: PRK11578 688270005055 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 688270005056 HlyD family secretion protein; Region: HlyD_3; pfam13437 688270005057 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 688270005058 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 688270005059 Glycoprotease family; Region: Peptidase_M22; pfam00814 688270005060 Conserved TM helix; Region: TM_helix; pfam05552 688270005061 Mechanosensitive ion channel; Region: MS_channel; pfam00924 688270005062 Dodecin; Region: Dodecin; pfam07311 688270005063 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 688270005064 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 688270005065 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 688270005066 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 688270005067 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 688270005068 metal ion-dependent adhesion site (MIDAS); other site 688270005069 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270005070 binding surface 688270005071 TPR motif; other site 688270005072 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270005073 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270005074 Histidine kinase; Region: His_kinase; pfam06580 688270005075 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 688270005076 ATP binding site [chemical binding]; other site 688270005077 Mg2+ binding site [ion binding]; other site 688270005078 G-X-G motif; other site 688270005079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270005080 Response regulator receiver domain; Region: Response_reg; pfam00072 688270005081 active site 688270005082 phosphorylation site [posttranslational modification] 688270005083 intermolecular recognition site; other site 688270005084 dimerization interface [polypeptide binding]; other site 688270005085 LytTr DNA-binding domain; Region: LytTR; smart00850 688270005086 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 688270005087 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 688270005088 trimer interface [polypeptide binding]; other site 688270005089 putative metal binding site [ion binding]; other site 688270005090 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 688270005091 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 688270005092 Calx-beta domain; Region: Calx-beta; cl02522 688270005093 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 688270005094 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 688270005095 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 688270005096 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 688270005097 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 688270005098 ligand binding site [chemical binding]; other site 688270005099 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 688270005100 putative active site [active] 688270005101 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 688270005102 Active site serine [active] 688270005103 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 688270005104 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 688270005105 putative active site [active] 688270005106 Zn binding site [ion binding]; other site 688270005107 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 688270005108 ATP-grasp domain; Region: ATP-grasp_4; cl17255 688270005109 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 688270005110 active site 688270005111 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 688270005112 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 688270005113 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 688270005114 active site 688270005115 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 688270005116 MutS domain I; Region: MutS_I; pfam01624 688270005117 MutS domain II; Region: MutS_II; pfam05188 688270005118 MutS domain III; Region: MutS_III; pfam05192 688270005119 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 688270005120 Walker A/P-loop; other site 688270005121 ATP binding site [chemical binding]; other site 688270005122 Q-loop/lid; other site 688270005123 ABC transporter signature motif; other site 688270005124 Walker B; other site 688270005125 D-loop; other site 688270005126 H-loop/switch region; other site 688270005127 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 688270005128 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 688270005129 catalytic center binding site [active] 688270005130 ATP binding site [chemical binding]; other site 688270005131 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 688270005132 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 688270005133 Substrate-binding site [chemical binding]; other site 688270005134 Substrate specificity [chemical binding]; other site 688270005135 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 688270005136 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 688270005137 tandem repeat interface [polypeptide binding]; other site 688270005138 oligomer interface [polypeptide binding]; other site 688270005139 active site residues [active] 688270005140 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 688270005141 tandem repeat interface [polypeptide binding]; other site 688270005142 oligomer interface [polypeptide binding]; other site 688270005143 active site residues [active] 688270005144 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 688270005145 Protein of unknown function; Region: DUF3971; pfam13116 688270005146 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 688270005147 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 688270005148 GH3 auxin-responsive promoter; Region: GH3; pfam03321 688270005149 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 688270005150 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 688270005151 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 688270005152 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 688270005153 Walker A motif; other site 688270005154 ATP binding site [chemical binding]; other site 688270005155 Walker B motif; other site 688270005156 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 688270005157 Clp protease; Region: CLP_protease; pfam00574 688270005158 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 688270005159 oligomer interface [polypeptide binding]; other site 688270005160 active site residues [active] 688270005161 trigger factor; Provisional; Region: tig; PRK01490 688270005162 Membrane protein of unknown function; Region: DUF360; pfam04020 688270005163 PGAP1-like protein; Region: PGAP1; pfam07819 688270005164 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 688270005165 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 688270005166 active site 688270005167 hydrophilic channel; other site 688270005168 dimerization interface [polypeptide binding]; other site 688270005169 catalytic residues [active] 688270005170 active site lid [active] 688270005171 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 688270005172 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01911 688270005173 ATP-NAD kinase; Region: NAD_kinase; pfam01513 688270005174 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 688270005175 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 688270005176 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 688270005177 catalytic residue [active] 688270005178 putative FPP diphosphate binding site; other site 688270005179 putative FPP binding hydrophobic cleft; other site 688270005180 dimer interface [polypeptide binding]; other site 688270005181 putative IPP diphosphate binding site; other site 688270005182 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 688270005183 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 688270005184 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 688270005185 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 688270005186 Surface antigen; Region: Bac_surface_Ag; pfam01103 688270005187 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 688270005188 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 688270005189 glutamate racemase; Provisional; Region: PRK00865 688270005190 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 688270005191 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 688270005192 folate binding site [chemical binding]; other site 688270005193 NADP+ binding site [chemical binding]; other site 688270005194 2TM domain; Region: 2TM; pfam13239 688270005195 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 688270005196 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 688270005197 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 688270005198 catalytic residue [active] 688270005199 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 688270005200 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 688270005201 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 688270005202 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 688270005203 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 688270005204 thymidylate synthase; Reviewed; Region: thyA; PRK01827 688270005205 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 688270005206 dimerization interface [polypeptide binding]; other site 688270005207 active site 688270005208 nucleoside transporter; Region: nupC; TIGR00804 688270005209 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 688270005210 Nucleoside recognition; Region: Gate; pfam07670 688270005211 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 688270005212 Bifunctional nuclease; Region: DNase-RNase; pfam02577 688270005213 UvrB/uvrC motif; Region: UVR; pfam02151 688270005214 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 688270005215 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 688270005216 Ligand binding site [chemical binding]; other site 688270005217 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 688270005218 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 688270005219 Ligand binding site [chemical binding]; other site 688270005220 Electron transfer flavoprotein domain; Region: ETF; pfam01012 688270005221 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 688270005222 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 688270005223 alpha subunit interface [polypeptide binding]; other site 688270005224 TPP binding site [chemical binding]; other site 688270005225 heterodimer interface [polypeptide binding]; other site 688270005226 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 688270005227 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270005228 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 688270005229 dimer interface [polypeptide binding]; other site 688270005230 substrate binding site [chemical binding]; other site 688270005231 metal binding sites [ion binding]; metal-binding site 688270005232 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 688270005233 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 688270005234 Uncharacterized conserved protein [Function unknown]; Region: COG4850 688270005235 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 688270005236 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 688270005237 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 688270005238 Substrate-binding site [chemical binding]; other site 688270005239 Substrate specificity [chemical binding]; other site 688270005240 GLPGLI family protein; Region: GLPGLI; TIGR01200 688270005241 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 688270005242 S-adenosylmethionine synthetase; Validated; Region: PRK05250 688270005243 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 688270005244 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 688270005245 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 688270005246 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 688270005247 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 688270005248 homodimer interface [polypeptide binding]; other site 688270005249 substrate-cofactor binding pocket; other site 688270005250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270005251 catalytic residue [active] 688270005252 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 688270005253 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 688270005254 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 688270005255 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 688270005256 nucleotide binding site [chemical binding]; other site 688270005257 substrate binding site [chemical binding]; other site 688270005258 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 688270005259 dimer interface [polypeptide binding]; other site 688270005260 putative threonine allosteric regulatory site; other site 688270005261 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 688270005262 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 688270005263 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 688270005264 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 688270005265 homodimer interface [polypeptide binding]; other site 688270005266 substrate-cofactor binding pocket; other site 688270005267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270005268 catalytic residue [active] 688270005269 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 688270005270 Rrf2 family protein; Region: rrf2_super; TIGR00738 688270005271 Transcriptional regulator; Region: Rrf2; pfam02082 688270005272 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 688270005273 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 688270005274 Active Sites [active] 688270005275 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 688270005276 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 688270005277 Active Sites [active] 688270005278 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 688270005279 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 688270005280 CysD dimerization site [polypeptide binding]; other site 688270005281 G1 box; other site 688270005282 putative GEF interaction site [polypeptide binding]; other site 688270005283 GTP/Mg2+ binding site [chemical binding]; other site 688270005284 Switch I region; other site 688270005285 G2 box; other site 688270005286 G3 box; other site 688270005287 Switch II region; other site 688270005288 G4 box; other site 688270005289 G5 box; other site 688270005290 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 688270005291 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 688270005292 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 688270005293 precorrin-3B synthase; Region: CobG; TIGR02435 688270005294 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 688270005295 HEPN domain; Region: HEPN; cl00824 688270005296 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 688270005297 active site 688270005298 SAM binding site [chemical binding]; other site 688270005299 homodimer interface [polypeptide binding]; other site 688270005300 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 688270005301 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 688270005302 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 688270005303 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 688270005304 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 688270005305 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 688270005306 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 688270005307 substrate binding pocket [chemical binding]; other site 688270005308 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 688270005309 B12 binding site [chemical binding]; other site 688270005310 cobalt ligand [ion binding]; other site 688270005311 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 688270005312 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 688270005313 FAD binding site [chemical binding]; other site 688270005314 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 688270005315 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 688270005316 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 688270005317 Beta-lactamase; Region: Beta-lactamase; pfam00144 688270005318 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 688270005319 Prephenate dehydratase; Region: PDT; pfam00800 688270005320 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 688270005321 putative L-Phe binding site [chemical binding]; other site 688270005322 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 688270005323 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 688270005324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270005325 homodimer interface [polypeptide binding]; other site 688270005326 catalytic residue [active] 688270005327 prephenate dehydrogenase; Validated; Region: PRK08507 688270005328 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 688270005329 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 688270005330 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 688270005331 Chorismate mutase type II; Region: CM_2; smart00830 688270005332 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 688270005333 GTPase RsgA; Reviewed; Region: PRK00098 688270005334 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 688270005335 RNA binding site [nucleotide binding]; other site 688270005336 homodimer interface [polypeptide binding]; other site 688270005337 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 688270005338 GTPase/Zn-binding domain interface [polypeptide binding]; other site 688270005339 GTP/Mg2+ binding site [chemical binding]; other site 688270005340 G4 box; other site 688270005341 G5 box; other site 688270005342 G1 box; other site 688270005343 Switch I region; other site 688270005344 G2 box; other site 688270005345 G3 box; other site 688270005346 Switch II region; other site 688270005347 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 688270005348 putative active site [active] 688270005349 dimerization interface [polypeptide binding]; other site 688270005350 putative tRNAtyr binding site [nucleotide binding]; other site 688270005351 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 688270005352 homodimer interface [polypeptide binding]; other site 688270005353 metal binding site [ion binding]; metal-binding site 688270005354 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 688270005355 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 688270005356 hinge; other site 688270005357 active site 688270005358 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 688270005359 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 688270005360 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 688270005361 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 688270005362 FeS/SAM binding site; other site 688270005363 Surface lipoprotein of Spirochaetales order; Region: Lipl32; pfam12103 688270005364 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 688270005365 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 688270005366 substrate binding pocket [chemical binding]; other site 688270005367 chain length determination region; other site 688270005368 substrate-Mg2+ binding site; other site 688270005369 catalytic residues [active] 688270005370 aspartate-rich region 1; other site 688270005371 active site lid residues [active] 688270005372 aspartate-rich region 2; other site 688270005373 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 688270005374 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 688270005375 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270005376 DNA binding residues [nucleotide binding] 688270005377 DNA primase, catalytic core; Region: dnaG; TIGR01391 688270005378 CHC2 zinc finger; Region: zf-CHC2; pfam01807 688270005379 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 688270005380 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 688270005381 active site 688270005382 metal binding site [ion binding]; metal-binding site 688270005383 interdomain interaction site; other site 688270005384 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 688270005385 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 688270005386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270005387 active site 688270005388 phosphorylation site [posttranslational modification] 688270005389 intermolecular recognition site; other site 688270005390 dimerization interface [polypeptide binding]; other site 688270005391 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 688270005392 DNA binding residues [nucleotide binding] 688270005393 dimerization interface [polypeptide binding]; other site 688270005394 NAD synthetase; Provisional; Region: PRK13980 688270005395 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 688270005396 homodimer interface [polypeptide binding]; other site 688270005397 NAD binding pocket [chemical binding]; other site 688270005398 ATP binding pocket [chemical binding]; other site 688270005399 Mg binding site [ion binding]; other site 688270005400 active-site loop [active] 688270005401 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 688270005402 gliding motility-associated protein GldC; Region: GldC; TIGR03515 688270005403 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 688270005404 G1 box; other site 688270005405 GTP/Mg2+ binding site [chemical binding]; other site 688270005406 Switch I region; other site 688270005407 G2 box; other site 688270005408 G3 box; other site 688270005409 Switch II region; other site 688270005410 G4 box; other site 688270005411 G5 box; other site 688270005412 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 688270005413 cell division protein MraZ; Reviewed; Region: PRK00326 688270005414 MraZ protein; Region: MraZ; pfam02381 688270005415 MraW methylase family; Region: Methyltransf_5; cl17771 688270005416 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 688270005417 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 688270005418 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 688270005419 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 688270005420 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 688270005421 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 688270005422 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 688270005423 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 688270005424 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 688270005425 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 688270005426 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 688270005427 Mg++ binding site [ion binding]; other site 688270005428 putative catalytic motif [active] 688270005429 putative substrate binding site [chemical binding]; other site 688270005430 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 688270005431 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 688270005432 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 688270005433 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 688270005434 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 688270005435 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 688270005436 active site 688270005437 homodimer interface [polypeptide binding]; other site 688270005438 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 688270005439 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 688270005440 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 688270005441 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 688270005442 cell division protein FtsA; Region: ftsA; TIGR01174 688270005443 Cell division protein FtsA; Region: FtsA; smart00842 688270005444 Cell division protein FtsA; Region: FtsA; pfam14450 688270005445 cell division protein FtsZ; Validated; Region: PRK09330 688270005446 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 688270005447 nucleotide binding site [chemical binding]; other site 688270005448 SulA interaction site; other site 688270005449 Yqey-like protein; Region: YqeY; pfam09424 688270005450 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 688270005451 GIY-YIG motif/motif A; other site 688270005452 putative active site [active] 688270005453 putative metal binding site [ion binding]; other site 688270005454 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 688270005455 GIY-YIG motif/motif A; other site 688270005456 putative active site [active] 688270005457 putative metal binding site [ion binding]; other site 688270005458 Transglycosylase; Region: Transgly; pfam00912 688270005459 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 688270005460 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 688270005461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270005462 active site 688270005463 phosphorylation site [posttranslational modification] 688270005464 intermolecular recognition site; other site 688270005465 dimerization interface [polypeptide binding]; other site 688270005466 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 688270005467 DNA binding residues [nucleotide binding] 688270005468 dimerization interface [polypeptide binding]; other site 688270005469 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270005470 binding surface 688270005471 TPR motif; other site 688270005472 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 688270005473 Histidine kinase; Region: HisKA_3; pfam07730 688270005474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270005475 ATP binding site [chemical binding]; other site 688270005476 Mg2+ binding site [ion binding]; other site 688270005477 G-X-G motif; other site 688270005478 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 688270005479 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 688270005480 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 688270005481 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 688270005482 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 688270005483 substrate binding site [chemical binding]; other site 688270005484 hexamer interface [polypeptide binding]; other site 688270005485 metal binding site [ion binding]; metal-binding site 688270005486 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 688270005487 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 688270005488 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 688270005489 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 688270005490 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 688270005491 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 688270005492 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270005493 DNA binding residues [nucleotide binding] 688270005494 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 688270005495 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 688270005496 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 688270005497 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 688270005498 RNase E interface [polypeptide binding]; other site 688270005499 trimer interface [polypeptide binding]; other site 688270005500 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 688270005501 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 688270005502 RNase E interface [polypeptide binding]; other site 688270005503 trimer interface [polypeptide binding]; other site 688270005504 active site 688270005505 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 688270005506 putative nucleic acid binding region [nucleotide binding]; other site 688270005507 G-X-X-G motif; other site 688270005508 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 688270005509 RNA binding site [nucleotide binding]; other site 688270005510 domain interface; other site 688270005511 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 688270005512 16S/18S rRNA binding site [nucleotide binding]; other site 688270005513 S13e-L30e interaction site [polypeptide binding]; other site 688270005514 25S rRNA binding site [nucleotide binding]; other site 688270005515 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 688270005516 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 688270005517 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 688270005518 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 688270005519 active site 688270005520 intersubunit interface [polypeptide binding]; other site 688270005521 zinc binding site [ion binding]; other site 688270005522 Na+ binding site [ion binding]; other site 688270005523 Surface antigen; Region: Bac_surface_Ag; pfam01103 688270005524 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 688270005525 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 688270005526 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 688270005527 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 688270005528 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 688270005529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 688270005530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 688270005531 S-adenosylmethionine binding site [chemical binding]; other site 688270005532 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 688270005533 TrkA-N domain; Region: TrkA_N; pfam02254 688270005534 TrkA-C domain; Region: TrkA_C; pfam02080 688270005535 TrkA-N domain; Region: TrkA_N; pfam02254 688270005536 TrkA-C domain; Region: TrkA_C; pfam02080 688270005537 Cation transport protein; Region: TrkH; cl17365 688270005538 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 688270005539 aspartate aminotransferase; Provisional; Region: PRK05764 688270005540 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 688270005541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270005542 homodimer interface [polypeptide binding]; other site 688270005543 catalytic residue [active] 688270005544 Fatty acid desaturase; Region: FA_desaturase; pfam00487 688270005545 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 688270005546 putative di-iron ligands [ion binding]; other site 688270005547 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 688270005548 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 688270005549 DinB family; Region: DinB; cl17821 688270005550 DinB superfamily; Region: DinB_2; pfam12867 688270005551 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 688270005552 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 688270005553 Glutamate binding site [chemical binding]; other site 688270005554 NAD binding site [chemical binding]; other site 688270005555 catalytic residues [active] 688270005556 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 688270005557 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 688270005558 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 688270005559 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 688270005560 FMN-binding domain; Region: FMN_bind; cl01081 688270005561 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 688270005562 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 688270005563 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 688270005564 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 688270005565 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 688270005566 catalytic loop [active] 688270005567 iron binding site [ion binding]; other site 688270005568 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 688270005569 FAD binding pocket [chemical binding]; other site 688270005570 FAD binding motif [chemical binding]; other site 688270005571 phosphate binding motif [ion binding]; other site 688270005572 beta-alpha-beta structure motif; other site 688270005573 NAD binding pocket [chemical binding]; other site 688270005574 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 688270005575 ApbE family; Region: ApbE; pfam02424 688270005576 Methyltransferase domain; Region: Methyltransf_23; pfam13489 688270005577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 688270005578 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 688270005579 active site 688270005580 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 688270005581 phosphoglyceromutase; Provisional; Region: PRK05434 688270005582 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 688270005583 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 688270005584 Transposase IS200 like; Region: Y1_Tnp; pfam01797 688270005585 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 688270005586 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 688270005587 Coenzyme A binding pocket [chemical binding]; other site 688270005588 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 688270005589 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 688270005590 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 688270005591 active site pocket [active] 688270005592 oxyanion hole [active] 688270005593 catalytic triad [active] 688270005594 active site nucleophile [active] 688270005595 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270005596 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270005597 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270005598 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270005599 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 688270005600 Zn binding site [ion binding]; other site 688270005601 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 688270005602 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 688270005603 active site 688270005604 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 688270005605 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 688270005606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 688270005607 S-adenosylmethionine binding site [chemical binding]; other site 688270005608 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 688270005609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 688270005610 Coenzyme A binding pocket [chemical binding]; other site 688270005611 kynureninase; Region: kynureninase; TIGR01814 688270005612 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 688270005613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 688270005614 putative substrate translocation pore; other site 688270005615 Astacin (Peptidase family M12A); Region: Astacin; pfam01400 688270005616 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 688270005617 active site 688270005618 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 688270005619 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270005620 Clp protease; Region: CLP_protease; pfam00574 688270005621 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 688270005622 oligomer interface [polypeptide binding]; other site 688270005623 active site residues [active] 688270005624 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 688270005625 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 688270005626 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 688270005627 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 688270005628 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 688270005629 Putative zinc ribbon domain; Region: DUF164; pfam02591 688270005630 Uncharacterized conserved protein [Function unknown]; Region: COG0327 688270005631 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 688270005632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 688270005633 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 688270005634 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 688270005635 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 688270005636 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270005637 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270005638 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270005639 binding surface 688270005640 TPR motif; other site 688270005641 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270005642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270005643 dimer interface [polypeptide binding]; other site 688270005644 phosphorylation site [posttranslational modification] 688270005645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270005646 ATP binding site [chemical binding]; other site 688270005647 Mg2+ binding site [ion binding]; other site 688270005648 G-X-G motif; other site 688270005649 Response regulator receiver domain; Region: Response_reg; pfam00072 688270005650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270005651 active site 688270005652 phosphorylation site [posttranslational modification] 688270005653 intermolecular recognition site; other site 688270005654 dimerization interface [polypeptide binding]; other site 688270005655 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 688270005656 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 688270005657 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 688270005658 lipoyl synthase; Provisional; Region: PRK05481 688270005659 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 688270005660 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270005661 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 688270005662 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 688270005663 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270005664 DNA binding residues [nucleotide binding] 688270005665 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 688270005666 FAD binding domain; Region: FAD_binding_4; pfam01565 688270005667 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 688270005668 aspartate aminotransferase; Provisional; Region: PRK07568 688270005669 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 688270005670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270005671 homodimer interface [polypeptide binding]; other site 688270005672 catalytic residue [active] 688270005673 Aspartyl protease; Region: Asp_protease_2; pfam13650 688270005674 Aspartyl protease; Region: Asp_protease_2; pfam13650 688270005675 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 688270005676 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 688270005677 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 688270005678 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 688270005679 active site 688270005680 HIGH motif; other site 688270005681 nucleotide binding site [chemical binding]; other site 688270005682 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 688270005683 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 688270005684 active site 688270005685 KMSKS motif; other site 688270005686 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 688270005687 tRNA binding surface [nucleotide binding]; other site 688270005688 anticodon binding site; other site 688270005689 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 688270005690 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 688270005691 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 688270005692 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 688270005693 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270005694 NAD(P) binding site [chemical binding]; other site 688270005695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270005696 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 688270005697 active site 688270005698 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 688270005699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270005700 active site 688270005701 phosphorylation site [posttranslational modification] 688270005702 intermolecular recognition site; other site 688270005703 dimerization interface [polypeptide binding]; other site 688270005704 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 688270005705 DNA binding site [nucleotide binding] 688270005706 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 688270005707 acyl-CoA binding pocket [chemical binding]; other site 688270005708 CoA binding site [chemical binding]; other site 688270005709 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 688270005710 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 688270005711 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 688270005712 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 688270005713 FtsH Extracellular; Region: FtsH_ext; pfam06480 688270005714 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 688270005715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 688270005716 Walker A motif; other site 688270005717 ATP binding site [chemical binding]; other site 688270005718 Walker B motif; other site 688270005719 arginine finger; other site 688270005720 Peptidase family M41; Region: Peptidase_M41; pfam01434 688270005721 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 688270005722 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 688270005723 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 688270005724 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 688270005725 active site 688270005726 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 688270005727 active site 688270005728 Ap6A binding site [chemical binding]; other site 688270005729 nudix motif; other site 688270005730 metal binding site [ion binding]; metal-binding site 688270005731 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 688270005732 putative active site [active] 688270005733 Zn binding site [ion binding]; other site 688270005734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270005735 phosphorylation site [posttranslational modification] 688270005736 intermolecular recognition site; other site 688270005737 PAS fold; Region: PAS_3; pfam08447 688270005738 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 688270005739 PAS fold; Region: PAS_4; pfam08448 688270005740 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270005741 putative active site [active] 688270005742 heme pocket [chemical binding]; other site 688270005743 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270005744 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270005745 ATP binding site [chemical binding]; other site 688270005746 Mg2+ binding site [ion binding]; other site 688270005747 G-X-G motif; other site 688270005748 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 688270005749 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 688270005750 active site 688270005751 (T/H)XGH motif; other site 688270005752 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 688270005753 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 688270005754 ATP-grasp domain; Region: ATP-grasp_4; cl17255 688270005755 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 688270005756 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 688270005757 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 688270005758 RNA binding surface [nucleotide binding]; other site 688270005759 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 688270005760 active site 688270005761 hypothetical protein; Validated; Region: PRK02101 688270005762 pyruvate carboxylase; Reviewed; Region: PRK12999 688270005763 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 688270005764 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 688270005765 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 688270005766 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 688270005767 active site 688270005768 catalytic residues [active] 688270005769 metal binding site [ion binding]; metal-binding site 688270005770 homodimer binding site [polypeptide binding]; other site 688270005771 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 688270005772 carboxyltransferase (CT) interaction site; other site 688270005773 biotinylation site [posttranslational modification]; other site 688270005774 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 688270005775 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 688270005776 putative active site [active] 688270005777 Electron transfer DM13; Region: DM13; cl02735 688270005778 hypothetical protein; Provisional; Region: PRK08201 688270005779 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_1; cd05678 688270005780 putative metal binding site [ion binding]; other site 688270005781 putative dimer interface [polypeptide binding]; other site 688270005782 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 688270005783 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 688270005784 substrate binding site [chemical binding]; other site 688270005785 active site 688270005786 catalytic residues [active] 688270005787 heterodimer interface [polypeptide binding]; other site 688270005788 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 688270005789 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 688270005790 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270005791 catalytic residue [active] 688270005792 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 688270005793 active site 688270005794 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 688270005795 active site 688270005796 ribulose/triose binding site [chemical binding]; other site 688270005797 phosphate binding site [ion binding]; other site 688270005798 substrate (anthranilate) binding pocket [chemical binding]; other site 688270005799 product (indole) binding pocket [chemical binding]; other site 688270005800 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 688270005801 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 688270005802 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 688270005803 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 688270005804 Glutamine amidotransferase class-I; Region: GATase; pfam00117 688270005805 glutamine binding [chemical binding]; other site 688270005806 catalytic triad [active] 688270005807 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 688270005808 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 688270005809 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 688270005810 YceI-like domain; Region: YceI; pfam04264 688270005811 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 688270005812 dimer interface [polypeptide binding]; other site 688270005813 FMN binding site [chemical binding]; other site 688270005814 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 688270005815 MarR family; Region: MarR; pfam01047 688270005816 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 688270005817 active site residue [active] 688270005818 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 688270005819 PspC domain; Region: PspC; cl00864 688270005820 Ion channel; Region: Ion_trans_2; pfam07885 688270005821 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 688270005822 TrkA-N domain; Region: TrkA_N; pfam02254 688270005823 TrkA-C domain; Region: TrkA_C; pfam02080 688270005824 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 688270005825 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 688270005826 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 688270005827 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 688270005828 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 688270005829 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 688270005830 active site 688270005831 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 688270005832 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 688270005833 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 688270005834 active site 688270005835 DNA binding site [nucleotide binding] 688270005836 Int/Topo IB signature motif; other site 688270005837 elongation factor Tu; Reviewed; Region: PRK12735 688270005838 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 688270005839 G1 box; other site 688270005840 GEF interaction site [polypeptide binding]; other site 688270005841 GTP/Mg2+ binding site [chemical binding]; other site 688270005842 Switch I region; other site 688270005843 G2 box; other site 688270005844 G3 box; other site 688270005845 Switch II region; other site 688270005846 G4 box; other site 688270005847 G5 box; other site 688270005848 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 688270005849 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 688270005850 Antibiotic Binding Site [chemical binding]; other site 688270005851 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 688270005852 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 688270005853 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 688270005854 putative homodimer interface [polypeptide binding]; other site 688270005855 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 688270005856 heterodimer interface [polypeptide binding]; other site 688270005857 homodimer interface [polypeptide binding]; other site 688270005858 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 688270005859 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 688270005860 23S rRNA interface [nucleotide binding]; other site 688270005861 L7/L12 interface [polypeptide binding]; other site 688270005862 putative thiostrepton binding site; other site 688270005863 L25 interface [polypeptide binding]; other site 688270005864 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 688270005865 mRNA/rRNA interface [nucleotide binding]; other site 688270005866 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 688270005867 23S rRNA interface [nucleotide binding]; other site 688270005868 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 688270005869 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 688270005870 core dimer interface [polypeptide binding]; other site 688270005871 peripheral dimer interface [polypeptide binding]; other site 688270005872 L10 interface [polypeptide binding]; other site 688270005873 L11 interface [polypeptide binding]; other site 688270005874 putative EF-Tu interaction site [polypeptide binding]; other site 688270005875 putative EF-G interaction site [polypeptide binding]; other site 688270005876 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 688270005877 DNA-directed RNA polymerase subunit B''; Validated; Region: PRK09606 688270005878 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 688270005879 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 688270005880 RPB11 interaction site [polypeptide binding]; other site 688270005881 RPB12 interaction site [polypeptide binding]; other site 688270005882 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 688270005883 RPB3 interaction site [polypeptide binding]; other site 688270005884 RPB1 interaction site [polypeptide binding]; other site 688270005885 RPB11 interaction site [polypeptide binding]; other site 688270005886 RPB10 interaction site [polypeptide binding]; other site 688270005887 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 688270005888 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 688270005889 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 688270005890 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 688270005891 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 688270005892 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 688270005893 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 688270005894 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 688270005895 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 688270005896 DNA binding site [nucleotide binding] 688270005897 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 688270005898 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 688270005899 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 688270005900 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 688270005901 G1 box; other site 688270005902 putative GEF interaction site [polypeptide binding]; other site 688270005903 GTP/Mg2+ binding site [chemical binding]; other site 688270005904 Switch I region; other site 688270005905 G2 box; other site 688270005906 G3 box; other site 688270005907 Switch II region; other site 688270005908 G4 box; other site 688270005909 G5 box; other site 688270005910 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 688270005911 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 688270005912 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 688270005913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270005914 binding surface 688270005915 Tetratricopeptide repeat; Region: TPR_16; pfam13432 688270005916 TPR motif; other site 688270005917 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 688270005918 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 688270005919 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 688270005920 ligand binding site [chemical binding]; other site 688270005921 Calx-beta domain; Region: Calx-beta; pfam03160 688270005922 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041 688270005923 heterodimerization interface [polypeptide binding]; other site 688270005924 Calx-beta domain; Region: Calx-beta; cl02522 688270005925 Right handed beta helix region; Region: Beta_helix; pfam13229 688270005926 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 688270005927 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 688270005928 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 688270005929 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 688270005930 active site 688270005931 metal binding site [ion binding]; metal-binding site 688270005932 nudix motif; other site 688270005933 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 688270005934 active site 688270005935 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 688270005936 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 688270005937 ligand binding site [chemical binding]; other site 688270005938 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 688270005939 Protein of unknown function (DUF819); Region: DUF819; cl02317 688270005940 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 688270005941 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 688270005942 active site 688270005943 motif I; other site 688270005944 motif II; other site 688270005945 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 688270005946 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 688270005947 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 688270005948 putative ligand binding site [chemical binding]; other site 688270005949 Transglycosylase; Region: Transgly; pfam00912 688270005950 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 688270005951 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 688270005952 active site 688270005953 Zn binding site [ion binding]; other site 688270005954 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 688270005955 Cupin domain; Region: Cupin_2; pfam07883 688270005956 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 688270005957 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 688270005958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 688270005959 MOSC domain; Region: MOSC; pfam03473 688270005960 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 688270005961 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 688270005962 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270005963 DNA binding residues [nucleotide binding] 688270005964 Predicted membrane protein [Function unknown]; Region: COG4270 688270005965 heat shock protein 90; Provisional; Region: PRK05218 688270005966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270005967 ATP binding site [chemical binding]; other site 688270005968 Mg2+ binding site [ion binding]; other site 688270005969 G-X-G motif; other site 688270005970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 688270005971 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 688270005972 ABC1 family; Region: ABC1; cl17513 688270005973 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 688270005974 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 688270005975 dimer interface [polypeptide binding]; other site 688270005976 active site 688270005977 CoA binding pocket [chemical binding]; other site 688270005978 Integrase core domain; Region: rve; pfam00665 688270005979 Integrase core domain; Region: rve_3; pfam13683 688270005980 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270005981 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 688270005982 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270005983 CoA binding domain; Region: CoA_binding_2; pfam13380 688270005984 recombination protein RecR; Reviewed; Region: recR; PRK00076 688270005985 RecR protein; Region: RecR; pfam02132 688270005986 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 688270005987 putative active site [active] 688270005988 putative metal-binding site [ion binding]; other site 688270005989 tetramer interface [polypeptide binding]; other site 688270005990 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 688270005991 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 688270005992 E3 interaction surface; other site 688270005993 lipoyl attachment site [posttranslational modification]; other site 688270005994 e3 binding domain; Region: E3_binding; pfam02817 688270005995 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 688270005996 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 688270005997 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 688270005998 active site 688270005999 catalytic site [active] 688270006000 substrate binding site [chemical binding]; other site 688270006001 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270006002 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 688270006003 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 688270006004 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 688270006005 putative binding surface; other site 688270006006 active site 688270006007 competence damage-inducible protein A; Provisional; Region: PRK00549 688270006008 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 688270006009 putative MPT binding site; other site 688270006010 Competence-damaged protein; Region: CinA; pfam02464 688270006011 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 688270006012 ribosomal protein L33; Region: rpl33; CHL00104 688270006013 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 688270006014 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 688270006015 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 688270006016 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 688270006017 amidase; Provisional; Region: PRK06707 688270006018 Amidase; Region: Amidase; cl11426 688270006019 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 688270006020 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 688270006021 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 688270006022 FeS/SAM binding site; other site 688270006023 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 688270006024 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 688270006025 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 688270006026 SurA N-terminal domain; Region: SurA_N; pfam09312 688270006027 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 688270006028 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 688270006029 MoxR-like ATPases [General function prediction only]; Region: COG0714 688270006030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 688270006031 Walker A motif; other site 688270006032 ATP binding site [chemical binding]; other site 688270006033 Walker B motif; other site 688270006034 arginine finger; other site 688270006035 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 688270006036 Aconitate hydratase 2 N-terminus; Region: Aconitase_2_N; pfam06434 688270006037 substrate binding site [chemical binding]; other site 688270006038 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 688270006039 substrate binding site [chemical binding]; other site 688270006040 ligand binding site [chemical binding]; other site 688270006041 aconitate hydratase; Validated; Region: PRK07229 688270006042 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 688270006043 substrate binding site [chemical binding]; other site 688270006044 ligand binding site [chemical binding]; other site 688270006045 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 688270006046 substrate binding site [chemical binding]; other site 688270006047 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 688270006048 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 688270006049 catalytic residues [active] 688270006050 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 688270006051 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 688270006052 catalytic residues [active] 688270006053 beta-carotene hydroxylase; Region: PLN02601 688270006054 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 688270006055 active site lid residues [active] 688270006056 substrate binding pocket [chemical binding]; other site 688270006057 catalytic residues [active] 688270006058 substrate-Mg2+ binding site; other site 688270006059 aspartate-rich region 1; other site 688270006060 aspartate-rich region 2; other site 688270006061 phytoene desaturase; Region: crtI_fam; TIGR02734 688270006062 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 688270006063 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 688270006064 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 688270006065 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 688270006066 DNA binding residues [nucleotide binding] 688270006067 B12 binding domain; Region: B12-binding_2; pfam02607 688270006068 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 688270006069 DNA-binding site [nucleotide binding]; DNA binding site 688270006070 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 688270006071 putative dimerization interface [polypeptide binding]; other site 688270006072 putative ligand binding site [chemical binding]; other site 688270006073 Transcriptional regulators [Transcription]; Region: PurR; COG1609 688270006074 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 688270006075 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 688270006076 nucleotide binding site [chemical binding]; other site 688270006077 xylose isomerase; Provisional; Region: PRK05474 688270006078 xylose isomerase; Region: xylose_isom_A; TIGR02630 688270006079 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 688270006080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 688270006081 putative substrate translocation pore; other site 688270006082 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 688270006083 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 688270006084 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 688270006085 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 688270006086 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 688270006087 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 688270006088 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 688270006089 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 688270006090 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 688270006091 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 688270006092 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 688270006093 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 688270006094 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 688270006095 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 688270006096 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 688270006097 Family description; Region: VCBS; pfam13517 688270006098 Family description; Region: VCBS; pfam13517 688270006099 Family description; Region: VCBS; pfam13517 688270006100 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 688270006101 Family description; Region: VCBS; pfam13517 688270006102 Family description; Region: VCBS; pfam13517 688270006103 Family description; Region: VCBS; pfam13517 688270006104 Family description; Region: VCBS; pfam13517 688270006105 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 688270006106 SusD family; Region: SusD; pfam07980 688270006107 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270006108 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270006109 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 688270006110 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270006111 Beta-agarase, member of glycosyl hydrolase family 16; Region: GH16_beta_agarase; cd02178 688270006112 calcium binding site [ion binding]; other site 688270006113 active site 688270006114 catalytic residues [active] 688270006115 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 688270006116 Sulfatase; Region: Sulfatase; cl17466 688270006117 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 688270006118 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 688270006119 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 688270006120 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 688270006121 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 688270006122 Sulfatase; Region: Sulfatase; pfam00884 688270006123 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 688270006124 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 688270006125 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 688270006126 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 688270006127 Sulfatase; Region: Sulfatase; cl17466 688270006128 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 688270006129 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 688270006130 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 688270006131 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 688270006132 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 688270006133 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 688270006134 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 688270006135 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 688270006136 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 688270006137 active site 688270006138 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 688270006139 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 688270006140 Right handed beta helix region; Region: Beta_helix; pfam13229 688270006141 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 688270006142 active site 688270006143 catalytic residues [active] 688270006144 Sulfatase; Region: Sulfatase; cl17466 688270006145 Sulfatase; Region: Sulfatase; cl17466 688270006146 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 688270006147 HEAT repeats; Region: HEAT_2; pfam13646 688270006148 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 688270006149 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 688270006150 Sulfatase; Region: Sulfatase; cl17466 688270006151 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 688270006152 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 688270006153 VPS10 domain; Region: VPS10; smart00602 688270006154 VPS10 domain; Region: VPS10; smart00602 688270006155 VPS10 domain; Region: VPS10; smart00602 688270006156 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 688270006157 Sulfatase; Region: Sulfatase; pfam00884 688270006158 potential frameshift: common BLAST hit: gi|294053999|ref|YP_003547657.1| sulfatase 688270006159 Sulfatase; Region: Sulfatase; cl17466 688270006160 Sulfatase; Region: Sulfatase; cl17466 688270006161 Family description; Region: VCBS; pfam13517 688270006162 Family description; Region: VCBS; pfam13517 688270006163 Family description; Region: VCBS; pfam13517 688270006164 Family description; Region: VCBS; pfam13517 688270006165 Family description; Region: VCBS; pfam13517 688270006166 Family description; Region: VCBS; pfam13517 688270006167 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 688270006168 Family description; Region: VCBS; pfam13517 688270006169 Family description; Region: VCBS; pfam13517 688270006170 Family description; Region: VCBS; pfam13517 688270006171 Family description; Region: VCBS; pfam13517 688270006172 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 688270006173 starch binding outer membrane protein SusD; Region: SusD; cl17845 688270006174 SusD family; Region: SusD; pfam07980 688270006175 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270006176 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270006177 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270006178 Sulfatase; Region: Sulfatase; cl17466 688270006179 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 688270006180 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 688270006181 classical (c) SDRs; Region: SDR_c; cd05233 688270006182 NAD(P) binding site [chemical binding]; other site 688270006183 active site 688270006184 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 688270006185 Domain of unknown function (DUF336); Region: DUF336; pfam03928 688270006186 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 688270006187 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 688270006188 ligand binding site [chemical binding]; other site 688270006189 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 688270006190 Sulfatase; Region: Sulfatase; pfam00884 688270006191 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 688270006192 Sulfatase; Region: Sulfatase; cl17466 688270006193 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 688270006194 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 688270006195 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 688270006196 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 688270006197 Sulfatase; Region: Sulfatase; pfam00884 688270006198 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 688270006199 Sulfatase; Region: Sulfatase; pfam00884 688270006200 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 688270006201 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 688270006202 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 688270006203 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 688270006204 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 688270006205 Sulfatase; Region: Sulfatase; cl17466 688270006206 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 688270006207 Sulfatase; Region: Sulfatase; cl17466 688270006208 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 688270006209 Two component regulator propeller; Region: Reg_prop; pfam07494 688270006210 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 688270006211 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270006212 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270006213 dimer interface [polypeptide binding]; other site 688270006214 phosphorylation site [posttranslational modification] 688270006215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270006216 ATP binding site [chemical binding]; other site 688270006217 Mg2+ binding site [ion binding]; other site 688270006218 G-X-G motif; other site 688270006219 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 688270006220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270006221 active site 688270006222 phosphorylation site [posttranslational modification] 688270006223 intermolecular recognition site; other site 688270006224 dimerization interface [polypeptide binding]; other site 688270006225 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 688270006226 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 688270006227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 688270006228 D-galactonate transporter; Region: 2A0114; TIGR00893 688270006229 putative substrate translocation pore; other site 688270006230 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 688270006231 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 688270006232 active site pocket [active] 688270006233 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 688270006234 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 688270006235 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 688270006236 putative NAD(P) binding site [chemical binding]; other site 688270006237 catalytic Zn binding site [ion binding]; other site 688270006238 structural Zn binding site [ion binding]; other site 688270006239 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 688270006240 galactarate dehydratase; Region: galactar-dH20; TIGR03248 688270006241 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 688270006242 altronate oxidoreductase; Provisional; Region: PRK03643 688270006243 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 688270006244 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 688270006245 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 688270006246 Amidohydrolase; Region: Amidohydro_2; pfam04909 688270006247 short chain dehydrogenase; Provisional; Region: PRK08628 688270006248 classical (c) SDRs; Region: SDR_c; cd05233 688270006249 NAD(P) binding site [chemical binding]; other site 688270006250 active site 688270006251 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 688270006252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 688270006253 putative substrate translocation pore; other site 688270006254 Domain of unknown function (DUF718); Region: DUF718; pfam05336 688270006255 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 688270006256 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 688270006257 active site 688270006258 catalytic residues [active] 688270006259 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 688270006260 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 688270006261 active site pocket [active] 688270006262 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 688270006263 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 688270006264 NAD binding site [chemical binding]; other site 688270006265 catalytic residues [active] 688270006266 substrate binding site [chemical binding]; other site 688270006267 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 688270006268 Sulfatase; Region: Sulfatase; pfam00884 688270006269 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 688270006270 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 688270006271 NADP binding site [chemical binding]; other site 688270006272 homodimer interface [polypeptide binding]; other site 688270006273 active site 688270006274 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 688270006275 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 688270006276 NAD(P) binding site [chemical binding]; other site 688270006277 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 688270006278 Transcriptional regulator [Transcription]; Region: IclR; COG1414 688270006279 Bacterial transcriptional regulator; Region: IclR; pfam01614 688270006280 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 688270006281 active site 688270006282 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 688270006283 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 688270006284 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 688270006285 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 688270006286 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270006287 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270006288 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 688270006289 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270006290 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 688270006291 starch binding outer membrane protein SusD; Region: SusD; cd08977 688270006292 SusD family; Region: SusD; pfam07980 688270006293 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 688270006294 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270006295 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270006296 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 688270006297 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270006298 starch binding outer membrane protein SusD; Region: SusD; cd08977 688270006299 SusE outer membrane protein; Region: SusE; pfam14292 688270006300 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956 688270006301 starch binding site [chemical binding]; other site 688270006302 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956 688270006303 starch binding site [chemical binding]; other site 688270006304 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956 688270006305 starch binding site [chemical binding]; other site 688270006306 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 688270006307 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 688270006308 active site 688270006309 catalytic site [active] 688270006310 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 688270006311 Helix-turn-helix domain; Region: HTH_18; pfam12833 688270006312 Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087 688270006313 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340 688270006314 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 688270006315 Ca binding site [ion binding]; other site 688270006316 active site 688270006317 homodimer interface [polypeptide binding]; other site 688270006318 catalytic site [active] 688270006319 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 688270006320 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 688270006321 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 688270006322 ADP binding site [chemical binding]; other site 688270006323 magnesium binding site [ion binding]; other site 688270006324 putative shikimate binding site; other site 688270006325 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 688270006326 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 688270006327 active site 688270006328 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 688270006329 RNA binding surface [nucleotide binding]; other site 688270006330 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 688270006331 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 688270006332 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 688270006333 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 688270006334 Predicted permeases [General function prediction only]; Region: COG0795 688270006335 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 688270006336 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 688270006337 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 688270006338 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 688270006339 replicative DNA helicase; Region: DnaB; TIGR00665 688270006340 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 688270006341 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 688270006342 Walker A motif; other site 688270006343 ATP binding site [chemical binding]; other site 688270006344 Walker B motif; other site 688270006345 DNA binding loops [nucleotide binding] 688270006346 DTW domain; Region: DTW; cl01221 688270006347 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 688270006348 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 688270006349 putative active site [active] 688270006350 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 688270006351 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 688270006352 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 688270006353 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 688270006354 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 688270006355 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 688270006356 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270006357 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 688270006358 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 688270006359 N-terminal plug; other site 688270006360 ligand-binding site [chemical binding]; other site 688270006361 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 688270006362 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 688270006363 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 688270006364 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 688270006365 dimerization interface [polypeptide binding]; other site 688270006366 CHAP domain; Region: CHAP; pfam05257 688270006367 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 688270006368 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 688270006369 motif II; other site 688270006370 Major royal jelly protein; Region: MRJP; pfam03022 688270006371 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 688270006372 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 688270006373 catalytic residues [active] 688270006374 EthD domain; Region: EthD; cl17553 688270006375 short chain dehydrogenase; Validated; Region: PRK08264 688270006376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270006377 NAD(P) binding site [chemical binding]; other site 688270006378 active site 688270006379 Uncharacterized conserved protein [Function unknown]; Region: COG2128 688270006380 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 688270006381 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 688270006382 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 688270006383 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 688270006384 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 688270006385 active site 688270006386 motif I; other site 688270006387 motif II; other site 688270006388 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 688270006389 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 688270006390 Tic20-like protein; Region: Tic20; pfam09685 688270006391 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 688270006392 23S rRNA binding site [nucleotide binding]; other site 688270006393 L21 binding site [polypeptide binding]; other site 688270006394 L13 binding site [polypeptide binding]; other site 688270006395 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 688270006396 translation initiation factor IF-3; Region: infC; TIGR00168 688270006397 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 688270006398 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 688270006399 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 688270006400 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 688270006401 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 688270006402 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 688270006403 active site 688270006404 dimer interface [polypeptide binding]; other site 688270006405 motif 1; other site 688270006406 motif 2; other site 688270006407 motif 3; other site 688270006408 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 688270006409 anticodon binding site; other site 688270006410 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 688270006411 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 688270006412 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 688270006413 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 688270006414 Walker A/P-loop; other site 688270006415 ATP binding site [chemical binding]; other site 688270006416 Q-loop/lid; other site 688270006417 ABC transporter signature motif; other site 688270006418 Walker B; other site 688270006419 D-loop; other site 688270006420 H-loop/switch region; other site 688270006421 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 688270006422 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 688270006423 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 688270006424 TM-ABC transporter signature motif; other site 688270006425 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 688270006426 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 688270006427 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 688270006428 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 688270006429 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 688270006430 putative substrate binding site [chemical binding]; other site 688270006431 putative ATP binding site [chemical binding]; other site 688270006432 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 688270006433 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 688270006434 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 688270006435 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 688270006436 Haemolysin-III related; Region: HlyIII; cl03831 688270006437 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 688270006438 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 688270006439 ZIP Zinc transporter; Region: Zip; pfam02535 688270006440 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 688270006441 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 688270006442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 688270006443 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 688270006444 TRAM domain; Region: TRAM; pfam01938 688270006445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 688270006446 S-adenosylmethionine binding site [chemical binding]; other site 688270006447 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 688270006448 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 688270006449 inhibitor-cofactor binding pocket; inhibition site 688270006450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270006451 catalytic residue [active] 688270006452 Interferon-induced transmembrane protein; Region: CD225; pfam04505 688270006453 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 688270006454 Smr domain; Region: Smr; cl02619 688270006455 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 688270006456 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 688270006457 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 688270006458 catalytic residue [active] 688270006459 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 688270006460 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270006461 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 688270006462 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270006463 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 688270006464 Peptidase family M23; Region: Peptidase_M23; pfam01551 688270006465 Cell division protein ZapA; Region: ZapA; pfam05164 688270006466 phosphodiesterase; Provisional; Region: PRK12704 688270006467 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 688270006468 Zn2+ binding site [ion binding]; other site 688270006469 Mg2+ binding site [ion binding]; other site 688270006470 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 688270006471 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 688270006472 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 688270006473 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 688270006474 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 688270006475 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 688270006476 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 688270006477 putative active site [active] 688270006478 Zn binding site [ion binding]; other site 688270006479 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 688270006480 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 688270006481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 688270006482 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 688270006483 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 688270006484 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 688270006485 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 688270006486 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 688270006487 catalytic residue [active] 688270006488 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 688270006489 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 688270006490 GMP synthase; Reviewed; Region: guaA; PRK00074 688270006491 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 688270006492 AMP/PPi binding site [chemical binding]; other site 688270006493 candidate oxyanion hole; other site 688270006494 catalytic triad [active] 688270006495 potential glutamine specificity residues [chemical binding]; other site 688270006496 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 688270006497 ATP Binding subdomain [chemical binding]; other site 688270006498 Ligand Binding sites [chemical binding]; other site 688270006499 Dimerization subdomain; other site 688270006500 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 688270006501 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 688270006502 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 688270006503 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 688270006504 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 688270006505 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 688270006506 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 688270006507 ligand binding site [chemical binding]; other site 688270006508 OsmC-like protein; Region: OsmC; pfam02566 688270006509 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 688270006510 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 688270006511 CTP synthetase; Validated; Region: pyrG; PRK05380 688270006512 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 688270006513 Catalytic site [active] 688270006514 active site 688270006515 UTP binding site [chemical binding]; other site 688270006516 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 688270006517 active site 688270006518 putative oxyanion hole; other site 688270006519 catalytic triad [active] 688270006520 membrane protein insertase; Provisional; Region: PRK01318 688270006521 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 688270006522 Fasciclin domain; Region: Fasciclin; pfam02469 688270006523 Fasciclin domain; Region: Fasciclin; pfam02469 688270006524 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 688270006525 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 688270006526 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 688270006527 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 688270006528 FMN binding site [chemical binding]; other site 688270006529 substrate binding site [chemical binding]; other site 688270006530 putative catalytic residue [active] 688270006531 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 688270006532 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 688270006533 homodimer interface [polypeptide binding]; other site 688270006534 metal binding site [ion binding]; metal-binding site 688270006535 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 688270006536 homodimer interface [polypeptide binding]; other site 688270006537 active site 688270006538 putative chemical substrate binding site [chemical binding]; other site 688270006539 metal binding site [ion binding]; metal-binding site 688270006540 multidrug efflux protein; Reviewed; Region: PRK01766 688270006541 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 688270006542 cation binding site [ion binding]; other site 688270006543 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 688270006544 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 688270006545 active site 688270006546 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 688270006547 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 688270006548 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 688270006549 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 688270006550 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 688270006551 Ligand binding site; other site 688270006552 Putative Catalytic site; other site 688270006553 DXD motif; other site 688270006554 membrane ATPase/protein kinase; Provisional; Region: PRK09435 688270006555 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 688270006556 Walker A; other site 688270006557 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 688270006558 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 688270006559 active site 688270006560 catalytic residues [active] 688270006561 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 688270006562 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 688270006563 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270006564 DNA binding residues [nucleotide binding] 688270006565 methionine sulfoxide reductase A; Provisional; Region: PRK14054 688270006566 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 688270006567 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 688270006568 Peptidase family M23; Region: Peptidase_M23; pfam01551 688270006569 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 688270006570 Histidine kinase; Region: HisKA_2; pfam07568 688270006571 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 688270006572 ATP binding site [chemical binding]; other site 688270006573 Mg2+ binding site [ion binding]; other site 688270006574 G-X-G motif; other site 688270006575 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 688270006576 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 688270006577 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 688270006578 nucleotide binding region [chemical binding]; other site 688270006579 ATP-binding site [chemical binding]; other site 688270006580 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 688270006581 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 688270006582 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 688270006583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 688270006584 Walker A/P-loop; other site 688270006585 ATP binding site [chemical binding]; other site 688270006586 Q-loop/lid; other site 688270006587 ABC transporter signature motif; other site 688270006588 Walker B; other site 688270006589 D-loop; other site 688270006590 H-loop/switch region; other site 688270006591 ABC transporter; Region: ABC_tran_2; pfam12848 688270006592 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 688270006593 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 688270006594 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 688270006595 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 688270006596 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 688270006597 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 688270006598 Walker A/P-loop; other site 688270006599 ATP binding site [chemical binding]; other site 688270006600 Q-loop/lid; other site 688270006601 ABC transporter signature motif; other site 688270006602 Walker B; other site 688270006603 D-loop; other site 688270006604 H-loop/switch region; other site 688270006605 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 688270006606 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 688270006607 KpsF/GutQ family protein; Region: kpsF; TIGR00393 688270006608 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 688270006609 putative active site [active] 688270006610 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 688270006611 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 688270006612 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 688270006613 ATP binding site [chemical binding]; other site 688270006614 putative Mg++ binding site [ion binding]; other site 688270006615 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 688270006616 nucleotide binding region [chemical binding]; other site 688270006617 ATP-binding site [chemical binding]; other site 688270006618 RQC domain; Region: RQC; pfam09382 688270006619 HRDC domain; Region: HRDC; pfam00570 688270006620 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 688270006621 thiS-thiF/thiG interaction site; other site 688270006622 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 688270006623 ThiC-associated domain; Region: ThiC-associated; pfam13667 688270006624 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 688270006625 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 688270006626 thiamine phosphate binding site [chemical binding]; other site 688270006627 active site 688270006628 pyrophosphate binding site [ion binding]; other site 688270006629 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 688270006630 thiamine phosphate binding site [chemical binding]; other site 688270006631 active site 688270006632 pyrophosphate binding site [ion binding]; other site 688270006633 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 688270006634 ThiS interaction site; other site 688270006635 putative active site [active] 688270006636 tetramer interface [polypeptide binding]; other site 688270006637 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 688270006638 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 688270006639 FeS/SAM binding site; other site 688270006640 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 688270006641 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 688270006642 dimer interface [polypeptide binding]; other site 688270006643 catalytic triad [active] 688270006644 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 688270006645 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 688270006646 active site 688270006647 catalytic tetrad [active] 688270006648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 688270006649 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270006650 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 688270006651 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270006652 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 688270006653 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 688270006654 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 688270006655 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 688270006656 TLC ATP/ADP transporter; Region: TLC; cl03940 688270006657 HEAT repeats; Region: HEAT_2; pfam13646 688270006658 short chain dehydrogenase; Provisional; Region: PRK12939 688270006659 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 688270006660 NADP binding site [chemical binding]; other site 688270006661 homodimer interface [polypeptide binding]; other site 688270006662 active site 688270006663 substrate binding site [chemical binding]; other site 688270006664 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 688270006665 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 688270006666 motif II; other site 688270006667 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 688270006668 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 688270006669 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 688270006670 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 688270006671 Uncharacterized conserved protein [Function unknown]; Region: COG1262 688270006672 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 688270006673 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 688270006674 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 688270006675 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 688270006676 Transposase domain (DUF772); Region: DUF772; pfam05598 688270006677 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 688270006678 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 688270006679 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270006680 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270006681 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 688270006682 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270006683 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 688270006684 starch binding outer membrane protein SusD; Region: SusD; cl17845 688270006685 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 688270006686 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 688270006687 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 688270006688 catalytic residue [active] 688270006689 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 688270006690 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 688270006691 active site 688270006692 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 688270006693 PspC domain; Region: PspC; pfam04024 688270006694 Predicted transcriptional regulators [Transcription]; Region: COG1695 688270006695 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 688270006696 Tic20-like protein; Region: Tic20; pfam09685 688270006697 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 688270006698 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 688270006699 dimer interface [polypeptide binding]; other site 688270006700 ADP-ribose binding site [chemical binding]; other site 688270006701 active site 688270006702 nudix motif; other site 688270006703 metal binding site [ion binding]; metal-binding site 688270006704 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 688270006705 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 688270006706 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 688270006707 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 688270006708 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 688270006709 dimerization interface [polypeptide binding]; other site 688270006710 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 688270006711 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 688270006712 dimerization interface [polypeptide binding]; other site 688270006713 DPS ferroxidase diiron center [ion binding]; other site 688270006714 ion pore; other site 688270006715 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 688270006716 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 688270006717 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 688270006718 GAF domain; Region: GAF; pfam01590 688270006719 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270006720 dimer interface [polypeptide binding]; other site 688270006721 phosphorylation site [posttranslational modification] 688270006722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270006723 ATP binding site [chemical binding]; other site 688270006724 Mg2+ binding site [ion binding]; other site 688270006725 G-X-G motif; other site 688270006726 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270006727 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 688270006728 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 688270006729 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 688270006730 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 688270006731 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 688270006732 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 688270006733 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 688270006734 shikimate binding site; other site 688270006735 NAD(P) binding site [chemical binding]; other site 688270006736 Domain of unknown function (DUF368); Region: DUF368; pfam04018 688270006737 Domain of unknown function (DUF368); Region: DUF368; pfam04018 688270006738 TPR repeat; Region: TPR_11; pfam13414 688270006739 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270006740 binding surface 688270006741 TPR motif; other site 688270006742 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270006743 binding surface 688270006744 TPR motif; other site 688270006745 TPR repeat; Region: TPR_11; pfam13414 688270006746 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270006747 binding surface 688270006748 TPR repeat; Region: TPR_11; pfam13414 688270006749 TPR motif; other site 688270006750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270006751 binding surface 688270006752 TPR motif; other site 688270006753 TPR repeat; Region: TPR_11; pfam13414 688270006754 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 688270006755 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 688270006756 inhibitor-cofactor binding pocket; inhibition site 688270006757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270006758 catalytic residue [active] 688270006759 OstA-like protein; Region: OstA_2; pfam13100 688270006760 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 688270006761 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 688270006762 GDP-binding site [chemical binding]; other site 688270006763 ACT binding site; other site 688270006764 IMP binding site; other site 688270006765 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 688270006766 metal binding site 2 [ion binding]; metal-binding site 688270006767 putative DNA binding helix; other site 688270006768 metal binding site 1 [ion binding]; metal-binding site 688270006769 dimer interface [polypeptide binding]; other site 688270006770 structural Zn2+ binding site [ion binding]; other site 688270006771 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 688270006772 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 688270006773 Zn2+ binding site [ion binding]; other site 688270006774 Mg2+ binding site [ion binding]; other site 688270006775 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 688270006776 synthetase active site [active] 688270006777 NTP binding site [chemical binding]; other site 688270006778 metal binding site [ion binding]; metal-binding site 688270006779 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 688270006780 ACT domain; Region: ACT_4; pfam13291 688270006781 Peptidase family M48; Region: Peptidase_M48; pfam01435 688270006782 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 688270006783 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 688270006784 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 688270006785 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 688270006786 MoaE interaction surface [polypeptide binding]; other site 688270006787 MoeB interaction surface [polypeptide binding]; other site 688270006788 thiocarboxylated glycine; other site 688270006789 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 688270006790 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 688270006791 FeS/SAM binding site; other site 688270006792 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 688270006793 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 688270006794 trimer interface [polypeptide binding]; other site 688270006795 dimer interface [polypeptide binding]; other site 688270006796 putative active site [active] 688270006797 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 688270006798 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 688270006799 GTP binding site; other site 688270006800 hypothetical protein; Validated; Region: PRK07411 688270006801 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 688270006802 ATP binding site [chemical binding]; other site 688270006803 substrate interface [chemical binding]; other site 688270006804 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 688270006805 active site residue [active] 688270006806 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 688270006807 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 688270006808 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 688270006809 dimer interface [polypeptide binding]; other site 688270006810 putative functional site; other site 688270006811 putative MPT binding site; other site 688270006812 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 688270006813 Amidohydrolase; Region: Amidohydro_4; pfam13147 688270006814 active site 688270006815 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 688270006816 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 688270006817 active site 688270006818 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 688270006819 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 688270006820 active site 688270006821 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 688270006822 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 688270006823 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 688270006824 metal binding site [ion binding]; metal-binding site 688270006825 dimer interface [polypeptide binding]; other site 688270006826 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 688270006827 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 688270006828 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 688270006829 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 688270006830 active site 688270006831 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 688270006832 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 688270006833 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 688270006834 DHH family; Region: DHH; pfam01368 688270006835 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 688270006836 putative active site [active] 688270006837 putative metal binding site [ion binding]; other site 688270006838 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 688270006839 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 688270006840 active site 688270006841 multimer interface [polypeptide binding]; other site 688270006842 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 688270006843 PLD-like domain; Region: PLDc_2; pfam13091 688270006844 putative homodimer interface [polypeptide binding]; other site 688270006845 putative active site [active] 688270006846 catalytic site [active] 688270006847 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 688270006848 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 688270006849 ATP binding site [chemical binding]; other site 688270006850 putative Mg++ binding site [ion binding]; other site 688270006851 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 688270006852 nucleotide binding region [chemical binding]; other site 688270006853 ATP-binding site [chemical binding]; other site 688270006854 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 688270006855 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 688270006856 Catalytic site [active] 688270006857 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 688270006858 active site 688270006859 8-oxo-dGMP binding site [chemical binding]; other site 688270006860 nudix motif; other site 688270006861 metal binding site [ion binding]; metal-binding site 688270006862 Protein of unknown function (DUF721); Region: DUF721; pfam05258 688270006863 recombination protein F; Reviewed; Region: recF; PRK00064 688270006864 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 688270006865 Walker A/P-loop; other site 688270006866 ATP binding site [chemical binding]; other site 688270006867 Q-loop/lid; other site 688270006868 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 688270006869 ABC transporter signature motif; other site 688270006870 Walker B; other site 688270006871 D-loop; other site 688270006872 H-loop/switch region; other site 688270006873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270006874 binding surface 688270006875 Tetratricopeptide repeat; Region: TPR_16; pfam13432 688270006876 TPR motif; other site 688270006877 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270006878 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 688270006879 homopentamer interface [polypeptide binding]; other site 688270006880 active site 688270006881 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 688270006882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270006883 ATP binding site [chemical binding]; other site 688270006884 Mg2+ binding site [ion binding]; other site 688270006885 G-X-G motif; other site 688270006886 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 688270006887 ATP binding site [chemical binding]; other site 688270006888 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 688270006889 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 688270006890 Rhomboid family; Region: Rhomboid; pfam01694 688270006891 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 688270006892 putative catalytic site [active] 688270006893 putative metal binding site [ion binding]; other site 688270006894 putative phosphate binding site [ion binding]; other site 688270006895 WbqC-like protein family; Region: WbqC; pfam08889 688270006896 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 688270006897 Catalytic site [active] 688270006898 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 688270006899 dihydrodipicolinate reductase; Provisional; Region: PRK00048 688270006900 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 688270006901 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 688270006902 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 688270006903 ParB-like nuclease domain; Region: ParBc; pfam02195 688270006904 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 688270006905 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 688270006906 P-loop; other site 688270006907 Magnesium ion binding site [ion binding]; other site 688270006908 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 688270006909 Magnesium ion binding site [ion binding]; other site 688270006910 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 688270006911 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 688270006912 active site 688270006913 substrate binding site [chemical binding]; other site 688270006914 coenzyme B12 binding site [chemical binding]; other site 688270006915 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 688270006916 B12 binding site [chemical binding]; other site 688270006917 cobalt ligand [ion binding]; other site 688270006918 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 688270006919 heterodimer interface [polypeptide binding]; other site 688270006920 substrate interaction site [chemical binding]; other site 688270006921 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 688270006922 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 688270006923 ATP-binding site [chemical binding]; other site 688270006924 Sugar specificity; other site 688270006925 Pyrimidine base specificity; other site 688270006926 Major Facilitator Superfamily; Region: MFS_1; pfam07690 688270006927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 688270006928 putative substrate translocation pore; other site 688270006929 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 688270006930 acetyl-CoA synthetase; Provisional; Region: PRK00174 688270006931 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 688270006932 active site 688270006933 CoA binding site [chemical binding]; other site 688270006934 acyl-activating enzyme (AAE) consensus motif; other site 688270006935 AMP binding site [chemical binding]; other site 688270006936 acetate binding site [chemical binding]; other site 688270006937 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 688270006938 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 688270006939 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 688270006940 muropeptide transporter; Reviewed; Region: ampG; PRK11902 688270006941 muropeptide transporter; Validated; Region: ampG; cl17669 688270006942 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 688270006943 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 688270006944 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 688270006945 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 688270006946 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 688270006947 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 688270006948 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 688270006949 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 688270006950 putative active site [active] 688270006951 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 688270006952 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 688270006953 Transposase; Region: DDE_Tnp_ISL3; pfam01610 688270006954 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 688270006955 putative metal binding site; other site 688270006956 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 688270006957 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 688270006958 Substrate binding site; other site 688270006959 metal-binding site 688270006960 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 688270006961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 688270006962 Walker A motif; other site 688270006963 ATP binding site [chemical binding]; other site 688270006964 Walker B motif; other site 688270006965 arginine finger; other site 688270006966 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 688270006967 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 688270006968 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 688270006969 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 688270006970 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 688270006971 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 688270006972 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 688270006973 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 688270006974 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 688270006975 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 688270006976 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 688270006977 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 688270006978 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 688270006979 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 688270006980 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 688270006981 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 688270006982 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 688270006983 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 688270006984 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 688270006985 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 688270006986 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 688270006987 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 688270006988 ligand binding site [chemical binding]; other site 688270006989 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 688270006990 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270006991 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 688270006992 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 688270006993 N-terminal plug; other site 688270006994 ligand-binding site [chemical binding]; other site 688270006995 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 688270006996 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 688270006997 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 688270006998 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 688270006999 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 688270007000 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 688270007001 active site 688270007002 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 688270007003 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 688270007004 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 688270007005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270007006 active site 688270007007 phosphorylation site [posttranslational modification] 688270007008 intermolecular recognition site; other site 688270007009 dimerization interface [polypeptide binding]; other site 688270007010 Protein of unknown function (DUF808); Region: DUF808; cl01002 688270007011 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 688270007012 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 688270007013 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 688270007014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270007015 NAD(P) binding site [chemical binding]; other site 688270007016 active site 688270007017 VanW like protein; Region: VanW; pfam04294 688270007018 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 688270007019 active site 688270007020 catalytic triad [active] 688270007021 oxyanion hole [active] 688270007022 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 688270007023 Leucine-rich repeats; other site 688270007024 Leucine rich repeat; Region: LRR_8; pfam13855 688270007025 Substrate binding site [chemical binding]; other site 688270007026 Leucine rich repeat; Region: LRR_8; pfam13855 688270007027 Leucine rich repeat; Region: LRR_8; pfam13855 688270007028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 688270007029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 688270007030 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 688270007031 Protein of unknown function DUF58; Region: DUF58; pfam01882 688270007032 MoxR-like ATPases [General function prediction only]; Region: COG0714 688270007033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 688270007034 Walker A motif; other site 688270007035 ATP binding site [chemical binding]; other site 688270007036 Walker B motif; other site 688270007037 arginine finger; other site 688270007038 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 688270007039 Integral membrane protein DUF95; Region: DUF95; pfam01944 688270007040 RDD family; Region: RDD; pfam06271 688270007041 Predicted membrane protein [Function unknown]; Region: COG2860 688270007042 UPF0126 domain; Region: UPF0126; pfam03458 688270007043 UPF0126 domain; Region: UPF0126; pfam03458 688270007044 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 688270007045 active site 688270007046 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 688270007047 putative active site [active] 688270007048 putative CoA binding site [chemical binding]; other site 688270007049 nudix motif; other site 688270007050 metal binding site [ion binding]; metal-binding site 688270007051 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 688270007052 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 688270007053 putative acyl-acceptor binding pocket; other site 688270007054 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 688270007055 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 688270007056 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 688270007057 DNA binding residues [nucleotide binding] 688270007058 Transposase IS200 like; Region: Y1_Tnp; pfam01797 688270007059 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 688270007060 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 688270007061 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 688270007062 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 688270007063 active site 688270007064 Int/Topo IB signature motif; other site 688270007065 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 688270007066 Dehydroquinase class II; Region: DHquinase_II; pfam01220 688270007067 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 688270007068 active site 688270007069 trimer interface [polypeptide binding]; other site 688270007070 dimer interface [polypeptide binding]; other site 688270007071 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 688270007072 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 688270007073 integral membrane protein; Region: integ_memb_HG; TIGR03954 688270007074 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 688270007075 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 688270007076 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 688270007077 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 688270007078 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 688270007079 SelR domain; Region: SelR; pfam01641 688270007080 glycogen branching enzyme; Provisional; Region: PRK12313 688270007081 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 688270007082 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 688270007083 active site 688270007084 catalytic site [active] 688270007085 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 688270007086 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 688270007087 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 688270007088 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 688270007089 trimer interface [polypeptide binding]; other site 688270007090 active site 688270007091 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 688270007092 catalytic site [active] 688270007093 Peptidase family M48; Region: Peptidase_M48; pfam01435 688270007094 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 688270007095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 688270007096 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 688270007097 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 688270007098 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 688270007099 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270007100 DNA binding residues [nucleotide binding] 688270007101 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 688270007102 Found in ATP-dependent protease La (LON); Region: LON; smart00464 688270007103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 688270007104 Walker A motif; other site 688270007105 ATP binding site [chemical binding]; other site 688270007106 Walker B motif; other site 688270007107 arginine finger; other site 688270007108 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 688270007109 cytidylate kinase; Provisional; Region: cmk; PRK00023 688270007110 AAA domain; Region: AAA_17; pfam13207 688270007111 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 688270007112 CMP-binding site; other site 688270007113 The sites determining sugar specificity; other site 688270007114 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 688270007115 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 688270007116 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 688270007117 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 688270007118 RNA binding site [nucleotide binding]; other site 688270007119 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 688270007120 RNA binding site [nucleotide binding]; other site 688270007121 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 688270007122 RNA binding site [nucleotide binding]; other site 688270007123 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 688270007124 RNA binding site [nucleotide binding]; other site 688270007125 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 688270007126 RNA binding site [nucleotide binding]; other site 688270007127 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 688270007128 RNA binding site [nucleotide binding]; other site 688270007129 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 688270007130 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 688270007131 active site 688270007132 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 688270007133 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 688270007134 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 688270007135 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 688270007136 ribonuclease Z; Reviewed; Region: PRK00055 688270007137 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 688270007138 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 688270007139 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 688270007140 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 688270007141 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 688270007142 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 688270007143 catalytic core [active] 688270007144 polyphosphate kinase; Provisional; Region: PRK05443 688270007145 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 688270007146 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 688270007147 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 688270007148 domain interface [polypeptide binding]; other site 688270007149 active site 688270007150 catalytic site [active] 688270007151 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 688270007152 domain interface [polypeptide binding]; other site 688270007153 active site 688270007154 catalytic site [active] 688270007155 exopolyphosphatase; Region: exo_poly_only; TIGR03706 688270007156 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 688270007157 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 688270007158 active site 688270007159 dinuclear metal binding site [ion binding]; other site 688270007160 dimerization interface [polypeptide binding]; other site 688270007161 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 688270007162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 688270007163 Walker A motif; other site 688270007164 ATP binding site [chemical binding]; other site 688270007165 Walker B motif; other site 688270007166 arginine finger; other site 688270007167 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 688270007168 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 688270007169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 688270007170 S-adenosylmethionine binding site [chemical binding]; other site 688270007171 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 688270007172 AAA domain; Region: AAA_30; pfam13604 688270007173 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 688270007174 Family description; Region: UvrD_C_2; pfam13538 688270007175 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 688270007176 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 688270007177 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 688270007178 Ligand binding site; other site 688270007179 oligomer interface; other site 688270007180 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 688270007181 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 688270007182 Chloramphenicol acetyltransferase; Region: CAT; cl02008 688270007183 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 688270007184 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 688270007185 active site 688270007186 NAD binding site [chemical binding]; other site 688270007187 metal binding site [ion binding]; metal-binding site 688270007188 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 688270007189 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 688270007190 putative acyl-acceptor binding pocket; other site 688270007191 hypothetical protein; Provisional; Region: PRK12378 688270007192 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 688270007193 aromatic arch; other site 688270007194 DCoH dimer interaction site [polypeptide binding]; other site 688270007195 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 688270007196 DCoH tetramer interaction site [polypeptide binding]; other site 688270007197 substrate binding site [chemical binding]; other site 688270007198 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 688270007199 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270007200 NAD(P) binding site [chemical binding]; other site 688270007201 active site 688270007202 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 688270007203 glutaminase; Provisional; Region: PRK00971 688270007204 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 688270007205 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 688270007206 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 688270007207 Ca binding site [ion binding]; other site 688270007208 ligand binding site I [chemical binding]; other site 688270007209 homodimer interface [polypeptide binding]; other site 688270007210 ligand binding site II [chemical binding]; other site 688270007211 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 688270007212 Alginate lyase; Region: Alginate_lyase2; pfam08787 688270007213 Alginate lyase; Region: Alginate_lyase2; pfam08787 688270007214 threonine synthase; Validated; Region: PRK09225 688270007215 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 688270007216 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 688270007217 catalytic residue [active] 688270007218 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 688270007219 homoserine kinase; Provisional; Region: PRK01212 688270007220 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 688270007221 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 688270007222 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 688270007223 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 688270007224 putative catalytic residues [active] 688270007225 nucleotide binding site [chemical binding]; other site 688270007226 aspartate binding site [chemical binding]; other site 688270007227 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 688270007228 dimer interface [polypeptide binding]; other site 688270007229 putative threonine allosteric regulatory site; other site 688270007230 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 688270007231 putative threonine allosteric regulatory site; other site 688270007232 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 688270007233 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 688270007234 putative carbohydrate kinase; Provisional; Region: PRK10565 688270007235 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 688270007236 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 688270007237 putative substrate binding site [chemical binding]; other site 688270007238 putative ATP binding site [chemical binding]; other site 688270007239 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 688270007240 Clp amino terminal domain; Region: Clp_N; pfam02861 688270007241 Clp amino terminal domain; Region: Clp_N; pfam02861 688270007242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 688270007243 Walker A motif; other site 688270007244 ATP binding site [chemical binding]; other site 688270007245 Walker B motif; other site 688270007246 arginine finger; other site 688270007247 UvrB/uvrC motif; Region: UVR; pfam02151 688270007248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 688270007249 Walker A motif; other site 688270007250 ATP binding site [chemical binding]; other site 688270007251 Walker B motif; other site 688270007252 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 688270007253 DNA gyrase subunit A; Validated; Region: PRK05560 688270007254 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 688270007255 CAP-like domain; other site 688270007256 active site 688270007257 primary dimer interface [polypeptide binding]; other site 688270007258 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 688270007259 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 688270007260 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 688270007261 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 688270007262 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 688270007263 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 688270007264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270007265 binding surface 688270007266 TPR motif; other site 688270007267 TPR repeat; Region: TPR_11; pfam13414 688270007268 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 688270007269 Integrase core domain; Region: rve; pfam00665 688270007270 Integrase core domain; Region: rve_3; pfam13683 688270007271 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 688270007272 NlpC/P60 family; Region: NLPC_P60; pfam00877 688270007273 acetyl-CoA C-acetyltransferase; Region: PLN02644 688270007274 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 688270007275 dimer interface [polypeptide binding]; other site 688270007276 active site 688270007277 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 688270007278 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 688270007279 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 688270007280 Zn2+ binding site [ion binding]; other site 688270007281 Mg2+ binding site [ion binding]; other site 688270007282 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 688270007283 active site 688270007284 domain interfaces; other site 688270007285 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 688270007286 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 688270007287 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 688270007288 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 688270007289 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 688270007290 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 688270007291 motif II; other site 688270007292 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 688270007293 PAS domain S-box; Region: sensory_box; TIGR00229 688270007294 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270007295 putative active site [active] 688270007296 heme pocket [chemical binding]; other site 688270007297 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270007298 PAS fold; Region: PAS_3; pfam08447 688270007299 putative active site [active] 688270007300 heme pocket [chemical binding]; other site 688270007301 PAS fold; Region: PAS_4; pfam08448 688270007302 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270007303 putative active site [active] 688270007304 heme pocket [chemical binding]; other site 688270007305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270007306 PAS domain; Region: PAS_9; pfam13426 688270007307 putative active site [active] 688270007308 heme pocket [chemical binding]; other site 688270007309 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 688270007310 GAF domain; Region: GAF; pfam01590 688270007311 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270007312 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270007313 dimer interface [polypeptide binding]; other site 688270007314 phosphorylation site [posttranslational modification] 688270007315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270007316 ATP binding site [chemical binding]; other site 688270007317 Mg2+ binding site [ion binding]; other site 688270007318 G-X-G motif; other site 688270007319 Response regulator receiver domain; Region: Response_reg; pfam00072 688270007320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270007321 active site 688270007322 phosphorylation site [posttranslational modification] 688270007323 intermolecular recognition site; other site 688270007324 dimerization interface [polypeptide binding]; other site 688270007325 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 688270007326 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 688270007327 ligand binding site [chemical binding]; other site 688270007328 flexible hinge region; other site 688270007329 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 688270007330 non-specific DNA interactions [nucleotide binding]; other site 688270007331 DNA binding site [nucleotide binding] 688270007332 sequence specific DNA binding site [nucleotide binding]; other site 688270007333 putative cAMP binding site [chemical binding]; other site 688270007334 YtxH-like protein; Region: YtxH; pfam12732 688270007335 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 688270007336 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 688270007337 NAD(P) binding site [chemical binding]; other site 688270007338 catalytic residues [active] 688270007339 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 688270007340 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 688270007341 dimerization interface [polypeptide binding]; other site 688270007342 DPS ferroxidase diiron center [ion binding]; other site 688270007343 ion pore; other site 688270007344 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 688270007345 pyruvate dehydrogenase; Provisional; Region: PRK06546 688270007346 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 688270007347 PYR/PP interface [polypeptide binding]; other site 688270007348 dimer interface [polypeptide binding]; other site 688270007349 tetramer interface [polypeptide binding]; other site 688270007350 TPP binding site [chemical binding]; other site 688270007351 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 688270007352 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 688270007353 TPP-binding site [chemical binding]; other site 688270007354 Thioredoxin; Region: Thioredoxin_4; pfam13462 688270007355 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 688270007356 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 688270007357 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 688270007358 myosin-cross-reactive antigen; Provisional; Region: PRK13977 688270007359 myosin-cross-reactive antigen; Provisional; Region: PRK13977 688270007360 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 688270007361 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 688270007362 Ligand Binding Site [chemical binding]; other site 688270007363 glucokinase, proteobacterial type; Region: glk; TIGR00749 688270007364 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 688270007365 nucleotide binding site [chemical binding]; other site 688270007366 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 688270007367 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 688270007368 putative active site; other site 688270007369 catalytic residue [active] 688270007370 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 688270007371 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 688270007372 putative substrate binding site [chemical binding]; other site 688270007373 putative ATP binding site [chemical binding]; other site 688270007374 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 688270007375 catalytic core [active] 688270007376 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 688270007377 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 688270007378 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 688270007379 putative ligand binding site [chemical binding]; other site 688270007380 putative NAD binding site [chemical binding]; other site 688270007381 catalytic site [active] 688270007382 phosphoenolpyruvate synthase; Validated; Region: PRK06464 688270007383 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 688270007384 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 688270007385 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 688270007386 alternate F1F0 ATPase, F1 subunit beta; Region: alt_F1F0_F1_bet; TIGR03305 688270007387 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 688270007388 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 688270007389 alpha subunit interaction interface [polypeptide binding]; other site 688270007390 Walker A motif; other site 688270007391 ATP binding site [chemical binding]; other site 688270007392 Walker B motif; other site 688270007393 inhibitor binding site; inhibition site 688270007394 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 688270007395 F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228 688270007396 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 688270007397 gamma subunit interface [polypeptide binding]; other site 688270007398 epsilon subunit interface [polypeptide binding]; other site 688270007399 LBP interface [polypeptide binding]; other site 688270007400 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 688270007401 F1/F0 ATPase, Methanosarcina type, subunit 2; Region: F1F0_chp_2; TIGR03165 688270007402 ATP synthase A chain; Region: ATP-synt_A; cl00413 688270007403 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 688270007404 alternate F1F0 ATPase, F0 subunit C; Region: alt_F1F0_F0_C; TIGR03322 688270007405 alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321 688270007406 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 688270007407 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 688270007408 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 688270007409 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 688270007410 beta subunit interaction interface [polypeptide binding]; other site 688270007411 Walker A motif; other site 688270007412 ATP binding site [chemical binding]; other site 688270007413 Walker B motif; other site 688270007414 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 688270007415 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 688270007416 core domain interface [polypeptide binding]; other site 688270007417 delta subunit interface [polypeptide binding]; other site 688270007418 epsilon subunit interface [polypeptide binding]; other site 688270007419 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 688270007420 enolase; Provisional; Region: eno; PRK00077 688270007421 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 688270007422 dimer interface [polypeptide binding]; other site 688270007423 metal binding site [ion binding]; metal-binding site 688270007424 substrate binding pocket [chemical binding]; other site 688270007425 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 688270007426 mce related protein; Region: MCE; pfam02470 688270007427 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 688270007428 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 688270007429 Walker A/P-loop; other site 688270007430 ATP binding site [chemical binding]; other site 688270007431 Q-loop/lid; other site 688270007432 ABC transporter signature motif; other site 688270007433 Walker B; other site 688270007434 D-loop; other site 688270007435 H-loop/switch region; other site 688270007436 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 688270007437 Permease; Region: Permease; pfam02405 688270007438 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 688270007439 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 688270007440 Cl- selectivity filter; other site 688270007441 Cl- binding residues [ion binding]; other site 688270007442 pore gating glutamate residue; other site 688270007443 dimer interface [polypeptide binding]; other site 688270007444 H+/Cl- coupling transport residue; other site 688270007445 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 688270007446 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 688270007447 ligand binding site [chemical binding]; other site 688270007448 flexible hinge region; other site 688270007449 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 688270007450 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 688270007451 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 688270007452 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325 688270007453 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 688270007454 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 688270007455 Ligand Binding Site [chemical binding]; other site 688270007456 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 688270007457 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 688270007458 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 688270007459 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 688270007460 Domain interface; other site 688270007461 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 688270007462 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 688270007463 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 688270007464 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 688270007465 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 688270007466 ligand binding site [chemical binding]; other site 688270007467 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 688270007468 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 688270007469 lipoyl attachment site [posttranslational modification]; other site 688270007470 Methyltransferase domain; Region: Methyltransf_31; pfam13847 688270007471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 688270007472 S-adenosylmethionine binding site [chemical binding]; other site 688270007473 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 688270007474 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 688270007475 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 688270007476 catalytic residue [active] 688270007477 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 688270007478 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 688270007479 dimer interface [polypeptide binding]; other site 688270007480 active site 688270007481 putative transporter; Provisional; Region: PRK11660 688270007482 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 688270007483 Sulfate transporter family; Region: Sulfate_transp; pfam00916 688270007484 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 688270007485 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 688270007486 isocitrate dehydrogenase; Validated; Region: PRK07362 688270007487 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 688270007488 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 688270007489 ligand binding site [chemical binding]; other site 688270007490 flexible hinge region; other site 688270007491 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 688270007492 putative switch regulator; other site 688270007493 non-specific DNA interactions [nucleotide binding]; other site 688270007494 DNA binding site [nucleotide binding] 688270007495 sequence specific DNA binding site [nucleotide binding]; other site 688270007496 putative cAMP binding site [chemical binding]; other site 688270007497 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 688270007498 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 688270007499 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 688270007500 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 688270007501 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 688270007502 tetramer interface [polypeptide binding]; other site 688270007503 heme binding pocket [chemical binding]; other site 688270007504 Transcriptional regulator [Transcription]; Region: LysR; COG0583 688270007505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 688270007506 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 688270007507 dimerization interface [polypeptide binding]; other site 688270007508 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 688270007509 putative catalytic residues [active] 688270007510 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 688270007511 Peptidase family M23; Region: Peptidase_M23; pfam01551 688270007512 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 688270007513 Putative esterase; Region: Esterase; pfam00756 688270007514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 688270007515 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 688270007516 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 688270007517 NAD binding site [chemical binding]; other site 688270007518 catalytic Zn binding site [ion binding]; other site 688270007519 substrate binding site [chemical binding]; other site 688270007520 structural Zn binding site [ion binding]; other site 688270007521 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 688270007522 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 688270007523 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 688270007524 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 688270007525 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 688270007526 catalytic loop [active] 688270007527 iron binding site [ion binding]; other site 688270007528 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 688270007529 Cytochrome P450; Region: p450; cl12078 688270007530 Cupin domain; Region: Cupin_2; pfam07883 688270007531 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 688270007532 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 688270007533 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 688270007534 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 688270007535 putative active site [active] 688270007536 catalytic site [active] 688270007537 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 688270007538 putative active site [active] 688270007539 catalytic site [active] 688270007540 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 688270007541 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 688270007542 putative ligand binding site [chemical binding]; other site 688270007543 putative NAD binding site [chemical binding]; other site 688270007544 catalytic site [active] 688270007545 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 688270007546 Mechanosensitive ion channel; Region: MS_channel; pfam00924 688270007547 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 688270007548 Ligand Binding Site [chemical binding]; other site 688270007549 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 688270007550 Ligand Binding Site [chemical binding]; other site 688270007551 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 688270007552 Ligand Binding Site [chemical binding]; other site 688270007553 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 688270007554 Ligand Binding Site [chemical binding]; other site 688270007555 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 688270007556 Ligand Binding Site [chemical binding]; other site 688270007557 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 688270007558 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 688270007559 catalytic residues [active] 688270007560 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 688270007561 Ligand Binding Site [chemical binding]; other site 688270007562 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 688270007563 Ligand Binding Site [chemical binding]; other site 688270007564 Universal stress protein family; Region: Usp; pfam00582 688270007565 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 688270007566 Ligand Binding Site [chemical binding]; other site 688270007567 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 688270007568 Response regulator receiver domain; Region: Response_reg; pfam00072 688270007569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270007570 active site 688270007571 phosphorylation site [posttranslational modification] 688270007572 intermolecular recognition site; other site 688270007573 dimerization interface [polypeptide binding]; other site 688270007574 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 688270007575 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 688270007576 ligand binding site [chemical binding]; other site 688270007577 flexible hinge region; other site 688270007578 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 688270007579 putative switch regulator; other site 688270007580 non-specific DNA interactions [nucleotide binding]; other site 688270007581 DNA binding site [nucleotide binding] 688270007582 sequence specific DNA binding site [nucleotide binding]; other site 688270007583 putative cAMP binding site [chemical binding]; other site 688270007584 PAS domain S-box; Region: sensory_box; TIGR00229 688270007585 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270007586 putative active site [active] 688270007587 heme pocket [chemical binding]; other site 688270007588 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270007589 PAS domain; Region: PAS_9; pfam13426 688270007590 putative active site [active] 688270007591 heme pocket [chemical binding]; other site 688270007592 PAS domain S-box; Region: sensory_box; TIGR00229 688270007593 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270007594 putative active site [active] 688270007595 heme pocket [chemical binding]; other site 688270007596 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270007597 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 688270007598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270007599 ATP binding site [chemical binding]; other site 688270007600 Mg2+ binding site [ion binding]; other site 688270007601 G-X-G motif; other site 688270007602 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 688270007603 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 688270007604 putative substrate binding site [chemical binding]; other site 688270007605 putative ATP binding site [chemical binding]; other site 688270007606 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 688270007607 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 688270007608 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 688270007609 Soluble P-type ATPase [General function prediction only]; Region: COG4087 688270007610 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 688270007611 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 688270007612 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 688270007613 active site 688270007614 nucleophile elbow; other site 688270007615 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 688270007616 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 688270007617 active site 688270007618 putative catalytic site [active] 688270007619 DNA binding site [nucleotide binding] 688270007620 putative phosphate binding site [ion binding]; other site 688270007621 metal binding site A [ion binding]; metal-binding site 688270007622 AP binding site [nucleotide binding]; other site 688270007623 metal binding site B [ion binding]; metal-binding site 688270007624 MgtC family; Region: MgtC; pfam02308 688270007625 Predicted membrane protein [Function unknown]; Region: COG3174 688270007626 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 688270007627 ABC1 family; Region: ABC1; cl17513 688270007628 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 688270007629 propionate/acetate kinase; Provisional; Region: PRK12379 688270007630 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 688270007631 phosphate acetyltransferase; Reviewed; Region: PRK05632 688270007632 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 688270007633 DRTGG domain; Region: DRTGG; pfam07085 688270007634 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 688270007635 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 688270007636 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 688270007637 HlyD family secretion protein; Region: HlyD_3; pfam13437 688270007638 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 688270007639 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 688270007640 FtsX-like permease family; Region: FtsX; pfam02687 688270007641 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 688270007642 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 688270007643 Walker A/P-loop; other site 688270007644 ATP binding site [chemical binding]; other site 688270007645 Q-loop/lid; other site 688270007646 ABC transporter signature motif; other site 688270007647 Walker B; other site 688270007648 D-loop; other site 688270007649 H-loop/switch region; other site 688270007650 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 688270007651 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 688270007652 chaperone protein DnaJ; Provisional; Region: PRK14299 688270007653 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 688270007654 HSP70 interaction site [polypeptide binding]; other site 688270007655 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 688270007656 dimer interface [polypeptide binding]; other site 688270007657 Response regulator receiver domain; Region: Response_reg; pfam00072 688270007658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270007659 active site 688270007660 phosphorylation site [posttranslational modification] 688270007661 intermolecular recognition site; other site 688270007662 dimerization interface [polypeptide binding]; other site 688270007663 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 688270007664 Ligand binding site; other site 688270007665 Ligand binding site; other site 688270007666 Ligand binding site; other site 688270007667 Putative Catalytic site; other site 688270007668 DXD motif; other site 688270007669 Predicted integral membrane protein [Function unknown]; Region: COG5617 688270007670 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 688270007671 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 688270007672 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 688270007673 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 688270007674 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 688270007675 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270007676 TPR motif; other site 688270007677 binding surface 688270007678 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270007679 binding surface 688270007680 TPR motif; other site 688270007681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270007682 binding surface 688270007683 TPR motif; other site 688270007684 Tetratricopeptide repeat; Region: TPR_16; pfam13432 688270007685 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 688270007686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270007687 active site 688270007688 phosphorylation site [posttranslational modification] 688270007689 intermolecular recognition site; other site 688270007690 dimerization interface [polypeptide binding]; other site 688270007691 LytTr DNA-binding domain; Region: LytTR; smart00850 688270007692 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270007693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270007694 ATP binding site [chemical binding]; other site 688270007695 Mg2+ binding site [ion binding]; other site 688270007696 G-X-G motif; other site 688270007697 Uncharacterized conserved protein [Function unknown]; Region: COG3287 688270007698 FIST N domain; Region: FIST; pfam08495 688270007699 FIST C domain; Region: FIST_C; pfam10442 688270007700 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270007701 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 688270007702 putative active site [active] 688270007703 heme pocket [chemical binding]; other site 688270007704 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270007705 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 688270007706 putative active site [active] 688270007707 heme pocket [chemical binding]; other site 688270007708 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 688270007709 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270007710 putative active site [active] 688270007711 heme pocket [chemical binding]; other site 688270007712 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270007713 dimer interface [polypeptide binding]; other site 688270007714 phosphorylation site [posttranslational modification] 688270007715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270007716 ATP binding site [chemical binding]; other site 688270007717 Mg2+ binding site [ion binding]; other site 688270007718 G-X-G motif; other site 688270007719 Heme NO binding; Region: HNOB; pfam07700 688270007720 Response regulator receiver domain; Region: Response_reg; pfam00072 688270007721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270007722 active site 688270007723 phosphorylation site [posttranslational modification] 688270007724 intermolecular recognition site; other site 688270007725 dimerization interface [polypeptide binding]; other site 688270007726 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 688270007727 Na binding site [ion binding]; other site 688270007728 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 688270007729 putative catalytic site [active] 688270007730 putative metal binding site [ion binding]; other site 688270007731 putative phosphate binding site [ion binding]; other site 688270007732 OmpA family; Region: OmpA; pfam00691 688270007733 ligand binding site [chemical binding]; other site 688270007734 Uncharacterized conserved protein [Function unknown]; Region: COG1262 688270007735 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 688270007736 Uncharacterized conserved protein [Function unknown]; Region: COG1262 688270007737 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 688270007738 Uncharacterized conserved protein [Function unknown]; Region: COG1262 688270007739 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 688270007740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 688270007741 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248 688270007742 dimerization interface [polypeptide binding]; other site 688270007743 substrate binding site [chemical binding]; other site 688270007744 active site 688270007745 calcium binding site [ion binding]; other site 688270007746 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 688270007747 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 688270007748 putative NAD(P) binding site [chemical binding]; other site 688270007749 Predicted membrane protein [Function unknown]; Region: COG4270 688270007750 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 688270007751 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 688270007752 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 688270007753 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 688270007754 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 688270007755 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 688270007756 dimerization interface [polypeptide binding]; other site 688270007757 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 688270007758 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 688270007759 active site 688270007760 intersubunit interface [polypeptide binding]; other site 688270007761 catalytic residue [active] 688270007762 putative hydrolase; Provisional; Region: PRK11460 688270007763 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 688270007764 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 688270007765 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 688270007766 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 688270007767 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 688270007768 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 688270007769 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 688270007770 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 688270007771 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 688270007772 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 688270007773 Domain of unknown function DUF20; Region: UPF0118; pfam01594 688270007774 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 688270007775 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 688270007776 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 688270007777 RNA methyltransferase, RsmE family; Region: TIGR00046 688270007778 UGMP family protein; Validated; Region: PRK09604 688270007779 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 688270007780 Family of unknown function (DUF490); Region: DUF490; pfam04357 688270007781 Family of unknown function (DUF490); Region: DUF490; pfam04357 688270007782 6-phosphofructokinase; Provisional; Region: PRK03202 688270007783 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 688270007784 active site 688270007785 ADP/pyrophosphate binding site [chemical binding]; other site 688270007786 dimerization interface [polypeptide binding]; other site 688270007787 allosteric effector site; other site 688270007788 fructose-1,6-bisphosphate binding site; other site 688270007789 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 688270007790 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 688270007791 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 688270007792 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 688270007793 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 688270007794 homotrimer interaction site [polypeptide binding]; other site 688270007795 putative active site [active] 688270007796 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 688270007797 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 688270007798 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 688270007799 active site 688270007800 metal binding site [ion binding]; metal-binding site 688270007801 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 688270007802 mce related protein; Region: MCE; pfam02470 688270007803 4Fe-4S binding domain; Region: Fer4; cl02805 688270007804 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 688270007805 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 688270007806 Cysteine-rich domain; Region: CCG; pfam02754 688270007807 Cysteine-rich domain; Region: CCG; pfam02754 688270007808 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 688270007809 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 688270007810 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 688270007811 Beta-lactamase; Region: Beta-lactamase; cl17358 688270007812 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 688270007813 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 688270007814 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 688270007815 Secretoglobins are relatively small, secreted, disulphide-bridged dimeric proteins with encoding genes sharing substantial sequence similarity. Their family subunits may be grouped into five subfamilies, A-E. Uteroglobin (subfamily A), which is identical...; Region: Secretoglobin; cl11457 688270007816 Hydrophobic pocket - steroid binding site [chemical binding]; other site 688270007817 Dimer interface [polypeptide binding]; other site 688270007818 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 688270007819 Interdomain contacts; other site 688270007820 Cytokine receptor motif; other site 688270007821 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 688270007822 Interdomain contacts; other site 688270007823 Cytokine receptor motif; other site 688270007824 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 688270007825 Interdomain contacts; other site 688270007826 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 688270007827 Interdomain contacts; other site 688270007828 Cytokine receptor motif; other site 688270007829 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 688270007830 Interdomain contacts; other site 688270007831 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 688270007832 Interdomain contacts; other site 688270007833 Cytokine receptor motif; other site 688270007834 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 688270007835 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 688270007836 Heavy-metal-associated domain; Region: HMA; pfam00403 688270007837 metal-binding site [ion binding] 688270007838 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270007839 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 688270007840 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270007841 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 688270007842 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 688270007843 AMP binding site [chemical binding]; other site 688270007844 active site 688270007845 acyl-activating enzyme (AAE) consensus motif; other site 688270007846 CoA binding site [chemical binding]; other site 688270007847 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 688270007848 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 688270007849 putative trimer interface [polypeptide binding]; other site 688270007850 putative CoA binding site [chemical binding]; other site 688270007851 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 688270007852 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 688270007853 putative trimer interface [polypeptide binding]; other site 688270007854 putative CoA binding site [chemical binding]; other site 688270007855 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 688270007856 Bacterial sugar transferase; Region: Bac_transf; pfam02397 688270007857 Bacterial sugar transferase; Region: Bac_transf; pfam02397 688270007858 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 688270007859 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 688270007860 putative ADP-binding pocket [chemical binding]; other site 688270007861 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 688270007862 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 688270007863 putative ADP-binding pocket [chemical binding]; other site 688270007864 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 688270007865 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 688270007866 putative ADP-binding pocket [chemical binding]; other site 688270007867 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 688270007868 trimer interface [polypeptide binding]; other site 688270007869 active site 688270007870 substrate binding site [chemical binding]; other site 688270007871 CoA binding site [chemical binding]; other site 688270007872 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 688270007873 O-Antigen ligase; Region: Wzy_C; pfam04932 688270007874 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 688270007875 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 688270007876 putative ADP-binding pocket [chemical binding]; other site 688270007877 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 688270007878 MviN-like protein; Region: MVIN; pfam03023 688270007879 Right handed beta helix region; Region: Beta_helix; pfam13229 688270007880 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 688270007881 trimer interface [polypeptide binding]; other site 688270007882 active site 688270007883 substrate binding site [chemical binding]; other site 688270007884 CoA binding site [chemical binding]; other site 688270007885 Right handed beta helix region; Region: Beta_helix; pfam13229 688270007886 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 688270007887 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 688270007888 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 688270007889 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 688270007890 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 688270007891 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 688270007892 NAD binding site [chemical binding]; other site 688270007893 substrate binding site [chemical binding]; other site 688270007894 homodimer interface [polypeptide binding]; other site 688270007895 active site 688270007896 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 688270007897 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 688270007898 putative NAD(P) binding site [chemical binding]; other site 688270007899 active site 688270007900 putative substrate binding site [chemical binding]; other site 688270007901 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 688270007902 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 688270007903 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 688270007904 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 688270007905 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 688270007906 inhibitor-cofactor binding pocket; inhibition site 688270007907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270007908 catalytic residue [active] 688270007909 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 688270007910 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 688270007911 NAD(P) binding site [chemical binding]; other site 688270007912 homodimer interface [polypeptide binding]; other site 688270007913 substrate binding site [chemical binding]; other site 688270007914 active site 688270007915 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 688270007916 SLBB domain; Region: SLBB; pfam10531 688270007917 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 688270007918 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 688270007919 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 688270007920 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 688270007921 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 688270007922 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 688270007923 Cytochrome c; Region: Cytochrom_C; pfam00034 688270007924 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 688270007925 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 688270007926 NosL; Region: NosL; cl01769 688270007927 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 688270007928 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 688270007929 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 688270007930 Walker A/P-loop; other site 688270007931 ATP binding site [chemical binding]; other site 688270007932 Q-loop/lid; other site 688270007933 ABC transporter signature motif; other site 688270007934 Walker B; other site 688270007935 D-loop; other site 688270007936 H-loop/switch region; other site 688270007937 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 688270007938 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 688270007939 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 688270007940 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 688270007941 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 688270007942 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 688270007943 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 688270007944 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 688270007945 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 688270007946 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 688270007947 ligand binding site [chemical binding]; other site 688270007948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 688270007949 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 688270007950 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 688270007951 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 688270007952 Domain of unknown function (DUF3806); Region: DUF3806; pfam12713 688270007953 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 688270007954 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 688270007955 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 688270007956 Carbon starvation protein CstA; Region: CstA; pfam02554 688270007957 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 688270007958 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 688270007959 Carbon starvation protein CstA; Region: CstA; pfam02554 688270007960 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 688270007961 AAA domain; Region: AAA_21; pfam13304 688270007962 phosphodiesterase; Provisional; Region: PRK12704 688270007963 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 688270007964 AMP-binding site [chemical binding]; other site 688270007965 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 688270007966 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 688270007967 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 688270007968 putative NAD(P) binding site [chemical binding]; other site 688270007969 homodimer interface [polypeptide binding]; other site 688270007970 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 688270007971 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 688270007972 ligand binding site [chemical binding]; other site 688270007973 flexible hinge region; other site 688270007974 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 688270007975 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 688270007976 putative active site [active] 688270007977 putative NTP binding site [chemical binding]; other site 688270007978 putative nucleic acid binding site [nucleotide binding]; other site 688270007979 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 688270007980 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 688270007981 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 688270007982 putative active site [active] 688270007983 putative NTP binding site [chemical binding]; other site 688270007984 putative nucleic acid binding site [nucleotide binding]; other site 688270007985 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 688270007986 mobile mystery protein B; Region: mob_myst_B; TIGR02613 688270007987 Fic/DOC family; Region: Fic; pfam02661 688270007988 mobile mystery protein A; Region: mob_myst_A; TIGR02612 688270007989 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 688270007990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270007991 NAD(P) binding site [chemical binding]; other site 688270007992 active site 688270007993 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 688270007994 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 688270007995 ligand binding site [chemical binding]; other site 688270007996 flexible hinge region; other site 688270007997 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 688270007998 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 688270007999 putative active site [active] 688270008000 putative NTP binding site [chemical binding]; other site 688270008001 putative nucleic acid binding site [nucleotide binding]; other site 688270008002 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 688270008003 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 688270008004 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 688270008005 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 688270008006 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 688270008007 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 688270008008 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 688270008009 Beta-lactamase; Region: Beta-lactamase; pfam00144 688270008010 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 688270008011 TPR repeat; Region: TPR_11; pfam13414 688270008012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270008013 binding surface 688270008014 TPR motif; other site 688270008015 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 688270008016 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 688270008017 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270008018 DNA binding residues [nucleotide binding] 688270008019 ATP cone domain; Region: ATP-cone; pfam03477 688270008020 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 688270008021 dimer interface [polypeptide binding]; other site 688270008022 putative radical transfer pathway; other site 688270008023 diiron center [ion binding]; other site 688270008024 tyrosyl radical; other site 688270008025 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 688270008026 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 688270008027 Class I ribonucleotide reductase; Region: RNR_I; cd01679 688270008028 active site 688270008029 dimer interface [polypeptide binding]; other site 688270008030 catalytic residues [active] 688270008031 effector binding site; other site 688270008032 R2 peptide binding site; other site 688270008033 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 688270008034 tellurium resistance terB-like protein; Region: terB_like; cd07177 688270008035 metal binding site [ion binding]; metal-binding site 688270008036 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 688270008037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270008038 active site 688270008039 phosphorylation site [posttranslational modification] 688270008040 intermolecular recognition site; other site 688270008041 dimerization interface [polypeptide binding]; other site 688270008042 LytTr DNA-binding domain; Region: LytTR; smart00850 688270008043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270008044 binding surface 688270008045 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270008046 TPR motif; other site 688270008047 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270008048 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270008049 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 688270008050 binding surface 688270008051 TPR motif; other site 688270008052 Histidine kinase; Region: His_kinase; pfam06580 688270008053 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 688270008054 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 688270008055 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 688270008056 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 688270008057 HlyD family secretion protein; Region: HlyD_3; pfam13437 688270008058 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 688270008059 Outer membrane efflux protein; Region: OEP; pfam02321 688270008060 Outer membrane efflux protein; Region: OEP; pfam02321 688270008061 DNA polymerase IV; Validated; Region: PRK03858 688270008062 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 688270008063 active site 688270008064 DNA binding site [nucleotide binding] 688270008065 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 688270008066 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 688270008067 active site 688270008068 PHP Thumb interface [polypeptide binding]; other site 688270008069 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 688270008070 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 688270008071 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 688270008072 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 688270008073 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 688270008074 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 688270008075 GIY-YIG motif/motif A; other site 688270008076 active site 688270008077 catalytic site [active] 688270008078 putative DNA binding site [nucleotide binding]; other site 688270008079 metal binding site [ion binding]; metal-binding site 688270008080 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 688270008081 Part of AAA domain; Region: AAA_19; pfam13245 688270008082 Family description; Region: UvrD_C_2; pfam13538 688270008083 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 688270008084 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 688270008085 trmE is a tRNA modification GTPase; Region: trmE; cd04164 688270008086 G1 box; other site 688270008087 GTP/Mg2+ binding site [chemical binding]; other site 688270008088 Switch I region; other site 688270008089 G2 box; other site 688270008090 Switch II region; other site 688270008091 G3 box; other site 688270008092 G4 box; other site 688270008093 G5 box; other site 688270008094 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 688270008095 Tic20-like protein; Region: Tic20; pfam09685 688270008096 DNA polymerase III subunit beta; Validated; Region: PRK05643 688270008097 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 688270008098 putative DNA binding surface [nucleotide binding]; other site 688270008099 dimer interface [polypeptide binding]; other site 688270008100 beta-clamp/clamp loader binding surface; other site 688270008101 beta-clamp/translesion DNA polymerase binding surface; other site 688270008102 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 688270008103 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 688270008104 PhoH-like protein; Region: PhoH; pfam02562 688270008105 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 688270008106 ATP binding site [chemical binding]; other site 688270008107 active site 688270008108 substrate binding site [chemical binding]; other site 688270008109 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 688270008110 active site 688270008111 catalytic site [active] 688270008112 substrate binding site [chemical binding]; other site 688270008113 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 688270008114 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 688270008115 ligand binding site [chemical binding]; other site 688270008116 flexible hinge region; other site 688270008117 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 688270008118 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 688270008119 metal binding triad; other site 688270008120 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 688270008121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 688270008122 S-adenosylmethionine binding site [chemical binding]; other site 688270008123 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 688270008124 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 688270008125 active site 688270008126 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 688270008127 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 688270008128 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 688270008129 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 688270008130 catalytic residue [active] 688270008131 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 688270008132 Uncharacterized protein domain similar to Clostridium thermocellum 2751; Region: Cthe_2751_like; cd11743 688270008133 dimer interface [polypeptide binding]; other site 688270008134 DNA topoisomerase III; Provisional; Region: PRK07726 688270008135 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 688270008136 active site 688270008137 putative interdomain interaction site [polypeptide binding]; other site 688270008138 putative metal-binding site [ion binding]; other site 688270008139 putative nucleotide binding site [chemical binding]; other site 688270008140 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 688270008141 domain I; other site 688270008142 DNA binding groove [nucleotide binding] 688270008143 phosphate binding site [ion binding]; other site 688270008144 domain II; other site 688270008145 domain III; other site 688270008146 nucleotide binding site [chemical binding]; other site 688270008147 catalytic site [active] 688270008148 domain IV; other site 688270008149 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 688270008150 Repair protein; Region: Repair_PSII; pfam04536 688270008151 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 688270008152 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 688270008153 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 688270008154 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 688270008155 ligand binding site [chemical binding]; other site 688270008156 flexible hinge region; other site 688270008157 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 688270008158 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 688270008159 putative acyl-acceptor binding pocket; other site 688270008160 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_7; cd04502 688270008161 active site 688270008162 catalytic triad [active] 688270008163 oxyanion hole [active] 688270008164 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270008165 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270008166 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 688270008167 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270008168 starch binding outer membrane protein SusD; Region: SusD; cl17845 688270008169 SusD family; Region: SusD; pfam07980 688270008170 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270008171 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 688270008172 starch binding outer membrane protein SusD; Region: SusD; cl17845 688270008173 SusD family; Region: SusD; pfam07980 688270008174 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 688270008175 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 688270008176 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 688270008177 putative active site [active] 688270008178 putative NTP binding site [chemical binding]; other site 688270008179 putative nucleic acid binding site [nucleotide binding]; other site 688270008180 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 688270008181 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270008182 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 688270008183 PAAR motif; Region: PAAR_motif; pfam05488 688270008184 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 688270008185 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 688270008186 putative active site [active] 688270008187 putative NTP binding site [chemical binding]; other site 688270008188 putative nucleic acid binding site [nucleotide binding]; other site 688270008189 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 688270008190 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 688270008191 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 688270008192 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 688270008193 Transposase; Region: HTH_Tnp_1; cl17663 688270008194 putative transposase OrfB; Reviewed; Region: PHA02517 688270008195 HTH-like domain; Region: HTH_21; pfam13276 688270008196 Integrase core domain; Region: rve; pfam00665 688270008197 Integrase core domain; Region: rve_3; pfam13683 688270008198 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 688270008199 non-specific DNA binding site [nucleotide binding]; other site 688270008200 salt bridge; other site 688270008201 sequence-specific DNA binding site [nucleotide binding]; other site 688270008202 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 688270008203 Protein of unknown function DUF45; Region: DUF45; pfam01863 688270008204 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 688270008205 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 688270008206 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 688270008207 ATP binding site [chemical binding]; other site 688270008208 putative Mg++ binding site [ion binding]; other site 688270008209 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 688270008210 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 688270008211 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 688270008212 HsdM N-terminal domain; Region: HsdM_N; pfam12161 688270008213 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 688270008214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 688270008215 S-adenosylmethionine binding site [chemical binding]; other site 688270008216 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 688270008217 non-specific DNA binding site [nucleotide binding]; other site 688270008218 salt bridge; other site 688270008219 sequence-specific DNA binding site [nucleotide binding]; other site 688270008220 transcription factor tfb4; Region: tfb4; TIGR00627 688270008221 Repair protein; Region: Repair_PSII; pfam04536 688270008222 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270008223 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 688270008224 Beta-lactamase; Region: Beta-lactamase; pfam00144 688270008225 Helix-turn-helix domain; Region: HTH_18; pfam12833 688270008226 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 688270008227 Uncharacterized proteins similar to Bacteroides ovatus 4320; Region: Bacova_04320_like; cd12190 688270008228 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 688270008229 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 688270008230 active site 688270008231 DNA binding site [nucleotide binding] 688270008232 Int/Topo IB signature motif; other site 688270008233 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 688270008234 hydrophobic ligand binding site; other site 688270008235 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 688270008236 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 688270008237 homodimer interface [polypeptide binding]; other site 688270008238 substrate-cofactor binding pocket; other site 688270008239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270008240 catalytic residue [active] 688270008241 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 688270008242 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 688270008243 IHF - DNA interface [nucleotide binding]; other site 688270008244 IHF dimer interface [polypeptide binding]; other site 688270008245 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 688270008246 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 688270008247 putative active site [active] 688270008248 substrate binding site [chemical binding]; other site 688270008249 putative cosubstrate binding site; other site 688270008250 catalytic site [active] 688270008251 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 688270008252 substrate binding site [chemical binding]; other site 688270008253 DEAD-like helicases superfamily; Region: DEXDc; smart00487 688270008254 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 688270008255 ATP binding site [chemical binding]; other site 688270008256 putative Mg++ binding site [ion binding]; other site 688270008257 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 688270008258 nucleotide binding region [chemical binding]; other site 688270008259 ATP-binding site [chemical binding]; other site 688270008260 Predicted ATPase [General function prediction only]; Region: COG3911 688270008261 AAA domain; Region: AAA_28; pfam13521 688270008262 Protein of unknown function (DUF493); Region: DUF493; pfam04359 688270008263 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 688270008264 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 688270008265 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 688270008266 hinge; other site 688270008267 active site 688270008268 putative transposase OrfB; Reviewed; Region: PHA02517 688270008269 HTH-like domain; Region: HTH_21; pfam13276 688270008270 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 688270008271 Integrase core domain; Region: rve; pfam00665 688270008272 Integrase core domain; Region: rve_3; pfam13683 688270008273 Transposase; Region: HTH_Tnp_1; cl17663 688270008274 Winged helix-turn helix; Region: HTH_29; pfam13551 688270008275 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 688270008276 active site 688270008277 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 688270008278 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 688270008279 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 688270008280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 688270008281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 688270008282 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270008283 PAS domain; Region: PAS_9; pfam13426 688270008284 putative active site [active] 688270008285 heme pocket [chemical binding]; other site 688270008286 Family of unknown function (DUF695); Region: DUF695; pfam05117 688270008287 Pirin; Region: Pirin; pfam02678 688270008288 Pirin-related protein [General function prediction only]; Region: COG1741 688270008289 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 688270008290 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 688270008291 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 688270008292 dimer interface [polypeptide binding]; other site 688270008293 putative metal binding site [ion binding]; other site 688270008294 Integrase core domain; Region: rve; pfam00665 688270008295 Integrase core domain; Region: rve_3; pfam13683 688270008296 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 688270008297 Coenzyme A binding pocket [chemical binding]; other site 688270008298 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 688270008299 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 688270008300 DNA photolyase; Region: DNA_photolyase; pfam00875 688270008301 classical (c) SDRs; Region: SDR_c; cd05233 688270008302 NAD(P) binding site [chemical binding]; other site 688270008303 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 688270008304 active site 688270008305 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 688270008306 putative hydrophobic ligand binding site [chemical binding]; other site 688270008307 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 688270008308 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 688270008309 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 688270008310 Na binding site [ion binding]; other site 688270008311 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 688270008312 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 688270008313 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 688270008314 Mechanosensitive ion channel; Region: MS_channel; pfam00924 688270008315 Maf-like protein; Region: Maf; pfam02545 688270008316 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 688270008317 active site 688270008318 dimer interface [polypeptide binding]; other site 688270008319 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 688270008320 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 688270008321 active site 688270008322 motif I; other site 688270008323 motif II; other site 688270008324 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 688270008325 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 688270008326 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 688270008327 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 688270008328 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 688270008329 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 688270008330 homodimer interface [polypeptide binding]; other site 688270008331 substrate-cofactor binding pocket; other site 688270008332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270008333 catalytic residue [active] 688270008334 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 688270008335 Fasciclin domain; Region: Fasciclin; pfam02469 688270008336 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 688270008337 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 688270008338 putative tRNA-binding site [nucleotide binding]; other site 688270008339 B3/4 domain; Region: B3_4; pfam03483 688270008340 tRNA synthetase B5 domain; Region: B5; pfam03484 688270008341 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 688270008342 dimer interface [polypeptide binding]; other site 688270008343 motif 1; other site 688270008344 motif 3; other site 688270008345 motif 2; other site 688270008346 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 688270008347 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 688270008348 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 688270008349 catalytic residues [active] 688270008350 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 688270008351 tartrate dehydrogenase; Region: TTC; TIGR02089 688270008352 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 688270008353 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 688270008354 active site 688270008355 catalytic residues [active] 688270008356 metal binding site [ion binding]; metal-binding site 688270008357 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 688270008358 EamA-like transporter family; Region: EamA; pfam00892 688270008359 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 688270008360 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 688270008361 active site 688270008362 lipoprotein signal peptidase; Provisional; Region: PRK14787 688270008363 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 688270008364 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 688270008365 oligomerization interface [polypeptide binding]; other site 688270008366 active site 688270008367 metal binding site [ion binding]; metal-binding site 688270008368 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 688270008369 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 688270008370 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 688270008371 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 688270008372 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 688270008373 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 688270008374 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 688270008375 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 688270008376 active site 688270008377 DNA binding site [nucleotide binding] 688270008378 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 688270008379 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 688270008380 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 688270008381 nucleotide binding site [chemical binding]; other site 688270008382 NEF interaction site [polypeptide binding]; other site 688270008383 SBD interface [polypeptide binding]; other site 688270008384 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 688270008385 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 688270008386 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 688270008387 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 688270008388 Serine hydrolase (FSH1); Region: FSH1; pfam03959 688270008389 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 688270008390 CoenzymeA binding site [chemical binding]; other site 688270008391 subunit interaction site [polypeptide binding]; other site 688270008392 PHB binding site; other site 688270008393 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 688270008394 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 688270008395 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 688270008396 dimer interface [polypeptide binding]; other site 688270008397 tetramer interface [polypeptide binding]; other site 688270008398 PYR/PP interface [polypeptide binding]; other site 688270008399 TPP binding site [chemical binding]; other site 688270008400 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 688270008401 TPP-binding site; other site 688270008402 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 688270008403 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 688270008404 S1 domain; Region: S1_2; pfam13509 688270008405 Sporulation related domain; Region: SPOR; cl10051 688270008406 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 688270008407 UbiA prenyltransferase family; Region: UbiA; pfam01040 688270008408 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 688270008409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270008410 active site 688270008411 phosphorylation site [posttranslational modification] 688270008412 intermolecular recognition site; other site 688270008413 dimerization interface [polypeptide binding]; other site 688270008414 LytTr DNA-binding domain; Region: LytTR; smart00850 688270008415 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 688270008416 Histidine kinase; Region: HisKA_2; pfam07568 688270008417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270008418 ATP binding site [chemical binding]; other site 688270008419 Mg2+ binding site [ion binding]; other site 688270008420 G-X-G motif; other site 688270008421 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 688270008422 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 688270008423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270008424 short chain dehydrogenase; Provisional; Region: PRK06181 688270008425 NAD(P) binding site [chemical binding]; other site 688270008426 active site 688270008427 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 688270008428 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 688270008429 active site 688270008430 CAAX protease self-immunity; Region: Abi; pfam02517 688270008431 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 688270008432 AMP binding site [chemical binding]; other site 688270008433 active site 688270008434 acyl-activating enzyme (AAE) consensus motif; other site 688270008435 CoA binding site [chemical binding]; other site 688270008436 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270008437 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 688270008438 von Willebrand factor; Region: vWF_A; pfam12450 688270008439 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 688270008440 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 688270008441 metal ion-dependent adhesion site (MIDAS); other site 688270008442 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 688270008443 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 688270008444 active site 688270008445 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 688270008446 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 688270008447 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 688270008448 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 688270008449 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 688270008450 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 688270008451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 688270008452 Walker A/P-loop; other site 688270008453 ATP binding site [chemical binding]; other site 688270008454 Q-loop/lid; other site 688270008455 ABC transporter signature motif; other site 688270008456 Walker B; other site 688270008457 D-loop; other site 688270008458 H-loop/switch region; other site 688270008459 ABC transporter; Region: ABC_tran_2; pfam12848 688270008460 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 688270008461 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 688270008462 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 688270008463 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 688270008464 Coenzyme A binding pocket [chemical binding]; other site 688270008465 fumarate hydratase; Reviewed; Region: fumC; PRK00485 688270008466 Class II fumarases; Region: Fumarase_classII; cd01362 688270008467 active site 688270008468 tetramer interface [polypeptide binding]; other site 688270008469 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270008470 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 688270008471 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270008472 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 688270008473 ArsC family; Region: ArsC; pfam03960 688270008474 catalytic residues [active] 688270008475 peptide chain release factor 2; Validated; Region: prfB; PRK00578 688270008476 PCRF domain; Region: PCRF; pfam03462 688270008477 RF-1 domain; Region: RF-1; pfam00472 688270008478 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 688270008479 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 688270008480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 688270008481 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 688270008482 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 688270008483 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 688270008484 active site 688270008485 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 688270008486 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 688270008487 tetramer interface [polypeptide binding]; other site 688270008488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270008489 catalytic residue [active] 688270008490 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 688270008491 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 688270008492 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 688270008493 ligand binding site [chemical binding]; other site 688270008494 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 688270008495 catalytic residues [active] 688270008496 hypothetical protein; Provisional; Region: PRK14623 688270008497 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 688270008498 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 688270008499 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 688270008500 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 688270008501 dimer interface [polypeptide binding]; other site 688270008502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270008503 catalytic residue [active] 688270008504 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 688270008505 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 688270008506 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 688270008507 catalytic residue [active] 688270008508 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 688270008509 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 688270008510 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 688270008511 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 688270008512 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 688270008513 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 688270008514 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 688270008515 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 688270008516 Walker A/P-loop; other site 688270008517 ATP binding site [chemical binding]; other site 688270008518 Q-loop/lid; other site 688270008519 ABC transporter signature motif; other site 688270008520 Walker B; other site 688270008521 D-loop; other site 688270008522 H-loop/switch region; other site 688270008523 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 688270008524 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 688270008525 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270008526 DNA binding residues [nucleotide binding] 688270008527 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 688270008528 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 688270008529 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270008530 DNA binding residues [nucleotide binding] 688270008531 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 688270008532 endonuclease III; Region: ENDO3c; smart00478 688270008533 minor groove reading motif; other site 688270008534 helix-hairpin-helix signature motif; other site 688270008535 substrate binding pocket [chemical binding]; other site 688270008536 active site 688270008537 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 688270008538 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 688270008539 catalytic triad [active] 688270008540 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 688270008541 active site 688270008542 DNA binding site [nucleotide binding] 688270008543 Int/Topo IB signature motif; other site 688270008544 cellulose synthase A; Region: PLN02195 688270008545 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 688270008546 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 688270008547 Integrase core domain; Region: rve; pfam00665 688270008548 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 688270008549 putative hydrolase; Provisional; Region: PRK02113 688270008550 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 688270008551 Predicted esterase [General function prediction only]; Region: COG0400 688270008552 putative hydrolase; Provisional; Region: PRK11460 688270008553 dihydroorotase; Validated; Region: pyrC; PRK09357 688270008554 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 688270008555 active site 688270008556 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 688270008557 active site 688270008558 GIY-YIG motif/motif A; other site 688270008559 catalytic site [active] 688270008560 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 688270008561 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 688270008562 active site 688270008563 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 688270008564 active site 688270008565 catalytic triad [active] 688270008566 oxyanion hole [active] 688270008567 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 688270008568 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 688270008569 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 688270008570 CAAX protease self-immunity; Region: Abi; pfam02517 688270008571 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 688270008572 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 688270008573 Walker A/P-loop; other site 688270008574 ATP binding site [chemical binding]; other site 688270008575 Q-loop/lid; other site 688270008576 ABC transporter signature motif; other site 688270008577 Walker B; other site 688270008578 D-loop; other site 688270008579 H-loop/switch region; other site 688270008580 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 688270008581 homodecamer interface [polypeptide binding]; other site 688270008582 GTP cyclohydrolase I; Provisional; Region: PLN03044 688270008583 active site 688270008584 putative catalytic site residues [active] 688270008585 zinc binding site [ion binding]; other site 688270008586 GTP-CH-I/GFRP interaction surface; other site 688270008587 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 688270008588 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 688270008589 FMN binding site [chemical binding]; other site 688270008590 active site 688270008591 catalytic residues [active] 688270008592 substrate binding site [chemical binding]; other site 688270008593 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 688270008594 B12 binding site [chemical binding]; other site 688270008595 Radical SAM superfamily; Region: Radical_SAM; pfam04055 688270008596 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 688270008597 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 688270008598 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 688270008599 Galactose oxidase, central domain; Region: Kelch_3; cl02701 688270008600 Galactose oxidase, central domain; Region: Kelch_3; cl02701 688270008601 Histidine kinase; Region: His_kinase; pfam06580 688270008602 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 688270008603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270008604 active site 688270008605 phosphorylation site [posttranslational modification] 688270008606 intermolecular recognition site; other site 688270008607 dimerization interface [polypeptide binding]; other site 688270008608 LytTr DNA-binding domain; Region: LytTR; smart00850 688270008609 Endonuclease I; Region: Endonuclease_1; cl01003 688270008610 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 688270008611 Interdomain contacts; other site 688270008612 Cytokine receptor motif; other site 688270008613 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 688270008614 putative catalytic site [active] 688270008615 putative metal binding site [ion binding]; other site 688270008616 putative phosphate binding site [ion binding]; other site 688270008617 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 688270008618 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 688270008619 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 688270008620 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 688270008621 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 688270008622 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 688270008623 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 688270008624 Protein of unknown function (DUF2452); Region: DUF2452; pfam10504 688270008625 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 688270008626 Outer membrane efflux protein; Region: OEP; pfam02321 688270008627 Outer membrane efflux protein; Region: OEP; pfam02321 688270008628 HlyD family secretion protein; Region: HlyD_2; pfam12700 688270008629 HlyD family secretion protein; Region: HlyD_3; pfam13437 688270008630 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 688270008631 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 688270008632 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 688270008633 ligand binding site [chemical binding]; other site 688270008634 flexible hinge region; other site 688270008635 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 688270008636 non-specific DNA interactions [nucleotide binding]; other site 688270008637 DNA binding site [nucleotide binding] 688270008638 sequence specific DNA binding site [nucleotide binding]; other site 688270008639 putative cAMP binding site [chemical binding]; other site 688270008640 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 688270008641 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 688270008642 ApbE family; Region: ApbE; pfam02424 688270008643 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 688270008644 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 688270008645 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 688270008646 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 688270008647 Protein export membrane protein; Region: SecD_SecF; cl14618 688270008648 Protein export membrane protein; Region: SecD_SecF; cl14618 688270008649 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 688270008650 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 688270008651 HlyD family secretion protein; Region: HlyD_3; pfam13437 688270008652 Outer membrane efflux protein; Region: OEP; pfam02321 688270008653 Outer membrane efflux protein; Region: OEP; pfam02321 688270008654 methionine sulfoxide reductase B; Provisional; Region: PRK00222 688270008655 SelR domain; Region: SelR; pfam01641 688270008656 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 688270008657 methionine sulfoxide reductase A; Provisional; Region: PRK14054 688270008658 DoxX-like family; Region: DoxX_2; pfam13564 688270008659 LemA family; Region: LemA; cl00742 688270008660 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 688270008661 tetramer (dimer of dimers) interface [polypeptide binding]; other site 688270008662 active site 688270008663 dimer interface [polypeptide binding]; other site 688270008664 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 688270008665 metal-binding site [ion binding] 688270008666 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 688270008667 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 688270008668 Soluble P-type ATPase [General function prediction only]; Region: COG4087 688270008669 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 688270008670 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 688270008671 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 688270008672 Outer membrane efflux protein; Region: OEP; pfam02321 688270008673 Outer membrane efflux protein; Region: OEP; pfam02321 688270008674 HlyD family secretion protein; Region: HlyD_2; pfam12700 688270008675 HlyD family secretion protein; Region: HlyD_3; pfam13437 688270008676 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 688270008677 putative DNA binding helix; other site 688270008678 metal binding site 2 [ion binding]; metal-binding site 688270008679 metal binding site 1 [ion binding]; metal-binding site 688270008680 dimer interface [polypeptide binding]; other site 688270008681 structural Zn2+ binding site [ion binding]; other site 688270008682 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 688270008683 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 688270008684 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 688270008685 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 688270008686 metal ion-dependent adhesion site (MIDAS); other site 688270008687 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270008688 TPR motif; other site 688270008689 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270008690 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 688270008691 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 688270008692 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 688270008693 catalytic residues [active] 688270008694 dimer interface [polypeptide binding]; other site 688270008695 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 688270008696 Surface antigen; Region: Bac_surface_Ag; pfam01103 688270008697 Family of unknown function (DUF490); Region: DUF490; pfam04357 688270008698 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 688270008699 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 688270008700 4Fe-4S binding domain; Region: Fer4; pfam00037 688270008701 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 688270008702 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 688270008703 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 688270008704 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 688270008705 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 688270008706 [4Fe-4S] binding site [ion binding]; other site 688270008707 molybdopterin cofactor binding site; other site 688270008708 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 688270008709 molybdopterin cofactor binding site; other site 688270008710 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 688270008711 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 688270008712 dimer interface [polypeptide binding]; other site 688270008713 putative functional site; other site 688270008714 putative MPT binding site; other site 688270008715 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 688270008716 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 688270008717 MoaE homodimer interface [polypeptide binding]; other site 688270008718 MoaD interaction [polypeptide binding]; other site 688270008719 active site residues [active] 688270008720 glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122 688270008721 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 688270008722 active site 688270008723 trimer interface [polypeptide binding]; other site 688270008724 allosteric site; other site 688270008725 active site lid [active] 688270008726 hexamer (dimer of trimers) interface [polypeptide binding]; other site 688270008727 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 688270008728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 688270008729 RDD family; Region: RDD; cl00746 688270008730 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 688270008731 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 688270008732 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 688270008733 metal binding site [ion binding]; metal-binding site 688270008734 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 688270008735 PAS domain; Region: PAS_9; pfam13426 688270008736 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 688270008737 dimer interface [polypeptide binding]; other site 688270008738 phosphorylation site [posttranslational modification] 688270008739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270008740 ATP binding site [chemical binding]; other site 688270008741 Mg2+ binding site [ion binding]; other site 688270008742 G-X-G motif; other site 688270008743 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 688270008744 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 688270008745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270008746 dimer interface [polypeptide binding]; other site 688270008747 phosphorylation site [posttranslational modification] 688270008748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270008749 ATP binding site [chemical binding]; other site 688270008750 Mg2+ binding site [ion binding]; other site 688270008751 G-X-G motif; other site 688270008752 Predicted membrane protein [Function unknown]; Region: COG2323 688270008753 hypothetical protein; Provisional; Region: PRK09897 688270008754 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 688270008755 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 688270008756 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 688270008757 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 688270008758 catalytic site [active] 688270008759 active site 688270008760 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 688270008761 short chain dehydrogenase; Provisional; Region: PRK06701 688270008762 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 688270008763 NAD binding site [chemical binding]; other site 688270008764 metal binding site [ion binding]; metal-binding site 688270008765 active site 688270008766 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 688270008767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270008768 active site 688270008769 phosphorylation site [posttranslational modification] 688270008770 intermolecular recognition site; other site 688270008771 dimerization interface [polypeptide binding]; other site 688270008772 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 688270008773 hydroperoxidase II; Provisional; Region: katE; PRK11249 688270008774 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 688270008775 tetramer interface [polypeptide binding]; other site 688270008776 heme binding pocket [chemical binding]; other site 688270008777 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 688270008778 domain interactions; other site 688270008779 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 688270008780 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 688270008781 Cl- selectivity filter; other site 688270008782 Cl- binding residues [ion binding]; other site 688270008783 pore gating glutamate residue; other site 688270008784 dimer interface [polypeptide binding]; other site 688270008785 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 688270008786 Beta-lactamase; Region: Beta-lactamase; pfam00144 688270008787 Resistant to P. syringae 6; Provisional; Region: PLN03210 688270008788 Resistant to P. syringae 6; Provisional; Region: PLN03210 688270008789 RbsD / FucU transport protein family; Region: RbsD_FucU; pfam05025 688270008790 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 688270008791 classical (c) SDRs; Region: SDR_c; cd05233 688270008792 NAD(P) binding site [chemical binding]; other site 688270008793 active site 688270008794 Alginate lyase; Region: Alginate_lyase2; pfam08787 688270008795 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 688270008796 putative catalytic residues [active] 688270008797 beta-D-glucuronidase; Provisional; Region: PRK10150 688270008798 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 688270008799 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 688270008800 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 688270008801 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 688270008802 starch binding outer membrane protein SusD; Region: SusD; cd08977 688270008803 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270008804 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270008805 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270008806 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 688270008807 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 688270008808 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270008809 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270008810 dimer interface [polypeptide binding]; other site 688270008811 phosphorylation site [posttranslational modification] 688270008812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270008813 ATP binding site [chemical binding]; other site 688270008814 Mg2+ binding site [ion binding]; other site 688270008815 G-X-G motif; other site 688270008816 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 688270008817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270008818 active site 688270008819 phosphorylation site [posttranslational modification] 688270008820 intermolecular recognition site; other site 688270008821 dimerization interface [polypeptide binding]; other site 688270008822 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 688270008823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 688270008824 PKD domain; Region: PKD; pfam00801 688270008825 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 688270008826 putative metal binding site [ion binding]; other site 688270008827 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 688270008828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 688270008829 putative substrate translocation pore; other site 688270008830 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 688270008831 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 688270008832 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 688270008833 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 688270008834 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 688270008835 putative trimer interface [polypeptide binding]; other site 688270008836 putative CoA binding site [chemical binding]; other site 688270008837 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 688270008838 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 688270008839 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 688270008840 Fic/DOC family; Region: Fic; pfam02661 688270008841 Divergent AAA domain; Region: AAA_4; pfam04326 688270008842 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 688270008843 HsdM N-terminal domain; Region: HsdM_N; pfam12161 688270008844 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 688270008845 Methyltransferase domain; Region: Methyltransf_26; pfam13659 688270008846 S-adenosylmethionine binding site [chemical binding]; other site 688270008847 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 688270008848 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 688270008849 AAA domain; Region: AAA_21; pfam13304 688270008850 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 688270008851 Q-loop/lid; other site 688270008852 ABC transporter signature motif; other site 688270008853 Walker B; other site 688270008854 D-loop; other site 688270008855 H-loop/switch region; other site 688270008856 Uncharacterized conserved protein [Function unknown]; Region: COG1479 688270008857 Protein of unknown function DUF262; Region: DUF262; pfam03235 688270008858 Uncharacterized conserved protein [Function unknown]; Region: COG1479 688270008859 Protein of unknown function DUF262; Region: DUF262; pfam03235 688270008860 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 688270008861 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 688270008862 GIY-YIG motif/motif A; other site 688270008863 putative active site [active] 688270008864 putative metal binding site [ion binding]; other site 688270008865 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 688270008866 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 688270008867 dimer interface [polypeptide binding]; other site 688270008868 FMN binding site [chemical binding]; other site 688270008869 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 688270008870 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 688270008871 inhibitor-cofactor binding pocket; inhibition site 688270008872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270008873 catalytic residue [active] 688270008874 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 688270008875 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 688270008876 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 688270008877 dimerization interface [polypeptide binding]; other site 688270008878 active site 688270008879 Predicted permeases [General function prediction only]; Region: COG0795 688270008880 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 688270008881 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 688270008882 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 688270008883 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 688270008884 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 688270008885 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 688270008886 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 688270008887 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 688270008888 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 688270008889 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 688270008890 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 688270008891 dimer interface [polypeptide binding]; other site 688270008892 catalytic triad [active] 688270008893 peroxidatic and resolving cysteines [active] 688270008894 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 688270008895 catalytic residues [active] 688270008896 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 688270008897 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 688270008898 dimer interface [polypeptide binding]; other site 688270008899 decamer (pentamer of dimers) interface [polypeptide binding]; other site 688270008900 catalytic triad [active] 688270008901 peroxidatic and resolving cysteines [active] 688270008902 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 688270008903 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 688270008904 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 688270008905 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 688270008906 catalytic residue [active] 688270008907 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 688270008908 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 688270008909 dimerization interface [polypeptide binding]; other site 688270008910 putative DNA binding site [nucleotide binding]; other site 688270008911 putative Zn2+ binding site [ion binding]; other site 688270008912 AsnC family; Region: AsnC_trans_reg; pfam01037 688270008913 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 688270008914 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 688270008915 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 688270008916 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 688270008917 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 688270008918 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 688270008919 active site 688270008920 catalytic tetrad [active] 688270008921 CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704 688270008922 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 688270008923 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 688270008924 Acyltransferase family; Region: Acyl_transf_3; pfam01757 688270008925 Predicted flavoprotein [General function prediction only]; Region: COG0431 688270008926 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 688270008927 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 688270008928 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 688270008929 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 688270008930 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 688270008931 Ligand Binding Site [chemical binding]; other site 688270008932 TilS substrate C-terminal domain; Region: TilS_C; smart00977 688270008933 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 688270008934 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 688270008935 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 688270008936 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270008937 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 688270008938 putative active site [active] 688270008939 heme pocket [chemical binding]; other site 688270008940 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 688270008941 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 688270008942 heme pocket [chemical binding]; other site 688270008943 putative active site [active] 688270008944 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 688270008945 heme pocket [chemical binding]; other site 688270008946 putative active site [active] 688270008947 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270008948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270008949 ATP binding site [chemical binding]; other site 688270008950 Mg2+ binding site [ion binding]; other site 688270008951 G-X-G motif; other site 688270008952 Response regulator receiver domain; Region: Response_reg; pfam00072 688270008953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270008954 active site 688270008955 phosphorylation site [posttranslational modification] 688270008956 intermolecular recognition site; other site 688270008957 dimerization interface [polypeptide binding]; other site 688270008958 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 688270008959 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 688270008960 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 688270008961 active site 688270008962 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 688270008963 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270008964 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270008965 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 688270008966 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 688270008967 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 688270008968 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 688270008969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 688270008970 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 688270008971 Walker A motif; other site 688270008972 ATP binding site [chemical binding]; other site 688270008973 Walker B motif; other site 688270008974 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 688270008975 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 688270008976 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 688270008977 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 688270008978 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_1; cd10801 688270008979 putative active site [active] 688270008980 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 688270008981 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 688270008982 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 688270008983 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 688270008984 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 688270008985 NAD(P) binding site [chemical binding]; other site 688270008986 catalytic residues [active] 688270008987 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 688270008988 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 688270008989 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 688270008990 PYR/PP interface [polypeptide binding]; other site 688270008991 dimer interface [polypeptide binding]; other site 688270008992 TPP binding site [chemical binding]; other site 688270008993 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 688270008994 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 688270008995 TPP-binding site [chemical binding]; other site 688270008996 dimer interface [polypeptide binding]; other site 688270008997 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 688270008998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 688270008999 S-adenosylmethionine binding site [chemical binding]; other site 688270009000 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 688270009001 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 688270009002 putative valine binding site [chemical binding]; other site 688270009003 dimer interface [polypeptide binding]; other site 688270009004 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 688270009005 ketol-acid reductoisomerase; Validated; Region: PRK05225 688270009006 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 688270009007 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 688270009008 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 688270009009 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 688270009010 active site 688270009011 catalytic residues [active] 688270009012 threonine dehydratase; Validated; Region: PRK08639 688270009013 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 688270009014 tetramer interface [polypeptide binding]; other site 688270009015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270009016 catalytic residue [active] 688270009017 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 688270009018 putative Ile/Val binding site [chemical binding]; other site 688270009019 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 688270009020 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 688270009021 tetrameric interface [polypeptide binding]; other site 688270009022 activator binding site; other site 688270009023 NADP binding site [chemical binding]; other site 688270009024 substrate binding site [chemical binding]; other site 688270009025 catalytic residues [active] 688270009026 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270009027 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 688270009028 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 688270009029 MFS transport protein AraJ; Provisional; Region: PRK10091 688270009030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 688270009031 putative substrate translocation pore; other site 688270009032 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 688270009033 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 688270009034 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 688270009035 Clp amino terminal domain; Region: Clp_N; pfam02861 688270009036 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 688270009037 Walker A motif; other site 688270009038 ATP binding site [chemical binding]; other site 688270009039 Walker B motif; other site 688270009040 arginine finger; other site 688270009041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 688270009042 Walker A motif; other site 688270009043 ATP binding site [chemical binding]; other site 688270009044 Walker B motif; other site 688270009045 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 688270009046 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 688270009047 fumarylacetoacetase; Region: PLN02856 688270009048 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 688270009049 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 688270009050 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 688270009051 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 688270009052 dimer interface [polypeptide binding]; other site 688270009053 active site 688270009054 glycine-pyridoxal phosphate binding site [chemical binding]; other site 688270009055 folate binding site [chemical binding]; other site 688270009056 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 688270009057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270009058 active site 688270009059 phosphorylation site [posttranslational modification] 688270009060 intermolecular recognition site; other site 688270009061 dimerization interface [polypeptide binding]; other site 688270009062 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270009063 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270009064 TPR motif; other site 688270009065 binding surface 688270009066 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270009067 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270009068 binding surface 688270009069 TPR motif; other site 688270009070 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 688270009071 Histidine kinase; Region: HisKA_3; pfam07730 688270009072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270009073 ATP binding site [chemical binding]; other site 688270009074 Mg2+ binding site [ion binding]; other site 688270009075 G-X-G motif; other site 688270009076 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 688270009077 LytTr DNA-binding domain; Region: LytTR; smart00850 688270009078 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 688270009079 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 688270009080 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 688270009081 active site 688270009082 Glutamine cyclotransferase; Region: Glu_cyclase_2; pfam05096 688270009083 short chain dehydrogenase; Provisional; Region: PRK06179 688270009084 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 688270009085 NADP binding site [chemical binding]; other site 688270009086 active site 688270009087 steroid binding site; other site 688270009088 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 688270009089 active site 688270009090 intersubunit interactions; other site 688270009091 catalytic residue [active] 688270009092 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 688270009093 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 688270009094 Walker A/P-loop; other site 688270009095 ATP binding site [chemical binding]; other site 688270009096 Q-loop/lid; other site 688270009097 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 688270009098 ABC transporter; Region: ABC_tran_2; pfam12848 688270009099 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 688270009100 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 688270009101 tartrate dehydrogenase; Region: TTC; TIGR02089 688270009102 (R)-citramalate synthase; Provisional; Region: PRK09389 688270009103 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 688270009104 active site 688270009105 catalytic residues [active] 688270009106 metal binding site [ion binding]; metal-binding site 688270009107 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 688270009108 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 688270009109 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 688270009110 substrate binding site [chemical binding]; other site 688270009111 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 688270009112 four helix bundle protein; Region: TIGR02436 688270009113 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 688270009114 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 688270009115 substrate binding site [chemical binding]; other site 688270009116 ligand binding site [chemical binding]; other site 688270009117 Domain of unknown function (DUF4138); Region: DUF4138; pfam13595 688270009118 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 688270009119 Repair protein; Region: Repair_PSII; pfam04536 688270009120 Repair protein; Region: Repair_PSII; pfam04536 688270009121 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 688270009122 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 688270009123 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 688270009124 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 688270009125 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 688270009126 active site 688270009127 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 688270009128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 688270009129 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 688270009130 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 688270009131 RHS protein; Region: RHS; pfam03527 688270009132 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 688270009133 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 688270009134 RHS Repeat; Region: RHS_repeat; pfam05593 688270009135 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 688270009136 RHS protein; Region: RHS; pfam03527 688270009137 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 688270009138 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 688270009139 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 688270009140 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 688270009141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 688270009142 Walker A motif; other site 688270009143 ATP binding site [chemical binding]; other site 688270009144 Walker B motif; other site 688270009145 arginine finger; other site 688270009146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 688270009147 ATP binding site [chemical binding]; other site 688270009148 Walker B motif; other site 688270009149 arginine finger; other site 688270009150 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 688270009151 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 688270009152 NlpC/P60 family; Region: NLPC_P60; pfam00877 688270009153 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 688270009154 PKD domain; Region: PKD; pfam00801 688270009155 NADH:ubiquinone oxidoreductase; Provisional; Region: PTZ00305 688270009156 Protein of unknown function (DUF877); Region: DUF877; pfam05943 688270009157 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 688270009158 Domain of unknown function (DUF4138); Region: DUF4138; pfam13595 688270009159 Conjugative transposon protein TraO; Region: TraO; pfam10626 688270009160 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 688270009161 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 688270009162 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 688270009163 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 688270009164 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 688270009165 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 688270009166 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 688270009167 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 688270009168 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 688270009169 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 688270009170 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 688270009171 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 688270009172 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 688270009173 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 688270009174 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 688270009175 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 688270009176 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 688270009177 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 688270009178 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 688270009179 generic binding surface II; other site 688270009180 ssDNA binding site; other site 688270009181 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 688270009182 ATP binding site [chemical binding]; other site 688270009183 putative Mg++ binding site [ion binding]; other site 688270009184 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 688270009185 nucleotide binding region [chemical binding]; other site 688270009186 ATP-binding site [chemical binding]; other site 688270009187 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 688270009188 Zn binding site [ion binding]; other site 688270009189 Patatin-like phospholipase; Region: Patatin; pfam01734 688270009190 active site 688270009191 nucleophile elbow; other site 688270009192 Patatin-like phospholipase; Region: Patatin; pfam01734 688270009193 active site 688270009194 nucleophile elbow; other site 688270009195 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 688270009196 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 688270009197 active site 688270009198 FMN binding site [chemical binding]; other site 688270009199 substrate binding site [chemical binding]; other site 688270009200 3Fe-4S cluster binding site [ion binding]; other site 688270009201 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 688270009202 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 688270009203 metal binding site [ion binding]; metal-binding site 688270009204 putative dimer interface [polypeptide binding]; other site 688270009205 DsrE/DsrF-like family; Region: DrsE; pfam02635 688270009206 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 688270009207 Part of AAA domain; Region: AAA_19; pfam13245 688270009208 Family description; Region: UvrD_C_2; pfam13538 688270009209 Uncharacterized conserved protein [Function unknown]; Region: COG1359 688270009210 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 688270009211 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 688270009212 putative metal binding site [ion binding]; other site 688270009213 PhoD-like phosphatase; Region: PhoD; pfam09423 688270009214 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 688270009215 putative active site [active] 688270009216 putative metal binding site [ion binding]; other site 688270009217 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 688270009218 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 688270009219 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 688270009220 ligand binding site [chemical binding]; other site 688270009221 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 688270009222 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 688270009223 Probable Catalytic site; other site 688270009224 metal-binding site 688270009225 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 688270009226 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 688270009227 DNA polymerase III, delta subunit; Region: holA; TIGR01128 688270009228 Predicted membrane protein [Function unknown]; Region: COG2259 688270009229 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 688270009230 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 688270009231 tetramer interface [polypeptide binding]; other site 688270009232 TPP-binding site [chemical binding]; other site 688270009233 heterodimer interface [polypeptide binding]; other site 688270009234 phosphorylation loop region [posttranslational modification] 688270009235 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 688270009236 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 688270009237 PYR/PP interface [polypeptide binding]; other site 688270009238 dimer interface [polypeptide binding]; other site 688270009239 TPP binding site [chemical binding]; other site 688270009240 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 688270009241 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 688270009242 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 688270009243 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 688270009244 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 688270009245 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 688270009246 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 688270009247 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 688270009248 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 688270009249 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 688270009250 FeS/SAM binding site; other site 688270009251 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 688270009252 non-specific DNA binding site [nucleotide binding]; other site 688270009253 salt bridge; other site 688270009254 Predicted transcriptional regulator [Transcription]; Region: COG2932 688270009255 sequence-specific DNA binding site [nucleotide binding]; other site 688270009256 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 688270009257 Catalytic site [active] 688270009258 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 688270009259 HD domain; Region: HD_4; pfam13328 688270009260 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 688270009261 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 688270009262 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 688270009263 Protein of unknown function, DUF479; Region: DUF479; cl01203 688270009264 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 688270009265 This PGM-like (phosphoglucomutase-like) domain is located C-terminal to a mannose-1-phosphate guanyltransferase domain in a protein of unknown function that is found in both prokaryotes and eukaryotes. This domain belongs to the alpha-D-phosphohexomutase...; Region: PGM_like4; cd05803 688270009266 active site 688270009267 substrate binding site [chemical binding]; other site 688270009268 metal binding site [ion binding]; metal-binding site 688270009269 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 688270009270 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 688270009271 putative acyl-acceptor binding pocket; other site 688270009272 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 688270009273 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 688270009274 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 688270009275 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 688270009276 catalytic residues [active] 688270009277 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 688270009278 FAD binding domain; Region: FAD_binding_4; pfam01565 688270009279 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 688270009280 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 688270009281 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 688270009282 putative active site [active] 688270009283 putative metal binding site [ion binding]; other site 688270009284 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 688270009285 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 688270009286 Tetramer interface [polypeptide binding]; other site 688270009287 active site 688270009288 FMN-binding site [chemical binding]; other site 688270009289 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 688270009290 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 688270009291 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 688270009292 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 688270009293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 688270009294 S-adenosylmethionine binding site [chemical binding]; other site 688270009295 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 688270009296 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 688270009297 active site 688270009298 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 688270009299 active site 688270009300 catalytic residues [active] 688270009301 short chain dehydrogenase; Provisional; Region: PRK07024 688270009302 classical (c) SDRs; Region: SDR_c; cd05233 688270009303 NAD(P) binding site [chemical binding]; other site 688270009304 active site 688270009305 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 688270009306 Patatin-like phospholipase; Region: Patatin; pfam01734 688270009307 active site 688270009308 nucleophile elbow; other site 688270009309 Cytidylyltransferase family; Region: CTP_transf_1; cl17467 688270009310 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 688270009311 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 688270009312 Domain of unknown function (DUF1704); Region: DUF1704; pfam08014 688270009313 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 688270009314 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 688270009315 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270009316 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 688270009317 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 688270009318 Protein of unknown function, DUF393; Region: DUF393; pfam04134 688270009319 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270009320 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270009321 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270009322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270009323 binding surface 688270009324 TPR motif; other site 688270009325 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270009326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 688270009327 binding surface 688270009328 TPR motif; other site 688270009329 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 688270009330 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 688270009331 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 688270009332 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 688270009333 Ligand Binding Site [chemical binding]; other site 688270009334 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 688270009335 Ligand Binding Site [chemical binding]; other site 688270009336 MutS domain III; Region: MutS_III; pfam05192 688270009337 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 688270009338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 688270009339 Walker A/P-loop; other site 688270009340 ATP binding site [chemical binding]; other site 688270009341 Q-loop/lid; other site 688270009342 ABC transporter signature motif; other site 688270009343 Walker B; other site 688270009344 D-loop; other site 688270009345 H-loop/switch region; other site 688270009346 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 688270009347 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 688270009348 ligand binding site [chemical binding]; other site 688270009349 active site 688270009350 UGI interface [polypeptide binding]; other site 688270009351 catalytic site [active] 688270009352 Response regulator receiver domain; Region: Response_reg; pfam00072 688270009353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270009354 active site 688270009355 phosphorylation site [posttranslational modification] 688270009356 intermolecular recognition site; other site 688270009357 dimerization interface [polypeptide binding]; other site 688270009358 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 688270009359 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 688270009360 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 688270009361 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 688270009362 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 688270009363 putative rRNA binding site [nucleotide binding]; other site 688270009364 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 688270009365 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 688270009366 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 688270009367 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 688270009368 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 688270009369 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 688270009370 TPP-binding site [chemical binding]; other site 688270009371 tetramer interface [polypeptide binding]; other site 688270009372 heterodimer interface [polypeptide binding]; other site 688270009373 phosphorylation loop region [posttranslational modification] 688270009374 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 688270009375 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 688270009376 alpha subunit interface [polypeptide binding]; other site 688270009377 TPP binding site [chemical binding]; other site 688270009378 heterodimer interface [polypeptide binding]; other site 688270009379 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 688270009380 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 688270009381 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 688270009382 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 688270009383 ligand binding site [chemical binding]; other site 688270009384 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 688270009385 Methyltransferase domain; Region: Methyltransf_31; pfam13847 688270009386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 688270009387 S-adenosylmethionine binding site [chemical binding]; other site 688270009388 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 688270009389 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 688270009390 malonyl-CoA binding site [chemical binding]; other site 688270009391 dimer interface [polypeptide binding]; other site 688270009392 active site 688270009393 product binding site; other site 688270009394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270009395 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 688270009396 NAD(P) binding site [chemical binding]; other site 688270009397 active site 688270009398 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 688270009399 active site 2 [active] 688270009400 active site 1 [active] 688270009401 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 688270009402 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 688270009403 dimer interface [polypeptide binding]; other site 688270009404 active site 688270009405 acyl carrier protein; Provisional; Region: acpP; PRK00982 688270009406 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 688270009407 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 688270009408 30S subunit binding site; other site 688270009409 Transcriptional regulators [Transcription]; Region: PurR; COG1609 688270009410 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 688270009411 DNA binding site [nucleotide binding] 688270009412 domain linker motif; other site 688270009413 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 688270009414 dimerization interface [polypeptide binding]; other site 688270009415 ligand binding site [chemical binding]; other site 688270009416 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270009417 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 688270009418 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 688270009419 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270009420 Trehalase; Region: Trehalase; cl17346 688270009421 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 688270009422 Na binding site [ion binding]; other site 688270009423 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 688270009424 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 688270009425 nucleoside/Zn binding site; other site 688270009426 dimer interface [polypeptide binding]; other site 688270009427 catalytic motif [active] 688270009428 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 688270009429 Mechanosensitive ion channel; Region: MS_channel; pfam00924 688270009430 Right handed beta helix region; Region: Beta_helix; pfam13229 688270009431 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 688270009432 putative catalytic residues [active] 688270009433 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 688270009434 Fasciclin domain; Region: Fasciclin; pfam02469 688270009435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 688270009436 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 688270009437 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 688270009438 active site 688270009439 FMN binding site [chemical binding]; other site 688270009440 2,4-decadienoyl-CoA binding site; other site 688270009441 catalytic residue [active] 688270009442 4Fe-4S cluster binding site [ion binding]; other site 688270009443 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 688270009444 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 688270009445 LabA_like proteins; Region: LabA_like/DUF88; cl10034 688270009446 putative metal binding site [ion binding]; other site 688270009447 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 688270009448 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 688270009449 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 688270009450 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 688270009451 Fasciclin domain; Region: Fasciclin; pfam02469 688270009452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 688270009453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 688270009454 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 688270009455 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 688270009456 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 688270009457 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 688270009458 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 688270009459 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 688270009460 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 688270009461 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 688270009462 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 688270009463 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270009464 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270009465 dimer interface [polypeptide binding]; other site 688270009466 phosphorylation site [posttranslational modification] 688270009467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270009468 ATP binding site [chemical binding]; other site 688270009469 Mg2+ binding site [ion binding]; other site 688270009470 G-X-G motif; other site 688270009471 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 688270009472 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 688270009473 Substrate binding site [chemical binding]; other site 688270009474 WGR domain of bacterial DNA ligases; Region: WGR_DNA_ligase; cd07998 688270009475 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 688270009476 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 688270009477 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 688270009478 GAF domain; Region: GAF; pfam01590 688270009479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270009480 dimer interface [polypeptide binding]; other site 688270009481 phosphorylation site [posttranslational modification] 688270009482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270009483 ATP binding site [chemical binding]; other site 688270009484 Mg2+ binding site [ion binding]; other site 688270009485 G-X-G motif; other site 688270009486 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270009487 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270009488 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270009489 binding surface 688270009490 TPR motif; other site 688270009491 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270009492 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270009493 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270009494 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270009495 dimer interface [polypeptide binding]; other site 688270009496 phosphorylation site [posttranslational modification] 688270009497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270009498 ATP binding site [chemical binding]; other site 688270009499 Mg2+ binding site [ion binding]; other site 688270009500 G-X-G motif; other site 688270009501 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 688270009502 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 688270009503 FtsX-like permease family; Region: FtsX; pfam02687 688270009504 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 688270009505 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 688270009506 Walker A/P-loop; other site 688270009507 ATP binding site [chemical binding]; other site 688270009508 Q-loop/lid; other site 688270009509 ABC transporter signature motif; other site 688270009510 Walker B; other site 688270009511 D-loop; other site 688270009512 H-loop/switch region; other site 688270009513 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 688270009514 active site 688270009515 catalytic triad [active] 688270009516 oxyanion hole [active] 688270009517 switch loop; other site 688270009518 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270009519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 688270009520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 688270009521 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 688270009522 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 688270009523 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 688270009524 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 688270009525 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 688270009526 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 688270009527 active site 688270009528 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 688270009529 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 688270009530 active site 688270009531 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 688270009532 nudix motif; other site 688270009533 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 688270009534 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 688270009535 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 688270009536 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 688270009537 Outer membrane efflux protein; Region: OEP; pfam02321 688270009538 Outer membrane efflux protein; Region: OEP; pfam02321 688270009539 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 688270009540 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 688270009541 Multicopper oxidase; Region: Cu-oxidase; pfam00394 688270009542 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 688270009543 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 688270009544 Haem-binding domain; Region: Haem_bd; pfam14376 688270009545 Helix-turn-helix domain; Region: HTH_18; pfam12833 688270009546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 688270009547 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 688270009548 metal-binding site [ion binding] 688270009549 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 688270009550 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 688270009551 Soluble P-type ATPase [General function prediction only]; Region: COG4087 688270009552 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 688270009553 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 688270009554 HlyD family secretion protein; Region: HlyD_3; pfam13437 688270009555 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 688270009556 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 688270009557 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 688270009558 aromatic chitin/cellulose binding site residues [chemical binding]; other site 688270009559 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 688270009560 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 688270009561 DNA-binding site [nucleotide binding]; DNA binding site 688270009562 RNA-binding motif; other site 688270009563 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 688270009564 Mechanosensitive ion channel; Region: MS_channel; pfam00924 688270009565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 688270009566 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 688270009567 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 688270009568 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 688270009569 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 688270009570 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 688270009571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 688270009572 Uncharacterized conserved protein [Function unknown]; Region: COG2308 688270009573 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 688270009574 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 688270009575 ligand binding site [chemical binding]; other site 688270009576 flexible hinge region; other site 688270009577 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 688270009578 Fatty acid desaturase; Region: FA_desaturase; pfam00487 688270009579 Di-iron ligands [ion binding]; other site 688270009580 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 688270009581 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 688270009582 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 688270009583 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 688270009584 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 688270009585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 688270009586 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 688270009587 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 688270009588 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 688270009589 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 688270009590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 688270009591 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 688270009592 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 688270009593 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 688270009594 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 688270009595 heme-binding site [chemical binding]; other site 688270009596 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 688270009597 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 688270009598 Rrf2 family protein; Region: rrf2_super; TIGR00738 688270009599 Transcriptional regulator; Region: Rrf2; pfam02082 688270009600 Right handed beta helix region; Region: Beta_helix; pfam13229 688270009601 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 688270009602 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 688270009603 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 688270009604 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 688270009605 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270009606 DNA binding residues [nucleotide binding] 688270009607 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 688270009608 phosphate binding site [ion binding]; other site 688270009609 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 688270009610 tetramer interface [polypeptide binding]; other site 688270009611 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 688270009612 active site 688270009613 Helix-turn-helix domain; Region: HTH_18; pfam12833 688270009614 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 688270009615 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 688270009616 DoxX-like family; Region: DoxX_2; pfam13564 688270009617 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 688270009618 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 688270009619 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 688270009620 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 688270009621 HlyD family secretion protein; Region: HlyD_3; pfam13437 688270009622 OsmC-like protein; Region: OsmC; pfam02566 688270009623 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 688270009624 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 688270009625 Walker A/P-loop; other site 688270009626 ATP binding site [chemical binding]; other site 688270009627 Q-loop/lid; other site 688270009628 ABC transporter signature motif; other site 688270009629 Walker B; other site 688270009630 D-loop; other site 688270009631 H-loop/switch region; other site 688270009632 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 688270009633 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 688270009634 Walker A/P-loop; other site 688270009635 ATP binding site [chemical binding]; other site 688270009636 Q-loop/lid; other site 688270009637 ABC transporter signature motif; other site 688270009638 Walker B; other site 688270009639 D-loop; other site 688270009640 H-loop/switch region; other site 688270009641 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 688270009642 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 688270009643 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 688270009644 ABC-2 type transporter; Region: ABC2_membrane; cl17235 688270009645 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270009646 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 688270009647 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 688270009648 N-terminal plug; other site 688270009649 ligand-binding site [chemical binding]; other site 688270009650 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 688270009651 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 688270009652 Na binding site [ion binding]; other site 688270009653 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 688270009654 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 688270009655 metal binding site [ion binding]; metal-binding site 688270009656 dimer interface [polypeptide binding]; other site 688270009657 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 688270009658 Na binding site [ion binding]; other site 688270009659 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 688270009660 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 688270009661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 688270009662 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 688270009663 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 688270009664 EamA-like transporter family; Region: EamA; cl17759 688270009665 YHYH protein; Region: YHYH; pfam14240 688270009666 Alginate lyase; Region: Alginate_lyase2; pfam08787 688270009667 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 688270009668 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 688270009669 active site 688270009670 catalytic residues [active] 688270009671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 688270009672 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 688270009673 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 688270009674 ligand binding site [chemical binding]; other site 688270009675 flexible hinge region; other site 688270009676 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 688270009677 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 688270009678 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 688270009679 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 688270009680 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 688270009681 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 688270009682 dimerization interface [polypeptide binding]; other site 688270009683 DPS ferroxidase diiron center [ion binding]; other site 688270009684 ion pore; other site 688270009685 Cupin domain; Region: Cupin_2; pfam07883 688270009686 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 688270009687 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 688270009688 putative NAD(P) binding site [chemical binding]; other site 688270009689 dimer interface [polypeptide binding]; other site 688270009690 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 688270009691 dimer interface [polypeptide binding]; other site 688270009692 FMN binding site [chemical binding]; other site 688270009693 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 688270009694 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 688270009695 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 688270009696 NAD(P) binding site [chemical binding]; other site 688270009697 catalytic residues [active] 688270009698 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 688270009699 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 688270009700 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 688270009701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270009702 NAD(P) binding site [chemical binding]; other site 688270009703 active site 688270009704 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 688270009705 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 688270009706 NAD(P) binding site [chemical binding]; other site 688270009707 catalytic residues [active] 688270009708 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 688270009709 active site 688270009710 catalytic residues [active] 688270009711 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 688270009712 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 688270009713 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 688270009714 TrkA-N domain; Region: TrkA_N; pfam02254 688270009715 CotH protein; Region: CotH; pfam08757 688270009716 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 688270009717 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 688270009718 active site 688270009719 Zn binding site [ion binding]; other site 688270009720 Protein of unknown function (DUF962); Region: DUF962; cl01879 688270009721 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 688270009722 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 688270009723 Bacterial transcriptional repressor; Region: TetR; pfam13972 688270009724 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 688270009725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 688270009726 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 688270009727 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 688270009728 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 688270009729 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 688270009730 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 688270009731 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 688270009732 YARHG domain; Region: YARHG; pfam13308 688270009733 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 688270009734 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 688270009735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270009736 active site 688270009737 phosphorylation site [posttranslational modification] 688270009738 intermolecular recognition site; other site 688270009739 dimerization interface [polypeptide binding]; other site 688270009740 LytTr DNA-binding domain; Region: LytTR; smart00850 688270009741 Histidine kinase; Region: His_kinase; pfam06580 688270009742 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 688270009743 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 688270009744 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 688270009745 FeoA domain; Region: FeoA; pfam04023 688270009746 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 688270009747 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 688270009748 intersubunit interface [polypeptide binding]; other site 688270009749 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 688270009750 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 688270009751 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 688270009752 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 688270009753 ABC-ATPase subunit interface; other site 688270009754 dimer interface [polypeptide binding]; other site 688270009755 putative PBP binding regions; other site 688270009756 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 688270009757 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 688270009758 ABC-ATPase subunit interface; other site 688270009759 dimer interface [polypeptide binding]; other site 688270009760 putative PBP binding regions; other site 688270009761 Mitochondrial ATPase inhibitor, IATP; Region: IATP; pfam04568 688270009762 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 688270009763 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 688270009764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270009765 active site 688270009766 phosphorylation site [posttranslational modification] 688270009767 intermolecular recognition site; other site 688270009768 dimerization interface [polypeptide binding]; other site 688270009769 LytTr DNA-binding domain; Region: LytTR; smart00850 688270009770 Histidine kinase; Region: His_kinase; pfam06580 688270009771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 688270009772 Mg2+ binding site [ion binding]; other site 688270009773 G-X-G motif; other site 688270009774 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 688270009775 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 688270009776 FtsX-like permease family; Region: FtsX; pfam02687 688270009777 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 688270009778 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 688270009779 Walker A/P-loop; other site 688270009780 ATP binding site [chemical binding]; other site 688270009781 Q-loop/lid; other site 688270009782 ABC transporter signature motif; other site 688270009783 Walker B; other site 688270009784 D-loop; other site 688270009785 H-loop/switch region; other site 688270009786 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 688270009787 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 688270009788 HlyD family secretion protein; Region: HlyD_3; pfam13437 688270009789 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 688270009790 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270009791 binding surface 688270009792 TPR motif; other site 688270009793 TPR repeat; Region: TPR_11; pfam13414 688270009794 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 688270009795 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 688270009796 FAD binding domain; Region: FAD_binding_4; pfam01565 688270009797 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 688270009798 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270009799 NADH(P)-binding; Region: NAD_binding_10; pfam13460 688270009800 NAD(P) binding site [chemical binding]; other site 688270009801 active site 688270009802 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 688270009803 Protein of unknown function (DUF877); Region: DUF877; pfam05943 688270009804 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 688270009805 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 688270009806 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 688270009807 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 688270009808 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 688270009809 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 688270009810 NodB motif; other site 688270009811 active site 688270009812 catalytic site [active] 688270009813 metal binding site [ion binding]; metal-binding site 688270009814 TPR repeat; Region: TPR_11; pfam13414 688270009815 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270009816 binding surface 688270009817 TPR motif; other site 688270009818 TPR repeat; Region: TPR_11; pfam13414 688270009819 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 688270009820 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 688270009821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 688270009822 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 688270009823 CAAX protease self-immunity; Region: Abi; pfam02517 688270009824 LytTr DNA-binding domain; Region: LytTR; smart00850 688270009825 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 688270009826 Beta-lactamase; Region: Beta-lactamase; pfam00144 688270009827 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 688270009828 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 688270009829 Helix-turn-helix domain; Region: HTH_18; pfam12833 688270009830 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 688270009831 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 688270009832 Protein of unknown function (DUF692); Region: DUF692; cl01263 688270009833 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 688270009834 Beta-lactamase; Region: Beta-lactamase; pfam00144 688270009835 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 688270009836 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 688270009837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270009838 NAD(P) binding site [chemical binding]; other site 688270009839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270009840 active site 688270009841 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 688270009842 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 688270009843 ATP binding site [chemical binding]; other site 688270009844 putative Mg++ binding site [ion binding]; other site 688270009845 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 688270009846 nucleotide binding region [chemical binding]; other site 688270009847 ATP-binding site [chemical binding]; other site 688270009848 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 688270009849 RNA binding site [nucleotide binding]; other site 688270009850 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 688270009851 DEAD-like helicases superfamily; Region: DEXDc; smart00487 688270009852 ATP binding site [chemical binding]; other site 688270009853 putative Mg++ binding site [ion binding]; other site 688270009854 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 688270009855 nucleotide binding region [chemical binding]; other site 688270009856 ATP-binding site [chemical binding]; other site 688270009857 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 688270009858 YHYH protein; Region: YHYH; pfam14240 688270009859 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 688270009860 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 688270009861 active site 688270009862 Zn binding site [ion binding]; other site 688270009863 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 688270009864 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 688270009865 Coenzyme A binding pocket [chemical binding]; other site 688270009866 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 688270009867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 688270009868 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 688270009869 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 688270009870 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 688270009871 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 688270009872 Helix-turn-helix domain; Region: HTH_18; pfam12833 688270009873 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 688270009874 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 688270009875 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 688270009876 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 688270009877 dimer interface [polypeptide binding]; other site 688270009878 FMN binding site [chemical binding]; other site 688270009879 Prostaglandin dehydrogenases; Region: PGDH; cd05288 688270009880 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 688270009881 NAD(P) binding site [chemical binding]; other site 688270009882 substrate binding site [chemical binding]; other site 688270009883 dimer interface [polypeptide binding]; other site 688270009884 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 688270009885 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 688270009886 dimer interface [polypeptide binding]; other site 688270009887 active site 688270009888 metal binding site [ion binding]; metal-binding site 688270009889 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 688270009890 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 688270009891 potential catalytic triad [active] 688270009892 conserved cys residue [active] 688270009893 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 688270009894 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 688270009895 FMN binding site [chemical binding]; other site 688270009896 active site 688270009897 substrate binding site [chemical binding]; other site 688270009898 catalytic residue [active] 688270009899 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 688270009900 pseudouridine synthase; Region: TIGR00093 688270009901 active site 688270009902 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 688270009903 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 688270009904 EamA-like transporter family; Region: EamA; pfam00892 688270009905 EamA-like transporter family; Region: EamA; pfam00892 688270009906 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 688270009907 HSP70 interaction site [polypeptide binding]; other site 688270009908 KTSC domain; Region: KTSC; pfam13619 688270009909 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 688270009910 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 688270009911 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 688270009912 Cu(I) binding site [ion binding]; other site 688270009913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 688270009914 YHYH protein; Region: YHYH; pfam14240 688270009915 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 688270009916 EF-hand domain pair; Region: EF_hand_5; pfam13499 688270009917 Ca2+ binding site [ion binding]; other site 688270009918 Histidine kinase; Region: His_kinase; pfam06580 688270009919 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 688270009920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270009921 active site 688270009922 phosphorylation site [posttranslational modification] 688270009923 intermolecular recognition site; other site 688270009924 dimerization interface [polypeptide binding]; other site 688270009925 LytTr DNA-binding domain; Region: LytTR; smart00850 688270009926 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 688270009927 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 688270009928 ATP binding site [chemical binding]; other site 688270009929 putative Mg++ binding site [ion binding]; other site 688270009930 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 688270009931 nucleotide binding region [chemical binding]; other site 688270009932 ATP-binding site [chemical binding]; other site 688270009933 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 688270009934 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 688270009935 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 688270009936 trimer interface [polypeptide binding]; other site 688270009937 active site 688270009938 UDP-GlcNAc binding site [chemical binding]; other site 688270009939 lipid binding site [chemical binding]; lipid-binding site 688270009940 helicase 45; Provisional; Region: PTZ00424 688270009941 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 688270009942 ATP binding site [chemical binding]; other site 688270009943 putative Mg++ binding site [ion binding]; other site 688270009944 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 688270009945 nucleotide binding region [chemical binding]; other site 688270009946 ATP-binding site [chemical binding]; other site 688270009947 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 688270009948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 688270009949 S-adenosylmethionine binding site [chemical binding]; other site 688270009950 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 688270009951 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 688270009952 ATP binding site [chemical binding]; other site 688270009953 putative Mg++ binding site [ion binding]; other site 688270009954 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 688270009955 nucleotide binding region [chemical binding]; other site 688270009956 ATP-binding site [chemical binding]; other site 688270009957 RQC domain; Region: RQC; pfam09382 688270009958 HRDC domain; Region: HRDC; pfam00570 688270009959 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 688270009960 DNA-binding site [nucleotide binding]; DNA binding site 688270009961 RNA-binding motif; other site 688270009962 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 688270009963 metal-binding site 688270009964 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 688270009965 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 688270009966 XdhC Rossmann domain; Region: XdhC_C; pfam13478 688270009967 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 688270009968 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 688270009969 metal ion-dependent adhesion site (MIDAS); other site 688270009970 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 688270009971 ligand binding site [chemical binding]; other site 688270009972 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 688270009973 putative active site [active] 688270009974 Zn binding site [ion binding]; other site 688270009975 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 688270009976 amidase catalytic site [active] 688270009977 Zn binding residues [ion binding]; other site 688270009978 substrate binding site [chemical binding]; other site 688270009979 3D domain; Region: 3D; cl01439 688270009980 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 688270009981 Beta-lactamase; Region: Beta-lactamase; pfam00144 688270009982 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 688270009983 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 688270009984 ATP binding site [chemical binding]; other site 688270009985 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 688270009986 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 688270009987 substrate binding site [chemical binding]; other site 688270009988 oxyanion hole (OAH) forming residues; other site 688270009989 trimer interface [polypeptide binding]; other site 688270009990 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 688270009991 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 688270009992 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 688270009993 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 688270009994 ATP binding site [chemical binding]; other site 688270009995 putative Mg++ binding site [ion binding]; other site 688270009996 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 688270009997 nucleotide binding region [chemical binding]; other site 688270009998 ATP-binding site [chemical binding]; other site 688270009999 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 688270010000 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 688270010001 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 688270010002 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 688270010003 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270010004 DNA binding residues [nucleotide binding] 688270010005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 688270010006 TPR motif; other site 688270010007 binding surface 688270010008 Sulfatase; Region: Sulfatase; cl17466 688270010009 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 688270010010 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 688270010011 DXD motif; other site 688270010012 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 688270010013 HEAT repeats; Region: HEAT_2; pfam13646 688270010014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270010015 Response regulator receiver domain; Region: Response_reg; pfam00072 688270010016 active site 688270010017 phosphorylation site [posttranslational modification] 688270010018 intermolecular recognition site; other site 688270010019 dimerization interface [polypeptide binding]; other site 688270010020 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270010021 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270010022 dimer interface [polypeptide binding]; other site 688270010023 phosphorylation site [posttranslational modification] 688270010024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270010025 ATP binding site [chemical binding]; other site 688270010026 Mg2+ binding site [ion binding]; other site 688270010027 G-X-G motif; other site 688270010028 Response regulator receiver domain; Region: Response_reg; pfam00072 688270010029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270010030 active site 688270010031 phosphorylation site [posttranslational modification] 688270010032 intermolecular recognition site; other site 688270010033 dimerization interface [polypeptide binding]; other site 688270010034 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 688270010035 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 688270010036 serine O-acetyltransferase; Region: cysE; TIGR01172 688270010037 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 688270010038 trimer interface [polypeptide binding]; other site 688270010039 active site 688270010040 substrate binding site [chemical binding]; other site 688270010041 CoA binding site [chemical binding]; other site 688270010042 cysteine synthase B; Region: cysM; TIGR01138 688270010043 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 688270010044 dimer interface [polypeptide binding]; other site 688270010045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270010046 catalytic residue [active] 688270010047 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 688270010048 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 688270010049 oligomer interface [polypeptide binding]; other site 688270010050 metal binding site [ion binding]; metal-binding site 688270010051 metal binding site [ion binding]; metal-binding site 688270010052 Cl binding site [ion binding]; other site 688270010053 aspartate ring; other site 688270010054 basic sphincter; other site 688270010055 putative hydrophobic gate; other site 688270010056 periplasmic entrance; other site 688270010057 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 688270010058 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 688270010059 active site 688270010060 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 688270010061 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 688270010062 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 688270010063 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 688270010064 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 688270010065 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 688270010066 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 688270010067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270010068 active site 688270010069 phosphorylation site [posttranslational modification] 688270010070 intermolecular recognition site; other site 688270010071 dimerization interface [polypeptide binding]; other site 688270010072 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 688270010073 DNA binding site [nucleotide binding] 688270010074 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270010075 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 688270010076 dimerization interface [polypeptide binding]; other site 688270010077 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270010078 dimer interface [polypeptide binding]; other site 688270010079 phosphorylation site [posttranslational modification] 688270010080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270010081 ATP binding site [chemical binding]; other site 688270010082 Mg2+ binding site [ion binding]; other site 688270010083 G-X-G motif; other site 688270010084 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 688270010085 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 688270010086 metal ion-dependent adhesion site (MIDAS); other site 688270010087 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 688270010088 Transcriptional regulator [Transcription]; Region: LysR; COG0583 688270010089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 688270010090 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 688270010091 putative dimerization interface [polypeptide binding]; other site 688270010092 Predicted membrane protein [Function unknown]; Region: COG2855 688270010093 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 688270010094 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 688270010095 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 688270010096 DXD motif; other site 688270010097 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 688270010098 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 688270010099 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 688270010100 metal binding site [ion binding]; metal-binding site 688270010101 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 688270010102 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 688270010103 substrate binding site [chemical binding]; other site 688270010104 glutamase interaction surface [polypeptide binding]; other site 688270010105 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 688270010106 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 688270010107 catalytic residues [active] 688270010108 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 688270010109 Coenzyme A binding pocket [chemical binding]; other site 688270010110 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 688270010111 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 688270010112 putative active site [active] 688270010113 oxyanion strand; other site 688270010114 catalytic triad [active] 688270010115 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 688270010116 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 688270010117 active site 688270010118 motif I; other site 688270010119 motif II; other site 688270010120 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 688270010121 putative active site pocket [active] 688270010122 4-fold oligomerization interface [polypeptide binding]; other site 688270010123 metal binding residues [ion binding]; metal-binding site 688270010124 3-fold/trimer interface [polypeptide binding]; other site 688270010125 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 688270010126 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 688270010127 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270010128 homodimer interface [polypeptide binding]; other site 688270010129 catalytic residue [active] 688270010130 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 688270010131 histidinol dehydrogenase; Region: hisD; TIGR00069 688270010132 NAD binding site [chemical binding]; other site 688270010133 dimerization interface [polypeptide binding]; other site 688270010134 product binding site; other site 688270010135 substrate binding site [chemical binding]; other site 688270010136 zinc binding site [ion binding]; other site 688270010137 catalytic residues [active] 688270010138 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 688270010139 Coenzyme A binding pocket [chemical binding]; other site 688270010140 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 688270010141 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 688270010142 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 688270010143 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 688270010144 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 688270010145 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 688270010146 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 688270010147 NAD(P) binding site [chemical binding]; other site 688270010148 homotetramer interface [polypeptide binding]; other site 688270010149 homodimer interface [polypeptide binding]; other site 688270010150 active site 688270010151 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 688270010152 CoA binding domain; Region: CoA_binding; smart00881 688270010153 CoA-ligase; Region: Ligase_CoA; pfam00549 688270010154 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 688270010155 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 688270010156 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 688270010157 trimer interface [polypeptide binding]; other site 688270010158 active site 688270010159 UDP-GlcNAc binding site [chemical binding]; other site 688270010160 lipid binding site [chemical binding]; lipid-binding site 688270010161 elongation factor P; Validated; Region: PRK00529 688270010162 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 688270010163 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 688270010164 RNA binding site [nucleotide binding]; other site 688270010165 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 688270010166 RNA binding site [nucleotide binding]; other site 688270010167 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 688270010168 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 688270010169 active site 688270010170 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 688270010171 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 688270010172 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 688270010173 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 688270010174 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 688270010175 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 688270010176 trimer interface [polypeptide binding]; other site 688270010177 active site 688270010178 UDP-GlcNAc binding site [chemical binding]; other site 688270010179 lipid binding site [chemical binding]; lipid-binding site 688270010180 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 688270010181 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 688270010182 Zn2+ binding site [ion binding]; other site 688270010183 Mg2+ binding site [ion binding]; other site 688270010184 Response regulator receiver domain; Region: Response_reg; pfam00072 688270010185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270010186 active site 688270010187 phosphorylation site [posttranslational modification] 688270010188 intermolecular recognition site; other site 688270010189 dimerization interface [polypeptide binding]; other site 688270010190 PglZ domain; Region: PglZ; pfam08665 688270010191 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 688270010192 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 688270010193 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 688270010194 RIB43A; Region: RIB43A; pfam05914 688270010195 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 688270010196 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 688270010197 hexamer interface [polypeptide binding]; other site 688270010198 ligand binding site [chemical binding]; other site 688270010199 putative active site [active] 688270010200 NAD(P) binding site [chemical binding]; other site 688270010201 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 688270010202 Proline dehydrogenase; Region: Pro_dh; cl03282 688270010203 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 688270010204 active site 688270010205 dimer interface [polypeptide binding]; other site 688270010206 metal binding site [ion binding]; metal-binding site 688270010207 DinB superfamily; Region: DinB_2; pfam12867 688270010208 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 688270010209 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 688270010210 putative DNA binding site [nucleotide binding]; other site 688270010211 putative Zn2+ binding site [ion binding]; other site 688270010212 AsnC family; Region: AsnC_trans_reg; pfam01037 688270010213 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 688270010214 putative active site [active] 688270010215 Zn binding site [ion binding]; other site 688270010216 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 688270010217 non-specific DNA binding site [nucleotide binding]; other site 688270010218 salt bridge; other site 688270010219 sequence-specific DNA binding site [nucleotide binding]; other site 688270010220 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 688270010221 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 688270010222 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 688270010223 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 688270010224 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 688270010225 CAP-like domain; other site 688270010226 active site 688270010227 primary dimer interface [polypeptide binding]; other site 688270010228 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 688270010229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270010230 ATP binding site [chemical binding]; other site 688270010231 Mg2+ binding site [ion binding]; other site 688270010232 G-X-G motif; other site 688270010233 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 688270010234 ATP binding site [chemical binding]; other site 688270010235 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 688270010236 active site 688270010237 putative metal-binding site [ion binding]; other site 688270010238 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 688270010239 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 688270010240 EamA-like transporter family; Region: EamA; pfam00892 688270010241 EamA-like transporter family; Region: EamA; pfam00892 688270010242 GTP-binding protein YchF; Reviewed; Region: PRK09601 688270010243 YchF GTPase; Region: YchF; cd01900 688270010244 G1 box; other site 688270010245 GTP/Mg2+ binding site [chemical binding]; other site 688270010246 Switch I region; other site 688270010247 G2 box; other site 688270010248 Switch II region; other site 688270010249 G3 box; other site 688270010250 G4 box; other site 688270010251 G5 box; other site 688270010252 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 688270010253 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 688270010254 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 688270010255 DNA binding residues [nucleotide binding] 688270010256 FecR protein; Region: FecR; pfam04773 688270010257 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270010258 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 688270010259 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 688270010260 N-terminal plug; other site 688270010261 ligand-binding site [chemical binding]; other site 688270010262 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270010263 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 688270010264 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270010265 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 688270010266 4Fe-4S binding domain; Region: Fer4; cl02805 688270010267 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 688270010268 NAD(P) binding site [chemical binding]; other site 688270010269 catalytic residues [active] 688270010270 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 688270010271 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 688270010272 catalytic residue [active] 688270010273 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 688270010274 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 688270010275 putative ligand binding site [chemical binding]; other site 688270010276 NAD binding site [chemical binding]; other site 688270010277 dimerization interface [polypeptide binding]; other site 688270010278 catalytic site [active] 688270010279 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 688270010280 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270010281 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 688270010282 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 688270010283 N-terminal plug; other site 688270010284 ligand-binding site [chemical binding]; other site 688270010285 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 688270010286 active site 688270010287 ADP/pyrophosphate binding site [chemical binding]; other site 688270010288 dimerization interface [polypeptide binding]; other site 688270010289 allosteric effector site; other site 688270010290 fructose-1,6-bisphosphate binding site; other site 688270010291 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 688270010292 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 688270010293 substrate binding site [chemical binding]; other site 688270010294 ATP binding site [chemical binding]; other site 688270010295 Transcriptional regulators [Transcription]; Region: PurR; COG1609 688270010296 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 688270010297 DNA binding site [nucleotide binding] 688270010298 domain linker motif; other site 688270010299 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 688270010300 dimerization interface [polypeptide binding]; other site 688270010301 ligand binding site [chemical binding]; other site 688270010302 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 688270010303 classical (c) SDRs; Region: SDR_c; cd05233 688270010304 NAD(P) binding site [chemical binding]; other site 688270010305 active site 688270010306 D-galactonate transporter; Region: 2A0114; TIGR00893 688270010307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 688270010308 putative substrate translocation pore; other site 688270010309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 688270010310 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 688270010311 DNA-binding site [nucleotide binding]; DNA binding site 688270010312 Transcriptional regulators [Transcription]; Region: FadR; COG2186 688270010313 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 688270010314 Alginate lyase; Region: Alginate_lyase2; pfam08787 688270010315 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 688270010316 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 688270010317 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 688270010318 starch binding outer membrane protein SusD; Region: SusD; cd08977 688270010319 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 688270010320 Cna protein B-type domain; Region: Cna_B_2; pfam13715 688270010321 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 688270010322 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 688270010323 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 688270010324 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 688270010325 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 688270010326 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 688270010327 ligand binding site [chemical binding]; other site 688270010328 flexible hinge region; other site 688270010329 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 688270010330 active site residue [active] 688270010331 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 688270010332 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 688270010333 sulfite oxidase; Provisional; Region: PLN00177 688270010334 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 688270010335 Moco binding site; other site 688270010336 metal coordination site [ion binding]; other site 688270010337 dimerization interface [polypeptide binding]; other site 688270010338 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 688270010339 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 688270010340 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 688270010341 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 688270010342 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 688270010343 pyridoxal 5'-phosphate binding site [chemical binding]; other site 688270010344 homodimer interface [polypeptide binding]; other site 688270010345 catalytic residue [active] 688270010346 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 688270010347 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 688270010348 TrkA-C domain; Region: TrkA_C; pfam02080 688270010349 TrkA-C domain; Region: TrkA_C; pfam02080 688270010350 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 688270010351 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 688270010352 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 688270010353 active site 688270010354 homotetramer interface [polypeptide binding]; other site 688270010355 homodimer interface [polypeptide binding]; other site 688270010356 Helix-turn-helix domain; Region: HTH_18; pfam12833 688270010357 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 688270010358 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 688270010359 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 688270010360 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 688270010361 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 688270010362 Peptidase family M28; Region: Peptidase_M28; pfam04389 688270010363 metal binding site [ion binding]; metal-binding site 688270010364 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270010365 binding surface 688270010366 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270010367 TPR motif; other site 688270010368 TPR repeat; Region: TPR_11; pfam13414 688270010369 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270010370 binding surface 688270010371 TPR motif; other site 688270010372 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270010373 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270010374 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270010375 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270010376 dimer interface [polypeptide binding]; other site 688270010377 phosphorylation site [posttranslational modification] 688270010378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270010379 ATP binding site [chemical binding]; other site 688270010380 Mg2+ binding site [ion binding]; other site 688270010381 G-X-G motif; other site 688270010382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270010383 TPR motif; other site 688270010384 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270010385 binding surface 688270010386 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270010387 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270010388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270010389 ATP binding site [chemical binding]; other site 688270010390 Mg2+ binding site [ion binding]; other site 688270010391 G-X-G motif; other site 688270010392 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270010393 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 688270010394 binding surface 688270010395 TPR motif; other site 688270010396 Tetratricopeptide repeat; Region: TPR_12; pfam13424 688270010397 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270010398 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270010399 dimer interface [polypeptide binding]; other site 688270010400 phosphorylation site [posttranslational modification] 688270010401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270010402 ATP binding site [chemical binding]; other site 688270010403 G-X-G motif; other site 688270010404 Transposase domain (DUF772); Region: DUF772; pfam05598 688270010405 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 688270010406 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 688270010407 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 688270010408 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 688270010409 TPP-binding site [chemical binding]; other site 688270010410 dimer interface [polypeptide binding]; other site 688270010411 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 688270010412 PYR/PP interface [polypeptide binding]; other site 688270010413 dimer interface [polypeptide binding]; other site 688270010414 TPP binding site [chemical binding]; other site 688270010415 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 688270010416 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 688270010417 catalytic core [active] 688270010418 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 688270010419 SmpB-tmRNA interface; other site 688270010420 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 688270010421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 688270010422 S-adenosylmethionine binding site [chemical binding]; other site 688270010423 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 688270010424 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 688270010425 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 688270010426 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 688270010427 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 688270010428 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 688270010429 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 688270010430 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 688270010431 catalytic residue [active] 688270010432 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 688270010433 active site 688270010434 catalytic site [active] 688270010435 substrate binding site [chemical binding]; other site 688270010436 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 688270010437 GIY-YIG motif/motif A; other site 688270010438 active site 688270010439 catalytic site [active] 688270010440 putative DNA binding site [nucleotide binding]; other site 688270010441 metal binding site [ion binding]; metal-binding site 688270010442 Ion transport protein; Region: Ion_trans; pfam00520 688270010443 Ion channel; Region: Ion_trans_2; pfam07885 688270010444 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 688270010445 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 688270010446 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 688270010447 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 688270010448 ATP-binding site [chemical binding]; other site 688270010449 Gluconate-6-phosphate binding site [chemical binding]; other site 688270010450 Shikimate kinase; Region: SKI; pfam01202 688270010451 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 688270010452 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 688270010453 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 688270010454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 688270010455 active site 688270010456 phosphorylation site [posttranslational modification] 688270010457 intermolecular recognition site; other site 688270010458 dimerization interface [polypeptide binding]; other site 688270010459 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 688270010460 DNA binding site [nucleotide binding] 688270010461 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 688270010462 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 688270010463 dimer interface [polypeptide binding]; other site 688270010464 phosphorylation site [posttranslational modification] 688270010465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 688270010466 ATP binding site [chemical binding]; other site 688270010467 Mg2+ binding site [ion binding]; other site 688270010468 G-X-G motif; other site 688270010469 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 688270010470 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 688270010471 CoA-binding site [chemical binding]; other site 688270010472 ATP-binding [chemical binding]; other site 688270010473 YbbR-like protein; Region: YbbR; pfam07949 688270010474 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 688270010475 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 688270010476 active site 688270010477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 688270010478 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 688270010479 NAD(P) binding site [chemical binding]; other site 688270010480 active site 688270010481 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 688270010482 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 688270010483 Walker A/P-loop; other site 688270010484 ATP binding site [chemical binding]; other site 688270010485 Q-loop/lid; other site 688270010486 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 688270010487 ABC transporter signature motif; other site 688270010488 Walker B; other site 688270010489 D-loop; other site 688270010490 H-loop/switch region; other site 688270010491 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 688270010492 Flavoprotein; Region: Flavoprotein; pfam02441 688270010493 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 688270010494 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 688270010495 Outer membrane lipoprotein; Region: YfiO; pfam13525 688270010496 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 688270010497 dihydrodipicolinate synthase; Region: dapA; TIGR00674 688270010498 dimer interface [polypeptide binding]; other site 688270010499 active site 688270010500 catalytic residue [active] 688270010501 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 688270010502 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 688270010503 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 688270010504 active site 688270010505 metal binding site [ion binding]; metal-binding site 688270010506 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 688270010507 Coenzyme A binding pocket [chemical binding]; other site 688270010508 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 688270010509 DNA-binding site [nucleotide binding]; DNA binding site 688270010510 RNA-binding motif; other site 688270010511 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 688270010512 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 688270010513 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 688270010514 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 688270010515 substrate binding site [chemical binding]; other site 688270010516 ATP binding site [chemical binding]; other site 688270010517 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 688270010518 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 688270010519 nucleotide binding pocket [chemical binding]; other site 688270010520 K-X-D-G motif; other site 688270010521 catalytic site [active] 688270010522 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 688270010523 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 688270010524 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 688270010525 Dimer interface [polypeptide binding]; other site 688270010526 BRCT sequence motif; other site 688270010527 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 688270010528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 688270010529 S-adenosylmethionine binding site [chemical binding]; other site 688270010530 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 688270010531 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 688270010532 Coenzyme A binding pocket [chemical binding]; other site 688270010533 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 688270010534 catalytic motif [active] 688270010535 Zn binding site [ion binding]; other site 688270010536 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 688270010537 RibD C-terminal domain; Region: RibD_C; pfam01872 688270010538 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 688270010539 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 688270010540 Uncharacterized conserved protein [Function unknown]; Region: COG1739 688270010541 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 688270010542 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 688270010543 active site