-- dump date 20111121_011240 -- class Genbank::misc_feature -- table misc_feature_note -- id note 593907000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 593907000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 593907000003 Walker A motif; other site 593907000004 ATP binding site [chemical binding]; other site 593907000005 Walker B motif; other site 593907000006 arginine finger; other site 593907000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 593907000008 DnaA box-binding interface [nucleotide binding]; other site 593907000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 593907000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 593907000011 putative DNA binding surface [nucleotide binding]; other site 593907000012 dimer interface [polypeptide binding]; other site 593907000013 beta-clamp/clamp loader binding surface; other site 593907000014 beta-clamp/translesion DNA polymerase binding surface; other site 593907000015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 593907000017 recombination protein F; Reviewed; Region: recF; PRK00064 593907000018 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 593907000019 Walker A/P-loop; other site 593907000020 ATP binding site [chemical binding]; other site 593907000021 Q-loop/lid; other site 593907000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907000023 ABC transporter signature motif; other site 593907000024 Walker B; other site 593907000025 D-loop; other site 593907000026 H-loop/switch region; other site 593907000027 Protein of unknown function (DUF721); Region: DUF721; cl02324 593907000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 593907000029 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 593907000030 anchoring element; other site 593907000031 dimer interface [polypeptide binding]; other site 593907000032 ATP binding site [chemical binding]; other site 593907000033 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 593907000034 active site 593907000035 putative metal-binding site [ion binding]; other site 593907000036 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 593907000037 DNA gyrase subunit A; Validated; Region: PRK05560 593907000038 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 593907000039 CAP-like domain; other site 593907000040 Active site [active] 593907000041 primary dimer interface [polypeptide binding]; other site 593907000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 593907000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 593907000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 593907000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 593907000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 593907000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 593907000048 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 593907000049 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 593907000050 Sulfate transporter family; Region: Sulfate_transp; cl00967 593907000051 nodulation ABC transporter NodI; Provisional; Region: PRK13537 593907000052 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907000053 Walker A/P-loop; other site 593907000054 ATP binding site [chemical binding]; other site 593907000055 Q-loop/lid; other site 593907000056 ABC transporter signature motif; other site 593907000057 Walker B; other site 593907000058 D-loop; other site 593907000059 H-loop/switch region; other site 593907000060 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 593907000061 ABC-2 type transporter; Region: ABC2_membrane; cl11417 593907000062 ABC-2 type transporter; Region: ABC2_membrane; cl11417 593907000063 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907000064 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 593907000065 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907000066 endoglucanase; Region: PLN02420 593907000067 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 593907000068 Cellulose binding domain; Region: CBM_3; pfam00942 593907000069 Cellulose binding domain; Region: CBM_2; cl02709 593907000070 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 593907000071 active site 593907000072 Rhomboid family; Region: Rhomboid; cl11446 593907000073 Uncharacterised protein family (UPF0233); Region: UPF0233; cl11506 593907000074 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 593907000075 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 593907000076 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase_D_5; cd05830 593907000077 active site 593907000078 catalytic site [active] 593907000079 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 593907000080 Glutamine amidotransferase class-I; Region: GATase; pfam00117 593907000081 glutamine binding [chemical binding]; other site 593907000082 catalytic triad [active] 593907000083 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 593907000084 active site 593907000085 ATP binding site [chemical binding]; other site 593907000086 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 593907000087 substrate binding site [chemical binding]; other site 593907000088 activation loop (A-loop); other site 593907000089 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 593907000090 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 593907000091 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 593907000092 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 593907000093 Protein kinase domain; Region: Pkinase; pfam00069 593907000094 Catalytic domain of Protein Kinases; Region: PKc; cd00180 593907000095 active site 593907000096 ATP binding site [chemical binding]; other site 593907000097 substrate binding site [chemical binding]; other site 593907000098 activation loop (A-loop); other site 593907000099 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 593907000100 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 593907000101 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 593907000102 Active site [active] 593907000103 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 593907000104 phosphopeptide binding site; other site 593907000105 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 593907000106 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 593907000107 phosphopeptide binding site; other site 593907000108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 593907000109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907000110 dimer interface [polypeptide binding]; other site 593907000111 conserved gate region; other site 593907000112 putative PBP binding loops; other site 593907000113 ABC-ATPase subunit interface; other site 593907000114 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907000115 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907000116 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 593907000117 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 593907000118 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 593907000119 Walker A/P-loop; other site 593907000120 ATP binding site [chemical binding]; other site 593907000121 Q-loop/lid; other site 593907000122 ABC transporter signature motif; other site 593907000123 Walker B; other site 593907000124 D-loop; other site 593907000125 H-loop/switch region; other site 593907000126 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 593907000127 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 593907000128 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 593907000129 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 593907000130 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 593907000131 YcaO-like family; Region: YcaO; cl09146 593907000132 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 593907000133 M28, and M42; Region: Zinc_peptidase_like; cl14876 593907000134 metal binding site [ion binding]; metal-binding site 593907000135 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 593907000136 active site 593907000137 metal binding site [ion binding]; metal-binding site 593907000138 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 593907000139 Transcriptional regulators [Transcription]; Region: PurR; COG1609 593907000140 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 593907000141 DNA binding site [nucleotide binding] 593907000142 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 593907000143 dimerization interface [polypeptide binding]; other site 593907000144 ligand binding site [chemical binding]; other site 593907000145 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 593907000146 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 593907000147 metal binding site [ion binding]; metal-binding site 593907000148 ligand binding site [chemical binding]; other site 593907000149 Cupin domain; Region: Cupin_2; cl09118 593907000150 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 593907000151 Domain of unknown function DUF; Region: DUF202; cl09954 593907000152 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 593907000153 active site residue [active] 593907000154 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 593907000155 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 593907000156 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 593907000157 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 593907000158 active site residue [active] 593907000159 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 593907000160 putative homotetramer interface [polypeptide binding]; other site 593907000161 putative homodimer interface [polypeptide binding]; other site 593907000162 putative allosteric switch controlling residues; other site 593907000163 putative metal binding site [ion binding]; other site 593907000164 putative homodimer-homodimer interface [polypeptide binding]; other site 593907000165 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 593907000166 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 593907000167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 593907000168 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 593907000169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907000170 NAD(P) binding site [chemical binding]; other site 593907000171 active site 593907000172 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 593907000173 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 593907000174 methionine aminopeptidase; Reviewed; Region: PRK07281 593907000175 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 593907000176 active site 593907000177 YCII-related domain; Region: YCII; cl00999 593907000178 Fatty acid desaturase; Region: FA_desaturase; pfam00487 593907000179 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These...; Region: Delta6-FADS-like; cd03506 593907000180 putative di-iron ligands [ion binding]; other site 593907000181 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 593907000182 DNA-binding site [nucleotide binding]; DNA binding site 593907000183 RNA-binding motif; other site 593907000184 Low molecular weight phosphatase family; Region: LMWPc; cd00115 593907000185 Active site [active] 593907000186 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 593907000187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907000188 homodimer interface [polypeptide binding]; other site 593907000189 catalytic residue [active] 593907000190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3809 593907000191 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 593907000192 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 593907000193 ATP binding site [chemical binding]; other site 593907000194 substrate interface [chemical binding]; other site 593907000195 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 593907000196 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 593907000197 dimer interface [polypeptide binding]; other site 593907000198 putative functional site; other site 593907000199 putative MPT binding site; other site 593907000200 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the...; Region: MoaC; cl00242 593907000201 trimer interface [polypeptide binding]; other site 593907000202 dimer interface [polypeptide binding]; other site 593907000203 putative active site [active] 593907000204 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 593907000205 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 593907000206 FeS/SAM binding site; other site 593907000207 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 593907000208 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 593907000209 MoaE homodimer interface [polypeptide binding]; other site 593907000210 MoaD interaction [polypeptide binding]; other site 593907000211 active site residues [active] 593907000212 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 593907000213 MPT binding site; other site 593907000214 glycine dehydrogenase; Provisional; Region: PRK05367 593907000215 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 593907000216 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 593907000217 catalytic residue [active] 593907000218 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 593907000219 tetramer interface [polypeptide binding]; other site 593907000220 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907000221 catalytic residue [active] 593907000222 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 593907000223 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 593907000224 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 593907000225 lipoyl attachment site [posttranslational modification]; other site 593907000226 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 593907000227 DNA binding residues [nucleotide binding] 593907000228 dimerization interface [polypeptide binding]; other site 593907000229 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 593907000230 active site 593907000231 8-oxo-dGMP binding site [chemical binding]; other site 593907000232 nudix motif; other site 593907000233 metal binding site [ion binding]; metal-binding site 593907000234 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 593907000235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907000236 homodimer interface [polypeptide binding]; other site 593907000237 catalytic residue [active] 593907000238 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 593907000239 N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312 593907000240 THF binding site; other site 593907000241 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 593907000242 substrate binding site [chemical binding]; other site 593907000243 THF binding site; other site 593907000244 zinc-binding site [ion binding]; other site 593907000245 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 593907000246 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 593907000247 FAD binding site [chemical binding]; other site 593907000248 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 593907000249 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 593907000250 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 593907000251 ATP binding site [chemical binding]; other site 593907000252 putative Mg++ binding site [ion binding]; other site 593907000253 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 593907000254 Helicase associated domain (HA2); Region: HA2; cl04503 593907000255 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 593907000256 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 593907000257 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 593907000258 putative deacylase active site [active] 593907000259 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 593907000260 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 593907000261 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 593907000262 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 593907000263 active site 593907000264 metal binding site [ion binding]; metal-binding site 593907000265 DNA binding site [nucleotide binding] 593907000266 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 593907000267 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907000268 exonuclease subunit SbcC; Provisional; Region: PRK10246 593907000269 Walker A/P-loop; other site 593907000270 ATP binding site [chemical binding]; other site 593907000271 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907000272 ABC transporter signature motif; other site 593907000273 Walker B; other site 593907000274 D-loop; other site 593907000275 H-loop/switch region; other site 593907000276 Domain of unknown function (DUF1994); Region: DUF1994; pfam09352 593907000277 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333 593907000278 amphipathic channel; other site 593907000279 Asn-Pro-Ala signature motifs; other site 593907000280 Domain of unknown function (DUF385); Region: DUF385; cl04387 593907000281 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 593907000282 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 593907000283 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 593907000284 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 593907000285 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 593907000286 Walker A/P-loop; other site 593907000287 ATP binding site [chemical binding]; other site 593907000288 Q-loop/lid; other site 593907000289 ABC transporter signature motif; other site 593907000290 Walker B; other site 593907000291 D-loop; other site 593907000292 H-loop/switch region; other site 593907000293 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 593907000294 FtsX-like permease family; Region: FtsX; pfam02687 593907000295 FtsX-like permease family; Region: FtsX; pfam02687 593907000296 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 593907000297 active site 593907000298 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G_bact; cd04170 593907000299 elongation factor G; Reviewed; Region: PRK12740 593907000300 G1 box; other site 593907000301 putative GEF interaction site [polypeptide binding]; other site 593907000302 GTP/Mg2+ binding site [chemical binding]; other site 593907000303 Switch I region; other site 593907000304 G2 box; other site 593907000305 G3 box; other site 593907000306 Switch II region; other site 593907000307 G4 box; other site 593907000308 G5 box; other site 593907000309 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 593907000310 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 593907000311 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 593907000312 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 593907000313 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 593907000314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907000315 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 593907000316 diiron binding motif [ion binding]; other site 593907000317 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 593907000318 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 593907000319 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 593907000320 FAD binding pocket [chemical binding]; other site 593907000321 FAD binding motif [chemical binding]; other site 593907000322 phosphate binding motif [ion binding]; other site 593907000323 NAD binding pocket [chemical binding]; other site 593907000324 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 593907000325 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 593907000326 putative transposase OrfB; Reviewed; Region: PHA02517 593907000327 Integrase core domain; Region: rve; cl01316 593907000328 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 593907000329 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 593907000330 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 593907000331 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 593907000332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 593907000333 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 593907000334 Predicted membrane protein (DUF2078); Region: DUF2078; cl01373 593907000335 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 593907000336 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 593907000337 Walker A/P-loop; other site 593907000338 ATP binding site [chemical binding]; other site 593907000339 Q-loop/lid; other site 593907000340 ABC transporter signature motif; other site 593907000341 Walker B; other site 593907000342 D-loop; other site 593907000343 H-loop/switch region; other site 593907000344 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 593907000345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 593907000346 dimer interface [polypeptide binding]; other site 593907000347 phosphorylation site [posttranslational modification] 593907000348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 593907000349 ATP binding site [chemical binding]; other site 593907000350 Mg2+ binding site [ion binding]; other site 593907000351 G-X-G motif; other site 593907000352 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 593907000353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 593907000354 active site 593907000355 phosphorylation site [posttranslational modification] 593907000356 intermolecular recognition site; other site 593907000357 dimerization interface [polypeptide binding]; other site 593907000358 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 593907000359 DNA binding site [nucleotide binding] 593907000360 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 593907000361 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 593907000362 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 593907000363 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 593907000364 Domain of unknown function (DUF305); Region: DUF305; pfam03713 593907000365 Domain of unknown function (DUF305); Region: DUF305; pfam03713 593907000366 Integrase core domain; Region: rve; cl01316 593907000367 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 593907000368 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 593907000369 DNA binding residues [nucleotide binding] 593907000370 ANTAR domain; Region: ANTAR; pfam03861 593907000371 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 593907000372 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 593907000373 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 593907000374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907000375 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 593907000376 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 593907000377 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 593907000378 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 593907000379 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 593907000380 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; cl06815 593907000381 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 593907000382 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 593907000383 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 593907000384 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 593907000385 active site 593907000386 enterobactin exporter EntS; Provisional; Region: PRK10489 593907000387 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 593907000388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 593907000389 active site 593907000390 phosphorylation site [posttranslational modification] 593907000391 intermolecular recognition site; other site 593907000392 dimerization interface [polypeptide binding]; other site 593907000393 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 593907000394 DNA binding residues [nucleotide binding] 593907000395 dimerization interface [polypeptide binding]; other site 593907000396 Histidine kinase; Region: HisKA_3; pfam07730 593907000397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 593907000398 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 593907000399 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 593907000400 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 593907000401 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 593907000402 Integrase core domain; Region: rve; cl01316 593907000403 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 593907000404 active site 593907000405 substrate binding site [chemical binding]; other site 593907000406 ATP binding site [chemical binding]; other site 593907000407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 593907000408 Major Facilitator Superfamily; Region: MFS_1; pfam07690 593907000409 putative substrate translocation pore; other site 593907000410 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907000411 Transcriptional regulators [Transcription]; Region: PurR; COG1609 593907000412 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 593907000413 DNA binding site [nucleotide binding] 593907000414 domain linker motif; other site 593907000415 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 593907000416 putative dimerization interface [polypeptide binding]; other site 593907000417 putative ligand binding site [chemical binding]; other site 593907000418 phosphoglucomutase; Validated; Region: PRK07564 593907000419 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 593907000420 active site 593907000421 substrate binding site [chemical binding]; other site 593907000422 metal binding site [ion binding]; metal-binding site 593907000423 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 593907000424 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 593907000425 DNA binding site [nucleotide binding] 593907000426 active site 593907000427 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 593907000428 active site 593907000429 prephenate dehydratase; Provisional; Region: PRK11898 593907000430 Prephenate dehydratase; Region: PDT; pfam00800 593907000431 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 593907000432 putative L-Phe binding site [chemical binding]; other site 593907000433 Transcriptional regulators [Transcription]; Region: GntR; COG1802 593907000434 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 593907000435 DNA-binding site [nucleotide binding]; DNA binding site 593907000436 ATP-NAD kinase; Region: NAD_kinase; pfam01513 593907000437 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 593907000438 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 593907000439 seryl-tRNA synthetase; Provisional; Region: PRK05431 593907000440 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 593907000441 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 593907000442 dimer interface [polypeptide binding]; other site 593907000443 active site 593907000444 motif 1; other site 593907000445 motif 2; other site 593907000446 motif 3; other site 593907000447 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 593907000448 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 593907000449 active site 593907000450 motif I; other site 593907000451 motif II; other site 593907000452 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 593907000453 Transcriptional regulators [Transcription]; Region: PurR; COG1609 593907000454 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 593907000455 DNA binding site [nucleotide binding] 593907000456 domain linker motif; other site 593907000457 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 593907000458 dimerization interface [polypeptide binding]; other site 593907000459 ligand binding site [chemical binding]; other site 593907000460 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 593907000461 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907000462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907000463 dimer interface [polypeptide binding]; other site 593907000464 conserved gate region; other site 593907000465 putative PBP binding loops; other site 593907000466 ABC-ATPase subunit interface; other site 593907000467 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 593907000468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907000469 dimer interface [polypeptide binding]; other site 593907000470 conserved gate region; other site 593907000471 putative PBP binding loops; other site 593907000472 ABC-ATPase subunit interface; other site 593907000473 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 593907000474 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 593907000475 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 593907000476 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 593907000477 dimerization interface [polypeptide binding]; other site 593907000478 putative active cleft [active] 593907000479 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 593907000480 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 593907000481 NAD(P) binding site [chemical binding]; other site 593907000482 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 593907000483 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 593907000484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 593907000485 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 593907000486 Protein of unknown function (DUF742); Region: DUF742; pfam05331 593907000487 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 593907000488 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 593907000489 G1 box; other site 593907000490 GTP/Mg2+ binding site [chemical binding]; other site 593907000491 G2 box; other site 593907000492 Switch I region; other site 593907000493 G3 box; other site 593907000494 Switch II region; other site 593907000495 G4 box; other site 593907000496 G5 box; other site 593907000497 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047 593907000498 RNB domain; Region: RNB; pfam00773 593907000499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 593907000500 putative substrate translocation pore; other site 593907000501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 593907000502 SEC-C motif; Region: SEC-C; cl12132 593907000503 hypothetical protein; Provisional; Region: PRK04233 593907000504 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 593907000505 hydrophobic ligand binding site; other site 593907000506 Uncharacterized conserved protein [Function unknown]; Region: COG2966 593907000507 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 593907000508 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 593907000509 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 593907000510 dimer interface [polypeptide binding]; other site 593907000511 phosphorylation site [posttranslational modification] 593907000512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 593907000513 ATP binding site [chemical binding]; other site 593907000514 Mg2+ binding site [ion binding]; other site 593907000515 G-X-G motif; other site 593907000516 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 593907000517 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 593907000518 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 593907000519 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907000520 Walker A/P-loop; other site 593907000521 ATP binding site [chemical binding]; other site 593907000522 Q-loop/lid; other site 593907000523 ABC transporter signature motif; other site 593907000524 Walker B; other site 593907000525 D-loop; other site 593907000526 H-loop/switch region; other site 593907000527 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 593907000528 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 593907000529 non-specific DNA binding site [nucleotide binding]; other site 593907000530 salt bridge; other site 593907000531 sequence-specific DNA binding site [nucleotide binding]; other site 593907000532 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 593907000533 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 593907000534 putative active site [active] 593907000535 putative metal binding site [ion binding]; other site 593907000536 GatB domain; Region: GatB_Yqey; cl11497 593907000537 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 593907000538 DNA binding residues [nucleotide binding] 593907000539 TOBE domain; Region: TOBE_2; cl01440 593907000540 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907000541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907000542 putative PBP binding loops; other site 593907000543 ABC-ATPase subunit interface; other site 593907000544 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907000545 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 593907000546 Walker A/P-loop; other site 593907000547 ATP binding site [chemical binding]; other site 593907000548 Q-loop/lid; other site 593907000549 ABC transporter signature motif; other site 593907000550 Walker B; other site 593907000551 D-loop; other site 593907000552 H-loop/switch region; other site 593907000553 TOBE domain; Region: TOBE_2; cl01440 593907000554 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 593907000555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 593907000556 active site 593907000557 phosphorylation site [posttranslational modification] 593907000558 intermolecular recognition site; other site 593907000559 dimerization interface [polypeptide binding]; other site 593907000560 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 593907000561 DNA binding site [nucleotide binding] 593907000562 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 593907000563 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 593907000564 dimer interface [polypeptide binding]; other site 593907000565 phosphorylation site [posttranslational modification] 593907000566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 593907000567 MMPL family; Region: MMPL; pfam03176 593907000568 MMPL family; Region: MMPL; pfam03176 593907000569 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 593907000570 homodimer interface [polypeptide binding]; other site 593907000571 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 593907000572 active site pocket [active] 593907000573 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 593907000574 hydrophobic ligand binding site; other site 593907000575 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 593907000576 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 593907000577 Integrase core domain; Region: rve; cl01316 593907000578 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 593907000579 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 593907000580 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 593907000581 catalytic residues [active] 593907000582 catalytic nucleophile [active] 593907000583 Presynaptic Site I dimer interface [polypeptide binding]; other site 593907000584 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 593907000585 Synaptic Flat tetramer interface [polypeptide binding]; other site 593907000586 Synaptic Site I dimer interface [polypeptide binding]; other site 593907000587 DNA binding site [nucleotide binding] 593907000588 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 593907000589 DNA-binding interface [nucleotide binding]; DNA binding site 593907000590 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 593907000591 putative transposase OrfB; Reviewed; Region: PHA02517 593907000592 Integrase core domain; Region: rve; cl01316 593907000593 Cadmium resistance transporter; Region: Cad; cl04177 593907000594 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 593907000595 dimerization interface [polypeptide binding]; other site 593907000596 putative DNA binding site [nucleotide binding]; other site 593907000597 putative Zn2+ binding site [ion binding]; other site 593907000598 Cation efflux family; Region: Cation_efflux; cl00316 593907000599 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907000600 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 593907000601 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 593907000602 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 593907000603 putative active site [active] 593907000604 catalytic triad [active] 593907000605 putative dimer interface [polypeptide binding]; other site 593907000606 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 593907000607 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 593907000608 Domain of unknown function (DUF305); Region: DUF305; pfam03713 593907000609 Domain of unknown function (DUF305); Region: DUF305; pfam03713 593907000610 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 593907000611 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 593907000612 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 593907000613 catalytic residues [active] 593907000614 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 593907000615 dimerization interface [polypeptide binding]; other site 593907000616 putative DNA binding site [nucleotide binding]; other site 593907000617 putative Zn2+ binding site [ion binding]; other site 593907000618 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 593907000619 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 593907000620 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 593907000621 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 593907000622 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 593907000623 dimerization interface [polypeptide binding]; other site 593907000624 putative DNA binding site [nucleotide binding]; other site 593907000625 putative Zn2+ binding site [ion binding]; other site 593907000626 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 593907000627 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 593907000628 putative NAD(P) binding site [chemical binding]; other site 593907000629 Cupin domain; Region: Cupin_2; cl09118 593907000630 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 593907000631 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 593907000632 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 593907000633 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 593907000634 putative transposase OrfB; Reviewed; Region: PHA02517 593907000635 Integrase core domain; Region: rve; cl01316 593907000636 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 593907000637 putative transposase OrfB; Reviewed; Region: PHA02517 593907000638 Integrase core domain; Region: rve; cl01316 593907000639 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 593907000640 DNA binding residues [nucleotide binding] 593907000641 dimer interface [polypeptide binding]; other site 593907000642 metal binding site [ion binding]; metal-binding site 593907000643 Cadmium resistance transporter; Region: Cad; cl04177 593907000644 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 593907000645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 593907000646 S-adenosylmethionine binding site [chemical binding]; other site 593907000647 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 593907000648 dimerization interface [polypeptide binding]; other site 593907000649 putative DNA binding site [nucleotide binding]; other site 593907000650 putative Zn2+ binding site [ion binding]; other site 593907000651 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 593907000652 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 593907000653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 593907000654 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 593907000655 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 593907000656 catalytic residues [active] 593907000657 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 593907000658 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 593907000659 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 593907000660 Ycf48-like protein; Provisional; Region: PRK13684 593907000661 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 593907000662 multiple promoter invertase; Provisional; Region: mpi; PRK13413 593907000663 catalytic residues [active] 593907000664 catalytic nucleophile [active] 593907000665 Presynaptic Site I dimer interface [polypeptide binding]; other site 593907000666 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 593907000667 Synaptic Flat tetramer interface [polypeptide binding]; other site 593907000668 Synaptic Site I dimer interface [polypeptide binding]; other site 593907000669 DNA binding site [nucleotide binding] 593907000670 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 593907000671 DNA-binding interface [nucleotide binding]; DNA binding site 593907000672 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 593907000673 DNA binding residues [nucleotide binding] 593907000674 putative dimer interface [polypeptide binding]; other site 593907000675 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 593907000676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 593907000677 S-adenosylmethionine binding site [chemical binding]; other site 593907000678 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 593907000679 catalytic triad [active] 593907000680 active site 593907000681 oxyanion hole [active] 593907000682 Cellulose binding domain; Region: CBM_2; cl02709 593907000683 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 593907000684 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 593907000685 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 593907000686 catalytic core [active] 593907000687 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 593907000688 Clp amino terminal domain; Region: Clp_N; pfam02861 593907000689 Clp amino terminal domain; Region: Clp_N; pfam02861 593907000690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 593907000691 Walker A motif; other site 593907000692 ATP binding site [chemical binding]; other site 593907000693 Walker B motif; other site 593907000694 arginine finger; other site 593907000695 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 593907000696 Walker A motif; other site 593907000697 ATP binding site [chemical binding]; other site 593907000698 Walker B motif; other site 593907000699 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 593907000700 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 593907000701 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 593907000702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907000703 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 593907000704 putative phosphate binding site [ion binding]; other site 593907000705 putative catalytic site [active] 593907000706 active site 593907000707 metal binding site A [ion binding]; metal-binding site 593907000708 DNA binding site [nucleotide binding] 593907000709 putative AP binding site [nucleotide binding]; other site 593907000710 putative metal binding site B [ion binding]; other site 593907000711 glycerol kinase; Provisional; Region: glpK; PRK00047 593907000712 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 593907000713 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 593907000714 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cl00200 593907000715 amphipathic channel; other site 593907000716 Asn-Pro-Ala signature motifs; other site 593907000717 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 593907000718 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 593907000719 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 593907000720 DNA binding residues [nucleotide binding] 593907000721 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 593907000722 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907000723 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 593907000724 minor groove reading motif; other site 593907000725 helix-hairpin-helix signature motif; other site 593907000726 active site 593907000727 FES domain; Region: FES; smart00525 593907000728 Phd_YefM; Region: PhdYeFM; cl09153 593907000729 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 593907000730 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 593907000731 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 593907000732 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 593907000733 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 593907000734 DNA repair protein RadA; Provisional; Region: PRK11823 593907000735 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907000736 Walker A motif; other site 593907000737 ATP binding site [chemical binding]; other site 593907000738 Walker B motif; other site 593907000739 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 593907000740 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 593907000741 Walker A/P-loop; other site 593907000742 ATP binding site [chemical binding]; other site 593907000743 Q-loop/lid; other site 593907000744 ABC transporter signature motif; other site 593907000745 Walker B; other site 593907000746 D-loop; other site 593907000747 H-loop/switch region; other site 593907000748 ABC-2 type transporter; Region: ABC2_membrane; cl11417 593907000749 ABC-2 type transporter; Region: ABC2_membrane; cl11417 593907000750 ATP synthase; Region: ATP-synt; cl00365 593907000751 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 593907000752 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 593907000753 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 593907000754 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 593907000755 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 593907000756 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 593907000757 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 593907000758 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 593907000759 substrate binding site [chemical binding]; other site 593907000760 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 593907000761 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 593907000762 Walker A/P-loop; other site 593907000763 ATP binding site [chemical binding]; other site 593907000764 Q-loop/lid; other site 593907000765 ABC transporter signature motif; other site 593907000766 Walker B; other site 593907000767 D-loop; other site 593907000768 H-loop/switch region; other site 593907000769 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 593907000770 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 593907000771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907000772 dimer interface [polypeptide binding]; other site 593907000773 conserved gate region; other site 593907000774 putative PBP binding loops; other site 593907000775 ABC-ATPase subunit interface; other site 593907000776 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 593907000777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907000778 dimer interface [polypeptide binding]; other site 593907000779 conserved gate region; other site 593907000780 putative PBP binding loops; other site 593907000781 ABC-ATPase subunit interface; other site 593907000782 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 593907000783 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 593907000784 Walker A/P-loop; other site 593907000785 ATP binding site [chemical binding]; other site 593907000786 Q-loop/lid; other site 593907000787 ABC transporter signature motif; other site 593907000788 Walker B; other site 593907000789 D-loop; other site 593907000790 H-loop/switch region; other site 593907000791 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 593907000792 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 593907000793 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 593907000794 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 593907000795 active site 593907000796 interdomain interaction site; other site 593907000797 putative metal-binding site [ion binding]; other site 593907000798 nucleotide binding site [chemical binding]; other site 593907000799 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cl11986 593907000800 domain I; other site 593907000801 phosphate binding site [ion binding]; other site 593907000802 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 593907000803 domain II; other site 593907000804 domain III; other site 593907000805 nucleotide binding site [chemical binding]; other site 593907000806 DNA binding groove [nucleotide binding] 593907000807 catalytic site [active] 593907000808 domain IV; other site 593907000809 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 593907000810 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 593907000811 Immunoglobulin domain; Region: Ig; cl11960 593907000812 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 593907000813 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907000814 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 593907000815 thymidylate kinase; Validated; Region: tmk; PRK00698 593907000816 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 593907000817 TMP-binding site; other site 593907000818 ATP-binding site [chemical binding]; other site 593907000819 DNA polymerase III subunit delta'; Validated; Region: PRK07940 593907000820 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 593907000821 Walker A motif; other site 593907000822 ATP binding site [chemical binding]; other site 593907000823 Walker B motif; other site 593907000824 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907000825 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 593907000826 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 593907000827 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 593907000828 active site 593907000829 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 593907000830 active site 593907000831 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 593907000832 nucleotide binding site [chemical binding]; other site 593907000833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 593907000834 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 593907000835 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 593907000836 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 593907000837 5'-3' exonuclease; Region: 53EXOc; smart00475 593907000838 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 593907000839 active site 593907000840 metal binding site 1 [ion binding]; metal-binding site 593907000841 putative 5' ssDNA interaction site; other site 593907000842 metal binding site 3; metal-binding site 593907000843 metal binding site 2 [ion binding]; metal-binding site 593907000844 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 593907000845 putative DNA binding site [nucleotide binding]; other site 593907000846 putative metal binding site [ion binding]; other site 593907000847 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 593907000848 putative active site [active] 593907000849 catalytic triad [active] 593907000850 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain...; Region: PA; cl08238 593907000851 PA/protease or protease-like domain interface [polypeptide binding]; other site 593907000852 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 593907000853 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 593907000854 OsmC-like protein; Region: OsmC; cl00767 593907000855 FeoA domain; Region: FeoA; cl00838 593907000856 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 593907000857 G1 box; other site 593907000858 GTP/Mg2+ binding site [chemical binding]; other site 593907000859 G2 box; other site 593907000860 Switch I region; other site 593907000861 G3 box; other site 593907000862 Switch II region; other site 593907000863 G4 box; other site 593907000864 G5 box; other site 593907000865 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 593907000866 Nucleoside recognition; Region: Gate; cl00486 593907000867 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 593907000868 FAD binding domain; Region: FAD_binding_4; pfam01565 593907000869 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 593907000870 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 593907000871 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 593907000872 Domain of unknown function DUF77; Region: DUF77; cl00307 593907000873 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 593907000874 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 593907000875 Protein of unknown function (DUF1749); Region: DUF1749; pfam08538 593907000876 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 593907000877 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 593907000878 NAD(P) binding site [chemical binding]; other site 593907000879 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 593907000880 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 593907000881 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 593907000882 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 593907000883 homodimer interface [polypeptide binding]; other site 593907000884 substrate-cofactor binding pocket; other site 593907000885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907000886 catalytic residue [active] 593907000887 NlpC/P60 family; Region: NLPC_P60; cl11438 593907000888 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 593907000889 dimer interface [polypeptide binding]; other site 593907000890 substrate binding site [chemical binding]; other site 593907000891 metal binding sites [ion binding]; metal-binding site 593907000892 PBP4 family; Region: PBP4; TIGR00666 593907000893 Beta-lactamase; Region: Beta-lactamase; cl01009 593907000894 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 593907000895 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 593907000896 Ligand Binding Site [chemical binding]; other site 593907000897 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 593907000898 FtsH Extracellular; Region: FtsH_ext; pfam06480 593907000899 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 593907000900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 593907000901 Walker A motif; other site 593907000902 ATP binding site [chemical binding]; other site 593907000903 Walker B motif; other site 593907000904 arginine finger; other site 593907000905 Peptidase family M41; Region: Peptidase_M41; pfam01434 593907000906 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 593907000907 homodecamer interface [polypeptide binding]; other site 593907000908 GTP cyclohydrolase I; Provisional; Region: PLN03044 593907000909 active site 593907000910 putative catalytic site residues [active] 593907000911 zinc binding site [ion binding]; other site 593907000912 GTP-CH-I/GFRP interaction surface; other site 593907000913 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 593907000914 putative acyl-acceptor binding pocket; other site 593907000915 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 593907000916 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 593907000917 Pterin binding enzyme; Region: Pterin_bind; pfam00809 593907000918 substrate binding pocket [chemical binding]; other site 593907000919 inhibitor binding site; inhibition site 593907000920 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534 593907000921 homooctamer interface [polypeptide binding]; other site 593907000922 active site 593907000923 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 593907000924 catalytic center binding site [active] 593907000925 ATP binding site [chemical binding]; other site 593907000926 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 593907000927 Bacterial membrane flanked domain; Region: DUF304; cl01348 593907000928 Predicted membrane protein [Function unknown]; Region: COG3428 593907000929 Bacterial membrane flanked domain; Region: DUF304; cl01348 593907000930 Bacterial membrane flanked domain; Region: DUF304; cl01348 593907000931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907000932 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 593907000933 pantoate--beta-alanine ligase; Region: panC; TIGR00018 593907000934 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 593907000935 active site 593907000936 nucleotide binding site [chemical binding]; other site 593907000937 HIGH motif; other site 593907000938 KMSKS motif; other site 593907000939 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 593907000940 tetramerization interface [polypeptide binding]; other site 593907000941 active site 593907000942 L-aspartate oxidase; Provisional; Region: PRK07804 593907000943 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 593907000944 domain; Region: Succ_DH_flav_C; pfam02910 593907000945 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 593907000946 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 593907000947 dimerization interface [polypeptide binding]; other site 593907000948 active site 593907000949 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 593907000950 Integrase core domain; Region: rve; cl01316 593907000951 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 593907000952 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 593907000953 DNA binding residues [nucleotide binding] 593907000954 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 593907000955 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 593907000956 dimer interface [polypeptide binding]; other site 593907000957 putative anticodon binding site; other site 593907000958 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 593907000959 motif 1; other site 593907000960 dimer interface [polypeptide binding]; other site 593907000961 active site 593907000962 motif 2; other site 593907000963 motif 3; other site 593907000964 Lsr2; Region: Lsr2; pfam11774 593907000965 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 593907000966 D-xylulose kinase; Region: XylB; TIGR01312 593907000967 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 593907000968 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 593907000969 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 593907000970 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 593907000971 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 593907000972 TM1410 hypothetical-related protein; Region: DUF297; cl00997 593907000973 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 593907000974 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 593907000975 putative ADP-binding pocket [chemical binding]; other site 593907000976 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 593907000977 catalytic core [active] 593907000978 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 593907000979 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 593907000980 PhoU domain; Region: PhoU; pfam01895 593907000981 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 593907000982 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 593907000983 dimer interface [polypeptide binding]; other site 593907000984 phosphorylation site [posttranslational modification] 593907000985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 593907000986 ATP binding site [chemical binding]; other site 593907000987 Mg2+ binding site [ion binding]; other site 593907000988 G-X-G motif; other site 593907000989 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 593907000990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 593907000991 active site 593907000992 phosphorylation site [posttranslational modification] 593907000993 intermolecular recognition site; other site 593907000994 dimerization interface [polypeptide binding]; other site 593907000995 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 593907000996 DNA binding site [nucleotide binding] 593907000997 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907000998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907000999 dimer interface [polypeptide binding]; other site 593907001000 conserved gate region; other site 593907001001 putative PBP binding loops; other site 593907001002 ABC-ATPase subunit interface; other site 593907001003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907001004 dimer interface [polypeptide binding]; other site 593907001005 conserved gate region; other site 593907001006 putative PBP binding loops; other site 593907001007 ABC-ATPase subunit interface; other site 593907001008 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 593907001009 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 593907001010 Walker A/P-loop; other site 593907001011 ATP binding site [chemical binding]; other site 593907001012 Q-loop/lid; other site 593907001013 ABC transporter signature motif; other site 593907001014 Walker B; other site 593907001015 D-loop; other site 593907001016 H-loop/switch region; other site 593907001017 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 593907001018 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 593907001019 active site 593907001020 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cl10030 593907001021 homotrimer interaction site [polypeptide binding]; other site 593907001022 zinc binding site [ion binding]; other site 593907001023 CDP-binding sites; other site 593907001024 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 593907001025 Transcriptional regulator [Transcription]; Region: LysR; COG0583 593907001026 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907001027 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 593907001028 dimerization interface [polypeptide binding]; other site 593907001029 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 593907001030 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 593907001031 putative NAD(P) binding site [chemical binding]; other site 593907001032 sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678 593907001033 FAD binding domain; Region: FAD_binding_4; pfam01565 593907001034 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 593907001035 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 593907001036 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 593907001037 catalytic residue [active] 593907001038 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 593907001039 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 593907001040 active site 593907001041 HIGH motif; other site 593907001042 nucleotide binding site [chemical binding]; other site 593907001043 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 593907001044 KMSKS motif; other site 593907001045 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 593907001046 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 593907001047 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 593907001048 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 593907001049 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 593907001050 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 593907001051 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 593907001052 Walker A/P-loop; other site 593907001053 ATP binding site [chemical binding]; other site 593907001054 Q-loop/lid; other site 593907001055 ABC transporter signature motif; other site 593907001056 Walker B; other site 593907001057 D-loop; other site 593907001058 H-loop/switch region; other site 593907001059 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 593907001060 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 593907001061 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 593907001062 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is...; Region: GT1_TPS; cd03788 593907001063 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 593907001064 active site 593907001065 homotetramer interface [polypeptide binding]; other site 593907001066 Protein kinase domain; Region: Pkinase; pfam00069 593907001067 Catalytic domain of Protein Kinases; Region: PKc; cd00180 593907001068 active site 593907001069 ATP binding site [chemical binding]; other site 593907001070 substrate binding site [chemical binding]; other site 593907001071 activation loop (A-loop); other site 593907001072 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 593907001073 catalytic residues [active] 593907001074 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 593907001075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 593907001076 active site 593907001077 phosphorylation site [posttranslational modification] 593907001078 intermolecular recognition site; other site 593907001079 dimerization interface [polypeptide binding]; other site 593907001080 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 593907001081 DNA binding residues [nucleotide binding] 593907001082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 593907001083 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 593907001084 Catalytic site [active] 593907001085 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 593907001086 active site 593907001087 catalytic triad [active] 593907001088 oxyanion hole [active] 593907001089 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 593907001090 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 593907001091 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 593907001092 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 593907001093 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 593907001094 ring oligomerisation interface [polypeptide binding]; other site 593907001095 ATP/Mg binding site [chemical binding]; other site 593907001096 stacking interactions; other site 593907001097 hinge regions; other site 593907001098 Protein of unknown function (DUF541); Region: SIMPL; cl01077 593907001099 tyrosine aminotransferase, eukaryotic; Region: tyr_amTase_E; TIGR01264 593907001100 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 593907001101 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907001102 homodimer interface [polypeptide binding]; other site 593907001103 catalytic residue [active] 593907001104 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 593907001105 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 593907001106 dimerization interface [polypeptide binding]; other site 593907001107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 593907001108 dimer interface [polypeptide binding]; other site 593907001109 phosphorylation site [posttranslational modification] 593907001110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 593907001111 ATP binding site [chemical binding]; other site 593907001112 Mg2+ binding site [ion binding]; other site 593907001113 G-X-G motif; other site 593907001114 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 593907001115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 593907001116 active site 593907001117 phosphorylation site [posttranslational modification] 593907001118 intermolecular recognition site; other site 593907001119 dimerization interface [polypeptide binding]; other site 593907001120 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 593907001121 DNA binding site [nucleotide binding] 593907001122 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 593907001123 catalytic triad [active] 593907001124 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 593907001125 DNA repair helicase rad25; Region: rad25; TIGR00603 593907001126 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 593907001127 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 593907001128 ATP binding site [chemical binding]; other site 593907001129 putative Mg++ binding site [ion binding]; other site 593907001130 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 593907001131 nucleotide binding region [chemical binding]; other site 593907001132 ATP-binding site [chemical binding]; other site 593907001133 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 593907001134 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 593907001135 metal binding site [ion binding]; metal-binding site 593907001136 dimer interface [polypeptide binding]; other site 593907001137 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 593907001138 DNA-binding site [nucleotide binding]; DNA binding site 593907001139 RNA-binding motif; other site 593907001140 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 593907001141 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 593907001142 DNA binding residues [nucleotide binding] 593907001143 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 593907001144 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 593907001145 FliW protein; Region: FliW; cl00740 593907001146 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 593907001147 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 593907001148 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 593907001149 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 593907001150 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 593907001151 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 593907001152 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 593907001153 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 593907001154 DNA binding residues [nucleotide binding] 593907001155 flagellin; Reviewed; Region: PRK08869 593907001156 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 593907001157 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 593907001158 flagellar capping protein; Reviewed; Region: fliD; PRK08032 593907001159 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 593907001160 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 593907001161 Flagellar protein FliS; Region: FliS; cl00654 593907001162 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 593907001163 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 593907001164 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 593907001165 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 593907001166 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 593907001167 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 593907001168 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 593907001169 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 593907001170 FliG C-terminal domain; Region: FliG_C; pfam01706 593907001171 Flagellar assembly protein FliH; Region: FliH; pfam02108 593907001172 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 593907001173 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 593907001174 Walker A motif/ATP binding site; other site 593907001175 Walker B motif; other site 593907001176 Flagellar FliJ protein; Region: FliJ; cl09161 593907001177 NlpC/P60 family; Region: NLPC_P60; cl11438 593907001178 Flagellar hook capping protein; Region: FlgD; cl04347 593907001179 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 593907001180 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 593907001181 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 593907001182 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 593907001183 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 593907001184 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 593907001185 PAS fold; Region: PAS_3; pfam08447 593907001186 putative active site [active] 593907001187 heme pocket [chemical binding]; other site 593907001188 PAS fold; Region: PAS_4; pfam08448 593907001189 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 593907001190 putative active site [active] 593907001191 heme pocket [chemical binding]; other site 593907001192 GAF domain; Region: GAF; cl00853 593907001193 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 593907001194 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 593907001195 DEAD-like helicases superfamily; Region: DEXDc; smart00487 593907001196 ATP binding site [chemical binding]; other site 593907001197 putative Mg++ binding site [ion binding]; other site 593907001198 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 593907001199 nucleotide binding region [chemical binding]; other site 593907001200 ATP-binding site [chemical binding]; other site 593907001201 Flagellar protein (FlbD); Region: FlbD; cl00683 593907001202 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 593907001203 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 593907001204 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 593907001205 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 593907001206 ligand binding site [chemical binding]; other site 593907001207 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 593907001208 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 593907001209 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 593907001210 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 593907001211 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 593907001212 FliP family; Region: FliP; cl00593 593907001213 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 593907001214 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 593907001215 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 593907001216 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 593907001217 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 593907001218 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 593907001219 Global regulator protein family; Region: CsrA; cl00670 593907001220 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 593907001221 putative binding surface; other site 593907001222 active site 593907001223 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 593907001224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 593907001225 ATP binding site [chemical binding]; other site 593907001226 Mg2+ binding site [ion binding]; other site 593907001227 G-X-G motif; other site 593907001228 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 593907001229 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 593907001230 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 593907001231 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 593907001232 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 593907001233 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 593907001234 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 593907001235 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 593907001236 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 593907001237 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 593907001238 putative ligand binding site [chemical binding]; other site 593907001239 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 593907001240 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 593907001241 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 593907001242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 593907001243 active site 593907001244 phosphorylation site [posttranslational modification] 593907001245 intermolecular recognition site; other site 593907001246 dimerization interface [polypeptide binding]; other site 593907001247 CheB methylesterase; Region: CheB_methylest; pfam01339 593907001248 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 593907001249 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 593907001250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 593907001251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 593907001252 Response regulator receiver domain; Region: Response_reg; pfam00072 593907001253 active site 593907001254 phosphorylation site [posttranslational modification] 593907001255 intermolecular recognition site; other site 593907001256 dimerization interface [polypeptide binding]; other site 593907001257 Response regulator receiver domain; Region: Response_reg; pfam00072 593907001258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 593907001259 active site 593907001260 phosphorylation site [posttranslational modification] 593907001261 intermolecular recognition site; other site 593907001262 dimerization interface [polypeptide binding]; other site 593907001263 Sulfate transporter family; Region: Sulfate_transp; cl00967 593907001264 Permease family; Region: Xan_ur_permease; pfam00860 593907001265 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 593907001266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907001267 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 593907001268 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 593907001269 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907001270 H+ Antiporter protein; Region: 2A0121; TIGR00900 593907001271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 593907001272 putative substrate translocation pore; other site 593907001273 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 593907001274 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 593907001275 catalytic residue [active] 593907001276 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907001277 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 593907001278 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 593907001279 FeoA domain; Region: FeoA; cl00838 593907001280 NlpC/P60 family; Region: NLPC_P60; cl11438 593907001281 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 593907001282 active site 593907001283 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 593907001284 Ligand Binding Site [chemical binding]; other site 593907001285 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 593907001286 Ligand Binding Site [chemical binding]; other site 593907001287 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 593907001288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907001289 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 593907001290 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 593907001291 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 593907001292 inhibitor-cofactor binding pocket; inhibition site 593907001293 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907001294 catalytic residue [active] 593907001295 Amidinotransferase; Region: Amidinotransf; cl12043 593907001296 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 593907001297 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 593907001298 hydrophobic ligand binding site; other site 593907001299 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 593907001300 active site 593907001301 catalytic tetrad [active] 593907001302 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 593907001303 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 593907001304 active site 593907001305 catalytic site [active] 593907001306 substrate binding site [chemical binding]; other site 593907001307 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cl00038 593907001308 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 593907001309 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 593907001310 OsmC-like protein; Region: OsmC; cl00767 593907001311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907001312 short chain dehydrogenase; Provisional; Region: PRK06701 593907001313 NAD(P) binding site [chemical binding]; other site 593907001314 active site 593907001315 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 593907001316 DNA binding residues [nucleotide binding] 593907001317 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 593907001318 Phage integrase family; Region: Phage_integrase; pfam00589 593907001319 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 593907001320 DNA binding site [nucleotide binding] 593907001321 Int/Topo IB signature motif; other site 593907001322 active site 593907001323 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 593907001324 TrwC relaxase; Region: TrwC; cl08490 593907001325 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 593907001326 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 593907001327 putative transposase OrfB; Reviewed; Region: PHA02517 593907001328 Integrase core domain; Region: rve; cl01316 593907001329 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 593907001330 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 593907001331 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 593907001332 Walker A/P-loop; other site 593907001333 ATP binding site [chemical binding]; other site 593907001334 Q-loop/lid; other site 593907001335 ABC transporter signature motif; other site 593907001336 Walker B; other site 593907001337 D-loop; other site 593907001338 H-loop/switch region; other site 593907001339 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 593907001340 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 593907001341 nudix motif; other site 593907001342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 593907001343 S-adenosylmethionine binding site [chemical binding]; other site 593907001344 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 593907001345 ATP binding site [chemical binding]; other site 593907001346 putative Mg++ binding site [ion binding]; other site 593907001347 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 593907001348 nucleotide binding region [chemical binding]; other site 593907001349 ATP-binding site [chemical binding]; other site 593907001350 Nuclease-related domain; Region: NERD; pfam08378 593907001351 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 593907001352 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 593907001353 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 593907001354 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 593907001355 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 593907001356 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 593907001357 YibE/F-like protein; Region: YibE_F; cl02259 593907001358 YibE/F-like protein; Region: YibE_F; cl02259 593907001359 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 593907001360 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 593907001361 active site 593907001362 catalytic tetrad [active] 593907001363 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 593907001364 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 593907001365 active site 593907001366 catalytic tetrad [active] 593907001367 Transcriptional regulator [Transcription]; Region: LysR; COG0583 593907001368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907001369 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 593907001370 putative dimerization interface [polypeptide binding]; other site 593907001371 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 593907001372 SAF domain; Region: SAF; cl00555 593907001373 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 593907001374 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 593907001375 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 593907001376 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-...; Region: Ntn_PGA_like; cd03747 593907001377 active site 593907001378 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 593907001379 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 593907001380 active site 593907001381 tetramer interface [polypeptide binding]; other site 593907001382 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 593907001383 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 593907001384 dimer interface [polypeptide binding]; other site 593907001385 putative functional site; other site 593907001386 putative MPT binding site; other site 593907001387 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 593907001388 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907001389 Membrane transport protein; Region: Mem_trans; cl09117 593907001390 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 593907001391 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within...; Region: GH20_SpHex_like; cd06568 593907001392 active site 593907001393 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 593907001394 Predicted methyltransferases [General function prediction only]; Region: COG0313 593907001395 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 593907001396 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 593907001397 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 593907001398 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907001399 Walker A/P-loop; other site 593907001400 ATP binding site [chemical binding]; other site 593907001401 Q-loop/lid; other site 593907001402 ABC transporter signature motif; other site 593907001403 Walker B; other site 593907001404 D-loop; other site 593907001405 H-loop/switch region; other site 593907001406 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 593907001407 catalytic triad [active] 593907001408 conserved cis-peptide bond; other site 593907001409 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 593907001410 Ycf48-like protein; Provisional; Region: PRK13684 593907001411 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 593907001412 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 593907001413 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 593907001414 active site 593907001415 HIGH motif; other site 593907001416 KMSKS motif; other site 593907001417 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 593907001418 tRNA binding surface [nucleotide binding]; other site 593907001419 anticodon binding site; other site 593907001420 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 593907001421 active site 593907001422 Domain of unknown function (DUF348); Region: DUF348; pfam03990 593907001423 Domain of unknown function (DUF348); Region: DUF348; pfam03990 593907001424 G5 domain; Region: G5; pfam07501 593907001425 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 593907001426 N-acetyl-D-glucosamine binding site [chemical binding]; other site 593907001427 catalytic residue [active] 593907001428 Domain of unknown function (DUF348); Region: DUF348; pfam03990 593907001429 Domain of unknown function (DUF348); Region: DUF348; pfam03990 593907001430 G5 domain; Region: G5; pfam07501 593907001431 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 593907001432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 593907001433 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 593907001434 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 593907001435 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 593907001436 ABC transporter; Region: ABC_tran_2; pfam12848 593907001437 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907001438 Walker A/P-loop; other site 593907001439 ATP binding site [chemical binding]; other site 593907001440 Q-loop/lid; other site 593907001441 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907001442 Walker B; other site 593907001443 D-loop; other site 593907001444 H-loop/switch region; other site 593907001445 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907001446 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 593907001447 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 593907001448 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 593907001449 RNA/DNA hybrid binding site [nucleotide binding]; other site 593907001450 active site 593907001451 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 593907001452 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907001453 Walker A/P-loop; other site 593907001454 ATP binding site [chemical binding]; other site 593907001455 Q-loop/lid; other site 593907001456 ABC transporter signature motif; other site 593907001457 Walker B; other site 593907001458 D-loop; other site 593907001459 H-loop/switch region; other site 593907001460 Transcriptional regulators [Transcription]; Region: MarR; COG1846 593907001461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907001462 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 593907001463 active site 593907001464 metal binding site [ion binding]; metal-binding site 593907001465 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 593907001466 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 593907001467 Substrate binding site [chemical binding]; other site 593907001468 Mg++ binding site [ion binding]; other site 593907001469 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 593907001470 active site 593907001471 substrate binding site [chemical binding]; other site 593907001472 CoA binding site [chemical binding]; other site 593907001473 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 593907001474 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 593907001475 Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495 593907001476 5S rRNA interface [nucleotide binding]; other site 593907001477 CTC domain interface; other site 593907001478 L16 interface [polypeptide binding]; other site 593907001479 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 593907001480 putative active site [active] 593907001481 catalytic residue [active] 593907001482 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 593907001483 Bacterial sugar transferase; Region: Bac_transf; cl00939 593907001484 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 593907001485 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 593907001486 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 593907001487 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 593907001488 active site 593907001489 nucleotide binding site [chemical binding]; other site 593907001490 HIGH motif; other site 593907001491 KMSKS motif; other site 593907001492 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 593907001493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907001494 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 593907001495 Chain length determinant protein; Region: Wzz; cl01623 593907001496 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 593907001497 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 593907001498 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 593907001499 active site 593907001500 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 593907001501 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 593907001502 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 593907001503 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 593907001504 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 593907001505 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 593907001506 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 593907001507 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 593907001508 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 593907001509 ATP binding site [chemical binding]; other site 593907001510 putative Mg++ binding site [ion binding]; other site 593907001511 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 593907001512 nucleotide binding region [chemical binding]; other site 593907001513 ATP-binding site [chemical binding]; other site 593907001514 TRCF domain; Region: TRCF; pfam03461 593907001515 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 593907001516 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 593907001517 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907001518 NAD(P) binding site [chemical binding]; other site 593907001519 active site 593907001520 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 593907001521 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907001522 Walker A/P-loop; other site 593907001523 ATP binding site [chemical binding]; other site 593907001524 Q-loop/lid; other site 593907001525 ABC transporter signature motif; other site 593907001526 Walker B; other site 593907001527 D-loop; other site 593907001528 H-loop/switch region; other site 593907001529 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 593907001530 malate synthase A; Region: malate_syn_A; TIGR01344 593907001531 active site 593907001532 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 593907001533 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 593907001534 tetramer interface [polypeptide binding]; other site 593907001535 active site 593907001536 Mg2+/Mn2+ binding site [ion binding]; other site 593907001537 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 593907001538 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 593907001539 non-specific DNA binding site [nucleotide binding]; other site 593907001540 salt bridge; other site 593907001541 sequence-specific DNA binding site [nucleotide binding]; other site 593907001542 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 593907001543 Domain of unknown function (DUF955); Region: DUF955; cl01076 593907001544 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 593907001545 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 593907001546 active site 593907001547 substrate-binding site [chemical binding]; other site 593907001548 metal-binding site [ion binding] 593907001549 GTP binding site [chemical binding]; other site 593907001550 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 593907001551 non-specific DNA binding site [nucleotide binding]; other site 593907001552 salt bridge; other site 593907001553 sequence-specific DNA binding site [nucleotide binding]; other site 593907001554 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 593907001555 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 593907001556 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 593907001557 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 593907001558 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 593907001559 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 593907001560 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 593907001561 Cellulose binding domain; Region: CBM_2; cl02709 593907001562 enolase; Provisional; Region: eno; PRK00077 593907001563 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 593907001564 dimer interface [polypeptide binding]; other site 593907001565 metal binding site [ion binding]; metal-binding site 593907001566 substrate binding pocket [chemical binding]; other site 593907001567 Septum formation initiator; Region: DivIC; cl11433 593907001568 Protein of unknown function (DUF501); Region: DUF501; cl00652 593907001569 exopolyphosphatase; Region: exo_poly_only; TIGR03706 593907001570 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 593907001571 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 593907001572 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 593907001573 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 593907001574 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907001575 haloalkane dehalogenase; Provisional; Region: PRK03204 593907001576 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 593907001577 FAD binding pocket [chemical binding]; other site 593907001578 FAD binding motif [chemical binding]; other site 593907001579 phosphate binding motif [ion binding]; other site 593907001580 NAD binding pocket [chemical binding]; other site 593907001581 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907001582 ABC-2 type transporter; Region: ABC2_membrane; cl11417 593907001583 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 593907001584 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 593907001585 Walker A/P-loop; other site 593907001586 ATP binding site [chemical binding]; other site 593907001587 Q-loop/lid; other site 593907001588 ABC transporter signature motif; other site 593907001589 Walker B; other site 593907001590 D-loop; other site 593907001591 H-loop/switch region; other site 593907001592 BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cl00473 593907001593 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 593907001594 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 593907001595 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 593907001596 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 593907001597 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 593907001598 putative metal binding site [ion binding]; other site 593907001599 Integral membrane protein TerC family; Region: TerC; cl10468 593907001600 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 593907001601 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 593907001602 putative metal binding site [ion binding]; other site 593907001603 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 593907001604 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 593907001605 putative metal binding site [ion binding]; other site 593907001606 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 593907001607 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 593907001608 putative metal binding site [ion binding]; other site 593907001609 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 593907001610 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 593907001611 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 593907001612 Rdx family; Region: Rdx; cl01407 593907001613 Abi-like protein; Region: Abi_2; cl01988 593907001614 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 593907001615 Domain of unknown function DUF20; Region: UPF0118; cl00465 593907001616 threonine dehydratase; Provisional; Region: PRK08198 593907001617 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 593907001618 tetramer interface [polypeptide binding]; other site 593907001619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907001620 catalytic residue [active] 593907001621 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 593907001622 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 593907001623 domain; Region: GreA_GreB_N; pfam03449 593907001624 C-term; Region: GreA_GreB; pfam01272 593907001625 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 593907001626 Predicted amidohydrolase [General function prediction only]; Region: COG0388 593907001627 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 593907001628 active site 593907001629 catalytic triad [active] 593907001630 dimer interface [polypeptide binding]; other site 593907001631 Haemolysin-III related; Region: HlyIII; cl03831 593907001632 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 593907001633 catalytic residue [active] 593907001634 putative FPP diphosphate binding site; other site 593907001635 putative FPP binding hydrophobic cleft; other site 593907001636 dimer interface [polypeptide binding]; other site 593907001637 putative IPP diphosphate binding site; other site 593907001638 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 593907001639 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 593907001640 putative active site [active] 593907001641 PhoH-like protein; Region: PhoH; cl12134 593907001642 TM2 domain; Region: TM2; cl00984 593907001643 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 593907001644 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 593907001645 Walker A/P-loop; other site 593907001646 ATP binding site [chemical binding]; other site 593907001647 Q-loop/lid; other site 593907001648 ABC transporter signature motif; other site 593907001649 Walker B; other site 593907001650 D-loop; other site 593907001651 H-loop/switch region; other site 593907001652 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 593907001653 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 593907001654 Walker A/P-loop; other site 593907001655 ATP binding site [chemical binding]; other site 593907001656 Q-loop/lid; other site 593907001657 ABC transporter signature motif; other site 593907001658 Walker B; other site 593907001659 D-loop; other site 593907001660 H-loop/switch region; other site 593907001661 hypothetical protein; Provisional; Region: PRK08577 593907001662 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907001663 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 593907001664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 593907001665 putative substrate translocation pore; other site 593907001666 fumarate hydratase; Reviewed; Region: fumC; PRK00485 593907001667 Class II fumarases; Region: Fumarase_classII; cd01362 593907001668 active site 593907001669 tetramer interface [polypeptide binding]; other site 593907001670 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 593907001671 active site clefts [active] 593907001672 zinc binding site [ion binding]; other site 593907001673 dimer interface [polypeptide binding]; other site 593907001674 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 593907001675 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907001676 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 593907001677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907001678 dimer interface [polypeptide binding]; other site 593907001679 conserved gate region; other site 593907001680 putative PBP binding loops; other site 593907001681 ABC-ATPase subunit interface; other site 593907001682 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 593907001683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907001684 dimer interface [polypeptide binding]; other site 593907001685 conserved gate region; other site 593907001686 ABC-ATPase subunit interface; other site 593907001687 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 593907001688 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 593907001689 Walker A/P-loop; other site 593907001690 ATP binding site [chemical binding]; other site 593907001691 Q-loop/lid; other site 593907001692 ABC transporter signature motif; other site 593907001693 Walker B; other site 593907001694 D-loop; other site 593907001695 H-loop/switch region; other site 593907001696 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 593907001697 putative substrate binding site [chemical binding]; other site 593907001698 putative ATP binding site [chemical binding]; other site 593907001699 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 593907001700 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 593907001701 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 593907001702 generic binding surface II; other site 593907001703 generic binding surface I; other site 593907001704 LytB protein; Region: LYTB; cl00507 593907001705 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 593907001706 RmuC family; Region: RmuC; pfam02646 593907001707 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 593907001708 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 593907001709 Walker A/P-loop; other site 593907001710 ATP binding site [chemical binding]; other site 593907001711 Q-loop/lid; other site 593907001712 ABC transporter signature motif; other site 593907001713 Walker B; other site 593907001714 D-loop; other site 593907001715 H-loop/switch region; other site 593907001716 GTP-binding protein YchF; Reviewed; Region: PRK09601 593907001717 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 593907001718 G1 box; other site 593907001719 GTP/Mg2+ binding site [chemical binding]; other site 593907001720 Switch I region; other site 593907001721 G2 box; other site 593907001722 Switch II region; other site 593907001723 G3 box; other site 593907001724 G4 box; other site 593907001725 G5 box; other site 593907001726 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 593907001727 Tetratrico peptide repeat; Region: TPR_5; pfam12688 593907001728 Domain of unknown function (DU1801); Region: DUF1801; cl01838 593907001729 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 593907001730 aromatic arch; other site 593907001731 DCoH dimer interaction site [polypeptide binding]; other site 593907001732 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 593907001733 DCoH tetramer interaction site [polypeptide binding]; other site 593907001734 substrate binding site [chemical binding]; other site 593907001735 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 593907001736 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 593907001737 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 593907001738 Domain of unknown function (DUF385); Region: DUF385; cl04387 593907001739 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 593907001740 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 593907001741 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 593907001742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907001743 putative PBP binding loops; other site 593907001744 dimer interface [polypeptide binding]; other site 593907001745 ABC-ATPase subunit interface; other site 593907001746 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 593907001747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907001748 dimer interface [polypeptide binding]; other site 593907001749 conserved gate region; other site 593907001750 putative PBP binding loops; other site 593907001751 ABC-ATPase subunit interface; other site 593907001752 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 593907001753 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 593907001754 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 593907001755 Walker A/P-loop; other site 593907001756 ATP binding site [chemical binding]; other site 593907001757 Q-loop/lid; other site 593907001758 ABC transporter signature motif; other site 593907001759 Walker B; other site 593907001760 D-loop; other site 593907001761 H-loop/switch region; other site 593907001762 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 593907001763 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 593907001764 Walker A/P-loop; other site 593907001765 ATP binding site [chemical binding]; other site 593907001766 Q-loop/lid; other site 593907001767 ABC transporter signature motif; other site 593907001768 Walker B; other site 593907001769 D-loop; other site 593907001770 H-loop/switch region; other site 593907001771 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 593907001772 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 593907001773 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 593907001774 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 593907001775 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 593907001776 G1 box; other site 593907001777 putative GEF interaction site [polypeptide binding]; other site 593907001778 GTP/Mg2+ binding site [chemical binding]; other site 593907001779 Switch I region; other site 593907001780 G2 box; other site 593907001781 G3 box; other site 593907001782 Switch II region; other site 593907001783 G4 box; other site 593907001784 G5 box; other site 593907001785 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 593907001786 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 593907001787 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 593907001788 Flavin Reductases; Region: FlaRed; cl00801 593907001789 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 593907001790 VanW like protein; Region: VanW; pfam04294 593907001791 Ferredoxin [Energy production and conversion]; Region: COG1146 593907001792 4Fe-4S binding domain; Region: Fer4; cl02805 593907001793 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 593907001794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907001795 homodimer interface [polypeptide binding]; other site 593907001796 catalytic residue [active] 593907001797 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 593907001798 dimer interface [polypeptide binding]; other site 593907001799 Citrate synthase; Region: Citrate_synt; pfam00285 593907001800 active site 593907001801 citrylCoA binding site [chemical binding]; other site 593907001802 NADH binding [chemical binding]; other site 593907001803 cationic pore residues; other site 593907001804 oxalacetate/citrate binding site [chemical binding]; other site 593907001805 coenzyme A binding site [chemical binding]; other site 593907001806 catalytic triad [active] 593907001807 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 593907001808 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 593907001809 putative trimer interface [polypeptide binding]; other site 593907001810 putative CoA binding site [chemical binding]; other site 593907001811 UbiA prenyltransferase family; Region: UbiA; cl00337 593907001812 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 593907001813 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 593907001814 naphthoate synthase; Validated; Region: PRK08321 593907001815 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 593907001816 substrate binding site [chemical binding]; other site 593907001817 oxyanion hole (OAH) forming residues; other site 593907001818 trimer interface [polypeptide binding]; other site 593907001819 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway...; Region: OSBS; cd03320 593907001820 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 593907001821 active site 593907001822 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 593907001823 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 593907001824 PYR/PP interface [polypeptide binding]; other site 593907001825 dimer interface [polypeptide binding]; other site 593907001826 TPP binding site [chemical binding]; other site 593907001827 TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key role in the menaquinone biosynthetic pathway, converting...; Region: TPP_SHCHC_synthase; cd02009 593907001828 TPP-binding site; other site 593907001829 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 593907001830 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 593907001831 protein binding site [polypeptide binding]; other site 593907001832 chorismate binding enzyme; Region: Chorismate_bind; cl10555 593907001833 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 593907001834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 593907001835 S-adenosylmethionine binding site [chemical binding]; other site 593907001836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 593907001837 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 593907001838 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 593907001839 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 593907001840 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 593907001841 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 593907001842 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 593907001843 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064 593907001844 putative dimer interface [polypeptide binding]; other site 593907001845 [2Fe-2S] cluster binding site [ion binding]; other site 593907001846 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 593907001847 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 593907001848 SLBB domain; Region: SLBB; pfam10531 593907001849 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 593907001850 NADH dehydrogenase subunit G; Validated; Region: PRK07860 593907001851 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 593907001852 catalytic loop [active] 593907001853 iron binding site [ion binding]; other site 593907001854 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 593907001855 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 593907001856 molybdopterin cofactor binding site; other site 593907001857 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-; Region: MopB_CT; cl09929 593907001858 molybdopterin cofactor binding site; other site 593907001859 NADH dehydrogenase; Region: NADHdh; cl00469 593907001860 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 593907001861 4Fe-4S binding domain; Region: Fer4; cl02805 593907001862 4Fe-4S binding domain; Region: Fer4; cl02805 593907001863 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 593907001864 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 593907001865 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 593907001866 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 593907001867 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 593907001868 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 593907001869 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 593907001870 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 593907001871 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 593907001872 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 593907001873 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 593907001874 substrate binding pocket [chemical binding]; other site 593907001875 chain length determination region; other site 593907001876 substrate-Mg2+ binding site; other site 593907001877 catalytic residues [active] 593907001878 aspartate-rich region 1; other site 593907001879 active site lid residues [active] 593907001880 aspartate-rich region 2; other site 593907001881 RDD family; Region: RDD; cl00746 593907001882 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 593907001883 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907001884 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 593907001885 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907001886 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907001887 Double zinc ribbon; Region: DZR; pfam12773 593907001888 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 593907001889 Proteins of 100 residues with WXG; Region: WXG100; cl02005 593907001890 Proteins of 100 residues with WXG; Region: WXG100; cl02005 593907001891 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 593907001892 active site 593907001893 catalytic residues [active] 593907001894 Proteins of 100 residues with WXG; Region: WXG100; cl02005 593907001895 Proteins of 100 residues with WXG; Region: WXG100; cl02005 593907001896 secretion protein snm4; Region: sec_mycoba_snm4; TIGR02958 593907001897 Protein of unknown function (DUF690); Region: DUF690; cl04939 593907001898 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 593907001899 active site 593907001900 catalytic residues [active] 593907001901 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 593907001902 Active site [active] 593907001903 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 593907001904 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 593907001905 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 593907001906 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to...; Region: CBM20_alpha_amylase; cd05808 593907001907 starch-binding site 2 [chemical binding]; other site 593907001908 starch-binding site 1 [chemical binding]; other site 593907001909 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907001910 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 593907001911 active site 593907001912 Zn-binding site [ion binding]; other site 593907001913 ferredoxin-NADP+ reductase; Region: PLN02852 593907001914 hypothetical protein; Provisional; Region: PRK09897 593907001915 Peptidase family M48; Region: Peptidase_M48; cl12018 593907001916 Protein of unknown function (DUF520); Region: DUF520; cl00723 593907001917 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907001918 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 593907001919 NAD(P) binding site [chemical binding]; other site 593907001920 active site 593907001921 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 593907001922 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 593907001923 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 593907001924 active site 593907001925 catalytic site [active] 593907001926 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 593907001927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 593907001928 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 593907001929 FAD binding domain; Region: FAD_binding_4; pfam01565 593907001930 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 593907001931 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 593907001932 active site 593907001933 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 593907001934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 593907001935 active site 593907001936 phosphorylation site [posttranslational modification] 593907001937 intermolecular recognition site; other site 593907001938 dimerization interface [polypeptide binding]; other site 593907001939 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 593907001940 DNA binding residues [nucleotide binding] 593907001941 dimerization interface [polypeptide binding]; other site 593907001942 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 593907001943 Histidine kinase; Region: HisKA_3; pfam07730 593907001944 ABC-2 type transporter; Region: ABC2_membrane; cl11417 593907001945 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 593907001946 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 593907001947 Walker A/P-loop; other site 593907001948 ATP binding site [chemical binding]; other site 593907001949 Q-loop/lid; other site 593907001950 ABC transporter signature motif; other site 593907001951 Walker B; other site 593907001952 D-loop; other site 593907001953 H-loop/switch region; other site 593907001954 aspartate aminotransferase; Provisional; Region: PRK08361 593907001955 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 593907001956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907001957 homodimer interface [polypeptide binding]; other site 593907001958 catalytic residue [active] 593907001959 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 593907001960 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 593907001961 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 593907001962 putative homodimer interface [polypeptide binding]; other site 593907001963 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 593907001964 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 593907001965 23S rRNA interface [nucleotide binding]; other site 593907001966 L7/L12 interface [polypeptide binding]; other site 593907001967 putative thiostrepton binding site; other site 593907001968 L25 interface [polypeptide binding]; other site 593907001969 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 593907001970 mRNA/rRNA interface [nucleotide binding]; other site 593907001971 Equine arteritis virus serine endopeptidase S32; Region: Peptidase_S32; pfam05579 593907001972 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 593907001973 CHAT domain; Region: CHAT; cl02083 593907001974 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 593907001975 23S rRNA interface [nucleotide binding]; other site 593907001976 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 593907001977 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 593907001978 core dimer interface [polypeptide binding]; other site 593907001979 peripheral dimer interface [polypeptide binding]; other site 593907001980 L10 interface [polypeptide binding]; other site 593907001981 L11 interface [polypeptide binding]; other site 593907001982 putative EF-Tu interaction site [polypeptide binding]; other site 593907001983 putative EF-G interaction site [polypeptide binding]; other site 593907001984 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 593907001985 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 593907001986 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 593907001987 RPB1 interaction site [polypeptide binding]; other site 593907001988 RPB10 interaction site [polypeptide binding]; other site 593907001989 RPB11 interaction site [polypeptide binding]; other site 593907001990 RPB3 interaction site [polypeptide binding]; other site 593907001991 RPB12 interaction site [polypeptide binding]; other site 593907001992 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 593907001993 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 593907001994 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 593907001995 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 593907001996 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 593907001997 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 593907001998 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 593907001999 G-loop; other site 593907002000 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 593907002001 DNA binding site [nucleotide binding] 593907002002 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 593907002003 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 593907002004 S17 interaction site [polypeptide binding]; other site 593907002005 S8 interaction site; other site 593907002006 16S rRNA interaction site [nucleotide binding]; other site 593907002007 streptomycin interaction site [chemical binding]; other site 593907002008 23S rRNA interaction site [nucleotide binding]; other site 593907002009 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 593907002010 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 593907002011 elongation factor G; Reviewed; Region: PRK00007 593907002012 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 593907002013 G1 box; other site 593907002014 putative GEF interaction site [polypeptide binding]; other site 593907002015 GTP/Mg2+ binding site [chemical binding]; other site 593907002016 Switch I region; other site 593907002017 G2 box; other site 593907002018 G3 box; other site 593907002019 Switch II region; other site 593907002020 G4 box; other site 593907002021 G5 box; other site 593907002022 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 593907002023 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 593907002024 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 593907002025 elongation factor Tu; Reviewed; Region: PRK00049 593907002026 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 593907002027 G1 box; other site 593907002028 GEF interaction site [polypeptide binding]; other site 593907002029 GTP/Mg2+ binding site [chemical binding]; other site 593907002030 Switch I region; other site 593907002031 G2 box; other site 593907002032 G3 box; other site 593907002033 Switch II region; other site 593907002034 G4 box; other site 593907002035 G5 box; other site 593907002036 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 593907002037 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 593907002038 Antibiotic Binding Site [chemical binding]; other site 593907002039 IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 593907002040 catalytic site [active] 593907002041 Transcriptional regulators [Transcription]; Region: PurR; COG1609 593907002042 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 593907002043 DNA binding site [nucleotide binding] 593907002044 domain linker motif; other site 593907002045 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 593907002046 ligand binding site [chemical binding]; other site 593907002047 dimerization interface (open form) [polypeptide binding]; other site 593907002048 dimerization interface (closed form) [polypeptide binding]; other site 593907002049 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 593907002050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907002051 dimer interface [polypeptide binding]; other site 593907002052 conserved gate region; other site 593907002053 putative PBP binding loops; other site 593907002054 ABC-ATPase subunit interface; other site 593907002055 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 593907002056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907002057 dimer interface [polypeptide binding]; other site 593907002058 conserved gate region; other site 593907002059 putative PBP binding loops; other site 593907002060 ABC-ATPase subunit interface; other site 593907002061 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 593907002062 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907002063 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 593907002064 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 593907002065 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 593907002066 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 593907002067 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 593907002068 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 593907002069 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 593907002070 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 593907002071 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 593907002072 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 593907002073 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 593907002074 putative translocon binding site; other site 593907002075 protein-rRNA interface [nucleotide binding]; other site 593907002076 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 593907002077 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 593907002078 G-X-X-G motif; other site 593907002079 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 593907002080 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 593907002081 23S rRNA interface [nucleotide binding]; other site 593907002082 5S rRNA interface [nucleotide binding]; other site 593907002083 putative antibiotic binding site [chemical binding]; other site 593907002084 L25 interface [polypeptide binding]; other site 593907002085 L27 interface [polypeptide binding]; other site 593907002086 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 593907002087 L23 interface [polypeptide binding]; other site 593907002088 signal recognition particle (SRP54) interaction site; other site 593907002089 trigger factor interaction site; other site 593907002090 23S rRNA interface [nucleotide binding]; other site 593907002091 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 593907002092 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 593907002093 KOW motif; Region: KOW; cl00354 593907002094 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 593907002095 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 593907002096 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 593907002097 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 593907002098 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 593907002099 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 593907002100 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 593907002101 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 593907002102 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 593907002103 5S rRNA interface [nucleotide binding]; other site 593907002104 L27 interface [polypeptide binding]; other site 593907002105 23S rRNA interface [nucleotide binding]; other site 593907002106 L5 interface [polypeptide binding]; other site 593907002107 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 593907002108 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 593907002109 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 593907002110 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 593907002111 23S rRNA binding site [nucleotide binding]; other site 593907002112 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 593907002113 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 593907002114 SecY translocase; Region: SecY; pfam00344 593907002115 adenylate kinase; Reviewed; Region: adk; PRK00279 593907002116 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 593907002117 AMP-binding site [chemical binding]; other site 593907002118 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 593907002119 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 593907002120 active site 593907002121 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 593907002122 rRNA binding site [nucleotide binding]; other site 593907002123 predicted 30S ribosome binding site; other site 593907002124 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 593907002125 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 593907002126 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 593907002127 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 593907002128 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 593907002129 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 593907002130 alphaNTD - beta interaction site [polypeptide binding]; other site 593907002131 alphaNTD homodimer interface [polypeptide binding]; other site 593907002132 alphaNTD - beta' interaction site [polypeptide binding]; other site 593907002133 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 593907002134 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 593907002135 Putative Ig domain; Region: He_PIG; cl09256 593907002136 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 593907002137 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 593907002138 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 593907002139 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 593907002140 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 593907002141 dimerization interface 3.5A [polypeptide binding]; other site 593907002142 active site 593907002143 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 593907002144 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 593907002145 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 593907002146 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 593907002147 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 593907002148 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907002149 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 593907002150 Walker A/P-loop; other site 593907002151 ATP binding site [chemical binding]; other site 593907002152 Q-loop/lid; other site 593907002153 ABC transporter signature motif; other site 593907002154 Walker B; other site 593907002155 D-loop; other site 593907002156 H-loop/switch region; other site 593907002157 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 593907002158 LysE type translocator; Region: LysE; cl00565 593907002159 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 593907002160 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907002161 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907002162 dimerization interface [polypeptide binding]; other site 593907002163 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 593907002164 23S rRNA interface [nucleotide binding]; other site 593907002165 L3 interface [polypeptide binding]; other site 593907002166 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 593907002167 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 593907002168 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 593907002169 active site 593907002170 substrate binding site [chemical binding]; other site 593907002171 metal binding site [ion binding]; metal-binding site 593907002172 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 593907002173 active site 593907002174 catalytic residues [active] 593907002175 metal binding site [ion binding]; metal-binding site 593907002176 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 593907002177 pantothenate kinase; Provisional; Region: PRK05439 593907002178 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 593907002179 ATP-binding site [chemical binding]; other site 593907002180 CoA-binding site [chemical binding]; other site 593907002181 Mg2+-binding site [ion binding]; other site 593907002182 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 593907002183 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 593907002184 glutaminase active site [active] 593907002185 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 593907002186 dimer interface [polypeptide binding]; other site 593907002187 active site 593907002188 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 593907002189 dimer interface [polypeptide binding]; other site 593907002190 active site 593907002191 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 593907002192 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 593907002193 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 593907002194 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 593907002195 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 593907002196 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 593907002197 alanine racemase; Reviewed; Region: alr; PRK00053 593907002198 active site 593907002199 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 593907002200 dimer interface [polypeptide binding]; other site 593907002201 substrate binding site [chemical binding]; other site 593907002202 catalytic residues [active] 593907002203 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 593907002204 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 593907002205 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 593907002206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907002207 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 593907002208 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 593907002209 active site residue [active] 593907002210 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 593907002211 active site residue [active] 593907002212 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 593907002213 putative FMN binding site [chemical binding]; other site 593907002214 UGMP family protein; Validated; Region: PRK09604 593907002215 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 593907002216 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 593907002217 dimerization interface [polypeptide binding]; other site 593907002218 putative DNA binding site [nucleotide binding]; other site 593907002219 putative Zn2+ binding site [ion binding]; other site 593907002220 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 593907002221 putative hydrophobic ligand binding site [chemical binding]; other site 593907002222 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 593907002223 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 593907002224 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 593907002225 oligomerisation interface [polypeptide binding]; other site 593907002226 mobile loop; other site 593907002227 roof hairpin; other site 593907002228 Transcription factor WhiB; Region: Whib; pfam02467 593907002229 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 593907002230 DNA binding residues [nucleotide binding] 593907002231 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 593907002232 DNA binding residues [nucleotide binding] 593907002233 dimerization interface [polypeptide binding]; other site 593907002234 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 593907002235 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 593907002236 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 593907002237 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 593907002238 active site 593907002239 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 593907002240 active site 593907002241 substrate binding site [chemical binding]; other site 593907002242 catalytic site [active] 593907002243 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 593907002244 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 593907002245 active site 593907002246 Bacterial membrane flanked domain; Region: DUF304; cl01348 593907002247 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 593907002248 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 593907002249 Walker A/P-loop; other site 593907002250 ATP binding site [chemical binding]; other site 593907002251 Q-loop/lid; other site 593907002252 ABC transporter signature motif; other site 593907002253 Walker B; other site 593907002254 D-loop; other site 593907002255 H-loop/switch region; other site 593907002256 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 593907002257 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 593907002258 ABC-ATPase subunit interface; other site 593907002259 dimer interface [polypeptide binding]; other site 593907002260 putative PBP binding regions; other site 593907002261 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 593907002262 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 593907002263 siderophore binding site; other site 593907002264 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 593907002265 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907002266 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 593907002267 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 593907002268 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 593907002269 putative substrate binding site [chemical binding]; other site 593907002270 putative ATP binding site [chemical binding]; other site 593907002271 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 593907002272 active site 593907002273 phosphorylation site [posttranslational modification] 593907002274 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 593907002275 P-loop; other site 593907002276 active site 593907002277 phosphorylation site [posttranslational modification] 593907002278 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 593907002279 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 593907002280 dimerization domain swap beta strand [polypeptide binding]; other site 593907002281 regulatory protein interface [polypeptide binding]; other site 593907002282 active site 593907002283 regulatory phosphorylation site [posttranslational modification]; other site 593907002284 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 593907002285 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 593907002286 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 593907002287 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 593907002288 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 593907002289 NAD(P) binding site [chemical binding]; other site 593907002290 catalytic residues [active] 593907002291 Acetokinase family; Region: Acetate_kinase; cl01029 593907002292 phosphate acetyltransferase; Reviewed; Region: PRK05632 593907002293 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 593907002294 DRTGG domain; Region: DRTGG; cl12147 593907002295 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 593907002296 putative phosphoketolase; Provisional; Region: PRK05261 593907002297 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 593907002298 TPP-binding site; other site 593907002299 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 593907002300 XFP C-terminal domain; Region: XFP_C; pfam09363 593907002301 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 593907002302 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 593907002303 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 593907002304 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907002305 Walker A/P-loop; other site 593907002306 ATP binding site [chemical binding]; other site 593907002307 Q-loop/lid; other site 593907002308 ABC transporter signature motif; other site 593907002309 Walker B; other site 593907002310 D-loop; other site 593907002311 H-loop/switch region; other site 593907002312 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 593907002313 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 593907002314 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907002315 Walker A/P-loop; other site 593907002316 ATP binding site [chemical binding]; other site 593907002317 Q-loop/lid; other site 593907002318 ABC transporter signature motif; other site 593907002319 Walker B; other site 593907002320 D-loop; other site 593907002321 H-loop/switch region; other site 593907002322 GMP synthase; Reviewed; Region: guaA; PRK00074 593907002323 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 593907002324 AMP/PPi binding site [chemical binding]; other site 593907002325 candidate oxyanion hole; other site 593907002326 catalytic triad [active] 593907002327 potential glutamine specificity residues [chemical binding]; other site 593907002328 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 593907002329 ATP Binding subdomain [chemical binding]; other site 593907002330 Ligand Binding sites [chemical binding]; other site 593907002331 Dimerization subdomain; other site 593907002332 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 593907002333 PspC domain; Region: PspC; cl00864 593907002334 PspC domain; Region: PspC; cl00864 593907002335 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 593907002336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 593907002337 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 593907002338 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 593907002339 DNA binding residues [nucleotide binding] 593907002340 dimerization interface [polypeptide binding]; other site 593907002341 Cache domain; Region: Cache_2; pfam08269 593907002342 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 593907002343 Protein of unknown function (DUF456); Region: DUF456; cl01069 593907002344 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 593907002345 UvrD/REP helicase; Region: UvrD-helicase; cl14126 593907002346 UvrD/REP helicase; Region: UvrD-helicase; cl14126 593907002347 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 593907002348 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 593907002349 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 593907002350 active site 593907002351 catalytic triad [active] 593907002352 oxyanion hole [active] 593907002353 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 593907002354 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 593907002355 CoA-ligase; Region: Ligase_CoA; pfam00549 593907002356 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 593907002357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907002358 CoA-ligase; Region: Ligase_CoA; pfam00549 593907002359 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 593907002360 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 593907002361 active site 593907002362 substrate binding site [chemical binding]; other site 593907002363 cosubstrate binding site; other site 593907002364 catalytic site [active] 593907002365 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 593907002366 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 593907002367 purine monophosphate binding site [chemical binding]; other site 593907002368 dimer interface [polypeptide binding]; other site 593907002369 putative catalytic residues [active] 593907002370 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 593907002371 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 593907002372 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 593907002373 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cl00200 593907002374 amphipathic channel; other site 593907002375 Asn-Pro-Ala signature motifs; other site 593907002376 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 593907002377 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 593907002378 Coenzyme A binding pocket [chemical binding]; other site 593907002379 malate dehydrogenase; Provisional; Region: PRK05442 593907002380 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 593907002381 NAD(P) binding site [chemical binding]; other site 593907002382 dimer interface [polypeptide binding]; other site 593907002383 malate binding site [chemical binding]; other site 593907002384 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 593907002385 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 593907002386 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 593907002387 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 593907002388 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 593907002389 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 593907002390 anti sigma factor interaction site; other site 593907002391 regulatory phosphorylation site [posttranslational modification]; other site 593907002392 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 593907002393 active site 593907002394 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 593907002395 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 593907002396 PAS fold; Region: PAS_4; pfam08448 593907002397 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 593907002398 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 593907002399 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 593907002400 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 593907002401 active site 593907002402 substrate binding site [chemical binding]; other site 593907002403 cosubstrate binding site; other site 593907002404 catalytic site [active] 593907002405 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907002406 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907002407 Phosphotransferase enzyme family; Region: APH; pfam01636 593907002408 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (...; Region: APH; cd05150 593907002409 active site 593907002410 ATP binding site [chemical binding]; other site 593907002411 antibiotic binding site [chemical binding]; other site 593907002412 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 593907002413 dimer interface [polypeptide binding]; other site 593907002414 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 593907002415 putative hydrophobic ligand binding site [chemical binding]; other site 593907002416 EamA-like transporter family; Region: EamA; cl01037 593907002417 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907002418 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 593907002419 dimer interface [polypeptide binding]; other site 593907002420 glycine-pyridoxal phosphate binding site [chemical binding]; other site 593907002421 active site 593907002422 folate binding site [chemical binding]; other site 593907002423 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 593907002424 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 593907002425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907002426 NAD(P) binding pocket [chemical binding]; other site 593907002427 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 593907002428 putative catalytic site [active] 593907002429 putative metal binding site [ion binding]; other site 593907002430 putative phosphate binding site [ion binding]; other site 593907002431 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 593907002432 DNA-binding site [nucleotide binding]; DNA binding site 593907002433 H+ Antiporter protein; Region: 2A0121; TIGR00900 593907002434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 593907002435 putative substrate translocation pore; other site 593907002436 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 593907002437 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 593907002438 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 593907002439 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 593907002440 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 593907002441 nucleotide binding site/active site [active] 593907002442 HIT family signature motif; other site 593907002443 catalytic residue [active] 593907002444 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 593907002445 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907002446 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 593907002447 Domain of unknown function DUF59; Region: DUF59; cl00941 593907002448 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 593907002449 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 593907002450 Walker A motif; other site 593907002451 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 593907002452 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 593907002453 MgtE intracellular N domain; Region: MgtE_N; cl15244 593907002454 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 593907002455 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 593907002456 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087 593907002457 active site 593907002458 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 593907002459 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 593907002460 MarC family integral membrane protein; Region: MarC; cl00919 593907002461 helicase 45; Provisional; Region: PTZ00424 593907002462 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 593907002463 ATP binding site [chemical binding]; other site 593907002464 Mg++ binding site [ion binding]; other site 593907002465 motif III; other site 593907002466 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 593907002467 nucleotide binding region [chemical binding]; other site 593907002468 ATP-binding site [chemical binding]; other site 593907002469 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 593907002470 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 593907002471 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 593907002472 UvrD/REP helicase; Region: UvrD-helicase; cl14126 593907002473 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 593907002474 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 593907002475 UvrD/REP helicase; Region: UvrD-helicase; cl14126 593907002476 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 593907002477 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 593907002478 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 593907002479 active site 593907002480 ATP binding site [chemical binding]; other site 593907002481 substrate binding site [chemical binding]; other site 593907002482 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 593907002483 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 593907002484 putative NADH binding site [chemical binding]; other site 593907002485 putative active site [active] 593907002486 nudix motif; other site 593907002487 putative metal binding site [ion binding]; other site 593907002488 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 593907002489 catalytic residues [active] 593907002490 UvrD/REP helicase; Region: UvrD-helicase; cl14126 593907002491 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 593907002492 HRDC domain; Region: HRDC; cl02578 593907002493 Transcription factor WhiB; Region: Whib; pfam02467 593907002494 Protein of unknown function DUF45; Region: DUF45; cl00636 593907002495 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 593907002496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907002497 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 593907002498 Uncharacterised protein family (UPF0182); Region: UPF0182; pfam03699 593907002499 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 593907002500 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 593907002501 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 593907002502 intersubunit interface [polypeptide binding]; other site 593907002503 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 593907002504 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907002505 Walker A/P-loop; other site 593907002506 ATP binding site [chemical binding]; other site 593907002507 Q-loop/lid; other site 593907002508 ABC transporter signature motif; other site 593907002509 Walker B; other site 593907002510 D-loop; other site 593907002511 H-loop/switch region; other site 593907002512 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 593907002513 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 593907002514 metal binding site 2 [ion binding]; metal-binding site 593907002515 putative DNA binding helix; other site 593907002516 metal binding site 1 [ion binding]; metal-binding site 593907002517 dimer interface [polypeptide binding]; other site 593907002518 structural Zn2+ binding site [ion binding]; other site 593907002519 CsbD-like; Region: CsbD; cl01272 593907002520 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907002521 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cd00016 593907002522 dimer interface [polypeptide binding]; other site 593907002523 Alkaline phosphatase homologues; Region: alkPPc; smart00098 593907002524 active site 593907002525 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 593907002526 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 593907002527 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 593907002528 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 593907002529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566 593907002530 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 593907002531 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 593907002532 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 593907002533 OsmC-like protein; Region: OsmC; cl00767 593907002534 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 593907002535 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 593907002536 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 593907002537 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 593907002538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907002539 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 593907002540 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 593907002541 Predicted membrane protein (DUF2079); Region: DUF2079; cl01374 593907002542 AlkA N-terminal domain; Region: AlkA_N; pfam06029 593907002543 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 593907002544 minor groove reading motif; other site 593907002545 helix-hairpin-helix signature motif; other site 593907002546 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 593907002547 Mechanosensitive ion channel; Region: MS_channel; pfam00924 593907002548 classical (c) SDRs; Region: SDR_c; cd05233 593907002549 NAD(P) binding site [chemical binding]; other site 593907002550 active site 593907002551 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 593907002552 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 593907002553 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 593907002554 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754 593907002555 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 593907002556 [4Fe-4S] binding site [ion binding]; other site 593907002557 molybdopterin cofactor binding site; other site 593907002558 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 593907002559 molybdopterin cofactor binding site; other site 593907002560 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 593907002561 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 593907002562 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 593907002563 FAD binding pocket [chemical binding]; other site 593907002564 conserved FAD binding motif [chemical binding]; other site 593907002565 phosphate binding motif [ion binding]; other site 593907002566 beta-alpha-beta structure motif; other site 593907002567 NAD binding pocket [chemical binding]; other site 593907002568 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 593907002569 Moco binding site; other site 593907002570 metal coordination site [ion binding]; other site 593907002571 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 593907002572 nucleotide binding site/active site [active] 593907002573 HIT family signature motif; other site 593907002574 catalytic residue [active] 593907002575 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 593907002576 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 593907002577 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907002578 Walker A/P-loop; other site 593907002579 ATP binding site [chemical binding]; other site 593907002580 Q-loop/lid; other site 593907002581 ABC transporter signature motif; other site 593907002582 Walker B; other site 593907002583 D-loop; other site 593907002584 H-loop/switch region; other site 593907002585 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 593907002586 nitrite reductase subunit NirD; Provisional; Region: PRK14989 593907002587 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 593907002588 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 593907002589 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 593907002590 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain...; Region: Rieske_NirD; cd03529 593907002591 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 593907002592 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 593907002593 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 593907002594 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 593907002595 active site 593907002596 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 593907002597 DNA binding site [nucleotide binding] 593907002598 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416 593907002599 putative active site [active] 593907002600 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and...; Region: Chelatase_Class_II; cl02784 593907002601 active site 593907002602 Predicted membrane protein [Function unknown]; Region: COG1511 593907002603 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 593907002604 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 593907002605 putative metal binding site [ion binding]; other site 593907002606 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 593907002607 Cellulose binding domain; Region: CBM_2; cl02709 593907002608 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907002609 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 593907002610 Transcriptional regulators [Transcription]; Region: PurR; COG1609 593907002611 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 593907002612 DNA binding site [nucleotide binding] 593907002613 domain linker motif; other site 593907002614 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 593907002615 putative dimerization interface [polypeptide binding]; other site 593907002616 putative ligand binding site [chemical binding]; other site 593907002617 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 593907002618 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 593907002619 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907002620 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 593907002621 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907002622 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907002623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907002624 dimer interface [polypeptide binding]; other site 593907002625 conserved gate region; other site 593907002626 putative PBP binding loops; other site 593907002627 ABC-ATPase subunit interface; other site 593907002628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907002629 dimer interface [polypeptide binding]; other site 593907002630 conserved gate region; other site 593907002631 putative PBP binding loops; other site 593907002632 ABC-ATPase subunit interface; other site 593907002633 ferrochelatase; Reviewed; Region: hemH; PRK00035 593907002634 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 593907002635 C-terminal domain interface [polypeptide binding]; other site 593907002636 active site 593907002637 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 593907002638 active site 593907002639 N-terminal domain interface [polypeptide binding]; other site 593907002640 Chlorite dismutase; Region: Chlor_dismutase; cl01280 593907002641 META domain; Region: META; cl01245 593907002642 glutamate dehydrogenase; Region: PLN02477 593907002643 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 593907002644 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 593907002645 NAD(P) binding site [chemical binding]; other site 593907002646 Transcriptional regulators [Transcription]; Region: PurR; COG1609 593907002647 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 593907002648 DNA binding site [nucleotide binding] 593907002649 domain linker motif; other site 593907002650 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 593907002651 putative dimerization interface [polypeptide binding]; other site 593907002652 putative ligand binding site [chemical binding]; other site 593907002653 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 593907002654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907002655 dimer interface [polypeptide binding]; other site 593907002656 conserved gate region; other site 593907002657 putative PBP binding loops; other site 593907002658 ABC-ATPase subunit interface; other site 593907002659 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 593907002660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907002661 putative PBP binding loops; other site 593907002662 ABC-ATPase subunit interface; other site 593907002663 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 593907002664 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907002665 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 593907002666 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 593907002667 PAS fold; Region: PAS_4; pfam08448 593907002668 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 593907002669 Histidine kinase; Region: HisKA_2; cl06527 593907002670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 593907002671 ATP binding site [chemical binding]; other site 593907002672 G-X-G motif; other site 593907002673 Transcription factor WhiB; Region: Whib; pfam02467 593907002674 FtsX-like permease family; Region: FtsX; pfam02687 593907002675 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 593907002676 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 593907002677 Walker A/P-loop; other site 593907002678 ATP binding site [chemical binding]; other site 593907002679 Q-loop/lid; other site 593907002680 ABC transporter signature motif; other site 593907002681 Walker B; other site 593907002682 D-loop; other site 593907002683 H-loop/switch region; other site 593907002684 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 593907002685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 593907002686 active site 593907002687 phosphorylation site [posttranslational modification] 593907002688 intermolecular recognition site; other site 593907002689 dimerization interface [polypeptide binding]; other site 593907002690 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 593907002691 DNA binding residues [nucleotide binding] 593907002692 dimerization interface [polypeptide binding]; other site 593907002693 Histidine kinase; Region: HisKA_3; pfam07730 593907002694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 593907002695 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 593907002696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 593907002697 active site 593907002698 phosphorylation site [posttranslational modification] 593907002699 intermolecular recognition site; other site 593907002700 dimerization interface [polypeptide binding]; other site 593907002701 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 593907002702 DNA binding site [nucleotide binding] 593907002703 sensor protein BasS/PmrB; Provisional; Region: PRK10755 593907002704 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 593907002705 dimer interface [polypeptide binding]; other site 593907002706 phosphorylation site [posttranslational modification] 593907002707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 593907002708 ATP binding site [chemical binding]; other site 593907002709 Mg2+ binding site [ion binding]; other site 593907002710 G-X-G motif; other site 593907002711 mannose-6-phosphate isomerase; Provisional; Region: PRK15131; cl14659 593907002712 Phosphomannose isomerase type I; Region: PMI_typeI; pfam01238 593907002713 GtrA-like protein; Region: GtrA; cl00971 593907002714 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 593907002715 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 593907002716 AIR carboxylase; Region: AIRC; cl00310 593907002717 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 593907002718 active site 593907002719 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 593907002720 active site 593907002721 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 593907002722 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 593907002723 NeuB family; Region: NeuB; cl00496 593907002724 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 593907002725 ligand binding site [chemical binding]; other site 593907002726 tetramer interface [polypeptide binding]; other site 593907002727 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 593907002728 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 593907002729 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 593907002730 active site 593907002731 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 593907002732 active site 593907002733 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 593907002734 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 593907002735 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 593907002736 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 593907002737 ligand-binding site [chemical binding]; other site 593907002738 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 593907002739 active site 593907002740 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 593907002741 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 593907002742 Active Sites [active] 593907002743 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 593907002744 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 593907002745 CysD dimerization site [polypeptide binding]; other site 593907002746 G1 box; other site 593907002747 putative GEF interaction site [polypeptide binding]; other site 593907002748 GTP/Mg2+ binding site [chemical binding]; other site 593907002749 Switch I region; other site 593907002750 G2 box; other site 593907002751 G3 box; other site 593907002752 Switch II region; other site 593907002753 G4 box; other site 593907002754 G5 box; other site 593907002755 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695 593907002756 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095 593907002757 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 593907002758 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 593907002759 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 593907002760 active site 593907002761 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 593907002762 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 593907002763 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 593907002764 Ligand binding site [chemical binding]; other site 593907002765 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 593907002766 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 593907002767 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 593907002768 Walker A/P-loop; other site 593907002769 ATP binding site [chemical binding]; other site 593907002770 Q-loop/lid; other site 593907002771 ABC transporter signature motif; other site 593907002772 Walker B; other site 593907002773 D-loop; other site 593907002774 H-loop/switch region; other site 593907002775 ABC-2 type transporter; Region: ABC2_membrane; cl11417 593907002776 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 593907002777 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907002778 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 593907002779 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 593907002780 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 593907002781 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 593907002782 active site 593907002783 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 593907002784 homodimer interface [polypeptide binding]; other site 593907002785 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 593907002786 active site 593907002787 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 593907002788 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 593907002789 active site 593907002790 PEP-CTERM/exosortase 1-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 593907002791 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 593907002792 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 593907002793 active site 593907002794 Stage II sporulation protein; Region: SpoIID; cl07201 593907002795 Stage II sporulation protein; Region: SpoIID; cl07201 593907002796 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 593907002797 amidase catalytic site [active] 593907002798 Zn binding residues [ion binding]; other site 593907002799 substrate binding site [chemical binding]; other site 593907002800 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 593907002801 Transcription factor WhiB; Region: Whib; pfam02467 593907002802 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 593907002803 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 593907002804 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 593907002805 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 593907002806 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 593907002807 active site 593907002808 substrate binding site [chemical binding]; other site 593907002809 metal binding site [ion binding]; metal-binding site 593907002810 Cation efflux family; Region: Cation_efflux; cl00316 593907002811 RDD family; Region: RDD; cl00746 593907002812 Integral membrane protein DUF95; Region: DUF95; cl00572 593907002813 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 593907002814 Protein of unknown function DUF58; Region: DUF58; pfam01882 593907002815 MoxR-like ATPases [General function prediction only]; Region: COG0714 593907002816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 593907002817 Walker A motif; other site 593907002818 ATP binding site [chemical binding]; other site 593907002819 Walker B motif; other site 593907002820 arginine finger; other site 593907002821 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 593907002822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 593907002823 active site 593907002824 phosphorylation site [posttranslational modification] 593907002825 intermolecular recognition site; other site 593907002826 dimerization interface [polypeptide binding]; other site 593907002827 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 593907002828 DNA binding site [nucleotide binding] 593907002829 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 593907002830 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 593907002831 dimerization interface [polypeptide binding]; other site 593907002832 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 593907002833 dimer interface [polypeptide binding]; other site 593907002834 phosphorylation site [posttranslational modification] 593907002835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 593907002836 ATP binding site [chemical binding]; other site 593907002837 G-X-G motif; other site 593907002838 lipoprotein LpqB; Provisional; Region: PRK13614 593907002839 Sporulation and spore germination; Region: Germane; pfam10646 593907002840 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 593907002841 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 593907002842 30S subunit binding site; other site 593907002843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 593907002844 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 593907002845 EamA-like transporter family; Region: EamA; cl01037 593907002846 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 593907002847 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 593907002848 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 593907002849 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 593907002850 nucleotide binding region [chemical binding]; other site 593907002851 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 593907002852 putative peptidoglycan binding site; other site 593907002853 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 593907002854 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 593907002855 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907002856 Transcriptional regulator [Transcription]; Region: IclR; COG1414 593907002857 Bacterial transcriptional regulator; Region: IclR; pfam01614 593907002858 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 593907002859 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 593907002860 substrate binding site [chemical binding]; other site 593907002861 ligand binding site [chemical binding]; other site 593907002862 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 593907002863 substrate binding site [chemical binding]; other site 593907002864 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 593907002865 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 593907002866 hinge; other site 593907002867 active site 593907002868 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 593907002869 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 593907002870 putative acyl-acceptor binding pocket; other site 593907002871 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 593907002872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907002873 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 593907002874 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 593907002875 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 593907002876 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 593907002877 catalytic residue [active] 593907002878 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 593907002879 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 593907002880 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 593907002881 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 593907002882 thiamine monophosphate kinase; Provisional; Region: PRK05731 593907002883 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 593907002884 ATP binding site [chemical binding]; other site 593907002885 dimerization interface [polypeptide binding]; other site 593907002886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907002887 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 593907002888 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 593907002889 DAK2 domain; Region: Dak2; cl03685 593907002890 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 593907002891 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 593907002892 generic binding surface II; other site 593907002893 ssDNA binding site; other site 593907002894 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 593907002895 ATP binding site [chemical binding]; other site 593907002896 putative Mg++ binding site [ion binding]; other site 593907002897 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 593907002898 nucleotide binding region [chemical binding]; other site 593907002899 ATP-binding site [chemical binding]; other site 593907002900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 593907002901 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907002902 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 593907002903 active site 593907002904 (T/H)XGH motif; other site 593907002905 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 593907002906 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 593907002907 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 593907002908 dimerization interface [polypeptide binding]; other site 593907002909 active site 593907002910 metal binding site [ion binding]; metal-binding site 593907002911 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 593907002912 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 593907002913 DNA binding site [nucleotide binding] 593907002914 catalytic residue [active] 593907002915 H2TH interface [polypeptide binding]; other site 593907002916 putative catalytic residues [active] 593907002917 turnover-facilitating residue; other site 593907002918 intercalation triad [nucleotide binding]; other site 593907002919 8OG recognition residue [nucleotide binding]; other site 593907002920 putative reading head residues; other site 593907002921 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 593907002922 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 593907002923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907002924 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 593907002925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 593907002926 active site 593907002927 phosphorylation site [posttranslational modification] 593907002928 intermolecular recognition site; other site 593907002929 dimerization interface [polypeptide binding]; other site 593907002930 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 593907002931 DNA binding residues [nucleotide binding] 593907002932 dimerization interface [polypeptide binding]; other site 593907002933 GAF domain; Region: GAF; cl00853 593907002934 Histidine kinase; Region: HisKA_3; pfam07730 593907002935 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 593907002936 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 593907002937 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 593907002938 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907002939 Walker A/P-loop; other site 593907002940 ATP binding site [chemical binding]; other site 593907002941 Q-loop/lid; other site 593907002942 ABC transporter signature motif; other site 593907002943 Walker B; other site 593907002944 D-loop; other site 593907002945 H-loop/switch region; other site 593907002946 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 593907002947 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 593907002948 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907002949 Walker A/P-loop; other site 593907002950 ATP binding site [chemical binding]; other site 593907002951 Q-loop/lid; other site 593907002952 ABC transporter signature motif; other site 593907002953 Walker B; other site 593907002954 D-loop; other site 593907002955 H-loop/switch region; other site 593907002956 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 593907002957 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 593907002958 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 593907002959 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 593907002960 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 593907002961 homodimer interface [polypeptide binding]; other site 593907002962 oligonucleotide binding site [chemical binding]; other site 593907002963 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 593907002964 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 593907002965 GTPase CgtA; Reviewed; Region: obgE; PRK12296 593907002966 GTP1/OBG; Region: GTP1_OBG; pfam01018 593907002967 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 593907002968 G1 box; other site 593907002969 GTP/Mg2+ binding site [chemical binding]; other site 593907002970 Switch I region; other site 593907002971 G2 box; other site 593907002972 G3 box; other site 593907002973 Switch II region; other site 593907002974 G4 box; other site 593907002975 G5 box; other site 593907002976 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 593907002977 gamma-glutamyl kinase; Provisional; Region: PRK05429 593907002978 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 593907002979 nucleotide binding site [chemical binding]; other site 593907002980 homotetrameric interface [polypeptide binding]; other site 593907002981 putative phosphate binding site [ion binding]; other site 593907002982 putative allosteric binding site; other site 593907002983 PUA domain; Region: PUA; cl00607 593907002984 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 593907002985 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 593907002986 putative catalytic cysteine [active] 593907002987 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 593907002988 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 593907002989 active site 593907002990 (T/H)XGH motif; other site 593907002991 Domain of unknown function DUF143; Region: DUF143; cl00519 593907002992 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 593907002993 catalytic core [active] 593907002994 Protein of unknown function, DUF488; Region: DUF488; cl01246 593907002995 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 593907002996 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 593907002997 DNA binding residues [nucleotide binding] 593907002998 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 593907002999 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 593907003000 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 593907003001 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 593907003002 nudix motif; other site 593907003003 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 593907003004 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 593907003005 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 593907003006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907003007 dimer interface [polypeptide binding]; other site 593907003008 ABC-ATPase subunit interface; other site 593907003009 putative PBP binding loops; other site 593907003010 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 593907003011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 593907003012 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 593907003013 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 593907003014 Walker A/P-loop; other site 593907003015 ATP binding site [chemical binding]; other site 593907003016 Q-loop/lid; other site 593907003017 ABC transporter signature motif; other site 593907003018 Walker B; other site 593907003019 D-loop; other site 593907003020 H-loop/switch region; other site 593907003021 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 593907003022 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 593907003023 Walker A/P-loop; other site 593907003024 ATP binding site [chemical binding]; other site 593907003025 Q-loop/lid; other site 593907003026 ABC transporter signature motif; other site 593907003027 Walker B; other site 593907003028 D-loop; other site 593907003029 H-loop/switch region; other site 593907003030 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 593907003031 Predicted membrane protein [Function unknown]; Region: COG4425 593907003032 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 593907003033 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 593907003034 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 593907003035 putative active site [active] 593907003036 putative metal binding residues [ion binding]; other site 593907003037 signature motif; other site 593907003038 putative dimer interface [polypeptide binding]; other site 593907003039 putative phosphate binding site [ion binding]; other site 593907003040 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 593907003041 GST_C family, ECM4-like subfamily; composed of predominantly uncharacterized and taxonomically diverse proteins with similarity to the translation product of the Saccharomyces cerevisiae gene ECM4. ECM4, a gene of unknown function, is involved in cell...; Region: GST_C_ECM4_like; cd03190 593907003042 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 593907003043 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 593907003044 active site 593907003045 metal binding site [ion binding]; metal-binding site 593907003046 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which...; Region: B_lectin; cl00039 593907003047 dimerization interface [polypeptide binding]; other site 593907003048 mannose binding site [chemical binding]; other site 593907003049 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 593907003050 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907003051 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 593907003052 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 593907003053 MFS transport protein AraJ; Provisional; Region: PRK10091 593907003054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 593907003055 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 593907003056 aminoacyl-tRNA ligase; Region: PLN02563 593907003057 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 593907003058 active site 593907003059 HIGH motif; other site 593907003060 nucleotide binding site [chemical binding]; other site 593907003061 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 593907003062 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 593907003063 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 593907003064 active site 593907003065 KMSKS motif; other site 593907003066 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 593907003067 tRNA binding surface [nucleotide binding]; other site 593907003068 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 593907003069 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 593907003070 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 593907003071 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 593907003072 Competence protein; Region: Competence; cl00471 593907003073 hypothetical protein; Reviewed; Region: PRK07914 593907003074 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 593907003075 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 593907003076 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 593907003077 PemK-like protein; Region: PemK; cl00995 593907003078 Uncharacterized conserved protein [Function unknown]; Region: COG2308 593907003079 Domain of unknown function (DUF404); Region: DUF404; pfam04169 593907003080 Domain of unknown function (DUF407); Region: DUF407; pfam04174 593907003081 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 593907003082 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 593907003083 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 593907003084 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 593907003085 DinB superfamily; Region: DinB_2; cl00986 593907003086 GTP-binding protein LepA; Provisional; Region: PRK05433 593907003087 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 593907003088 G1 box; other site 593907003089 putative GEF interaction site [polypeptide binding]; other site 593907003090 GTP/Mg2+ binding site [chemical binding]; other site 593907003091 Switch I region; other site 593907003092 G2 box; other site 593907003093 G3 box; other site 593907003094 Switch II region; other site 593907003095 G4 box; other site 593907003096 G5 box; other site 593907003097 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding...; Region: Translation_Factor_II_like; cl02787 593907003098 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 593907003099 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 593907003100 coproporphyrinogen III oxidase; Validated; Region: PRK05628 593907003101 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 593907003102 FeS/SAM binding site; other site 593907003103 HemN C-terminal region; Region: HemN_C; pfam06969 593907003104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 593907003105 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 593907003106 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 593907003107 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 593907003108 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907003109 HrcA protein C terminal domain; Region: HrcA; pfam01628 593907003110 chaperone protein DnaJ; Provisional; Region: PRK14278 593907003111 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 593907003112 HSP70 interaction site [polypeptide binding]; other site 593907003113 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 593907003114 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 593907003115 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 593907003116 pyruvate phosphate dikinase; Provisional; Region: PRK09279 593907003117 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 593907003118 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 593907003119 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 593907003120 PhoH-like protein; Region: PhoH; cl12134 593907003121 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 593907003122 FOG: CBS domain [General function prediction only]; Region: COG0517 593907003123 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 593907003124 Transporter associated domain; Region: CorC_HlyC; pfam03471 593907003125 GTPase Era; Reviewed; Region: era; PRK00089 593907003126 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 593907003127 G1 box; other site 593907003128 GTP/Mg2+ binding site [chemical binding]; other site 593907003129 Switch I region; other site 593907003130 G2 box; other site 593907003131 Switch II region; other site 593907003132 G3 box; other site 593907003133 G4 box; other site 593907003134 G5 box; other site 593907003135 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 593907003136 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 593907003137 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 593907003138 Protein phosphatase 2C; Region: PP2C; pfam00481 593907003139 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 593907003140 Active site [active] 593907003141 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 593907003142 phosphopeptide binding site; other site 593907003143 Protein kinase domain; Region: Pkinase; pfam00069 593907003144 Catalytic domain of Protein Kinases; Region: PKc; cd00180 593907003145 active site 593907003146 ATP binding site [chemical binding]; other site 593907003147 substrate binding site [chemical binding]; other site 593907003148 activation loop (A-loop); other site 593907003149 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 593907003150 Interdomain contacts; other site 593907003151 Cytokine receptor motif; other site 593907003152 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 593907003153 Interdomain contacts; other site 593907003154 Cytokine receptor motif; other site 593907003155 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 593907003156 MoxR-like ATPases [General function prediction only]; Region: COG0714 593907003157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 593907003158 Walker A motif; other site 593907003159 ATP binding site [chemical binding]; other site 593907003160 Walker B motif; other site 593907003161 arginine finger; other site 593907003162 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 593907003163 Protein of unknown function DUF58; Region: DUF58; pfam01882 593907003164 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 593907003165 RDD family; Region: RDD; cl00746 593907003166 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 593907003167 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 593907003168 2-isopropylmalate synthase; Validated; Region: PRK03739 593907003169 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 593907003170 active site 593907003171 catalytic residues [active] 593907003172 metal binding site [ion binding]; metal-binding site 593907003173 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 593907003174 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 593907003175 Recombination protein O N terminal; Region: RecO_N; pfam11967 593907003176 Recombination protein O C terminal; Region: RecO_C; pfam02565 593907003177 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 593907003178 catalytic residue [active] 593907003179 putative FPP diphosphate binding site; other site 593907003180 putative FPP binding hydrophobic cleft; other site 593907003181 dimer interface [polypeptide binding]; other site 593907003182 putative IPP diphosphate binding site; other site 593907003183 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 593907003184 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 593907003185 Walker A/P-loop; other site 593907003186 ATP binding site [chemical binding]; other site 593907003187 Q-loop/lid; other site 593907003188 ABC transporter signature motif; other site 593907003189 Walker B; other site 593907003190 D-loop; other site 593907003191 H-loop/switch region; other site 593907003192 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 593907003193 active site 593907003194 metal binding site [ion binding]; metal-binding site 593907003195 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 593907003196 glycyl-tRNA synthetase; Provisional; Region: PRK04173 593907003197 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 593907003198 motif 1; other site 593907003199 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the...; Region: GlyRS-like_core; cd00774 593907003200 active site 593907003201 motif 2; other site 593907003202 motif 3; other site 593907003203 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 593907003204 anticodon binding site; other site 593907003205 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 593907003206 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 593907003207 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 593907003208 DNA binding residues [nucleotide binding] 593907003209 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 593907003210 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 593907003211 FMN binding site [chemical binding]; other site 593907003212 active site 593907003213 catalytic residues [active] 593907003214 substrate binding site [chemical binding]; other site 593907003215 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 593907003216 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 593907003217 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 593907003218 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 593907003219 trehalose synthase; Region: treS_nterm; TIGR02456 593907003220 Transcriptional regulators [Transcription]; Region: PurR; COG1609 593907003221 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 593907003222 DNA binding site [nucleotide binding] 593907003223 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 593907003224 putative dimerization interface [polypeptide binding]; other site 593907003225 putative ligand binding site [chemical binding]; other site 593907003226 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907003227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907003228 dimer interface [polypeptide binding]; other site 593907003229 conserved gate region; other site 593907003230 putative PBP binding loops; other site 593907003231 ABC-ATPase subunit interface; other site 593907003232 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 593907003233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907003234 dimer interface [polypeptide binding]; other site 593907003235 conserved gate region; other site 593907003236 putative PBP binding loops; other site 593907003237 ABC-ATPase subunit interface; other site 593907003238 CD and pullulan-degrading enzymes N-terminus domain. Members of this subgroup include: Cyclomaltodextrinase (CDase), maltogenic amylase, and neopullulanase all of which are capable of hydrolyzing all or two of the following three types of substrates:...; Region: CD_pullulan_degrading_enzymes_N_term; cd02857 593907003239 homodimer; other site 593907003240 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 593907003241 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 593907003242 Cellulose binding domain; Region: CBM_2; cl02709 593907003243 Glycosyl hydrolase family 18; Region: Glyco_18; smart00636 593907003244 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is...; Region: GH18_chitinase; cd06548 593907003245 active site 593907003246 DNA primase; Validated; Region: dnaG; PRK05667 593907003247 CHC2 zinc finger; Region: zf-CHC2; cl02597 593907003248 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 593907003249 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 593907003250 active site 593907003251 metal binding site [ion binding]; metal-binding site 593907003252 interdomain interaction site; other site 593907003253 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 593907003254 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 593907003255 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 593907003256 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 593907003257 intersubunit interface [polypeptide binding]; other site 593907003258 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 593907003259 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 593907003260 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 593907003261 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 593907003262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 593907003263 putative substrate translocation pore; other site 593907003264 Major Facilitator Superfamily; Region: MFS_1; pfam07690 593907003265 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 593907003266 Peptidase M15; Region: Peptidase_M15_3; cl01194 593907003267 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 593907003268 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 593907003269 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 593907003270 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 593907003271 Phage Terminase; Region: Terminase_1; pfam03354 593907003272 Phage terminase, small subunit; Region: Terminase_4; cl01525 593907003273 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 593907003274 hypothetical protein; Reviewed; Region: PRK09588 593907003275 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 593907003276 VRR-NUC domain; Region: VRR_NUC; pfam08774 593907003277 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 593907003278 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 593907003279 DNA binding residues [nucleotide binding] 593907003280 ParB-like nuclease domain; Region: ParBc; cl02129 593907003281 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 593907003282 Transcription factor WhiB; Region: Whib; pfam02467 593907003283 ParB-like nuclease domain; Region: ParBc; cl02129 593907003284 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 593907003285 Domain of unknown function (DUF955); Region: DUF955; cl01076 593907003286 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 593907003287 non-specific DNA binding site [nucleotide binding]; other site 593907003288 salt bridge; other site 593907003289 sequence-specific DNA binding site [nucleotide binding]; other site 593907003290 VacJ like lipoprotein; Region: VacJ; cl01073 593907003291 Phage integrase family; Region: Phage_integrase; pfam00589 593907003292 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 593907003293 DNA binding site [nucleotide binding] 593907003294 Int/Topo IB signature motif; other site 593907003295 active site 593907003296 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 593907003297 DNA binding residues [nucleotide binding] 593907003298 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 593907003299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 593907003300 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 593907003301 Predicted membrane protein [Function unknown]; Region: COG1511 593907003302 ABC-2 type transporter; Region: ABC2_membrane; cl11417 593907003303 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907003304 Walker A/P-loop; other site 593907003305 ATP binding site [chemical binding]; other site 593907003306 Q-loop/lid; other site 593907003307 ABC transporter signature motif; other site 593907003308 Walker B; other site 593907003309 D-loop; other site 593907003310 H-loop/switch region; other site 593907003311 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 593907003312 active site 593907003313 catalytic residues [active] 593907003314 metal binding site [ion binding]; metal-binding site 593907003315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 593907003316 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 593907003317 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 593907003318 Walker A/P-loop; other site 593907003319 ATP binding site [chemical binding]; other site 593907003320 Q-loop/lid; other site 593907003321 ABC transporter signature motif; other site 593907003322 Walker B; other site 593907003323 D-loop; other site 593907003324 H-loop/switch region; other site 593907003325 NIL domain; Region: NIL; pfam09383 593907003326 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907003327 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 593907003328 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 593907003329 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 593907003330 dimer interface [polypeptide binding]; other site 593907003331 active site 593907003332 Phosphopantetheine attachment site; Region: PP-binding; cl09936 593907003333 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 593907003334 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 593907003335 dimer interface [polypeptide binding]; other site 593907003336 active site 593907003337 CoA binding pocket [chemical binding]; other site 593907003338 Acyl transferase domain; Region: Acyl_transf_1; cl08282 593907003339 Acyl transferase domain; Region: Acyl_transf_1; cl08282 593907003340 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 593907003341 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 593907003342 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 593907003343 dimer interface [polypeptide binding]; other site 593907003344 TPP-binding site [chemical binding]; other site 593907003345 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 593907003346 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 593907003347 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 593907003348 dimer interface [polypeptide binding]; other site 593907003349 catalytic triad [active] 593907003350 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 593907003351 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 593907003352 dimer interface [polypeptide binding]; other site 593907003353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907003354 catalytic residue [active] 593907003355 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as...; Region: CBS_pair_PALP_assoc2; cd04609 593907003356 cystathionine gamma-synthase; Provisional; Region: PRK07811 593907003357 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 593907003358 homodimer interface [polypeptide binding]; other site 593907003359 substrate-cofactor binding pocket; other site 593907003360 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907003361 catalytic residue [active] 593907003362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3680 593907003363 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 593907003364 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 593907003365 MOSC domain; Region: MOSC; pfam03473 593907003366 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 593907003367 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 593907003368 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 593907003369 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 593907003370 Putative zinc ribbon domain; Region: DUF164; pfam02591 593907003371 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 593907003372 catalytic core [active] 593907003373 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 593907003374 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 593907003375 Protein of unknown function (DUF328); Region: DUF328; cl01143 593907003376 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 593907003377 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 593907003378 Copper resistance protein CopC; Region: CopC; cl01012 593907003379 Protein of unknown function (DUF817); Region: DUF817; cl01520 593907003380 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 593907003381 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 593907003382 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 593907003383 active site 593907003384 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 593907003385 oligomerization interface [polypeptide binding]; other site 593907003386 active site 593907003387 metal binding site [ion binding]; metal-binding site 593907003388 NAD synthetase; Provisional; Region: PRK13981 593907003389 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 593907003390 multimer interface [polypeptide binding]; other site 593907003391 active site 593907003392 catalytic triad [active] 593907003393 protein interface 1 [polypeptide binding]; other site 593907003394 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 593907003395 homodimer interface [polypeptide binding]; other site 593907003396 NAD binding pocket [chemical binding]; other site 593907003397 ATP binding pocket [chemical binding]; other site 593907003398 Mg binding site [ion binding]; other site 593907003399 active-site loop [active] 593907003400 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 593907003401 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 593907003402 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 593907003403 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 593907003404 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 593907003405 metal binding triad; other site 593907003406 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 593907003407 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 593907003408 metal binding triad; other site 593907003409 Domain of unknown function DUF20; Region: UPF0118; cl00465 593907003410 glutamine synthetase, type I; Region: GlnA; TIGR00653 593907003411 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 593907003412 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 593907003413 RDD family; Region: RDD; cl00746 593907003414 lipoyl synthase; Provisional; Region: PRK05481 593907003415 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 593907003416 FeS/SAM binding site; other site 593907003417 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 593907003418 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 593907003419 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 593907003420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907003421 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 593907003422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907003423 TIGR01777 family protein; Region: yfcH 593907003424 NAD(P) binding site [chemical binding]; other site 593907003425 active site 593907003426 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 593907003427 E3 interaction surface; other site 593907003428 lipoyl attachment site [posttranslational modification]; other site 593907003429 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 593907003430 E3 interaction surface; other site 593907003431 lipoyl attachment site [posttranslational modification]; other site 593907003432 e3 binding domain; Region: E3_binding; pfam02817 593907003433 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 593907003434 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 593907003435 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 593907003436 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 593907003437 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 593907003438 multifunctional aminopeptidase A; Provisional; Region: PRK00913 593907003439 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 593907003440 interface (dimer of trimers) [polypeptide binding]; other site 593907003441 Substrate-binding/catalytic site; other site 593907003442 Zn-binding sites [ion binding]; other site 593907003443 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 593907003444 quinone interaction residues [chemical binding]; other site 593907003445 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 593907003446 active site 593907003447 catalytic residues [active] 593907003448 FMN binding site [chemical binding]; other site 593907003449 substrate binding site [chemical binding]; other site 593907003450 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 593907003451 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 593907003452 DNA-binding site [nucleotide binding]; DNA binding site 593907003453 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 593907003454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907003455 homodimer interface [polypeptide binding]; other site 593907003456 catalytic residue [active] 593907003457 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 593907003458 Predicted membrane protein [Function unknown]; Region: COG2364 593907003459 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 593907003460 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 593907003461 active site 593907003462 catalytic tetrad [active] 593907003463 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 593907003464 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 593907003465 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 593907003466 active site 593907003467 metal binding site [ion binding]; metal-binding site 593907003468 dimer interface [polypeptide binding]; other site 593907003469 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 593907003470 active site 593907003471 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 593907003472 conserved cys residue [active] 593907003473 Quinolinate synthetase A protein; Region: NadA; cl00420 593907003474 Glycerate kinase family; Region: Gly_kinase; cl00841 593907003475 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 593907003476 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 593907003477 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 593907003478 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 593907003479 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 593907003480 D-pathway; other site 593907003481 Putative ubiquinol binding site [chemical binding]; other site 593907003482 Low-spin heme (heme b) binding site [chemical binding]; other site 593907003483 Putative water exit pathway; other site 593907003484 Binuclear center (heme o3/CuB) [ion binding]; other site 593907003485 K-pathway; other site 593907003486 Putative proton exit pathway; other site 593907003487 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 593907003488 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 593907003489 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 593907003490 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 593907003491 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 593907003492 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 593907003493 heme bH binding site [chemical binding]; other site 593907003494 intrachain domain interface; other site 593907003495 heme bL binding site [chemical binding]; other site 593907003496 interchain domain interface [polypeptide binding]; other site 593907003497 Qo binding site; other site 593907003498 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 593907003499 iron-sulfur cluster [ion binding]; other site 593907003500 [2Fe-2S] cluster binding site [ion binding]; other site 593907003501 Cytochrome c; Region: Cytochrom_C; cl11414 593907003502 Cytochrome c; Region: Cytochrom_C; cl11414 593907003503 Cytochrome c; Region: Cytochrom_C; cl11414 593907003504 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 593907003505 Subunit I/III interface [polypeptide binding]; other site 593907003506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 593907003507 active site 593907003508 phosphorylation site [posttranslational modification] 593907003509 intermolecular recognition site; other site 593907003510 dimerization interface [polypeptide binding]; other site 593907003511 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 593907003512 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 593907003513 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907003514 hypothetical protein; Validated; Region: PRK07883 593907003515 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 593907003516 active site 593907003517 substrate binding site [chemical binding]; other site 593907003518 catalytic site [active] 593907003519 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 593907003520 YacP-like NYN domain; Region: NYN_YacP; cl01491 593907003521 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 593907003522 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 593907003523 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 593907003524 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 593907003525 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 593907003526 putative acyl-acceptor binding pocket; other site 593907003527 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 593907003528 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 593907003529 active site 593907003530 ADP/pyrophosphate binding site [chemical binding]; other site 593907003531 allosteric effector site; other site 593907003532 dimerization interface [polypeptide binding]; other site 593907003533 fructose-1,6-bisphosphate binding site; other site 593907003534 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 593907003535 Catalytic domain of Protein Kinases; Region: PKc; cd00180 593907003536 active site 593907003537 ATP binding site [chemical binding]; other site 593907003538 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 593907003539 substrate binding site [chemical binding]; other site 593907003540 activation loop (A-loop); other site 593907003541 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 593907003542 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 593907003543 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 593907003544 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 593907003545 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 593907003546 putative peptidoglycan binding site; other site 593907003547 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 593907003548 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 593907003549 putative peptidoglycan binding site; other site 593907003550 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 593907003551 putative peptidoglycan binding site; other site 593907003552 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 593907003553 N-acetyl-D-glucosamine binding site [chemical binding]; other site 593907003554 catalytic residue [active] 593907003555 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 593907003556 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 593907003557 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 593907003558 substrate binding pocket [chemical binding]; other site 593907003559 chain length determination region; other site 593907003560 substrate-Mg2+ binding site; other site 593907003561 catalytic residues [active] 593907003562 aspartate-rich region 1; other site 593907003563 active site lid residues [active] 593907003564 aspartate-rich region 2; other site 593907003565 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 593907003566 Ligand Binding Site [chemical binding]; other site 593907003567 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 593907003568 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 593907003569 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 593907003570 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 593907003571 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 593907003572 DNA binding residues [nucleotide binding] 593907003573 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 593907003574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 593907003575 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 593907003576 anchoring element; other site 593907003577 dimer interface [polypeptide binding]; other site 593907003578 ATP binding site [chemical binding]; other site 593907003579 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 593907003580 active site 593907003581 metal binding site [ion binding]; metal-binding site 593907003582 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 593907003583 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 593907003584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907003585 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 593907003586 Coenzyme A binding pocket [chemical binding]; other site 593907003587 YhhN-like protein; Region: YhhN; cl01505 593907003588 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 593907003589 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 593907003590 CAP-like domain; other site 593907003591 Active site [active] 593907003592 primary dimer interface [polypeptide binding]; other site 593907003593 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 593907003594 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907003595 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 593907003596 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 593907003597 Sulfatase; Region: Sulfatase; cl10460 593907003598 Thymidine kinase; Region: TK; cl00631 593907003599 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 593907003600 Predicted membrane protein [Function unknown]; Region: COG2860 593907003601 UPF0126 domain; Region: UPF0126; pfam03458 593907003602 UPF0126 domain; Region: UPF0126; pfam03458 593907003603 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 593907003604 active site 593907003605 dimerization interface [polypeptide binding]; other site 593907003606 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 593907003607 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 593907003608 trimer interface [polypeptide binding]; other site 593907003609 active site 593907003610 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 593907003611 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 593907003612 ssDNA binding site; other site 593907003613 generic binding surface II; other site 593907003614 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 593907003615 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 593907003616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907003617 NAD(P) binding site [chemical binding]; other site 593907003618 active site 593907003619 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 593907003620 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 593907003621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907003622 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 593907003623 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 593907003624 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 593907003625 TRAM domain; Region: TRAM; cl01282 593907003626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 593907003627 aconitate hydratase; Validated; Region: PRK09277 593907003628 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 593907003629 substrate binding site [chemical binding]; other site 593907003630 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 593907003631 ligand binding site [chemical binding]; other site 593907003632 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 593907003633 substrate binding site [chemical binding]; other site 593907003634 Predicted flavoproteins [General function prediction only]; Region: COG2081 593907003635 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 593907003636 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 593907003637 TM1410 hypothetical-related protein; Region: DUF297; cl00997 593907003638 Phosphotransferase enzyme family; Region: APH; pfam01636 593907003639 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 593907003640 active site 593907003641 substrate binding site [chemical binding]; other site 593907003642 ATP binding site [chemical binding]; other site 593907003643 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 593907003644 putative active site [active] 593907003645 putative CoA binding site [chemical binding]; other site 593907003646 nudix motif; other site 593907003647 metal binding site [ion binding]; metal-binding site 593907003648 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 593907003649 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 593907003650 catalytic triad [active] 593907003651 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 593907003652 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 593907003653 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 593907003654 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 593907003655 active site 593907003656 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 593907003657 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 593907003658 TPP-binding site; other site 593907003659 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 593907003660 PYR/PP interface [polypeptide binding]; other site 593907003661 dimer interface [polypeptide binding]; other site 593907003662 TPP binding site [chemical binding]; other site 593907003663 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 593907003664 Pyruvate formate lyase 1; Region: PFL1; cd01678 593907003665 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 593907003666 coenzyme A binding site [chemical binding]; other site 593907003667 active site 593907003668 catalytic residues [active] 593907003669 glycine loop; other site 593907003670 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 593907003671 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 593907003672 FeS/SAM binding site; other site 593907003673 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 593907003674 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 593907003675 substrate binding site [chemical binding]; other site 593907003676 oxyanion hole (OAH) forming residues; other site 593907003677 trimer interface [polypeptide binding]; other site 593907003678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907003679 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 593907003680 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 593907003681 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 593907003682 dimer interface [polypeptide binding]; other site 593907003683 active site 593907003684 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 593907003685 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 593907003686 putative active site [active] 593907003687 catalytic site [active] 593907003688 putative substrate binding site [chemical binding]; other site 593907003689 HRDC domain; Region: HRDC; cl02578 593907003690 transcriptional regulator MalT; Provisional; Region: PRK04841 593907003691 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 593907003692 DNA binding residues [nucleotide binding] 593907003693 dimerization interface [polypeptide binding]; other site 593907003694 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 593907003695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907003696 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 593907003697 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 593907003698 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 593907003699 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 593907003700 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 593907003701 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 593907003702 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 593907003703 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 593907003704 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 593907003705 CysD dimerization site [polypeptide binding]; other site 593907003706 G1 box; other site 593907003707 putative GEF interaction site [polypeptide binding]; other site 593907003708 GTP/Mg2+ binding site [chemical binding]; other site 593907003709 Switch I region; other site 593907003710 G2 box; other site 593907003711 G3 box; other site 593907003712 Switch II region; other site 593907003713 G4 box; other site 593907003714 G5 box; other site 593907003715 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695 593907003716 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095 593907003717 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 593907003718 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 593907003719 Active Sites [active] 593907003720 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 593907003721 Active Sites [active] 593907003722 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 593907003723 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 593907003724 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 593907003725 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 593907003726 Proline dehydrogenase; Region: Pro_dh; cl03282 593907003727 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 593907003728 NAD(P) binding site [chemical binding]; other site 593907003729 catalytic residues [active] 593907003730 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 593907003731 Maltooligosyl trehalose synthase (MTSase) N-terminus domain. MTSase and maltooligosyl trehalose trehalohydrolase (MTHase) work together to produce trehalose. MTSase is responsible for converting the alpha-1,4-glucosidic linkage to an alpha,alpha-1,1-...; Region: MTHase_N_term; cd02853 593907003732 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 593907003733 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 593907003734 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 593907003735 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 593907003736 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 593907003737 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 593907003738 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 593907003739 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 593907003740 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 593907003741 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 593907003742 DXD motif; other site 593907003743 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 593907003744 Transcriptional regulators [Transcription]; Region: PurR; COG1609 593907003745 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 593907003746 DNA binding site [nucleotide binding] 593907003747 domain linker motif; other site 593907003748 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 593907003749 UbiA prenyltransferase family; Region: UbiA; cl00337 593907003750 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 593907003751 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 593907003752 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 593907003753 substrate binding pocket [chemical binding]; other site 593907003754 substrate-Mg2+ binding site; other site 593907003755 aspartate-rich region 1; other site 593907003756 aspartate-rich region 2; other site 593907003757 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 593907003758 substrate binding pocket [chemical binding]; other site 593907003759 chain length determination region; other site 593907003760 substrate-Mg2+ binding site; other site 593907003761 catalytic residues [active] 593907003762 aspartate-rich region 1; other site 593907003763 active site lid residues [active] 593907003764 aspartate-rich region 2; other site 593907003765 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and...; Region: IPP_Isomerase; cd02885 593907003766 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 593907003767 active site 593907003768 metal binding site [ion binding]; metal-binding site 593907003769 nudix motif; other site 593907003770 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907003771 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 593907003772 active site 593907003773 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 593907003774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 593907003775 Walker A motif; other site 593907003776 ATP binding site [chemical binding]; other site 593907003777 Walker B motif; other site 593907003778 arginine finger; other site 593907003779 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 593907003780 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 593907003781 substrate binding pocket [chemical binding]; other site 593907003782 membrane-bound complex binding site; other site 593907003783 hinge residues; other site 593907003784 chromosome segregation protein; Provisional; Region: PRK02224 593907003785 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 593907003786 Protein kinase domain; Region: Pkinase; pfam00069 593907003787 Catalytic domain of Protein Kinases; Region: PKc; cd00180 593907003788 active site 593907003789 ATP binding site [chemical binding]; other site 593907003790 substrate binding site [chemical binding]; other site 593907003791 activation loop (A-loop); other site 593907003792 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 593907003793 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 593907003794 metal ion-dependent adhesion site (MIDAS); other site 593907003795 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 593907003796 phosphopeptide binding site; other site 593907003797 Protein of unknown function DUF124; Region: DUF124; cl00884 593907003798 Protein of unknown function DUF124; Region: DUF124; cl00884 593907003799 Protein of unknown function DUF124; Region: DUF124; cl00884 593907003800 Transposase, Mutator family; Region: Transposase_mut; pfam00872 593907003801 MULE transposase domain; Region: MULE; pfam10551 593907003802 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 593907003803 Transposase; Region: DEDD_Tnp_IS110; pfam01548 593907003804 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 593907003805 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 593907003806 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 593907003807 putative dimer interface [polypeptide binding]; other site 593907003808 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 593907003809 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 593907003810 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 593907003811 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 593907003812 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 593907003813 NAD binding site [chemical binding]; other site 593907003814 catalytic Zn binding site [ion binding]; other site 593907003815 structural Zn binding site [ion binding]; other site 593907003816 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 593907003817 ATP binding site [chemical binding]; other site 593907003818 substrate binding site [chemical binding]; other site 593907003819 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 593907003820 catalytic core [active] 593907003821 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 593907003822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907003823 NAD(P) binding site [chemical binding]; other site 593907003824 active site 593907003825 Protein of unknown function DUF72; Region: DUF72; cl00777 593907003826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 593907003827 active site 593907003828 phosphorylation site [posttranslational modification] 593907003829 intermolecular recognition site; other site 593907003830 dimerization interface [polypeptide binding]; other site 593907003831 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 593907003832 DNA binding site [nucleotide binding] 593907003833 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 593907003834 dimer interface [polypeptide binding]; other site 593907003835 phosphorylation site [posttranslational modification] 593907003836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 593907003837 ATP binding site [chemical binding]; other site 593907003838 Mg2+ binding site [ion binding]; other site 593907003839 G-X-G motif; other site 593907003840 chorismate binding enzyme; Region: Chorismate_bind; cl10555 593907003841 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 593907003842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907003843 catalytic residue [active] 593907003844 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 593907003845 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 593907003846 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 593907003847 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 593907003848 active site 593907003849 dimer interface [polypeptide binding]; other site 593907003850 motif 1; other site 593907003851 motif 2; other site 593907003852 motif 3; other site 593907003853 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 593907003854 anticodon binding site; other site 593907003855 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 593907003856 nucleotide binding site/active site [active] 593907003857 HIT family signature motif; other site 593907003858 catalytic residue [active] 593907003859 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 593907003860 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 593907003861 putative acyl-acceptor binding pocket; other site 593907003862 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 593907003863 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 593907003864 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 593907003865 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 593907003866 active site 593907003867 multimer interface [polypeptide binding]; other site 593907003868 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 593907003869 nudix motif; other site 593907003870 aspartate aminotransferase; Provisional; Region: PRK08361 593907003871 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 593907003872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907003873 homodimer interface [polypeptide binding]; other site 593907003874 catalytic residue [active] 593907003875 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 593907003876 predicted active site [active] 593907003877 catalytic triad [active] 593907003878 Domain of unknown function DUF28; Region: DUF28; cl00361 593907003879 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 593907003880 active site 593907003881 putative DNA-binding cleft [nucleotide binding]; other site 593907003882 dimer interface [polypeptide binding]; other site 593907003883 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 593907003884 RuvA N terminal domain; Region: RuvA_N; pfam01330 593907003885 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 593907003886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 593907003887 Walker A motif; other site 593907003888 ATP binding site [chemical binding]; other site 593907003889 Walker B motif; other site 593907003890 arginine finger; other site 593907003891 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 593907003892 Preprotein translocase subunit; Region: YajC; cl00806 593907003893 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 593907003894 Protein export membrane protein; Region: SecD_SecF; cl14618 593907003895 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 593907003896 Protein export membrane protein; Region: SecD_SecF; cl14618 593907003897 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 593907003898 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 593907003899 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 593907003900 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 593907003901 synthetase active site [active] 593907003902 NTP binding site [chemical binding]; other site 593907003903 metal binding site [ion binding]; metal-binding site 593907003904 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 593907003905 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 593907003906 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 593907003907 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 593907003908 active site 593907003909 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 593907003910 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 593907003911 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 593907003912 dimer interface [polypeptide binding]; other site 593907003913 motif 1; other site 593907003914 active site 593907003915 motif 2; other site 593907003916 motif 3; other site 593907003917 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 593907003918 anticodon binding site; other site 593907003919 TspO/MBR family; Region: TspO_MBR; cl01379 593907003920 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 593907003921 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 593907003922 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 593907003923 dimer interface [polypeptide binding]; other site 593907003924 anticodon binding site; other site 593907003925 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 593907003926 homodimer interface [polypeptide binding]; other site 593907003927 motif 1; other site 593907003928 active site 593907003929 motif 2; other site 593907003930 GAD domain; Region: GAD; pfam02938 593907003931 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 593907003932 active site 593907003933 motif 3; other site 593907003934 MMPL family; Region: MMPL; pfam03176 593907003935 recombination factor protein RarA; Reviewed; Region: PRK13342 593907003936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 593907003937 Walker A motif; other site 593907003938 ATP binding site [chemical binding]; other site 593907003939 Walker B motif; other site 593907003940 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440 593907003941 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 593907003942 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 593907003943 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 593907003944 RNA binding surface [nucleotide binding]; other site 593907003945 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 593907003946 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 593907003947 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 593907003948 motif 1; other site 593907003949 active site 593907003950 motif 2; other site 593907003951 motif 3; other site 593907003952 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 593907003953 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 593907003954 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 593907003955 dimerization interface [polypeptide binding]; other site 593907003956 YceG-like family; Region: YceG; pfam02618 593907003957 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 593907003958 dimerization interface [polypeptide binding]; other site 593907003959 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 593907003960 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 593907003961 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 593907003962 shikimate binding site; other site 593907003963 NAD(P) binding site [chemical binding]; other site 593907003964 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 593907003965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 593907003966 active site 593907003967 phosphorylation site [posttranslational modification] 593907003968 intermolecular recognition site; other site 593907003969 dimerization interface [polypeptide binding]; other site 593907003970 ANTAR domain; Region: ANTAR; pfam03861 593907003971 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 593907003972 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 593907003973 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 593907003974 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 593907003975 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 593907003976 Walker A/P-loop; other site 593907003977 ATP binding site [chemical binding]; other site 593907003978 Q-loop/lid; other site 593907003979 ABC transporter signature motif; other site 593907003980 Walker B; other site 593907003981 D-loop; other site 593907003982 H-loop/switch region; other site 593907003983 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 593907003984 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 593907003985 Walker A/P-loop; other site 593907003986 ATP binding site [chemical binding]; other site 593907003987 Q-loop/lid; other site 593907003988 ABC transporter signature motif; other site 593907003989 Walker B; other site 593907003990 D-loop; other site 593907003991 H-loop/switch region; other site 593907003992 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 593907003993 TM-ABC transporter signature motif; other site 593907003994 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 593907003995 TM-ABC transporter signature motif; other site 593907003996 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 593907003997 5'-3' exonuclease; Region: 53EXOc; smart00475 593907003998 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 593907003999 active site 593907004000 metal binding site 1 [ion binding]; metal-binding site 593907004001 putative 5' ssDNA interaction site; other site 593907004002 metal binding site 3; metal-binding site 593907004003 metal binding site 2 [ion binding]; metal-binding site 593907004004 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 593907004005 putative DNA binding site [nucleotide binding]; other site 593907004006 putative metal binding site [ion binding]; other site 593907004007 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 593907004008 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 593907004009 active site 593907004010 DNA binding site [nucleotide binding] 593907004011 catalytic site [active] 593907004012 Protein of unknown function, DUF485; Region: DUF485; cl01231 593907004013 Sodium:solute symporter family; Region: SSF; cl00456 593907004014 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 593907004015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 593907004016 S-adenosylmethionine binding site [chemical binding]; other site 593907004017 6-phosphofructokinase; Provisional; Region: PRK03202 593907004018 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 593907004019 active site 593907004020 ADP/pyrophosphate binding site [chemical binding]; other site 593907004021 dimerization interface [polypeptide binding]; other site 593907004022 allosteric effector site; other site 593907004023 fructose-1,6-bisphosphate binding site; other site 593907004024 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 593907004025 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 593907004026 RNA binding site [nucleotide binding]; other site 593907004027 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 593907004028 RNA binding site [nucleotide binding]; other site 593907004029 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 593907004030 RNA binding site [nucleotide binding]; other site 593907004031 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 593907004032 RNA binding site [nucleotide binding]; other site 593907004033 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 593907004034 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 593907004035 CoA-binding site [chemical binding]; other site 593907004036 ATP-binding [chemical binding]; other site 593907004037 excinuclease ABC subunit B; Provisional; Region: PRK05298 593907004038 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 593907004039 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 593907004040 nucleotide binding region [chemical binding]; other site 593907004041 ATP-binding site [chemical binding]; other site 593907004042 Ultra-violet resistance protein B; Region: UvrB; pfam12344 593907004043 UvrB/uvrC motif; Region: UVR; pfam02151 593907004044 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 593907004045 Integral membrane protein TerC family; Region: TerC; cl10468 593907004046 YCII-related domain; Region: YCII; cl00999 593907004047 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 593907004048 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 593907004049 active site 593907004050 catalytic tetrad [active] 593907004051 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 593907004052 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 593907004053 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 593907004054 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 593907004055 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 593907004056 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 593907004057 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 593907004058 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 593907004059 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 593907004060 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 593907004061 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 593907004062 OsmC-like protein; Region: OsmC; cl00767 593907004063 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 593907004064 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 593907004065 UvrB/uvrC motif; Region: UVR; pfam02151 593907004066 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 593907004067 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 593907004068 P-loop ATPase protein family; Region: ATP_bind_2; cl10035 593907004069 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 593907004070 phosphate binding site [ion binding]; other site 593907004071 putative substrate binding pocket [chemical binding]; other site 593907004072 dimer interface [polypeptide binding]; other site 593907004073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 593907004074 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 593907004075 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907004076 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 593907004077 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 593907004078 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 593907004079 substrate binding site [chemical binding]; other site 593907004080 hinge regions; other site 593907004081 ADP binding site [chemical binding]; other site 593907004082 catalytic site [active] 593907004083 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 593907004084 substrate binding site [chemical binding]; other site 593907004085 dimer interface [polypeptide binding]; other site 593907004086 catalytic triad [active] 593907004087 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 593907004088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 593907004089 S-adenosylmethionine binding site [chemical binding]; other site 593907004090 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 593907004091 putative active site [active] 593907004092 opcA protein; Region: OpcA; TIGR00534 593907004093 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 593907004094 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 593907004095 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 593907004096 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 593907004097 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 593907004098 putative active site [active] 593907004099 catalytic residue [active] 593907004100 transketolase; Reviewed; Region: PRK05899 593907004101 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 593907004102 TPP-binding site [chemical binding]; other site 593907004103 dimer interface [polypeptide binding]; other site 593907004104 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 593907004105 PYR/PP interface [polypeptide binding]; other site 593907004106 dimer interface [polypeptide binding]; other site 593907004107 TPP binding site [chemical binding]; other site 593907004108 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 593907004109 UbiA prenyltransferase family; Region: UbiA; cl00337 593907004110 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 593907004111 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 593907004112 DNA binding site [nucleotide binding] 593907004113 Int/Topo IB signature motif; other site 593907004114 active site 593907004115 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 593907004116 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 593907004117 P-loop; other site 593907004118 Magnesium ion binding site [ion binding]; other site 593907004119 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 593907004120 Magnesium ion binding site [ion binding]; other site 593907004121 ScpA/B protein; Region: ScpA_ScpB; cl00598 593907004122 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 593907004123 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 593907004124 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 593907004125 RNA binding surface [nucleotide binding]; other site 593907004126 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 593907004127 active site 593907004128 prephenate dehydrogenase; Validated; Region: PRK06545 593907004129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907004130 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 593907004131 cytidylate kinase; Provisional; Region: cmk; PRK00023 593907004132 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 593907004133 CMP-binding site; other site 593907004134 The sites determining sugar specificity; other site 593907004135 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 593907004136 putative acyl-acceptor binding pocket; other site 593907004137 GTP-binding protein Der; Reviewed; Region: PRK03003 593907004138 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 593907004139 G1 box; other site 593907004140 GTP/Mg2+ binding site [chemical binding]; other site 593907004141 Switch I region; other site 593907004142 G2 box; other site 593907004143 Switch II region; other site 593907004144 G3 box; other site 593907004145 G4 box; other site 593907004146 G5 box; other site 593907004147 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 593907004148 G1 box; other site 593907004149 GTP/Mg2+ binding site [chemical binding]; other site 593907004150 Switch I region; other site 593907004151 G2 box; other site 593907004152 G3 box; other site 593907004153 Switch II region; other site 593907004154 G4 box; other site 593907004155 G5 box; other site 593907004156 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 593907004157 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907004158 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907004159 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 593907004160 Walker A/P-loop; other site 593907004161 ATP binding site [chemical binding]; other site 593907004162 Q-loop/lid; other site 593907004163 ABC transporter signature motif; other site 593907004164 Walker B; other site 593907004165 D-loop; other site 593907004166 H-loop/switch region; other site 593907004167 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 593907004168 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 593907004169 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 593907004170 putative metal binding site [ion binding]; other site 593907004171 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 593907004172 active site 593907004173 metal binding site [ion binding]; metal-binding site 593907004174 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 593907004175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907004176 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907004177 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These...; Region: Delta6-FADS-like; cd03506 593907004178 Fatty acid desaturase; Region: FA_desaturase; pfam00487 593907004179 putative di-iron ligands [ion binding]; other site 593907004180 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 593907004181 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 593907004182 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 593907004183 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 593907004184 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 593907004185 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 593907004186 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 593907004187 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 593907004188 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 593907004189 Ligand Binding Site [chemical binding]; other site 593907004190 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 593907004191 putative deacylase active site [active] 593907004192 Pirin-related protein [General function prediction only]; Region: COG1741 593907004193 Cupin domain; Region: Cupin_2; cl09118 593907004194 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 593907004195 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 593907004196 RNA polymerase sigma factor, SigZ family; Region: SigZ; TIGR02959 593907004197 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 593907004198 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 593907004199 DNA binding site [nucleotide binding] 593907004200 active site 593907004201 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 593907004202 Predicted dehydrogenase [General function prediction only]; Region: COG0579 593907004203 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 593907004204 Uncharacterized conserved protein (DUF2183); Region: DUF2183; cl02012 593907004205 Ferritin-like domain; Region: Ferritin; pfam00210 593907004206 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 593907004207 dimerization interface [polypeptide binding]; other site 593907004208 DPS ferroxidase diiron center [ion binding]; other site 593907004209 ion pore; other site 593907004210 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 593907004211 nucleotide binding site [chemical binding]; other site 593907004212 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 593907004213 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 593907004214 active site 593907004215 DNA binding site [nucleotide binding] 593907004216 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 593907004217 DNA binding site [nucleotide binding] 593907004218 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 593907004219 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 593907004220 putative DNA binding site [nucleotide binding]; other site 593907004221 putative homodimer interface [polypeptide binding]; other site 593907004222 hypothetical protein; Provisional; Region: PRK07945 593907004223 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 593907004224 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 593907004225 IHF dimer interface [polypeptide binding]; other site 593907004226 IHF - DNA interface [nucleotide binding]; other site 593907004227 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 593907004228 tetramer interface [polypeptide binding]; other site 593907004229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907004230 catalytic residue [active] 593907004231 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 593907004232 Cellulose binding domain; Region: CBM_2; cl02709 593907004233 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 593907004234 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 593907004235 Interdomain contacts; other site 593907004236 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 593907004237 Cellulose binding domain; Region: CBM_2; cl02709 593907004238 Transcriptional regulators [Transcription]; Region: PurR; COG1609 593907004239 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 593907004240 DNA binding site [nucleotide binding] 593907004241 domain linker motif; other site 593907004242 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 593907004243 dimerization interface [polypeptide binding]; other site 593907004244 ligand binding site [chemical binding]; other site 593907004245 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 593907004246 ligand binding site [chemical binding]; other site 593907004247 dimerization interface [polypeptide binding]; other site 593907004248 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 593907004249 PAS fold; Region: PAS_3; pfam08447 593907004250 putative active site [active] 593907004251 heme pocket [chemical binding]; other site 593907004252 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 593907004253 metal binding site [ion binding]; metal-binding site 593907004254 active site 593907004255 I-site; other site 593907004256 helicase 45; Provisional; Region: PTZ00424 593907004257 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 593907004258 ATP binding site [chemical binding]; other site 593907004259 Mg++ binding site [ion binding]; other site 593907004260 motif III; other site 593907004261 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 593907004262 nucleotide binding region [chemical binding]; other site 593907004263 ATP-binding site [chemical binding]; other site 593907004264 DbpA RNA binding domain; Region: DbpA; pfam03880 593907004265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907004266 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 593907004267 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 593907004268 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 593907004269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 593907004270 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 593907004271 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 593907004272 phosphopeptide binding site; other site 593907004273 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 593907004274 DNA binding residues [nucleotide binding] 593907004275 dimer interface [polypeptide binding]; other site 593907004276 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 593907004277 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 593907004278 DNA binding residues [nucleotide binding] 593907004279 putative dimer interface [polypeptide binding]; other site 593907004280 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 593907004281 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 593907004282 P loop; other site 593907004283 Nucleotide binding site [chemical binding]; other site 593907004284 DTAP/Switch II; other site 593907004285 Switch I; other site 593907004286 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 593907004287 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 593907004288 Coenzyme A binding pocket [chemical binding]; other site 593907004289 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 593907004290 active site 593907004291 metal binding site [ion binding]; metal-binding site 593907004292 DinB superfamily; Region: DinB_2; cl00986 593907004293 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907004294 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 593907004295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 593907004296 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 593907004297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 593907004298 active site 593907004299 phosphorylation site [posttranslational modification] 593907004300 intermolecular recognition site; other site 593907004301 dimerization interface [polypeptide binding]; other site 593907004302 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 593907004303 DNA binding residues [nucleotide binding] 593907004304 dimerization interface [polypeptide binding]; other site 593907004305 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 593907004306 DinB superfamily; Region: DinB_2; cl00986 593907004307 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 593907004308 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 593907004309 motif II; other site 593907004310 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 593907004311 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907004312 Walker A/P-loop; other site 593907004313 ATP binding site [chemical binding]; other site 593907004314 Q-loop/lid; other site 593907004315 ABC transporter signature motif; other site 593907004316 Walker B; other site 593907004317 D-loop; other site 593907004318 H-loop/switch region; other site 593907004319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 593907004320 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 593907004321 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 593907004322 putative DNA binding site [nucleotide binding]; other site 593907004323 putative Zn2+ binding site [ion binding]; other site 593907004324 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907004325 LysE type translocator; Region: LysE; cl00565 593907004326 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907004327 Alkylmercury lyase; Region: MerB; pfam03243 593907004328 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 593907004329 Integrase core domain; Region: rve; cl01316 593907004330 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 593907004331 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 593907004332 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 593907004333 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 593907004334 dimer interface [polypeptide binding]; other site 593907004335 Predicted transcriptional regulator [Transcription]; Region: COG2378 593907004336 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907004337 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907004338 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 593907004339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907004340 Coenzyme A binding pocket [chemical binding]; other site 593907004341 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 593907004342 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 593907004343 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 593907004344 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 593907004345 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 593907004346 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 593907004347 FAD binding domain; Region: FAD_binding_4; pfam01565 593907004348 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 593907004349 Ligand binding site [chemical binding]; other site 593907004350 Putative Catalytic site [active] 593907004351 DXD motif; other site 593907004352 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 593907004353 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 593907004354 putative active site [active] 593907004355 catalytic triad [active] 593907004356 putative dimer interface [polypeptide binding]; other site 593907004357 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 593907004358 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 593907004359 active site 593907004360 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 593907004361 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 593907004362 ATP binding site [chemical binding]; other site 593907004363 putative Mg++ binding site [ion binding]; other site 593907004364 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 593907004365 nucleotide binding region [chemical binding]; other site 593907004366 ATP-binding site [chemical binding]; other site 593907004367 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 593907004368 diacylglycerol kinase; Reviewed; Region: PRK11914 593907004369 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 593907004370 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 593907004371 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 593907004372 Predicted transcriptional regulator [Transcription]; Region: COG2378 593907004373 Predicted transcriptional regulator [Transcription]; Region: COG2378 593907004374 Predicted transcriptional regulator [Transcription]; Region: COG2378 593907004375 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 593907004376 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 593907004377 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 593907004378 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907004379 HisG, C-terminal domain; Region: HisG_C; cl06867 593907004380 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 593907004381 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 593907004382 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 593907004383 homopentamer interface [polypeptide binding]; other site 593907004384 active site 593907004385 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 593907004386 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 593907004387 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 593907004388 dimerization interface [polypeptide binding]; other site 593907004389 active site 593907004390 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 593907004391 Lumazine binding domain; Region: Lum_binding; pfam00677 593907004392 Lumazine binding domain; Region: Lum_binding; pfam00677 593907004393 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 593907004394 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 593907004395 catalytic motif [active] 593907004396 Zn binding site [ion binding]; other site 593907004397 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 593907004398 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 593907004399 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 593907004400 substrate binding site [chemical binding]; other site 593907004401 hexamer interface [polypeptide binding]; other site 593907004402 metal binding site [ion binding]; metal-binding site 593907004403 16S rRNA methyltransferase B; Provisional; Region: PRK14902 593907004404 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 593907004405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 593907004406 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 593907004407 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 593907004408 putative active site [active] 593907004409 substrate binding site [chemical binding]; other site 593907004410 putative cosubstrate binding site; other site 593907004411 catalytic site [active] 593907004412 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 593907004413 substrate binding site [chemical binding]; other site 593907004414 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 593907004415 motif II; other site 593907004416 primosome assembly protein PriA; Provisional; Region: PRK14873 593907004417 S-adenosylmethionine synthetase; Validated; Region: PRK05250 593907004418 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 593907004419 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 593907004420 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 593907004421 Flavoprotein; Region: Flavoprotein; cl08021 593907004422 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 593907004423 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 593907004424 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 593907004425 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 593907004426 catalytic site [active] 593907004427 G-X2-G-X-G-K; other site 593907004428 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 593907004429 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 593907004430 active site 593907004431 dimer interface [polypeptide binding]; other site 593907004432 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 593907004433 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 593907004434 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 593907004435 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 593907004436 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 593907004437 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 593907004438 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 593907004439 IMP binding site; other site 593907004440 dimer interface [polypeptide binding]; other site 593907004441 interdomain contacts; other site 593907004442 partial ornithine binding site; other site 593907004443 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 593907004444 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 593907004445 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 593907004446 catalytic site [active] 593907004447 subunit interface [polypeptide binding]; other site 593907004448 dihydroorotase; Validated; Region: pyrC; PRK09357 593907004449 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 593907004450 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 593907004451 active site 593907004452 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 593907004453 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 593907004454 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 593907004455 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 593907004456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 593907004457 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 593907004458 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 593907004459 active site 593907004460 catalytic residues [active] 593907004461 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 593907004462 active site 593907004463 catalytic residues [active] 593907004464 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 593907004465 metal binding site [ion binding]; metal-binding site 593907004466 active site 593907004467 I-site; other site 593907004468 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 593907004469 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 593907004470 putative RNA binding site [nucleotide binding]; other site 593907004471 elongation factor P; Validated; Region: PRK00529 593907004472 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 593907004473 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 593907004474 RNA binding site [nucleotide binding]; other site 593907004475 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 593907004476 RNA binding site [nucleotide binding]; other site 593907004477 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 593907004478 putative active site [active] 593907004479 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 593907004480 trimer interface [polypeptide binding]; other site 593907004481 active site 593907004482 dimer interface [polypeptide binding]; other site 593907004483 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 593907004484 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 593907004485 active site 593907004486 dimer interface [polypeptide binding]; other site 593907004487 metal binding site [ion binding]; metal-binding site 593907004488 shikimate kinase; Reviewed; Region: aroK; PRK00131 593907004489 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 593907004490 ADP binding site [chemical binding]; other site 593907004491 magnesium binding site [ion binding]; other site 593907004492 putative shikimate binding site; other site 593907004493 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 593907004494 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 593907004495 Interdomain contacts; other site 593907004496 Cytokine receptor motif; other site 593907004497 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 593907004498 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 593907004499 Interdomain contacts; other site 593907004500 Cytokine receptor motif; other site 593907004501 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 593907004502 Tetramer interface [polypeptide binding]; other site 593907004503 Active site [active] 593907004504 FMN-binding site [chemical binding]; other site 593907004505 Cell division protein FtsA; Region: FtsA; cl11496 593907004506 Competence protein A; Region: Competence_A; pfam11104 593907004507 Cell division protein FtsA; Region: FtsA; cl11496 593907004508 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 593907004509 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 593907004510 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 593907004511 Protein of unknown function (DUF342); Region: DUF342; pfam03961 593907004512 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 593907004513 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 593907004514 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 593907004515 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 593907004516 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 593907004517 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 593907004518 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 593907004519 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 593907004520 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 593907004521 Walker A motif; other site 593907004522 ATP binding site [chemical binding]; other site 593907004523 Walker B motif; other site 593907004524 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 593907004525 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 593907004526 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 593907004527 Walker A motif; other site 593907004528 ATP binding site [chemical binding]; other site 593907004529 Walker B motif; other site 593907004530 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 593907004531 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 593907004532 pyruvate kinase; Provisional; Region: PRK06247 593907004533 domain interfaces; other site 593907004534 active site 593907004535 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 593907004536 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 593907004537 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 593907004538 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 593907004539 active site 593907004540 dimer interface [polypeptide binding]; other site 593907004541 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 593907004542 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 593907004543 active site 593907004544 FMN binding site [chemical binding]; other site 593907004545 substrate binding site [chemical binding]; other site 593907004546 3Fe-4S cluster binding site [ion binding]; other site 593907004547 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 593907004548 domain interface; other site 593907004549 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 593907004550 tryptophan synthase; Region: PLN02591 593907004551 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 593907004552 substrate binding site [chemical binding]; other site 593907004553 active site 593907004554 catalytic residues [active] 593907004555 heterodimer interface [polypeptide binding]; other site 593907004556 tryptophan synthase, beta chain; Region: PLN02618 593907004557 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 593907004558 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907004559 catalytic residue [active] 593907004560 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 593907004561 active site 593907004562 ribulose/triose binding site [chemical binding]; other site 593907004563 phosphate binding site [ion binding]; other site 593907004564 substrate (anthranilate) binding pocket [chemical binding]; other site 593907004565 product (indole) binding pocket [chemical binding]; other site 593907004566 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 593907004567 Interferon-induced transmembrane protein; Region: CD225; pfam04505 593907004568 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 593907004569 anthranilate synthase component I; Provisional; Region: PRK13571 593907004570 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 593907004571 chorismate binding enzyme; Region: Chorismate_bind; cl10555 593907004572 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 593907004573 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 593907004574 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 593907004575 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907004576 Walker A/P-loop; other site 593907004577 ATP binding site [chemical binding]; other site 593907004578 Q-loop/lid; other site 593907004579 ABC transporter signature motif; other site 593907004580 Walker B; other site 593907004581 D-loop; other site 593907004582 H-loop/switch region; other site 593907004583 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 593907004584 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 593907004585 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907004586 ATP binding site [chemical binding]; other site 593907004587 Q-loop/lid; other site 593907004588 ABC transporter signature motif; other site 593907004589 Walker B; other site 593907004590 D-loop; other site 593907004591 H-loop/switch region; other site 593907004592 TIGR03085 family protein; Region: TIGR03085 593907004593 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 593907004594 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 593907004595 substrate binding site [chemical binding]; other site 593907004596 glutamase interaction surface [polypeptide binding]; other site 593907004597 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 593907004598 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 593907004599 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 593907004600 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded...; Region: proteasome_protease_HslV; cd01906 593907004601 active site 593907004602 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded...; Region: proteasome_protease_HslV; cd01906 593907004603 active site 593907004604 Pup-like protein; Region: Pup; cl05289 593907004605 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 593907004606 Pup-ligase protein; Region: Pup_ligase; pfam03136 593907004607 proteasome ATPase; Region: pup_AAA; TIGR03689 593907004608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 593907004609 Walker A motif; other site 593907004610 ATP binding site [chemical binding]; other site 593907004611 Walker B motif; other site 593907004612 arginine finger; other site 593907004613 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 593907004614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 593907004615 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 593907004616 active site 593907004617 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 593907004618 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 593907004619 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 593907004620 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 593907004621 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 593907004622 motif II; other site 593907004623 PAC2 family; Region: PAC2; cl00847 593907004624 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 593907004625 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 593907004626 active site 593907004627 HIGH motif; other site 593907004628 nucleotide binding site [chemical binding]; other site 593907004629 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 593907004630 active site 593907004631 KMSKS motif; other site 593907004632 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 593907004633 putative tRNA binding surface [nucleotide binding]; other site 593907004634 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 593907004635 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 593907004636 Bacitracin resistance protein BacA; Region: BacA; cl00858 593907004637 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 593907004638 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 593907004639 active site 593907004640 catalytic tetrad [active] 593907004641 hypothetical protein; Provisional; Region: PRK07906 593907004642 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 593907004643 putative metal binding site [ion binding]; other site 593907004644 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 593907004645 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 593907004646 active site 593907004647 Zn binding site [ion binding]; other site 593907004648 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406 593907004649 NAD(P) binding site [chemical binding]; other site 593907004650 substrate binding site [chemical binding]; other site 593907004651 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 593907004652 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 593907004653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907004654 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 593907004655 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 593907004656 Domain of unknown function DUF20; Region: UPF0118; cl00465 593907004657 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 593907004658 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 593907004659 Int/Topo IB signature motif; other site 593907004660 active site 593907004661 catalytic residues [active] 593907004662 DNA binding site [nucleotide binding] 593907004663 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 593907004664 Transposase; Region: DDE_Tnp_ISL3; pfam01610 593907004665 VanW like protein; Region: VanW; pfam04294 593907004666 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 593907004667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 593907004668 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 593907004669 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 593907004670 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 593907004671 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 593907004672 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 593907004673 active site 593907004674 DNA binding site [nucleotide binding] 593907004675 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 593907004676 DNA binding site [nucleotide binding] 593907004677 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 593907004678 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 593907004679 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 593907004680 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 593907004681 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 593907004682 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 593907004683 generic binding surface I; other site 593907004684 generic binding surface II; other site 593907004685 Y-family of DNA polymerases; Region: PolY; cl12025 593907004686 active site 593907004687 DNA binding site [nucleotide binding] 593907004688 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 593907004689 dimerization interface [polypeptide binding]; other site 593907004690 putative DNA binding site [nucleotide binding]; other site 593907004691 putative Zn2+ binding site [ion binding]; other site 593907004692 putative transporter; Provisional; Region: PRK11660 593907004693 Sulfate transporter family; Region: Sulfate_transp; cl00967 593907004694 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 593907004695 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 593907004696 substrate binding site [chemical binding]; other site 593907004697 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 593907004698 putative deacylase active site [active] 593907004699 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 593907004700 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 593907004701 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 593907004702 Chitin binding domain; Region: Chitin_bind_3; cl03871 593907004703 Cellulose binding domain; Region: CBM_2; cl02709 593907004704 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 593907004705 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 593907004706 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 593907004707 Walker A/P-loop; other site 593907004708 ATP binding site [chemical binding]; other site 593907004709 Q-loop/lid; other site 593907004710 ABC transporter signature motif; other site 593907004711 Walker B; other site 593907004712 D-loop; other site 593907004713 H-loop/switch region; other site 593907004714 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 593907004715 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 593907004716 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907004717 Walker A/P-loop; other site 593907004718 ATP binding site [chemical binding]; other site 593907004719 Q-loop/lid; other site 593907004720 ABC transporter signature motif; other site 593907004721 Walker B; other site 593907004722 D-loop; other site 593907004723 H-loop/switch region; other site 593907004724 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 593907004725 HflK protein; Region: hflK; TIGR01933 593907004726 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 593907004727 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 593907004728 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 593907004729 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907004730 Walker A/P-loop; other site 593907004731 ATP binding site [chemical binding]; other site 593907004732 Q-loop/lid; other site 593907004733 ABC transporter signature motif; other site 593907004734 Walker B; other site 593907004735 D-loop; other site 593907004736 H-loop/switch region; other site 593907004737 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 593907004738 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 593907004739 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 593907004740 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 593907004741 ligand binding site [chemical binding]; other site 593907004742 oligomer interface [polypeptide binding]; other site 593907004743 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 593907004744 dimer interface [polypeptide binding]; other site 593907004745 N-terminal domain interface [polypeptide binding]; other site 593907004746 sulfate 1 binding site; other site 593907004747 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 593907004748 catalytic core [active] 593907004749 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 593907004750 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907004751 NAD(P) binding site [chemical binding]; other site 593907004752 active site 593907004753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907004754 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 593907004755 NAD(P) binding site [chemical binding]; other site 593907004756 active site 593907004757 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 593907004758 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 593907004759 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 593907004760 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 593907004761 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907004762 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 593907004763 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 593907004764 BioY family; Region: BioY; cl00560 593907004765 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 593907004766 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 593907004767 Walker A/P-loop; other site 593907004768 ATP binding site [chemical binding]; other site 593907004769 Q-loop/lid; other site 593907004770 ABC transporter signature motif; other site 593907004771 Walker B; other site 593907004772 D-loop; other site 593907004773 H-loop/switch region; other site 593907004774 Cobalt transport protein; Region: CbiQ; cl00463 593907004775 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 593907004776 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 593907004777 putative metal binding site [ion binding]; other site 593907004778 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 593907004779 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 593907004780 putative sugar binding sites [chemical binding]; other site 593907004781 Q-X-W motif; other site 593907004782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907004783 Domain of unknown function DUF59; Region: DUF59; cl00941 593907004784 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 593907004785 trimerization site [polypeptide binding]; other site 593907004786 active site 593907004787 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 593907004788 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 593907004789 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 593907004790 catalytic residue [active] 593907004791 FeS assembly ATPase SufC; Region: sufC; TIGR01978 593907004792 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 593907004793 Walker A/P-loop; other site 593907004794 ATP binding site [chemical binding]; other site 593907004795 Q-loop/lid; other site 593907004796 ABC transporter signature motif; other site 593907004797 Walker B; other site 593907004798 D-loop; other site 593907004799 H-loop/switch region; other site 593907004800 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise...; Region: Rieske_RO_ferredoxin; cd03528 593907004801 [2Fe-2S] cluster binding site [ion binding]; other site 593907004802 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 593907004803 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 593907004804 FeS assembly protein SufB; Region: sufB; TIGR01980 593907004805 Predicted transcriptional regulator [Transcription]; Region: COG2345 593907004806 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907004807 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 593907004808 Integrase core domain; Region: rve; cl01316 593907004809 PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 593907004810 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 593907004811 Walker A/P-loop; other site 593907004812 ATP binding site [chemical binding]; other site 593907004813 Q-loop/lid; other site 593907004814 ABC transporter signature motif; other site 593907004815 Walker B; other site 593907004816 D-loop; other site 593907004817 H-loop/switch region; other site 593907004818 ABC-2 type transporter; Region: ABC2_membrane; cl11417 593907004819 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 593907004820 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 593907004821 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907004822 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 593907004823 Walker A/P-loop; other site 593907004824 ATP binding site [chemical binding]; other site 593907004825 Q-loop/lid; other site 593907004826 ABC transporter signature motif; other site 593907004827 Walker B; other site 593907004828 D-loop; other site 593907004829 H-loop/switch region; other site 593907004830 ABC-2 type transporter; Region: ABC2_membrane; cl11417 593907004831 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 593907004832 dimer interface [polypeptide binding]; other site 593907004833 ADP-ribose binding site [chemical binding]; other site 593907004834 active site 593907004835 nudix motif; other site 593907004836 metal binding site [ion binding]; metal-binding site 593907004837 CTP synthetase; Validated; Region: pyrG; PRK05380 593907004838 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 593907004839 Catalytic site [active] 593907004840 Active site [active] 593907004841 UTP binding site [chemical binding]; other site 593907004842 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 593907004843 active site 593907004844 putative oxyanion hole; other site 593907004845 catalytic triad [active] 593907004846 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 593907004847 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 593907004848 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 593907004849 Thiamine pyrophosphokinase; Region: TPK; cl09135 593907004850 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 593907004851 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 593907004852 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907004853 Walker A/P-loop; other site 593907004854 ATP binding site [chemical binding]; other site 593907004855 Q-loop/lid; other site 593907004856 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 593907004857 ABC transporter signature motif; other site 593907004858 Walker B; other site 593907004859 D-loop; other site 593907004860 H-loop/switch region; other site 593907004861 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 593907004862 ATP-NAD kinase; Region: NAD_kinase; pfam01513 593907004863 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 593907004864 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 593907004865 RNA binding surface [nucleotide binding]; other site 593907004866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 593907004867 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 593907004868 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 593907004869 active site 593907004870 motif I; other site 593907004871 motif II; other site 593907004872 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 593907004873 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 593907004874 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 593907004875 active site 593907004876 HIGH motif; other site 593907004877 dimer interface [polypeptide binding]; other site 593907004878 KMSKS motif; other site 593907004879 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 593907004880 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 593907004881 active site 593907004882 DNA binding site [nucleotide binding] 593907004883 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907004884 Active site [active] 593907004885 argininosuccinate lyase; Provisional; Region: PRK00855 593907004886 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 593907004887 active sites [active] 593907004888 tetramer interface [polypeptide binding]; other site 593907004889 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 593907004890 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 593907004891 ANP binding site [chemical binding]; other site 593907004892 Substrate Binding Site II [chemical binding]; other site 593907004893 Substrate Binding Site I [chemical binding]; other site 593907004894 arginine repressor; Provisional; Region: PRK04280 593907004895 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 593907004896 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 593907004897 ornithine carbamoyltransferase; Provisional; Region: PRK00779 593907004898 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 593907004899 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 593907004900 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 593907004901 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 593907004902 inhibitor-cofactor binding pocket; inhibition site 593907004903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907004904 catalytic residue [active] 593907004905 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250 593907004906 feedback inhibition sensing region; other site 593907004907 homohexameric interface [polypeptide binding]; other site 593907004908 nucleotide binding site [chemical binding]; other site 593907004909 N-acetyl-L-glutamate binding site [chemical binding]; other site 593907004910 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 593907004911 heterotetramer interface [polypeptide binding]; other site 593907004912 active site pocket [active] 593907004913 cleavage site 593907004914 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 593907004915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907004916 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 593907004917 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 593907004918 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 593907004919 NADP binding site [chemical binding]; other site 593907004920 dimer interface [polypeptide binding]; other site 593907004921 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 593907004922 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 593907004923 catalytic residues [active] 593907004924 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 593907004925 active site 593907004926 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 593907004927 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 593907004928 catalytic residue [active] 593907004929 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 593907004930 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 593907004931 generic binding surface I; other site 593907004932 generic binding surface II; other site 593907004933 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 593907004934 putative active site [active] 593907004935 putative catalytic site [active] 593907004936 putative Mg binding site IVb [ion binding]; other site 593907004937 putative phosphate binding site [ion binding]; other site 593907004938 putative DNA binding site [nucleotide binding]; other site 593907004939 putative Mg binding site IVa [ion binding]; other site 593907004940 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 593907004941 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 593907004942 active site 593907004943 metal binding site [ion binding]; metal-binding site 593907004944 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 593907004945 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 593907004946 active site 593907004947 metal binding site [ion binding]; metal-binding site 593907004948 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 593907004949 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 593907004950 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 593907004951 putative tRNA-binding site [nucleotide binding]; other site 593907004952 B3/4 domain; Region: B3_4; cl11458 593907004953 tRNA synthetase B5 domain; Region: B5; cl08394 593907004954 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 593907004955 dimer interface [polypeptide binding]; other site 593907004956 motif 1; other site 593907004957 motif 3; other site 593907004958 motif 2; other site 593907004959 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 593907004960 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 593907004961 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 593907004962 dimer interface [polypeptide binding]; other site 593907004963 motif 1; other site 593907004964 active site 593907004965 motif 2; other site 593907004966 motif 3; other site 593907004967 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 593907004968 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 593907004969 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 593907004970 23S rRNA binding site [nucleotide binding]; other site 593907004971 L21 binding site [polypeptide binding]; other site 593907004972 L13 binding site [polypeptide binding]; other site 593907004973 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 593907004974 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 593907004975 metal binding site 2 [ion binding]; metal-binding site 593907004976 putative DNA binding helix; other site 593907004977 metal binding site 1 [ion binding]; metal-binding site 593907004978 dimer interface [polypeptide binding]; other site 593907004979 structural Zn2+ binding site [ion binding]; other site 593907004980 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 593907004981 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 593907004982 tetramer interface [polypeptide binding]; other site 593907004983 heme binding pocket [chemical binding]; other site 593907004984 NADPH binding site [chemical binding]; other site 593907004985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 593907004986 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 593907004987 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 593907004988 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 593907004989 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 593907004990 catalytic residues [active] 593907004991 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 593907004992 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 593907004993 putative active site [active] 593907004994 oxyanion strand; other site 593907004995 catalytic triad [active] 593907004996 RNA polymerase sigma factor; Provisional; Region: PRK11924 593907004997 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 593907004998 putative active site pocket [active] 593907004999 4-fold oligomerization interface [polypeptide binding]; other site 593907005000 metal binding residues [ion binding]; metal-binding site 593907005001 3-fold/trimer interface [polypeptide binding]; other site 593907005002 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 593907005003 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 593907005004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907005005 homodimer interface [polypeptide binding]; other site 593907005006 catalytic residue [active] 593907005007 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 593907005008 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 593907005009 NAD binding site [chemical binding]; other site 593907005010 dimerization interface [polypeptide binding]; other site 593907005011 product binding site; other site 593907005012 substrate binding site [chemical binding]; other site 593907005013 zinc binding site [ion binding]; other site 593907005014 catalytic residues [active] 593907005015 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 593907005016 RNA binding surface [nucleotide binding]; other site 593907005017 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 593907005018 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 593907005019 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 593907005020 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 593907005021 generic binding surface II; other site 593907005022 generic binding surface I; other site 593907005023 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 593907005024 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 593907005025 active site 593907005026 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 593907005027 lipoprotein signal peptidase; Provisional; Region: PRK14787 593907005028 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 593907005029 DivIVA protein; Region: DivIVA; pfam05103 593907005030 DivIVA domain; Region: DivI1A_domain; TIGR03544 593907005031 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 593907005032 Protein of unknown function (DUF552); Region: DUF552; cl00775 593907005033 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 593907005034 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 593907005035 nucleotide binding site [chemical binding]; other site 593907005036 SulA interaction site; other site 593907005037 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 593907005038 Cell division protein FtsQ; Region: FtsQ; pfam03799 593907005039 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 593907005040 active site 593907005041 homodimer interface [polypeptide binding]; other site 593907005042 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 593907005043 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 593907005044 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 593907005045 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 593907005046 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 593907005047 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 593907005048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907005049 NAD(P) binding pocket [chemical binding]; other site 593907005050 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 593907005051 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 593907005052 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 593907005053 Mg++ binding site [ion binding]; other site 593907005054 putative catalytic motif [active] 593907005055 putative substrate binding site [chemical binding]; other site 593907005056 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 593907005057 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 593907005058 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 593907005059 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 593907005060 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 593907005061 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 593907005062 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 593907005063 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 593907005064 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 593907005065 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 593907005066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 593907005067 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 593907005068 cell division protein MraZ; Reviewed; Region: PRK00326 593907005069 MraZ protein; Region: MraZ; pfam02381 593907005070 MraZ protein; Region: MraZ; pfam02381 593907005071 MoxR-like ATPases [General function prediction only]; Region: COG0714 593907005072 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 593907005073 ATP binding site [chemical binding]; other site 593907005074 Walker A motif; other site 593907005075 Walker B motif; other site 593907005076 arginine finger; other site 593907005077 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907005078 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 593907005079 Protein of unknown function DUF58; Region: DUF58; pfam01882 593907005080 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 593907005081 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 593907005082 DNA polymerase IV; Validated; Region: PRK03858 593907005083 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 593907005084 active site 593907005085 DNA binding site [nucleotide binding] 593907005086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 593907005087 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 593907005088 DNA-binding site [nucleotide binding]; DNA binding site 593907005089 RNA-binding motif; other site 593907005090 PAC2 family; Region: PAC2; cl00847 593907005091 Response regulator receiver domain; Region: Response_reg; pfam00072 593907005092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 593907005093 active site 593907005094 phosphorylation site [posttranslational modification] 593907005095 intermolecular recognition site; other site 593907005096 dimerization interface [polypeptide binding]; other site 593907005097 CHASE3 domain; Region: CHASE3; cl05000 593907005098 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 593907005099 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 593907005100 dimer interface [polypeptide binding]; other site 593907005101 phosphorylation site [posttranslational modification] 593907005102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 593907005103 ATP binding site [chemical binding]; other site 593907005104 Mg2+ binding site [ion binding]; other site 593907005105 G-X-G motif; other site 593907005106 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 593907005107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 593907005108 active site 593907005109 phosphorylation site [posttranslational modification] 593907005110 intermolecular recognition site; other site 593907005111 dimerization interface [polypeptide binding]; other site 593907005112 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 593907005113 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 593907005114 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 593907005115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907005116 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 593907005117 L-serine binding site [chemical binding]; other site 593907005118 ACT domain interface; other site 593907005119 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 593907005120 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 593907005121 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 593907005122 ATP cone domain; Region: ATP-cone; pfam03477 593907005123 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 593907005124 putative peptidoglycan binding site; other site 593907005125 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907005126 LexA repressor; Validated; Region: PRK00215 593907005127 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 593907005128 Catalytic site [active] 593907005129 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406 593907005130 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 593907005131 NAD(P) binding site [chemical binding]; other site 593907005132 LDH/MDH dimer interface [polypeptide binding]; other site 593907005133 substrate binding site [chemical binding]; other site 593907005134 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 593907005135 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 593907005136 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 593907005137 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250 593907005138 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 593907005139 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 593907005140 G1 box; other site 593907005141 GTP/Mg2+ binding site [chemical binding]; other site 593907005142 Switch I region; other site 593907005143 G2 box; other site 593907005144 G3 box; other site 593907005145 Switch II region; other site 593907005146 G4 box; other site 593907005147 G5 box; other site 593907005148 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 593907005149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 593907005150 S-adenosylmethionine binding site [chemical binding]; other site 593907005151 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 593907005152 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 593907005153 catalytic residues [active] 593907005154 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 593907005155 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 593907005156 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 593907005157 IPP transferase; Region: IPPT; cl00403 593907005158 HSP90 family protein; Provisional; Region: PRK14083 593907005159 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 593907005160 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 593907005161 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 593907005162 FeS/SAM binding site; other site 593907005163 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 593907005164 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 593907005165 Walker A/P-loop; other site 593907005166 ATP binding site [chemical binding]; other site 593907005167 Q-loop/lid; other site 593907005168 ABC transporter signature motif; other site 593907005169 Walker B; other site 593907005170 D-loop; other site 593907005171 H-loop/switch region; other site 593907005172 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 593907005173 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 593907005174 substrate binding pocket [chemical binding]; other site 593907005175 membrane-bound complex binding site; other site 593907005176 hinge residues; other site 593907005177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907005178 dimer interface [polypeptide binding]; other site 593907005179 conserved gate region; other site 593907005180 putative PBP binding loops; other site 593907005181 ABC-ATPase subunit interface; other site 593907005182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907005183 dimer interface [polypeptide binding]; other site 593907005184 conserved gate region; other site 593907005185 putative PBP binding loops; other site 593907005186 ABC-ATPase subunit interface; other site 593907005187 phosphodiesterase; Provisional; Region: PRK12704 593907005188 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 593907005189 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 593907005190 RecX family; Region: RecX; cl00936 593907005191 recombinase A; Provisional; Region: recA; PRK09354 593907005192 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 593907005193 hexamer interface [polypeptide binding]; other site 593907005194 Walker A motif; other site 593907005195 ATP binding site [chemical binding]; other site 593907005196 Walker B motif; other site 593907005197 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 593907005198 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 593907005199 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 593907005200 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 593907005201 ATP binding site [chemical binding]; other site 593907005202 putative Mg++ binding site [ion binding]; other site 593907005203 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 593907005204 nucleotide binding region [chemical binding]; other site 593907005205 ATP-binding site [chemical binding]; other site 593907005206 DEAD/H associated; Region: DEAD_assoc; pfam08494 593907005207 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 593907005208 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 593907005209 putative DNA binding site [nucleotide binding]; other site 593907005210 catalytic residue [active] 593907005211 putative H2TH interface [polypeptide binding]; other site 593907005212 putative catalytic residues [active] 593907005213 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 593907005214 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 593907005215 non-specific DNA binding site [nucleotide binding]; other site 593907005216 salt bridge; other site 593907005217 sequence-specific DNA binding site [nucleotide binding]; other site 593907005218 Competence-damaged protein; Region: CinA; cl00666 593907005219 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 593907005220 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 593907005221 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 593907005222 putative active site [active] 593907005223 putative metal binding site [ion binding]; other site 593907005224 putative diguanylate cyclase; Provisional; Region: PRK09776 593907005225 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 593907005226 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 593907005227 metal binding site [ion binding]; metal-binding site 593907005228 active site 593907005229 I-site; other site 593907005230 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 593907005231 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907005232 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 593907005233 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 593907005234 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 593907005235 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 593907005236 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 593907005237 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 593907005238 dimer interface [polypeptide binding]; other site 593907005239 active site 593907005240 catalytic residue [active] 593907005241 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 593907005242 NADP+ binding site [chemical binding]; other site 593907005243 folate binding site [chemical binding]; other site 593907005244 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 593907005245 dimerization interface [polypeptide binding]; other site 593907005246 active site 593907005247 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 593907005248 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 593907005249 tetramerization interface [polypeptide binding]; other site 593907005250 NAD(P) binding site [chemical binding]; other site 593907005251 catalytic residues [active] 593907005252 AzlC protein; Region: AzlC; cl00570 593907005253 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907005254 dihydrodipicolinate reductase; Provisional; Region: PRK00048 593907005255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907005256 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 593907005257 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 593907005258 active site 593907005259 catalytic residues [active] 593907005260 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 593907005261 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 593907005262 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 593907005263 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 593907005264 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 593907005265 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 593907005266 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 593907005267 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 593907005268 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 593907005269 putative nucleic acid binding region [nucleotide binding]; other site 593907005270 G-X-X-G motif; other site 593907005271 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 593907005272 RNA binding site [nucleotide binding]; other site 593907005273 domain interface; other site 593907005274 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 593907005275 16S/18S rRNA binding site [nucleotide binding]; other site 593907005276 S13e-L30e interaction site [polypeptide binding]; other site 593907005277 25S rRNA binding site [nucleotide binding]; other site 593907005278 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 593907005279 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 593907005280 active site 593907005281 Riboflavin kinase; Region: Flavokinase; pfam01687 593907005282 Cellulase N-terminus domain. Cellulases are O-glycosyl hydrolases (GHs) that hydrolyze beta 1-4 glucosidic bonds in cellulose. They are usually catagorized into either exoglucanases which sequentially release sugar units from the cellulose chain and...; Region: Cellulase_N_term; cd02850 593907005283 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 593907005284 Immunoglobulin domain; Region: Ig; cl11960 593907005285 Immunoglobulin domain; Region: Ig; cl11960 593907005286 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 593907005287 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 593907005288 RNA binding site [nucleotide binding]; other site 593907005289 active site 593907005290 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 593907005291 Predicted transcriptional regulator with C-terminal CBS domains [Transcription]; Region: COG3620 593907005292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 593907005293 putative substrate translocation pore; other site 593907005294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 593907005295 Ribosome-binding factor A; Region: RBFA; cl00542 593907005296 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 593907005297 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 593907005298 translation initiation factor IF-2; Region: IF-2; TIGR00487 593907005299 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 593907005300 G1 box; other site 593907005301 putative GEF interaction site [polypeptide binding]; other site 593907005302 GTP/Mg2+ binding site [chemical binding]; other site 593907005303 Switch I region; other site 593907005304 G2 box; other site 593907005305 G3 box; other site 593907005306 Switch II region; other site 593907005307 G4 box; other site 593907005308 G5 box; other site 593907005309 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 593907005310 Translation-initiation factor 2; Region: IF-2; pfam11987 593907005311 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 593907005312 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 593907005313 NusA N-terminal domain; Region: NusA_N; pfam08529 593907005314 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 593907005315 RNA binding site [nucleotide binding]; other site 593907005316 homodimer interface [polypeptide binding]; other site 593907005317 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 593907005318 G-X-X-G motif; other site 593907005319 ribosome maturation protein RimP; Reviewed; Region: PRK00092 593907005320 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 593907005321 prolyl-tRNA synthetase; Provisional; Region: PRK09194 593907005322 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 593907005323 dimer interface [polypeptide binding]; other site 593907005324 motif 1; other site 593907005325 active site 593907005326 motif 2; other site 593907005327 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 593907005328 putative deacylase active site [active] 593907005329 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 593907005330 active site 593907005331 motif 3; other site 593907005332 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible...; Region: HGTP_anticodon; cl00266 593907005333 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 593907005334 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 593907005335 putative DNA binding site [nucleotide binding]; other site 593907005336 catalytic residue [active] 593907005337 putative H2TH interface [polypeptide binding]; other site 593907005338 putative catalytic residues [active] 593907005339 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 593907005340 Predicted acetyltransferase [General function prediction only]; Region: COG3393 593907005341 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 593907005342 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 593907005343 Domain of unknown function (DU1801); Region: DUF1801; cl01838 593907005344 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 593907005345 active site 593907005346 zinc metallopeptidase RseP; Provisional; Region: PRK10779 593907005347 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 593907005348 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 593907005349 putative substrate binding region [chemical binding]; other site 593907005350 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 593907005351 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 593907005352 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 593907005353 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 593907005354 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 593907005355 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 593907005356 DivIVA domain; Region: DivI1A_domain; TIGR03544 593907005357 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 593907005358 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 593907005359 FeS/SAM binding site; other site 593907005360 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 593907005361 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 593907005362 hinge region; other site 593907005363 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 593907005364 putative nucleotide binding site [chemical binding]; other site 593907005365 uridine monophosphate binding site [chemical binding]; other site 593907005366 homohexameric interface [polypeptide binding]; other site 593907005367 elongation factor Ts; Provisional; Region: tsf; PRK09377 593907005368 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 593907005369 Elongation factor TS; Region: EF_TS; pfam00889 593907005370 Elongation factor TS; Region: EF_TS; pfam00889 593907005371 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 593907005372 rRNA interaction site [nucleotide binding]; other site 593907005373 S8 interaction site; other site 593907005374 putative laminin-1 binding site; other site 593907005375 Peptidase family M23; Region: Peptidase_M23; pfam01551 593907005376 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 593907005377 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 593907005378 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 593907005379 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 593907005380 DNA binding residues [nucleotide binding] 593907005381 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 593907005382 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 593907005383 DNA binding site [nucleotide binding] 593907005384 Int/Topo IB signature motif; other site 593907005385 active site 593907005386 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 593907005387 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 593907005388 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907005389 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 593907005390 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 593907005391 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 593907005392 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 593907005393 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 593907005394 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 593907005395 Catalytic site [active] 593907005396 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 593907005397 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 593907005398 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 593907005399 RimM N-terminal domain; Region: RimM; pfam01782 593907005400 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 593907005401 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 593907005402 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 593907005403 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 593907005404 active site 593907005405 signal recognition particle protein; Provisional; Region: PRK10867 593907005406 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 593907005407 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 593907005408 P loop; other site 593907005409 GTP binding site [chemical binding]; other site 593907005410 Signal peptide binding domain; Region: SRP_SPB; pfam02978 593907005411 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 593907005412 PII uridylyl-transferase; Provisional; Region: PRK03381 593907005413 metal binding triad; other site 593907005414 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 593907005415 Nitrogen regulatory protein P-II; Region: P-II; cl00412 593907005416 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 593907005417 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 593907005418 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 593907005419 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 593907005420 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 593907005421 Walker A/P-loop; other site 593907005422 ATP binding site [chemical binding]; other site 593907005423 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 593907005424 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 593907005425 ABC transporter signature motif; other site 593907005426 Walker B; other site 593907005427 D-loop; other site 593907005428 H-loop/switch region; other site 593907005429 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 593907005430 active site 593907005431 multimer interface [polypeptide binding]; other site 593907005432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 593907005433 Major Facilitator Superfamily; Region: MFS_1; pfam07690 593907005434 putative substrate translocation pore; other site 593907005435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 593907005436 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 593907005437 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cl00025 593907005438 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 593907005439 dimerization domain swap beta strand [polypeptide binding]; other site 593907005440 regulatory protein interface [polypeptide binding]; other site 593907005441 active site 593907005442 regulatory phosphorylation site [posttranslational modification]; other site 593907005443 DAK2 domain; Region: Dak2; cl03685 593907005444 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 593907005445 Dak1 domain; Region: Dak1; pfam02733 593907005446 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 593907005447 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 593907005448 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 593907005449 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 593907005450 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 593907005451 HIGH motif; other site 593907005452 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 593907005453 active site 593907005454 KMSKS motif; other site 593907005455 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 593907005456 tRNA binding surface [nucleotide binding]; other site 593907005457 anticodon binding site; other site 593907005458 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 593907005459 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 593907005460 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 593907005461 motif II; other site 593907005462 Phosphotransferase enzyme family; Region: APH; pfam01636 593907005463 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 593907005464 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 593907005465 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 593907005466 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 593907005467 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 593907005468 DNA binding residues [nucleotide binding] 593907005469 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 593907005470 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 593907005471 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 593907005472 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907005473 Walker A/P-loop; other site 593907005474 ATP binding site [chemical binding]; other site 593907005475 Q-loop/lid; other site 593907005476 ABC transporter signature motif; other site 593907005477 Walker B; other site 593907005478 D-loop; other site 593907005479 H-loop/switch region; other site 593907005480 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 593907005481 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 593907005482 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907005483 Walker A/P-loop; other site 593907005484 ATP binding site [chemical binding]; other site 593907005485 Q-loop/lid; other site 593907005486 ABC transporter signature motif; other site 593907005487 Walker B; other site 593907005488 D-loop; other site 593907005489 H-loop/switch region; other site 593907005490 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 593907005491 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907005492 NAD(P) binding site [chemical binding]; other site 593907005493 active site 593907005494 hypothetical protein; Provisional; Region: PRK06062 593907005495 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 593907005496 inhibitor-cofactor binding pocket; inhibition site 593907005497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907005498 catalytic residue [active] 593907005499 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907005500 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 593907005501 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 593907005502 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 593907005503 Walker A/P-loop; other site 593907005504 ATP binding site [chemical binding]; other site 593907005505 Q-loop/lid; other site 593907005506 ABC transporter signature motif; other site 593907005507 Walker B; other site 593907005508 D-loop; other site 593907005509 H-loop/switch region; other site 593907005510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 593907005511 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 593907005512 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 593907005513 phenylhydantoinase; Validated; Region: PRK08323 593907005514 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like...; Region: D-HYD; cd01314 593907005515 tetramer interface [polypeptide binding]; other site 593907005516 active site 593907005517 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 593907005518 N-carbamolyputrescine amidase; Region: PLN02747 593907005519 active site 593907005520 catalytic triad [active] 593907005521 dimer interface [polypeptide binding]; other site 593907005522 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 593907005523 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 593907005524 DNA-binding site [nucleotide binding]; DNA binding site 593907005525 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 593907005526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907005527 homodimer interface [polypeptide binding]; other site 593907005528 catalytic residue [active] 593907005529 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 593907005530 intersubunit interface [polypeptide binding]; other site 593907005531 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 593907005532 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 593907005533 putative PBP binding regions; other site 593907005534 ABC-ATPase subunit interface; other site 593907005535 proposed F420-0 ABC transporter, ATP-binding protein; Region: F420-0_ABC_ATP; TIGR03873 593907005536 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 593907005537 Walker A/P-loop; other site 593907005538 ATP binding site [chemical binding]; other site 593907005539 Q-loop/lid; other site 593907005540 ABC transporter signature motif; other site 593907005541 Walker B; other site 593907005542 D-loop; other site 593907005543 H-loop/switch region; other site 593907005544 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425 593907005545 phosphate binding site [ion binding]; other site 593907005546 dimer interface [polypeptide binding]; other site 593907005547 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 593907005548 uncharacterized HhH-GPD family protein; Region: TIGR03252 593907005549 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 593907005550 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 593907005551 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 593907005552 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 593907005553 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 593907005554 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 593907005555 CGNR zinc finger; Region: zf-CGNR; pfam11706 593907005556 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 593907005557 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 593907005558 active site 593907005559 HIGH motif; other site 593907005560 nucleotide binding site [chemical binding]; other site 593907005561 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 593907005562 active site 593907005563 KMSKS motif; other site 593907005564 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 593907005565 tRNA binding surface [nucleotide binding]; other site 593907005566 anticodon binding site; other site 593907005567 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 593907005568 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 593907005569 PilZ domain; Region: PilZ; cl01260 593907005570 Chorismate mutase type II; Region: CM_2; cl00693 593907005571 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 593907005572 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 593907005573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 593907005574 Walker A motif; other site 593907005575 ATP binding site [chemical binding]; other site 593907005576 Walker B motif; other site 593907005577 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 593907005578 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 593907005579 oligomer interface [polypeptide binding]; other site 593907005580 active site residues [active] 593907005581 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 593907005582 oligomer interface [polypeptide binding]; other site 593907005583 active site residues [active] 593907005584 trigger factor; Provisional; Region: tig; PRK01490 593907005585 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 593907005586 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 593907005587 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 593907005588 active site 593907005589 TDP-binding site; other site 593907005590 acceptor substrate-binding pocket; other site 593907005591 homodimer interface [polypeptide binding]; other site 593907005592 putative transposase OrfB; Reviewed; Region: PHA02517 593907005593 Integrase core domain; Region: rve; cl01316 593907005594 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 593907005595 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 593907005596 active site 593907005597 NTP binding site [chemical binding]; other site 593907005598 metal binding triad [ion binding]; metal-binding site 593907005599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907005600 ATP binding site [chemical binding]; other site 593907005601 substrate interface [chemical binding]; other site 593907005602 Predicted ATPase [General function prediction only]; Region: COG3899 593907005603 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 593907005604 dimerization interface [polypeptide binding]; other site 593907005605 DNA binding residues [nucleotide binding] 593907005606 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 593907005607 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 593907005608 active site 593907005609 catalytic triad [active] 593907005610 oxyanion hole [active] 593907005611 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 593907005612 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 593907005613 active site 593907005614 DNA binding site [nucleotide binding] 593907005615 catalytic site [active] 593907005616 cysteine synthases; Region: cysKM; TIGR01136 593907005617 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 593907005618 dimer interface [polypeptide binding]; other site 593907005619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907005620 catalytic residue [active] 593907005621 serine O-acetyltransferase; Region: cysE; TIGR01172 593907005622 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 593907005623 trimer interface [polypeptide binding]; other site 593907005624 active site 593907005625 substrate binding site [chemical binding]; other site 593907005626 CoA binding site [chemical binding]; other site 593907005627 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 593907005628 nudix motif; other site 593907005629 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 593907005630 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 593907005631 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cl01497 593907005632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907005633 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 593907005634 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 593907005635 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 593907005636 active site 593907005637 Zn binding site [ion binding]; other site 593907005638 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 593907005639 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 593907005640 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 593907005641 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 593907005642 Walker A/P-loop; other site 593907005643 ATP binding site [chemical binding]; other site 593907005644 Q-loop/lid; other site 593907005645 ABC transporter signature motif; other site 593907005646 Walker B; other site 593907005647 D-loop; other site 593907005648 H-loop/switch region; other site 593907005649 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907005650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 593907005651 Domain of unknown function DUF77; Region: DUF77; cl00307 593907005652 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 593907005653 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 593907005654 Zn binding site [ion binding]; other site 593907005655 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 593907005656 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 593907005657 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 593907005658 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 593907005659 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 593907005660 Mechanosensitive ion channel; Region: MS_channel; pfam00924 593907005661 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 593907005662 HPr interaction site; other site 593907005663 glycerol kinase (GK) interaction site [polypeptide binding]; other site 593907005664 active site 593907005665 phosphorylation site [posttranslational modification] 593907005666 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 593907005667 active site turn [active] 593907005668 phosphorylation site [posttranslational modification] 593907005669 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 593907005670 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 593907005671 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 593907005672 apolar tunnel; other site 593907005673 heme binding site [chemical binding]; other site 593907005674 dimerization interface [polypeptide binding]; other site 593907005675 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 593907005676 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 593907005677 active site 593907005678 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 593907005679 catalytic triad [active] 593907005680 dimer interface [polypeptide binding]; other site 593907005681 Transport protein; Region: actII; TIGR00833 593907005682 Transport protein; Region: actII; TIGR00833 593907005683 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 593907005684 DNA binding site [nucleotide binding] 593907005685 Int/Topo IB signature motif; other site 593907005686 active site 593907005687 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 593907005688 putative NAD(P) binding site [chemical binding]; other site 593907005689 putative active site [active] 593907005690 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 593907005691 active site 593907005692 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 593907005693 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907005694 Walker A/P-loop; other site 593907005695 ATP binding site [chemical binding]; other site 593907005696 Q-loop/lid; other site 593907005697 ABC transporter signature motif; other site 593907005698 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 593907005699 ABC transporter; Region: ABC_tran_2; pfam12848 593907005700 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 593907005701 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 593907005702 dimer interface [polypeptide binding]; other site 593907005703 ssDNA binding site [nucleotide binding]; other site 593907005704 tetramer (dimer of dimers) interface [polypeptide binding]; other site 593907005705 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 593907005706 G1 box; other site 593907005707 GTP/Mg2+ binding site [chemical binding]; other site 593907005708 Switch I region; other site 593907005709 G2 box; other site 593907005710 Switch II region; other site 593907005711 G3 box; other site 593907005712 G4 box; other site 593907005713 G5 box; other site 593907005714 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 593907005715 Switch I region; other site 593907005716 G2 box; other site 593907005717 Switch II region; other site 593907005718 G3 box; other site 593907005719 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 593907005720 putative hydrophobic ligand binding site [chemical binding]; other site 593907005721 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 593907005722 putative active site [active] 593907005723 putative substrate binding site [chemical binding]; other site 593907005724 catalytic site [active] 593907005725 dimer interface [polypeptide binding]; other site 593907005726 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 593907005727 oligomerisation interface [polypeptide binding]; other site 593907005728 mobile loop; other site 593907005729 roof hairpin; other site 593907005730 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 593907005731 catalytic triad [active] 593907005732 Domain of unknown function DUF21; Region: DUF21; pfam01595 593907005733 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 593907005734 Domain of unknown function DUF21; Region: DUF21; pfam01595 593907005735 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 593907005736 Transporter associated domain; Region: CorC_HlyC; pfam03471 593907005737 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 593907005738 catalytic residues [active] 593907005739 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 593907005740 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907005741 Walker A/P-loop; other site 593907005742 ATP binding site [chemical binding]; other site 593907005743 Q-loop/lid; other site 593907005744 ABC transporter signature motif; other site 593907005745 Walker B; other site 593907005746 D-loop; other site 593907005747 H-loop/switch region; other site 593907005748 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907005749 Walker A/P-loop; other site 593907005750 ATP binding site [chemical binding]; other site 593907005751 ABC transporter signature motif; other site 593907005752 Walker B; other site 593907005753 D-loop; other site 593907005754 H-loop/switch region; other site 593907005755 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 593907005756 active site 593907005757 dimerization interface [polypeptide binding]; other site 593907005758 ribonuclease PH; Reviewed; Region: rph; PRK00173 593907005759 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 593907005760 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 593907005761 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 593907005762 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 593907005763 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 593907005764 Integrase core domain; Region: rve; cl01316 593907005765 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 593907005766 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 593907005767 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 593907005768 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 593907005769 active site 593907005770 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 593907005771 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 593907005772 ATP binding site [chemical binding]; other site 593907005773 putative Mg++ binding site [ion binding]; other site 593907005774 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 593907005775 ATP-binding site [chemical binding]; other site 593907005776 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 593907005777 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 593907005778 active site 593907005779 trimer interface [polypeptide binding]; other site 593907005780 allosteric site; other site 593907005781 active site lid [active] 593907005782 hexamer (dimer of trimers) interface [polypeptide binding]; other site 593907005783 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 593907005784 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 593907005785 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 593907005786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907005787 dimer interface [polypeptide binding]; other site 593907005788 conserved gate region; other site 593907005789 putative PBP binding loops; other site 593907005790 ABC-ATPase subunit interface; other site 593907005791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907005792 dimer interface [polypeptide binding]; other site 593907005793 conserved gate region; other site 593907005794 putative PBP binding loops; other site 593907005795 ABC-ATPase subunit interface; other site 593907005796 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 593907005797 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907005798 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907005799 putative switch regulator; other site 593907005800 non-specific DNA interactions [nucleotide binding]; other site 593907005801 DNA binding site [nucleotide binding] 593907005802 sequence specific DNA binding site [nucleotide binding]; other site 593907005803 putative cAMP binding site [chemical binding]; other site 593907005804 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 593907005805 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 593907005806 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 593907005807 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 593907005808 active site 593907005809 dimer interface [polypeptide binding]; other site 593907005810 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 593907005811 dimer interface [polypeptide binding]; other site 593907005812 active site 593907005813 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 593907005814 Multicopper oxidase; Region: Cu-oxidase; cl14658 593907005815 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 593907005816 putative DNA binding site [nucleotide binding]; other site 593907005817 dimerization interface [polypeptide binding]; other site 593907005818 Predicted transcriptional regulator [Transcription]; Region: COG2345 593907005819 putative Zn2+ binding site [ion binding]; other site 593907005820 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cl00436 593907005821 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 593907005822 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 593907005823 RNA binding surface [nucleotide binding]; other site 593907005824 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 593907005825 active site 593907005826 catalytic triad [active] 593907005827 oxyanion hole [active] 593907005828 Cellulose binding domain; Region: CBM_2; cl02709 593907005829 YCII-related domain; Region: YCII; cl00999 593907005830 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 593907005831 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 593907005832 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 593907005833 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 593907005834 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 593907005835 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 593907005836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 593907005837 S-adenosylmethionine binding site [chemical binding]; other site 593907005838 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 593907005839 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 593907005840 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 593907005841 UvrD/REP helicase; Region: UvrD-helicase; cl14126 593907005842 UvrD/REP helicase; Region: UvrD-helicase; cl14126 593907005843 UvrD/REP helicase; Region: UvrD-helicase; cl14126 593907005844 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 593907005845 Putative ATPase (DUF699); Region: DUF699; pfam05127 593907005846 UvrD/REP helicase; Region: UvrD-helicase; cl14126 593907005847 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 593907005848 Predicted esterase [General function prediction only]; Region: COG0627 593907005849 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 593907005850 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 593907005851 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 593907005852 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 593907005853 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 593907005854 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 593907005855 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 593907005856 substrate binding [chemical binding]; other site 593907005857 active site 593907005858 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 593907005859 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 593907005860 Ligand binding site [chemical binding]; other site 593907005861 Putative Catalytic site [active] 593907005862 DXD motif; other site 593907005863 GtrA-like protein; Region: GtrA; cl00971 593907005864 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 593907005865 DNA polymerase IV; Validated; Region: PRK03858 593907005866 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 593907005867 active site 593907005868 DNA binding site [nucleotide binding] 593907005869 Domain of unknown function (DUF1994); Region: DUF1994; pfam09352 593907005870 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 593907005871 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 593907005872 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907005873 Walker A/P-loop; other site 593907005874 ATP binding site [chemical binding]; other site 593907005875 ABC transporter signature motif; other site 593907005876 Walker B; other site 593907005877 D-loop; other site 593907005878 H-loop/switch region; other site 593907005879 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 593907005880 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 593907005881 MatE; Region: MatE; pfam01554 593907005882 MatE; Region: MatE; pfam01554 593907005883 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 593907005884 anti sigma factor interaction site; other site 593907005885 regulatory phosphorylation site [posttranslational modification]; other site 593907005886 Domain of unknown function DUF222; Region: DUF222; pfam02720 593907005887 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 593907005888 active site 593907005889 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 593907005890 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 593907005891 ethanolamine permease; Region: 2A0305; TIGR00908 593907005892 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 593907005893 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 593907005894 pyruvate dehydrogenase; Provisional; Region: PRK09124 593907005895 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 593907005896 PYR/PP interface [polypeptide binding]; other site 593907005897 tetramer interface [polypeptide binding]; other site 593907005898 dimer interface [polypeptide binding]; other site 593907005899 TPP binding site [chemical binding]; other site 593907005900 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 593907005901 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014 593907005902 TPP-binding site [chemical binding]; other site 593907005903 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 593907005904 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 593907005905 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 593907005906 trehalose synthase; Region: treS_nterm; TIGR02456 593907005907 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 593907005908 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl14635 593907005909 Catalytic domain of Protein Kinases; Region: PKc; cd00180 593907005910 active site 593907005911 ATP binding site [chemical binding]; other site 593907005912 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 593907005913 substrate binding site [chemical binding]; other site 593907005914 activation loop (A-loop); other site 593907005915 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 593907005916 metal binding site [ion binding]; metal-binding site 593907005917 active site 593907005918 I-site; other site 593907005919 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 593907005920 DinB superfamily; Region: DinB_2; cl00986 593907005921 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 593907005922 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 593907005923 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 593907005924 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 593907005925 active site 593907005926 DNA binding site [nucleotide binding] 593907005927 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 593907005928 DNA binding site [nucleotide binding] 593907005929 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 593907005930 SmpB-tmRNA interface; other site 593907005931 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 593907005932 Peptidase family M23; Region: Peptidase_M23; pfam01551 593907005933 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 593907005934 FtsX-like permease family; Region: FtsX; pfam02687 593907005935 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 593907005936 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907005937 Walker A/P-loop; other site 593907005938 ATP binding site [chemical binding]; other site 593907005939 Q-loop/lid; other site 593907005940 ABC transporter signature motif; other site 593907005941 Walker B; other site 593907005942 D-loop; other site 593907005943 H-loop/switch region; other site 593907005944 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 593907005945 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 593907005946 Walker A/P-loop; other site 593907005947 ATP binding site [chemical binding]; other site 593907005948 Q-loop/lid; other site 593907005949 ABC transporter signature motif; other site 593907005950 Walker B; other site 593907005951 D-loop; other site 593907005952 H-loop/switch region; other site 593907005953 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907005954 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 593907005955 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 593907005956 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 593907005957 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 593907005958 TM-ABC transporter signature motif; other site 593907005959 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 593907005960 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 593907005961 Walker A/P-loop; other site 593907005962 ATP binding site [chemical binding]; other site 593907005963 Q-loop/lid; other site 593907005964 ABC transporter signature motif; other site 593907005965 Walker B; other site 593907005966 D-loop; other site 593907005967 H-loop/switch region; other site 593907005968 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 593907005969 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 593907005970 putative ligand binding site [chemical binding]; other site 593907005971 Transcriptional regulators [Transcription]; Region: PurR; COG1609 593907005972 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 593907005973 DNA binding site [nucleotide binding] 593907005974 domain linker motif; other site 593907005975 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 593907005976 dimerization interface [polypeptide binding]; other site 593907005977 ligand binding site [chemical binding]; other site 593907005978 peptide chain release factor 2; Validated; Region: prfB; PRK00578 593907005979 RF-1 domain; Region: RF-1; cl02875 593907005980 RF-1 domain; Region: RF-1; cl02875 593907005981 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 593907005982 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 593907005983 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 593907005984 ATP binding site [chemical binding]; other site 593907005985 Walker A motif; other site 593907005986 hexamer interface [polypeptide binding]; other site 593907005987 Walker B motif; other site 593907005988 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 593907005989 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 593907005990 active site 593907005991 catalytic residues [active] 593907005992 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 593907005993 Domain of unknown function DUF21; Region: DUF21; pfam01595 593907005994 FOG: CBS domain [General function prediction only]; Region: COG0517 593907005995 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 593907005996 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 593907005997 Domain of unknown function DUF21; Region: DUF21; pfam01595 593907005998 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 593907005999 Transporter associated domain; Region: CorC_HlyC; pfam03471 593907006000 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 593907006001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 593907006002 active site 593907006003 phosphorylation site [posttranslational modification] 593907006004 intermolecular recognition site; other site 593907006005 dimerization interface [polypeptide binding]; other site 593907006006 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 593907006007 DNA binding site [nucleotide binding] 593907006008 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 593907006009 dimerization interface [polypeptide binding]; other site 593907006010 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 593907006011 dimer interface [polypeptide binding]; other site 593907006012 phosphorylation site [posttranslational modification] 593907006013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 593907006014 ATP binding site [chemical binding]; other site 593907006015 Mg2+ binding site [ion binding]; other site 593907006016 G-X-G motif; other site 593907006017 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 593907006018 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 593907006019 FeS/SAM binding site; other site 593907006020 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 593907006021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907006022 Walker A/P-loop; other site 593907006023 ATP binding site [chemical binding]; other site 593907006024 Q-loop/lid; other site 593907006025 ABC transporter signature motif; other site 593907006026 Walker B; other site 593907006027 D-loop; other site 593907006028 H-loop/switch region; other site 593907006029 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 593907006030 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 593907006031 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 593907006032 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016 593907006033 TPP-binding site [chemical binding]; other site 593907006034 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 593907006035 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 593907006036 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 593907006037 conserved cys residue [active] 593907006038 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 593907006039 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 593907006040 active site 593907006041 catalytic triad [active] 593907006042 oxyanion hole [active] 593907006043 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907006044 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 593907006045 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 593907006046 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 593907006047 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907006048 Walker A motif; other site 593907006049 ATP binding site [chemical binding]; other site 593907006050 Walker B motif; other site 593907006051 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl11829 593907006052 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 593907006053 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 593907006054 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 593907006055 DNA binding residues [nucleotide binding] 593907006056 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 593907006057 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 593907006058 hinge; other site 593907006059 active site 593907006060 Predicted GTPases [General function prediction only]; Region: COG1162 593907006061 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 593907006062 GTP/Mg2+ binding site [chemical binding]; other site 593907006063 G4 box; other site 593907006064 G5 box; other site 593907006065 G1 box; other site 593907006066 Switch I region; other site 593907006067 G2 box; other site 593907006068 G3 box; other site 593907006069 Switch II region; other site 593907006070 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 593907006071 active site 593907006072 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 593907006073 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 593907006074 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 593907006075 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 593907006076 HIGH motif; other site 593907006077 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 593907006078 active site 593907006079 KMSKS motif; other site 593907006080 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 593907006081 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 593907006082 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 593907006083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 593907006084 S-adenosylmethionine binding site [chemical binding]; other site 593907006085 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 593907006086 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 593907006087 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 593907006088 active site 593907006089 nucleotide binding site [chemical binding]; other site 593907006090 HIGH motif; other site 593907006091 KMSKS motif; other site 593907006092 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; cl01238 593907006093 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 593907006094 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 593907006095 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 593907006096 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 593907006097 Walker A/P-loop; other site 593907006098 ATP binding site [chemical binding]; other site 593907006099 Q-loop/lid; other site 593907006100 ABC transporter signature motif; other site 593907006101 Walker B; other site 593907006102 D-loop; other site 593907006103 H-loop/switch region; other site 593907006104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 593907006105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 593907006106 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907006107 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907006108 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 593907006109 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 593907006110 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 593907006111 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907006112 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907006113 dimerization interface [polypeptide binding]; other site 593907006114 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 593907006115 gating phenylalanine in ion channel; other site 593907006116 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 593907006117 catalytic triad [active] 593907006118 ski2-like helicase; Provisional; Region: PRK02362 593907006119 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 593907006120 ATP binding site [chemical binding]; other site 593907006121 putative Mg++ binding site [ion binding]; other site 593907006122 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 593907006123 nucleotide binding region [chemical binding]; other site 593907006124 ATP-binding site [chemical binding]; other site 593907006125 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 593907006126 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 593907006127 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002 593907006128 putative deacylase active site [active] 593907006129 hypothetical protein; Provisional; Region: PRK11770 593907006130 Domain of unknown function (DUF307); Region: DUF307; pfam03733 593907006131 Domain of unknown function (DUF307); Region: DUF307; pfam03733 593907006132 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 593907006133 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 593907006134 catalytic residue [active] 593907006135 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 593907006136 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 593907006137 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 593907006138 active site 593907006139 catalytic residues [active] 593907006140 metal binding site [ion binding]; metal-binding site 593907006141 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 593907006142 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 593907006143 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 593907006144 homodimer interface [polypeptide binding]; other site 593907006145 substrate-cofactor binding pocket; other site 593907006146 catalytic residue [active] 593907006147 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 593907006148 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation...; Region: ASCH; cl01020 593907006149 ketol-acid reductoisomerase; Provisional; Region: PRK05479 593907006150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907006151 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 593907006152 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 593907006153 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 593907006154 putative valine binding site [chemical binding]; other site 593907006155 dimer interface [polypeptide binding]; other site 593907006156 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 593907006157 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 593907006158 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 593907006159 PYR/PP interface [polypeptide binding]; other site 593907006160 dimer interface [polypeptide binding]; other site 593907006161 TPP binding site [chemical binding]; other site 593907006162 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 593907006163 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 593907006164 TPP-binding site [chemical binding]; other site 593907006165 dimer interface [polypeptide binding]; other site 593907006166 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 593907006167 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 593907006168 Walker A/P-loop; other site 593907006169 ATP binding site [chemical binding]; other site 593907006170 Q-loop/lid; other site 593907006171 ABC transporter signature motif; other site 593907006172 Walker B; other site 593907006173 D-loop; other site 593907006174 H-loop/switch region; other site 593907006175 ABC-2 type transporter; Region: ABC2_membrane; cl11417 593907006176 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 593907006177 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907006178 Walker A/P-loop; other site 593907006179 ATP binding site [chemical binding]; other site 593907006180 Q-loop/lid; other site 593907006181 ABC transporter signature motif; other site 593907006182 Walker B; other site 593907006183 D-loop; other site 593907006184 H-loop/switch region; other site 593907006185 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 593907006186 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 593907006187 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 593907006188 Dehydratase family; Region: ILVD_EDD; cl00340 593907006189 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 593907006190 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 593907006191 metal binding site [ion binding]; metal-binding site 593907006192 active site 593907006193 I-site; other site 593907006194 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 593907006195 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 593907006196 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 593907006197 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 593907006198 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 593907006199 Dehydratase family; Region: ILVD_EDD; cl00340 593907006200 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 593907006201 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 593907006202 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 593907006203 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 593907006204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907006205 dimer interface [polypeptide binding]; other site 593907006206 conserved gate region; other site 593907006207 ABC-ATPase subunit interface; other site 593907006208 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 593907006209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907006210 dimer interface [polypeptide binding]; other site 593907006211 conserved gate region; other site 593907006212 putative PBP binding loops; other site 593907006213 ABC-ATPase subunit interface; other site 593907006214 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 593907006215 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907006216 Transcriptional regulators [Transcription]; Region: PurR; COG1609 593907006217 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 593907006218 DNA binding site [nucleotide binding] 593907006219 domain linker motif; other site 593907006220 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 593907006221 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 593907006222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 593907006223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 593907006224 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 593907006225 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907006226 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 593907006227 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 593907006228 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 593907006229 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 593907006230 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 593907006231 putative ligand binding site [chemical binding]; other site 593907006232 Immunoglobulin domain; Region: Ig; cl11960 593907006233 Immunoglobulin domain; Region: Ig; cl11960 593907006234 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 593907006235 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 593907006236 GatB domain; Region: GatB_Yqey; cl11497 593907006237 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 593907006238 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 593907006239 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 593907006240 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 593907006241 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907006242 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 593907006243 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 593907006244 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907006245 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907006246 Ligase N family; Region: LIGANc; smart00532 593907006247 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 593907006248 nucleotide binding pocket [chemical binding]; other site 593907006249 K-X-D-G motif; other site 593907006250 catalytic site [active] 593907006251 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 593907006252 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 593907006253 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 593907006254 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 593907006255 Dimer interface [polypeptide binding]; other site 593907006256 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine...; Region: URO-D_CIMS_like; cl00464 593907006257 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 593907006258 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 593907006259 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 593907006260 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 593907006261 catalytic residue [active] 593907006262 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 593907006263 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 593907006264 active site 593907006265 ATP binding site [chemical binding]; other site 593907006266 6-phosphofructokinase; Provisional; Region: PRK03202 593907006267 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 593907006268 active site 593907006269 ADP/pyrophosphate binding site [chemical binding]; other site 593907006270 dimerization interface [polypeptide binding]; other site 593907006271 allosteric effector site; other site 593907006272 fructose-1,6-bisphosphate binding site; other site 593907006273 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 593907006274 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 593907006275 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 593907006276 Ligand binding site [chemical binding]; other site 593907006277 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 593907006278 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 593907006279 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 593907006280 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 593907006281 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 593907006282 FAD binding domain; Region: FAD_binding_2; pfam00890 593907006283 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 593907006284 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 593907006285 trehalose synthase; Region: treS_nterm; TIGR02456 593907006286 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 593907006287 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 593907006288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907006289 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 593907006290 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 593907006291 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907006292 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 593907006293 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907006294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907006295 dimer interface [polypeptide binding]; other site 593907006296 conserved gate region; other site 593907006297 ABC-ATPase subunit interface; other site 593907006298 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 593907006299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907006300 dimer interface [polypeptide binding]; other site 593907006301 conserved gate region; other site 593907006302 putative PBP binding loops; other site 593907006303 ABC-ATPase subunit interface; other site 593907006304 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 593907006305 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 593907006306 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 593907006307 ligand binding site [chemical binding]; other site 593907006308 dimerization interface [polypeptide binding]; other site 593907006309 glycogen branching enzyme; Provisional; Region: PRK05402 593907006310 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 593907006311 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 593907006312 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 593907006313 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 593907006314 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 593907006315 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 593907006316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907006317 dimer interface [polypeptide binding]; other site 593907006318 conserved gate region; other site 593907006319 putative PBP binding loops; other site 593907006320 ABC-ATPase subunit interface; other site 593907006321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907006322 dimer interface [polypeptide binding]; other site 593907006323 conserved gate region; other site 593907006324 putative PBP binding loops; other site 593907006325 ABC-ATPase subunit interface; other site 593907006326 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 593907006327 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907006328 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 593907006329 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 593907006330 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 593907006331 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 593907006332 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 593907006333 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 593907006334 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 593907006335 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 593907006336 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 593907006337 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 593907006338 active site 593907006339 motif I; other site 593907006340 motif II; other site 593907006341 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 593907006342 putative alpha-glucosidase; Provisional; Region: PRK10658 593907006343 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 593907006344 active site 593907006345 homotrimer interface [polypeptide binding]; other site 593907006346 catalytic site [active] 593907006347 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 593907006348 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 593907006349 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 593907006350 Transcriptional regulators [Transcription]; Region: PurR; COG1609 593907006351 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 593907006352 DNA binding site [nucleotide binding] 593907006353 domain linker motif; other site 593907006354 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 593907006355 dimerization interface [polypeptide binding]; other site 593907006356 ligand binding site [chemical binding]; other site 593907006357 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 593907006358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907006359 dimer interface [polypeptide binding]; other site 593907006360 conserved gate region; other site 593907006361 putative PBP binding loops; other site 593907006362 ABC-ATPase subunit interface; other site 593907006363 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 593907006364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907006365 dimer interface [polypeptide binding]; other site 593907006366 conserved gate region; other site 593907006367 ABC-ATPase subunit interface; other site 593907006368 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 593907006369 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 593907006370 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 593907006371 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 593907006372 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 593907006373 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 593907006374 active site 593907006375 Protein of unknown function DUF91; Region: DUF91; cl00709 593907006376 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 593907006377 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 593907006378 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 593907006379 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 593907006380 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 593907006381 alpha subunit interaction interface [polypeptide binding]; other site 593907006382 Walker A motif; other site 593907006383 ATP binding site [chemical binding]; other site 593907006384 Walker B motif; other site 593907006385 inhibitor binding site; inhibition site 593907006386 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 593907006387 ATP synthase; Region: ATP-synt; cl00365 593907006388 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 593907006389 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 593907006390 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 593907006391 beta subunit interaction interface [polypeptide binding]; other site 593907006392 Walker A motif; other site 593907006393 ATP binding site [chemical binding]; other site 593907006394 Walker B motif; other site 593907006395 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 593907006396 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 593907006397 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 593907006398 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 593907006399 ATP synthase subunit C; Region: ATP-synt_C; cl00466 593907006400 ATP synthase A chain; Region: ATP-synt_A; cl00413 593907006401 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 593907006402 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 593907006403 Mg++ binding site [ion binding]; other site 593907006404 putative catalytic motif [active] 593907006405 substrate binding site [chemical binding]; other site 593907006406 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 593907006407 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 593907006408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 593907006409 S-adenosylmethionine binding site [chemical binding]; other site 593907006410 peptide chain release factor 1; Validated; Region: prfA; PRK00591 593907006411 RF-1 domain; Region: RF-1; cl02875 593907006412 RF-1 domain; Region: RF-1; cl02875 593907006413 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 593907006414 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 593907006415 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 593907006416 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 593907006417 transcription termination factor Rho; Provisional; Region: PRK12608 593907006418 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 593907006419 RNA binding site [nucleotide binding]; other site 593907006420 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 593907006421 multimer interface [polypeptide binding]; other site 593907006422 Walker A motif; other site 593907006423 ATP binding site [chemical binding]; other site 593907006424 Walker B motif; other site 593907006425 homoserine kinase; Provisional; Region: PRK01212 593907006426 threonine synthase; Reviewed; Region: PRK06721 593907006427 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 593907006428 homodimer interface [polypeptide binding]; other site 593907006429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907006430 catalytic residue [active] 593907006431 homoserine dehydrogenase; Provisional; Region: PRK06349 593907006432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907006433 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 593907006434 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 593907006435 diaminopimelate decarboxylase; Region: lysA; TIGR01048 593907006436 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 593907006437 active site 593907006438 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 593907006439 substrate binding site [chemical binding]; other site 593907006440 catalytic residues [active] 593907006441 dimer interface [polypeptide binding]; other site 593907006442 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 593907006443 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 593907006444 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 593907006445 active site 593907006446 HIGH motif; other site 593907006447 KMSK motif region; other site 593907006448 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 593907006449 anticodon binding site; other site 593907006450 tRNA binding surface [nucleotide binding]; other site 593907006451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 593907006452 cyanate transporter; Region: CynX; TIGR00896 593907006453 putative substrate translocation pore; other site 593907006454 Transcriptional regulators [Transcription]; Region: FadR; COG2186 593907006455 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 593907006456 DNA-binding site [nucleotide binding]; DNA binding site 593907006457 FCD domain; Region: FCD; cl11656 593907006458 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 593907006459 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 593907006460 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 593907006461 putative catalytic cysteine [active] 593907006462 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 593907006463 putative active site [active] 593907006464 metal binding site [ion binding]; metal-binding site 593907006465 hypothetical protein; Provisional; Region: PRK08912 593907006466 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 593907006467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907006468 homodimer interface [polypeptide binding]; other site 593907006469 catalytic residue [active] 593907006470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 593907006471 putative substrate translocation pore; other site 593907006472 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 593907006473 cyclase homology domain; Region: CHD; cd07302 593907006474 nucleotidyl binding site; other site 593907006475 metal binding site [ion binding]; metal-binding site 593907006476 dimer interface [polypeptide binding]; other site 593907006477 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 593907006478 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 593907006479 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 593907006480 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 593907006481 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 593907006482 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 593907006483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 593907006484 Vitamin K epoxide reductase family; Region: VKOR; cl01729 593907006485 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 593907006486 dimer interface [polypeptide binding]; other site 593907006487 active site 593907006488 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 593907006489 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 593907006490 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 593907006491 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 593907006492 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 593907006493 carboxyltransferase (CT) interaction site; other site 593907006494 biotinylation site [posttranslational modification]; other site 593907006495 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 593907006496 nudix motif; other site 593907006497 Iron permease FTR1 family; Region: FTR1; cl00475 593907006498 Imelysin; Region: Peptidase_M75; cl09159 593907006499 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 593907006500 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 593907006501 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 593907006502 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 593907006503 putative catalytic site [active] 593907006504 putative metal binding site [ion binding]; other site 593907006505 putative phosphate binding site [ion binding]; other site 593907006506 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 593907006507 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 593907006508 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 593907006509 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 593907006510 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 593907006511 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 593907006512 active site 593907006513 substrate binding site [chemical binding]; other site 593907006514 metal binding site [ion binding]; metal-binding site 593907006515 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 593907006516 intersubunit interface [polypeptide binding]; other site 593907006517 active site 593907006518 catalytic residue [active] 593907006519 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 593907006520 active site 593907006521 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 593907006522 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 593907006523 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 593907006524 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 593907006525 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 593907006526 active site 593907006527 catalytic motif [active] 593907006528 Zn binding site [ion binding]; other site 593907006529 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 593907006530 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 593907006531 TM-ABC transporter signature motif; other site 593907006532 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 593907006533 TM-ABC transporter signature motif; other site 593907006534 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 593907006535 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 593907006536 Walker A/P-loop; other site 593907006537 ATP binding site [chemical binding]; other site 593907006538 Q-loop/lid; other site 593907006539 ABC transporter signature motif; other site 593907006540 Walker B; other site 593907006541 D-loop; other site 593907006542 H-loop/switch region; other site 593907006543 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 593907006544 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 593907006545 ligand binding site [chemical binding]; other site 593907006546 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 593907006547 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 593907006548 metal binding site [ion binding]; metal-binding site 593907006549 putative dimer interface [polypeptide binding]; other site 593907006550 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 593907006551 active site 593907006552 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 593907006553 putative Iron-sulfur protein interface [polypeptide binding]; other site 593907006554 putative proximal heme binding site [chemical binding]; other site 593907006555 putative SdhD-like interface [polypeptide binding]; other site 593907006556 putative distal heme binding site [chemical binding]; other site 593907006557 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 593907006558 putative Iron-sulfur protein interface [polypeptide binding]; other site 593907006559 putative proximal heme binding site [chemical binding]; other site 593907006560 putative SdhC-like subunit interface [polypeptide binding]; other site 593907006561 putative distal heme binding site [chemical binding]; other site 593907006562 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 593907006563 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 593907006564 domain; Region: Succ_DH_flav_C; pfam02910 593907006565 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 593907006566 Phosphotransferase enzyme family; Region: APH; pfam01636 593907006567 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 593907006568 active site 593907006569 ATP binding site [chemical binding]; other site 593907006570 substrate binding site [chemical binding]; other site 593907006571 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 593907006572 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 593907006573 hypothetical protein; Provisional; Region: PRK13679 593907006574 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 593907006575 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 593907006576 active site 593907006577 HIGH motif; other site 593907006578 dimer interface [polypeptide binding]; other site 593907006579 KMSKS motif; other site 593907006580 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 593907006581 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 593907006582 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 593907006583 RNA polymerase sigma factor; Provisional; Region: PRK12522 593907006584 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 593907006585 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 593907006586 DNA binding residues [nucleotide binding] 593907006587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 593907006588 S-adenosylmethionine binding site [chemical binding]; other site 593907006589 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 593907006590 interface (dimer of trimers) [polypeptide binding]; other site 593907006591 Substrate-binding/catalytic site; other site 593907006592 Zn-binding sites [ion binding]; other site 593907006593 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 593907006594 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 593907006595 dihydropteroate synthase; Region: DHPS; TIGR01496 593907006596 substrate binding pocket [chemical binding]; other site 593907006597 dimer interface [polypeptide binding]; other site 593907006598 inhibitor binding site; inhibition site 593907006599 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 593907006600 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 593907006601 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 593907006602 metal binding site [ion binding]; metal-binding site 593907006603 putative dimer interface [polypeptide binding]; other site 593907006604 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 593907006605 ResB-like family; Region: ResB; pfam05140 593907006606 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 593907006607 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 593907006608 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 593907006609 catalytic residues [active] 593907006610 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 593907006611 catalytic core [active] 593907006612 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 593907006613 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907006614 YceI-like domain; Region: YceI; cl01001 593907006615 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 593907006616 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 593907006617 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 593907006618 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 593907006619 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907006620 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 593907006621 substrate binding site [chemical binding]; other site 593907006622 active site 593907006623 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 593907006624 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 593907006625 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 593907006626 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 593907006627 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 593907006628 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907006629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 593907006630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907006631 putative PBP binding loops; other site 593907006632 dimer interface [polypeptide binding]; other site 593907006633 ABC-ATPase subunit interface; other site 593907006634 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 593907006635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907006636 dimer interface [polypeptide binding]; other site 593907006637 conserved gate region; other site 593907006638 putative PBP binding loops; other site 593907006639 ABC-ATPase subunit interface; other site 593907006640 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 593907006641 substrate binding site [chemical binding]; other site 593907006642 active site 593907006643 Transcriptional regulators [Transcription]; Region: PurR; COG1609 593907006644 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 593907006645 DNA binding site [nucleotide binding] 593907006646 domain linker motif; other site 593907006647 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 593907006648 dimerization interface [polypeptide binding]; other site 593907006649 ligand binding site [chemical binding]; other site 593907006650 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; cl06815 593907006651 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 593907006652 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 593907006653 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 593907006654 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 593907006655 Cation transport protein; Region: TrkH; cl10514 593907006656 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 593907006657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907006658 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 593907006659 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 593907006660 Transcriptional regulators [Transcription]; Region: MarR; COG1846 593907006661 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907006662 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 593907006663 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 593907006664 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 593907006665 catalytic site [active] 593907006666 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 593907006667 active site 593907006668 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 593907006669 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 593907006670 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 593907006671 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 593907006672 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 593907006673 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 593907006674 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 593907006675 TM-ABC transporter signature motif; other site 593907006676 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 593907006677 TM-ABC transporter signature motif; other site 593907006678 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 593907006679 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 593907006680 Walker A/P-loop; other site 593907006681 ATP binding site [chemical binding]; other site 593907006682 Q-loop/lid; other site 593907006683 ABC transporter signature motif; other site 593907006684 Walker B; other site 593907006685 D-loop; other site 593907006686 H-loop/switch region; other site 593907006687 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 593907006688 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 593907006689 L-arabinose isomerase; Provisional; Region: PRK02929 593907006690 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of...; Region: L-fuc_L-ara-isomerases; cl00947 593907006691 hexamer (dimer of trimers) interface [polypeptide binding]; other site 593907006692 trimer interface [polypeptide binding]; other site 593907006693 substrate binding site [chemical binding]; other site 593907006694 Mn binding site [ion binding]; other site 593907006695 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 593907006696 intersubunit interface [polypeptide binding]; other site 593907006697 active site 593907006698 Zn2+ binding site [ion binding]; other site 593907006699 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 593907006700 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 593907006701 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 593907006702 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; cl06815 593907006703 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 593907006704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907006705 dimer interface [polypeptide binding]; other site 593907006706 conserved gate region; other site 593907006707 putative PBP binding loops; other site 593907006708 ABC-ATPase subunit interface; other site 593907006709 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 593907006710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907006711 ABC-ATPase subunit interface; other site 593907006712 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907006713 Transcriptional regulators [Transcription]; Region: PurR; COG1609 593907006714 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 593907006715 DNA binding site [nucleotide binding] 593907006716 domain linker motif; other site 593907006717 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 593907006718 dimerization interface [polypeptide binding]; other site 593907006719 ligand binding site [chemical binding]; other site 593907006720 Domain of unknown function (DUF74); Region: DUF74; cl00426 593907006721 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 593907006722 substrate binding site [chemical binding]; other site 593907006723 active site 593907006724 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 593907006725 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 593907006726 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 593907006727 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 593907006728 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 593907006729 Transcriptional regulators [Transcription]; Region: PurR; COG1609 593907006730 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 593907006731 DNA binding site [nucleotide binding] 593907006732 domain linker motif; other site 593907006733 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 593907006734 ligand binding site [chemical binding]; other site 593907006735 dimerization interface (open form) [polypeptide binding]; other site 593907006736 dimerization interface (closed form) [polypeptide binding]; other site 593907006737 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 593907006738 active site 593907006739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907006740 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 593907006741 HlyD family secretion protein; Region: HlyD_2; pfam12700 593907006742 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 593907006743 FtsX-like permease family; Region: FtsX; pfam02687 593907006744 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 593907006745 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 593907006746 Walker A/P-loop; other site 593907006747 ATP binding site [chemical binding]; other site 593907006748 Q-loop/lid; other site 593907006749 ABC transporter signature motif; other site 593907006750 Walker B; other site 593907006751 D-loop; other site 593907006752 H-loop/switch region; other site 593907006753 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 593907006754 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 593907006755 DNA photolyase; Region: DNA_photolyase; pfam00875 593907006756 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 593907006757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 593907006758 S-adenosylmethionine binding site [chemical binding]; other site 593907006759 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 593907006760 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 593907006761 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 593907006762 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 593907006763 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 593907006764 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 593907006765 DNA binding residues [nucleotide binding] 593907006766 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 593907006767 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 593907006768 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 593907006769 DNA binding residues [nucleotide binding] 593907006770 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 593907006771 putative metal binding residues [ion binding]; other site 593907006772 signature motif; other site 593907006773 dimer interface [polypeptide binding]; other site 593907006774 polyP binding site; other site 593907006775 active site 593907006776 substrate binding site [chemical binding]; other site 593907006777 acceptor-phosphate pocket; other site 593907006778 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 593907006779 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 593907006780 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 593907006781 DNA binding residues [nucleotide binding] 593907006782 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 593907006783 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 593907006784 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 593907006785 DNA binding residues [nucleotide binding] 593907006786 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 593907006787 FeS/SAM binding site; other site 593907006788 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 593907006789 Class III ribonucleotide reductase; Region: RNR_III; cd01675 593907006790 effector binding site; other site 593907006791 active site 593907006792 Zn binding site [ion binding]; other site 593907006793 glycine loop; other site 593907006794 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 593907006795 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 593907006796 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 593907006797 LamB/YcsF family; Region: LamB_YcsF; cl00664 593907006798 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 593907006799 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 593907006800 ATP binding site [chemical binding]; other site 593907006801 putative Mg++ binding site [ion binding]; other site 593907006802 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 593907006803 nucleotide binding region [chemical binding]; other site 593907006804 ATP-binding site [chemical binding]; other site 593907006805 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 593907006806 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 593907006807 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 593907006808 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 593907006809 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 593907006810 Walker A/P-loop; other site 593907006811 ATP binding site [chemical binding]; other site 593907006812 Q-loop/lid; other site 593907006813 ABC transporter signature motif; other site 593907006814 Walker B; other site 593907006815 D-loop; other site 593907006816 H-loop/switch region; other site 593907006817 ABC-2 type transporter; Region: ABC2_membrane; cl11417 593907006818 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 593907006819 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 593907006820 ATP binding site [chemical binding]; other site 593907006821 Walker A motif; other site 593907006822 hexamer interface [polypeptide binding]; other site 593907006823 Walker B motif; other site 593907006824 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 593907006825 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 593907006826 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 593907006827 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 593907006828 Malic enzyme, N-terminal domain; Region: malic; pfam00390 593907006829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907006830 NAD(P) binding pocket [chemical binding]; other site 593907006831 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 593907006832 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 593907006833 active site 593907006834 FMN binding site [chemical binding]; other site 593907006835 substrate binding site [chemical binding]; other site 593907006836 homotetramer interface [polypeptide binding]; other site 593907006837 catalytic residue [active] 593907006838 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 593907006839 acetyl-CoA synthetase; Provisional; Region: PRK00174 593907006840 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 593907006841 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 593907006842 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 593907006843 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 593907006844 Cellulose binding domain; Region: CBM_2; cl02709 593907006845 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 593907006846 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 593907006847 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 593907006848 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 593907006849 Coenzyme A binding pocket [chemical binding]; other site 593907006850 polyphosphate kinase; Provisional; Region: PRK05443 593907006851 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 593907006852 putative domain interface [polypeptide binding]; other site 593907006853 putative active site [active] 593907006854 catalytic site [active] 593907006855 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 593907006856 putative active site [active] 593907006857 catalytic site [active] 593907006858 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 593907006859 active site 593907006860 Ap6A binding site [chemical binding]; other site 593907006861 nudix motif; other site 593907006862 metal binding site [ion binding]; metal-binding site 593907006863 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 593907006864 catalytic core [active] 593907006865 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 593907006866 Phosphate transporter family; Region: PHO4; cl00396 593907006867 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 593907006868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 593907006869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 593907006870 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907006871 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 593907006872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 593907006873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 593907006874 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907006875 SelR domain; Region: SelR; cl00369 593907006876 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 593907006877 metal binding site [ion binding]; metal-binding site 593907006878 active site 593907006879 I-site; other site 593907006880 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 593907006881 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 593907006882 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 593907006883 Catalytic site [active] 593907006884 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 593907006885 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 593907006886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 593907006887 dimer interface [polypeptide binding]; other site 593907006888 phosphorylation site [posttranslational modification] 593907006889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 593907006890 ATP binding site [chemical binding]; other site 593907006891 Mg2+ binding site [ion binding]; other site 593907006892 G-X-G motif; other site 593907006893 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 593907006894 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 593907006895 DXD motif; other site 593907006896 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 593907006897 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 593907006898 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 593907006899 Response regulator receiver domain; Region: Response_reg; pfam00072 593907006900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 593907006901 active site 593907006902 phosphorylation site [posttranslational modification] 593907006903 intermolecular recognition site; other site 593907006904 dimerization interface [polypeptide binding]; other site 593907006905 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 593907006906 CE1758 family; Region: LLM_CE1758_fam; TIGR04036 593907006907 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 593907006908 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 593907006909 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 593907006910 ApbE family; Region: ApbE; cl00643 593907006911 FMN-binding domain; Region: FMN_bind; cl01081 593907006912 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 593907006913 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 593907006914 FAD binding pocket [chemical binding]; other site 593907006915 conserved FAD binding motif [chemical binding]; other site 593907006916 phosphate binding motif [ion binding]; other site 593907006917 beta-alpha-beta structure motif; other site 593907006918 NAD binding pocket [chemical binding]; other site 593907006919 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 593907006920 dimer interface [polypeptide binding]; other site 593907006921 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 593907006922 nudix motif; other site 593907006923 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 593907006924 Cellulose binding domain; Region: CBM_2; cl02709 593907006925 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 593907006926 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 593907006927 NAD(P) binding site [chemical binding]; other site 593907006928 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 593907006929 dimerization interface [polypeptide binding]; other site 593907006930 putative DNA binding site [nucleotide binding]; other site 593907006931 putative Zn2+ binding site [ion binding]; other site 593907006932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 593907006933 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 593907006934 putative sugar binding sites [chemical binding]; other site 593907006935 Q-X-W motif; other site 593907006936 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 593907006937 active site 593907006938 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 593907006939 H+ Antiporter protein; Region: 2A0121; TIGR00900 593907006940 H+ Antiporter protein; Region: 2A0121; TIGR00900 593907006941 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 593907006942 dimerization interface [polypeptide binding]; other site 593907006943 putative DNA binding site [nucleotide binding]; other site 593907006944 putative Zn2+ binding site [ion binding]; other site 593907006945 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 593907006946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907006947 NAD(P) binding site [chemical binding]; other site 593907006948 active site 593907006949 maltose O-acetyltransferase; Provisional; Region: PRK10092 593907006950 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 593907006951 active site 593907006952 substrate binding site [chemical binding]; other site 593907006953 trimer interface [polypeptide binding]; other site 593907006954 CoA binding site [chemical binding]; other site 593907006955 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 593907006956 putative dimer interface [polypeptide binding]; other site 593907006957 Helix-turn-helix domain; Region: HTH_18; pfam12833 593907006958 Peptidase family M23; Region: Peptidase_M23; pfam01551 593907006959 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 593907006960 dimerization interface [polypeptide binding]; other site 593907006961 putative DNA binding site [nucleotide binding]; other site 593907006962 putative Zn2+ binding site [ion binding]; other site 593907006963 Predicted permease; Region: DUF318; cl00487 593907006964 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 593907006965 Low molecular weight phosphatase family; Region: LMWPc; cl00105 593907006966 Active site [active] 593907006967 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 593907006968 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 593907006969 Membrane transport protein; Region: Mem_trans; cl09117 593907006970 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 593907006971 dimerization interface [polypeptide binding]; other site 593907006972 putative DNA binding site [nucleotide binding]; other site 593907006973 putative Zn2+ binding site [ion binding]; other site 593907006974 Low molecular weight phosphatase family; Region: LMWPc; cl00105 593907006975 Active site [active] 593907006976 Low molecular weight phosphatase family; Region: LMWPc; cd00115 593907006977 Active site [active] 593907006978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 593907006979 S-adenosylmethionine binding site [chemical binding]; other site 593907006980 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 593907006981 dimerization interface [polypeptide binding]; other site 593907006982 putative DNA binding site [nucleotide binding]; other site 593907006983 putative Zn2+ binding site [ion binding]; other site 593907006984 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907006985 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 593907006986 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 593907006987 non-specific DNA binding site [nucleotide binding]; other site 593907006988 salt bridge; other site 593907006989 sequence-specific DNA binding site [nucleotide binding]; other site 593907006990 Cupin domain; Region: Cupin_2; cl09118 593907006991 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 593907006992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 593907006993 S-adenosylmethionine binding site [chemical binding]; other site 593907006994 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 593907006995 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 593907006996 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907006997 NAD(P) binding site [chemical binding]; other site 593907006998 active site 593907006999 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 593907007000 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 593907007001 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 593907007002 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 593907007003 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 593907007004 DNA binding residues [nucleotide binding] 593907007005 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 593907007006 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 593907007007 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 593907007008 dimerization interface [polypeptide binding]; other site 593907007009 putative ATP binding site [chemical binding]; other site 593907007010 amidophosphoribosyltransferase; Provisional; Region: PRK07847 593907007011 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 593907007012 active site 593907007013 tetramer interface [polypeptide binding]; other site 593907007014 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 593907007015 Cellulose binding domain; Region: CBM_2; cl02709 593907007016 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 593907007017 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 593907007018 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as...; Region: OYE_like_FMN_family; cd02803 593907007019 active site 593907007020 FMN binding site [chemical binding]; other site 593907007021 substrate binding site [chemical binding]; other site 593907007022 putative catalytic residue [active] 593907007023 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 593907007024 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 593907007025 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 593907007026 GTPase/OB domain interface [polypeptide binding]; other site 593907007027 GTPase/Zn-binding domain interface [polypeptide binding]; other site 593907007028 GTP/Mg2+ binding site [chemical binding]; other site 593907007029 G4 box; other site 593907007030 G5 box; other site 593907007031 G1 box; other site 593907007032 Switch I region; other site 593907007033 G2 box; other site 593907007034 G3 box; other site 593907007035 Switch II region; other site 593907007036 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 593907007037 Protein of unknown function, DUF488; Region: DUF488; cl01246 593907007038 glutamate dehydrogenase; Provisional; Region: PRK09414 593907007039 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 593907007040 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 593907007041 NAD(P) binding site [chemical binding]; other site 593907007042 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 593907007043 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 593907007044 dimerization interface [polypeptide binding]; other site 593907007045 ATP binding site [chemical binding]; other site 593907007046 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 593907007047 dimerization interface [polypeptide binding]; other site 593907007048 ATP binding site [chemical binding]; other site 593907007049 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 593907007050 acyl-coenzyme A oxidase; Region: PLN02636 593907007051 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 593907007052 active site 593907007053 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 593907007054 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 593907007055 dimer interface [polypeptide binding]; other site 593907007056 active site 593907007057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907007058 NAD(P) binding site [chemical binding]; other site 593907007059 active site 593907007060 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 593907007061 active site 2 [active] 593907007062 active site 1 [active] 593907007063 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 593907007064 2-phosphoglycerate kinase [Carbohydrate transport and metabolism]; Region: COG2074 593907007065 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907007066 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 593907007067 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 593907007068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 593907007069 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 593907007070 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 593907007071 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 593907007072 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 593907007073 catalytic residue [active] 593907007074 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 593907007075 active site residue [active] 593907007076 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 593907007077 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 593907007078 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 593907007079 catalytic residue [active] 593907007080 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907007081 Walker A/P-loop; other site 593907007082 ATP binding site [chemical binding]; other site 593907007083 Q-loop/lid; other site 593907007084 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14273 593907007085 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 593907007086 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907007087 Walker A/P-loop; other site 593907007088 ATP binding site [chemical binding]; other site 593907007089 Q-loop/lid; other site 593907007090 ABC transporter signature motif; other site 593907007091 Walker B; other site 593907007092 D-loop; other site 593907007093 H-loop/switch region; other site 593907007094 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 593907007095 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 593907007096 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 593907007097 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 593907007098 Coenzyme A binding pocket [chemical binding]; other site 593907007099 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 593907007100 putative active site [active] 593907007101 catalytic triad [active] 593907007102 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 593907007103 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 593907007104 active site 593907007105 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 593907007106 active site 593907007107 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 593907007108 active site 593907007109 ATP binding site [chemical binding]; other site 593907007110 substrate binding site [chemical binding]; other site 593907007111 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 593907007112 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 593907007113 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 593907007114 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 593907007115 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 593907007116 dimerization interface [polypeptide binding]; other site 593907007117 putative DNA binding site [nucleotide binding]; other site 593907007118 putative Zn2+ binding site [ion binding]; other site 593907007119 H+ Antiporter protein; Region: 2A0121; TIGR00900 593907007120 adenylosuccinate synthetase; Provisional; Region: PRK01117 593907007121 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 593907007122 GDP-binding site [chemical binding]; other site 593907007123 ACT binding site; other site 593907007124 IMP binding site; other site 593907007125 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 593907007126 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 593907007127 anti sigma factor interaction site; other site 593907007128 regulatory phosphorylation site [posttranslational modification]; other site 593907007129 PAS domain S-box; Region: sensory_box; TIGR00229 593907007130 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 593907007131 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 593907007132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 593907007133 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 593907007134 anti sigma factor interaction site; other site 593907007135 regulatory phosphorylation site [posttranslational modification]; other site 593907007136 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 593907007137 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 593907007138 active site 593907007139 intersubunit interface [polypeptide binding]; other site 593907007140 zinc binding site [ion binding]; other site 593907007141 Na+ binding site [ion binding]; other site 593907007142 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 593907007143 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 593907007144 UMP phosphatase; Provisional; Region: PRK10444 593907007145 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 593907007146 active site 593907007147 motif I; other site 593907007148 motif II; other site 593907007149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 593907007150 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 593907007151 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 593907007152 classical (c) SDRs; Region: SDR_c; cd05233 593907007153 NAD(P) binding site [chemical binding]; other site 593907007154 active site 593907007155 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 593907007156 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 593907007157 ATP binding site [chemical binding]; other site 593907007158 putative Mg++ binding site [ion binding]; other site 593907007159 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 593907007160 nucleotide binding region [chemical binding]; other site 593907007161 ATP-binding site [chemical binding]; other site 593907007162 RQC domain; Region: RQC; pfam09382 593907007163 HRDC domain; Region: HRDC; cl02578 593907007164 Domain of unknown function (DU1801); Region: DUF1801; cl01838 593907007165 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl14635 593907007166 nitrite reductase subunit NirD; Provisional; Region: PRK14989 593907007167 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 593907007168 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 593907007169 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 593907007170 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain...; Region: Rieske_NirD; cd03529 593907007171 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 593907007172 nudix motif; other site 593907007173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907007174 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 593907007175 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 593907007176 active site 593907007177 catalytic tetrad [active] 593907007178 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 593907007179 Transcriptional regulators [Transcription]; Region: PurR; COG1609 593907007180 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 593907007181 DNA binding site [nucleotide binding] 593907007182 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 593907007183 putative dimerization interface [polypeptide binding]; other site 593907007184 putative ligand binding site [chemical binding]; other site 593907007185 Beta-lactamase; Region: Beta-lactamase; cl01009 593907007186 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 593907007187 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 593907007188 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 593907007189 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 593907007190 metal binding site [ion binding]; metal-binding site 593907007191 active site 593907007192 I-site; other site 593907007193 Clp protease ATP binding subunit; Region: clpC; CHL00095 593907007194 Clp amino terminal domain; Region: Clp_N; pfam02861 593907007195 Clp amino terminal domain; Region: Clp_N; pfam02861 593907007196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 593907007197 Walker A motif; other site 593907007198 ATP binding site [chemical binding]; other site 593907007199 Walker B motif; other site 593907007200 arginine finger; other site 593907007201 UvrB/uvrC motif; Region: UVR; pfam02151 593907007202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 593907007203 Walker A motif; other site 593907007204 ATP binding site [chemical binding]; other site 593907007205 Walker B motif; other site 593907007206 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 593907007207 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 593907007208 NAD-dependent deacetylase; Provisional; Region: PRK05333 593907007209 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2-fam; cd01407 593907007210 NAD+ binding site [chemical binding]; other site 593907007211 substrate binding site [chemical binding]; other site 593907007212 Zn binding site [ion binding]; other site 593907007213 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 593907007214 HSP70 interaction site [polypeptide binding]; other site 593907007215 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 593907007216 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 593907007217 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 593907007218 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 593907007219 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 593907007220 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907007221 Walker A/P-loop; other site 593907007222 ATP binding site [chemical binding]; other site 593907007223 Q-loop/lid; other site 593907007224 ABC transporter signature motif; other site 593907007225 Walker B; other site 593907007226 D-loop; other site 593907007227 H-loop/switch region; other site 593907007228 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 593907007229 putative transposase OrfB; Reviewed; Region: PHA02517 593907007230 Integrase core domain; Region: rve; cl01316 593907007231 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 593907007232 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 593907007233 Integrase core domain; Region: rve; cl01316 593907007234 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 593907007235 multiple promoter invertase; Provisional; Region: mpi; PRK13413 593907007236 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 593907007237 catalytic residues [active] 593907007238 catalytic nucleophile [active] 593907007239 Presynaptic Site I dimer interface [polypeptide binding]; other site 593907007240 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 593907007241 Synaptic Flat tetramer interface [polypeptide binding]; other site 593907007242 Synaptic Site I dimer interface [polypeptide binding]; other site 593907007243 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 593907007244 mercuric reductase; Region: MerA; TIGR02053 593907007245 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 593907007246 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 593907007247 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 593907007248 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 593907007249 DNA binding residues [nucleotide binding] 593907007250 dimer interface [polypeptide binding]; other site 593907007251 metal binding site [ion binding]; metal-binding site 593907007252 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 593907007253 Cation efflux family; Region: Cation_efflux; cl00316 593907007254 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 593907007255 dimerization interface [polypeptide binding]; other site 593907007256 putative DNA binding site [nucleotide binding]; other site 593907007257 putative Zn2+ binding site [ion binding]; other site 593907007258 Domain of unknown function (DUF305); Region: DUF305; pfam03713 593907007259 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 593907007260 dimerization interface [polypeptide binding]; other site 593907007261 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 593907007262 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 593907007263 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 593907007264 Ycf48-like protein; Provisional; Region: PRK13684 593907007265 Domain of unknown function (DUF305); Region: DUF305; pfam03713 593907007266 Domain of unknown function (DUF305); Region: DUF305; pfam03713 593907007267 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 593907007268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 593907007269 active site 593907007270 phosphorylation site [posttranslational modification] 593907007271 intermolecular recognition site; other site 593907007272 dimerization interface [polypeptide binding]; other site 593907007273 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 593907007274 DNA binding site [nucleotide binding] 593907007275 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 593907007276 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 593907007277 dimer interface [polypeptide binding]; other site 593907007278 phosphorylation site [posttranslational modification] 593907007279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 593907007280 ATP binding site [chemical binding]; other site 593907007281 Mg2+ binding site [ion binding]; other site 593907007282 G-X-G motif; other site 593907007283 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 593907007284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 593907007285 active site 593907007286 phosphorylation site [posttranslational modification] 593907007287 intermolecular recognition site; other site 593907007288 dimerization interface [polypeptide binding]; other site 593907007289 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 593907007290 DNA binding site [nucleotide binding] 593907007291 Phosphotransferase enzyme family; Region: APH; pfam01636 593907007292 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 593907007293 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 593907007294 putative active site [active] 593907007295 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 593907007296 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 593907007297 active site 593907007298 motif I; other site 593907007299 motif II; other site 593907007300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 593907007301 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 593907007302 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 593907007303 putative ADP-ribose binding site [chemical binding]; other site 593907007304 putative active site [active] 593907007305 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which...; Region: SERPIN; cl00137 593907007306 reactive center loop; other site 593907007307 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 593907007308 putative active site [active] 593907007309 dimerization interface [polypeptide binding]; other site 593907007310 putative tRNAtyr binding site [nucleotide binding]; other site 593907007311 L-asparaginase II; Region: Asparaginase_II; cl01842 593907007312 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 593907007313 Predicted membrane protein [Function unknown]; Region: COG4129 593907007314 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 593907007315 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 593907007316 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 593907007317 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 593907007318 heme-binding site [chemical binding]; other site 593907007319 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 593907007320 DNA binding site [nucleotide binding] 593907007321 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 593907007322 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 593907007323 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 593907007324 minor groove reading motif; other site 593907007325 helix-hairpin-helix signature motif; other site 593907007326 substrate binding pocket [chemical binding]; other site 593907007327 active site 593907007328 FES domain; Region: FES; smart00525 593907007329 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 593907007330 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 593907007331 ligand binding site [chemical binding]; other site 593907007332 flexible hinge region; other site 593907007333 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 593907007334 putative switch regulator; other site 593907007335 non-specific DNA interactions [nucleotide binding]; other site 593907007336 DNA binding site [nucleotide binding] 593907007337 sequence specific DNA binding site [nucleotide binding]; other site 593907007338 putative cAMP binding site [chemical binding]; other site 593907007339 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 593907007340 homotrimer interaction site [polypeptide binding]; other site 593907007341 putative active site [active] 593907007342 Transcription factor WhiB; Region: Whib; pfam02467 593907007343 Transglycosylase; Region: Transgly; cl07896 593907007344 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 593907007345 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 593907007346 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 593907007347 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 593907007348 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 593907007349 putative active site [active] 593907007350 putative metal binding site [ion binding]; other site 593907007351 Histidine kinase; Region: HisKA_3; pfam07730 593907007352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 593907007353 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 593907007354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907007355 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 593907007356 aspartate kinase; Reviewed; Region: PRK06635 593907007357 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 593907007358 putative nucleotide binding site [chemical binding]; other site 593907007359 putative catalytic residues [active] 593907007360 putative Mg ion binding site [ion binding]; other site 593907007361 putative aspartate binding site [chemical binding]; other site 593907007362 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 593907007363 putative allosteric regulatory site; other site 593907007364 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 593907007365 putative allosteric regulatory residue; other site 593907007366 PAS domain S-box; Region: sensory_box; TIGR00229 593907007367 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 593907007368 putative active site [active] 593907007369 heme pocket [chemical binding]; other site 593907007370 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 593907007371 putative active site [active] 593907007372 heme pocket [chemical binding]; other site 593907007373 PAS domain S-box; Region: sensory_box; TIGR00229 593907007374 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 593907007375 putative active site [active] 593907007376 heme pocket [chemical binding]; other site 593907007377 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 593907007378 metal binding site [ion binding]; metal-binding site 593907007379 active site 593907007380 I-site; other site 593907007381 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 593907007382 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 593907007383 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 593907007384 Walker A/P-loop; other site 593907007385 ATP binding site [chemical binding]; other site 593907007386 Q-loop/lid; other site 593907007387 ABC transporter signature motif; other site 593907007388 Walker B; other site 593907007389 D-loop; other site 593907007390 H-loop/switch region; other site 593907007391 ABC-2 type transporter; Region: ABC2_membrane; cl11417 593907007392 recombination protein RecR; Reviewed; Region: recR; PRK00076 593907007393 RecR protein; Region: RecR; pfam02132 593907007394 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 593907007395 putative active site [active] 593907007396 putative metal-binding site [ion binding]; other site 593907007397 tetramer interface [polypeptide binding]; other site 593907007398 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 593907007399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 593907007400 Walker A motif; other site 593907007401 ATP binding site [chemical binding]; other site 593907007402 Walker B motif; other site 593907007403 arginine finger; other site 593907007404 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 593907007405 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907007406 Predicted ATPase [General function prediction only]; Region: COG3910 593907007407 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 593907007408 Walker A/P-loop; other site 593907007409 ATP binding site [chemical binding]; other site 593907007410 Q-loop/lid; other site 593907007411 ABC transporter signature motif; other site 593907007412 Walker B; other site 593907007413 D-loop; other site 593907007414 H-loop/switch region; other site 593907007415 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 593907007416 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 593907007417 active site 593907007418 metal binding site [ion binding]; metal-binding site 593907007419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 593907007420 ATP binding site [chemical binding]; other site 593907007421 Mg2+ binding site [ion binding]; other site 593907007422 G-X-G motif; other site 593907007423 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 593907007424 ATP binding site [chemical binding]; other site 593907007425 putative Mg++ binding site [ion binding]; other site 593907007426 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 593907007427 nucleotide binding region [chemical binding]; other site 593907007428 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 593907007429 mismatch recognition site; other site 593907007430 additional DNA contacts [nucleotide binding]; other site 593907007431 active site 593907007432 zinc binding site [ion binding]; other site 593907007433 DNA intercalation site [nucleotide binding]; other site 593907007434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 593907007435 cofactor binding site; other site 593907007436 DNA binding site [nucleotide binding] 593907007437 substrate interaction site [chemical binding]; other site 593907007438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 593907007439 DinB superfamily; Region: DinB_2; cl00986 593907007440 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 593907007441 conserved cys residue [active] 593907007442 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 593907007443 DNA-binding site [nucleotide binding]; DNA binding site 593907007444 RNA-binding motif; other site 593907007445 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 593907007446 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 593907007447 Sulfate transporter family; Region: Sulfate_transp; cl00967 593907007448 Permease family; Region: Xan_ur_permease; pfam00860 593907007449 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 593907007450 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 593907007451 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 593907007452 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 593907007453 putative DNA binding site [nucleotide binding]; other site 593907007454 catalytic residue [active] 593907007455 putative H2TH interface [polypeptide binding]; other site 593907007456 putative catalytic residues [active] 593907007457 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 593907007458 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 593907007459 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907007460 Peptidase family M41; Region: Peptidase_M41; pfam01434 593907007461 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; cl06815 593907007462 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 593907007463 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 593907007464 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 593907007465 catalytic residues [active] 593907007466 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 593907007467 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 593907007468 Walker A/P-loop; other site 593907007469 ATP binding site [chemical binding]; other site 593907007470 Q-loop/lid; other site 593907007471 ABC transporter signature motif; other site 593907007472 Walker B; other site 593907007473 D-loop; other site 593907007474 H-loop/switch region; other site 593907007475 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 593907007476 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 593907007477 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 593907007478 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907007479 ATP binding site [chemical binding]; other site 593907007480 Q-loop/lid; other site 593907007481 ABC transporter signature motif; other site 593907007482 Walker B; other site 593907007483 D-loop; other site 593907007484 H-loop/switch region; other site 593907007485 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 593907007486 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 593907007487 Walker A/P-loop; other site 593907007488 ATP binding site [chemical binding]; other site 593907007489 Q-loop/lid; other site 593907007490 ABC transporter signature motif; other site 593907007491 Walker B; other site 593907007492 D-loop; other site 593907007493 H-loop/switch region; other site 593907007494 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 593907007495 NAD-dependent deacetylase; Provisional; Region: PRK05333 593907007496 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 593907007497 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 593907007498 nucleoside/Zn binding site; other site 593907007499 dimer interface [polypeptide binding]; other site 593907007500 catalytic motif [active] 593907007501 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 593907007502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907007503 NAD(P) binding site [chemical binding]; other site 593907007504 active site 593907007505 RNA polymerase sigma factor; Provisional; Region: PRK12519 593907007506 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 593907007507 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 593907007508 DNA binding residues [nucleotide binding] 593907007509 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 593907007510 active site 593907007511 substrate binding site [chemical binding]; other site 593907007512 ATP binding site [chemical binding]; other site 593907007513 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 593907007514 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 593907007515 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 593907007516 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 593907007517 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907007518 potential frameshift: common BLAST hit: gi|332672259|ref|YP_004455267.1| ABC transporter-like protein 593907007519 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 593907007520 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907007521 Walker A/P-loop; other site 593907007522 ATP binding site [chemical binding]; other site 593907007523 ABC transporter signature motif; other site 593907007524 Walker B; other site 593907007525 D-loop; other site 593907007526 H-loop/switch region; other site 593907007527 ABC transporter; Region: ABC_tran_2; pfam12848 593907007528 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907007529 Walker A/P-loop; other site 593907007530 ATP binding site [chemical binding]; other site 593907007531 Q-loop/lid; other site 593907007532 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 593907007533 FtsX-like permease family; Region: FtsX; pfam02687 593907007534 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 593907007535 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 593907007536 Walker A/P-loop; other site 593907007537 ATP binding site [chemical binding]; other site 593907007538 Q-loop/lid; other site 593907007539 ABC transporter signature motif; other site 593907007540 Walker B; other site 593907007541 D-loop; other site 593907007542 H-loop/switch region; other site 593907007543 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 593907007544 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 593907007545 active site 593907007546 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 593907007547 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 593907007548 dimer interface [polypeptide binding]; other site 593907007549 putative radical transfer pathway; other site 593907007550 diiron center [ion binding]; other site 593907007551 tyrosyl radical; other site 593907007552 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl14912 593907007553 DNA binding site [nucleotide binding] 593907007554 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 593907007555 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 593907007556 Class I ribonucleotide reductase; Region: RNR_I; cd01679 593907007557 active site 593907007558 dimer interface [polypeptide binding]; other site 593907007559 catalytic residues [active] 593907007560 effector binding site; other site 593907007561 R2 peptide binding site; other site 593907007562 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 593907007563 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 593907007564 catalytic residues [active] 593907007565 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 593907007566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907007567 NAD(P) binding site [chemical binding]; other site 593907007568 active site 593907007569 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907007570 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 593907007571 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907007572 ABC-2 type transporter; Region: ABC2_membrane; cl11417 593907007573 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907007574 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 593907007575 Walker A/P-loop; other site 593907007576 ATP binding site [chemical binding]; other site 593907007577 Q-loop/lid; other site 593907007578 ABC transporter signature motif; other site 593907007579 Walker B; other site 593907007580 D-loop; other site 593907007581 H-loop/switch region; other site 593907007582 PAS fold; Region: PAS_2; pfam08446 593907007583 GAF domain; Region: GAF; cl00853 593907007584 Phytochrome region; Region: PHY; pfam00360 593907007585 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 593907007586 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 593907007587 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 593907007588 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 593907007589 DNA binding residues [nucleotide binding] 593907007590 putative dimer interface [polypeptide binding]; other site 593907007591 chaperone protein DnaJ; Provisional; Region: PRK14299 593907007592 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 593907007593 HSP70 interaction site [polypeptide binding]; other site 593907007594 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 593907007595 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 593907007596 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 593907007597 dimer interface [polypeptide binding]; other site 593907007598 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 593907007599 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 593907007600 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 593907007601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 593907007602 cofactor binding site; other site 593907007603 DNA binding site [nucleotide binding] 593907007604 substrate interaction site [chemical binding]; other site 593907007605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 593907007606 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 593907007607 ATP-dependent DNA helicase RecG; Region: recG; TIGR00643 593907007608 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 593907007609 ATP-binding site [chemical binding]; other site 593907007610 UvrD/REP helicase; Region: UvrD-helicase; cl14126 593907007611 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 593907007612 UvrD/REP helicase; Region: UvrD-helicase; cl14126 593907007613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 593907007614 ATP binding site [chemical binding]; other site 593907007615 Mg2+ binding site [ion binding]; other site 593907007616 G-X-G motif; other site 593907007617 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 593907007618 ATP binding site [chemical binding]; other site 593907007619 putative Mg++ binding site [ion binding]; other site 593907007620 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 593907007621 nucleotide binding region [chemical binding]; other site 593907007622 ATP-binding site [chemical binding]; other site 593907007623 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 593907007624 putative active site [active] 593907007625 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 593907007626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 593907007627 cofactor binding site; other site 593907007628 DNA binding site [nucleotide binding] 593907007629 substrate interaction site [chemical binding]; other site 593907007630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 593907007631 Protein of unknown function DUF262; Region: DUF262; cl14890 593907007632 Protein of unknown function DUF262; Region: DUF262; cl14890 593907007633 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 593907007634 DNA binding site [nucleotide binding] 593907007635 active site 593907007636 Nuclease-related domain; Region: NERD; pfam08378 593907007637 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 593907007638 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 593907007639 active site 593907007640 substrate binding site [chemical binding]; other site 593907007641 ATP binding site [chemical binding]; other site 593907007642 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 593907007643 active site 593907007644 Isochorismatase family; Region: Isochorismatase; pfam00857 593907007645 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 593907007646 catalytic triad [active] 593907007647 conserved cis-peptide bond; other site 593907007648 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907007649 Cellulose binding domain; Region: CBM_2; cl02709 593907007650 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 593907007651 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 593907007652 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 593907007653 active site 593907007654 catalytic triad [active] 593907007655 oxyanion hole [active] 593907007656 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 593907007657 putative sugar binding sites [chemical binding]; other site 593907007658 Q-X-W motif; other site 593907007659 YCII-related domain; Region: YCII; cl00999 593907007660 Predicted transcriptional regulator [Transcription]; Region: COG2378 593907007661 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907007662 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 593907007663 active site 593907007664 metal binding site [ion binding]; metal-binding site 593907007665 Cellulose binding domain; Region: CBM_2; cl02709 593907007666 Fasciclin domain; Region: Fasciclin; cl02663 593907007667 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 593907007668 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 593907007669 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 593907007670 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 593907007671 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907007672 Predicted transcriptional regulator [Transcription]; Region: COG2378 593907007673 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 593907007674 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 593907007675 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 593907007676 DNA-binding site [nucleotide binding]; DNA binding site 593907007677 RNA-binding motif; other site 593907007678 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 593907007679 DNA-binding site [nucleotide binding]; DNA binding site 593907007680 RNA-binding motif; other site 593907007681 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 593907007682 DNA-binding site [nucleotide binding]; DNA binding site 593907007683 RNA-binding motif; other site 593907007684 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 593907007685 DNA-binding site [nucleotide binding]; DNA binding site 593907007686 RNA-binding motif; other site 593907007687 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 593907007688 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 593907007689 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907007690 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 593907007691 active site residue [active] 593907007692 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907007693 Active site [active] 593907007694 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907007695 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 593907007696 ligand binding site [chemical binding]; other site 593907007697 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 593907007698 putative metal binding site [ion binding]; other site 593907007699 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 593907007700 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 593907007701 putative metal binding site [ion binding]; other site 593907007702 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 593907007703 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 593907007704 putative metal binding site [ion binding]; other site 593907007705 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 593907007706 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907007707 NAD(P) binding site [chemical binding]; other site 593907007708 active site 593907007709 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 593907007710 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907007711 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 593907007712 putative hydrophobic ligand binding site [chemical binding]; other site 593907007713 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 593907007714 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical...; Region: CHS_like; cd00831 593907007715 malonyl-CoA binding site [chemical binding]; other site 593907007716 dimer interface [polypeptide binding]; other site 593907007717 active site 593907007718 product binding site; other site 593907007719 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 593907007720 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 593907007721 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 593907007722 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907007723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 593907007724 maltose O-acetyltransferase; Provisional; Region: PRK10092 593907007725 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 593907007726 active site 593907007727 substrate binding site [chemical binding]; other site 593907007728 trimer interface [polypeptide binding]; other site 593907007729 CoA binding site [chemical binding]; other site 593907007730 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 593907007731 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907007732 Active site [active] 593907007733 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 593907007734 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 593907007735 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 593907007736 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 593907007737 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 593907007738 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 593907007739 catalytic Zn binding site [ion binding]; other site 593907007740 NAD(P) binding site [chemical binding]; other site 593907007741 structural Zn binding site [ion binding]; other site 593907007742 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 593907007743 active site 593907007744 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 593907007745 Cellulose binding domain; Region: CBM_2; cl02709 593907007746 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 593907007747 Cellulose binding domain; Region: CBM_2; cl02709 593907007748 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907007749 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 593907007750 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 593907007751 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907007752 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 593907007753 Walker A/P-loop; other site 593907007754 ATP binding site [chemical binding]; other site 593907007755 Q-loop/lid; other site 593907007756 ABC transporter signature motif; other site 593907007757 Walker B; other site 593907007758 D-loop; other site 593907007759 H-loop/switch region; other site 593907007760 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 593907007761 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907007762 Walker A/P-loop; other site 593907007763 ATP binding site [chemical binding]; other site 593907007764 Q-loop/lid; other site 593907007765 ABC transporter signature motif; other site 593907007766 Walker B; other site 593907007767 D-loop; other site 593907007768 H-loop/switch region; other site 593907007769 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 593907007770 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 593907007771 inhibitor binding site; inhibition site 593907007772 active site 593907007773 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 593907007774 metal binding site [ion binding]; metal-binding site 593907007775 active site 593907007776 I-site; other site 593907007777 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 593907007778 CrcB-like protein; Region: CRCB; cl09114 593907007779 CrcB-like protein; Region: CRCB; cl09114 593907007780 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 593907007781 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cl00436 593907007782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907007783 NAD(P) binding site [chemical binding]; other site 593907007784 active site 593907007785 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 593907007786 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 593907007787 putative DNA binding site [nucleotide binding]; other site 593907007788 dimerization interface [polypeptide binding]; other site 593907007789 putative Zn2+ binding site [ion binding]; other site 593907007790 Cation efflux family; Region: Cation_efflux; cl00316 593907007791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 593907007792 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 593907007793 putative substrate translocation pore; other site 593907007794 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 593907007795 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 593907007796 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 593907007797 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 593907007798 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate...; Region: MopB_Nitrate-R-NarG-like; cd02750 593907007799 [4Fe-4S] binding site [ion binding]; other site 593907007800 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 593907007801 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 593907007802 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 593907007803 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 593907007804 molybdopterin cofactor binding site; other site 593907007805 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 593907007806 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 593907007807 Zn binding site [ion binding]; other site 593907007808 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907007809 Active site [active] 593907007810 H+ Antiporter protein; Region: 2A0121; TIGR00900 593907007811 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 593907007812 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 593907007813 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 593907007814 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 593907007815 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 593907007816 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 593907007817 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907007818 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 593907007819 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907007820 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 593907007821 Walker A/P-loop; other site 593907007822 ATP binding site [chemical binding]; other site 593907007823 Q-loop/lid; other site 593907007824 ABC transporter signature motif; other site 593907007825 Walker B; other site 593907007826 D-loop; other site 593907007827 H-loop/switch region; other site 593907007828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907007829 dimer interface [polypeptide binding]; other site 593907007830 conserved gate region; other site 593907007831 ABC-ATPase subunit interface; other site 593907007832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 593907007833 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 593907007834 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907007835 methionine aminopeptidase; Reviewed; Region: PRK07281 593907007836 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 593907007837 active site 593907007838 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 593907007839 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 593907007840 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 593907007841 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 593907007842 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 593907007843 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 593907007844 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 593907007845 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 593907007846 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 593907007847 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 593907007848 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 593907007849 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 593907007850 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 593907007851 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 593907007852 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 593907007853 Cysteine-rich domain; Region: CCG; pfam02754 593907007854 Cysteine-rich domain; Region: CCG; pfam02754 593907007855 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 593907007856 trimer interface [polypeptide binding]; other site 593907007857 active site 593907007858 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 593907007859 Putative carbohydrate binding domain; Region: CBM_X; pfam06204 593907007860 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 593907007861 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 593907007862 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 593907007863 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 593907007864 active site 593907007865 catalytic residues [active] 593907007866 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 593907007867 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 593907007868 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 593907007869 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 593907007870 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 593907007871 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 593907007872 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 593907007873 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 593907007874 Domain of unknown function (DUF404); Region: DUF404; pfam04169 593907007875 Domain of unknown function (DUF407); Region: DUF407; pfam04174 593907007876 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 593907007877 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 593907007878 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 593907007879 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 593907007880 DinB superfamily; Region: DinB_2; cl00986 593907007881 Protein of unknown function (DUF779); Region: DUF779; cl01432 593907007882 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 593907007883 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 593907007884 NAD(P) binding site [chemical binding]; other site 593907007885 catalytic residues [active] 593907007886 endonuclease IV; Provisional; Region: PRK01060 593907007887 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 593907007888 AP (apurinic/apyrimidinic) site pocket; other site 593907007889 DNA interaction; other site 593907007890 Metal-binding active site; metal-binding site 593907007891 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 593907007892 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 593907007893 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 593907007894 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 593907007895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 593907007896 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 593907007897 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 593907007898 NHL repeat; Region: NHL; pfam01436 593907007899 GAF domain; Region: GAF; cl00853 593907007900 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 593907007901 metal binding site [ion binding]; metal-binding site 593907007902 active site 593907007903 I-site; other site 593907007904 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 593907007905 heme binding pocket [chemical binding]; other site 593907007906 heme ligand [chemical binding]; other site 593907007907 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 593907007908 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 593907007909 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 593907007910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 593907007911 D-galactonate transporter; Region: 2A0114; TIGR00893 593907007912 putative substrate translocation pore; other site 593907007913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 593907007914 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 593907007915 iron-sulfur cluster [ion binding]; other site 593907007916 [2Fe-2S] cluster binding site [ion binding]; other site 593907007917 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 593907007918 catalytic core [active] 593907007919 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 593907007920 E3 interaction surface; other site 593907007921 lipoyl attachment site [posttranslational modification]; other site 593907007922 e3 binding domain; Region: E3_binding; pfam02817 593907007923 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 593907007924 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 593907007925 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 593907007926 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 593907007927 alpha subunit interface [polypeptide binding]; other site 593907007928 TPP binding site [chemical binding]; other site 593907007929 heterodimer interface [polypeptide binding]; other site 593907007930 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 593907007931 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 593907007932 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 593907007933 tetramer interface [polypeptide binding]; other site 593907007934 TPP-binding site [chemical binding]; other site 593907007935 heterodimer interface [polypeptide binding]; other site 593907007936 phosphorylation loop region [posttranslational modification] 593907007937 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 593907007938 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 593907007939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907007940 homodimer interface [polypeptide binding]; other site 593907007941 catalytic residue [active] 593907007942 Membrane protein of unknown function; Region: DUF360; cl00850 593907007943 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 593907007944 Protein of unknown function DUF58; Region: DUF58; pfam01882 593907007945 MoxR-like ATPases [General function prediction only]; Region: COG0714 593907007946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 593907007947 Walker A motif; other site 593907007948 ATP binding site [chemical binding]; other site 593907007949 Walker B motif; other site 593907007950 arginine finger; other site 593907007951 adenylosuccinate lyase; Provisional; Region: PRK09285 593907007952 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 593907007953 tetramer interface [polypeptide binding]; other site 593907007954 active site 593907007955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907007956 NAD(P) binding pocket [chemical binding]; other site 593907007957 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 593907007958 substrate binding site [chemical binding]; other site 593907007959 active site 593907007960 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 593907007961 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 593907007962 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 593907007963 domain interfaces; other site 593907007964 active site 593907007965 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 593907007966 active site 593907007967 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cl00338 593907007968 dimer interface [polypeptide binding]; other site 593907007969 active site 593907007970 Schiff base residues; other site 593907007971 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 593907007972 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 593907007973 inhibitor-cofactor binding pocket; inhibition site 593907007974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907007975 catalytic residue [active] 593907007976 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 593907007977 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 593907007978 Predicted transcriptional regulator [Transcription]; Region: COG1959 593907007979 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907007980 Rrf2 family protein; Region: rrf2_super; TIGR00738 593907007981 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907007982 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907007983 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a solute-...; Region: ABC_CysA_sulfate_importer; cd03296 593907007984 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 593907007985 Walker A/P-loop; other site 593907007986 ATP binding site [chemical binding]; other site 593907007987 Q-loop/lid; other site 593907007988 ABC transporter signature motif; other site 593907007989 Walker B; other site 593907007990 D-loop; other site 593907007991 H-loop/switch region; other site 593907007992 TOBE-like domain; Region: TOBE_3; pfam12857 593907007993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907007994 dimer interface [polypeptide binding]; other site 593907007995 conserved gate region; other site 593907007996 ABC-ATPase subunit interface; other site 593907007997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 593907007998 dimer interface [polypeptide binding]; other site 593907007999 conserved gate region; other site 593907008000 putative PBP binding loops; other site 593907008001 ABC-ATPase subunit interface; other site 593907008002 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 593907008003 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 593907008004 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 593907008005 putative homotetramer interface [polypeptide binding]; other site 593907008006 putative homodimer interface [polypeptide binding]; other site 593907008007 putative allosteric switch controlling residues; other site 593907008008 putative metal binding site [ion binding]; other site 593907008009 putative homodimer-homodimer interface [polypeptide binding]; other site 593907008010 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 593907008011 metal-binding site [ion binding] 593907008012 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 593907008013 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 593907008014 metal-binding site [ion binding] 593907008015 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 593907008016 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 593907008017 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 593907008018 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 593907008019 Walker A/P-loop; other site 593907008020 ATP binding site [chemical binding]; other site 593907008021 Q-loop/lid; other site 593907008022 ABC transporter signature motif; other site 593907008023 Walker B; other site 593907008024 D-loop; other site 593907008025 H-loop/switch region; other site 593907008026 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 593907008027 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 593907008028 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 593907008029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 593907008030 NAD(P) binding site [chemical binding]; other site 593907008031 active site 593907008032 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 593907008033 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 593907008034 active site 593907008035 catalytic tetrad [active] 593907008036 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 593907008037 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 593907008038 YCII-related domain; Region: YCII; cl00999 593907008039 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 593907008040 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 593907008041 putative NAD(P) binding site [chemical binding]; other site 593907008042 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 593907008043 VPS10 domain; Region: VPS10; smart00602 593907008044 Cellulose binding domain; Region: CBM_2; cl02709 593907008045 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan...; Region: Sortase_E; cd05829 593907008046 active site 593907008047 putative catalytic site [active] 593907008048 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 593907008049 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 593907008050 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 593907008051 DNA binding residues [nucleotide binding] 593907008052 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 593907008053 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 593907008054 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 593907008055 Panthothenate kinase [Coenzyme metabolism]; Region: CoaA; COG1072 593907008056 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907008057 Active site [active] 593907008058 Domain of unknown function (DUF336); Region: DUF336; cl01249 593907008059 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 593907008060 Cellulose binding domain; Region: CBM_2; cl02709 593907008061 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 593907008062 Cytochrome P450; Region: p450; cl12078 593907008063 Domain of unknown function (DUF305); Region: DUF305; pfam03713 593907008064 Domain of unknown function (DUF305); Region: DUF305; pfam03713 593907008065 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 593907008066 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 593907008067 OsmC-like protein; Region: OsmC; cl00767 593907008068 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 593907008069 Domain of unknown function (DUF427); Region: DUF427; cl00998 593907008070 Domain of unknown function (DUF427); Region: DUF427; cl00998 593907008071 putative transposase OrfB; Reviewed; Region: PHA02517 593907008072 Integrase core domain; Region: rve; cl01316 593907008073 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 593907008074 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 593907008075 Integrase core domain; Region: rve; cl01316 593907008076 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 593907008077 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 593907008078 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 593907008079 Walker A/P-loop; other site 593907008080 ATP binding site [chemical binding]; other site 593907008081 Q-loop/lid; other site 593907008082 ABC transporter signature motif; other site 593907008083 Walker B; other site 593907008084 D-loop; other site 593907008085 H-loop/switch region; other site 593907008086 replicative DNA helicase; Validated; Region: PRK07773 593907008087 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 593907008088 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 593907008089 Walker A motif; other site 593907008090 ATP binding site [chemical binding]; other site 593907008091 Walker B motif; other site 593907008092 DNA binding loops [nucleotide binding] 593907008093 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 593907008094 thioester formation/cholesterol transfer; other site 593907008095 protein-splicing catalytic site; other site 593907008096 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl09966 593907008097 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 593907008098 MatE; Region: MatE; pfam01554 593907008099 MatE; Region: MatE; pfam01554 593907008100 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 593907008101 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 593907008102 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 593907008103 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 593907008104 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 593907008105 dimer interface [polypeptide binding]; other site 593907008106 ssDNA binding site [nucleotide binding]; other site 593907008107 tetramer (dimer of dimers) interface [polypeptide binding]; other site 593907008108 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 593907008109 Transglycosylase; Region: Transgly; cl07896 593907008110 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 593907008111 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 593907008112 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 593907008113 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 593907008114 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 593907008115 Myo-inositol-1-phosphate synthase; Region: Inos-1-P_synth; cl00554 593907008116 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 593907008117 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 593907008118 active site 593907008119 NTP binding site [chemical binding]; other site 593907008120 metal binding triad [ion binding]; metal-binding site 593907008121 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 593907008122 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 593907008123 Zn2+ binding site [ion binding]; other site 593907008124 Mg2+ binding site [ion binding]; other site 593907008125 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 593907008126 active site 593907008127 Ap6A binding site [chemical binding]; other site 593907008128 nudix motif; other site 593907008129 metal binding site [ion binding]; metal-binding site 593907008130 MviN-like protein; Region: MVIN; pfam03023 593907008131 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 593907008132 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 593907008133 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 593907008134 catalytic residues [active] 593907008135 aspartate aminotransferase; Provisional; Region: PRK08361 593907008136 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 593907008137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 593907008138 homodimer interface [polypeptide binding]; other site 593907008139 catalytic residue [active] 593907008140 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 593907008141 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 593907008142 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 593907008143 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 593907008144 ParB-like nuclease domain; Region: ParBc; cl02129 593907008145 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 593907008146 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 593907008147 P-loop; other site 593907008148 Magnesium ion binding site [ion binding]; other site 593907008149 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 593907008150 Magnesium ion binding site [ion binding]; other site 593907008151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 593907008152 hypothetical protein; Provisional; Region: PRK13679 593907008153 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 593907008154 G-X-X-G motif; other site 593907008155 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 593907008156 RxxxH motif; other site 593907008157 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 593907008158 Domain of unknown function DUF37; Region: DUF37; cl00506 593907008159 Ribonuclease P; Region: Ribonuclease_P; cl00457