-- dump date 20140619_030813 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1173020000001 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1173020000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020000003 Walker A motif; other site 1173020000004 ATP binding site [chemical binding]; other site 1173020000005 Walker B motif; other site 1173020000006 arginine finger; other site 1173020000007 Peptidase family M41; Region: Peptidase_M41; pfam01434 1173020000008 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1173020000009 active site 1173020000010 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952 1173020000011 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1173020000012 dimer interface [polypeptide binding]; other site 1173020000013 active site 1173020000014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173020000015 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1173020000016 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1173020000017 Walker A/P-loop; other site 1173020000018 ATP binding site [chemical binding]; other site 1173020000019 Q-loop/lid; other site 1173020000020 ABC transporter signature motif; other site 1173020000021 Walker B; other site 1173020000022 D-loop; other site 1173020000023 H-loop/switch region; other site 1173020000024 TOBE-like domain; Region: TOBE_3; pfam12857 1173020000025 Rrf2 family protein; Region: rrf2_super; TIGR00738 1173020000026 Transcriptional regulator; Region: Rrf2; pfam02082 1173020000027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020000028 dimer interface [polypeptide binding]; other site 1173020000029 conserved gate region; other site 1173020000030 putative PBP binding loops; other site 1173020000031 ABC-ATPase subunit interface; other site 1173020000032 sulfate transport protein; Provisional; Region: cysT; CHL00187 1173020000033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020000034 dimer interface [polypeptide binding]; other site 1173020000035 conserved gate region; other site 1173020000036 putative PBP binding loops; other site 1173020000037 ABC-ATPase subunit interface; other site 1173020000038 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1173020000039 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173020000040 ligand binding site [chemical binding]; other site 1173020000041 flexible hinge region; other site 1173020000042 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173020000043 putative switch regulator; other site 1173020000044 non-specific DNA interactions [nucleotide binding]; other site 1173020000045 DNA binding site [nucleotide binding] 1173020000046 sequence specific DNA binding site [nucleotide binding]; other site 1173020000047 putative cAMP binding site [chemical binding]; other site 1173020000048 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1173020000049 putative active site pocket [active] 1173020000050 dimerization interface [polypeptide binding]; other site 1173020000051 putative catalytic residue [active] 1173020000052 NIL domain; Region: NIL; pfam09383 1173020000053 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1173020000054 serine O-acetyltransferase; Region: cysE; TIGR01172 1173020000055 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1173020000056 trimer interface [polypeptide binding]; other site 1173020000057 active site 1173020000058 substrate binding site [chemical binding]; other site 1173020000059 CoA binding site [chemical binding]; other site 1173020000060 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020000061 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020000062 GAF domain; Region: GAF; pfam01590 1173020000063 GAF domain; Region: GAF_3; pfam13492 1173020000064 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020000065 GAF domain; Region: GAF; pfam01590 1173020000066 PAS fold; Region: PAS_3; pfam08447 1173020000067 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020000068 heme pocket [chemical binding]; other site 1173020000069 putative active site [active] 1173020000070 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020000071 PAS fold; Region: PAS_3; pfam08447 1173020000072 putative active site [active] 1173020000073 heme pocket [chemical binding]; other site 1173020000074 PAS fold; Region: PAS_4; pfam08448 1173020000075 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173020000076 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020000077 putative active site [active] 1173020000078 heme pocket [chemical binding]; other site 1173020000079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020000080 dimer interface [polypeptide binding]; other site 1173020000081 phosphorylation site [posttranslational modification] 1173020000082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020000083 ATP binding site [chemical binding]; other site 1173020000084 Mg2+ binding site [ion binding]; other site 1173020000085 G-X-G motif; other site 1173020000086 Photosystem II reaction centre I protein (PSII 4.8 kDa protein); Region: PsbI; cl03640 1173020000087 OstA-like protein; Region: OstA; cl00844 1173020000088 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 1173020000089 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 1173020000090 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020000091 active site 1173020000092 ATP binding site [chemical binding]; other site 1173020000093 substrate binding site [chemical binding]; other site 1173020000094 activation loop (A-loop); other site 1173020000095 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1173020000096 putative dimer interface [polypeptide binding]; other site 1173020000097 active site pocket [active] 1173020000098 putative cataytic base [active] 1173020000099 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020000100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020000101 active site 1173020000102 phosphorylation site [posttranslational modification] 1173020000103 intermolecular recognition site; other site 1173020000104 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020000105 PAS fold; Region: PAS_3; pfam08447 1173020000106 putative active site [active] 1173020000107 heme pocket [chemical binding]; other site 1173020000108 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020000109 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020000110 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020000111 dimer interface [polypeptide binding]; other site 1173020000112 phosphorylation site [posttranslational modification] 1173020000113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020000114 ATP binding site [chemical binding]; other site 1173020000115 Mg2+ binding site [ion binding]; other site 1173020000116 G-X-G motif; other site 1173020000117 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020000118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020000119 active site 1173020000120 phosphorylation site [posttranslational modification] 1173020000121 intermolecular recognition site; other site 1173020000122 dimerization interface [polypeptide binding]; other site 1173020000123 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020000124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020000125 active site 1173020000126 phosphorylation site [posttranslational modification] 1173020000127 intermolecular recognition site; other site 1173020000128 dimerization interface [polypeptide binding]; other site 1173020000129 FtsH Extracellular; Region: FtsH_ext; pfam06480 1173020000130 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1173020000131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020000132 Walker A motif; other site 1173020000133 ATP binding site [chemical binding]; other site 1173020000134 Walker B motif; other site 1173020000135 arginine finger; other site 1173020000136 Peptidase family M41; Region: Peptidase_M41; pfam01434 1173020000137 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020000138 putative active site [active] 1173020000139 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 1173020000140 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1173020000141 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1173020000142 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1173020000143 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1173020000144 Predicted membrane protein [Function unknown]; Region: COG3431 1173020000145 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1173020000146 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1173020000147 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1173020000148 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1173020000149 Protein chain release factor A [Translation, ribosomal structure and biogenesis]; Region: PrfA; COG0216 1173020000150 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 1173020000151 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1173020000152 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1173020000153 substrate binding site [chemical binding]; other site 1173020000154 active site 1173020000155 conserved hypothetical protein; Region: TIGR02231 1173020000156 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 1173020000157 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1173020000158 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1173020000159 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020000160 GAF domain; Region: GAF; pfam01590 1173020000161 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1173020000162 Zn2+ binding site [ion binding]; other site 1173020000163 Mg2+ binding site [ion binding]; other site 1173020000164 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1173020000165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020000166 S-adenosylmethionine binding site [chemical binding]; other site 1173020000167 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1173020000168 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173020000169 ATP binding site [chemical binding]; other site 1173020000170 putative Mg++ binding site [ion binding]; other site 1173020000171 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173020000172 nucleotide binding region [chemical binding]; other site 1173020000173 ATP-binding site [chemical binding]; other site 1173020000174 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 1173020000175 Integrase core domain; Region: rve; pfam00665 1173020000176 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1173020000177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020000178 AAA domain; Region: AAA_22; pfam13401 1173020000179 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173020000180 Walker A motif; other site 1173020000181 Walker A motif; other site 1173020000182 ATP binding site [chemical binding]; other site 1173020000183 ATP binding site [chemical binding]; other site 1173020000184 Walker B motif; other site 1173020000185 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1173020000186 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1173020000187 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1173020000188 Ligand Binding Site [chemical binding]; other site 1173020000189 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1173020000190 Domain of unknown function DUF21; Region: DUF21; pfam01595 1173020000191 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1173020000192 Transporter associated domain; Region: CorC_HlyC; smart01091 1173020000193 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1173020000194 threonine synthase; Reviewed; Region: PRK06721 1173020000195 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1173020000196 homodimer interface [polypeptide binding]; other site 1173020000197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020000198 catalytic residue [active] 1173020000199 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 1173020000200 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173020000201 active site 1173020000202 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1173020000203 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173020000204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020000205 TPR motif; other site 1173020000206 TPR repeat; Region: TPR_11; pfam13414 1173020000207 binding surface 1173020000208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020000209 binding surface 1173020000210 TPR repeat; Region: TPR_11; pfam13414 1173020000211 TPR motif; other site 1173020000212 TPR repeat; Region: TPR_11; pfam13414 1173020000213 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173020000214 Pirin-related protein [General function prediction only]; Region: COG1741 1173020000215 Pirin; Region: Pirin; pfam02678 1173020000216 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1173020000217 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173020000218 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1173020000219 putative effector binding pocket; other site 1173020000220 dimerization interface [polypeptide binding]; other site 1173020000221 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173020000222 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173020000223 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020000224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020000225 active site 1173020000226 phosphorylation site [posttranslational modification] 1173020000227 intermolecular recognition site; other site 1173020000228 dimerization interface [polypeptide binding]; other site 1173020000229 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020000230 DNA binding site [nucleotide binding] 1173020000231 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1173020000232 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 1173020000233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020000234 ATP binding site [chemical binding]; other site 1173020000235 Mg2+ binding site [ion binding]; other site 1173020000236 G-X-G motif; other site 1173020000237 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1173020000238 ATP binding site [chemical binding]; other site 1173020000239 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1173020000240 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1173020000241 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1173020000242 Walker A/P-loop; other site 1173020000243 ATP binding site [chemical binding]; other site 1173020000244 Q-loop/lid; other site 1173020000245 ABC transporter signature motif; other site 1173020000246 Walker B; other site 1173020000247 D-loop; other site 1173020000248 H-loop/switch region; other site 1173020000249 TOBE-like domain; Region: TOBE_3; pfam12857 1173020000250 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 1173020000251 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1173020000252 dimer interface [polypeptide binding]; other site 1173020000253 active site 1173020000254 CoA binding pocket [chemical binding]; other site 1173020000255 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173020000256 active site 1173020000257 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 1173020000258 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173020000259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173020000260 NAD(P) binding site [chemical binding]; other site 1173020000261 active site 1173020000262 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1173020000263 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 1173020000264 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1173020000265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020000266 Walker A motif; other site 1173020000267 ATP binding site [chemical binding]; other site 1173020000268 Walker B motif; other site 1173020000269 arginine finger; other site 1173020000270 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 1173020000271 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 1173020000272 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1173020000273 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1173020000274 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1173020000275 TPP-binding site; other site 1173020000276 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1173020000277 PYR/PP interface [polypeptide binding]; other site 1173020000278 dimer interface [polypeptide binding]; other site 1173020000279 TPP binding site [chemical binding]; other site 1173020000280 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1173020000281 Rhomboid family; Region: Rhomboid; pfam01694 1173020000282 Uncharacterized conserved protein [Function unknown]; Region: COG3937 1173020000283 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1173020000284 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1173020000285 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1173020000286 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173020000287 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173020000288 DNA binding residues [nucleotide binding] 1173020000289 Putative zinc-finger; Region: zf-HC2; pfam13490 1173020000290 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1173020000291 catalytic triad [active] 1173020000292 Phytochelatin synthase; Region: Phytochelatin; pfam05023 1173020000293 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1173020000294 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173020000295 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1173020000296 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1173020000297 RNA methyltransferase, RsmE family; Region: TIGR00046 1173020000298 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173020000299 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1173020000300 HSP70 interaction site [polypeptide binding]; other site 1173020000301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173020000302 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020000303 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173020000304 active site 1173020000305 ATP binding site [chemical binding]; other site 1173020000306 substrate binding site [chemical binding]; other site 1173020000307 activation loop (A-loop); other site 1173020000308 PBP superfamily domain; Region: PBP_like_2; cl17296 1173020000309 ParB-like nuclease domain; Region: ParBc; pfam02195 1173020000310 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1173020000311 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173020000312 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173020000313 P-loop; other site 1173020000314 Magnesium ion binding site [ion binding]; other site 1173020000315 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173020000316 Magnesium ion binding site [ion binding]; other site 1173020000317 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1173020000318 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1173020000319 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020000320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020000321 active site 1173020000322 phosphorylation site [posttranslational modification] 1173020000323 intermolecular recognition site; other site 1173020000324 dimerization interface [polypeptide binding]; other site 1173020000325 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1173020000326 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1173020000327 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1173020000328 hexamer interface [polypeptide binding]; other site 1173020000329 ligand binding site [chemical binding]; other site 1173020000330 putative active site [active] 1173020000331 NAD(P) binding site [chemical binding]; other site 1173020000332 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1173020000333 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173020000334 active site 1173020000335 metal binding site [ion binding]; metal-binding site 1173020000336 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173020000337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173020000338 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173020000339 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173020000340 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1173020000341 FtsX-like permease family; Region: FtsX; pfam02687 1173020000342 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1173020000343 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1173020000344 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1173020000345 Walker A/P-loop; other site 1173020000346 ATP binding site [chemical binding]; other site 1173020000347 Q-loop/lid; other site 1173020000348 ABC transporter signature motif; other site 1173020000349 Walker B; other site 1173020000350 D-loop; other site 1173020000351 H-loop/switch region; other site 1173020000352 Protein of unknown function, DUF479; Region: DUF479; cl01203 1173020000353 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173020000354 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173020000355 active site 1173020000356 catalytic tetrad [active] 1173020000357 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020000358 putative active site [active] 1173020000359 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020000360 putative active site [active] 1173020000361 excinuclease ABC subunit B; Provisional; Region: PRK05298 1173020000362 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173020000363 ATP binding site [chemical binding]; other site 1173020000364 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173020000365 nucleotide binding region [chemical binding]; other site 1173020000366 ATP-binding site [chemical binding]; other site 1173020000367 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1173020000368 UvrB/uvrC motif; Region: UVR; pfam02151 1173020000369 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 1173020000370 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1173020000371 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 1173020000372 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1173020000373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173020000374 NAD(P) binding site [chemical binding]; other site 1173020000375 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 1173020000376 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173020000377 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020000378 Coenzyme A binding pocket [chemical binding]; other site 1173020000379 Predicted nucleotidyltransferase [General function prediction only]; Region: COG3541 1173020000380 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 1173020000381 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1173020000382 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173020000383 active site 1173020000384 aspartate aminotransferase; Provisional; Region: PRK05764 1173020000385 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173020000386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020000387 homodimer interface [polypeptide binding]; other site 1173020000388 catalytic residue [active] 1173020000389 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020000390 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173020000391 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1173020000392 metal ion-dependent adhesion site (MIDAS); other site 1173020000393 Tubulin like; Region: Tubulin_2; pfam13809 1173020000394 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1173020000395 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1173020000396 ligand binding site [chemical binding]; other site 1173020000397 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1173020000398 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1173020000399 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1173020000400 Transposase IS200 like; Region: Y1_Tnp; cl00848 1173020000401 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1173020000402 MgtE intracellular N domain; Region: MgtE_N; smart00924 1173020000403 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1173020000404 Divalent cation transporter; Region: MgtE; pfam01769 1173020000405 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1173020000406 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1173020000407 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1173020000408 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1173020000409 Walker A/P-loop; other site 1173020000410 ATP binding site [chemical binding]; other site 1173020000411 Q-loop/lid; other site 1173020000412 ABC transporter signature motif; other site 1173020000413 Walker B; other site 1173020000414 D-loop; other site 1173020000415 H-loop/switch region; other site 1173020000416 H+ Antiporter protein; Region: 2A0121; TIGR00900 1173020000417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020000418 putative substrate translocation pore; other site 1173020000419 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1173020000420 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1173020000421 FtsX-like permease family; Region: FtsX; pfam02687 1173020000422 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1173020000423 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1173020000424 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173020000425 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020000426 binding surface 1173020000427 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173020000428 TPR motif; other site 1173020000429 TPR repeat; Region: TPR_11; pfam13414 1173020000430 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020000431 binding surface 1173020000432 TPR motif; other site 1173020000433 TPR repeat; Region: TPR_11; pfam13414 1173020000434 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020000435 binding surface 1173020000436 TPR repeat; Region: TPR_11; pfam13414 1173020000437 TPR motif; other site 1173020000438 DNA gyrase subunit A; Validated; Region: PRK05560 1173020000439 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1173020000440 CAP-like domain; other site 1173020000441 active site 1173020000442 primary dimer interface [polypeptide binding]; other site 1173020000443 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173020000444 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173020000445 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173020000446 hypothetical protein; Validated; Region: PRK00110 1173020000447 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173020000448 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1173020000449 Walker A/P-loop; other site 1173020000450 ATP binding site [chemical binding]; other site 1173020000451 Q-loop/lid; other site 1173020000452 ABC transporter signature motif; other site 1173020000453 Walker B; other site 1173020000454 D-loop; other site 1173020000455 H-loop/switch region; other site 1173020000456 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1173020000457 alpha-gamma subunit interface [polypeptide binding]; other site 1173020000458 beta-gamma subunit interface [polypeptide binding]; other site 1173020000459 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1173020000460 photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042 1173020000461 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1173020000462 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1173020000463 active site 1173020000464 catalytic motif [active] 1173020000465 Zn binding site [ion binding]; other site 1173020000466 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364 1173020000467 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1173020000468 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1173020000469 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173020000470 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1173020000471 catalytic triad [active] 1173020000472 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1173020000473 active site 1173020000474 Zn binding site [ion binding]; other site 1173020000475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 1173020000476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020000477 AAA domain; Region: AAA_23; pfam13476 1173020000478 Walker A/P-loop; other site 1173020000479 ATP binding site [chemical binding]; other site 1173020000480 Q-loop/lid; other site 1173020000481 exonuclease SbcC; Region: sbcc; TIGR00618 1173020000482 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1173020000483 ABC transporter signature motif; other site 1173020000484 Walker B; other site 1173020000485 D-loop; other site 1173020000486 H-loop/switch region; other site 1173020000487 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1173020000488 active site 1173020000489 SAM binding site [chemical binding]; other site 1173020000490 homodimer interface [polypeptide binding]; other site 1173020000491 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1173020000492 DNA binding site [nucleotide binding] 1173020000493 active site 1173020000494 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 1173020000495 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1173020000496 NAD binding site [chemical binding]; other site 1173020000497 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173020000498 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1173020000499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020000500 S-adenosylmethionine binding site [chemical binding]; other site 1173020000501 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 1173020000502 Rrf2 family protein; Region: rrf2_super; TIGR00738 1173020000503 Transcriptional regulator; Region: Rrf2; cl17282 1173020000504 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 1173020000505 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1173020000506 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173020000507 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173020000508 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173020000509 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173020000510 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173020000511 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173020000512 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173020000513 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173020000514 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 1173020000515 CHAT domain; Region: CHAT; cl17868 1173020000516 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1173020000517 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1173020000518 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 1173020000519 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 1173020000520 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1173020000521 iron-sulfur cluster [ion binding]; other site 1173020000522 [2Fe-2S] cluster binding site [ion binding]; other site 1173020000523 cytochrome f; Region: petA; CHL00037 1173020000524 apocytochrome f; Reviewed; Region: PRK02693 1173020000525 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1173020000526 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1173020000527 Ligand Binding Site [chemical binding]; other site 1173020000528 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 1173020000529 Circadian oscillating protein COP23; Region: COP23; pfam14218 1173020000530 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1173020000531 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1173020000532 catalytic triad [active] 1173020000533 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1173020000534 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1173020000535 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1173020000536 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1173020000537 putative active site [active] 1173020000538 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1173020000539 ATP-grasp domain; Region: ATP-grasp; pfam02222 1173020000540 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173020000541 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173020000542 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1173020000543 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1173020000544 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1173020000545 homopentamer interface [polypeptide binding]; other site 1173020000546 active site 1173020000547 photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576 1173020000548 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1173020000549 putative ADP-ribose binding site [chemical binding]; other site 1173020000550 putative active site [active] 1173020000551 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1173020000552 DHH family; Region: DHH; pfam01368 1173020000553 DHHA1 domain; Region: DHHA1; pfam02272 1173020000554 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173020000555 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020000556 Coenzyme A binding pocket [chemical binding]; other site 1173020000557 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1173020000558 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020000559 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020000560 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020000561 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020000562 Nuclease A inhibitor-like protein; Region: NuiA; pfam07924 1173020000563 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1173020000564 oligomeric interface; other site 1173020000565 putative active site [active] 1173020000566 homodimer interface [polypeptide binding]; other site 1173020000567 Protein of unknown function DUF104; Region: DUF104; cl11530 1173020000568 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1173020000569 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1173020000570 Zn binding site [ion binding]; other site 1173020000571 Protein of unknown function (DUF433); Region: DUF433; cl01030 1173020000572 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1173020000573 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1173020000574 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173020000575 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020000576 putative active site [active] 1173020000577 FO synthase subunit 2; Reviewed; Region: PRK07360 1173020000578 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173020000579 FeS/SAM binding site; other site 1173020000580 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 1173020000581 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1173020000582 P loop; other site 1173020000583 Nucleotide binding site [chemical binding]; other site 1173020000584 DTAP/Switch II; other site 1173020000585 Switch I; other site 1173020000586 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1173020000587 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1173020000588 catalytic residue [active] 1173020000589 putative FPP diphosphate binding site; other site 1173020000590 putative FPP binding hydrophobic cleft; other site 1173020000591 dimer interface [polypeptide binding]; other site 1173020000592 putative IPP diphosphate binding site; other site 1173020000593 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1173020000594 dinuclear metal binding motif [ion binding]; other site 1173020000595 NACHT domain; Region: NACHT; pfam05729 1173020000596 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173020000597 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 1173020000598 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1173020000599 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 1173020000600 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1173020000601 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1173020000602 putative ABC transporter; Region: ycf24; CHL00085 1173020000603 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020000604 putative active site [active] 1173020000605 Protein of unknown function (DUF433); Region: DUF433; pfam04255 1173020000606 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 1173020000607 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1173020000608 Walker A/P-loop; other site 1173020000609 ATP binding site [chemical binding]; other site 1173020000610 Q-loop/lid; other site 1173020000611 ABC transporter signature motif; other site 1173020000612 Walker B; other site 1173020000613 D-loop; other site 1173020000614 H-loop/switch region; other site 1173020000615 FeS assembly protein SufD; Region: sufD; TIGR01981 1173020000616 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1173020000617 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1173020000618 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1173020000619 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173020000620 catalytic residue [active] 1173020000621 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1173020000622 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1173020000623 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1173020000624 SelR domain; Region: SelR; pfam01641 1173020000625 FOG: CBS domain [General function prediction only]; Region: COG0517 1173020000626 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 1173020000627 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173020000628 PemK-like protein; Region: PemK; pfam02452 1173020000629 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1173020000630 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1173020000631 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020000632 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173020000633 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020000634 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1173020000635 RNA ligase; Region: RNA_ligase; pfam09414 1173020000636 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1173020000637 Zn2+ binding site [ion binding]; other site 1173020000638 Mg2+ binding site [ion binding]; other site 1173020000639 AAA domain; Region: AAA_33; pfam13671 1173020000640 Protein of unknown function (DUF504); Region: DUF504; pfam04457 1173020000641 Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains; Region: TDP2; cd09080 1173020000642 putative catalytic site [active] 1173020000643 putative metal binding site [ion binding]; other site 1173020000644 putative phosphate binding site [ion binding]; other site 1173020000645 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1173020000646 Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Region: NT_PAP_TUTase; cd05402 1173020000647 active site 1173020000648 putative primer-binding pocket; other site 1173020000649 Poly(A) polymerase central domain; Region: PAP_central; pfam04928 1173020000650 metal binding triad [ion binding]; metal-binding site 1173020000651 HEAT repeats; Region: HEAT_2; pfam13646 1173020000652 HEAT repeats; Region: HEAT_2; pfam13646 1173020000653 HEAT repeats; Region: HEAT_2; pfam13646 1173020000654 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 1173020000655 HEAT repeats; Region: HEAT_2; pfam13646 1173020000656 protein binding surface [polypeptide binding]; other site 1173020000657 HEAT repeats; Region: HEAT_2; pfam13646 1173020000658 dihydroorotase; Provisional; Region: PRK07369 1173020000659 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1173020000660 active site 1173020000661 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173020000662 catalytic core [active] 1173020000663 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173020000664 catalytic core [active] 1173020000665 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020000666 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020000667 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020000668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020000669 dimer interface [polypeptide binding]; other site 1173020000670 phosphorylation site [posttranslational modification] 1173020000671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020000672 ATP binding site [chemical binding]; other site 1173020000673 Mg2+ binding site [ion binding]; other site 1173020000674 G-X-G motif; other site 1173020000675 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1173020000676 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020000677 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020000678 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020000679 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1173020000680 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1173020000681 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1173020000682 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1173020000683 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1173020000684 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173020000685 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1173020000686 IMP binding site; other site 1173020000687 dimer interface [polypeptide binding]; other site 1173020000688 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1173020000689 catalytic residues [active] 1173020000690 dimer interface [polypeptide binding]; other site 1173020000691 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1173020000692 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1173020000693 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1173020000694 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1173020000695 ring oligomerisation interface [polypeptide binding]; other site 1173020000696 ATP/Mg binding site [chemical binding]; other site 1173020000697 stacking interactions; other site 1173020000698 hinge regions; other site 1173020000699 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1173020000700 oligomerisation interface [polypeptide binding]; other site 1173020000701 mobile loop; other site 1173020000702 roof hairpin; other site 1173020000703 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1173020000704 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1173020000705 DNA-binding site [nucleotide binding]; DNA binding site 1173020000706 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1173020000707 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 1173020000708 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1173020000709 putative di-iron ligands [ion binding]; other site 1173020000710 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1173020000711 hypothetical protein; Validated; Region: PRK07581 1173020000712 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 1173020000713 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1173020000714 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1173020000715 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1173020000716 active site 1173020000717 dimer interface [polypeptide binding]; other site 1173020000718 PsaD; Region: PsaD; pfam02531 1173020000719 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1173020000720 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1173020000721 putative active site [active] 1173020000722 metal binding site [ion binding]; metal-binding site 1173020000723 S-layer homology domain; Region: SLH; pfam00395 1173020000724 cell division protein FtsZ; Validated; Region: PRK09330 1173020000725 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1173020000726 nucleotide binding site [chemical binding]; other site 1173020000727 SulA interaction site; other site 1173020000728 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1173020000729 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1173020000730 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1173020000731 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1173020000732 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1173020000733 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1173020000734 LabA_like proteins; Region: LabA; cd10911 1173020000735 putative metal binding site [ion binding]; other site 1173020000736 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1173020000737 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1173020000738 active site 1173020000739 HIGH motif; other site 1173020000740 KMSKS motif; other site 1173020000741 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1173020000742 tRNA binding surface [nucleotide binding]; other site 1173020000743 anticodon binding site; other site 1173020000744 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1173020000745 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020000746 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 1173020000747 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 1173020000748 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1173020000749 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 1173020000750 putative di-iron ligands [ion binding]; other site 1173020000751 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1173020000752 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1173020000753 hinge; other site 1173020000754 active site 1173020000755 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1173020000756 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1173020000757 dimer interface [polypeptide binding]; other site 1173020000758 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1173020000759 catalytic triad [active] 1173020000760 amidophosphoribosyltransferase; Provisional; Region: PRK07349 1173020000761 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1173020000762 active site 1173020000763 tetramer interface [polypeptide binding]; other site 1173020000764 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173020000765 active site 1173020000766 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020000767 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020000768 structural tetrad; other site 1173020000769 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173020000770 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1173020000771 NAD binding site [chemical binding]; other site 1173020000772 putative substrate binding site 2 [chemical binding]; other site 1173020000773 putative substrate binding site 1 [chemical binding]; other site 1173020000774 active site 1173020000775 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1173020000776 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1173020000777 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1173020000778 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1173020000779 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1173020000780 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1173020000781 Chain length determinant protein; Region: Wzz; cl15801 1173020000782 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 1173020000783 Pilus assembly protein, PilO; Region: PilO; cl01234 1173020000784 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1173020000785 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1173020000786 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173020000787 Magnesium ion binding site [ion binding]; other site 1173020000788 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1173020000789 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1173020000790 dimer interface [polypeptide binding]; other site 1173020000791 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1173020000792 catalytic triad [active] 1173020000793 peroxidatic and resolving cysteines [active] 1173020000794 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 1173020000795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020000796 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1173020000797 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1173020000798 active site 1173020000799 interdomain interaction site; other site 1173020000800 putative metal-binding site [ion binding]; other site 1173020000801 nucleotide binding site [chemical binding]; other site 1173020000802 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1173020000803 domain I; other site 1173020000804 phosphate binding site [ion binding]; other site 1173020000805 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1173020000806 domain II; other site 1173020000807 domain III; other site 1173020000808 nucleotide binding site [chemical binding]; other site 1173020000809 DNA binding groove [nucleotide binding] 1173020000810 catalytic site [active] 1173020000811 domain IV; other site 1173020000812 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1173020000813 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1173020000814 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1173020000815 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1173020000816 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173020000817 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1173020000818 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173020000819 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1173020000820 Probable Catalytic site; other site 1173020000821 metal-binding site 1173020000822 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173020000823 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020000824 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173020000825 active site 1173020000826 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173020000827 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173020000828 active site 1173020000829 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1173020000830 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1173020000831 inhibitor-cofactor binding pocket; inhibition site 1173020000832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020000833 catalytic residue [active] 1173020000834 WxcM-like, C-terminal; Region: FdtA; pfam05523 1173020000835 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1173020000836 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1173020000837 putative trimer interface [polypeptide binding]; other site 1173020000838 putative CoA binding site [chemical binding]; other site 1173020000839 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1173020000840 putative trimer interface [polypeptide binding]; other site 1173020000841 putative active site [active] 1173020000842 putative substrate binding site [chemical binding]; other site 1173020000843 putative CoA binding site [chemical binding]; other site 1173020000844 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1173020000845 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1173020000846 Walker A/P-loop; other site 1173020000847 ATP binding site [chemical binding]; other site 1173020000848 Q-loop/lid; other site 1173020000849 ABC transporter signature motif; other site 1173020000850 Walker B; other site 1173020000851 D-loop; other site 1173020000852 H-loop/switch region; other site 1173020000853 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1173020000854 putative carbohydrate binding site [chemical binding]; other site 1173020000855 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1173020000856 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1173020000857 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1173020000858 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1173020000859 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1173020000860 dimer interface [polypeptide binding]; other site 1173020000861 catalytic residues [active] 1173020000862 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 1173020000863 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1173020000864 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1173020000865 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1173020000866 putative di-iron ligands [ion binding]; other site 1173020000867 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 1173020000868 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1173020000869 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173020000870 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020000871 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1173020000872 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173020000873 ATP binding site [chemical binding]; other site 1173020000874 putative Mg++ binding site [ion binding]; other site 1173020000875 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173020000876 nucleotide binding region [chemical binding]; other site 1173020000877 ATP-binding site [chemical binding]; other site 1173020000878 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1173020000879 homotrimer interaction site [polypeptide binding]; other site 1173020000880 putative active site [active] 1173020000881 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1173020000882 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1173020000883 Ligand binding site; other site 1173020000884 Putative Catalytic site; other site 1173020000885 DXD motif; other site 1173020000886 YCII-related domain; Region: YCII; cl00999 1173020000887 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020000888 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1173020000889 Lumazine binding domain; Region: Lum_binding; pfam00677 1173020000890 Lumazine binding domain; Region: Lum_binding; pfam00677 1173020000891 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1173020000892 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1173020000893 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1173020000894 dimer interface [polypeptide binding]; other site 1173020000895 active site 1173020000896 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1173020000897 folate binding site [chemical binding]; other site 1173020000898 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173020000899 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1173020000900 ligand binding site [chemical binding]; other site 1173020000901 flexible hinge region; other site 1173020000902 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173020000903 putative switch regulator; other site 1173020000904 non-specific DNA interactions [nucleotide binding]; other site 1173020000905 DNA binding site [nucleotide binding] 1173020000906 sequence specific DNA binding site [nucleotide binding]; other site 1173020000907 putative cAMP binding site [chemical binding]; other site 1173020000908 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 1173020000909 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1173020000910 NAD binding site [chemical binding]; other site 1173020000911 homotetramer interface [polypeptide binding]; other site 1173020000912 homodimer interface [polypeptide binding]; other site 1173020000913 substrate binding site [chemical binding]; other site 1173020000914 active site 1173020000915 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1173020000916 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1173020000917 lipoprotein signal peptidase; Provisional; Region: PRK14787 1173020000918 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1173020000919 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 1173020000920 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1173020000921 TPR repeat; Region: TPR_11; pfam13414 1173020000922 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020000923 binding surface 1173020000924 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173020000925 TPR motif; other site 1173020000926 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173020000927 comF family protein; Region: comF; TIGR00201 1173020000928 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173020000929 active site 1173020000930 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1173020000931 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1173020000932 putative methyltransferase, LIC12133 family; Region: MTase_LIC12133; TIGR04325 1173020000933 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1173020000934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020000935 S-adenosylmethionine binding site [chemical binding]; other site 1173020000936 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020000937 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1173020000938 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1173020000939 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1173020000940 active site 1173020000941 HIGH motif; other site 1173020000942 dimer interface [polypeptide binding]; other site 1173020000943 KMSKS motif; other site 1173020000944 Transglycosylase; Region: Transgly; pfam00912 1173020000945 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1173020000946 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1173020000947 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1173020000948 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173020000949 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1173020000950 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020000951 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020000952 structural tetrad; other site 1173020000953 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1173020000954 structural tetrad; other site 1173020000955 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020000956 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1173020000957 Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909 1173020000958 active site 1173020000959 Zn binding site [ion binding]; other site 1173020000960 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1173020000961 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1173020000962 putative NAD(P) binding site [chemical binding]; other site 1173020000963 putative substrate binding site [chemical binding]; other site 1173020000964 catalytic Zn binding site [ion binding]; other site 1173020000965 structural Zn binding site [ion binding]; other site 1173020000966 dimer interface [polypeptide binding]; other site 1173020000967 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 1173020000968 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1173020000969 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1173020000970 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1173020000971 active site 1173020000972 SAM binding site [chemical binding]; other site 1173020000973 homodimer interface [polypeptide binding]; other site 1173020000974 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1173020000975 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 1173020000976 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 1173020000977 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1173020000978 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1173020000979 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173020000980 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020000981 active site 1173020000982 ATP binding site [chemical binding]; other site 1173020000983 substrate binding site [chemical binding]; other site 1173020000984 activation loop (A-loop); other site 1173020000985 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 1173020000986 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173020000987 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173020000988 phosphopeptide binding site; other site 1173020000989 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173020000990 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173020000991 phosphopeptide binding site; other site 1173020000992 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1173020000993 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1173020000994 Walker A/P-loop; other site 1173020000995 ATP binding site [chemical binding]; other site 1173020000996 Q-loop/lid; other site 1173020000997 ABC transporter signature motif; other site 1173020000998 Walker B; other site 1173020000999 D-loop; other site 1173020001000 H-loop/switch region; other site 1173020001001 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1173020001002 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1173020001003 adaptive-response sensory kinase; Validated; Region: PRK09303 1173020001004 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1173020001005 tetramer interface [polypeptide binding]; other site 1173020001006 dimer interface [polypeptide binding]; other site 1173020001007 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1173020001008 dimer interface [polypeptide binding]; other site 1173020001009 phosphorylation site [posttranslational modification] 1173020001010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020001011 ATP binding site [chemical binding]; other site 1173020001012 Mg2+ binding site [ion binding]; other site 1173020001013 G-X-G motif; other site 1173020001014 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1173020001015 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 1173020001016 active site 1173020001017 substrate binding site [chemical binding]; other site 1173020001018 catalytic site [active] 1173020001019 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1173020001020 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173020001021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020001022 S-adenosylmethionine binding site [chemical binding]; other site 1173020001023 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1173020001024 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1173020001025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020001026 dimer interface [polypeptide binding]; other site 1173020001027 conserved gate region; other site 1173020001028 putative PBP binding loops; other site 1173020001029 ABC-ATPase subunit interface; other site 1173020001030 HEAT repeats; Region: HEAT_2; pfam13646 1173020001031 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020001032 putative active site [active] 1173020001033 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1173020001034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020001035 dimer interface [polypeptide binding]; other site 1173020001036 conserved gate region; other site 1173020001037 putative PBP binding loops; other site 1173020001038 ABC-ATPase subunit interface; other site 1173020001039 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1173020001040 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1173020001041 Walker A/P-loop; other site 1173020001042 ATP binding site [chemical binding]; other site 1173020001043 Q-loop/lid; other site 1173020001044 ABC transporter signature motif; other site 1173020001045 Walker B; other site 1173020001046 D-loop; other site 1173020001047 H-loop/switch region; other site 1173020001048 signal recognition particle protein; Provisional; Region: PRK10867 1173020001049 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1173020001050 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1173020001051 P loop; other site 1173020001052 GTP binding site [chemical binding]; other site 1173020001053 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1173020001054 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173020001055 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173020001056 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 1173020001057 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1173020001058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020001059 mercuric reductase; Validated; Region: PRK06370 1173020001060 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173020001061 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1173020001062 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1173020001063 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1173020001064 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371 1173020001065 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173020001066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020001067 S-adenosylmethionine binding site [chemical binding]; other site 1173020001068 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1173020001069 RibD C-terminal domain; Region: RibD_C; cl17279 1173020001070 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1173020001071 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1173020001072 hydrophobic ligand binding site; other site 1173020001073 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173020001074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020001075 Coenzyme A binding pocket [chemical binding]; other site 1173020001076 AAA ATPase domain; Region: AAA_16; pfam13191 1173020001077 NACHT domain; Region: NACHT; pfam05729 1173020001078 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020001079 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020001080 structural tetrad; other site 1173020001081 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020001082 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020001083 structural tetrad; other site 1173020001084 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020001085 structural tetrad; other site 1173020001086 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 1173020001087 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020001088 TPR repeat; Region: TPR_11; pfam13414 1173020001089 binding surface 1173020001090 TPR motif; other site 1173020001091 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1173020001092 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1173020001093 P-loop, Walker A motif; other site 1173020001094 Base recognition motif; other site 1173020001095 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1173020001096 Tubulin like; Region: Tubulin_2; pfam13809 1173020001097 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 1173020001098 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 1173020001099 multimer interface [polypeptide binding]; other site 1173020001100 active site 1173020001101 catalytic triad [active] 1173020001102 dimer interface [polypeptide binding]; other site 1173020001103 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1173020001104 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020001105 active site 1173020001106 motif I; other site 1173020001107 motif II; other site 1173020001108 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173020001109 NADH dehydrogenase subunit 3; Region: ndhC; CHL00022 1173020001110 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 1173020001111 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1173020001112 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 1173020001113 CpeS-like protein; Region: CpeS; pfam09367 1173020001114 AMIN domain; Region: AMIN; pfam11741 1173020001115 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1173020001116 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1173020001117 Protein kinase domain; Region: Pkinase; pfam00069 1173020001118 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020001119 active site 1173020001120 ATP binding site [chemical binding]; other site 1173020001121 substrate binding site [chemical binding]; other site 1173020001122 activation loop (A-loop); other site 1173020001123 Predicted ATPase [General function prediction only]; Region: COG3899 1173020001124 AAA ATPase domain; Region: AAA_16; pfam13191 1173020001125 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020001126 GAF domain; Region: GAF; pfam01590 1173020001127 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020001128 PAS domain; Region: PAS_9; pfam13426 1173020001129 putative active site [active] 1173020001130 heme pocket [chemical binding]; other site 1173020001131 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173020001132 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020001133 putative active site [active] 1173020001134 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020001135 heme pocket [chemical binding]; other site 1173020001136 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020001137 dimer interface [polypeptide binding]; other site 1173020001138 phosphorylation site [posttranslational modification] 1173020001139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020001140 ATP binding site [chemical binding]; other site 1173020001141 Mg2+ binding site [ion binding]; other site 1173020001142 G-X-G motif; other site 1173020001143 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020001144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020001145 active site 1173020001146 phosphorylation site [posttranslational modification] 1173020001147 intermolecular recognition site; other site 1173020001148 dimerization interface [polypeptide binding]; other site 1173020001149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020001150 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020001151 dimer interface [polypeptide binding]; other site 1173020001152 phosphorylation site [posttranslational modification] 1173020001153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020001154 ATP binding site [chemical binding]; other site 1173020001155 Mg2+ binding site [ion binding]; other site 1173020001156 G-X-G motif; other site 1173020001157 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020001158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020001159 active site 1173020001160 phosphorylation site [posttranslational modification] 1173020001161 intermolecular recognition site; other site 1173020001162 dimerization interface [polypeptide binding]; other site 1173020001163 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1173020001164 dimer interface [polypeptide binding]; other site 1173020001165 [2Fe-2S] cluster binding site [ion binding]; other site 1173020001166 Protein of unknown function (DUF952); Region: DUF952; cl01393 1173020001167 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1173020001168 putative catalytic site [active] 1173020001169 putative phosphate binding site [ion binding]; other site 1173020001170 active site 1173020001171 metal binding site A [ion binding]; metal-binding site 1173020001172 DNA binding site [nucleotide binding] 1173020001173 putative AP binding site [nucleotide binding]; other site 1173020001174 putative metal binding site B [ion binding]; other site 1173020001175 TIGR02452 family protein; Region: TIGR02452 1173020001176 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 1173020001177 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1173020001178 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1173020001179 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173020001180 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020001181 Coenzyme A binding pocket [chemical binding]; other site 1173020001182 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1173020001183 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1173020001184 putative active site [active] 1173020001185 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1173020001186 metal binding site 2 [ion binding]; metal-binding site 1173020001187 putative DNA binding helix; other site 1173020001188 metal binding site 1 [ion binding]; metal-binding site 1173020001189 dimer interface [polypeptide binding]; other site 1173020001190 structural Zn2+ binding site [ion binding]; other site 1173020001191 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1173020001192 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1173020001193 catalytic triad [active] 1173020001194 dimer interface [polypeptide binding]; other site 1173020001195 glutathione reductase; Validated; Region: PRK06116 1173020001196 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173020001197 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1173020001198 Photosystem I reaction centre subunit IV / PsaE; Region: PSI_PsaE; pfam02427 1173020001199 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173020001200 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173020001201 active site 1173020001202 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173020001203 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1173020001204 active site 1173020001205 Fic family protein [Function unknown]; Region: COG3177 1173020001206 Fic/DOC family; Region: Fic; pfam02661 1173020001207 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1173020001208 putative DNA binding site [nucleotide binding]; other site 1173020001209 putative Zn2+ binding site [ion binding]; other site 1173020001210 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173020001211 FeS/SAM binding site; other site 1173020001212 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173020001213 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1173020001214 Walker A/P-loop; other site 1173020001215 ATP binding site [chemical binding]; other site 1173020001216 Q-loop/lid; other site 1173020001217 ABC transporter signature motif; other site 1173020001218 Walker B; other site 1173020001219 D-loop; other site 1173020001220 H-loop/switch region; other site 1173020001221 SnoaL-like domain; Region: SnoaL_2; pfam12680 1173020001222 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 1173020001223 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 1173020001224 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1173020001225 classical (c) SDRs; Region: SDR_c; cd05233 1173020001226 NAD(P) binding site [chemical binding]; other site 1173020001227 active site 1173020001228 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173020001229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020001230 Coenzyme A binding pocket [chemical binding]; other site 1173020001231 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173020001232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173020001233 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1173020001234 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1173020001235 cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153 1173020001236 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 1173020001237 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 1173020001238 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 1173020001239 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173020001240 dimer interface [polypeptide binding]; other site 1173020001241 putative metal binding site [ion binding]; other site 1173020001242 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1173020001243 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1173020001244 dimer interface [polypeptide binding]; other site 1173020001245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020001246 catalytic residue [active] 1173020001247 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1173020001248 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1173020001249 homotrimer interaction site [polypeptide binding]; other site 1173020001250 zinc binding site [ion binding]; other site 1173020001251 CDP-binding sites; other site 1173020001252 TPR repeat; Region: TPR_11; pfam13414 1173020001253 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020001254 binding surface 1173020001255 TPR motif; other site 1173020001256 TPR repeat; Region: TPR_11; pfam13414 1173020001257 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020001258 binding surface 1173020001259 TPR motif; other site 1173020001260 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1173020001261 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1173020001262 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173020001263 TrkA-N domain; Region: TrkA_N; pfam02254 1173020001264 TrkA-C domain; Region: TrkA_C; pfam02080 1173020001265 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1173020001266 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1173020001267 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1173020001268 Fasciclin domain; Region: Fasciclin; pfam02469 1173020001269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020001270 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173020001271 Coenzyme A binding pocket [chemical binding]; other site 1173020001272 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 1173020001273 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 1173020001274 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173020001275 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1173020001276 active site clefts [active] 1173020001277 zinc binding site [ion binding]; other site 1173020001278 dimer interface [polypeptide binding]; other site 1173020001279 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 1173020001280 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173020001281 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1173020001282 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173020001283 FCP1-like phosphatase, phosphatase domain; Region: FCP1_euk; TIGR02250 1173020001284 NLI interacting factor-like phosphatase; Region: NIF; pfam03031 1173020001285 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1173020001286 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173020001287 FeS/SAM binding site; other site 1173020001288 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1173020001289 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 1173020001290 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 1173020001291 MOFRL family; Region: MOFRL; pfam05161 1173020001292 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1173020001293 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1173020001294 GatB domain; Region: GatB_Yqey; smart00845 1173020001295 pantothenate kinase; Reviewed; Region: PRK13331 1173020001296 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173020001297 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1173020001298 catalytic site [active] 1173020001299 argininosuccinate lyase; Provisional; Region: PRK00855 1173020001300 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1173020001301 active sites [active] 1173020001302 tetramer interface [polypeptide binding]; other site 1173020001303 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173020001304 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 1173020001305 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 1173020001306 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1173020001307 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1173020001308 substrate binding site [chemical binding]; other site 1173020001309 active site 1173020001310 catalytic residues [active] 1173020001311 heterodimer interface [polypeptide binding]; other site 1173020001312 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1173020001313 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1173020001314 iron-sulfur cluster [ion binding]; other site 1173020001315 [2Fe-2S] cluster binding site [ion binding]; other site 1173020001316 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1173020001317 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1173020001318 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1173020001319 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1173020001320 putative trimer interface [polypeptide binding]; other site 1173020001321 putative CoA binding site [chemical binding]; other site 1173020001322 Protein of unknown function DUF45; Region: DUF45; pfam01863 1173020001323 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 1173020001324 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1173020001325 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173020001326 ATP binding site [chemical binding]; other site 1173020001327 putative Mg++ binding site [ion binding]; other site 1173020001328 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1173020001329 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1173020001330 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1173020001331 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1173020001332 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1173020001333 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1173020001334 WGR domain of bacterial DNA ligases; Region: WGR_DNA_ligase; cd07998 1173020001335 HEAT repeats; Region: HEAT_2; pfam13646 1173020001336 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020001337 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020001338 structural tetrad; other site 1173020001339 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020001340 structural tetrad; other site 1173020001341 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173020001342 sequence-specific DNA binding site [nucleotide binding]; other site 1173020001343 salt bridge; other site 1173020001344 TPR repeat; Region: TPR_11; pfam13414 1173020001345 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173020001346 binding surface 1173020001347 TPR motif; other site 1173020001348 Leucine rich repeat; Region: LRR_8; pfam13855 1173020001349 Leucine rich repeat; Region: LRR_8; pfam13855 1173020001350 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1173020001351 Peptidase family M50; Region: Peptidase_M50; pfam02163 1173020001352 active site 1173020001353 putative substrate binding region [chemical binding]; other site 1173020001354 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1173020001355 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1173020001356 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1173020001357 Substrate binding site; other site 1173020001358 Cupin domain; Region: Cupin_2; cl17218 1173020001359 flavoprotein, HI0933 family; Region: TIGR00275 1173020001360 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 1173020001361 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173020001362 catalytic residues [active] 1173020001363 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1173020001364 Terminase small subunit; Region: Terminase_2; cl01513 1173020001365 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1173020001366 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020001367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020001368 active site 1173020001369 phosphorylation site [posttranslational modification] 1173020001370 intermolecular recognition site; other site 1173020001371 dimerization interface [polypeptide binding]; other site 1173020001372 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1173020001373 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173020001374 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173020001375 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1173020001376 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 1173020001377 putative active site [active] 1173020001378 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173020001379 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1173020001380 Walker A/P-loop; other site 1173020001381 ATP binding site [chemical binding]; other site 1173020001382 Q-loop/lid; other site 1173020001383 ABC transporter signature motif; other site 1173020001384 Walker B; other site 1173020001385 D-loop; other site 1173020001386 H-loop/switch region; other site 1173020001387 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1173020001388 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173020001389 non-specific DNA binding site [nucleotide binding]; other site 1173020001390 salt bridge; other site 1173020001391 sequence-specific DNA binding site [nucleotide binding]; other site 1173020001392 Double zinc ribbon; Region: DZR; pfam12773 1173020001393 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1173020001394 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020001395 active site 1173020001396 DNA binding site [nucleotide binding] 1173020001397 Int/Topo IB signature motif; other site 1173020001398 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1173020001399 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1173020001400 Phosphotransferase enzyme family; Region: APH; pfam01636 1173020001401 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1173020001402 Transposase domain (DUF772); Region: DUF772; pfam05598 1173020001403 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020001404 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1173020001405 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020001406 dimer interface [polypeptide binding]; other site 1173020001407 phosphorylation site [posttranslational modification] 1173020001408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020001409 ATP binding site [chemical binding]; other site 1173020001410 Mg2+ binding site [ion binding]; other site 1173020001411 G-X-G motif; other site 1173020001412 Stage II sporulation protein; Region: SpoIID; pfam08486 1173020001413 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1173020001414 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1173020001415 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1173020001416 inhibitor-cofactor binding pocket; inhibition site 1173020001417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020001418 catalytic residue [active] 1173020001419 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1173020001420 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1173020001421 active site 1173020001422 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 1173020001423 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1173020001424 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1173020001425 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173020001426 putative DNA binding site [nucleotide binding]; other site 1173020001427 putative Zn2+ binding site [ion binding]; other site 1173020001428 TPR repeat; Region: TPR_11; pfam13414 1173020001429 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020001430 binding surface 1173020001431 TPR motif; other site 1173020001432 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173020001433 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020001434 binding surface 1173020001435 TPR motif; other site 1173020001436 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020001437 TPR motif; other site 1173020001438 binding surface 1173020001439 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 1173020001440 DctM-like transporters; Region: DctM; pfam06808 1173020001441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020001442 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020001443 active site 1173020001444 phosphorylation site [posttranslational modification] 1173020001445 intermolecular recognition site; other site 1173020001446 dimerization interface [polypeptide binding]; other site 1173020001447 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 1173020001448 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173020001449 FeS/SAM binding site; other site 1173020001450 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 1173020001451 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1173020001452 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1173020001453 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1173020001454 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1173020001455 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1173020001456 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020001457 Walker A motif; other site 1173020001458 ATP binding site [chemical binding]; other site 1173020001459 Walker B motif; other site 1173020001460 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1173020001461 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1173020001462 active site 1173020001463 catalytic residues [active] 1173020001464 metal binding site [ion binding]; metal-binding site 1173020001465 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1173020001466 active site 1173020001467 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 1173020001468 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1173020001469 dimerization interface [polypeptide binding]; other site 1173020001470 active site 1173020001471 metal binding site [ion binding]; metal-binding site 1173020001472 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1173020001473 dsRNA binding site [nucleotide binding]; other site 1173020001474 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1173020001475 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1173020001476 23S rRNA binding site [nucleotide binding]; other site 1173020001477 L21 binding site [polypeptide binding]; other site 1173020001478 L13 binding site [polypeptide binding]; other site 1173020001479 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1173020001480 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1173020001481 substrate binding pocket [chemical binding]; other site 1173020001482 membrane-bound complex binding site; other site 1173020001483 hinge residues; other site 1173020001484 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1173020001485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020001486 putative substrate translocation pore; other site 1173020001487 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1173020001488 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1173020001489 NADP binding site [chemical binding]; other site 1173020001490 homodimer interface [polypeptide binding]; other site 1173020001491 active site 1173020001492 substrate binding site [chemical binding]; other site 1173020001493 Predicted transcriptional regulators [Transcription]; Region: COG1733 1173020001494 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1173020001495 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020001496 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1173020001497 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1173020001498 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1173020001499 ATP binding site [chemical binding]; other site 1173020001500 active site 1173020001501 substrate binding site [chemical binding]; other site 1173020001502 chloroplast envelope protein translocase, IAP75 family; Region: 3a0901s03IAP75; TIGR00992 1173020001503 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1173020001504 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1173020001505 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1173020001506 Surface antigen; Region: Bac_surface_Ag; pfam01103 1173020001507 NADH dehydrogenase subunit 1; Region: ndhA; CHL00032 1173020001508 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1173020001509 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 1173020001510 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1173020001511 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1173020001512 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1173020001513 NADH dehydrogenase subunit 4L; Region: ndhE; CHL00015 1173020001514 putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947 1173020001515 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1173020001516 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1173020001517 O-Antigen ligase; Region: Wzy_C; pfam04932 1173020001518 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173020001519 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1173020001520 HSP70 interaction site [polypeptide binding]; other site 1173020001521 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1173020001522 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173020001523 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1173020001524 protein binding site [polypeptide binding]; other site 1173020001525 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020001526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020001527 active site 1173020001528 phosphorylation site [posttranslational modification] 1173020001529 intermolecular recognition site; other site 1173020001530 dimerization interface [polypeptide binding]; other site 1173020001531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020001532 binding surface 1173020001533 TPR motif; other site 1173020001534 TPR repeat; Region: TPR_11; pfam13414 1173020001535 TPR repeat; Region: TPR_11; pfam13414 1173020001536 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020001537 TPR motif; other site 1173020001538 TPR repeat; Region: TPR_11; pfam13414 1173020001539 binding surface 1173020001540 Tetratricopeptide repeat; Region: TPR_9; pfam13371 1173020001541 CHASE2 domain; Region: CHASE2; pfam05226 1173020001542 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173020001543 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173020001544 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020001545 active site 1173020001546 ATP binding site [chemical binding]; other site 1173020001547 substrate binding site [chemical binding]; other site 1173020001548 activation loop (A-loop); other site 1173020001549 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173020001550 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1173020001551 putative C-terminal domain interface [polypeptide binding]; other site 1173020001552 putative GSH binding site (G-site) [chemical binding]; other site 1173020001553 putative dimer interface [polypeptide binding]; other site 1173020001554 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1173020001555 dimer interface [polypeptide binding]; other site 1173020001556 N-terminal domain interface [polypeptide binding]; other site 1173020001557 substrate binding pocket (H-site) [chemical binding]; other site 1173020001558 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173020001559 NMT1-like family; Region: NMT1_2; pfam13379 1173020001560 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1173020001561 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1173020001562 FMN binding site [chemical binding]; other site 1173020001563 active site 1173020001564 catalytic residues [active] 1173020001565 substrate binding site [chemical binding]; other site 1173020001566 Photosystem II complex subunit Ycf12; Region: PSII_Ycf12; cl12139 1173020001567 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1173020001568 Predicted membrane protein [Function unknown]; Region: COG2119 1173020001569 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1173020001570 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173020001571 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1173020001572 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020001573 putative active site [active] 1173020001574 endonuclease VIII; Provisional; Region: PRK10445 1173020001575 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 1173020001576 DNA binding site [nucleotide binding] 1173020001577 catalytic residue [active] 1173020001578 putative catalytic residues [active] 1173020001579 H2TH interface [polypeptide binding]; other site 1173020001580 intercalation triad [nucleotide binding]; other site 1173020001581 substrate specificity determining residue; other site 1173020001582 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1173020001583 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1173020001584 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1173020001585 Tetramer interface [polypeptide binding]; other site 1173020001586 active site 1173020001587 FMN-binding site [chemical binding]; other site 1173020001588 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1173020001589 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1173020001590 dimerization interface [polypeptide binding]; other site 1173020001591 putative ATP binding site [chemical binding]; other site 1173020001592 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1173020001593 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1173020001594 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1173020001595 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1173020001596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020001597 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173020001598 putative substrate translocation pore; other site 1173020001599 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020001600 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1173020001601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020001602 S-adenosylmethionine binding site [chemical binding]; other site 1173020001603 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 1173020001604 Protein of unknown function DUF111; Region: DUF111; cl03398 1173020001605 hypothetical protein; Provisional; Region: PRK04194 1173020001606 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1173020001607 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1173020001608 putative ligand binding site [chemical binding]; other site 1173020001609 putative NAD binding site [chemical binding]; other site 1173020001610 catalytic site [active] 1173020001611 putative phosphoketolase; Provisional; Region: PRK05261 1173020001612 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1173020001613 TPP-binding site; other site 1173020001614 XFP C-terminal domain; Region: XFP_C; pfam09363 1173020001615 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1173020001616 putative active site pocket [active] 1173020001617 dimerization interface [polypeptide binding]; other site 1173020001618 putative catalytic residue [active] 1173020001619 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1173020001620 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020001621 motif II; other site 1173020001622 Z1 domain; Region: Z1; pfam10593 1173020001623 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1173020001624 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1173020001625 [2Fe-2S] cluster binding site [ion binding]; other site 1173020001626 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1173020001627 hydrophobic ligand binding site; other site 1173020001628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1173020001629 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1173020001630 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1173020001631 DNA-binding site [nucleotide binding]; DNA binding site 1173020001632 FCD domain; Region: FCD; pfam07729 1173020001633 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1173020001634 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1173020001635 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020001636 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1173020001637 NMT1/THI5 like; Region: NMT1; pfam09084 1173020001638 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1173020001639 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1173020001640 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173020001641 Walker A/P-loop; other site 1173020001642 ATP binding site [chemical binding]; other site 1173020001643 Q-loop/lid; other site 1173020001644 ABC transporter signature motif; other site 1173020001645 Walker B; other site 1173020001646 D-loop; other site 1173020001647 H-loop/switch region; other site 1173020001648 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1173020001649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020001650 dimer interface [polypeptide binding]; other site 1173020001651 conserved gate region; other site 1173020001652 putative PBP binding loops; other site 1173020001653 ABC-ATPase subunit interface; other site 1173020001654 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173020001655 dimerization interface [polypeptide binding]; other site 1173020001656 putative DNA binding site [nucleotide binding]; other site 1173020001657 putative Zn2+ binding site [ion binding]; other site 1173020001658 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020001659 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020001660 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020001661 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020001662 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020001663 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1173020001664 homodimer interface [polypeptide binding]; other site 1173020001665 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1173020001666 active site pocket [active] 1173020001667 extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262 1173020001668 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1173020001669 substrate binding pocket [chemical binding]; other site 1173020001670 membrane-bound complex binding site; other site 1173020001671 hinge residues; other site 1173020001672 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173020001673 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020001674 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020001675 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 1173020001676 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 1173020001677 Predicted membrane protein [Function unknown]; Region: COG4244 1173020001678 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020001679 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020001680 6-phosphofructokinase; Provisional; Region: PRK14071 1173020001681 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1173020001682 active site 1173020001683 ADP/pyrophosphate binding site [chemical binding]; other site 1173020001684 dimerization interface [polypeptide binding]; other site 1173020001685 allosteric effector site; other site 1173020001686 fructose-1,6-bisphosphate binding site; other site 1173020001687 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1173020001688 AAA ATPase domain; Region: AAA_16; pfam13191 1173020001689 NACHT domain; Region: NACHT; pfam05729 1173020001690 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1173020001691 MutS domain III; Region: MutS_III; pfam05192 1173020001692 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020001693 Walker A/P-loop; other site 1173020001694 ATP binding site [chemical binding]; other site 1173020001695 Q-loop/lid; other site 1173020001696 ABC transporter signature motif; other site 1173020001697 Walker B; other site 1173020001698 D-loop; other site 1173020001699 H-loop/switch region; other site 1173020001700 Smr domain; Region: Smr; pfam01713 1173020001701 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020001702 putative active site [active] 1173020001703 PemK-like protein; Region: PemK; pfam02452 1173020001704 Predicted transcriptional regulators [Transcription]; Region: COG1695 1173020001705 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1173020001706 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020001707 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020001708 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020001709 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020001710 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020001711 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1173020001712 active site 1173020001713 dinuclear metal binding site [ion binding]; other site 1173020001714 dimerization interface [polypeptide binding]; other site 1173020001715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020001716 Coenzyme A binding pocket [chemical binding]; other site 1173020001717 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1173020001718 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1173020001719 ABC-ATPase subunit interface; other site 1173020001720 dimer interface [polypeptide binding]; other site 1173020001721 putative PBP binding regions; other site 1173020001722 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1173020001723 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1173020001724 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1173020001725 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1173020001726 metal binding site [ion binding]; metal-binding site 1173020001727 homoserine kinase; Provisional; Region: PRK01212 1173020001728 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1173020001729 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1173020001730 30S subunit binding site; other site 1173020001731 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173020001732 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173020001733 phosphopeptide binding site; other site 1173020001734 Transglycosylase; Region: Transgly; pfam00912 1173020001735 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1173020001736 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1173020001737 Protein kinase domain; Region: Pkinase; pfam00069 1173020001738 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020001739 active site 1173020001740 ATP binding site [chemical binding]; other site 1173020001741 substrate binding site [chemical binding]; other site 1173020001742 activation loop (A-loop); other site 1173020001743 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 1173020001744 active site 1173020001745 catalytic triad [active] 1173020001746 oxyanion hole [active] 1173020001747 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1173020001748 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 1173020001749 active site 1173020001750 catalytic triad [active] 1173020001751 oxyanion hole [active] 1173020001752 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 1173020001753 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 1173020001754 multimerization interface [polypeptide binding]; other site 1173020001755 RbcX protein; Region: RcbX; pfam02341 1173020001756 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 1173020001757 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 1173020001758 homodimer interface [polypeptide binding]; other site 1173020001759 active site 1173020001760 heterodimer interface [polypeptide binding]; other site 1173020001761 catalytic residue [active] 1173020001762 metal binding site [ion binding]; metal-binding site 1173020001763 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1173020001764 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1173020001765 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1173020001766 hydrolase, alpha/beta fold family protein; Region: PLN02824 1173020001767 Serine hydrolase; Region: Ser_hydrolase; cl17834 1173020001768 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 1173020001769 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1173020001770 putative valine binding site [chemical binding]; other site 1173020001771 dimer interface [polypeptide binding]; other site 1173020001772 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1173020001773 KaiA domain; Region: KaiA; pfam07688 1173020001774 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1173020001775 tetramer interface [polypeptide binding]; other site 1173020001776 dimer interface [polypeptide binding]; other site 1173020001777 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 1173020001778 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 1173020001779 Walker A motif; other site 1173020001780 ATP binding site [chemical binding]; other site 1173020001781 Walker B motif; other site 1173020001782 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173020001783 ATP binding site [chemical binding]; other site 1173020001784 Walker B motif; other site 1173020001785 FOG: CBS domain [General function prediction only]; Region: COG0517 1173020001786 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1173020001787 FOG: CBS domain [General function prediction only]; Region: COG0517 1173020001788 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 1173020001789 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 1173020001790 AIR carboxylase; Region: AIRC; smart01001 1173020001791 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870 1173020001792 UbiA prenyltransferase family; Region: UbiA; pfam01040 1173020001793 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020001794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020001795 active site 1173020001796 phosphorylation site [posttranslational modification] 1173020001797 intermolecular recognition site; other site 1173020001798 dimerization interface [polypeptide binding]; other site 1173020001799 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020001800 DNA binding site [nucleotide binding] 1173020001801 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1173020001802 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1173020001803 Surface antigen; Region: Bac_surface_Ag; pfam01103 1173020001804 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1173020001805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173020001806 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1173020001807 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1173020001808 NAD(P) binding site [chemical binding]; other site 1173020001809 catalytic residues [active] 1173020001810 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1173020001811 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 1173020001812 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1173020001813 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173020001814 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173020001815 putative binding surface; other site 1173020001816 active site 1173020001817 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173020001818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020001819 ATP binding site [chemical binding]; other site 1173020001820 Mg2+ binding site [ion binding]; other site 1173020001821 G-X-G motif; other site 1173020001822 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173020001823 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020001824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020001825 active site 1173020001826 phosphorylation site [posttranslational modification] 1173020001827 intermolecular recognition site; other site 1173020001828 dimerization interface [polypeptide binding]; other site 1173020001829 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020001830 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173020001831 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020001832 acetolactate synthase; Reviewed; Region: PRK08322 1173020001833 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1173020001834 PYR/PP interface [polypeptide binding]; other site 1173020001835 dimer interface [polypeptide binding]; other site 1173020001836 TPP binding site [chemical binding]; other site 1173020001837 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1173020001838 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1173020001839 TPP-binding site [chemical binding]; other site 1173020001840 dimer interface [polypeptide binding]; other site 1173020001841 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 1173020001842 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1173020001843 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1173020001844 NAD(P) binding site [chemical binding]; other site 1173020001845 catalytic residues [active] 1173020001846 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1173020001847 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1173020001848 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 1173020001849 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1173020001850 dimerization interface [polypeptide binding]; other site 1173020001851 active site 1173020001852 short chain dehydrogenase; Validated; Region: PRK06182 1173020001853 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1173020001854 NADP binding site [chemical binding]; other site 1173020001855 active site 1173020001856 steroid binding site; other site 1173020001857 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1173020001858 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1173020001859 NAD(P) binding site [chemical binding]; other site 1173020001860 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1173020001861 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1173020001862 NADP binding site [chemical binding]; other site 1173020001863 active site 1173020001864 putative substrate binding site [chemical binding]; other site 1173020001865 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020001866 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1173020001867 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020001868 putative ADP-binding pocket [chemical binding]; other site 1173020001869 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173020001870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020001871 active site 1173020001872 phosphorylation site [posttranslational modification] 1173020001873 intermolecular recognition site; other site 1173020001874 dimerization interface [polypeptide binding]; other site 1173020001875 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173020001876 DNA binding residues [nucleotide binding] 1173020001877 dimerization interface [polypeptide binding]; other site 1173020001878 magnesium chelatase subunit H; Provisional; Region: PRK12493 1173020001879 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1173020001880 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1173020001881 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 1173020001882 active site 1173020001883 NTP binding site [chemical binding]; other site 1173020001884 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1173020001885 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1173020001886 cofactor binding site; other site 1173020001887 DNA binding site [nucleotide binding] 1173020001888 substrate interaction site [chemical binding]; other site 1173020001889 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173020001890 non-specific DNA binding site [nucleotide binding]; other site 1173020001891 salt bridge; other site 1173020001892 sequence-specific DNA binding site [nucleotide binding]; other site 1173020001893 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1173020001894 Family description; Region: UvrD_C_2; pfam13538 1173020001895 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173020001896 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1173020001897 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1173020001898 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173020001899 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1173020001900 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1173020001901 GIY-YIG motif/motif A; other site 1173020001902 active site 1173020001903 catalytic site [active] 1173020001904 putative DNA binding site [nucleotide binding]; other site 1173020001905 metal binding site [ion binding]; metal-binding site 1173020001906 UvrB/uvrC motif; Region: UVR; pfam02151 1173020001907 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1173020001908 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173020001909 HSP70 interaction site [polypeptide binding]; other site 1173020001910 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020001911 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020001912 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020001913 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1173020001914 putative hydrophobic ligand binding site [chemical binding]; other site 1173020001915 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 1173020001916 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173020001917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1173020001918 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1173020001919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020001920 S-adenosylmethionine binding site [chemical binding]; other site 1173020001921 Late competence development protein ComFB; Region: ComFB; pfam10719 1173020001922 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1173020001923 Peptidase family M23; Region: Peptidase_M23; pfam01551 1173020001924 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1173020001925 putative cation:proton antiport protein; Provisional; Region: PRK10669 1173020001926 TrkA-N domain; Region: TrkA_N; pfam02254 1173020001927 TrkA-C domain; Region: TrkA_C; pfam02080 1173020001928 Sm and related proteins; Region: Sm_like; cl00259 1173020001929 heptamer interface [polypeptide binding]; other site 1173020001930 Sm1 motif; other site 1173020001931 hexamer interface [polypeptide binding]; other site 1173020001932 RNA binding site [nucleotide binding]; other site 1173020001933 Sm2 motif; other site 1173020001934 Nuclease A inhibitor-like protein; Region: NuiA; pfam07924 1173020001935 DNA helicase IV; Provisional; Region: helD; PRK11054 1173020001936 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1173020001937 dimerization interface [polypeptide binding]; other site 1173020001938 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1173020001939 thioester formation/cholesterol transfer; other site 1173020001940 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1173020001941 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1173020001942 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1173020001943 ATP binding site [chemical binding]; other site 1173020001944 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1173020001945 dimerization interface [polypeptide binding]; other site 1173020001946 ATP binding site [chemical binding]; other site 1173020001947 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1173020001948 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1173020001949 ribosomal protein S14; Region: rps14; CHL00074 1173020001950 Predicted membrane protein [Function unknown]; Region: COG2324 1173020001951 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173020001952 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1173020001953 active site 1173020001954 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 1173020001955 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1173020001956 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1173020001957 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1173020001958 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1173020001959 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1173020001960 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1173020001961 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1173020001962 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 1173020001963 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1173020001964 dimer interface [polypeptide binding]; other site 1173020001965 motif 1; other site 1173020001966 active site 1173020001967 motif 2; other site 1173020001968 motif 3; other site 1173020001969 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1173020001970 anticodon binding site; other site 1173020001971 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1173020001972 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 1173020001973 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1173020001974 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1173020001975 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173020001976 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1173020001977 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173020001978 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173020001979 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173020001980 ligand binding site [chemical binding]; other site 1173020001981 flexible hinge region; other site 1173020001982 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1173020001983 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 1173020001984 putative active site [active] 1173020001985 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173020001986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020001987 Walker A/P-loop; other site 1173020001988 ATP binding site [chemical binding]; other site 1173020001989 Q-loop/lid; other site 1173020001990 ABC transporter signature motif; other site 1173020001991 Walker B; other site 1173020001992 D-loop; other site 1173020001993 H-loop/switch region; other site 1173020001994 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1173020001995 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1173020001996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020001997 S-adenosylmethionine binding site [chemical binding]; other site 1173020001998 putative lyase; Provisional; Region: PRK09687 1173020001999 Protein of unknown function DUF72; Region: DUF72; pfam01904 1173020002000 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1173020002001 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1173020002002 HIGH motif; other site 1173020002003 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1173020002004 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1173020002005 active site 1173020002006 KMSKS motif; other site 1173020002007 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1173020002008 tRNA binding surface [nucleotide binding]; other site 1173020002009 anticodon binding site; other site 1173020002010 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1173020002011 PRC-barrel domain; Region: PRC; pfam05239 1173020002012 PRC-barrel domain; Region: PRC; pfam05239 1173020002013 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1173020002014 phosphatidate cytidylyltransferase; Region: PLN02953 1173020002015 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1173020002016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020002017 S-adenosylmethionine binding site [chemical binding]; other site 1173020002018 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1173020002019 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1173020002020 homodimer interface [polypeptide binding]; other site 1173020002021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020002022 catalytic residue [active] 1173020002023 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1173020002024 phycobillisome linker protein; Region: apcE; CHL00091 1173020002025 Phycobilisome protein; Region: Phycobilisome; cl08227 1173020002026 Phycobilisome protein; Region: Phycobilisome; cl08227 1173020002027 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173020002028 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173020002029 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173020002030 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173020002031 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1173020002032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1173020002033 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1173020002034 HEAT repeats; Region: HEAT_2; pfam13646 1173020002035 HEAT repeats; Region: HEAT_2; pfam13646 1173020002036 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1173020002037 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1173020002038 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1173020002039 Mg++ binding site [ion binding]; other site 1173020002040 putative catalytic motif [active] 1173020002041 putative substrate binding site [chemical binding]; other site 1173020002042 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 1173020002043 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 1173020002044 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1173020002045 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1173020002046 C-terminal peptidase (prc); Region: prc; TIGR00225 1173020002047 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1173020002048 protein binding site [polypeptide binding]; other site 1173020002049 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1173020002050 Catalytic dyad [active] 1173020002051 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1173020002052 active site 1173020002053 metal binding site [ion binding]; metal-binding site 1173020002054 interdomain interaction site; other site 1173020002055 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020002056 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020002057 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020002058 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020002059 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020002060 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1173020002061 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1173020002062 putative active site [active] 1173020002063 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1173020002064 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1173020002065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173020002066 NAD(P) binding site [chemical binding]; other site 1173020002067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173020002068 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1173020002069 active site 1173020002070 Leucine rich repeat; Region: LRR_8; pfam13855 1173020002071 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173020002072 Leucine rich repeat; Region: LRR_8; pfam13855 1173020002073 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173020002074 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1173020002075 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1173020002076 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1173020002077 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1173020002078 antiporter inner membrane protein; Provisional; Region: PRK11670 1173020002079 Domain of unknown function DUF59; Region: DUF59; pfam01883 1173020002080 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1173020002081 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 1173020002082 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 1173020002083 Probable Catalytic site; other site 1173020002084 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 1173020002085 Opioid growth factor receptor (OGFr) conserved region; Region: OGFr_N; pfam04664 1173020002086 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1173020002087 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 1173020002088 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1173020002089 PYR/PP interface [polypeptide binding]; other site 1173020002090 dimer interface [polypeptide binding]; other site 1173020002091 TPP binding site [chemical binding]; other site 1173020002092 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1173020002093 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1173020002094 TPP-binding site [chemical binding]; other site 1173020002095 dimer interface [polypeptide binding]; other site 1173020002096 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1173020002097 Predicted flavoprotein [General function prediction only]; Region: COG0431 1173020002098 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1173020002099 chaperonin GroL; Region: GroEL; TIGR02348 1173020002100 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1173020002101 ABC1 family; Region: ABC1; cl17513 1173020002102 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1173020002103 active site 1173020002104 HaeII restriction endonuclease; Region: RE_HaeII; pfam09554 1173020002105 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1173020002106 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 1173020002107 cofactor binding site; other site 1173020002108 DNA binding site [nucleotide binding] 1173020002109 substrate interaction site [chemical binding]; other site 1173020002110 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 1173020002111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020002112 Walker A/P-loop; other site 1173020002113 ATP binding site [chemical binding]; other site 1173020002114 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020002115 ABC transporter signature motif; other site 1173020002116 Walker B; other site 1173020002117 D-loop; other site 1173020002118 H-loop/switch region; other site 1173020002119 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173020002120 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1173020002121 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173020002122 putative acyl-acceptor binding pocket; other site 1173020002123 Putative integral membrane protein (DUF2391); Region: DUF2391; pfam09622 1173020002124 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 1173020002125 TIGR02588 family protein; Region: TIGR02588 1173020002126 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1173020002127 cobyric acid synthase; Provisional; Region: PRK00784 1173020002128 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1173020002129 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1173020002130 catalytic triad [active] 1173020002131 TPR repeat; Region: TPR_11; pfam13414 1173020002132 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020002133 binding surface 1173020002134 TPR motif; other site 1173020002135 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1173020002136 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1173020002137 Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596 1173020002138 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1173020002139 EVE domain; Region: EVE; cl00728 1173020002140 AAA ATPase domain; Region: AAA_16; pfam13191 1173020002141 NB-ARC domain; Region: NB-ARC; pfam00931 1173020002142 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020002143 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020002144 structural tetrad; other site 1173020002145 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020002146 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020002147 structural tetrad; other site 1173020002148 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 1173020002149 Calx-beta domain; Region: Calx-beta; cl02522 1173020002150 Calx-beta domain; Region: Calx-beta; cl02522 1173020002151 Calx-beta domain; Region: Calx-beta; cl02522 1173020002152 Calx-beta domain; Region: Calx-beta; cl02522 1173020002153 Calx-beta domain; Region: Calx-beta; pfam03160 1173020002154 Calx-beta domain; Region: Calx-beta; cl02522 1173020002155 Calx-beta domain; Region: Calx-beta; pfam03160 1173020002156 Calx-beta domain; Region: Calx-beta; cl02522 1173020002157 Calx-beta domain; Region: Calx-beta; cl02522 1173020002158 Calx-beta domain; Region: Calx-beta; cl02522 1173020002159 Calx-beta domain; Region: Calx-beta; pfam03160 1173020002160 Calx-beta domain; Region: Calx-beta; cl02522 1173020002161 Calx-beta domain; Region: Calx-beta; cl02522 1173020002162 Calx-beta domain; Region: Calx-beta; cl02522 1173020002163 Calx-beta domain; Region: Calx-beta; pfam03160 1173020002164 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020002165 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020002166 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020002167 Phycobilisome protein; Region: Phycobilisome; cl08227 1173020002168 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173020002169 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1173020002170 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1173020002171 Walker A/P-loop; other site 1173020002172 ATP binding site [chemical binding]; other site 1173020002173 Q-loop/lid; other site 1173020002174 ABC transporter signature motif; other site 1173020002175 Walker B; other site 1173020002176 D-loop; other site 1173020002177 H-loop/switch region; other site 1173020002178 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1173020002179 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1173020002180 putative NAD(P) binding site [chemical binding]; other site 1173020002181 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173020002182 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173020002183 catalytic core [active] 1173020002184 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1173020002185 active site 1173020002186 catalytic site [active] 1173020002187 substrate binding site [chemical binding]; other site 1173020002188 proline aminopeptidase P II; Provisional; Region: PRK10879 1173020002189 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1173020002190 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1173020002191 active site 1173020002192 glutamate carboxypeptidase; Reviewed; Region: PRK06133 1173020002193 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1173020002194 metal binding site [ion binding]; metal-binding site 1173020002195 dimer interface [polypeptide binding]; other site 1173020002196 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020002197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020002198 active site 1173020002199 phosphorylation site [posttranslational modification] 1173020002200 intermolecular recognition site; other site 1173020002201 dimerization interface [polypeptide binding]; other site 1173020002202 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020002203 DNA binding site [nucleotide binding] 1173020002204 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173020002205 putative binding surface; other site 1173020002206 active site 1173020002207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1173020002208 active site 1173020002209 phosphorylation site [posttranslational modification] 1173020002210 intermolecular recognition site; other site 1173020002211 dimerization interface [polypeptide binding]; other site 1173020002212 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020002213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020002214 active site 1173020002215 phosphorylation site [posttranslational modification] 1173020002216 intermolecular recognition site; other site 1173020002217 dimerization interface [polypeptide binding]; other site 1173020002218 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020002219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020002220 active site 1173020002221 phosphorylation site [posttranslational modification] 1173020002222 intermolecular recognition site; other site 1173020002223 dimerization interface [polypeptide binding]; other site 1173020002224 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173020002225 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1173020002226 ATP-binding site [chemical binding]; other site 1173020002227 Gluconate-6-phosphate binding site [chemical binding]; other site 1173020002228 Shikimate kinase; Region: SKI; pfam01202 1173020002229 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1173020002230 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1173020002231 dimer interface [polypeptide binding]; other site 1173020002232 active site 1173020002233 acyl carrier protein; Provisional; Region: acpP; PRK00982 1173020002234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020002235 S-adenosylmethionine binding site [chemical binding]; other site 1173020002236 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173020002237 Circadian oscillating protein COP23; Region: COP23; pfam14218 1173020002238 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173020002239 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020002240 active site 1173020002241 ATP binding site [chemical binding]; other site 1173020002242 substrate binding site [chemical binding]; other site 1173020002243 activation loop (A-loop); other site 1173020002244 SnoaL-like domain; Region: SnoaL_3; pfam13474 1173020002245 SnoaL-like domain; Region: SnoaL_2; pfam12680 1173020002246 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1173020002247 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020002248 active site 1173020002249 motif I; other site 1173020002250 motif II; other site 1173020002251 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173020002252 active site 1173020002253 metal binding site [ion binding]; metal-binding site 1173020002254 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173020002255 Condensation domain; Region: Condensation; pfam00668 1173020002256 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173020002257 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173020002258 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1173020002259 acyl-activating enzyme (AAE) consensus motif; other site 1173020002260 AMP binding site [chemical binding]; other site 1173020002261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020002262 S-adenosylmethionine binding site [chemical binding]; other site 1173020002263 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1173020002264 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173020002265 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1173020002266 MarR family; Region: MarR; pfam01047 1173020002267 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1173020002268 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173020002269 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1173020002270 putative C-terminal domain interface [polypeptide binding]; other site 1173020002271 putative GSH binding site (G-site) [chemical binding]; other site 1173020002272 putative dimer interface [polypeptide binding]; other site 1173020002273 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1173020002274 N-terminal domain interface [polypeptide binding]; other site 1173020002275 dimer interface [polypeptide binding]; other site 1173020002276 substrate binding pocket (H-site) [chemical binding]; other site 1173020002277 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1173020002278 dimer interface [polypeptide binding]; other site 1173020002279 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1173020002280 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173020002281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1173020002282 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 1173020002283 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1173020002284 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173020002285 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1173020002286 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173020002287 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173020002288 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 1173020002289 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173020002290 DevC protein; Region: devC; TIGR01185 1173020002291 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1173020002292 FtsX-like permease family; Region: FtsX; pfam02687 1173020002293 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 1173020002294 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1173020002295 Walker A/P-loop; other site 1173020002296 ATP binding site [chemical binding]; other site 1173020002297 Q-loop/lid; other site 1173020002298 ABC transporter signature motif; other site 1173020002299 Walker B; other site 1173020002300 D-loop; other site 1173020002301 H-loop/switch region; other site 1173020002302 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1173020002303 MarR family; Region: MarR; pfam01047 1173020002304 EamA-like transporter family; Region: EamA; pfam00892 1173020002305 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1173020002306 EamA-like transporter family; Region: EamA; pfam00892 1173020002307 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1173020002308 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 1173020002309 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1173020002310 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1173020002311 putative ADP-binding pocket [chemical binding]; other site 1173020002312 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173020002313 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173020002314 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020002315 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020002316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020002317 active site 1173020002318 phosphorylation site [posttranslational modification] 1173020002319 intermolecular recognition site; other site 1173020002320 dimerization interface [polypeptide binding]; other site 1173020002321 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020002322 DNA binding site [nucleotide binding] 1173020002323 CHASE3 domain; Region: CHASE3; pfam05227 1173020002324 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020002325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020002326 dimer interface [polypeptide binding]; other site 1173020002327 phosphorylation site [posttranslational modification] 1173020002328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020002329 ATP binding site [chemical binding]; other site 1173020002330 G-X-G motif; other site 1173020002331 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1173020002332 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1173020002333 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1173020002334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020002335 dimer interface [polypeptide binding]; other site 1173020002336 conserved gate region; other site 1173020002337 putative PBP binding loops; other site 1173020002338 ABC-ATPase subunit interface; other site 1173020002339 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1173020002340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020002341 dimer interface [polypeptide binding]; other site 1173020002342 conserved gate region; other site 1173020002343 putative PBP binding loops; other site 1173020002344 ABC-ATPase subunit interface; other site 1173020002345 Serine endopeptidase inhibitors; Region: Inhibitor_I10; pfam12559 1173020002346 ATP-grasp ribosomal peptide maturase, MvdD family; Region: ATPgraspMvdD; TIGR04184 1173020002347 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173020002348 Condensation domain; Region: Condensation; pfam00668 1173020002349 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173020002350 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173020002351 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1173020002352 acyl-activating enzyme (AAE) consensus motif; other site 1173020002353 AMP binding site [chemical binding]; other site 1173020002354 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173020002355 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1173020002356 Condensation domain; Region: Condensation; pfam00668 1173020002357 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173020002358 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173020002359 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1173020002360 acyl-activating enzyme (AAE) consensus motif; other site 1173020002361 AMP binding site [chemical binding]; other site 1173020002362 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173020002363 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1173020002364 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 1173020002365 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1173020002366 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1173020002367 NAD(P) binding site [chemical binding]; other site 1173020002368 putative active site [active] 1173020002369 CHASE3 domain; Region: CHASE3; pfam05227 1173020002370 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020002371 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173020002372 putative active site [active] 1173020002373 heme pocket [chemical binding]; other site 1173020002374 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020002375 dimer interface [polypeptide binding]; other site 1173020002376 phosphorylation site [posttranslational modification] 1173020002377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020002378 ATP binding site [chemical binding]; other site 1173020002379 Mg2+ binding site [ion binding]; other site 1173020002380 G-X-G motif; other site 1173020002381 allantoate amidohydrolase; Reviewed; Region: PRK09290 1173020002382 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1173020002383 active site 1173020002384 metal binding site [ion binding]; metal-binding site 1173020002385 dimer interface [polypeptide binding]; other site 1173020002386 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 1173020002387 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1173020002388 active site 1173020002389 homotetramer interface [polypeptide binding]; other site 1173020002390 hypothetical protein; Provisional; Region: PRK06753 1173020002391 hypothetical protein; Provisional; Region: PRK07236 1173020002392 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1173020002393 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1173020002394 active site 1173020002395 catalytic site [active] 1173020002396 tetramer interface [polypeptide binding]; other site 1173020002397 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 1173020002398 putative active site pocket [active] 1173020002399 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1173020002400 xanthine permease; Region: pbuX; TIGR03173 1173020002401 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020002402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020002403 active site 1173020002404 phosphorylation site [posttranslational modification] 1173020002405 intermolecular recognition site; other site 1173020002406 dimerization interface [polypeptide binding]; other site 1173020002407 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1173020002408 anti sigma factor interaction site; other site 1173020002409 regulatory phosphorylation site [posttranslational modification]; other site 1173020002410 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020002411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020002412 active site 1173020002413 phosphorylation site [posttranslational modification] 1173020002414 intermolecular recognition site; other site 1173020002415 dimerization interface [polypeptide binding]; other site 1173020002416 Heme NO binding associated; Region: HNOBA; pfam07701 1173020002417 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020002418 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020002419 dimer interface [polypeptide binding]; other site 1173020002420 phosphorylation site [posttranslational modification] 1173020002421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020002422 ATP binding site [chemical binding]; other site 1173020002423 Mg2+ binding site [ion binding]; other site 1173020002424 G-X-G motif; other site 1173020002425 Heme NO binding; Region: HNOB; pfam07700 1173020002426 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 1173020002427 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 1173020002428 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1173020002429 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1173020002430 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1173020002431 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173020002432 active site 1173020002433 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 1173020002434 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173020002435 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 1173020002436 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 1173020002437 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 1173020002438 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 1173020002439 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173020002440 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173020002441 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173020002442 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173020002443 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020002444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020002445 active site 1173020002446 phosphorylation site [posttranslational modification] 1173020002447 intermolecular recognition site; other site 1173020002448 dimerization interface [polypeptide binding]; other site 1173020002449 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1173020002450 FOG: CBS domain [General function prediction only]; Region: COG0517 1173020002451 PAS fold; Region: PAS_4; pfam08448 1173020002452 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1173020002453 PAS fold; Region: PAS_3; pfam08447 1173020002454 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020002455 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020002456 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020002457 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020002458 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020002459 dimer interface [polypeptide binding]; other site 1173020002460 phosphorylation site [posttranslational modification] 1173020002461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020002462 ATP binding site [chemical binding]; other site 1173020002463 Mg2+ binding site [ion binding]; other site 1173020002464 G-X-G motif; other site 1173020002465 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020002466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020002467 active site 1173020002468 phosphorylation site [posttranslational modification] 1173020002469 intermolecular recognition site; other site 1173020002470 dimerization interface [polypeptide binding]; other site 1173020002471 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020002472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020002473 active site 1173020002474 phosphorylation site [posttranslational modification] 1173020002475 intermolecular recognition site; other site 1173020002476 dimerization interface [polypeptide binding]; other site 1173020002477 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1173020002478 active site 1173020002479 catalytic triad [active] 1173020002480 oxyanion hole [active] 1173020002481 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 1173020002482 OpgC protein; Region: OpgC_C; cl17858 1173020002483 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 1173020002484 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1173020002485 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1173020002486 FAD binding pocket [chemical binding]; other site 1173020002487 FAD binding motif [chemical binding]; other site 1173020002488 phosphate binding motif [ion binding]; other site 1173020002489 beta-alpha-beta structure motif; other site 1173020002490 NAD binding pocket [chemical binding]; other site 1173020002491 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173020002492 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173020002493 catalytic loop [active] 1173020002494 iron binding site [ion binding]; other site 1173020002495 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1173020002496 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1173020002497 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020002498 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020002499 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020002500 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1173020002501 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1173020002502 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 1173020002503 4Fe-4S binding domain; Region: Fer4; pfam00037 1173020002504 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1173020002505 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1173020002506 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1173020002507 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1173020002508 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1173020002509 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020002510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020002511 active site 1173020002512 phosphorylation site [posttranslational modification] 1173020002513 intermolecular recognition site; other site 1173020002514 dimerization interface [polypeptide binding]; other site 1173020002515 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020002516 DNA binding site [nucleotide binding] 1173020002517 methionine sulfoxide reductase A; Provisional; Region: PRK13014 1173020002518 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1173020002519 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1173020002520 Moco binding site; other site 1173020002521 metal coordination site [ion binding]; other site 1173020002522 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1173020002523 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1173020002524 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1173020002525 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020002526 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1173020002527 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173020002528 catalytic residues [active] 1173020002529 Electron transfer DM13; Region: DM13; pfam10517 1173020002530 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1173020002531 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020002532 dimer interface [polypeptide binding]; other site 1173020002533 phosphorylation site [posttranslational modification] 1173020002534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020002535 ATP binding site [chemical binding]; other site 1173020002536 Mg2+ binding site [ion binding]; other site 1173020002537 G-X-G motif; other site 1173020002538 Helix-turn-helix domain; Region: HTH_37; pfam13744 1173020002539 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1173020002540 oligomeric interface; other site 1173020002541 putative active site [active] 1173020002542 homodimer interface [polypeptide binding]; other site 1173020002543 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1173020002544 EamA-like transporter family; Region: EamA; pfam00892 1173020002545 EamA-like transporter family; Region: EamA; pfam00892 1173020002546 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1173020002547 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020002548 active site 1173020002549 ATP binding site [chemical binding]; other site 1173020002550 substrate binding site [chemical binding]; other site 1173020002551 activation loop (A-loop); other site 1173020002552 PAS domain S-box; Region: sensory_box; TIGR00229 1173020002553 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020002554 putative active site [active] 1173020002555 heme pocket [chemical binding]; other site 1173020002556 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1173020002557 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020002558 dimer interface [polypeptide binding]; other site 1173020002559 phosphorylation site [posttranslational modification] 1173020002560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020002561 ATP binding site [chemical binding]; other site 1173020002562 Mg2+ binding site [ion binding]; other site 1173020002563 G-X-G motif; other site 1173020002564 TfoX N-terminal domain; Region: TfoX_N; pfam04993 1173020002565 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173020002566 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 1173020002567 Predicted transcriptional regulators [Transcription]; Region: COG1733 1173020002568 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1173020002569 short chain dehydrogenase; Provisional; Region: PRK06172 1173020002570 classical (c) SDRs; Region: SDR_c; cd05233 1173020002571 NAD(P) binding site [chemical binding]; other site 1173020002572 active site 1173020002573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173020002574 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 1173020002575 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1173020002576 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1173020002577 Peptidase family M28; Region: Peptidase_M28; pfam04389 1173020002578 metal binding site [ion binding]; metal-binding site 1173020002579 Protein of unknown function DUF91; Region: DUF91; cl00709 1173020002580 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1173020002581 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173020002582 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1173020002583 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1173020002584 NAD binding site [chemical binding]; other site 1173020002585 substrate binding site [chemical binding]; other site 1173020002586 putative active site [active] 1173020002587 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1173020002588 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1173020002589 active site residue [active] 1173020002590 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1173020002591 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1173020002592 high affinity sulphate transporter 1; Region: sulP; TIGR00815 1173020002593 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1173020002594 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1173020002595 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1173020002596 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020002597 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020002598 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020002599 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1173020002600 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1173020002601 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; COG2082 1173020002602 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 1173020002603 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020002604 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1173020002605 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173020002606 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020002607 motif II; other site 1173020002608 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173020002609 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173020002610 putative switch regulator; other site 1173020002611 non-specific DNA interactions [nucleotide binding]; other site 1173020002612 DNA binding site [nucleotide binding] 1173020002613 sequence specific DNA binding site [nucleotide binding]; other site 1173020002614 putative cAMP binding site [chemical binding]; other site 1173020002615 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1173020002616 metal binding site 2 [ion binding]; metal-binding site 1173020002617 putative DNA binding helix; other site 1173020002618 metal binding site 1 [ion binding]; metal-binding site 1173020002619 dimer interface [polypeptide binding]; other site 1173020002620 structural Zn2+ binding site [ion binding]; other site 1173020002621 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 1173020002622 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1173020002623 Lamin Tail Domain; Region: LTD; pfam00932 1173020002624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 1173020002625 SdiA-regulated; Region: SdiA-regulated; cd09971 1173020002626 putative active site [active] 1173020002627 Lamin Tail Domain; Region: LTD; pfam00932 1173020002628 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1173020002629 Synechococcus sp. strain PCC 7942 PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162 1173020002630 putative active site [active] 1173020002631 putative metal binding site [ion binding]; other site 1173020002632 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1173020002633 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1173020002634 active site 1173020002635 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1173020002636 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1173020002637 active site 1173020002638 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173020002639 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 1173020002640 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173020002641 dimerization interface [polypeptide binding]; other site 1173020002642 putative DNA binding site [nucleotide binding]; other site 1173020002643 putative Zn2+ binding site [ion binding]; other site 1173020002644 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1173020002645 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1173020002646 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1173020002647 intersubunit interface [polypeptide binding]; other site 1173020002648 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 1173020002649 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1173020002650 active site residue [active] 1173020002651 Protein kinase domain; Region: Pkinase; pfam00069 1173020002652 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020002653 active site 1173020002654 ATP binding site [chemical binding]; other site 1173020002655 substrate binding site [chemical binding]; other site 1173020002656 activation loop (A-loop); other site 1173020002657 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1173020002658 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1173020002659 active site 1173020002660 trimer interface [polypeptide binding]; other site 1173020002661 allosteric site; other site 1173020002662 active site lid [active] 1173020002663 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1173020002664 putative anti-sigmaE protein; Provisional; Region: PRK13920 1173020002665 RNA polymerase sigma factor; Provisional; Region: PRK12519 1173020002666 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173020002667 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173020002668 DNA binding residues [nucleotide binding] 1173020002669 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1173020002670 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 1173020002671 active site 1173020002672 catalytic site [active] 1173020002673 metal binding site [ion binding]; metal-binding site 1173020002674 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1173020002675 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173020002676 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1173020002677 TPR repeat; Region: TPR_11; pfam13414 1173020002678 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020002679 binding surface 1173020002680 TPR motif; other site 1173020002681 TPR repeat; Region: TPR_11; pfam13414 1173020002682 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020002683 binding surface 1173020002684 TPR motif; other site 1173020002685 TPR repeat; Region: TPR_11; pfam13414 1173020002686 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 1173020002687 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 1173020002688 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1173020002689 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173020002690 ATP binding site [chemical binding]; other site 1173020002691 putative Mg++ binding site [ion binding]; other site 1173020002692 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173020002693 nucleotide binding region [chemical binding]; other site 1173020002694 ATP-binding site [chemical binding]; other site 1173020002695 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1173020002696 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173020002697 ATP binding site [chemical binding]; other site 1173020002698 putative Mg++ binding site [ion binding]; other site 1173020002699 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173020002700 nucleotide binding region [chemical binding]; other site 1173020002701 ATP-binding site [chemical binding]; other site 1173020002702 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1173020002703 homotrimer interaction site [polypeptide binding]; other site 1173020002704 putative active site [active] 1173020002705 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173020002706 active site 1173020002707 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1173020002708 DNA protecting protein DprA; Region: dprA; TIGR00732 1173020002709 Helix-turn-helix domain; Region: HTH_37; pfam13744 1173020002710 non-specific DNA binding site [nucleotide binding]; other site 1173020002711 salt bridge; other site 1173020002712 sequence-specific DNA binding site [nucleotide binding]; other site 1173020002713 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1173020002714 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1173020002715 HicB family; Region: HicB; pfam05534 1173020002716 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 1173020002717 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 1173020002718 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1173020002719 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1173020002720 Beta-Casp domain; Region: Beta-Casp; smart01027 1173020002721 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1173020002722 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173020002723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020002724 S-adenosylmethionine binding site [chemical binding]; other site 1173020002725 RNA ligase, DRB0094 family; Region: RNA_lig_DRB0094; TIGR02306 1173020002726 RNA ligase; Region: RNA_ligase; pfam09414 1173020002727 SnoaL-like domain; Region: SnoaL_2; pfam12680 1173020002728 Uncharacterized conserved protein [Function unknown]; Region: COG4095 1173020002729 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1173020002730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1173020002731 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1173020002732 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1173020002733 hydrolase, alpha/beta fold family protein; Region: PLN02824 1173020002734 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173020002735 TAP-like protein; Region: Abhydrolase_4; pfam08386 1173020002736 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1173020002737 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1173020002738 TAP-like protein; Region: Abhydrolase_4; pfam08386 1173020002739 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1173020002740 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1173020002741 Ycf46; Provisional; Region: ycf46; CHL00195 1173020002742 Ycf46; Provisional; Region: ycf46; CHL00195 1173020002743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020002744 Walker A motif; other site 1173020002745 ATP binding site [chemical binding]; other site 1173020002746 Walker B motif; other site 1173020002747 arginine finger; other site 1173020002748 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1173020002749 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1173020002750 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 1173020002751 PIN domain; Region: PIN_3; pfam13470 1173020002752 DNA binding domain, excisionase family; Region: excise; TIGR01764 1173020002753 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 1173020002754 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1173020002755 GrpE; Region: GrpE; pfam01025 1173020002756 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 1173020002757 dimer interface [polypeptide binding]; other site 1173020002758 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1173020002759 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1173020002760 nucleotide binding site [chemical binding]; other site 1173020002761 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1173020002762 SBD interface [polypeptide binding]; other site 1173020002763 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 1173020002764 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173020002765 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1173020002766 Leucine-rich repeats; other site 1173020002767 Substrate binding site [chemical binding]; other site 1173020002768 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1173020002769 coproporphyrinogen III oxidase; Validated; Region: PRK08208 1173020002770 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173020002771 FeS/SAM binding site; other site 1173020002772 HemN C-terminal domain; Region: HemN_C; pfam06969 1173020002773 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173020002774 FeS/SAM binding site; other site 1173020002775 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173020002776 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173020002777 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173020002778 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173020002779 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173020002780 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1173020002781 DNA methylase; Region: N6_N4_Mtase; cl17433 1173020002782 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1173020002783 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 1173020002784 NADP binding site [chemical binding]; other site 1173020002785 homodimer interface [polypeptide binding]; other site 1173020002786 active site 1173020002787 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020002788 putative active site [active] 1173020002789 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 1173020002790 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1173020002791 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1173020002792 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1173020002793 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1173020002794 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1173020002795 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1173020002796 Moco binding site; other site 1173020002797 metal coordination site [ion binding]; other site 1173020002798 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1173020002799 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 1173020002800 FAD binding pocket [chemical binding]; other site 1173020002801 FAD binding motif [chemical binding]; other site 1173020002802 phosphate binding motif [ion binding]; other site 1173020002803 beta-alpha-beta structure motif; other site 1173020002804 NAD binding pocket [chemical binding]; other site 1173020002805 Leucine rich repeat; Region: LRR_8; pfam13855 1173020002806 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1173020002807 Helix-turn-helix domain; Region: HTH_17; pfam12728 1173020002808 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 1173020002809 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1173020002810 active site 1173020002811 nucleotide binding site [chemical binding]; other site 1173020002812 HIGH motif; other site 1173020002813 KMSKS motif; other site 1173020002814 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1173020002815 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1173020002816 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 1173020002817 metal ion-dependent adhesion site (MIDAS); other site 1173020002818 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020002819 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1173020002820 active site 1173020002821 DNA binding site [nucleotide binding] 1173020002822 Int/Topo IB signature motif; other site 1173020002823 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020002824 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 1173020002825 Homeodomain-like domain; Region: HTH_23; pfam13384 1173020002826 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1173020002827 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1173020002828 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1173020002829 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 1173020002830 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1173020002831 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173020002832 non-specific DNA binding site [nucleotide binding]; other site 1173020002833 salt bridge; other site 1173020002834 sequence-specific DNA binding site [nucleotide binding]; other site 1173020002835 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1173020002836 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1173020002837 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020002838 active site 1173020002839 DNA binding site [nucleotide binding] 1173020002840 Int/Topo IB signature motif; other site 1173020002841 head completion protein; Provisional; Region: 4; PHA02552 1173020002842 TniQ; Region: TniQ; pfam06527 1173020002843 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1173020002844 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1173020002845 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1173020002846 PLD-like domain; Region: PLDc_2; pfam13091 1173020002847 putative active site [active] 1173020002848 catalytic site [active] 1173020002849 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1173020002850 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020002851 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1173020002852 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1173020002853 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173020002854 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1173020002855 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173020002856 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1173020002857 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173020002858 catalytic core [active] 1173020002859 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173020002860 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 1173020002861 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1173020002862 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1173020002863 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 1173020002864 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1173020002865 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1173020002866 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1173020002867 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1173020002868 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1173020002869 putative ligand binding site [chemical binding]; other site 1173020002870 putative NAD binding site [chemical binding]; other site 1173020002871 catalytic site [active] 1173020002872 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020002873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020002874 active site 1173020002875 phosphorylation site [posttranslational modification] 1173020002876 intermolecular recognition site; other site 1173020002877 dimerization interface [polypeptide binding]; other site 1173020002878 PAS fold; Region: PAS_4; pfam08448 1173020002879 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020002880 putative active site [active] 1173020002881 heme pocket [chemical binding]; other site 1173020002882 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173020002883 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020002884 putative active site [active] 1173020002885 heme pocket [chemical binding]; other site 1173020002886 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1173020002887 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173020002888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020002889 heme pocket [chemical binding]; other site 1173020002890 putative active site [active] 1173020002891 PAS domain; Region: PAS; smart00091 1173020002892 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020002893 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020002894 dimer interface [polypeptide binding]; other site 1173020002895 phosphorylation site [posttranslational modification] 1173020002896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020002897 ATP binding site [chemical binding]; other site 1173020002898 Mg2+ binding site [ion binding]; other site 1173020002899 G-X-G motif; other site 1173020002900 pyruvate kinase; Validated; Region: PRK08187 1173020002901 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1173020002902 domain interfaces; other site 1173020002903 active site 1173020002904 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1173020002905 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 1173020002906 Protein of unknown function DUF262; Region: DUF262; pfam03235 1173020002907 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173020002908 active site 1173020002909 Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622 1173020002910 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1173020002911 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173020002912 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1173020002913 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173020002914 PspC domain; Region: PspC; cl00864 1173020002915 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 1173020002916 Predicted permeases [General function prediction only]; Region: COG0701 1173020002917 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 1173020002918 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1173020002919 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1173020002920 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173020002921 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1173020002922 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020002923 motif II; other site 1173020002924 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1173020002925 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1173020002926 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020002927 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020002928 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020002929 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 1173020002930 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 1173020002931 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1173020002932 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1173020002933 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173020002934 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1173020002935 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020002936 motif II; other site 1173020002937 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1173020002938 PQQ-like domain; Region: PQQ_2; pfam13360 1173020002939 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1173020002940 PQQ-like domain; Region: PQQ_2; pfam13360 1173020002941 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173020002942 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173020002943 Probable transposase; Region: OrfB_IS605; pfam01385 1173020002944 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173020002945 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1173020002946 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1173020002947 DNA binding residues [nucleotide binding] 1173020002948 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1173020002949 catalytic residues [active] 1173020002950 catalytic nucleophile [active] 1173020002951 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1173020002952 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173020002953 sequence-specific DNA binding site [nucleotide binding]; other site 1173020002954 salt bridge; other site 1173020002955 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1173020002956 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1173020002957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020002958 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173020002959 putative substrate translocation pore; other site 1173020002960 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 1173020002961 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1173020002962 active site 1173020002963 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1173020002964 active site 1173020002965 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1173020002966 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173020002967 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1173020002968 BON domain; Region: BON; pfam04972 1173020002969 BON domain; Region: BON; pfam04972 1173020002970 BON domain; Region: BON; pfam04972 1173020002971 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020002972 BON domain; Region: BON; pfam04972 1173020002973 BON domain; Region: BON; pfam04972 1173020002974 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173020002975 catalytic loop [active] 1173020002976 iron binding site [ion binding]; other site 1173020002977 BON domain; Region: BON; pfam04972 1173020002978 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1173020002979 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1173020002980 NAD(P) binding site [chemical binding]; other site 1173020002981 substrate binding site [chemical binding]; other site 1173020002982 dimer interface [polypeptide binding]; other site 1173020002983 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1173020002984 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1173020002985 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1173020002986 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1173020002987 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1173020002988 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1173020002989 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020002990 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1173020002991 active site 1173020002992 metal binding site [ion binding]; metal-binding site 1173020002993 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173020002994 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1173020002995 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1173020002996 potential catalytic triad [active] 1173020002997 conserved cys residue [active] 1173020002998 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1173020002999 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1173020003000 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1173020003001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173020003002 NAD(P) binding site [chemical binding]; other site 1173020003003 active site 1173020003004 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1173020003005 Thioredoxin; Region: Thioredoxin_4; cl17273 1173020003006 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1173020003007 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1173020003008 BON domain; Region: BON; pfam04972 1173020003009 BON domain; Region: BON; pfam04972 1173020003010 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1173020003011 BON domain; Region: BON; pfam04972 1173020003012 BON domain; Region: BON; pfam04972 1173020003013 BON domain; Region: BON; pfam04972 1173020003014 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173020003015 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173020003016 catalytic loop [active] 1173020003017 iron binding site [ion binding]; other site 1173020003018 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1173020003019 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1173020003020 dimerization interface [polypeptide binding]; other site 1173020003021 DPS ferroxidase diiron center [ion binding]; other site 1173020003022 ion pore; other site 1173020003023 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 1173020003024 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1173020003025 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1173020003026 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173020003027 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173020003028 Ligand Binding Site [chemical binding]; other site 1173020003029 T5orf172 domain; Region: T5orf172; cl17462 1173020003030 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1173020003031 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1173020003032 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1173020003033 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173020003034 non-specific DNA binding site [nucleotide binding]; other site 1173020003035 salt bridge; other site 1173020003036 sequence-specific DNA binding site [nucleotide binding]; other site 1173020003037 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1173020003038 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1173020003039 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1173020003040 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1173020003041 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173020003042 ATP binding site [chemical binding]; other site 1173020003043 putative Mg++ binding site [ion binding]; other site 1173020003044 nucleotide binding region [chemical binding]; other site 1173020003045 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 1173020003046 ATP-binding site [chemical binding]; other site 1173020003047 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020003048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020003049 active site 1173020003050 phosphorylation site [posttranslational modification] 1173020003051 intermolecular recognition site; other site 1173020003052 dimerization interface [polypeptide binding]; other site 1173020003053 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020003054 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020003055 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020003056 PAS fold; Region: PAS_3; pfam08447 1173020003057 putative active site [active] 1173020003058 heme pocket [chemical binding]; other site 1173020003059 PAS fold; Region: PAS_4; pfam08448 1173020003060 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020003061 putative active site [active] 1173020003062 heme pocket [chemical binding]; other site 1173020003063 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173020003064 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020003065 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173020003066 putative active site [active] 1173020003067 heme pocket [chemical binding]; other site 1173020003068 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020003069 putative active site [active] 1173020003070 heme pocket [chemical binding]; other site 1173020003071 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020003072 dimer interface [polypeptide binding]; other site 1173020003073 phosphorylation site [posttranslational modification] 1173020003074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020003075 ATP binding site [chemical binding]; other site 1173020003076 Mg2+ binding site [ion binding]; other site 1173020003077 G-X-G motif; other site 1173020003078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020003079 active site 1173020003080 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020003081 phosphorylation site [posttranslational modification] 1173020003082 intermolecular recognition site; other site 1173020003083 dimerization interface [polypeptide binding]; other site 1173020003084 PAS fold; Region: PAS_2; pfam08446 1173020003085 GAF domain; Region: GAF; pfam01590 1173020003086 Phytochrome region; Region: PHY; pfam00360 1173020003087 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020003088 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020003089 dimer interface [polypeptide binding]; other site 1173020003090 phosphorylation site [posttranslational modification] 1173020003091 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173020003092 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173020003093 Probable transposase; Region: OrfB_IS605; pfam01385 1173020003094 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173020003095 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1173020003096 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 1173020003097 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1173020003098 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 1173020003099 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173020003100 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1173020003101 non-specific DNA binding site [nucleotide binding]; other site 1173020003102 salt bridge; other site 1173020003103 sequence-specific DNA binding site [nucleotide binding]; other site 1173020003104 TIGR02687 family protein; Region: TIGR02687 1173020003105 PglZ domain; Region: PglZ; pfam08665 1173020003106 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 1173020003107 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1173020003108 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173020003109 ATP binding site [chemical binding]; other site 1173020003110 putative Mg++ binding site [ion binding]; other site 1173020003111 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173020003112 nucleotide binding region [chemical binding]; other site 1173020003113 ATP-binding site [chemical binding]; other site 1173020003114 Domain of unknown function DUF87; Region: DUF87; pfam01935 1173020003115 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1173020003116 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020003117 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 1173020003118 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1173020003119 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1173020003120 putative active site [active] 1173020003121 Protein of unknown function (DUF433); Region: DUF433; pfam04255 1173020003122 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 1173020003123 AAA ATPase domain; Region: AAA_16; pfam13191 1173020003124 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020003125 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020003126 structural tetrad; other site 1173020003127 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020003128 structural tetrad; other site 1173020003129 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1173020003130 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020003131 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1173020003132 hypothetical protein; Region: PHA01782 1173020003133 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 1173020003134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020003135 putative substrate translocation pore; other site 1173020003136 TPR repeat; Region: TPR_11; pfam13414 1173020003137 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020003138 binding surface 1173020003139 TPR motif; other site 1173020003140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020003141 TPR motif; other site 1173020003142 TPR repeat; Region: TPR_11; pfam13414 1173020003143 binding surface 1173020003144 TPR repeat; Region: TPR_11; pfam13414 1173020003145 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 1173020003146 starch-binding site 2 [chemical binding]; other site 1173020003147 starch-binding site 1 [chemical binding]; other site 1173020003148 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1173020003149 active site 1173020003150 catalytic triad [active] 1173020003151 oxyanion hole [active] 1173020003152 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 1173020003153 malonyl-CoA synthase; Validated; Region: PRK07514 1173020003154 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 1173020003155 acyl-activating enzyme (AAE) consensus motif; other site 1173020003156 active site 1173020003157 AMP binding site [chemical binding]; other site 1173020003158 CoA binding site [chemical binding]; other site 1173020003159 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173020003160 metal binding site [ion binding]; metal-binding site 1173020003161 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1173020003162 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1173020003163 Active Sites [active] 1173020003164 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 1173020003165 phosphoglucomutase; Region: PLN02307 1173020003166 substrate binding site [chemical binding]; other site 1173020003167 dimer interface [polypeptide binding]; other site 1173020003168 active site 1173020003169 metal binding site [ion binding]; metal-binding site 1173020003170 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1173020003171 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 1173020003172 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 1173020003173 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 1173020003174 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 1173020003175 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1173020003176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173020003177 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1173020003178 heterotetramer interface [polypeptide binding]; other site 1173020003179 active site pocket [active] 1173020003180 cleavage site 1173020003181 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 1173020003182 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1173020003183 homotrimer interface [polypeptide binding]; other site 1173020003184 Walker A motif; other site 1173020003185 GTP binding site [chemical binding]; other site 1173020003186 Walker B motif; other site 1173020003187 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1173020003188 active site 1173020003189 catalytic residues [active] 1173020003190 metal binding site [ion binding]; metal-binding site 1173020003191 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1173020003192 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1173020003193 PBS lyase HEAT-like repeat; Region: HEAT_PBS; pfam03130 1173020003194 phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338 1173020003195 Phycobilisome protein; Region: Phycobilisome; cl08227 1173020003196 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 1173020003197 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1173020003198 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 1173020003199 active site 1173020003200 substrate binding site [chemical binding]; other site 1173020003201 metal binding site [ion binding]; metal-binding site 1173020003202 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1173020003203 putative homodimer interface [polypeptide binding]; other site 1173020003204 active site 1173020003205 SAM binding site [chemical binding]; other site 1173020003206 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1173020003207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020003208 S-adenosylmethionine binding site [chemical binding]; other site 1173020003209 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1173020003210 Fasciclin domain; Region: Fasciclin; pfam02469 1173020003211 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 1173020003212 DDE superfamily endonuclease; Region: DDE_5; cl17874 1173020003213 CAAX protease self-immunity; Region: Abi; pfam02517 1173020003214 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1173020003215 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1173020003216 Walker A/P-loop; other site 1173020003217 ATP binding site [chemical binding]; other site 1173020003218 Q-loop/lid; other site 1173020003219 ABC transporter signature motif; other site 1173020003220 Walker B; other site 1173020003221 D-loop; other site 1173020003222 H-loop/switch region; other site 1173020003223 Predicted transcriptional regulator [Transcription]; Region: COG2944 1173020003224 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1173020003225 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020003226 putative active site [active] 1173020003227 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1173020003228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020003229 Walker A/P-loop; other site 1173020003230 ATP binding site [chemical binding]; other site 1173020003231 Q-loop/lid; other site 1173020003232 ABC transporter signature motif; other site 1173020003233 Walker B; other site 1173020003234 D-loop; other site 1173020003235 H-loop/switch region; other site 1173020003236 ABC transporter; Region: ABC_tran_2; pfam12848 1173020003237 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1173020003238 CpeS-like protein; Region: CpeS; pfam09367 1173020003239 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 1173020003240 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020003241 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020003242 DNA binding site [nucleotide binding] 1173020003243 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020003244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020003245 active site 1173020003246 phosphorylation site [posttranslational modification] 1173020003247 intermolecular recognition site; other site 1173020003248 dimerization interface [polypeptide binding]; other site 1173020003249 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020003250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020003251 active site 1173020003252 phosphorylation site [posttranslational modification] 1173020003253 intermolecular recognition site; other site 1173020003254 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1173020003255 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1173020003256 putative dimer interface [polypeptide binding]; other site 1173020003257 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1173020003258 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173020003259 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173020003260 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1173020003261 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1173020003262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173020003263 NAD(P) binding site [chemical binding]; other site 1173020003264 active site 1173020003265 FOG: CBS domain [General function prediction only]; Region: COG0517 1173020003266 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1173020003267 FOG: CBS domain [General function prediction only]; Region: COG0517 1173020003268 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 1173020003269 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1173020003270 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020003271 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173020003272 putative active site [active] 1173020003273 heme pocket [chemical binding]; other site 1173020003274 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020003275 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173020003276 putative active site [active] 1173020003277 heme pocket [chemical binding]; other site 1173020003278 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020003279 putative active site [active] 1173020003280 heme pocket [chemical binding]; other site 1173020003281 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020003282 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1173020003283 putative active site [active] 1173020003284 heme pocket [chemical binding]; other site 1173020003285 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020003286 dimer interface [polypeptide binding]; other site 1173020003287 phosphorylation site [posttranslational modification] 1173020003288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020003289 ATP binding site [chemical binding]; other site 1173020003290 Mg2+ binding site [ion binding]; other site 1173020003291 G-X-G motif; other site 1173020003292 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020003293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020003294 active site 1173020003295 phosphorylation site [posttranslational modification] 1173020003296 intermolecular recognition site; other site 1173020003297 dimerization interface [polypeptide binding]; other site 1173020003298 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173020003299 Ligand Binding Site [chemical binding]; other site 1173020003300 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1173020003301 high affinity sulphate transporter 1; Region: sulP; TIGR00815 1173020003302 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1173020003303 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1173020003304 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173020003305 Ligand Binding Site [chemical binding]; other site 1173020003306 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1173020003307 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1173020003308 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1173020003309 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1173020003310 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1173020003311 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1173020003312 active site 1173020003313 catalytic residues [active] 1173020003314 DNA binding site [nucleotide binding] 1173020003315 Int/Topo IB signature motif; other site 1173020003316 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 1173020003317 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1173020003318 putative active site [active] 1173020003319 catalytic site [active] 1173020003320 Bacterial Ig-like domain (DUF1927); Region: DUF1927; pfam09099 1173020003321 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1173020003322 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173020003323 ATP binding site [chemical binding]; other site 1173020003324 putative Mg++ binding site [ion binding]; other site 1173020003325 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173020003326 nucleotide binding region [chemical binding]; other site 1173020003327 ATP-binding site [chemical binding]; other site 1173020003328 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1173020003329 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 1173020003330 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1173020003331 putative active site [active] 1173020003332 TrwC relaxase; Region: TrwC; pfam08751 1173020003333 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1173020003334 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1173020003335 Mg binding site [ion binding]; other site 1173020003336 nucleotide binding site [chemical binding]; other site 1173020003337 putative protofilament interface [polypeptide binding]; other site 1173020003338 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020003339 structural tetrad; other site 1173020003340 PQQ-like domain; Region: PQQ_2; pfam13360 1173020003341 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1173020003342 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1173020003343 putative active site [active] 1173020003344 putative NTP binding site [chemical binding]; other site 1173020003345 putative nucleic acid binding site [nucleotide binding]; other site 1173020003346 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1173020003347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020003348 S-adenosylmethionine binding site [chemical binding]; other site 1173020003349 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1173020003350 generic binding surface II; other site 1173020003351 generic binding surface I; other site 1173020003352 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020003353 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1173020003354 Transglycosylase; Region: Transgly; cl17702 1173020003355 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1173020003356 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1173020003357 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1173020003358 G1 box; other site 1173020003359 GTP/Mg2+ binding site [chemical binding]; other site 1173020003360 G2 box; other site 1173020003361 Switch I region; other site 1173020003362 G3 box; other site 1173020003363 Switch II region; other site 1173020003364 G4 box; other site 1173020003365 G5 box; other site 1173020003366 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1173020003367 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1173020003368 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1173020003369 dimer interface [polypeptide binding]; other site 1173020003370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020003371 catalytic residue [active] 1173020003372 Predicted metal-dependent protease of the PAD1/JAB1 superfamily [General function prediction only]; Region: COG1310 1173020003373 serine O-acetyltransferase; Region: cysE; TIGR01172 1173020003374 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1173020003375 trimer interface [polypeptide binding]; other site 1173020003376 active site 1173020003377 substrate binding site [chemical binding]; other site 1173020003378 CoA binding site [chemical binding]; other site 1173020003379 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1173020003380 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1173020003381 substrate binding pocket [chemical binding]; other site 1173020003382 membrane-bound complex binding site; other site 1173020003383 hinge residues; other site 1173020003384 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1173020003385 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1173020003386 substrate binding pocket [chemical binding]; other site 1173020003387 membrane-bound complex binding site; other site 1173020003388 hinge residues; other site 1173020003389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020003390 dimer interface [polypeptide binding]; other site 1173020003391 conserved gate region; other site 1173020003392 putative PBP binding loops; other site 1173020003393 ABC-ATPase subunit interface; other site 1173020003394 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020003395 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1173020003396 Walker A/P-loop; other site 1173020003397 ATP binding site [chemical binding]; other site 1173020003398 Q-loop/lid; other site 1173020003399 ABC transporter signature motif; other site 1173020003400 Walker B; other site 1173020003401 D-loop; other site 1173020003402 H-loop/switch region; other site 1173020003403 TIGR04255 family protein; Region: sporadTIGR04255 1173020003404 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173020003405 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173020003406 Probable transposase; Region: OrfB_IS605; pfam01385 1173020003407 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173020003408 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1173020003409 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1173020003410 DNA binding residues [nucleotide binding] 1173020003411 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1173020003412 catalytic residues [active] 1173020003413 catalytic nucleophile [active] 1173020003414 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 1173020003415 PIN domain; Region: PIN_3; pfam13470 1173020003416 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173020003417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020003418 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1173020003419 Walker A motif; other site 1173020003420 ATP binding site [chemical binding]; other site 1173020003421 Walker B motif; other site 1173020003422 arginine finger; other site 1173020003423 AAA-like domain; Region: AAA_10; pfam12846 1173020003424 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1173020003425 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1173020003426 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020003427 AAA-like domain; Region: AAA_10; pfam12846 1173020003428 PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744 1173020003429 putative active site [active] 1173020003430 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1173020003431 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1173020003432 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1173020003433 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 1173020003434 Lipoxygenase; Region: Lipoxygenase; pfam00305 1173020003435 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1173020003436 clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934 1173020003437 NADP binding site [chemical binding]; other site 1173020003438 homotetramer interface [polypeptide binding]; other site 1173020003439 homodimer interface [polypeptide binding]; other site 1173020003440 active site 1173020003441 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1173020003442 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 1173020003443 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1173020003444 Domain of unknown function (DUF389); Region: DUF389; cl00781 1173020003445 Predicted metal binding domain; Region: Metal_CEHH; pfam14455 1173020003446 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173020003447 Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100 1173020003448 Bacteriorhodopsin [General function prediction only]; Region: COG5524 1173020003449 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 1173020003450 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020003451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020003452 active site 1173020003453 phosphorylation site [posttranslational modification] 1173020003454 intermolecular recognition site; other site 1173020003455 dimerization interface [polypeptide binding]; other site 1173020003456 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020003457 DNA binding site [nucleotide binding] 1173020003458 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020003459 dimer interface [polypeptide binding]; other site 1173020003460 phosphorylation site [posttranslational modification] 1173020003461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020003462 ATP binding site [chemical binding]; other site 1173020003463 Mg2+ binding site [ion binding]; other site 1173020003464 G-X-G motif; other site 1173020003465 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1173020003466 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1173020003467 NAD binding site [chemical binding]; other site 1173020003468 homodimer interface [polypeptide binding]; other site 1173020003469 active site 1173020003470 alpha-glucosidase; Provisional; Region: PRK10137 1173020003471 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 1173020003472 Predicted membrane protein [Function unknown]; Region: COG4325 1173020003473 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1173020003474 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1173020003475 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173020003476 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 1173020003477 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173020003478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173020003479 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173020003480 DevC protein; Region: devC; TIGR01185 1173020003481 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1173020003482 FtsX-like permease family; Region: FtsX; pfam02687 1173020003483 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1173020003484 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 1173020003485 Walker A/P-loop; other site 1173020003486 ATP binding site [chemical binding]; other site 1173020003487 Q-loop/lid; other site 1173020003488 ABC transporter signature motif; other site 1173020003489 Walker B; other site 1173020003490 D-loop; other site 1173020003491 H-loop/switch region; other site 1173020003492 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 1173020003493 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173020003494 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1173020003495 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1173020003496 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1173020003497 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1173020003498 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1173020003499 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1173020003500 hypothetical protein; Provisional; Region: PRK06184 1173020003501 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173020003502 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1173020003503 hypothetical protein; Provisional; Region: PRK06184 1173020003504 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1173020003505 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1173020003506 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173020003507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020003508 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173020003509 putative substrate translocation pore; other site 1173020003510 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020003511 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173020003512 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1173020003513 C-terminal domain interface [polypeptide binding]; other site 1173020003514 GSH binding site (G-site) [chemical binding]; other site 1173020003515 dimer interface [polypeptide binding]; other site 1173020003516 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1173020003517 dimer interface [polypeptide binding]; other site 1173020003518 N-terminal domain interface [polypeptide binding]; other site 1173020003519 substrate binding pocket (H-site) [chemical binding]; other site 1173020003520 hypothetical protein; Provisional; Region: PRK06126 1173020003521 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1173020003522 Ferritin-like; Region: Ferritin-like; pfam12902 1173020003523 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1173020003524 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173020003525 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1173020003526 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1173020003527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020003528 catalytic residue [active] 1173020003529 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1173020003530 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1173020003531 substrate binding site [chemical binding]; other site 1173020003532 active site 1173020003533 catalytic residues [active] 1173020003534 heterodimer interface [polypeptide binding]; other site 1173020003535 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1173020003536 active site 1173020003537 ribulose/triose binding site [chemical binding]; other site 1173020003538 phosphate binding site [ion binding]; other site 1173020003539 substrate (anthranilate) binding pocket [chemical binding]; other site 1173020003540 product (indole) binding pocket [chemical binding]; other site 1173020003541 anthranilate synthase; Provisional; Region: PRK13566 1173020003542 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1173020003543 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1173020003544 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1173020003545 glutamine binding [chemical binding]; other site 1173020003546 catalytic triad [active] 1173020003547 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020003548 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173020003549 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020003550 DDE superfamily endonuclease; Region: DDE_5; cl17874 1173020003551 TIGR03118 family protein; Region: PEPCTERM_chp_1 1173020003552 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1173020003553 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173020003554 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020003555 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020003556 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173020003557 Chain length determinant protein; Region: Wzz; pfam02706 1173020003558 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173020003559 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1173020003560 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1173020003561 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1173020003562 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 1173020003563 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173020003564 active site 1173020003565 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020003566 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173020003567 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173020003568 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173020003569 active site 1173020003570 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 1173020003571 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173020003572 active site 1173020003573 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173020003574 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173020003575 active site 1173020003576 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1173020003577 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1173020003578 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173020003579 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173020003580 active site 1173020003581 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1173020003582 trimer interface [polypeptide binding]; other site 1173020003583 active site 1173020003584 substrate binding site [chemical binding]; other site 1173020003585 CoA binding site [chemical binding]; other site 1173020003586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1173020003587 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 1173020003588 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020003589 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1173020003590 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1173020003591 dihydroorotase; Provisional; Region: PRK07575 1173020003592 Amidohydrolase; Region: Amidohydro_5; pfam13594 1173020003593 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 1173020003594 active site 1173020003595 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1173020003596 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020003597 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1173020003598 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1173020003599 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1173020003600 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 1173020003601 active site 1173020003602 interdomain interaction site; other site 1173020003603 putative metal-binding site [ion binding]; other site 1173020003604 nucleotide binding site [chemical binding]; other site 1173020003605 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1173020003606 domain I; other site 1173020003607 phosphate binding site [ion binding]; other site 1173020003608 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1173020003609 domain II; other site 1173020003610 domain III; other site 1173020003611 nucleotide binding site [chemical binding]; other site 1173020003612 DNA binding groove [nucleotide binding] 1173020003613 catalytic site [active] 1173020003614 domain IV; other site 1173020003615 Fic/DOC family; Region: Fic; pfam02661 1173020003616 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 1173020003617 four helix bundle protein; Region: TIGR02436 1173020003618 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020003619 putative active site [active] 1173020003620 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1173020003621 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020003622 active site 1173020003623 DNA binding site [nucleotide binding] 1173020003624 Int/Topo IB signature motif; other site 1173020003625 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 1173020003626 Amino acid permease; Region: AA_permease_2; pfam13520 1173020003627 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173020003628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020003629 S-adenosylmethionine binding site [chemical binding]; other site 1173020003630 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1173020003631 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173020003632 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173020003633 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 1173020003634 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173020003635 catalytic loop [active] 1173020003636 iron binding site [ion binding]; other site 1173020003637 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1173020003638 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1173020003639 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1173020003640 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1173020003641 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1173020003642 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1173020003643 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1173020003644 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1173020003645 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1173020003646 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1173020003647 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1173020003648 metal-binding site 1173020003649 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1173020003650 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1173020003651 heme binding site [chemical binding]; other site 1173020003652 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1173020003653 Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706 1173020003654 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173020003655 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173020003656 Predicted integral membrane protein [Function unknown]; Region: COG5500 1173020003657 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1173020003658 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020003659 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1173020003660 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173020003661 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020003662 Coenzyme A binding pocket [chemical binding]; other site 1173020003663 AAA domain; Region: AAA_33; pfam13671 1173020003664 AAA domain; Region: AAA_17; pfam13207 1173020003665 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020003666 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173020003667 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020003668 MAPEG family; Region: MAPEG; pfam01124 1173020003669 short chain dehydrogenase; Provisional; Region: PRK06500 1173020003670 classical (c) SDRs; Region: SDR_c; cd05233 1173020003671 NAD(P) binding site [chemical binding]; other site 1173020003672 active site 1173020003673 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 1173020003674 Phosphotransferase enzyme family; Region: APH; pfam01636 1173020003675 putative active site [active] 1173020003676 putative substrate binding site [chemical binding]; other site 1173020003677 ATP binding site [chemical binding]; other site 1173020003678 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1173020003679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020003680 Coenzyme A binding pocket [chemical binding]; other site 1173020003681 AAA domain; Region: AAA_17; pfam13207 1173020003682 AAA domain; Region: AAA_33; pfam13671 1173020003683 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1173020003684 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1173020003685 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173020003686 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173020003687 active site 1173020003688 catalytic tetrad [active] 1173020003689 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1173020003690 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173020003691 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1173020003692 dimerization interface [polypeptide binding]; other site 1173020003693 substrate binding pocket [chemical binding]; other site 1173020003694 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1173020003695 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1173020003696 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1173020003697 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1173020003698 Integrase core domain; Region: rve; pfam00665 1173020003699 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020003700 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173020003701 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1173020003702 Mg binding site [ion binding]; other site 1173020003703 nucleotide binding site [chemical binding]; other site 1173020003704 putative protofilament interface [polypeptide binding]; other site 1173020003705 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1173020003706 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173020003707 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173020003708 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1173020003709 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1173020003710 classical (c) SDRs; Region: SDR_c; cd05233 1173020003711 short chain dehydrogenase; Provisional; Region: PRK07041 1173020003712 NAD(P) binding site [chemical binding]; other site 1173020003713 active site 1173020003714 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1173020003715 iron-sulfur cluster [ion binding]; other site 1173020003716 [2Fe-2S] cluster binding site [ion binding]; other site 1173020003717 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1173020003718 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173020003719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020003720 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1173020003721 Walker A motif; other site 1173020003722 ATP binding site [chemical binding]; other site 1173020003723 Walker B motif; other site 1173020003724 arginine finger; other site 1173020003725 AAA-like domain; Region: AAA_10; pfam12846 1173020003726 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173020003727 Walker A motif; other site 1173020003728 ATP binding site [chemical binding]; other site 1173020003729 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1173020003730 Walker B motif; other site 1173020003731 She9 / Mdm33 family; Region: She9_MDM33; pfam05546 1173020003732 AAA-like domain; Region: AAA_10; pfam12846 1173020003733 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1173020003734 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173020003735 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020003736 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173020003737 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020003738 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173020003739 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173020003740 P-loop; other site 1173020003741 Magnesium ion binding site [ion binding]; other site 1173020003742 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173020003743 Magnesium ion binding site [ion binding]; other site 1173020003744 ParB-like nuclease domain; Region: ParB; smart00470 1173020003745 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 1173020003746 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1173020003747 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1173020003748 AAA domain; Region: AAA_30; pfam13604 1173020003749 Family description; Region: UvrD_C_2; pfam13538 1173020003750 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1173020003751 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1173020003752 putative active site [active] 1173020003753 putative NTP binding site [chemical binding]; other site 1173020003754 putative nucleic acid binding site [nucleotide binding]; other site 1173020003755 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1173020003756 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1173020003757 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173020003758 active site 1173020003759 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1173020003760 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 1173020003761 active site 1173020003762 interdomain interaction site; other site 1173020003763 putative metal-binding site [ion binding]; other site 1173020003764 nucleotide binding site [chemical binding]; other site 1173020003765 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1173020003766 domain I; other site 1173020003767 DNA binding groove [nucleotide binding] 1173020003768 phosphate binding site [ion binding]; other site 1173020003769 domain II; other site 1173020003770 domain III; other site 1173020003771 nucleotide binding site [chemical binding]; other site 1173020003772 catalytic site [active] 1173020003773 domain IV; other site 1173020003774 AAA domain; Region: AAA_22; pfam13401 1173020003775 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 1173020003776 Integrase core domain; Region: rve; pfam00665 1173020003777 Integrase core domain; Region: rve_3; cl15866 1173020003778 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1173020003779 Leucine rich repeat; Region: LRR_8; pfam13855 1173020003780 Leucine rich repeat; Region: LRR_8; pfam13855 1173020003781 Leucine rich repeat; Region: LRR_8; pfam13855 1173020003782 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020003783 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1173020003784 active site 1173020003785 DNA binding site [nucleotide binding] 1173020003786 Int/Topo IB signature motif; other site 1173020003787 DDE superfamily endonuclease; Region: DDE_5; cl17874 1173020003788 putative regulator PrlF; Provisional; Region: PRK09974 1173020003789 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1173020003790 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 1173020003791 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1173020003792 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1173020003793 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020003794 active site 1173020003795 Int/Topo IB signature motif; other site 1173020003796 DNA binding site [nucleotide binding] 1173020003797 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1173020003798 putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947 1173020003799 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1173020003800 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020003801 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1173020003802 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1173020003803 active site residue [active] 1173020003804 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1173020003805 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1173020003806 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1173020003807 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1173020003808 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1173020003809 active site residue [active] 1173020003810 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1173020003811 active site residue [active] 1173020003812 Putative phosphatase (DUF442); Region: DUF442; cl17385 1173020003813 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173020003814 dimerization interface [polypeptide binding]; other site 1173020003815 putative DNA binding site [nucleotide binding]; other site 1173020003816 putative Zn2+ binding site [ion binding]; other site 1173020003817 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1173020003818 Sodium Bile acid symporter family; Region: SBF; cl17470 1173020003819 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1173020003820 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1173020003821 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1173020003822 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020003823 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1173020003824 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020003825 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1173020003826 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1173020003827 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1173020003828 DNA binding residues [nucleotide binding] 1173020003829 dimer interface [polypeptide binding]; other site 1173020003830 metal binding site [ion binding]; metal-binding site 1173020003831 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1173020003832 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1173020003833 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1173020003834 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1173020003835 metal-binding site [ion binding] 1173020003836 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173020003837 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173020003838 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1173020003839 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020003840 dimer interface [polypeptide binding]; other site 1173020003841 phosphorylation site [posttranslational modification] 1173020003842 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1173020003843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020003844 ATP binding site [chemical binding]; other site 1173020003845 Mg2+ binding site [ion binding]; other site 1173020003846 G-X-G motif; other site 1173020003847 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020003848 AAA ATPase domain; Region: AAA_16; pfam13191 1173020003849 AAA domain; Region: AAA_22; pfam13401 1173020003850 Walker A motif; other site 1173020003851 ATP binding site [chemical binding]; other site 1173020003852 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 1173020003853 Integrase core domain; Region: rve; pfam00665 1173020003854 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1173020003855 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 1173020003856 substrate binding site [chemical binding]; other site 1173020003857 putative active site [active] 1173020003858 redox center [active] 1173020003859 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1173020003860 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1173020003861 metal-binding site [ion binding] 1173020003862 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173020003863 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173020003864 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173020003865 dimerization interface [polypeptide binding]; other site 1173020003866 putative DNA binding site [nucleotide binding]; other site 1173020003867 putative Zn2+ binding site [ion binding]; other site 1173020003868 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1173020003869 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1173020003870 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173020003871 dimerization interface [polypeptide binding]; other site 1173020003872 putative DNA binding site [nucleotide binding]; other site 1173020003873 putative Zn2+ binding site [ion binding]; other site 1173020003874 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1173020003875 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1173020003876 dimer interface [polypeptide binding]; other site 1173020003877 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1173020003878 catalytic triad [active] 1173020003879 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1173020003880 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1173020003881 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1173020003882 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1173020003883 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1173020003884 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020003885 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020003886 dimer interface [polypeptide binding]; other site 1173020003887 phosphorylation site [posttranslational modification] 1173020003888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020003889 ATP binding site [chemical binding]; other site 1173020003890 Mg2+ binding site [ion binding]; other site 1173020003891 G-X-G motif; other site 1173020003892 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1173020003893 lipoprotein signal peptidase; Provisional; Region: PRK14787 1173020003894 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1173020003895 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1173020003896 putative active site [active] 1173020003897 catalytic triad [active] 1173020003898 putative dimer interface [polypeptide binding]; other site 1173020003899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020003900 S-adenosylmethionine binding site [chemical binding]; other site 1173020003901 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 1173020003902 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1173020003903 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020003904 active site 1173020003905 DNA binding site [nucleotide binding] 1173020003906 Int/Topo IB signature motif; other site 1173020003907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020003908 binding surface 1173020003909 TPR motif; other site 1173020003910 TPR repeat; Region: TPR_11; pfam13414 1173020003911 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020003912 binding surface 1173020003913 TPR motif; other site 1173020003914 TPR repeat; Region: TPR_11; pfam13414 1173020003915 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020003916 TPR motif; other site 1173020003917 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1173020003918 TPR repeat; Region: TPR_11; pfam13414 1173020003919 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020003920 binding surface 1173020003921 TPR motif; other site 1173020003922 TPR repeat; Region: TPR_11; pfam13414 1173020003923 TPR repeat; Region: TPR_11; pfam13414 1173020003924 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cl00234 1173020003925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020003926 S-adenosylmethionine binding site [chemical binding]; other site 1173020003927 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 1173020003928 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1173020003929 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1173020003930 putative active site [active] 1173020003931 putative NTP binding site [chemical binding]; other site 1173020003932 putative nucleic acid binding site [nucleotide binding]; other site 1173020003933 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1173020003934 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1173020003935 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173020003936 active site 1173020003937 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1173020003938 AAA domain; Region: AAA_25; pfam13481 1173020003939 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173020003940 Walker A motif; other site 1173020003941 ATP binding site [chemical binding]; other site 1173020003942 Walker B motif; other site 1173020003943 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020003944 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1173020003945 active site 1173020003946 catalytic residues [active] 1173020003947 DNA binding site [nucleotide binding] 1173020003948 Int/Topo IB signature motif; other site 1173020003949 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1173020003950 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1173020003951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1173020003952 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1173020003953 Integrase core domain; Region: rve; pfam00665 1173020003954 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020003955 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1173020003956 Family description; Region: UvrD_C_2; pfam13538 1173020003957 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1173020003958 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173020003959 ATP binding site [chemical binding]; other site 1173020003960 putative Mg++ binding site [ion binding]; other site 1173020003961 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173020003962 ATP-binding site [chemical binding]; other site 1173020003963 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1173020003964 Protein of unknown function DUF262; Region: DUF262; pfam03235 1173020003965 Uncharacterized conserved protein [Function unknown]; Region: COG4938 1173020003966 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020003967 Walker A/P-loop; other site 1173020003968 ATP binding site [chemical binding]; other site 1173020003969 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 1173020003970 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020003971 putative active site [active] 1173020003972 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020003973 putative active site [active] 1173020003974 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 1173020003975 ERCC4-like helicases [DNA replication, recombination, and repair]; Region: MPH1; COG1111 1173020003976 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173020003977 ATP binding site [chemical binding]; other site 1173020003978 putative Mg++ binding site [ion binding]; other site 1173020003979 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173020003980 nucleotide binding region [chemical binding]; other site 1173020003981 ATP-binding site [chemical binding]; other site 1173020003982 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1173020003983 RES domain; Region: RES; pfam08808 1173020003984 Nuclease-related domain; Region: NERD; pfam08378 1173020003985 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 1173020003986 Part of AAA domain; Region: AAA_19; pfam13245 1173020003987 Family description; Region: UvrD_C_2; pfam13538 1173020003988 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1173020003989 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1173020003990 putative active site [active] 1173020003991 putative NTP binding site [chemical binding]; other site 1173020003992 putative nucleic acid binding site [nucleotide binding]; other site 1173020003993 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1173020003994 Mg binding site [ion binding]; other site 1173020003995 nucleotide binding site [chemical binding]; other site 1173020003996 putative protofilament interface [polypeptide binding]; other site 1173020003997 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1173020003998 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020003999 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1173020004000 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1173020004001 iron-sulfur cluster [ion binding]; other site 1173020004002 [2Fe-2S] cluster binding site [ion binding]; other site 1173020004003 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1173020004004 Leucine rich repeat; Region: LRR_8; pfam13855 1173020004005 Leucine rich repeat; Region: LRR_8; pfam13855 1173020004006 Leucine rich repeat; Region: LRR_8; pfam13855 1173020004007 MobA/MobL family; Region: MobA_MobL; pfam03389 1173020004008 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1173020004009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1173020004010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020004011 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1173020004012 Walker A motif; other site 1173020004013 ATP binding site [chemical binding]; other site 1173020004014 Walker B motif; other site 1173020004015 arginine finger; other site 1173020004016 AAA-like domain; Region: AAA_10; pfam12846 1173020004017 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173020004018 Walker A motif; other site 1173020004019 ATP binding site [chemical binding]; other site 1173020004020 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1173020004021 Walker B motif; other site 1173020004022 AAA-like domain; Region: AAA_10; pfam12846 1173020004023 ParB-like nuclease domain; Region: ParBc; pfam02195 1173020004024 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1173020004025 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173020004026 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173020004027 P-loop; other site 1173020004028 Magnesium ion binding site [ion binding]; other site 1173020004029 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173020004030 Magnesium ion binding site [ion binding]; other site 1173020004031 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 1173020004032 GIY-YIG motif/motif A; other site 1173020004033 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1173020004034 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 1173020004035 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020004036 active site 1173020004037 DNA binding site [nucleotide binding] 1173020004038 Int/Topo IB signature motif; other site 1173020004039 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020004040 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020004041 active site 1173020004042 DNA binding site [nucleotide binding] 1173020004043 Int/Topo IB signature motif; other site 1173020004044 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1173020004045 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020004046 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1173020004047 active site 1173020004048 catalytic residues [active] 1173020004049 DNA binding site [nucleotide binding] 1173020004050 Int/Topo IB signature motif; other site 1173020004051 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1173020004052 AAA domain; Region: AAA_25; pfam13481 1173020004053 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173020004054 Walker A motif; other site 1173020004055 ATP binding site [chemical binding]; other site 1173020004056 Walker B motif; other site 1173020004057 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1173020004058 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1173020004059 putative active site [active] 1173020004060 putative NTP binding site [chemical binding]; other site 1173020004061 putative nucleic acid binding site [nucleotide binding]; other site 1173020004062 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1173020004063 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1173020004064 active site 1173020004065 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1173020004066 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1173020004067 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1173020004068 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020004069 active site 1173020004070 Int/Topo IB signature motif; other site 1173020004071 DNA binding site [nucleotide binding] 1173020004072 T5orf172 domain; Region: T5orf172; cl17462 1173020004073 Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628 1173020004074 5' RNA guide strand anchoring site; other site 1173020004075 active site 1173020004076 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1173020004077 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1173020004078 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173020004079 non-specific DNA binding site [nucleotide binding]; other site 1173020004080 salt bridge; other site 1173020004081 sequence-specific DNA binding site [nucleotide binding]; other site 1173020004082 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1173020004083 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1173020004084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020004085 dimer interface [polypeptide binding]; other site 1173020004086 phosphorylation site [posttranslational modification] 1173020004087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020004088 ATP binding site [chemical binding]; other site 1173020004089 Mg2+ binding site [ion binding]; other site 1173020004090 G-X-G motif; other site 1173020004091 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020004092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020004093 active site 1173020004094 phosphorylation site [posttranslational modification] 1173020004095 intermolecular recognition site; other site 1173020004096 dimerization interface [polypeptide binding]; other site 1173020004097 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020004098 DNA binding site [nucleotide binding] 1173020004099 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1173020004100 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 1173020004101 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1173020004102 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1173020004103 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173020004104 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1173020004105 putative active site [active] 1173020004106 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1173020004107 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1173020004108 Family description; Region: UvrD_C_2; pfam13538 1173020004109 TPR repeat; Region: TPR_11; pfam13414 1173020004110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020004111 binding surface 1173020004112 TPR motif; other site 1173020004113 TPR repeat; Region: TPR_11; pfam13414 1173020004114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020004115 binding surface 1173020004116 TPR motif; other site 1173020004117 TPR repeat; Region: TPR_11; pfam13414 1173020004118 TPR repeat; Region: TPR_11; pfam13414 1173020004119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020004120 binding surface 1173020004121 TPR motif; other site 1173020004122 TPR repeat; Region: TPR_11; pfam13414 1173020004123 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020004124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020004125 active site 1173020004126 phosphorylation site [posttranslational modification] 1173020004127 intermolecular recognition site; other site 1173020004128 dimerization interface [polypeptide binding]; other site 1173020004129 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020004130 DNA binding site [nucleotide binding] 1173020004131 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020004132 dimer interface [polypeptide binding]; other site 1173020004133 phosphorylation site [posttranslational modification] 1173020004134 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1173020004135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020004136 ATP binding site [chemical binding]; other site 1173020004137 Mg2+ binding site [ion binding]; other site 1173020004138 G-X-G motif; other site 1173020004139 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1173020004140 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1173020004141 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1173020004142 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1173020004143 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173020004144 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1173020004145 Protein export membrane protein; Region: SecD_SecF; cl14618 1173020004146 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020004147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020004148 active site 1173020004149 phosphorylation site [posttranslational modification] 1173020004150 intermolecular recognition site; other site 1173020004151 dimerization interface [polypeptide binding]; other site 1173020004152 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020004153 DNA binding site [nucleotide binding] 1173020004154 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020004155 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1173020004156 dimer interface [polypeptide binding]; other site 1173020004157 phosphorylation site [posttranslational modification] 1173020004158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020004159 ATP binding site [chemical binding]; other site 1173020004160 Mg2+ binding site [ion binding]; other site 1173020004161 G-X-G motif; other site 1173020004162 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1173020004163 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1173020004164 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 1173020004165 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173020004166 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1173020004167 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1173020004168 dimer interface [polypeptide binding]; other site 1173020004169 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173020004170 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1173020004171 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173020004172 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 1173020004173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1173020004174 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1173020004175 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1173020004176 Predicted integral membrane protein [Function unknown]; Region: COG5500 1173020004177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173020004178 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1173020004179 NAD(P) binding site [chemical binding]; other site 1173020004180 active site 1173020004181 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1173020004182 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020004183 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173020004184 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020004185 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1173020004186 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1173020004187 DNA binding residues [nucleotide binding] 1173020004188 dimer interface [polypeptide binding]; other site 1173020004189 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1173020004190 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 1173020004191 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1173020004192 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173020004193 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173020004194 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020004195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020004196 active site 1173020004197 phosphorylation site [posttranslational modification] 1173020004198 intermolecular recognition site; other site 1173020004199 dimerization interface [polypeptide binding]; other site 1173020004200 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020004201 DNA binding site [nucleotide binding] 1173020004202 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020004203 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020004204 dimer interface [polypeptide binding]; other site 1173020004205 phosphorylation site [posttranslational modification] 1173020004206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020004207 ATP binding site [chemical binding]; other site 1173020004208 Mg2+ binding site [ion binding]; other site 1173020004209 G-X-G motif; other site 1173020004210 Predicted membrane protein [Function unknown]; Region: COG2149 1173020004211 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1173020004212 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1173020004213 Catalytic site [active] 1173020004214 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1173020004215 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 1173020004216 Integrase core domain; Region: rve; pfam00665 1173020004217 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1173020004218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020004219 AAA domain; Region: AAA_22; pfam13401 1173020004220 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173020004221 Walker A motif; other site 1173020004222 Walker A motif; other site 1173020004223 ATP binding site [chemical binding]; other site 1173020004224 ATP binding site [chemical binding]; other site 1173020004225 Walker B motif; other site 1173020004226 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173020004227 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1173020004228 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1173020004229 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1173020004230 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020004231 motif II; other site 1173020004232 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1173020004233 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1173020004234 Protease prsW family; Region: PrsW-protease; pfam13367 1173020004235 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 1173020004236 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 1173020004237 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1173020004238 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1173020004239 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020004240 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1173020004241 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1173020004242 acyl-activating enzyme (AAE) consensus motif; other site 1173020004243 AMP binding site [chemical binding]; other site 1173020004244 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173020004245 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1173020004246 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1173020004247 putative trimer interface [polypeptide binding]; other site 1173020004248 putative CoA binding site [chemical binding]; other site 1173020004249 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1173020004250 putative trimer interface [polypeptide binding]; other site 1173020004251 putative CoA binding site [chemical binding]; other site 1173020004252 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1173020004253 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1173020004254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1173020004255 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1173020004256 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1173020004257 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1173020004258 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1173020004259 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1173020004260 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 1173020004261 Bacitracin resistance protein BacA; Region: BacA; pfam02673 1173020004262 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1173020004263 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1173020004264 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1173020004265 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1173020004266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020004267 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173020004268 putative substrate translocation pore; other site 1173020004269 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1173020004270 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 1173020004271 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1173020004272 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1173020004273 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1173020004274 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 1173020004275 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1173020004276 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1173020004277 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1173020004278 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 1173020004279 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173020004280 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1173020004281 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1173020004282 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1173020004283 active site 1173020004284 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020004285 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173020004286 Zn(II)-responsive transcriptional regulator; Region: ZntR; TIGR02043 1173020004287 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1173020004288 DNA binding residues [nucleotide binding] 1173020004289 dimer interface [polypeptide binding]; other site 1173020004290 metal binding site [ion binding]; metal-binding site 1173020004291 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020004292 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1173020004293 dimerization interface [polypeptide binding]; other site 1173020004294 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1173020004295 Domain of unknown function (DUF305); Region: DUF305; cl17794 1173020004296 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1173020004297 metal-binding site [ion binding] 1173020004298 flavodoxin FldA; Validated; Region: PRK09267 1173020004299 multicopper oxidase; Provisional; Region: PRK10965 1173020004300 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1173020004301 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1173020004302 Predicted membrane protein [Function unknown]; Region: COG4803 1173020004303 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1173020004304 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1173020004305 metal-binding site [ion binding] 1173020004306 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173020004307 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173020004308 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1173020004309 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1173020004310 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1173020004311 catalytic residue [active] 1173020004312 glutathione reductase; Validated; Region: PRK06116 1173020004313 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173020004314 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173020004315 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1173020004316 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1173020004317 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1173020004318 potential catalytic triad [active] 1173020004319 conserved cys residue [active] 1173020004320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020004321 putative substrate translocation pore; other site 1173020004322 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 1173020004323 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1173020004324 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173020004325 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173020004326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173020004327 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1173020004328 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1173020004329 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1173020004330 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173020004331 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173020004332 DNA binding residues [nucleotide binding] 1173020004333 SnoaL-like domain; Region: SnoaL_2; pfam12680 1173020004334 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1173020004335 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1173020004336 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1173020004337 metal-binding site [ion binding] 1173020004338 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173020004339 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1173020004340 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173020004341 dimerization interface [polypeptide binding]; other site 1173020004342 putative DNA binding site [nucleotide binding]; other site 1173020004343 putative Zn2+ binding site [ion binding]; other site 1173020004344 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173020004345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020004346 S-adenosylmethionine binding site [chemical binding]; other site 1173020004347 manganese transport protein MntH; Reviewed; Region: PRK00701 1173020004348 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1173020004349 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020004350 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1173020004351 active site 1173020004352 DNA binding site [nucleotide binding] 1173020004353 Int/Topo IB signature motif; other site 1173020004354 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1173020004355 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1173020004356 catalytic residues [active] 1173020004357 catalytic nucleophile [active] 1173020004358 Presynaptic Site I dimer interface [polypeptide binding]; other site 1173020004359 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1173020004360 Synaptic Flat tetramer interface [polypeptide binding]; other site 1173020004361 Synaptic Site I dimer interface [polypeptide binding]; other site 1173020004362 DNA binding site [nucleotide binding] 1173020004363 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1173020004364 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1173020004365 Competence protein CoiA-like family; Region: CoiA; cl11541 1173020004366 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 1173020004367 Integrase core domain; Region: rve; pfam00665 1173020004368 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1173020004369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020004370 AAA domain; Region: AAA_22; pfam13401 1173020004371 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173020004372 Walker A motif; other site 1173020004373 Walker A motif; other site 1173020004374 ATP binding site [chemical binding]; other site 1173020004375 ATP binding site [chemical binding]; other site 1173020004376 Walker B motif; other site 1173020004377 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1173020004378 AAA domain; Region: AAA_23; pfam13476 1173020004379 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 1173020004380 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1173020004381 HD domain; Region: HD_4; pfam13328 1173020004382 Protein of unknown function DUF262; Region: DUF262; pfam03235 1173020004383 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 1173020004384 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020004385 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1173020004386 active site 1173020004387 motif I; other site 1173020004388 motif II; other site 1173020004389 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 1173020004390 active site 1173020004391 Zn binding site [ion binding]; other site 1173020004392 ParA-like protein; Provisional; Region: PHA02518 1173020004393 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173020004394 P-loop; other site 1173020004395 Magnesium ion binding site [ion binding]; other site 1173020004396 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1173020004397 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1173020004398 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 1173020004399 Antirestriction protein (ArdA); Region: ArdA; pfam07275 1173020004400 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 1173020004401 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173020004402 non-specific DNA binding site [nucleotide binding]; other site 1173020004403 salt bridge; other site 1173020004404 sequence-specific DNA binding site [nucleotide binding]; other site 1173020004405 AAA ATPase domain; Region: AAA_16; pfam13191 1173020004406 Walker A motif; other site 1173020004407 ATP binding site [chemical binding]; other site 1173020004408 Walker B motif; other site 1173020004409 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1173020004410 structural tetrad; other site 1173020004411 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020004412 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020004413 structural tetrad; other site 1173020004414 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1173020004415 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020004416 active site 1173020004417 DNA binding site [nucleotide binding] 1173020004418 Int/Topo IB signature motif; other site 1173020004419 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1173020004420 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 1173020004421 Domain of unknown function DUF87; Region: DUF87; pfam01935 1173020004422 AAA-like domain; Region: AAA_10; pfam12846 1173020004423 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1173020004424 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 1173020004425 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 1173020004426 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 1173020004427 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 1173020004428 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 1173020004429 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 1173020004430 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1173020004431 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1173020004432 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1173020004433 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1173020004434 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1173020004435 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020004436 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 1173020004437 DDE superfamily endonuclease; Region: DDE_5; cl17874 1173020004438 AAA ATPase domain; Region: AAA_16; pfam13191 1173020004439 AAA domain; Region: AAA_22; pfam13401 1173020004440 Walker A motif; other site 1173020004441 ATP binding site [chemical binding]; other site 1173020004442 Walker B motif; other site 1173020004443 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 1173020004444 Domain of unknown function (DUF927); Region: DUF927; pfam06048 1173020004445 Nuclease-related domain; Region: NERD; pfam08378 1173020004446 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 1173020004447 Part of AAA domain; Region: AAA_19; pfam13245 1173020004448 Family description; Region: UvrD_C_2; pfam13538 1173020004449 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1173020004450 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1173020004451 catalytic residues [active] 1173020004452 catalytic nucleophile [active] 1173020004453 Presynaptic Site I dimer interface [polypeptide binding]; other site 1173020004454 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1173020004455 Synaptic Flat tetramer interface [polypeptide binding]; other site 1173020004456 Synaptic Site I dimer interface [polypeptide binding]; other site 1173020004457 DNA binding site [nucleotide binding] 1173020004458 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1173020004459 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1173020004460 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1173020004461 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020004462 active site 1173020004463 DNA binding site [nucleotide binding] 1173020004464 Int/Topo IB signature motif; other site 1173020004465 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020004466 TPR repeat; Region: TPR_11; pfam13414 1173020004467 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020004468 binding surface 1173020004469 TPR motif; other site 1173020004470 TPR repeat; Region: TPR_11; pfam13414 1173020004471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020004472 binding surface 1173020004473 TPR motif; other site 1173020004474 TPR repeat; Region: TPR_11; pfam13414 1173020004475 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1173020004476 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 1173020004477 pyruvate kinase; Provisional; Region: PRK09206 1173020004478 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173020004479 non-specific DNA binding site [nucleotide binding]; other site 1173020004480 salt bridge; other site 1173020004481 sequence-specific DNA binding site [nucleotide binding]; other site 1173020004482 Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216 1173020004483 IHF - DNA interface [nucleotide binding]; other site 1173020004484 IHF dimer interface [polypeptide binding]; other site 1173020004485 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1173020004486 TPR repeat; Region: TPR_11; pfam13414 1173020004487 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020004488 binding surface 1173020004489 TPR motif; other site 1173020004490 TPR repeat; Region: TPR_11; pfam13414 1173020004491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020004492 S-adenosylmethionine binding site [chemical binding]; other site 1173020004493 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1173020004494 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1173020004495 putative active site [active] 1173020004496 putative NTP binding site [chemical binding]; other site 1173020004497 putative nucleic acid binding site [nucleotide binding]; other site 1173020004498 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1173020004499 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1173020004500 AAA domain; Region: AAA_25; pfam13481 1173020004501 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173020004502 Walker A motif; other site 1173020004503 ATP binding site [chemical binding]; other site 1173020004504 Walker B motif; other site 1173020004505 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1173020004506 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1173020004507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1173020004508 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1173020004509 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020004510 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1173020004511 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173020004512 formamidase; Provisional; Region: amiF; PRK13287 1173020004513 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 1173020004514 multimer interface [polypeptide binding]; other site 1173020004515 active site 1173020004516 catalytic triad [active] 1173020004517 dimer interface [polypeptide binding]; other site 1173020004518 Fe-S metabolism associated domain; Region: SufE; cl00951 1173020004519 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1173020004520 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1173020004521 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1173020004522 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1173020004523 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1173020004524 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1173020004525 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1173020004526 homodecamer interface [polypeptide binding]; other site 1173020004527 GTP cyclohydrolase I; Provisional; Region: PLN03044 1173020004528 active site 1173020004529 putative catalytic site residues [active] 1173020004530 zinc binding site [ion binding]; other site 1173020004531 GTP-CH-I/GFRP interaction surface; other site 1173020004532 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173020004533 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173020004534 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173020004535 murein L,D-transpeptidase; Provisional; Region: PRK10594 1173020004536 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020004537 active site 1173020004538 ATP binding site [chemical binding]; other site 1173020004539 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173020004540 substrate binding site [chemical binding]; other site 1173020004541 substrate binding site [chemical binding]; other site 1173020004542 activation loop (A-loop); other site 1173020004543 activation loop (A-loop); other site 1173020004544 AAA ATPase domain; Region: AAA_16; pfam13191 1173020004545 Predicted ATPase [General function prediction only]; Region: COG3899 1173020004546 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020004547 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020004548 PAS fold; Region: PAS_4; pfam08448 1173020004549 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020004550 putative active site [active] 1173020004551 heme pocket [chemical binding]; other site 1173020004552 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1173020004553 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173020004554 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173020004555 non-specific DNA binding site [nucleotide binding]; other site 1173020004556 salt bridge; other site 1173020004557 sequence-specific DNA binding site [nucleotide binding]; other site 1173020004558 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 1173020004559 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1173020004560 Cytochrome P450; Region: p450; cl12078 1173020004561 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1173020004562 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173020004563 GAF domain; Region: GAF; cl17456 1173020004564 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 1173020004565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1173020004566 active site 1173020004567 phosphorylation site [posttranslational modification] 1173020004568 intermolecular recognition site; other site 1173020004569 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1173020004570 PAS domain S-box; Region: sensory_box; TIGR00229 1173020004571 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020004572 putative active site [active] 1173020004573 heme pocket [chemical binding]; other site 1173020004574 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020004575 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020004576 dimer interface [polypeptide binding]; other site 1173020004577 phosphorylation site [posttranslational modification] 1173020004578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020004579 ATP binding site [chemical binding]; other site 1173020004580 Mg2+ binding site [ion binding]; other site 1173020004581 G-X-G motif; other site 1173020004582 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020004583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020004584 active site 1173020004585 phosphorylation site [posttranslational modification] 1173020004586 intermolecular recognition site; other site 1173020004587 dimerization interface [polypeptide binding]; other site 1173020004588 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020004589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020004590 active site 1173020004591 phosphorylation site [posttranslational modification] 1173020004592 intermolecular recognition site; other site 1173020004593 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020004594 dimer interface [polypeptide binding]; other site 1173020004595 phosphorylation site [posttranslational modification] 1173020004596 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020004597 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020004598 dimer interface [polypeptide binding]; other site 1173020004599 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020004600 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020004601 active site 1173020004602 phosphorylation site [posttranslational modification] 1173020004603 intermolecular recognition site; other site 1173020004604 dimerization interface [polypeptide binding]; other site 1173020004605 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1173020004606 Histidine kinase; Region: HisKA_3; pfam07730 1173020004607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020004608 ATP binding site [chemical binding]; other site 1173020004609 Mg2+ binding site [ion binding]; other site 1173020004610 G-X-G motif; other site 1173020004611 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173020004612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020004613 active site 1173020004614 phosphorylation site [posttranslational modification] 1173020004615 intermolecular recognition site; other site 1173020004616 dimerization interface [polypeptide binding]; other site 1173020004617 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173020004618 DNA binding residues [nucleotide binding] 1173020004619 dimerization interface [polypeptide binding]; other site 1173020004620 NACHT domain; Region: NACHT; pfam05729 1173020004621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1173020004622 HEAT repeats; Region: HEAT_2; pfam13646 1173020004623 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 1173020004624 protein binding surface [polypeptide binding]; other site 1173020004625 HEAT repeats; Region: HEAT_2; pfam13646 1173020004626 HEAT repeats; Region: HEAT_2; pfam13646 1173020004627 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020004628 dimer interface [polypeptide binding]; other site 1173020004629 phosphorylation site [posttranslational modification] 1173020004630 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020004631 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020004632 dimer interface [polypeptide binding]; other site 1173020004633 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020004634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020004635 active site 1173020004636 phosphorylation site [posttranslational modification] 1173020004637 intermolecular recognition site; other site 1173020004638 dimerization interface [polypeptide binding]; other site 1173020004639 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173020004640 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1173020004641 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173020004642 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020004643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020004644 active site 1173020004645 phosphorylation site [posttranslational modification] 1173020004646 intermolecular recognition site; other site 1173020004647 dimerization interface [polypeptide binding]; other site 1173020004648 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020004649 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020004650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020004651 active site 1173020004652 phosphorylation site [posttranslational modification] 1173020004653 intermolecular recognition site; other site 1173020004654 dimerization interface [polypeptide binding]; other site 1173020004655 PAS domain S-box; Region: sensory_box; TIGR00229 1173020004656 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020004657 putative active site [active] 1173020004658 heme pocket [chemical binding]; other site 1173020004659 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020004660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020004661 active site 1173020004662 phosphorylation site [posttranslational modification] 1173020004663 intermolecular recognition site; other site 1173020004664 dimerization interface [polypeptide binding]; other site 1173020004665 glucosamine-fructose-6-phosphate aminotransferase; Provisional; Region: PTZ00295 1173020004666 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1173020004667 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173020004668 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1173020004669 putative effector binding pocket; other site 1173020004670 dimerization interface [polypeptide binding]; other site 1173020004671 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1173020004672 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1173020004673 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1173020004674 NADP binding site [chemical binding]; other site 1173020004675 dimer interface [polypeptide binding]; other site 1173020004676 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1173020004677 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1173020004678 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 1173020004679 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173020004680 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020004681 Coenzyme A binding pocket [chemical binding]; other site 1173020004682 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1173020004683 hypothetical protein; Validated; Region: PRK00029 1173020004684 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1173020004685 Glutaminase; Region: Glutaminase; cl00907 1173020004686 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020004687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020004688 active site 1173020004689 phosphorylation site [posttranslational modification] 1173020004690 intermolecular recognition site; other site 1173020004691 dimerization interface [polypeptide binding]; other site 1173020004692 PAS fold; Region: PAS_3; pfam08447 1173020004693 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020004694 putative active site [active] 1173020004695 heme pocket [chemical binding]; other site 1173020004696 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020004697 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020004698 dimer interface [polypeptide binding]; other site 1173020004699 phosphorylation site [posttranslational modification] 1173020004700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020004701 ATP binding site [chemical binding]; other site 1173020004702 Mg2+ binding site [ion binding]; other site 1173020004703 G-X-G motif; other site 1173020004704 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020004705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020004706 active site 1173020004707 phosphorylation site [posttranslational modification] 1173020004708 intermolecular recognition site; other site 1173020004709 dimerization interface [polypeptide binding]; other site 1173020004710 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020004711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020004712 active site 1173020004713 phosphorylation site [posttranslational modification] 1173020004714 intermolecular recognition site; other site 1173020004715 dimerization interface [polypeptide binding]; other site 1173020004716 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 1173020004717 GAF domain; Region: GAF; pfam01590 1173020004718 Phytochrome region; Region: PHY; pfam00360 1173020004719 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020004720 dimer interface [polypeptide binding]; other site 1173020004721 phosphorylation site [posttranslational modification] 1173020004722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020004723 ATP binding site [chemical binding]; other site 1173020004724 Mg2+ binding site [ion binding]; other site 1173020004725 G-X-G motif; other site 1173020004726 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020004727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020004728 active site 1173020004729 phosphorylation site [posttranslational modification] 1173020004730 intermolecular recognition site; other site 1173020004731 dimerization interface [polypeptide binding]; other site 1173020004732 DinB family; Region: DinB; cl17821 1173020004733 AAA ATPase domain; Region: AAA_16; pfam13191 1173020004734 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020004735 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020004736 structural tetrad; other site 1173020004737 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020004738 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020004739 structural tetrad; other site 1173020004740 Cupin domain; Region: Cupin_2; pfam07883 1173020004741 AAA ATPase domain; Region: AAA_16; pfam13191 1173020004742 NACHT domain; Region: NACHT; pfam05729 1173020004743 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020004744 structural tetrad; other site 1173020004745 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020004746 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020004747 structural tetrad; other site 1173020004748 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020004749 WD40 repeats; Region: WD40; smart00320 1173020004750 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173020004751 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1173020004752 C-terminal domain interface [polypeptide binding]; other site 1173020004753 GSH binding site (G-site) [chemical binding]; other site 1173020004754 dimer interface [polypeptide binding]; other site 1173020004755 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1173020004756 N-terminal domain interface [polypeptide binding]; other site 1173020004757 dimer interface [polypeptide binding]; other site 1173020004758 substrate binding pocket (H-site) [chemical binding]; other site 1173020004759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 1173020004760 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 1173020004761 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173020004762 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1173020004763 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1173020004764 DNA binding residues [nucleotide binding] 1173020004765 putative dimer interface [polypeptide binding]; other site 1173020004766 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1173020004767 Cupin domain; Region: Cupin_2; cl17218 1173020004768 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 1173020004769 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1173020004770 classical (c) SDRs; Region: SDR_c; cd05233 1173020004771 NAD(P) binding site [chemical binding]; other site 1173020004772 active site 1173020004773 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 1173020004774 active site 1 [active] 1173020004775 dimer interface [polypeptide binding]; other site 1173020004776 hexamer interface [polypeptide binding]; other site 1173020004777 active site 2 [active] 1173020004778 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 1173020004779 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1173020004780 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173020004781 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1173020004782 putative effector binding pocket; other site 1173020004783 dimerization interface [polypeptide binding]; other site 1173020004784 topology modulation protein; Reviewed; Region: PRK08118 1173020004785 AAA domain; Region: AAA_17; pfam13207 1173020004786 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 1173020004787 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 1173020004788 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173020004789 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 1173020004790 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1173020004791 N-terminal domain interface [polypeptide binding]; other site 1173020004792 dimer interface [polypeptide binding]; other site 1173020004793 substrate binding pocket (H-site) [chemical binding]; other site 1173020004794 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1173020004795 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1173020004796 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173020004797 DNA binding residues [nucleotide binding] 1173020004798 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 1173020004799 CHAT domain; Region: CHAT; cl17868 1173020004800 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173020004801 CHASE2 domain; Region: CHASE2; pfam05226 1173020004802 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1173020004803 AAA ATPase domain; Region: AAA_16; pfam13191 1173020004804 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020004805 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020004806 structural tetrad; other site 1173020004807 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020004808 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020004809 structural tetrad; other site 1173020004810 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 1173020004811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173020004812 TPR motif; other site 1173020004813 RNA polymerase sigma factor; Provisional; Region: PRK12519 1173020004814 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173020004815 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173020004816 DNA binding residues [nucleotide binding] 1173020004817 putative anti-sigmaE protein; Provisional; Region: PRK13920 1173020004818 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1173020004819 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1173020004820 iron-sulfur cluster [ion binding]; other site 1173020004821 [2Fe-2S] cluster binding site [ion binding]; other site 1173020004822 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173020004823 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173020004824 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1173020004825 Helix-turn-helix domain; Region: HTH_38; pfam13936 1173020004826 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020004827 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1173020004828 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1173020004829 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1173020004830 Ligand Binding Site [chemical binding]; other site 1173020004831 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1173020004832 F subunit of K+-transporting ATPase (Potass_KdpF); Region: Potass_KdpF; pfam09604 1173020004833 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1173020004834 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173020004835 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173020004836 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1173020004837 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020004838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020004839 dimer interface [polypeptide binding]; other site 1173020004840 phosphorylation site [posttranslational modification] 1173020004841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020004842 ATP binding site [chemical binding]; other site 1173020004843 Mg2+ binding site [ion binding]; other site 1173020004844 G-X-G motif; other site 1173020004845 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173020004846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020004847 active site 1173020004848 phosphorylation site [posttranslational modification] 1173020004849 intermolecular recognition site; other site 1173020004850 dimerization interface [polypeptide binding]; other site 1173020004851 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173020004852 DNA binding residues [nucleotide binding] 1173020004853 dimerization interface [polypeptide binding]; other site 1173020004854 short chain dehydrogenase; Provisional; Region: PRK06500 1173020004855 classical (c) SDRs; Region: SDR_c; cd05233 1173020004856 NAD(P) binding site [chemical binding]; other site 1173020004857 active site 1173020004858 MAPEG family; Region: MAPEG; pfam01124 1173020004859 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020004860 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173020004861 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020004862 AAA ATPase domain; Region: AAA_16; pfam13191 1173020004863 NACHT domain; Region: NACHT; pfam05729 1173020004864 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020004865 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020004866 structural tetrad; other site 1173020004867 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020004868 structural tetrad; other site 1173020004869 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020004870 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1173020004871 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173020004872 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1173020004873 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1173020004874 Peptidase C39 family; Region: Peptidase_C39; pfam03412 1173020004875 putative active site [active] 1173020004876 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173020004877 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020004878 Walker A/P-loop; other site 1173020004879 ATP binding site [chemical binding]; other site 1173020004880 Q-loop/lid; other site 1173020004881 ABC transporter signature motif; other site 1173020004882 Walker B; other site 1173020004883 D-loop; other site 1173020004884 H-loop/switch region; other site 1173020004885 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 1173020004886 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 1173020004887 active site 1173020004888 zinc binding site [ion binding]; other site 1173020004889 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 1173020004890 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 1173020004891 active site 1173020004892 zinc binding site [ion binding]; other site 1173020004893 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 1173020004894 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173020004895 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173020004896 DNA binding residues [nucleotide binding] 1173020004897 AAA ATPase domain; Region: AAA_16; pfam13191 1173020004898 NACHT domain; Region: NACHT; pfam05729 1173020004899 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020004900 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020004901 structural tetrad; other site 1173020004902 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020004903 structural tetrad; other site 1173020004904 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020004905 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020004906 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1173020004907 active site 1173020004908 NTP binding site [chemical binding]; other site 1173020004909 metal binding triad [ion binding]; metal-binding site 1173020004910 antibiotic binding site [chemical binding]; other site 1173020004911 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1173020004912 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020004913 Coenzyme A binding pocket [chemical binding]; other site 1173020004914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1173020004915 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1173020004916 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020004917 Coenzyme A binding pocket [chemical binding]; other site 1173020004918 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173020004919 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1173020004920 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173020004921 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1173020004922 active site 1173020004923 metal binding site [ion binding]; metal-binding site 1173020004924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020004925 S-adenosylmethionine binding site [chemical binding]; other site 1173020004926 AAA ATPase domain; Region: AAA_16; pfam13191 1173020004927 NACHT domain; Region: NACHT; pfam05729 1173020004928 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020004929 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020004930 structural tetrad; other site 1173020004931 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020004932 structural tetrad; other site 1173020004933 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020004934 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173020004935 SnoaL-like domain; Region: SnoaL_3; pfam13474 1173020004936 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1173020004937 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020004938 Coenzyme A binding pocket [chemical binding]; other site 1173020004939 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1173020004940 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1173020004941 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 1173020004942 putative active site [active] 1173020004943 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173020004944 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020004945 Walker A/P-loop; other site 1173020004946 ATP binding site [chemical binding]; other site 1173020004947 Q-loop/lid; other site 1173020004948 ABC transporter signature motif; other site 1173020004949 Walker B; other site 1173020004950 D-loop; other site 1173020004951 H-loop/switch region; other site 1173020004952 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1173020004953 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1173020004954 metal ion-dependent adhesion site (MIDAS); other site 1173020004955 RES domain; Region: RES; pfam08808 1173020004956 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 1173020004957 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1173020004958 PemK-like protein; Region: PemK; pfam02452 1173020004959 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1173020004960 DDE superfamily endonuclease; Region: DDE_5; cl17874 1173020004961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1173020004962 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1173020004963 dephospho-CoA kinase; Region: TIGR00152 1173020004964 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1173020004965 CoA-binding site [chemical binding]; other site 1173020004966 hypothetical protein; Provisional; Region: PRK02724 1173020004967 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1173020004968 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1173020004969 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1173020004970 MORN repeat; Region: MORN; cl14787 1173020004971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1173020004972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1173020004973 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1173020004974 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1173020004975 dimer interface [polypeptide binding]; other site 1173020004976 [2Fe-2S] cluster binding site [ion binding]; other site 1173020004977 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1173020004978 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1173020004979 dimerization interface [polypeptide binding]; other site 1173020004980 DPS ferroxidase diiron center [ion binding]; other site 1173020004981 ion pore; other site 1173020004982 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1173020004983 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1173020004984 intersubunit interface [polypeptide binding]; other site 1173020004985 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1173020004986 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173020004987 N-terminal plug; other site 1173020004988 ligand-binding site [chemical binding]; other site 1173020004989 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1173020004990 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1173020004991 Walker A/P-loop; other site 1173020004992 ATP binding site [chemical binding]; other site 1173020004993 Q-loop/lid; other site 1173020004994 ABC transporter signature motif; other site 1173020004995 Walker B; other site 1173020004996 D-loop; other site 1173020004997 H-loop/switch region; other site 1173020004998 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1173020004999 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1173020005000 ABC-ATPase subunit interface; other site 1173020005001 dimer interface [polypeptide binding]; other site 1173020005002 putative PBP binding regions; other site 1173020005003 flavodoxin FldA; Validated; Region: PRK09267 1173020005004 Photosystem II protein; Region: PSII; cl08223 1173020005005 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1173020005006 ABC-ATPase subunit interface; other site 1173020005007 dimer interface [polypeptide binding]; other site 1173020005008 putative PBP binding regions; other site 1173020005009 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 1173020005010 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1173020005011 putative ligand binding site [chemical binding]; other site 1173020005012 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1173020005013 dimer interface [polypeptide binding]; other site 1173020005014 [2Fe-2S] cluster binding site [ion binding]; other site 1173020005015 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1173020005016 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173020005017 N-terminal plug; other site 1173020005018 ligand-binding site [chemical binding]; other site 1173020005019 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1173020005020 dimer interface [polypeptide binding]; other site 1173020005021 [2Fe-2S] cluster binding site [ion binding]; other site 1173020005022 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1173020005023 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173020005024 active site 1173020005025 metal binding site [ion binding]; metal-binding site 1173020005026 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1173020005027 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1173020005028 membrane-bound complex binding site; other site 1173020005029 NosL; Region: NosL; cl01769 1173020005030 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1173020005031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020005032 dimer interface [polypeptide binding]; other site 1173020005033 conserved gate region; other site 1173020005034 putative PBP binding loops; other site 1173020005035 ABC-ATPase subunit interface; other site 1173020005036 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1173020005037 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173020005038 Walker A/P-loop; other site 1173020005039 ATP binding site [chemical binding]; other site 1173020005040 Q-loop/lid; other site 1173020005041 ABC transporter signature motif; other site 1173020005042 Walker B; other site 1173020005043 D-loop; other site 1173020005044 H-loop/switch region; other site 1173020005045 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1173020005046 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173020005047 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1173020005048 dimerization interface [polypeptide binding]; other site 1173020005049 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173020005050 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1173020005051 putative oxidoreductase; Provisional; Region: PRK08275 1173020005052 L-aspartate oxidase; Provisional; Region: PRK06175 1173020005053 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1173020005054 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1173020005055 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1173020005056 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 1173020005057 HEAT repeats; Region: HEAT_2; pfam13646 1173020005058 protein binding surface [polypeptide binding]; other site 1173020005059 HEAT repeats; Region: HEAT_2; pfam13646 1173020005060 HEAT repeats; Region: HEAT_2; pfam13646 1173020005061 antiporter inner membrane protein; Provisional; Region: PRK11670 1173020005062 Domain of unknown function DUF59; Region: DUF59; pfam01883 1173020005063 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1173020005064 Predicted membrane protein [Function unknown]; Region: COG2855 1173020005065 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1173020005066 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1173020005067 ABC-ATPase subunit interface; other site 1173020005068 dimer interface [polypeptide binding]; other site 1173020005069 putative PBP binding regions; other site 1173020005070 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1173020005071 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1173020005072 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1173020005073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020005074 Walker A motif; other site 1173020005075 ATP binding site [chemical binding]; other site 1173020005076 Walker B motif; other site 1173020005077 arginine finger; other site 1173020005078 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1173020005079 activation loop (A-loop); other site 1173020005080 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1173020005081 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020005082 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020005083 structural tetrad; other site 1173020005084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1173020005085 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1173020005086 GTP-binding protein YchF; Reviewed; Region: PRK09601 1173020005087 YchF GTPase; Region: YchF; cd01900 1173020005088 G1 box; other site 1173020005089 GTP/Mg2+ binding site [chemical binding]; other site 1173020005090 Switch I region; other site 1173020005091 G2 box; other site 1173020005092 Switch II region; other site 1173020005093 G3 box; other site 1173020005094 G4 box; other site 1173020005095 G5 box; other site 1173020005096 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1173020005097 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 1173020005098 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 1173020005099 tellurium resistance terB-like protein; Region: terB_like; cd07177 1173020005100 metal binding site [ion binding]; metal-binding site 1173020005101 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 1173020005102 DevC protein; Region: devC; TIGR01185 1173020005103 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1173020005104 FtsX-like permease family; Region: FtsX; pfam02687 1173020005105 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 1173020005106 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173020005107 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173020005108 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173020005109 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173020005110 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655 1173020005111 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 1173020005112 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1173020005113 Walker A/P-loop; other site 1173020005114 ATP binding site [chemical binding]; other site 1173020005115 Q-loop/lid; other site 1173020005116 ABC transporter signature motif; other site 1173020005117 Walker B; other site 1173020005118 D-loop; other site 1173020005119 H-loop/switch region; other site 1173020005120 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 1173020005121 active site 1173020005122 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1173020005123 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173020005124 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173020005125 NMT1-like family; Region: NMT1_2; pfam13379 1173020005126 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1173020005127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020005128 dimer interface [polypeptide binding]; other site 1173020005129 conserved gate region; other site 1173020005130 putative PBP binding loops; other site 1173020005131 ABC-ATPase subunit interface; other site 1173020005132 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173020005133 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1173020005134 Walker A/P-loop; other site 1173020005135 ATP binding site [chemical binding]; other site 1173020005136 Q-loop/lid; other site 1173020005137 ABC transporter signature motif; other site 1173020005138 Walker B; other site 1173020005139 D-loop; other site 1173020005140 H-loop/switch region; other site 1173020005141 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173020005142 NMT1-like family; Region: NMT1_2; pfam13379 1173020005143 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173020005144 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1173020005145 Walker A/P-loop; other site 1173020005146 ATP binding site [chemical binding]; other site 1173020005147 Q-loop/lid; other site 1173020005148 ABC transporter signature motif; other site 1173020005149 Walker B; other site 1173020005150 D-loop; other site 1173020005151 H-loop/switch region; other site 1173020005152 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 1173020005153 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1173020005154 iron-sulfur cluster [ion binding]; other site 1173020005155 [2Fe-2S] cluster binding site [ion binding]; other site 1173020005156 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1173020005157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020005158 putative substrate translocation pore; other site 1173020005159 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173020005160 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020005161 active site 1173020005162 ATP binding site [chemical binding]; other site 1173020005163 substrate binding site [chemical binding]; other site 1173020005164 activation loop (A-loop); other site 1173020005165 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173020005166 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020005167 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020005168 von Willebrand factor; Region: vWF_A; pfam12450 1173020005169 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1173020005170 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 1173020005171 metal ion-dependent adhesion site (MIDAS); other site 1173020005172 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1173020005173 Ycf46; Provisional; Region: ycf46; CHL00195 1173020005174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020005175 Walker A motif; other site 1173020005176 ATP binding site [chemical binding]; other site 1173020005177 Walker B motif; other site 1173020005178 arginine finger; other site 1173020005179 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1173020005180 Peptidase family M48; Region: Peptidase_M48; cl12018 1173020005181 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1173020005182 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1173020005183 RNA polymerase sigma factor; Validated; Region: PRK05949 1173020005184 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1173020005185 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173020005186 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173020005187 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173020005188 DNA binding residues [nucleotide binding] 1173020005189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1173020005190 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020005191 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020005192 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020005193 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020005194 dimer interface [polypeptide binding]; other site 1173020005195 phosphorylation site [posttranslational modification] 1173020005196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020005197 ATP binding site [chemical binding]; other site 1173020005198 Mg2+ binding site [ion binding]; other site 1173020005199 G-X-G motif; other site 1173020005200 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020005201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020005202 active site 1173020005203 phosphorylation site [posttranslational modification] 1173020005204 intermolecular recognition site; other site 1173020005205 dimerization interface [polypeptide binding]; other site 1173020005206 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020005207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020005208 active site 1173020005209 phosphorylation site [posttranslational modification] 1173020005210 intermolecular recognition site; other site 1173020005211 dimerization interface [polypeptide binding]; other site 1173020005212 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1173020005213 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020005214 putative active site [active] 1173020005215 heme pocket [chemical binding]; other site 1173020005216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020005217 dimer interface [polypeptide binding]; other site 1173020005218 phosphorylation site [posttranslational modification] 1173020005219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020005220 ATP binding site [chemical binding]; other site 1173020005221 Mg2+ binding site [ion binding]; other site 1173020005222 G-X-G motif; other site 1173020005223 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020005224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020005225 active site 1173020005226 phosphorylation site [posttranslational modification] 1173020005227 intermolecular recognition site; other site 1173020005228 dimerization interface [polypeptide binding]; other site 1173020005229 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1173020005230 putative active site [active] 1173020005231 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 1173020005232 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173020005233 ATP binding site [chemical binding]; other site 1173020005234 putative Mg++ binding site [ion binding]; other site 1173020005235 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173020005236 nucleotide binding region [chemical binding]; other site 1173020005237 ATP-binding site [chemical binding]; other site 1173020005238 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173020005239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020005240 Walker A/P-loop; other site 1173020005241 ATP binding site [chemical binding]; other site 1173020005242 Q-loop/lid; other site 1173020005243 ABC transporter signature motif; other site 1173020005244 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020005245 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1173020005246 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1173020005247 generic binding surface II; other site 1173020005248 generic binding surface I; other site 1173020005249 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 1173020005250 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1173020005251 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173020005252 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 1173020005253 active site 1173020005254 catalytic tetrad [active] 1173020005255 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 1173020005256 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1173020005257 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173020005258 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173020005259 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020005260 Coenzyme A binding pocket [chemical binding]; other site 1173020005261 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 1173020005262 NlpC/P60 family; Region: NLPC_P60; cl17555 1173020005263 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1173020005264 active site 1173020005265 DNA binding site [nucleotide binding] 1173020005266 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 1173020005267 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020005268 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173020005269 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1173020005270 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173020005271 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173020005272 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173020005273 ligand binding site [chemical binding]; other site 1173020005274 flexible hinge region; other site 1173020005275 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020005276 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 1173020005277 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 1173020005278 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 1173020005279 dimerization interface [polypeptide binding]; other site 1173020005280 putative ATP binding site [chemical binding]; other site 1173020005281 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020005282 Coenzyme A binding pocket [chemical binding]; other site 1173020005283 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 1173020005284 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173020005285 FeS/SAM binding site; other site 1173020005286 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1173020005287 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 1173020005288 putative active site [active] 1173020005289 catalytic triad [active] 1173020005290 putative dimer interface [polypeptide binding]; other site 1173020005291 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 1173020005292 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1173020005293 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173020005294 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173020005295 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173020005296 Probable transposase; Region: OrfB_IS605; pfam01385 1173020005297 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173020005298 Cupin domain; Region: Cupin_2; cl17218 1173020005299 Putative phosphatase (DUF442); Region: DUF442; cl17385 1173020005300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020005301 Coenzyme A binding pocket [chemical binding]; other site 1173020005302 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 1173020005303 diiron binding motif [ion binding]; other site 1173020005304 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1173020005305 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1173020005306 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 1173020005307 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 1173020005308 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1173020005309 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1173020005310 active site 1173020005311 metal binding site [ion binding]; metal-binding site 1173020005312 DNA binding site [nucleotide binding] 1173020005313 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 1173020005314 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173020005315 active site 1173020005316 catalytic tetrad [active] 1173020005317 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 1173020005318 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 1173020005319 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 1173020005320 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1173020005321 catalytic center binding site [active] 1173020005322 ATP binding site [chemical binding]; other site 1173020005323 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1173020005324 dimer interface [polypeptide binding]; other site 1173020005325 ADP-ribose binding site [chemical binding]; other site 1173020005326 active site 1173020005327 nudix motif; other site 1173020005328 metal binding site [ion binding]; metal-binding site 1173020005329 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1173020005330 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1173020005331 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1173020005332 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1173020005333 ThiS interaction site; other site 1173020005334 putative active site [active] 1173020005335 tetramer interface [polypeptide binding]; other site 1173020005336 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173020005337 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173020005338 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173020005339 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173020005340 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173020005341 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173020005342 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173020005343 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1173020005344 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1173020005345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020005346 Walker A motif; other site 1173020005347 ATP binding site [chemical binding]; other site 1173020005348 Walker B motif; other site 1173020005349 arginine finger; other site 1173020005350 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1173020005351 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1173020005352 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1173020005353 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1173020005354 putative active site [active] 1173020005355 catalytic triad [active] 1173020005356 putative dimer interface [polypeptide binding]; other site 1173020005357 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 1173020005358 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173020005359 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173020005360 phosphopeptide binding site; other site 1173020005361 cyclase homology domain; Region: CHD; cd07302 1173020005362 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173020005363 nucleotidyl binding site; other site 1173020005364 metal binding site [ion binding]; metal-binding site 1173020005365 dimer interface [polypeptide binding]; other site 1173020005366 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020005367 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020005368 structural tetrad; other site 1173020005369 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020005370 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020005371 structural tetrad; other site 1173020005372 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020005373 WD40 repeats; Region: WD40; smart00320 1173020005374 Cupin domain; Region: Cupin_2; pfam07883 1173020005375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020005376 Coenzyme A binding pocket [chemical binding]; other site 1173020005377 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1173020005378 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020005379 Coenzyme A binding pocket [chemical binding]; other site 1173020005380 AAA ATPase domain; Region: AAA_16; pfam13191 1173020005381 NACHT domain; Region: NACHT; pfam05729 1173020005382 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020005383 structural tetrad; other site 1173020005384 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020005385 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020005386 structural tetrad; other site 1173020005387 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1173020005388 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173020005389 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173020005390 oxidoreductase; Provisional; Region: PRK06128 1173020005391 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1173020005392 NAD binding site [chemical binding]; other site 1173020005393 metal binding site [ion binding]; metal-binding site 1173020005394 active site 1173020005395 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1173020005396 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173020005397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020005398 S-adenosylmethionine binding site [chemical binding]; other site 1173020005399 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173020005400 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173020005401 catalytic loop [active] 1173020005402 iron binding site [ion binding]; other site 1173020005403 Amino acid permease; Region: AA_permease_2; pfam13520 1173020005404 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173020005405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020005406 S-adenosylmethionine binding site [chemical binding]; other site 1173020005407 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1173020005408 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020005409 motif II; other site 1173020005410 short chain dehydrogenase; Provisional; Region: PRK06181 1173020005411 classical (c) SDRs; Region: SDR_c; cd05233 1173020005412 NAD(P) binding site [chemical binding]; other site 1173020005413 active site 1173020005414 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1173020005415 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1173020005416 NAD binding site [chemical binding]; other site 1173020005417 catalytic Zn binding site [ion binding]; other site 1173020005418 structural Zn binding site [ion binding]; other site 1173020005419 Predicted integral membrane protein [Function unknown]; Region: COG5637 1173020005420 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1173020005421 putative hydrophobic ligand binding site [chemical binding]; other site 1173020005422 short chain dehydrogenase; Provisional; Region: PRK07109 1173020005423 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1173020005424 putative NAD(P) binding site [chemical binding]; other site 1173020005425 active site 1173020005426 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1173020005427 Predicted membrane protein [Function unknown]; Region: COG4244 1173020005428 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 1173020005429 Predicted transcriptional regulators [Transcription]; Region: COG1695 1173020005430 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1173020005431 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1173020005432 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 1173020005433 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1173020005434 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1173020005435 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173020005436 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173020005437 catalytic loop [active] 1173020005438 iron binding site [ion binding]; other site 1173020005439 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020005440 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173020005441 dimerization interface [polypeptide binding]; other site 1173020005442 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020005443 dimer interface [polypeptide binding]; other site 1173020005444 phosphorylation site [posttranslational modification] 1173020005445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020005446 ATP binding site [chemical binding]; other site 1173020005447 Mg2+ binding site [ion binding]; other site 1173020005448 G-X-G motif; other site 1173020005449 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020005450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020005451 active site 1173020005452 phosphorylation site [posttranslational modification] 1173020005453 intermolecular recognition site; other site 1173020005454 dimerization interface [polypeptide binding]; other site 1173020005455 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020005456 DNA binding site [nucleotide binding] 1173020005457 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020005458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020005459 active site 1173020005460 phosphorylation site [posttranslational modification] 1173020005461 intermolecular recognition site; other site 1173020005462 dimerization interface [polypeptide binding]; other site 1173020005463 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1173020005464 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1173020005465 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1173020005466 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1173020005467 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1173020005468 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1173020005469 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173020005470 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1173020005471 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173020005472 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1173020005473 active site 1173020005474 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1173020005475 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173020005476 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173020005477 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1173020005478 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020005479 Walker A/P-loop; other site 1173020005480 ATP binding site [chemical binding]; other site 1173020005481 Q-loop/lid; other site 1173020005482 ABC transporter signature motif; other site 1173020005483 Walker B; other site 1173020005484 D-loop; other site 1173020005485 H-loop/switch region; other site 1173020005486 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173020005487 catalytic core [active] 1173020005488 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173020005489 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173020005490 active site 1173020005491 catalytic tetrad [active] 1173020005492 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173020005493 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1173020005494 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 1173020005495 putative active site [active] 1173020005496 catalytic site [active] 1173020005497 putative metal binding site [ion binding]; other site 1173020005498 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1173020005499 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1173020005500 active site 1173020005501 catalytic site [active] 1173020005502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 1173020005503 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173020005504 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1173020005505 Phytase; Region: Phytase; cl17685 1173020005506 PhoD-like phosphatase; Region: PhoD; pfam09423 1173020005507 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1173020005508 putative active site [active] 1173020005509 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173020005510 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173020005511 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173020005512 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173020005513 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173020005514 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173020005515 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173020005516 active site 1173020005517 metal binding site [ion binding]; metal-binding site 1173020005518 PRC-barrel domain; Region: PRC; pfam05239 1173020005519 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 1173020005520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 1173020005521 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 1173020005522 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 1173020005523 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1173020005524 NADP binding site [chemical binding]; other site 1173020005525 substrate binding site [chemical binding]; other site 1173020005526 active site 1173020005527 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1173020005528 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1173020005529 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1173020005530 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1173020005531 NAD(P) binding site [chemical binding]; other site 1173020005532 substrate binding site [chemical binding]; other site 1173020005533 dimer interface [polypeptide binding]; other site 1173020005534 maltose O-acetyltransferase; Provisional; Region: PRK10092 1173020005535 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1173020005536 active site 1173020005537 substrate binding site [chemical binding]; other site 1173020005538 trimer interface [polypeptide binding]; other site 1173020005539 CoA binding site [chemical binding]; other site 1173020005540 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1173020005541 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1173020005542 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1173020005543 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 1173020005544 ADP-ribose binding site [chemical binding]; other site 1173020005545 Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622 1173020005546 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1173020005547 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1173020005548 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1173020005549 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1173020005550 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1173020005551 ligand binding site [chemical binding]; other site 1173020005552 homodimer interface [polypeptide binding]; other site 1173020005553 NAD(P) binding site [chemical binding]; other site 1173020005554 trimer interface B [polypeptide binding]; other site 1173020005555 trimer interface A [polypeptide binding]; other site 1173020005556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 1173020005557 Protein of unknown function (DUF433); Region: DUF433; pfam04255 1173020005558 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1173020005559 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1173020005560 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1173020005561 motif 1; other site 1173020005562 active site 1173020005563 motif 2; other site 1173020005564 motif 3; other site 1173020005565 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1173020005566 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1173020005567 dimer interface [polypeptide binding]; other site 1173020005568 [2Fe-2S] cluster binding site [ion binding]; other site 1173020005569 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173020005570 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173020005571 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1173020005572 ATP cone domain; Region: ATP-cone; pfam03477 1173020005573 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 1173020005574 photosystem II 47 kDa protein; Region: psbB; CHL00062 1173020005575 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173020005576 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020005577 Coenzyme A binding pocket [chemical binding]; other site 1173020005578 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 1173020005579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020005580 Walker A motif; other site 1173020005581 ATP binding site [chemical binding]; other site 1173020005582 Walker B motif; other site 1173020005583 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 1173020005584 RxxxH motif; other site 1173020005585 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1173020005586 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 1173020005587 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 1173020005588 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1173020005589 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173020005590 dimerization interface [polypeptide binding]; other site 1173020005591 putative DNA binding site [nucleotide binding]; other site 1173020005592 putative Zn2+ binding site [ion binding]; other site 1173020005593 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1173020005594 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1173020005595 FMN binding site [chemical binding]; other site 1173020005596 active site 1173020005597 substrate binding site [chemical binding]; other site 1173020005598 catalytic residue [active] 1173020005599 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1173020005600 DHH family; Region: DHH; pfam01368 1173020005601 DHHA1 domain; Region: DHHA1; pfam02272 1173020005602 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1173020005603 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1173020005604 Walker A/P-loop; other site 1173020005605 ATP binding site [chemical binding]; other site 1173020005606 Q-loop/lid; other site 1173020005607 ABC transporter signature motif; other site 1173020005608 Walker B; other site 1173020005609 D-loop; other site 1173020005610 H-loop/switch region; other site 1173020005611 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 1173020005612 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1173020005613 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1173020005614 RES domain; Region: RES; pfam08808 1173020005615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020005616 dimer interface [polypeptide binding]; other site 1173020005617 conserved gate region; other site 1173020005618 putative PBP binding loops; other site 1173020005619 ABC-ATPase subunit interface; other site 1173020005620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020005621 dimer interface [polypeptide binding]; other site 1173020005622 conserved gate region; other site 1173020005623 putative PBP binding loops; other site 1173020005624 ABC-ATPase subunit interface; other site 1173020005625 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1173020005626 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1173020005627 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1173020005628 substrate binding pocket [chemical binding]; other site 1173020005629 membrane-bound complex binding site; other site 1173020005630 hinge residues; other site 1173020005631 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1173020005632 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173020005633 Walker A/P-loop; other site 1173020005634 ATP binding site [chemical binding]; other site 1173020005635 Q-loop/lid; other site 1173020005636 ABC transporter signature motif; other site 1173020005637 Walker B; other site 1173020005638 D-loop; other site 1173020005639 H-loop/switch region; other site 1173020005640 NMT1/THI5 like; Region: NMT1; pfam09084 1173020005641 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1173020005642 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 1173020005643 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1173020005644 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1173020005645 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1173020005646 UreF; Region: UreF; pfam01730 1173020005647 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727 1173020005648 dimer interface [polypeptide binding]; other site 1173020005649 catalytic residues [active] 1173020005650 UreD urease accessory protein; Region: UreD; pfam01774 1173020005651 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173020005652 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173020005653 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1173020005654 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1173020005655 subunit interactions [polypeptide binding]; other site 1173020005656 active site 1173020005657 flap region; other site 1173020005658 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1173020005659 alpha-beta subunit interface [polypeptide binding]; other site 1173020005660 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1173020005661 alpha-gamma subunit interface [polypeptide binding]; other site 1173020005662 beta-gamma subunit interface [polypeptide binding]; other site 1173020005663 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1173020005664 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1173020005665 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1173020005666 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1173020005667 P-loop, Walker A motif; other site 1173020005668 Base recognition motif; other site 1173020005669 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1173020005670 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 1173020005671 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 1173020005672 nitrile hydratase, alpha subunit; Region: nitrile_alph; TIGR01323 1173020005673 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1173020005674 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1173020005675 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 1173020005676 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 1173020005677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020005678 Walker A/P-loop; other site 1173020005679 ATP binding site [chemical binding]; other site 1173020005680 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1173020005681 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1173020005682 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1173020005683 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 1173020005684 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1173020005685 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1173020005686 malonyl-CoA binding site [chemical binding]; other site 1173020005687 dimer interface [polypeptide binding]; other site 1173020005688 active site 1173020005689 product binding site; other site 1173020005690 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173020005691 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020005692 active site 1173020005693 ATP binding site [chemical binding]; other site 1173020005694 substrate binding site [chemical binding]; other site 1173020005695 activation loop (A-loop); other site 1173020005696 TPR repeat; Region: TPR_11; pfam13414 1173020005697 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 1173020005698 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1173020005699 putative ligand binding site [chemical binding]; other site 1173020005700 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173020005701 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173020005702 phosphopeptide binding site; other site 1173020005703 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 1173020005704 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1173020005705 Walker A/P-loop; other site 1173020005706 ATP binding site [chemical binding]; other site 1173020005707 Q-loop/lid; other site 1173020005708 ABC transporter signature motif; other site 1173020005709 Walker B; other site 1173020005710 D-loop; other site 1173020005711 H-loop/switch region; other site 1173020005712 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1173020005713 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173020005714 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1173020005715 Walker A/P-loop; other site 1173020005716 ATP binding site [chemical binding]; other site 1173020005717 ABC transporter; Region: ABC_tran; pfam00005 1173020005718 Q-loop/lid; other site 1173020005719 ABC transporter signature motif; other site 1173020005720 Walker B; other site 1173020005721 D-loop; other site 1173020005722 H-loop/switch region; other site 1173020005723 glutamate-1-semialdehyde 2,1-aminomutase; Region: PLN02482 1173020005724 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1173020005725 inhibitor-cofactor binding pocket; inhibition site 1173020005726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020005727 catalytic residue [active] 1173020005728 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173020005729 Membrane protein of unknown function; Region: DUF360; pfam04020 1173020005730 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020005731 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020005732 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020005733 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020005734 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1173020005735 ATP-grasp domain; Region: ATP-grasp; pfam02222 1173020005736 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 1173020005737 Ycf35; Provisional; Region: ycf35; CHL00193 1173020005738 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1173020005739 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1173020005740 HAS barrel domain; Region: HAS-barrel; pfam09378 1173020005741 Domain of unknown function DUF87; Region: DUF87; pfam01935 1173020005742 AAA-like domain; Region: AAA_10; pfam12846 1173020005743 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1173020005744 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 1173020005745 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173020005746 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 1173020005747 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1173020005748 Peptidase family M50; Region: Peptidase_M50; pfam02163 1173020005749 active site 1173020005750 putative substrate binding region [chemical binding]; other site 1173020005751 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1173020005752 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1173020005753 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1173020005754 G2 box; other site 1173020005755 Switch I region; other site 1173020005756 G3 box; other site 1173020005757 Switch II region; other site 1173020005758 GTP/Mg2+ binding site [chemical binding]; other site 1173020005759 G4 box; other site 1173020005760 G5 box; other site 1173020005761 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1173020005762 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1173020005763 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 1173020005764 V4R domain; Region: V4R; cl15268 1173020005765 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1173020005766 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1173020005767 TM-ABC transporter signature motif; other site 1173020005768 Transcriptional regulator; Region: Rrf2; cl17282 1173020005769 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1173020005770 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1173020005771 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1173020005772 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1173020005773 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1173020005774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020005775 ATP binding site [chemical binding]; other site 1173020005776 Mg2+ binding site [ion binding]; other site 1173020005777 G-X-G motif; other site 1173020005778 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1173020005779 anchoring element; other site 1173020005780 dimer interface [polypeptide binding]; other site 1173020005781 ATP binding site [chemical binding]; other site 1173020005782 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1173020005783 active site 1173020005784 putative metal-binding site [ion binding]; other site 1173020005785 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1173020005786 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1173020005787 dimer interface [polypeptide binding]; other site 1173020005788 [2Fe-2S] cluster binding site [ion binding]; other site 1173020005789 AMIN domain; Region: AMIN; pfam11741 1173020005790 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173020005791 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173020005792 N-terminal plug; other site 1173020005793 ligand-binding site [chemical binding]; other site 1173020005794 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1173020005795 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1173020005796 dimer interface [polypeptide binding]; other site 1173020005797 putative PBP binding regions; other site 1173020005798 ABC-ATPase subunit interface; other site 1173020005799 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1173020005800 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1173020005801 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1173020005802 ABC-ATPase subunit interface; other site 1173020005803 dimer interface [polypeptide binding]; other site 1173020005804 putative PBP binding regions; other site 1173020005805 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1173020005806 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1173020005807 Walker A/P-loop; other site 1173020005808 ATP binding site [chemical binding]; other site 1173020005809 Q-loop/lid; other site 1173020005810 ABC transporter signature motif; other site 1173020005811 Walker B; other site 1173020005812 D-loop; other site 1173020005813 H-loop/switch region; other site 1173020005814 Protein of unknown function (DUF433); Region: DUF433; pfam04255 1173020005815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 1173020005816 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173020005817 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173020005818 siderophore binding site; other site 1173020005819 Condensation domain; Region: Condensation; pfam00668 1173020005820 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173020005821 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173020005822 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1173020005823 acyl-activating enzyme (AAE) consensus motif; other site 1173020005824 AMP binding site [chemical binding]; other site 1173020005825 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173020005826 Condensation domain; Region: Condensation; pfam00668 1173020005827 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173020005828 Predicted membrane protein [Function unknown]; Region: COG4280 1173020005829 Herpesvirus UL46 protein; Region: Herpes_UL46; cl17368 1173020005830 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1173020005831 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 1173020005832 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1173020005833 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1173020005834 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1173020005835 active site 1173020005836 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1173020005837 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1173020005838 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1173020005839 putative NADP binding site [chemical binding]; other site 1173020005840 active site 1173020005841 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173020005842 Condensation domain; Region: Condensation; pfam00668 1173020005843 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173020005844 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1173020005845 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1173020005846 acyl-activating enzyme (AAE) consensus motif; other site 1173020005847 AMP binding site [chemical binding]; other site 1173020005848 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173020005849 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1173020005850 active site 1173020005851 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1173020005852 H+ Antiporter protein; Region: 2A0121; TIGR00900 1173020005853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020005854 putative substrate translocation pore; other site 1173020005855 salicylate synthase; Region: salicyl_syn; TIGR03494 1173020005856 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1173020005857 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1173020005858 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 1173020005859 acyl-activating enzyme (AAE) consensus motif; other site 1173020005860 AMP binding site [chemical binding]; other site 1173020005861 active site 1173020005862 CoA binding site [chemical binding]; other site 1173020005863 flagellar biosynthesis sigma factor; Provisional; Region: PRK12427 1173020005864 MoxR-like ATPases [General function prediction only]; Region: COG0714 1173020005865 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1173020005866 Protein of unknown function (DUF1838); Region: DUF1838; pfam08894 1173020005867 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1173020005868 Domain of unknown function (DUF4419); Region: DUF4419; pfam14388 1173020005869 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1173020005870 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1173020005871 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1173020005872 Divergent PAP2 family; Region: DUF212; pfam02681 1173020005873 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1173020005874 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1173020005875 substrate binding pocket [chemical binding]; other site 1173020005876 chain length determination region; other site 1173020005877 substrate-Mg2+ binding site; other site 1173020005878 catalytic residues [active] 1173020005879 aspartate-rich region 1; other site 1173020005880 active site lid residues [active] 1173020005881 aspartate-rich region 2; other site 1173020005882 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020005883 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1173020005884 Walker A motif; other site 1173020005885 ATP binding site [chemical binding]; other site 1173020005886 Walker B motif; other site 1173020005887 arginine finger; other site 1173020005888 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 1173020005889 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1173020005890 metal ion-dependent adhesion site (MIDAS); other site 1173020005891 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 1173020005892 Haemolytic domain; Region: Haemolytic; pfam01809 1173020005893 Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350 1173020005894 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1173020005895 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 1173020005896 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 1173020005897 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 1173020005898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173020005899 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1173020005900 Circadian oscillating protein COP23; Region: COP23; pfam14218 1173020005901 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1173020005902 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1173020005903 active site 1173020005904 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1173020005905 5S rRNA interface [nucleotide binding]; other site 1173020005906 CTC domain interface [polypeptide binding]; other site 1173020005907 L16 interface [polypeptide binding]; other site 1173020005908 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1173020005909 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1173020005910 GDP-binding site [chemical binding]; other site 1173020005911 ACT binding site; other site 1173020005912 IMP binding site; other site 1173020005913 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 1173020005914 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1173020005915 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173020005916 FeS/SAM binding site; other site 1173020005917 TRAM domain; Region: TRAM; pfam01938 1173020005918 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020005919 putative active site [active] 1173020005920 calcium/proton exchanger (cax); Region: cax; TIGR00378 1173020005921 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1173020005922 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1173020005923 PBP superfamily domain; Region: PBP_like_2; cl17296 1173020005924 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1173020005925 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 1173020005926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020005927 dimer interface [polypeptide binding]; other site 1173020005928 conserved gate region; other site 1173020005929 putative PBP binding loops; other site 1173020005930 ABC-ATPase subunit interface; other site 1173020005931 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1173020005932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020005933 dimer interface [polypeptide binding]; other site 1173020005934 conserved gate region; other site 1173020005935 putative PBP binding loops; other site 1173020005936 ABC-ATPase subunit interface; other site 1173020005937 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1173020005938 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1173020005939 Walker A/P-loop; other site 1173020005940 ATP binding site [chemical binding]; other site 1173020005941 Q-loop/lid; other site 1173020005942 ABC transporter signature motif; other site 1173020005943 Walker B; other site 1173020005944 D-loop; other site 1173020005945 H-loop/switch region; other site 1173020005946 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173020005947 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173020005948 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1173020005949 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1173020005950 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1173020005951 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 1173020005952 SLBB domain; Region: SLBB; pfam10531 1173020005953 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1173020005954 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1173020005955 trimerization site [polypeptide binding]; other site 1173020005956 active site 1173020005957 Protein of function (DUF2518); Region: DUF2518; pfam10726 1173020005958 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1173020005959 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173020005960 putative catalytic residue [active] 1173020005961 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 1173020005962 Protein of unknown function (DUF790); Region: DUF790; pfam05626 1173020005963 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173020005964 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020005965 DNA polymerase III subunit delta; Validated; Region: PRK07452 1173020005966 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1173020005967 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1173020005968 ligand-binding site [chemical binding]; other site 1173020005969 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1173020005970 active site 1173020005971 ribulose/triose binding site [chemical binding]; other site 1173020005972 phosphate binding site [ion binding]; other site 1173020005973 substrate (anthranilate) binding pocket [chemical binding]; other site 1173020005974 product (indole) binding pocket [chemical binding]; other site 1173020005975 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 1173020005976 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1173020005977 TIGR01777 family protein; Region: yfcH 1173020005978 putative NAD(P) binding site [chemical binding]; other site 1173020005979 gamma-glutamyl kinase; Provisional; Region: PRK05429 1173020005980 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1173020005981 nucleotide binding site [chemical binding]; other site 1173020005982 homotetrameric interface [polypeptide binding]; other site 1173020005983 putative phosphate binding site [ion binding]; other site 1173020005984 putative allosteric binding site; other site 1173020005985 PUA domain; Region: PUA; pfam01472 1173020005986 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1173020005987 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020005988 YceG-like family; Region: YceG; pfam02618 1173020005989 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1173020005990 dimerization interface [polypeptide binding]; other site 1173020005991 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 1173020005992 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1173020005993 RuvA N terminal domain; Region: RuvA_N; pfam01330 1173020005994 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1173020005995 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1173020005996 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 1173020005997 putative ligand binding site [chemical binding]; other site 1173020005998 5-oxoprolinase; Region: PLN02666 1173020005999 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1173020006000 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1173020006001 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1173020006002 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1173020006003 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1173020006004 homotetramer interface [polypeptide binding]; other site 1173020006005 ligand binding site [chemical binding]; other site 1173020006006 catalytic site [active] 1173020006007 NAD binding site [chemical binding]; other site 1173020006008 Integral membrane protein DUF92; Region: DUF92; pfam01940 1173020006009 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 1173020006010 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1173020006011 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1173020006012 nucleotide binding site [chemical binding]; other site 1173020006013 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1173020006014 SBD interface [polypeptide binding]; other site 1173020006015 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1173020006016 oligomeric interface; other site 1173020006017 putative active site [active] 1173020006018 homodimer interface [polypeptide binding]; other site 1173020006019 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 1173020006020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020006021 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173020006022 putative substrate translocation pore; other site 1173020006023 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1173020006024 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1173020006025 substrate binding site [chemical binding]; other site 1173020006026 glutamase interaction surface [polypeptide binding]; other site 1173020006027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020006028 TPR motif; other site 1173020006029 TPR repeat; Region: TPR_11; pfam13414 1173020006030 binding surface 1173020006031 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173020006032 TPR motif; other site 1173020006033 TPR repeat; Region: TPR_11; pfam13414 1173020006034 binding surface 1173020006035 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 1173020006036 Domain of unknown function (DUF1287); Region: DUF1287; pfam06940 1173020006037 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1173020006038 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1173020006039 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173020006040 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1173020006041 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173020006042 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1173020006043 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1173020006044 Predicted membrane protein [Function unknown]; Region: COG1950 1173020006045 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1173020006046 hypothetical protein; Provisional; Region: PRK11281 1173020006047 Predicted membrane protein [Function unknown]; Region: COG2261 1173020006048 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 1173020006049 BON domain; Region: BON; pfam04972 1173020006050 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1173020006051 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1173020006052 light-harvesting-like protein 3; Provisional; Region: PLN00014 1173020006053 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020006054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020006055 active site 1173020006056 phosphorylation site [posttranslational modification] 1173020006057 intermolecular recognition site; other site 1173020006058 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020006059 dimerization interface [polypeptide binding]; other site 1173020006060 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020006061 dimer interface [polypeptide binding]; other site 1173020006062 phosphorylation site [posttranslational modification] 1173020006063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020006064 ATP binding site [chemical binding]; other site 1173020006065 Mg2+ binding site [ion binding]; other site 1173020006066 G-X-G motif; other site 1173020006067 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020006068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020006069 active site 1173020006070 phosphorylation site [posttranslational modification] 1173020006071 intermolecular recognition site; other site 1173020006072 dimerization interface [polypeptide binding]; other site 1173020006073 CHASE3 domain; Region: CHASE3; pfam05227 1173020006074 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020006075 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173020006076 putative active site [active] 1173020006077 heme pocket [chemical binding]; other site 1173020006078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020006079 dimer interface [polypeptide binding]; other site 1173020006080 phosphorylation site [posttranslational modification] 1173020006081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020006082 ATP binding site [chemical binding]; other site 1173020006083 Mg2+ binding site [ion binding]; other site 1173020006084 G-X-G motif; other site 1173020006085 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173020006086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020006087 active site 1173020006088 phosphorylation site [posttranslational modification] 1173020006089 intermolecular recognition site; other site 1173020006090 dimerization interface [polypeptide binding]; other site 1173020006091 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173020006092 DNA binding residues [nucleotide binding] 1173020006093 dimerization interface [polypeptide binding]; other site 1173020006094 putative lipid kinase; Reviewed; Region: PRK00861 1173020006095 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1173020006096 PEGA domain; Region: PEGA; pfam08308 1173020006097 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 1173020006098 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1173020006099 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1173020006100 active site 1173020006101 Na/Ca binding site [ion binding]; other site 1173020006102 catalytic site [active] 1173020006103 S-layer homology domain; Region: SLH; pfam00395 1173020006104 S-layer homology domain; Region: SLH; pfam00395 1173020006105 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1173020006106 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1173020006107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020006108 S-adenosylmethionine binding site [chemical binding]; other site 1173020006109 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1173020006110 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020006111 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020006112 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020006113 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1173020006114 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1173020006115 inhibitor-cofactor binding pocket; inhibition site 1173020006116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020006117 catalytic residue [active] 1173020006118 Type II/IV secretion system protein; Region: T2SE; pfam00437 1173020006119 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173020006120 Walker A motif; other site 1173020006121 ATP binding site [chemical binding]; other site 1173020006122 Walker B motif; other site 1173020006123 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1173020006124 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1173020006125 dimer interface [polypeptide binding]; other site 1173020006126 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1173020006127 PUCC protein; Region: PUCC; pfam03209 1173020006128 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1173020006129 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173020006130 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1173020006131 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 1173020006132 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 1173020006133 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 1173020006134 proton extrusion protein PcxA; Provisional; Region: PRK02507 1173020006135 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1173020006136 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020006137 motif II; other site 1173020006138 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 1173020006139 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1173020006140 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 1173020006141 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1173020006142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1173020006143 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173020006144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020006145 S-adenosylmethionine binding site [chemical binding]; other site 1173020006146 Spherulation-specific family 4; Region: Spherulin4; pfam12138 1173020006147 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020006148 active site 1173020006149 ATP binding site [chemical binding]; other site 1173020006150 substrate binding site [chemical binding]; other site 1173020006151 activation loop (A-loop); other site 1173020006152 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020006153 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020006154 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020006155 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020006156 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020006157 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1173020006158 Glucose inhibited division protein A; Region: GIDA; pfam01134 1173020006159 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173020006160 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173020006161 putative switch regulator; other site 1173020006162 non-specific DNA interactions [nucleotide binding]; other site 1173020006163 DNA binding site [nucleotide binding] 1173020006164 sequence specific DNA binding site [nucleotide binding]; other site 1173020006165 putative cAMP binding site [chemical binding]; other site 1173020006166 FAD binding domain; Region: FAD_binding_4; pfam01565 1173020006167 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1173020006168 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1173020006169 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1173020006170 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1173020006171 TM-ABC transporter signature motif; other site 1173020006172 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1173020006173 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1173020006174 Walker A/P-loop; other site 1173020006175 ATP binding site [chemical binding]; other site 1173020006176 Q-loop/lid; other site 1173020006177 ABC transporter signature motif; other site 1173020006178 Walker B; other site 1173020006179 D-loop; other site 1173020006180 H-loop/switch region; other site 1173020006181 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1173020006182 Resolvase, N terminal domain; Region: Resolvase; smart00857 1173020006183 Recombinase; Region: Recombinase; pfam07508 1173020006184 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1173020006185 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1173020006186 intersubunit interface [polypeptide binding]; other site 1173020006187 active site 1173020006188 zinc binding site [ion binding]; other site 1173020006189 Na+ binding site [ion binding]; other site 1173020006190 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 1173020006191 active site 1173020006192 catalytic residues [active] 1173020006193 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 1173020006194 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173020006195 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173020006196 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173020006197 DNA binding residues [nucleotide binding] 1173020006198 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1173020006199 PGAP1-like protein; Region: PGAP1; pfam07819 1173020006200 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173020006201 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1173020006202 active site 1173020006203 metal binding site [ion binding]; metal-binding site 1173020006204 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173020006205 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1173020006206 HSP70 interaction site [polypeptide binding]; other site 1173020006207 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1173020006208 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1173020006209 dimer interface [polypeptide binding]; other site 1173020006210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020006211 catalytic residue [active] 1173020006212 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020006213 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020006214 structural tetrad; other site 1173020006215 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 1173020006216 metal ion-dependent adhesion site (MIDAS); other site 1173020006217 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 1173020006218 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 1173020006219 G1 box; other site 1173020006220 GTP/Mg2+ binding site [chemical binding]; other site 1173020006221 Switch I region; other site 1173020006222 G2 box; other site 1173020006223 Switch II region; other site 1173020006224 G3 box; other site 1173020006225 G4 box; other site 1173020006226 G5 box; other site 1173020006227 Domain of unknown function (DUF697); Region: DUF697; pfam05128 1173020006228 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1173020006229 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173020006230 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1173020006231 G2 box; other site 1173020006232 Switch I region; other site 1173020006233 G3 box; other site 1173020006234 Switch II region; other site 1173020006235 GTP/Mg2+ binding site [chemical binding]; other site 1173020006236 G4 box; other site 1173020006237 G5 box; other site 1173020006238 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1173020006239 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1173020006240 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 1173020006241 V4R domain; Region: V4R; cl15268 1173020006242 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1173020006243 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 1173020006244 V4R domain; Region: V4R; cl15268 1173020006245 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1173020006246 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1173020006247 Double zinc ribbon; Region: DZR; pfam12773 1173020006248 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1173020006249 active site 1173020006250 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1173020006251 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 1173020006252 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020006253 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173020006254 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020006255 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1173020006256 metal ion-dependent adhesion site (MIDAS); other site 1173020006257 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173020006258 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173020006259 phosphopeptide binding site; other site 1173020006260 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1173020006261 active site 1173020006262 catalytic site [active] 1173020006263 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 1173020006264 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 1173020006265 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1173020006266 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1173020006267 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 1173020006268 hypothetical protein; Provisional; Region: PRK06762 1173020006269 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1173020006270 active site 1173020006271 metal binding site [ion binding]; metal-binding site 1173020006272 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1173020006273 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020006274 motif II; other site 1173020006275 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1173020006276 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1173020006277 active site 1173020006278 iron coordination sites [ion binding]; other site 1173020006279 substrate binding pocket [chemical binding]; other site 1173020006280 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1173020006281 active site 1173020006282 NAD binding site [chemical binding]; other site 1173020006283 metal binding site [ion binding]; metal-binding site 1173020006284 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1173020006285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020006286 S-adenosylmethionine binding site [chemical binding]; other site 1173020006287 hypothetical protein; Provisional; Region: PRK06849 1173020006288 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1173020006289 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173020006290 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1173020006291 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173020006292 Protein kinase domain; Region: Pkinase; pfam00069 1173020006293 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020006294 active site 1173020006295 ATP binding site [chemical binding]; other site 1173020006296 substrate binding site [chemical binding]; other site 1173020006297 activation loop (A-loop); other site 1173020006298 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1173020006299 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1173020006300 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1173020006301 MoaE interaction surface [polypeptide binding]; other site 1173020006302 MoeB interaction surface [polypeptide binding]; other site 1173020006303 thiocarboxylated glycine; other site 1173020006304 threonine synthase; Validated; Region: PRK07591 1173020006305 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1173020006306 homodimer interface [polypeptide binding]; other site 1173020006307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020006308 catalytic residue [active] 1173020006309 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1173020006310 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1173020006311 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1173020006312 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173020006313 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173020006314 active site 1173020006315 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1173020006316 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1173020006317 acyl-activating enzyme (AAE) consensus motif; other site 1173020006318 AMP binding site [chemical binding]; other site 1173020006319 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173020006320 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1173020006321 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1173020006322 active site 1173020006323 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1173020006324 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1173020006325 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173020006326 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1173020006327 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1173020006328 inhibitor-cofactor binding pocket; inhibition site 1173020006329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020006330 catalytic residue [active] 1173020006331 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1173020006332 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173020006333 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1173020006334 acyl-activating enzyme (AAE) consensus motif; other site 1173020006335 AMP binding site [chemical binding]; other site 1173020006336 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173020006337 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1173020006338 O-Antigen ligase; Region: Wzy_C; pfam04932 1173020006339 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1173020006340 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1173020006341 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173020006342 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1173020006343 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173020006344 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020006345 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 1173020006346 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 1173020006347 GDP-Fucose binding site [chemical binding]; other site 1173020006348 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1173020006349 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1173020006350 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173020006351 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1173020006352 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1173020006353 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173020006354 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1173020006355 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1173020006356 Ligand binding site; other site 1173020006357 Putative Catalytic site; other site 1173020006358 DXD motif; other site 1173020006359 Predicted membrane protein [Function unknown]; Region: COG2246 1173020006360 GtrA-like protein; Region: GtrA; pfam04138 1173020006361 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1173020006362 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1173020006363 acetyl-CoA synthetase; Provisional; Region: PRK00174 1173020006364 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1173020006365 active site 1173020006366 CoA binding site [chemical binding]; other site 1173020006367 acyl-activating enzyme (AAE) consensus motif; other site 1173020006368 AMP binding site [chemical binding]; other site 1173020006369 acetate binding site [chemical binding]; other site 1173020006370 Transposase IS200 like; Region: Y1_Tnp; cl00848 1173020006371 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1173020006372 TPP-binding site [chemical binding]; other site 1173020006373 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1173020006374 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1173020006375 PYR/PP interface [polypeptide binding]; other site 1173020006376 dimer interface [polypeptide binding]; other site 1173020006377 TPP binding site [chemical binding]; other site 1173020006378 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1173020006379 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1173020006380 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1173020006381 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1173020006382 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1173020006383 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1173020006384 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173020006385 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 1173020006386 active site 1173020006387 catalytic tetrad [active] 1173020006388 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173020006389 active site 1173020006390 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1173020006391 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1173020006392 RNA binding surface [nucleotide binding]; other site 1173020006393 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1173020006394 allophycocyanin, beta subunit; Region: apcB; TIGR01337 1173020006395 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1173020006396 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1173020006397 trimer interface [polypeptide binding]; other site 1173020006398 putative metal binding site [ion binding]; other site 1173020006399 recombinase A; Provisional; Region: recA; PRK09354 1173020006400 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1173020006401 hexamer interface [polypeptide binding]; other site 1173020006402 Walker A motif; other site 1173020006403 ATP binding site [chemical binding]; other site 1173020006404 Walker B motif; other site 1173020006405 Protein of unknown function (DUF2605); Region: DUF2605; pfam10792 1173020006406 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 1173020006407 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1173020006408 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1173020006409 active site 1173020006410 substrate binding site [chemical binding]; other site 1173020006411 Mg2+ binding site [ion binding]; other site 1173020006412 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173020006413 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1173020006414 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1173020006415 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1173020006416 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1173020006417 Nucleoporin autopeptidase; Region: Nucleoporin2; pfam04096 1173020006418 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173020006419 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020006420 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020006421 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1173020006422 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1173020006423 Walker A/P-loop; other site 1173020006424 ATP binding site [chemical binding]; other site 1173020006425 Q-loop/lid; other site 1173020006426 ABC transporter signature motif; other site 1173020006427 Walker B; other site 1173020006428 D-loop; other site 1173020006429 H-loop/switch region; other site 1173020006430 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1173020006431 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1173020006432 Walker A/P-loop; other site 1173020006433 ATP binding site [chemical binding]; other site 1173020006434 Q-loop/lid; other site 1173020006435 ABC transporter signature motif; other site 1173020006436 Walker B; other site 1173020006437 D-loop; other site 1173020006438 H-loop/switch region; other site 1173020006439 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 1173020006440 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1173020006441 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020006442 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020006443 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020006444 tyrosine phenol-lyase; Provisional; Region: PRK13237 1173020006445 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 1173020006446 substrate binding site [chemical binding]; other site 1173020006447 tetramer interface [polypeptide binding]; other site 1173020006448 catalytic residue [active] 1173020006449 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173020006450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020006451 S-adenosylmethionine binding site [chemical binding]; other site 1173020006452 Biofilm formation and stress response factor; Region: BsmA; cl01794 1173020006453 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1173020006454 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173020006455 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173020006456 catalytic residue [active] 1173020006457 short chain dehydrogenase; Validated; Region: PRK08264 1173020006458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173020006459 NAD(P) binding site [chemical binding]; other site 1173020006460 active site 1173020006461 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1173020006462 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173020006463 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1173020006464 substrate binding pocket [chemical binding]; other site 1173020006465 dimerization interface [polypeptide binding]; other site 1173020006466 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1173020006467 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1173020006468 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1173020006469 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1173020006470 ATP binding site [chemical binding]; other site 1173020006471 Mg++ binding site [ion binding]; other site 1173020006472 motif III; other site 1173020006473 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173020006474 nucleotide binding region [chemical binding]; other site 1173020006475 ATP-binding site [chemical binding]; other site 1173020006476 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1173020006477 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1173020006478 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173020006479 FeS/SAM binding site; other site 1173020006480 Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434 1173020006481 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 1173020006482 substrate binding site [chemical binding]; other site 1173020006483 putative active site [active] 1173020006484 redox center [active] 1173020006485 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173020006486 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173020006487 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1173020006488 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173020006489 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 1173020006490 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1173020006491 thiamine phosphate binding site [chemical binding]; other site 1173020006492 active site 1173020006493 pyrophosphate binding site [ion binding]; other site 1173020006494 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1173020006495 thiS-thiF/thiG interaction site; other site 1173020006496 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1173020006497 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020006498 Coenzyme A binding pocket [chemical binding]; other site 1173020006499 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 1173020006500 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 1173020006501 nudix motif; other site 1173020006502 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1173020006503 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173020006504 HSP70 interaction site [polypeptide binding]; other site 1173020006505 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1173020006506 substrate binding site [polypeptide binding]; other site 1173020006507 dimer interface [polypeptide binding]; other site 1173020006508 molecular chaperone DnaK; Provisional; Region: PRK13410 1173020006509 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1173020006510 nucleotide binding site [chemical binding]; other site 1173020006511 NEF interaction site [polypeptide binding]; other site 1173020006512 SBD interface [polypeptide binding]; other site 1173020006513 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627 1173020006514 putative heme binding site [chemical binding]; other site 1173020006515 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1173020006516 Phosphotransferase enzyme family; Region: APH; pfam01636 1173020006517 active site 1173020006518 substrate binding site [chemical binding]; other site 1173020006519 ATP binding site [chemical binding]; other site 1173020006520 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1173020006521 active site 1173020006522 SAM binding site [chemical binding]; other site 1173020006523 homodimer interface [polypeptide binding]; other site 1173020006524 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1173020006525 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1173020006526 putative active site [active] 1173020006527 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1173020006528 active site 1173020006529 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 1173020006530 dimerization interface [polypeptide binding]; other site 1173020006531 putative active cleft [active] 1173020006532 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020006533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020006534 active site 1173020006535 phosphorylation site [posttranslational modification] 1173020006536 intermolecular recognition site; other site 1173020006537 dimerization interface [polypeptide binding]; other site 1173020006538 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173020006539 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173020006540 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020006541 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1173020006542 intersubunit interface [polypeptide binding]; other site 1173020006543 active site 1173020006544 catalytic residue [active] 1173020006545 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020006546 putative active site [active] 1173020006547 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1173020006548 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1173020006549 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1173020006550 minor groove reading motif; other site 1173020006551 helix-hairpin-helix signature motif; other site 1173020006552 substrate binding pocket [chemical binding]; other site 1173020006553 active site 1173020006554 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1173020006555 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1173020006556 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173020006557 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1173020006558 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1173020006559 [4Fe-4S] binding site [ion binding]; other site 1173020006560 molybdopterin cofactor binding site; other site 1173020006561 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1173020006562 molybdopterin cofactor binding site; other site 1173020006563 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 1173020006564 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1173020006565 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1173020006566 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1173020006567 putative active site [active] 1173020006568 putative substrate binding site [chemical binding]; other site 1173020006569 putative cosubstrate binding site; other site 1173020006570 catalytic site [active] 1173020006571 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1173020006572 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1173020006573 Cytochrome P450; Region: p450; cl12078 1173020006574 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1173020006575 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 1173020006576 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 1173020006577 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 1173020006578 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 1173020006579 Peptidase family M48; Region: Peptidase_M48; pfam01435 1173020006580 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 1173020006581 UbiA prenyltransferase family; Region: UbiA; pfam01040 1173020006582 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1173020006583 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1173020006584 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1173020006585 shikimate binding site; other site 1173020006586 NAD(P) binding site [chemical binding]; other site 1173020006587 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1173020006588 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1173020006589 dimerization interface [polypeptide binding]; other site 1173020006590 DPS ferroxidase diiron center [ion binding]; other site 1173020006591 ion pore; other site 1173020006592 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1173020006593 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 1173020006594 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1173020006595 Ferredoxin [Energy production and conversion]; Region: COG1146 1173020006596 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1173020006597 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 1173020006598 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020006599 binding surface 1173020006600 TPR motif; other site 1173020006601 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 1173020006602 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1173020006603 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1173020006604 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1173020006605 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1173020006606 nudix motif; other site 1173020006607 photosystem I P700 chlorophyll a apoprotein A2; Region: psaB; CHL00054 1173020006608 photosystem I P700 chlorophyll a apoprotein A1; Region: psaA; CHL00056 1173020006609 Fructosamine kinase; Region: Fructosamin_kin; pfam03881 1173020006610 Phosphotransferase enzyme family; Region: APH; pfam01636 1173020006611 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1173020006612 Permease; Region: Permease; cl00510 1173020006613 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 1173020006614 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1173020006615 Substrate binding site; other site 1173020006616 Mg++ binding site; other site 1173020006617 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1173020006618 active site 1173020006619 substrate binding site [chemical binding]; other site 1173020006620 CoA binding site [chemical binding]; other site 1173020006621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020006622 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173020006623 putative substrate translocation pore; other site 1173020006624 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1173020006625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020006626 dimer interface [polypeptide binding]; other site 1173020006627 conserved gate region; other site 1173020006628 ABC-ATPase subunit interface; other site 1173020006629 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 1173020006630 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1173020006631 RNA binding site [nucleotide binding]; other site 1173020006632 active site 1173020006633 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1173020006634 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020006635 Coenzyme A binding pocket [chemical binding]; other site 1173020006636 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1173020006637 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020006638 putative active site [active] 1173020006639 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1173020006640 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1173020006641 oligomer interface [polypeptide binding]; other site 1173020006642 active site residues [active] 1173020006643 Clp protease; Region: CLP_protease; pfam00574 1173020006644 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1173020006645 oligomer interface [polypeptide binding]; other site 1173020006646 active site residues [active] 1173020006647 Clp protease; Region: CLP_protease; pfam00574 1173020006648 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1173020006649 oligomer interface [polypeptide binding]; other site 1173020006650 active site residues [active] 1173020006651 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1173020006652 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1173020006653 RNA binding surface [nucleotide binding]; other site 1173020006654 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1173020006655 active site 1173020006656 Inward rectifier potassium channel; Region: IRK; pfam01007 1173020006657 TPR repeat; Region: TPR_11; pfam13414 1173020006658 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020006659 binding surface 1173020006660 TPR motif; other site 1173020006661 TPR repeat; Region: TPR_11; pfam13414 1173020006662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020006663 binding surface 1173020006664 TPR motif; other site 1173020006665 TPR repeat; Region: TPR_11; pfam13414 1173020006666 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020006667 binding surface 1173020006668 TPR motif; other site 1173020006669 TPR repeat; Region: TPR_11; pfam13414 1173020006670 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020006671 binding surface 1173020006672 TPR motif; other site 1173020006673 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1173020006674 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1173020006675 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 1173020006676 oligomer interface [polypeptide binding]; other site 1173020006677 metal binding site [ion binding]; metal-binding site 1173020006678 metal binding site [ion binding]; metal-binding site 1173020006679 Cl binding site [ion binding]; other site 1173020006680 aspartate ring; other site 1173020006681 basic sphincter; other site 1173020006682 putative hydrophobic gate; other site 1173020006683 periplasmic entrance; other site 1173020006684 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1173020006685 Predicted membrane protein [Function unknown]; Region: COG2510 1173020006686 Domain of unknown function (DUF362); Region: DUF362; pfam04015 1173020006687 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1173020006688 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1173020006689 active site 1173020006690 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1173020006691 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173020006692 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1173020006693 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1173020006694 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1173020006695 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1173020006696 Iron permease FTR1 family; Region: FTR1; cl00475 1173020006697 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 1173020006698 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 1173020006699 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 1173020006700 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1173020006701 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173020006702 HSP70 interaction site [polypeptide binding]; other site 1173020006703 GUN4-like; Region: GUN4; pfam05419 1173020006704 GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450 1173020006705 GIY-YIG motif/motif A; other site 1173020006706 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 1173020006707 GTPase RsgA; Reviewed; Region: PRK12289 1173020006708 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1173020006709 RNA binding site [nucleotide binding]; other site 1173020006710 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1173020006711 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1173020006712 GTP/Mg2+ binding site [chemical binding]; other site 1173020006713 G4 box; other site 1173020006714 G5 box; other site 1173020006715 G1 box; other site 1173020006716 Switch I region; other site 1173020006717 G2 box; other site 1173020006718 G3 box; other site 1173020006719 Switch II region; other site 1173020006720 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173020006721 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173020006722 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 1173020006723 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173020006724 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173020006725 DevC protein; Region: devC; TIGR01185 1173020006726 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1173020006727 FtsX-like permease family; Region: FtsX; pfam02687 1173020006728 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 1173020006729 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1173020006730 Walker A/P-loop; other site 1173020006731 ATP binding site [chemical binding]; other site 1173020006732 Q-loop/lid; other site 1173020006733 ABC transporter signature motif; other site 1173020006734 Walker B; other site 1173020006735 D-loop; other site 1173020006736 H-loop/switch region; other site 1173020006737 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1173020006738 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1173020006739 iron-sulfur cluster [ion binding]; other site 1173020006740 [2Fe-2S] cluster binding site [ion binding]; other site 1173020006741 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1173020006742 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 1173020006743 Protein of unknown function (DUF512); Region: DUF512; pfam04459 1173020006744 Outer membrane efflux protein; Region: OEP; pfam02321 1173020006745 Outer membrane efflux protein; Region: OEP; pfam02321 1173020006746 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173020006747 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173020006748 catalytic loop [active] 1173020006749 iron binding site [ion binding]; other site 1173020006750 photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989 1173020006751 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1173020006752 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1173020006753 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1173020006754 substrate binding site [chemical binding]; other site 1173020006755 hexamer interface [polypeptide binding]; other site 1173020006756 metal binding site [ion binding]; metal-binding site 1173020006757 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 1173020006758 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173020006759 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173020006760 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; pfam01036 1173020006761 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 1173020006762 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 1173020006763 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1173020006764 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1173020006765 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1173020006766 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1173020006767 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1173020006768 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1173020006769 DNA binding site [nucleotide binding] 1173020006770 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1173020006771 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 1173020006772 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1173020006773 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1173020006774 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1173020006775 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1173020006776 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1173020006777 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1173020006778 RPB1 interaction site [polypeptide binding]; other site 1173020006779 RPB10 interaction site [polypeptide binding]; other site 1173020006780 RPB11 interaction site [polypeptide binding]; other site 1173020006781 RPB3 interaction site [polypeptide binding]; other site 1173020006782 RPB12 interaction site [polypeptide binding]; other site 1173020006783 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1173020006784 active site 1173020006785 ribosomal protein S20; Region: rps20; CHL00102 1173020006786 TPR repeat; Region: TPR_11; pfam13414 1173020006787 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020006788 binding surface 1173020006789 TPR motif; other site 1173020006790 TPR repeat; Region: TPR_11; pfam13414 1173020006791 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020006792 binding surface 1173020006793 TPR motif; other site 1173020006794 TPR repeat; Region: TPR_11; pfam13414 1173020006795 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173020006796 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020006797 active site 1173020006798 ATP binding site [chemical binding]; other site 1173020006799 substrate binding site [chemical binding]; other site 1173020006800 activation loop (A-loop); other site 1173020006801 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1173020006802 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 1173020006803 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020006804 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020006805 DNA primase, catalytic core; Region: dnaG; TIGR01391 1173020006806 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1173020006807 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1173020006808 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1173020006809 active site 1173020006810 metal binding site [ion binding]; metal-binding site 1173020006811 interdomain interaction site; other site 1173020006812 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1173020006813 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173020006814 active site 1173020006815 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 1173020006816 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1173020006817 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1173020006818 HEAT repeats; Region: HEAT_2; pfam13646 1173020006819 HEAT repeats; Region: HEAT_2; pfam13646 1173020006820 HEAT repeats; Region: HEAT_2; pfam13646 1173020006821 HEAT repeats; Region: HEAT_2; pfam13646 1173020006822 S-layer homology domain; Region: SLH; pfam00395 1173020006823 S-layer homology domain; Region: SLH; pfam00395 1173020006824 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1173020006825 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173020006826 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173020006827 ligand binding site [chemical binding]; other site 1173020006828 flexible hinge region; other site 1173020006829 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1173020006830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020006831 Walker A motif; other site 1173020006832 ATP binding site [chemical binding]; other site 1173020006833 Walker B motif; other site 1173020006834 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 1173020006835 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1173020006836 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173020006837 catalytic loop [active] 1173020006838 iron binding site [ion binding]; other site 1173020006839 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173020006840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020006841 S-adenosylmethionine binding site [chemical binding]; other site 1173020006842 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 1173020006843 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1173020006844 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1173020006845 ATP-sulfurylase; Region: ATPS; cd00517 1173020006846 active site 1173020006847 HXXH motif; other site 1173020006848 flexible loop; other site 1173020006849 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1173020006850 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1173020006851 Ligand Binding Site [chemical binding]; other site 1173020006852 Molecular Tunnel; other site 1173020006853 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1173020006854 generic binding surface II; other site 1173020006855 generic binding surface I; other site 1173020006856 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 1173020006857 putative active site [active] 1173020006858 putative catalytic site [active] 1173020006859 putative Mg binding site IVb [ion binding]; other site 1173020006860 putative phosphate binding site [ion binding]; other site 1173020006861 putative DNA binding site [nucleotide binding]; other site 1173020006862 putative Mg binding site IVa [ion binding]; other site 1173020006863 TrkA-N domain; Region: TrkA_N; pfam02254 1173020006864 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173020006865 TrkA-N domain; Region: TrkA_N; pfam02254 1173020006866 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1173020006867 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173020006868 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1173020006869 SdiA-regulated; Region: SdiA-regulated; cd09971 1173020006870 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1173020006871 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 1173020006872 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1173020006873 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1173020006874 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1173020006875 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 1173020006876 putative active site [active] 1173020006877 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173020006878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020006879 Walker A/P-loop; other site 1173020006880 ATP binding site [chemical binding]; other site 1173020006881 Q-loop/lid; other site 1173020006882 ABC transporter signature motif; other site 1173020006883 Walker B; other site 1173020006884 D-loop; other site 1173020006885 H-loop/switch region; other site 1173020006886 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 1173020006887 Predicted transcriptional regulators [Transcription]; Region: COG1733 1173020006888 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1173020006889 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1173020006890 active site 1173020006891 HEAT repeats; Region: HEAT_2; pfam13646 1173020006892 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 1173020006893 protein binding surface [polypeptide binding]; other site 1173020006894 HEAT repeats; Region: HEAT_2; pfam13646 1173020006895 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 1173020006896 protein binding surface [polypeptide binding]; other site 1173020006897 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 1173020006898 HEAT repeats; Region: HEAT_2; pfam13646 1173020006899 protein binding surface [polypeptide binding]; other site 1173020006900 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 1173020006901 HEAT repeats; Region: HEAT_2; pfam13646 1173020006902 protein binding surface [polypeptide binding]; other site 1173020006903 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 1173020006904 Cytochrome P450; Region: p450; cl12078 1173020006905 PQQ-like domain; Region: PQQ_2; pfam13360 1173020006906 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1173020006907 Trp docking motif [polypeptide binding]; other site 1173020006908 active site 1173020006909 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1173020006910 Trp docking motif [polypeptide binding]; other site 1173020006911 active site 1173020006912 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 1173020006913 Cytochrome P450; Region: p450; cl12078 1173020006914 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1173020006915 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020006916 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173020006917 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173020006918 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1173020006919 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1173020006920 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1173020006921 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020006922 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1173020006923 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173020006924 active site 1173020006925 metal binding site [ion binding]; metal-binding site 1173020006926 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1173020006927 active site 1173020006928 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 1173020006929 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020006930 GAF domain; Region: GAF; pfam01590 1173020006931 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020006932 dimer interface [polypeptide binding]; other site 1173020006933 phosphorylation site [posttranslational modification] 1173020006934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020006935 ATP binding site [chemical binding]; other site 1173020006936 Mg2+ binding site [ion binding]; other site 1173020006937 G-X-G motif; other site 1173020006938 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1173020006939 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173020006940 N-terminal plug; other site 1173020006941 ligand-binding site [chemical binding]; other site 1173020006942 Predicted transcriptional regulator [Transcription]; Region: COG3682 1173020006943 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1173020006944 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173020006945 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 1173020006946 Ion transport protein; Region: Ion_trans; pfam00520 1173020006947 Ion channel; Region: Ion_trans_2; pfam07885 1173020006948 Double zinc ribbon; Region: DZR; pfam12773 1173020006949 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1173020006950 Transposase domain (DUF772); Region: DUF772; pfam05598 1173020006951 adenylosuccinate lyase; Provisional; Region: PRK07380 1173020006952 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1173020006953 tetramer interface [polypeptide binding]; other site 1173020006954 active site 1173020006955 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1173020006956 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1173020006957 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1173020006958 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1173020006959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020006960 dimer interface [polypeptide binding]; other site 1173020006961 conserved gate region; other site 1173020006962 putative PBP binding loops; other site 1173020006963 ABC-ATPase subunit interface; other site 1173020006964 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1173020006965 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1173020006966 E3 interaction surface; other site 1173020006967 lipoyl attachment site [posttranslational modification]; other site 1173020006968 e3 binding domain; Region: E3_binding; pfam02817 1173020006969 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1173020006970 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1173020006971 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1173020006972 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1173020006973 acyl-activating enzyme (AAE) consensus motif; other site 1173020006974 putative AMP binding site [chemical binding]; other site 1173020006975 putative active site [active] 1173020006976 putative CoA binding site [chemical binding]; other site 1173020006977 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173020006978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020006979 Walker A/P-loop; other site 1173020006980 ATP binding site [chemical binding]; other site 1173020006981 Q-loop/lid; other site 1173020006982 ABC transporter signature motif; other site 1173020006983 Walker B; other site 1173020006984 D-loop; other site 1173020006985 H-loop/switch region; other site 1173020006986 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1173020006987 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1173020006988 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173020006989 ATP binding site [chemical binding]; other site 1173020006990 putative Mg++ binding site [ion binding]; other site 1173020006991 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173020006992 nucleotide binding region [chemical binding]; other site 1173020006993 ATP-binding site [chemical binding]; other site 1173020006994 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1173020006995 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 1173020006996 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1173020006997 Walker A/P-loop; other site 1173020006998 ATP binding site [chemical binding]; other site 1173020006999 Q-loop/lid; other site 1173020007000 ABC transporter signature motif; other site 1173020007001 Walker B; other site 1173020007002 D-loop; other site 1173020007003 H-loop/switch region; other site 1173020007004 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1173020007005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020007006 dimer interface [polypeptide binding]; other site 1173020007007 conserved gate region; other site 1173020007008 putative PBP binding loops; other site 1173020007009 ABC-ATPase subunit interface; other site 1173020007010 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1173020007011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020007012 dimer interface [polypeptide binding]; other site 1173020007013 conserved gate region; other site 1173020007014 putative PBP binding loops; other site 1173020007015 ABC-ATPase subunit interface; other site 1173020007016 PBP superfamily domain; Region: PBP_like_2; cl17296 1173020007017 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 1173020007018 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1173020007019 triosephosphate isomerase; Provisional; Region: PRK14565 1173020007020 substrate binding site [chemical binding]; other site 1173020007021 dimer interface [polypeptide binding]; other site 1173020007022 catalytic triad [active] 1173020007023 Protein of unknown function (DUF3422); Region: DUF3422; cl02073 1173020007024 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1173020007025 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1173020007026 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1173020007027 trimer interface [polypeptide binding]; other site 1173020007028 active site 1173020007029 UDP-GlcNAc binding site [chemical binding]; other site 1173020007030 lipid binding site [chemical binding]; lipid-binding site 1173020007031 Conserved TM helix; Region: TM_helix; pfam05552 1173020007032 Conserved TM helix; Region: TM_helix; pfam05552 1173020007033 Conserved TM helix; Region: TM_helix; pfam05552 1173020007034 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1173020007035 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1173020007036 NAD(P) binding site [chemical binding]; other site 1173020007037 catalytic residues [active] 1173020007038 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173020007039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173020007040 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1173020007041 ATP synthase CF0 A subunit; Region: atpI; CHL00046 1173020007042 ATP synthase CF0 C subunit; Region: atpH; CHL00061 1173020007043 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 1173020007044 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 1173020007045 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1173020007046 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 1173020007047 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1173020007048 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 1173020007049 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1173020007050 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1173020007051 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1173020007052 beta subunit interaction interface [polypeptide binding]; other site 1173020007053 Walker A motif; other site 1173020007054 ATP binding site [chemical binding]; other site 1173020007055 Walker B motif; other site 1173020007056 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1173020007057 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1173020007058 core domain interface [polypeptide binding]; other site 1173020007059 delta subunit interface [polypeptide binding]; other site 1173020007060 epsilon subunit interface [polypeptide binding]; other site 1173020007061 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1173020007062 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1173020007063 hydrolase, alpha/beta fold family protein; Region: PLN02824 1173020007064 catalytic site [active] 1173020007065 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1173020007066 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173020007067 glutathione synthetase; Provisional; Region: PRK05246 1173020007068 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1173020007069 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1173020007070 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1173020007071 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1173020007072 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1173020007073 Catalytic site [active] 1173020007074 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1173020007075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 1173020007076 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 1173020007077 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1173020007078 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1173020007079 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 1173020007080 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1173020007081 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 1173020007082 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1173020007083 EcsC protein family; Region: EcsC; pfam12787 1173020007084 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1173020007085 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1173020007086 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1173020007087 catalytic site [active] 1173020007088 active site 1173020007089 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1173020007090 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 1173020007091 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1173020007092 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1173020007093 active site 1173020007094 catalytic site [active] 1173020007095 Trehalase; Region: Trehalase; cl17346 1173020007096 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1173020007097 Sodium Bile acid symporter family; Region: SBF; cl17470 1173020007098 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173020007099 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173020007100 recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341 1173020007101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020007102 Walker A motif; other site 1173020007103 ATP binding site [chemical binding]; other site 1173020007104 Walker B motif; other site 1173020007105 arginine finger; other site 1173020007106 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1173020007107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173020007108 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1173020007109 MoxR-like ATPases [General function prediction only]; Region: COG0714 1173020007110 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020007111 Walker A motif; other site 1173020007112 ATP binding site [chemical binding]; other site 1173020007113 Walker B motif; other site 1173020007114 arginine finger; other site 1173020007115 Protein of unknown function DUF58; Region: DUF58; pfam01882 1173020007116 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1173020007117 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1173020007118 DNA photolyase; Region: DNA_photolyase; pfam00875 1173020007119 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 1173020007120 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173020007121 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173020007122 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020007123 Walker A/P-loop; other site 1173020007124 ATP binding site [chemical binding]; other site 1173020007125 Q-loop/lid; other site 1173020007126 ABC transporter signature motif; other site 1173020007127 Walker B; other site 1173020007128 D-loop; other site 1173020007129 H-loop/switch region; other site 1173020007130 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 1173020007131 PemK-like protein; Region: PemK; pfam02452 1173020007132 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1173020007133 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 1173020007134 SIR2-like domain; Region: SIR2_2; pfam13289 1173020007135 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1173020007136 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1173020007137 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; cl17321 1173020007138 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1173020007139 dinuclear metal binding motif [ion binding]; other site 1173020007140 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1173020007141 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1173020007142 active site residue [active] 1173020007143 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1173020007144 active site residue [active] 1173020007145 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020007146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020007147 active site 1173020007148 phosphorylation site [posttranslational modification] 1173020007149 intermolecular recognition site; other site 1173020007150 dimerization interface [polypeptide binding]; other site 1173020007151 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020007152 DNA binding site [nucleotide binding] 1173020007153 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1173020007154 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020007155 active site 1173020007156 ATP binding site [chemical binding]; other site 1173020007157 substrate binding site [chemical binding]; other site 1173020007158 activation loop (A-loop); other site 1173020007159 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1173020007160 dimer interface [polypeptide binding]; other site 1173020007161 [2Fe-2S] cluster binding site [ion binding]; other site 1173020007162 YGGT family; Region: YGGT; pfam02325 1173020007163 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1173020007164 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1173020007165 Walker A motif; other site 1173020007166 ATP binding site [chemical binding]; other site 1173020007167 Walker B motif; other site 1173020007168 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173020007169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020007170 active site 1173020007171 phosphorylation site [posttranslational modification] 1173020007172 intermolecular recognition site; other site 1173020007173 dimerization interface [polypeptide binding]; other site 1173020007174 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173020007175 DNA binding residues [nucleotide binding] 1173020007176 dimerization interface [polypeptide binding]; other site 1173020007177 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1173020007178 Histidine kinase; Region: HisKA_3; pfam07730 1173020007179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020007180 ATP binding site [chemical binding]; other site 1173020007181 Mg2+ binding site [ion binding]; other site 1173020007182 G-X-G motif; other site 1173020007183 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1173020007184 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1173020007185 LabA_like proteins; Region: LabA; cd10911 1173020007186 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1173020007187 putative metal binding site [ion binding]; other site 1173020007188 2-isopropylmalate synthase; Validated; Region: PRK00915 1173020007189 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1173020007190 active site 1173020007191 catalytic residues [active] 1173020007192 metal binding site [ion binding]; metal-binding site 1173020007193 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1173020007194 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 1173020007195 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173020007196 FeS/SAM binding site; other site 1173020007197 ribulose bisphosphate carboxylase/oxygenase activase -RuBisCO activase (RCA); Provisional; Region: PLN00020 1173020007198 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1173020007199 putative nucleotide binding site [chemical binding]; other site 1173020007200 uridine monophosphate binding site [chemical binding]; other site 1173020007201 homohexameric interface [polypeptide binding]; other site 1173020007202 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1173020007203 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1173020007204 hinge region; other site 1173020007205 GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450 1173020007206 GIY-YIG motif/motif A; other site 1173020007207 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173020007208 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173020007209 catalytic loop [active] 1173020007210 iron binding site [ion binding]; other site 1173020007211 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173020007212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020007213 binding surface 1173020007214 TPR repeat; Region: TPR_11; pfam13414 1173020007215 TPR motif; other site 1173020007216 TPR repeat; Region: TPR_11; pfam13414 1173020007217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020007218 binding surface 1173020007219 TPR motif; other site 1173020007220 TPR repeat; Region: TPR_11; pfam13414 1173020007221 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020007222 binding surface 1173020007223 TPR motif; other site 1173020007224 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1173020007225 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020007226 TPR repeat; Region: TPR_11; pfam13414 1173020007227 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020007228 binding surface 1173020007229 TPR motif; other site 1173020007230 TPR repeat; Region: TPR_11; pfam13414 1173020007231 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 1173020007232 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1173020007233 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1173020007234 RNA binding surface [nucleotide binding]; other site 1173020007235 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1173020007236 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1173020007237 FMN binding site [chemical binding]; other site 1173020007238 active site 1173020007239 catalytic residues [active] 1173020007240 substrate binding site [chemical binding]; other site 1173020007241 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1173020007242 Transposase domain (DUF772); Region: DUF772; pfam05598 1173020007243 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020007244 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1173020007245 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1173020007246 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173020007247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020007248 TPR motif; other site 1173020007249 binding surface 1173020007250 TPR repeat; Region: TPR_11; pfam13414 1173020007251 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020007252 binding surface 1173020007253 TPR motif; other site 1173020007254 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173020007255 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020007256 binding surface 1173020007257 TPR motif; other site 1173020007258 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1173020007259 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1173020007260 cofactor binding site; other site 1173020007261 DNA binding site [nucleotide binding] 1173020007262 substrate interaction site [chemical binding]; other site 1173020007263 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1173020007264 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1173020007265 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1173020007266 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173020007267 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173020007268 P-loop; other site 1173020007269 Magnesium ion binding site [ion binding]; other site 1173020007270 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173020007271 Magnesium ion binding site [ion binding]; other site 1173020007272 PetN; Region: PetN; pfam03742 1173020007273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020007274 MoxR-like ATPases [General function prediction only]; Region: COG0714 1173020007275 Walker A motif; other site 1173020007276 ATP binding site [chemical binding]; other site 1173020007277 Walker B motif; other site 1173020007278 arginine finger; other site 1173020007279 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1173020007280 MoaE homodimer interface [polypeptide binding]; other site 1173020007281 MoaD interaction [polypeptide binding]; other site 1173020007282 active site residues [active] 1173020007283 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1173020007284 GTP1/OBG; Region: GTP1_OBG; pfam01018 1173020007285 Obg GTPase; Region: Obg; cd01898 1173020007286 G1 box; other site 1173020007287 GTP/Mg2+ binding site [chemical binding]; other site 1173020007288 Switch I region; other site 1173020007289 G2 box; other site 1173020007290 G3 box; other site 1173020007291 Switch II region; other site 1173020007292 G4 box; other site 1173020007293 G5 box; other site 1173020007294 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1173020007295 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1173020007296 putative di-iron ligands [ion binding]; other site 1173020007297 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1173020007298 Fasciclin domain; Region: Fasciclin; pfam02469 1173020007299 hypothetical protein; Provisional; Region: PRK09256 1173020007300 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1173020007301 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1173020007302 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1173020007303 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1173020007304 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1173020007305 Predicted methyltransferases [General function prediction only]; Region: COG0313 1173020007306 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1173020007307 putative SAM binding site [chemical binding]; other site 1173020007308 putative homodimer interface [polypeptide binding]; other site 1173020007309 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1173020007310 aspartate aminotransferase; Provisional; Region: PRK05942 1173020007311 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173020007312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020007313 homodimer interface [polypeptide binding]; other site 1173020007314 catalytic residue [active] 1173020007315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719 1173020007316 CAAX protease self-immunity; Region: Abi; pfam02517 1173020007317 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1173020007318 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1173020007319 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 1173020007320 Iron-sulfur protein interface; other site 1173020007321 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020007322 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1173020007323 Walker A/P-loop; other site 1173020007324 ATP binding site [chemical binding]; other site 1173020007325 Q-loop/lid; other site 1173020007326 ABC transporter signature motif; other site 1173020007327 Walker B; other site 1173020007328 D-loop; other site 1173020007329 H-loop/switch region; other site 1173020007330 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1173020007331 phosphoribulokinase; Provisional; Region: PRK07429 1173020007332 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 1173020007333 active site 1173020007334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1173020007335 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1173020007336 Family of unknown function (DUF490); Region: DUF490; pfam04357 1173020007337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020007338 S-adenosylmethionine binding site [chemical binding]; other site 1173020007339 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1173020007340 nucleotide binding site/active site [active] 1173020007341 HIT family signature motif; other site 1173020007342 catalytic residue [active] 1173020007343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020007344 S-adenosylmethionine binding site [chemical binding]; other site 1173020007345 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 1173020007346 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173020007347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020007348 homodimer interface [polypeptide binding]; other site 1173020007349 catalytic residue [active] 1173020007350 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173020007351 catalytic residues [active] 1173020007352 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1173020007353 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020007354 motif II; other site 1173020007355 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 1173020007356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020007357 S-adenosylmethionine binding site [chemical binding]; other site 1173020007358 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 1173020007359 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 1173020007360 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1173020007361 Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331 1173020007362 ligand binding site [chemical binding]; other site 1173020007363 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1173020007364 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1173020007365 TM-ABC transporter signature motif; other site 1173020007366 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1173020007367 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1173020007368 TM-ABC transporter signature motif; other site 1173020007369 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1173020007370 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1173020007371 Walker A/P-loop; other site 1173020007372 ATP binding site [chemical binding]; other site 1173020007373 Q-loop/lid; other site 1173020007374 ABC transporter signature motif; other site 1173020007375 Walker B; other site 1173020007376 D-loop; other site 1173020007377 H-loop/switch region; other site 1173020007378 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1173020007379 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1173020007380 Walker A/P-loop; other site 1173020007381 ATP binding site [chemical binding]; other site 1173020007382 Q-loop/lid; other site 1173020007383 ABC transporter signature motif; other site 1173020007384 Walker B; other site 1173020007385 D-loop; other site 1173020007386 H-loop/switch region; other site 1173020007387 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1173020007388 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1173020007389 MOSC domain; Region: MOSC; pfam03473 1173020007390 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1173020007391 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1173020007392 NAD binding site [chemical binding]; other site 1173020007393 substrate binding site [chemical binding]; other site 1173020007394 homodimer interface [polypeptide binding]; other site 1173020007395 active site 1173020007396 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1173020007397 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1173020007398 substrate binding site; other site 1173020007399 tetramer interface; other site 1173020007400 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1173020007401 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1173020007402 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1173020007403 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173020007404 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1173020007405 Probable Catalytic site; other site 1173020007406 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173020007407 O-Antigen ligase; Region: Wzy_C; pfam04932 1173020007408 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173020007409 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020007410 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1173020007411 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020007412 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173020007413 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173020007414 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020007415 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1173020007416 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1173020007417 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1173020007418 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1173020007419 FOG: CBS domain [General function prediction only]; Region: COG0517 1173020007420 FOG: CBS domain [General function prediction only]; Region: COG0517 1173020007421 FOG: CBS domain [General function prediction only]; Region: COG0517 1173020007422 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 1173020007423 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020007424 PAS domain; Region: PAS_9; pfam13426 1173020007425 putative active site [active] 1173020007426 heme pocket [chemical binding]; other site 1173020007427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020007428 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173020007429 putative active site [active] 1173020007430 heme pocket [chemical binding]; other site 1173020007431 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020007432 putative active site [active] 1173020007433 heme pocket [chemical binding]; other site 1173020007434 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1173020007435 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020007436 putative active site [active] 1173020007437 heme pocket [chemical binding]; other site 1173020007438 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020007439 dimer interface [polypeptide binding]; other site 1173020007440 phosphorylation site [posttranslational modification] 1173020007441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020007442 ATP binding site [chemical binding]; other site 1173020007443 Mg2+ binding site [ion binding]; other site 1173020007444 G-X-G motif; other site 1173020007445 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020007446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020007447 active site 1173020007448 phosphorylation site [posttranslational modification] 1173020007449 intermolecular recognition site; other site 1173020007450 dimerization interface [polypeptide binding]; other site 1173020007451 acetylornithine aminotransferase; Provisional; Region: PRK02627 1173020007452 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1173020007453 inhibitor-cofactor binding pocket; inhibition site 1173020007454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020007455 catalytic residue [active] 1173020007456 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1173020007457 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1173020007458 metal-binding site [ion binding] 1173020007459 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173020007460 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1173020007461 agmatinase; Region: agmatinase; TIGR01230 1173020007462 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1173020007463 putative active site [active] 1173020007464 Mn binding site [ion binding]; other site 1173020007465 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879 1173020007466 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1173020007467 dimer interface [polypeptide binding]; other site 1173020007468 substrate binding site [chemical binding]; other site 1173020007469 metal binding sites [ion binding]; metal-binding site 1173020007470 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1173020007471 tetramerization interface [polypeptide binding]; other site 1173020007472 active site 1173020007473 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1173020007474 dimer interface [polypeptide binding]; other site 1173020007475 [2Fe-2S] cluster binding site [ion binding]; other site 1173020007476 Ferritin-like domain; Region: Ferritin; pfam00210 1173020007477 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1173020007478 dinuclear metal binding motif [ion binding]; other site 1173020007479 Transposase domain (DUF772); Region: DUF772; pfam05598 1173020007480 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020007481 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1173020007482 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 1173020007483 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1173020007484 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1173020007485 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1173020007486 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1173020007487 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1173020007488 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020007489 motif II; other site 1173020007490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020007491 S-adenosylmethionine binding site [chemical binding]; other site 1173020007492 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 1173020007493 GTP-binding protein LepA; Provisional; Region: PRK05433 1173020007494 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1173020007495 G1 box; other site 1173020007496 putative GEF interaction site [polypeptide binding]; other site 1173020007497 GTP/Mg2+ binding site [chemical binding]; other site 1173020007498 Switch I region; other site 1173020007499 G2 box; other site 1173020007500 G3 box; other site 1173020007501 Switch II region; other site 1173020007502 G4 box; other site 1173020007503 G5 box; other site 1173020007504 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1173020007505 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1173020007506 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1173020007507 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1173020007508 G1 box; other site 1173020007509 GTP/Mg2+ binding site [chemical binding]; other site 1173020007510 G2 box; other site 1173020007511 Switch I region; other site 1173020007512 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1173020007513 G3 box; other site 1173020007514 Switch II region; other site 1173020007515 G4 box; other site 1173020007516 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1173020007517 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173020007518 active site 1173020007519 biotin synthase; Validated; Region: PRK06256 1173020007520 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173020007521 FeS/SAM binding site; other site 1173020007522 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1173020007523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020007524 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020007525 active site 1173020007526 phosphorylation site [posttranslational modification] 1173020007527 intermolecular recognition site; other site 1173020007528 dimerization interface [polypeptide binding]; other site 1173020007529 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173020007530 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173020007531 metal binding site [ion binding]; metal-binding site 1173020007532 active site 1173020007533 I-site; other site 1173020007534 DNA polymerase III subunit delta'; Validated; Region: PRK07399 1173020007535 AAA ATPase domain; Region: AAA_16; pfam13191 1173020007536 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1173020007537 TPR repeat; Region: TPR_11; pfam13414 1173020007538 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020007539 binding surface 1173020007540 TPR repeat; Region: TPR_11; pfam13414 1173020007541 TPR motif; other site 1173020007542 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020007543 binding surface 1173020007544 TPR motif; other site 1173020007545 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173020007546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020007547 binding surface 1173020007548 TPR motif; other site 1173020007549 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020007550 binding surface 1173020007551 TPR motif; other site 1173020007552 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1173020007553 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1173020007554 amidohydrolase; Region: amidohydrolases; TIGR01891 1173020007555 metal binding site [ion binding]; metal-binding site 1173020007556 dimer interface [polypeptide binding]; other site 1173020007557 Bacterial Ig-like domain; Region: Big_5; pfam13205 1173020007558 TIGR03943 family protein; Region: TIGR03943 1173020007559 Predicted permeases [General function prediction only]; Region: COG0701 1173020007560 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1173020007561 RimM N-terminal domain; Region: RimM; pfam01782 1173020007562 PRC-barrel domain; Region: PRC; pfam05239 1173020007563 DDE superfamily endonuclease; Region: DDE_5; cl17874 1173020007564 yiaA/B two helix domain; Region: YiaAB; cl01759 1173020007565 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1173020007566 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173020007567 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 1173020007568 putative dimerization interface [polypeptide binding]; other site 1173020007569 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1173020007570 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1173020007571 hypothetical protein; Provisional; Region: PRK06850 1173020007572 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1173020007573 Active Sites [active] 1173020007574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173020007575 Protein of unknown function DUF262; Region: DUF262; pfam03235 1173020007576 DGQHR domain; Region: DGQHR; TIGR03187 1173020007577 DNA-sulfur modification-associated; Region: DndB; cl17621 1173020007578 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1173020007579 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1173020007580 MEKHLA domain; Region: MEKHLA; pfam08670 1173020007581 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1173020007582 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1173020007583 active site 1173020007584 intersubunit interface [polypeptide binding]; other site 1173020007585 catalytic residue [active] 1173020007586 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1173020007587 oligomerization interface [polypeptide binding]; other site 1173020007588 active site 1173020007589 metal binding site [ion binding]; metal-binding site 1173020007590 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1173020007591 UbiA prenyltransferase family; Region: UbiA; pfam01040 1173020007592 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1173020007593 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1173020007594 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1173020007595 dimerization interface [polypeptide binding]; other site 1173020007596 active site 1173020007597 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1173020007598 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1173020007599 folate binding site [chemical binding]; other site 1173020007600 NADP+ binding site [chemical binding]; other site 1173020007601 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1173020007602 catalytic motif [active] 1173020007603 Zn binding site [ion binding]; other site 1173020007604 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173020007605 CHAT domain; Region: CHAT; cl17868 1173020007606 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173020007607 phosphopeptide binding site; other site 1173020007608 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1173020007609 NTPase; Region: NTPase_1; cl17478 1173020007610 NACHT domain; Region: NACHT; pfam05729 1173020007611 RloB-like protein; Region: RloB; pfam13707 1173020007612 AAA domain; Region: AAA_21; pfam13304 1173020007613 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020007614 ABC transporter signature motif; other site 1173020007615 Walker B; other site 1173020007616 D-loop; other site 1173020007617 H-loop/switch region; other site 1173020007618 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1173020007619 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1173020007620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020007621 S-adenosylmethionine binding site [chemical binding]; other site 1173020007622 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173020007623 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173020007624 DDE superfamily endonuclease; Region: DDE_5; cl17874 1173020007625 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1173020007626 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1173020007627 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1173020007628 NAD(P) binding site [chemical binding]; other site 1173020007629 homodimer interface [polypeptide binding]; other site 1173020007630 substrate binding site [chemical binding]; other site 1173020007631 active site 1173020007632 S-layer homology domain; Region: SLH; pfam00395 1173020007633 S-layer homology domain; Region: SLH; pfam00395 1173020007634 S-layer homology domain; Region: SLH; pfam00395 1173020007635 S-layer homology domain; Region: SLH; pfam00395 1173020007636 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1173020007637 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020007638 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1173020007639 endonuclease III; Region: ENDO3c; smart00478 1173020007640 minor groove reading motif; other site 1173020007641 helix-hairpin-helix signature motif; other site 1173020007642 substrate binding pocket [chemical binding]; other site 1173020007643 active site 1173020007644 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1173020007645 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1173020007646 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173020007647 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173020007648 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173020007649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020007650 S-adenosylmethionine binding site [chemical binding]; other site 1173020007651 hypothetical protein; Provisional; Region: PRK10621 1173020007652 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1173020007653 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173020007654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020007655 S-adenosylmethionine binding site [chemical binding]; other site 1173020007656 Immunity protein Imm1; Region: Imm1; pfam14430 1173020007657 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1173020007658 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1173020007659 substrate binding site [chemical binding]; other site 1173020007660 ligand binding site [chemical binding]; other site 1173020007661 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173020007662 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020007663 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020007664 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020007665 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020007666 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020007667 putative active site [active] 1173020007668 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1173020007669 homotrimer interaction site [polypeptide binding]; other site 1173020007670 putative active site [active] 1173020007671 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1173020007672 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1173020007673 substrate binding site [chemical binding]; other site 1173020007674 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1173020007675 Cupin domain; Region: Cupin_2; cl17218 1173020007676 Predicted permeases [General function prediction only]; Region: COG0679 1173020007677 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173020007678 HSP70 interaction site [polypeptide binding]; other site 1173020007679 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 1173020007680 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 1173020007681 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1173020007682 tetramer interface [polypeptide binding]; other site 1173020007683 TPP-binding site [chemical binding]; other site 1173020007684 heterodimer interface [polypeptide binding]; other site 1173020007685 phosphorylation loop region [posttranslational modification] 1173020007686 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173020007687 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020007688 active site 1173020007689 ATP binding site [chemical binding]; other site 1173020007690 substrate binding site [chemical binding]; other site 1173020007691 activation loop (A-loop); other site 1173020007692 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1173020007693 AAA domain; Region: AAA_26; pfam13500 1173020007694 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1173020007695 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1173020007696 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 1173020007697 Cl binding site [ion binding]; other site 1173020007698 oligomer interface [polypeptide binding]; other site 1173020007699 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1173020007700 putative homodimer interface [polypeptide binding]; other site 1173020007701 putative active site pocket [active] 1173020007702 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1173020007703 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1173020007704 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1173020007705 catalytic triad [active] 1173020007706 thymidylate kinase; Validated; Region: tmk; PRK00698 1173020007707 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1173020007708 TMP-binding site; other site 1173020007709 ATP-binding site [chemical binding]; other site 1173020007710 S-layer homology domain; Region: SLH; pfam00395 1173020007711 S-layer homology domain; Region: SLH; pfam00395 1173020007712 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173020007713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020007714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020007715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 1173020007716 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173020007717 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020007718 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020007719 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020007720 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020007721 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020007722 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020007723 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020007724 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020007725 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 1173020007726 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173020007727 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173020007728 phosphopeptide binding site; other site 1173020007729 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173020007730 Ligand Binding Site [chemical binding]; other site 1173020007731 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173020007732 Ligand Binding Site [chemical binding]; other site 1173020007733 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1173020007734 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020007735 motif II; other site 1173020007736 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020007737 CTP synthetase; Validated; Region: pyrG; PRK05380 1173020007738 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1173020007739 Catalytic site [active] 1173020007740 active site 1173020007741 UTP binding site [chemical binding]; other site 1173020007742 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1173020007743 active site 1173020007744 putative oxyanion hole; other site 1173020007745 catalytic triad [active] 1173020007746 aspartate kinase; Provisional; Region: PRK07431 1173020007747 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1173020007748 putative nucleotide binding site [chemical binding]; other site 1173020007749 putative catalytic residues [active] 1173020007750 putative Mg ion binding site [ion binding]; other site 1173020007751 putative aspartate binding site [chemical binding]; other site 1173020007752 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1173020007753 putative allosteric regulatory site; other site 1173020007754 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1173020007755 putative allosteric regulatory residue; other site 1173020007756 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1173020007757 putative allosteric regulatory site; other site 1173020007758 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1173020007759 putative allosteric regulatory residue; other site 1173020007760 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1173020007761 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020007762 Coenzyme A binding pocket [chemical binding]; other site 1173020007763 Pirin-related protein [General function prediction only]; Region: COG1741 1173020007764 Pirin; Region: Pirin; pfam02678 1173020007765 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1173020007766 SnoaL-like domain; Region: SnoaL_2; pfam12680 1173020007767 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 1173020007768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020007769 dimer interface [polypeptide binding]; other site 1173020007770 ABC-ATPase subunit interface; other site 1173020007771 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1173020007772 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020007773 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1173020007774 Walker A/P-loop; other site 1173020007775 ATP binding site [chemical binding]; other site 1173020007776 Q-loop/lid; other site 1173020007777 ABC transporter signature motif; other site 1173020007778 Walker B; other site 1173020007779 D-loop; other site 1173020007780 H-loop/switch region; other site 1173020007781 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173020007782 HSP70 interaction site [polypeptide binding]; other site 1173020007783 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020007784 putative active site [active] 1173020007785 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1173020007786 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173020007787 ATP binding site [chemical binding]; other site 1173020007788 putative Mg++ binding site [ion binding]; other site 1173020007789 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173020007790 nucleotide binding region [chemical binding]; other site 1173020007791 ATP-binding site [chemical binding]; other site 1173020007792 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1173020007793 NAD-dependent deacetylase; Provisional; Region: PRK00481 1173020007794 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1173020007795 NAD+ binding site [chemical binding]; other site 1173020007796 substrate binding site [chemical binding]; other site 1173020007797 Zn binding site [ion binding]; other site 1173020007798 hypothetical protein; Reviewed; Region: PRK12497 1173020007799 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 1173020007800 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1173020007801 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1173020007802 dimer interface [polypeptide binding]; other site 1173020007803 putative anticodon binding site; other site 1173020007804 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1173020007805 motif 1; other site 1173020007806 active site 1173020007807 motif 2; other site 1173020007808 motif 3; other site 1173020007809 polyphosphate kinase; Provisional; Region: PRK05443 1173020007810 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1173020007811 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1173020007812 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1173020007813 putative domain interface [polypeptide binding]; other site 1173020007814 putative active site [active] 1173020007815 catalytic site [active] 1173020007816 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1173020007817 putative domain interface [polypeptide binding]; other site 1173020007818 putative active site [active] 1173020007819 catalytic site [active] 1173020007820 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1173020007821 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1173020007822 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1173020007823 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020007824 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1173020007825 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 1173020007826 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 1173020007827 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1173020007828 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1173020007829 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1173020007830 active site 1173020007831 dimer interface [polypeptide binding]; other site 1173020007832 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1173020007833 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1173020007834 active site 1173020007835 FMN binding site [chemical binding]; other site 1173020007836 substrate binding site [chemical binding]; other site 1173020007837 3Fe-4S cluster binding site [ion binding]; other site 1173020007838 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1173020007839 domain interface; other site 1173020007840 NB-ARC domain; Region: NB-ARC; pfam00931 1173020007841 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1173020007842 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020007843 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 1173020007844 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020007845 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl11892 1173020007846 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl09782 1173020007847 AAA ATPase domain; Region: AAA_16; pfam13191 1173020007848 AAA domain; Region: AAA_22; pfam13401 1173020007849 Integrase core domain; Region: rve; pfam00665 1173020007850 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 1173020007851 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 1173020007852 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1173020007853 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1173020007854 glutaminase active site [active] 1173020007855 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1173020007856 dimer interface [polypeptide binding]; other site 1173020007857 active site 1173020007858 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1173020007859 dimer interface [polypeptide binding]; other site 1173020007860 active site 1173020007861 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1173020007862 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020007863 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020007864 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020007865 photosystem I subunit VII; Region: psaC; CHL00065 1173020007866 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1173020007867 ribosomal protein L19; Region: rpl19; CHL00084 1173020007868 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1173020007869 active site 1173020007870 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1173020007871 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1173020007872 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1173020007873 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 1173020007874 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 1173020007875 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1173020007876 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1173020007877 active site 1173020007878 dimer interface [polypeptide binding]; other site 1173020007879 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1173020007880 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1173020007881 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1173020007882 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 1173020007883 catalytic site [active] 1173020007884 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173020007885 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173020007886 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020007887 TPR motif; other site 1173020007888 binding surface 1173020007889 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020007890 binding surface 1173020007891 TPR motif; other site 1173020007892 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020007893 binding surface 1173020007894 TPR motif; other site 1173020007895 TPR repeat; Region: TPR_11; pfam13414 1173020007896 TPR repeat; Region: TPR_11; pfam13414 1173020007897 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173020007898 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173020007899 active site 1173020007900 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1173020007901 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020007902 Walker A/P-loop; other site 1173020007903 ATP binding site [chemical binding]; other site 1173020007904 Q-loop/lid; other site 1173020007905 ABC transporter signature motif; other site 1173020007906 Walker B; other site 1173020007907 D-loop; other site 1173020007908 H-loop/switch region; other site 1173020007909 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1173020007910 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1173020007911 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1173020007912 Pterin 4 alpha carbinolamine dehydratase; Region: Pterin_4a; pfam01329 1173020007913 aromatic arch; other site 1173020007914 DCoH dimer interaction site [polypeptide binding]; other site 1173020007915 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1173020007916 DCoH tetramer interaction site [polypeptide binding]; other site 1173020007917 substrate binding site [chemical binding]; other site 1173020007918 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1173020007919 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1173020007920 NodB motif; other site 1173020007921 active site 1173020007922 catalytic site [active] 1173020007923 metal binding site [ion binding]; metal-binding site 1173020007924 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1173020007925 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1173020007926 RNA binding site [nucleotide binding]; other site 1173020007927 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1173020007928 RNA binding site [nucleotide binding]; other site 1173020007929 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1173020007930 RNA binding site [nucleotide binding]; other site 1173020007931 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1173020007932 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1173020007933 HflX GTPase family; Region: HflX; cd01878 1173020007934 G1 box; other site 1173020007935 GTP/Mg2+ binding site [chemical binding]; other site 1173020007936 Switch I region; other site 1173020007937 G2 box; other site 1173020007938 G3 box; other site 1173020007939 Switch II region; other site 1173020007940 G4 box; other site 1173020007941 G5 box; other site 1173020007942 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1173020007943 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020007944 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020007945 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020007946 YcxB-like protein; Region: YcxB; pfam14317 1173020007947 DNA polymerase I; Provisional; Region: PRK05755 1173020007948 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1173020007949 active site 1173020007950 metal binding site 1 [ion binding]; metal-binding site 1173020007951 putative 5' ssDNA interaction site; other site 1173020007952 metal binding site 3; metal-binding site 1173020007953 metal binding site 2 [ion binding]; metal-binding site 1173020007954 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1173020007955 putative DNA binding site [nucleotide binding]; other site 1173020007956 putative metal binding site [ion binding]; other site 1173020007957 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1173020007958 active site 1173020007959 catalytic site [active] 1173020007960 substrate binding site [chemical binding]; other site 1173020007961 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1173020007962 active site 1173020007963 DNA binding site [nucleotide binding] 1173020007964 catalytic site [active] 1173020007965 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1173020007966 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173020007967 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1173020007968 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1173020007969 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1173020007970 active site 1173020007971 HIGH motif; other site 1173020007972 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1173020007973 KMSKS motif; other site 1173020007974 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1173020007975 glycine dehydrogenase; Provisional; Region: PRK05367 1173020007976 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1173020007977 tetramer interface [polypeptide binding]; other site 1173020007978 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020007979 catalytic residue [active] 1173020007980 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1173020007981 tetramer interface [polypeptide binding]; other site 1173020007982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020007983 catalytic residue [active] 1173020007984 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1173020007985 lipoyl attachment site [posttranslational modification]; other site 1173020007986 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173020007987 TPR repeat; Region: TPR_11; pfam13414 1173020007988 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020007989 binding surface 1173020007990 TPR motif; other site 1173020007991 TPR repeat; Region: TPR_11; pfam13414 1173020007992 TPR repeat; Region: TPR_11; pfam13414 1173020007993 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020007994 binding surface 1173020007995 TPR motif; other site 1173020007996 TPR repeat; Region: TPR_11; pfam13414 1173020007997 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020007998 binding surface 1173020007999 TPR motif; other site 1173020008000 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1173020008001 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173020008002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020008003 binding surface 1173020008004 TPR motif; other site 1173020008005 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173020008006 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020008007 binding surface 1173020008008 TPR motif; other site 1173020008009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020008010 binding surface 1173020008011 TPR motif; other site 1173020008012 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1173020008013 Part of AAA domain; Region: AAA_19; pfam13245 1173020008014 Family description; Region: UvrD_C_2; pfam13538 1173020008015 Protein of unknown function (DUF938); Region: DUF938; pfam06080 1173020008016 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173020008017 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020008018 ferredoxin-sulfite reductase; Region: sir; TIGR02042 1173020008019 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1173020008020 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1173020008021 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1173020008022 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 1173020008023 putative active site [active] 1173020008024 Zn binding site [ion binding]; other site 1173020008025 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1173020008026 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020008027 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020008028 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020008029 photochlorophyllide reductase subunit B; Region: chlB; CHL00076 1173020008030 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 1173020008031 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 1173020008032 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1173020008033 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1173020008034 dimer interface [polypeptide binding]; other site 1173020008035 tetramer interface [polypeptide binding]; other site 1173020008036 PYR/PP interface [polypeptide binding]; other site 1173020008037 TPP binding site [chemical binding]; other site 1173020008038 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1173020008039 TPP-binding site; other site 1173020008040 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 1173020008041 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1173020008042 TPP-binding site [chemical binding]; other site 1173020008043 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1173020008044 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1173020008045 Fasciclin domain; Region: Fasciclin; pfam02469 1173020008046 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1173020008047 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1173020008048 active site 1173020008049 homodimer interface [polypeptide binding]; other site 1173020008050 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020008051 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173020008052 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020008053 active site 1173020008054 ATP binding site [chemical binding]; other site 1173020008055 substrate binding site [chemical binding]; other site 1173020008056 activation loop (A-loop); other site 1173020008057 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 1173020008058 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1173020008059 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1173020008060 alpha subunit interaction interface [polypeptide binding]; other site 1173020008061 Walker A motif; other site 1173020008062 ATP binding site [chemical binding]; other site 1173020008063 Walker B motif; other site 1173020008064 inhibitor binding site; inhibition site 1173020008065 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1173020008066 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 1173020008067 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1173020008068 gamma subunit interface [polypeptide binding]; other site 1173020008069 epsilon subunit interface [polypeptide binding]; other site 1173020008070 LBP interface [polypeptide binding]; other site 1173020008071 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12621 1173020008072 Predicted membrane protein [Function unknown]; Region: COG3431 1173020008073 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1173020008074 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1173020008075 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020008076 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020008077 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020008078 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020008079 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020008080 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 1173020008081 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1173020008082 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1173020008083 dimerization interface [polypeptide binding]; other site 1173020008084 active site 1173020008085 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1173020008086 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1173020008087 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020008088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020008089 active site 1173020008090 phosphorylation site [posttranslational modification] 1173020008091 intermolecular recognition site; other site 1173020008092 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020008093 dimerization interface [polypeptide binding]; other site 1173020008094 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1173020008095 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1173020008096 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1173020008097 active site 1173020008098 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1173020008099 substrate binding site [chemical binding]; other site 1173020008100 catalytic residues [active] 1173020008101 dimer interface [polypeptide binding]; other site 1173020008102 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1173020008103 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1173020008104 Walker A/P-loop; other site 1173020008105 ATP binding site [chemical binding]; other site 1173020008106 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1173020008107 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1173020008108 ABC transporter signature motif; other site 1173020008109 Walker B; other site 1173020008110 D-loop; other site 1173020008111 H-loop/switch region; other site 1173020008112 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1173020008113 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1173020008114 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173020008115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020008116 putative substrate translocation pore; other site 1173020008117 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173020008118 active site 1173020008119 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 1173020008120 TPR repeat; Region: TPR_11; pfam13414 1173020008121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020008122 binding surface 1173020008123 TPR motif; other site 1173020008124 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173020008125 TPR motif; other site 1173020008126 TPR repeat; Region: TPR_11; pfam13414 1173020008127 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020008128 TPR motif; other site 1173020008129 binding surface 1173020008130 TPR repeat; Region: TPR_11; pfam13414 1173020008131 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173020008132 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1173020008133 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173020008134 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173020008135 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1173020008136 protein binding site [polypeptide binding]; other site 1173020008137 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173020008138 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173020008139 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173020008140 DNA binding residues [nucleotide binding] 1173020008141 dimerization interface [polypeptide binding]; other site 1173020008142 Clp protease; Region: CLP_protease; pfam00574 1173020008143 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1173020008144 oligomer interface [polypeptide binding]; other site 1173020008145 active site residues [active] 1173020008146 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1173020008147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1173020008148 DinB superfamily; Region: DinB_2; pfam12867 1173020008149 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1173020008150 TPR repeat; Region: TPR_11; pfam13414 1173020008151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173020008152 TPR motif; other site 1173020008153 binding surface 1173020008154 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1173020008155 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1173020008156 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 1173020008157 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 1173020008158 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020008159 putative active site [active] 1173020008160 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1173020008161 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1173020008162 interface (dimer of trimers) [polypeptide binding]; other site 1173020008163 Substrate-binding/catalytic site; other site 1173020008164 Zn-binding sites [ion binding]; other site 1173020008165 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173020008166 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1173020008167 S-formylglutathione hydrolase; Region: PLN02442 1173020008168 EamA-like transporter family; Region: EamA; pfam00892 1173020008169 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1173020008170 EamA-like transporter family; Region: EamA; pfam00892 1173020008171 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1173020008172 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1173020008173 tandem repeat interface [polypeptide binding]; other site 1173020008174 oligomer interface [polypeptide binding]; other site 1173020008175 active site residues [active] 1173020008176 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1173020008177 homotrimer interaction site [polypeptide binding]; other site 1173020008178 active site 1173020008179 CheB methylesterase; Region: CheB_methylest; pfam01339 1173020008180 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1173020008181 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1173020008182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020008183 S-adenosylmethionine binding site [chemical binding]; other site 1173020008184 PAS domain; Region: PAS_10; pfam13596 1173020008185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020008186 putative active site [active] 1173020008187 heme pocket [chemical binding]; other site 1173020008188 PAS domain; Region: PAS_9; pfam13426 1173020008189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1173020008190 Histidine kinase; Region: HisKA_2; pfam07568 1173020008191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020008192 ATP binding site [chemical binding]; other site 1173020008193 Mg2+ binding site [ion binding]; other site 1173020008194 G-X-G motif; other site 1173020008195 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020008196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020008197 active site 1173020008198 phosphorylation site [posttranslational modification] 1173020008199 intermolecular recognition site; other site 1173020008200 dimerization interface [polypeptide binding]; other site 1173020008201 PAS fold; Region: PAS; pfam00989 1173020008202 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020008203 putative active site [active] 1173020008204 heme pocket [chemical binding]; other site 1173020008205 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020008206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020008207 active site 1173020008208 phosphorylation site [posttranslational modification] 1173020008209 intermolecular recognition site; other site 1173020008210 dimerization interface [polypeptide binding]; other site 1173020008211 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020008212 PAS domain; Region: PAS_9; pfam13426 1173020008213 putative active site [active] 1173020008214 heme pocket [chemical binding]; other site 1173020008215 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020008216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020008217 ATP binding site [chemical binding]; other site 1173020008218 Mg2+ binding site [ion binding]; other site 1173020008219 G-X-G motif; other site 1173020008220 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 1173020008221 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173020008222 FeS/SAM binding site; other site 1173020008223 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1173020008224 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1173020008225 generic binding surface II; other site 1173020008226 ssDNA binding site; other site 1173020008227 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173020008228 ATP binding site [chemical binding]; other site 1173020008229 putative Mg++ binding site [ion binding]; other site 1173020008230 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173020008231 nucleotide binding region [chemical binding]; other site 1173020008232 ATP-binding site [chemical binding]; other site 1173020008233 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1173020008234 GMP synthase; Reviewed; Region: guaA; PRK00074 1173020008235 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1173020008236 AMP/PPi binding site [chemical binding]; other site 1173020008237 candidate oxyanion hole; other site 1173020008238 catalytic triad [active] 1173020008239 potential glutamine specificity residues [chemical binding]; other site 1173020008240 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1173020008241 ATP Binding subdomain [chemical binding]; other site 1173020008242 Ligand Binding sites [chemical binding]; other site 1173020008243 Dimerization subdomain; other site 1173020008244 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1173020008245 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1173020008246 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173020008247 dimerization interface [polypeptide binding]; other site 1173020008248 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173020008249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020008250 dimer interface [polypeptide binding]; other site 1173020008251 phosphorylation site [posttranslational modification] 1173020008252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020008253 ATP binding site [chemical binding]; other site 1173020008254 Mg2+ binding site [ion binding]; other site 1173020008255 G-X-G motif; other site 1173020008256 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1173020008257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020008258 S-adenosylmethionine binding site [chemical binding]; other site 1173020008259 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1173020008260 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1173020008261 ligand binding site [chemical binding]; other site 1173020008262 NAD binding site [chemical binding]; other site 1173020008263 dimerization interface [polypeptide binding]; other site 1173020008264 catalytic site [active] 1173020008265 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1173020008266 putative L-serine binding site [chemical binding]; other site 1173020008267 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 1173020008268 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1173020008269 RNA binding surface [nucleotide binding]; other site 1173020008270 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 1173020008271 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1173020008272 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 1173020008273 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1173020008274 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1173020008275 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1173020008276 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1173020008277 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1173020008278 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1173020008279 active site 1173020008280 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1173020008281 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1173020008282 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1173020008283 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 1173020008284 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1173020008285 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1173020008286 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1173020008287 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1173020008288 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1173020008289 substrate binding pocket [chemical binding]; other site 1173020008290 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1173020008291 B12 binding site [chemical binding]; other site 1173020008292 cobalt ligand [ion binding]; other site 1173020008293 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1173020008294 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1173020008295 putative active site [active] 1173020008296 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 1173020008297 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1173020008298 active site 1173020008299 substrate binding site [chemical binding]; other site 1173020008300 metal binding site [ion binding]; metal-binding site 1173020008301 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020008302 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020008303 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1173020008304 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1173020008305 nucleotide binding site [chemical binding]; other site 1173020008306 NEF interaction site [polypeptide binding]; other site 1173020008307 SBD interface [polypeptide binding]; other site 1173020008308 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 1173020008309 DRTGG domain; Region: DRTGG; pfam07085 1173020008310 Circadian oscillating protein COP23; Region: COP23; pfam14218 1173020008311 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1173020008312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020008313 Walker A motif; other site 1173020008314 ATP binding site [chemical binding]; other site 1173020008315 Walker B motif; other site 1173020008316 arginine finger; other site 1173020008317 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1173020008318 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1173020008319 domain interfaces; other site 1173020008320 active site 1173020008321 TPR repeat; Region: TPR_11; pfam13414 1173020008322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020008323 binding surface 1173020008324 TPR motif; other site 1173020008325 TPR repeat; Region: TPR_11; pfam13414 1173020008326 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1173020008327 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1173020008328 Chromate transporter; Region: Chromate_transp; pfam02417 1173020008329 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1173020008330 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1173020008331 oligomer interface [polypeptide binding]; other site 1173020008332 active site residues [active] 1173020008333 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1173020008334 putative ADP-binding pocket [chemical binding]; other site 1173020008335 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020008336 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 1173020008337 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1173020008338 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1173020008339 putative DNA binding site [nucleotide binding]; other site 1173020008340 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 1173020008341 putative Zn2+ binding site [ion binding]; other site 1173020008342 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 1173020008343 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 1173020008344 Ligand Binding Site [chemical binding]; other site 1173020008345 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1173020008346 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1173020008347 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1173020008348 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1173020008349 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1173020008350 HD domain; Region: HD_4; pfam13328 1173020008351 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1173020008352 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173020008353 C-terminal domain interface [polypeptide binding]; other site 1173020008354 GSH binding site (G-site) [chemical binding]; other site 1173020008355 dimer interface [polypeptide binding]; other site 1173020008356 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1173020008357 N-terminal domain interface [polypeptide binding]; other site 1173020008358 dimer interface [polypeptide binding]; other site 1173020008359 substrate binding pocket (H-site) [chemical binding]; other site 1173020008360 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1173020008361 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1173020008362 B12 binding site [chemical binding]; other site 1173020008363 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 1173020008364 dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062 1173020008365 methionine aminopeptidase; Provisional; Region: PRK12318 1173020008366 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1173020008367 active site 1173020008368 SH3 domain-containing protein; Provisional; Region: PRK10884 1173020008369 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1173020008370 gamma-beta subunit interface [polypeptide binding]; other site 1173020008371 alpha-beta subunit interface [polypeptide binding]; other site 1173020008372 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1173020008373 ABC1 family; Region: ABC1; cl17513 1173020008374 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1173020008375 nucleoside/Zn binding site; other site 1173020008376 dimer interface [polypeptide binding]; other site 1173020008377 catalytic motif [active] 1173020008378 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 1173020008379 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173020008380 FeS/SAM binding site; other site 1173020008381 HemN C-terminal domain; Region: HemN_C; pfam06969 1173020008382 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1173020008383 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1173020008384 C-terminal domain interface [polypeptide binding]; other site 1173020008385 GSH binding site (G-site) [chemical binding]; other site 1173020008386 dimer interface [polypeptide binding]; other site 1173020008387 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1173020008388 N-terminal domain interface [polypeptide binding]; other site 1173020008389 dimer interface [polypeptide binding]; other site 1173020008390 substrate binding pocket (H-site) [chemical binding]; other site 1173020008391 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1173020008392 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173020008393 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1173020008394 putative acyl-acceptor binding pocket; other site 1173020008395 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1173020008396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1173020008397 ATP binding site [chemical binding]; other site 1173020008398 Mg2+ binding site [ion binding]; other site 1173020008399 G-X-G motif; other site 1173020008400 Integral membrane protein TerC family; Region: TerC; cl10468 1173020008401 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1173020008402 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1173020008403 dimer interface [polypeptide binding]; other site 1173020008404 ssDNA binding site [nucleotide binding]; other site 1173020008405 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1173020008406 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1173020008407 active site 1173020008408 SAM binding site [chemical binding]; other site 1173020008409 homodimer interface [polypeptide binding]; other site 1173020008410 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1173020008411 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1173020008412 active site 1173020008413 translation initiation factor IF-2; Region: IF-2; TIGR00487 1173020008414 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1173020008415 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1173020008416 G1 box; other site 1173020008417 putative GEF interaction site [polypeptide binding]; other site 1173020008418 GTP/Mg2+ binding site [chemical binding]; other site 1173020008419 Switch I region; other site 1173020008420 G2 box; other site 1173020008421 G3 box; other site 1173020008422 Switch II region; other site 1173020008423 G4 box; other site 1173020008424 G5 box; other site 1173020008425 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1173020008426 Translation-initiation factor 2; Region: IF-2; pfam11987 1173020008427 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1173020008428 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1173020008429 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1173020008430 active site 1173020008431 catalytic site [active] 1173020008432 substrate binding site [chemical binding]; other site 1173020008433 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1173020008434 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173020008435 active site 1173020008436 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173020008437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020008438 S-adenosylmethionine binding site [chemical binding]; other site 1173020008439 DNA methylase; Region: N6_N4_Mtase; cl17433 1173020008440 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173020008441 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173020008442 active site 1173020008443 catalytic tetrad [active] 1173020008444 alanine racemase; Reviewed; Region: alr; PRK00053 1173020008445 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1173020008446 active site 1173020008447 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1173020008448 dimer interface [polypeptide binding]; other site 1173020008449 substrate binding site [chemical binding]; other site 1173020008450 catalytic residues [active] 1173020008451 phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338 1173020008452 Phycobilisome protein; Region: Phycobilisome; cl08227 1173020008453 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173020008454 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1173020008455 Walker A/P-loop; other site 1173020008456 ATP binding site [chemical binding]; other site 1173020008457 Q-loop/lid; other site 1173020008458 ABC transporter signature motif; other site 1173020008459 Walker B; other site 1173020008460 D-loop; other site 1173020008461 H-loop/switch region; other site 1173020008462 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1173020008463 active site 1173020008464 8-oxo-dGMP binding site [chemical binding]; other site 1173020008465 nudix motif; other site 1173020008466 metal binding site [ion binding]; metal-binding site 1173020008467 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 1173020008468 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1173020008469 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173020008470 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173020008471 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173020008472 DNA binding residues [nucleotide binding] 1173020008473 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173020008474 catalytic core [active] 1173020008475 YacP-like NYN domain; Region: NYN_YacP; pfam05991 1173020008476 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1173020008477 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1173020008478 Walker A/P-loop; other site 1173020008479 ATP binding site [chemical binding]; other site 1173020008480 Q-loop/lid; other site 1173020008481 ABC transporter signature motif; other site 1173020008482 Walker B; other site 1173020008483 D-loop; other site 1173020008484 H-loop/switch region; other site 1173020008485 hypothetical protein; Provisional; Region: PRK13683 1173020008486 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 1173020008487 D1 interface; other site 1173020008488 chlorophyll binding site; other site 1173020008489 pheophytin binding site; other site 1173020008490 beta carotene binding site; other site 1173020008491 cytochrome b559 beta interface; other site 1173020008492 quinone binding site; other site 1173020008493 cytochrome b559 alpha interface; other site 1173020008494 protein J interface; other site 1173020008495 protein H interface; other site 1173020008496 protein X interface; other site 1173020008497 core light harvesting protein interface; other site 1173020008498 protein L interface; other site 1173020008499 CP43 interface; other site 1173020008500 protein T interface; other site 1173020008501 Fe binding site [ion binding]; other site 1173020008502 protein M interface; other site 1173020008503 Mn-stabilizing polypeptide interface; other site 1173020008504 bromide binding site; other site 1173020008505 cytochrome c-550 interface; other site 1173020008506 photosystem II 44 kDa protein; Region: psbC; CHL00035 1173020008507 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 1173020008508 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1173020008509 Protein of unknown function (DUF751); Region: DUF751; pfam05421 1173020008510 Peptidase M15; Region: Peptidase_M15_3; cl01194 1173020008511 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1173020008512 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1173020008513 catalytic residues [active] 1173020008514 catalytic nucleophile [active] 1173020008515 Presynaptic Site I dimer interface [polypeptide binding]; other site 1173020008516 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1173020008517 Synaptic Flat tetramer interface [polypeptide binding]; other site 1173020008518 Synaptic Site I dimer interface [polypeptide binding]; other site 1173020008519 DNA binding site [nucleotide binding] 1173020008520 Organiser of macrodomain of Terminus of chromosome; Region: MatP; cl11476 1173020008521 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173020008522 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173020008523 Probable transposase; Region: OrfB_IS605; pfam01385 1173020008524 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173020008525 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1173020008526 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1173020008527 DNA binding residues [nucleotide binding] 1173020008528 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1173020008529 catalytic residues [active] 1173020008530 catalytic nucleophile [active] 1173020008531 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1173020008532 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1173020008533 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1173020008534 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1173020008535 hypothetical protein; Reviewed; Region: PRK09588 1173020008536 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1173020008537 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173020008538 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 1173020008539 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020008540 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020008541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020008542 active site 1173020008543 phosphorylation site [posttranslational modification] 1173020008544 intermolecular recognition site; other site 1173020008545 dimerization interface [polypeptide binding]; other site 1173020008546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020008547 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020008548 active site 1173020008549 phosphorylation site [posttranslational modification] 1173020008550 intermolecular recognition site; other site 1173020008551 dimerization interface [polypeptide binding]; other site 1173020008552 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1173020008553 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173020008554 dimerization interface [polypeptide binding]; other site 1173020008555 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020008556 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020008557 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020008558 GAF domain; Region: GAF; pfam01590 1173020008559 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020008560 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020008561 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020008562 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020008563 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020008564 GAF domain; Region: GAF; pfam01590 1173020008565 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1173020008566 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173020008567 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173020008568 dimer interface [polypeptide binding]; other site 1173020008569 putative CheW interface [polypeptide binding]; other site 1173020008570 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173020008571 putative binding surface; other site 1173020008572 active site 1173020008573 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173020008574 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1173020008575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020008576 ATP binding site [chemical binding]; other site 1173020008577 Mg2+ binding site [ion binding]; other site 1173020008578 G-X-G motif; other site 1173020008579 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173020008580 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020008581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020008582 active site 1173020008583 phosphorylation site [posttranslational modification] 1173020008584 intermolecular recognition site; other site 1173020008585 dimerization interface [polypeptide binding]; other site 1173020008586 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 1173020008587 CoA binding domain; Region: CoA_binding; pfam02629 1173020008588 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1173020008589 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1173020008590 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1173020008591 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1173020008592 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1173020008593 substrate binding site; other site 1173020008594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173020008595 NAD(P) binding site [chemical binding]; other site 1173020008596 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173020008597 active site 1173020008598 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1173020008599 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173020008600 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1173020008601 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1173020008602 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1173020008603 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173020008604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020008605 S-adenosylmethionine binding site [chemical binding]; other site 1173020008606 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1173020008607 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020008608 Coenzyme A binding pocket [chemical binding]; other site 1173020008609 WbqC-like protein family; Region: WbqC; pfam08889 1173020008610 Cephalosporin hydroxylase; Region: CmcI; pfam04989 1173020008611 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1173020008612 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1173020008613 inhibitor-cofactor binding pocket; inhibition site 1173020008614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020008615 catalytic residue [active] 1173020008616 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173020008617 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173020008618 active site 1173020008619 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1173020008620 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020008621 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1173020008622 4Fe-4S binding domain; Region: Fer4; pfam00037 1173020008623 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1173020008624 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1173020008625 trimer interface [polypeptide binding]; other site 1173020008626 dimer interface [polypeptide binding]; other site 1173020008627 putative active site [active] 1173020008628 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1173020008629 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173020008630 catalytic residues [active] 1173020008631 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1173020008632 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 1173020008633 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 1173020008634 dimerization interface [polypeptide binding]; other site 1173020008635 FAD binding pocket [chemical binding]; other site 1173020008636 FAD binding motif [chemical binding]; other site 1173020008637 catalytic residues [active] 1173020008638 NAD binding pocket [chemical binding]; other site 1173020008639 phosphate binding motif [ion binding]; other site 1173020008640 beta-alpha-beta structure motif; other site 1173020008641 phosphoribulokinase; Provisional; Region: PRK07429 1173020008642 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 1173020008643 active site 1173020008644 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020008645 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 1173020008646 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1173020008647 dimer interface [polypeptide binding]; other site 1173020008648 catalytic triad [active] 1173020008649 Double zinc ribbon; Region: DZR; pfam12773 1173020008650 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1173020008651 Protein phosphatase 2C; Region: PP2C; pfam00481 1173020008652 active site 1173020008653 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 1173020008654 active site 1173020008655 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 1173020008656 DNA photolyase; Region: DNA_photolyase; pfam00875 1173020008657 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1173020008658 ABC1 family; Region: ABC1; cl17513 1173020008659 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1173020008660 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1173020008661 NADP binding site [chemical binding]; other site 1173020008662 active site 1173020008663 putative substrate binding site [chemical binding]; other site 1173020008664 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1173020008665 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 1173020008666 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1173020008667 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173020008668 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173020008669 catalytic residue [active] 1173020008670 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173020008671 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020008672 active site 1173020008673 ATP binding site [chemical binding]; other site 1173020008674 substrate binding site [chemical binding]; other site 1173020008675 activation loop (A-loop); other site 1173020008676 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1173020008677 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1173020008678 cytochrome c-550; Region: PS_II_C550; TIGR03045 1173020008679 Cytochrome c; Region: Cytochrom_C; cl11414 1173020008680 NurA domain; Region: NurA; pfam09376 1173020008681 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020008682 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173020008683 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020008684 active site 1173020008685 ATP binding site [chemical binding]; other site 1173020008686 substrate binding site [chemical binding]; other site 1173020008687 activation loop (A-loop); other site 1173020008688 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1173020008689 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1173020008690 KH domain; Region: KH_4; pfam13083 1173020008691 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1173020008692 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1173020008693 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1173020008694 NAD(P) binding site [chemical binding]; other site 1173020008695 catalytic residues [active] 1173020008696 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1173020008697 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1173020008698 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173020008699 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1173020008700 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1173020008701 multidrug efflux protein; Reviewed; Region: PRK01766 1173020008702 cation binding site [ion binding]; other site 1173020008703 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1173020008704 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1173020008705 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1173020008706 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1173020008707 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1173020008708 dimer interface [polypeptide binding]; other site 1173020008709 motif 1; other site 1173020008710 active site 1173020008711 motif 2; other site 1173020008712 motif 3; other site 1173020008713 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 1173020008714 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1173020008715 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1173020008716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020008717 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1173020008718 Coenzyme A binding pocket [chemical binding]; other site 1173020008719 Ycf39; Provisional; Region: ycf39; CHL00194 1173020008720 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1173020008721 NAD(P) binding site [chemical binding]; other site 1173020008722 putative active site [active] 1173020008723 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 1173020008724 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1173020008725 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020008726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020008727 active site 1173020008728 phosphorylation site [posttranslational modification] 1173020008729 intermolecular recognition site; other site 1173020008730 dimerization interface [polypeptide binding]; other site 1173020008731 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020008732 DNA binding site [nucleotide binding] 1173020008733 Cupin domain; Region: Cupin_2; cl17218 1173020008734 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1173020008735 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 1173020008736 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1173020008737 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020008738 active site 1173020008739 motif I; other site 1173020008740 motif II; other site 1173020008741 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1173020008742 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 1173020008743 Helix-turn-helix domain; Region: HTH_17; cl17695 1173020008744 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1173020008745 KWG Leptospira; Region: KWG; pfam07656 1173020008746 KWG Leptospira; Region: KWG; pfam07656 1173020008747 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1173020008748 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1173020008749 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1173020008750 Moco binding site; other site 1173020008751 metal coordination site [ion binding]; other site 1173020008752 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1173020008753 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1173020008754 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1173020008755 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 1173020008756 dimer interface [polypeptide binding]; other site 1173020008757 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1173020008758 Histidine kinase; Region: HisKA_3; pfam07730 1173020008759 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020008760 ATP binding site [chemical binding]; other site 1173020008761 Mg2+ binding site [ion binding]; other site 1173020008762 G-X-G motif; other site 1173020008763 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 1173020008764 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1173020008765 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1173020008766 putative active site [active] 1173020008767 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1173020008768 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1173020008769 catalytic motif [active] 1173020008770 Zn binding site [ion binding]; other site 1173020008771 RibD C-terminal domain; Region: RibD_C; cl17279 1173020008772 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1173020008773 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020008774 motif II; other site 1173020008775 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1173020008776 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1173020008777 NAD binding site [chemical binding]; other site 1173020008778 homodimer interface [polypeptide binding]; other site 1173020008779 active site 1173020008780 substrate binding site [chemical binding]; other site 1173020008781 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1173020008782 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1173020008783 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1173020008784 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1173020008785 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 1173020008786 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173020008787 NAD binding site [chemical binding]; other site 1173020008788 substrate binding site [chemical binding]; other site 1173020008789 active site 1173020008790 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 1173020008791 L-aspartate oxidase; Provisional; Region: PRK07395 1173020008792 L-aspartate oxidase; Provisional; Region: PRK06175 1173020008793 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1173020008794 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1173020008795 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1173020008796 Catalytic site [active] 1173020008797 patatin-related protein; Region: TIGR03607 1173020008798 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1173020008799 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1173020008800 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1173020008801 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1173020008802 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 1173020008803 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1173020008804 protein binding site [polypeptide binding]; other site 1173020008805 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1173020008806 Catalytic dyad [active] 1173020008807 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1173020008808 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020008809 Coenzyme A binding pocket [chemical binding]; other site 1173020008810 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 1173020008811 active site 1173020008812 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 1173020008813 active site 1173020008814 intersubunit interface [polypeptide binding]; other site 1173020008815 catalytic residue [active] 1173020008816 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1173020008817 Peptidase family M23; Region: Peptidase_M23; pfam01551 1173020008818 lipoyl synthase; Provisional; Region: PRK05481 1173020008819 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1173020008820 FeS/SAM binding site; other site 1173020008821 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 1173020008822 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1173020008823 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1173020008824 Dynamin family; Region: Dynamin_N; pfam00350 1173020008825 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 1173020008826 G1 box; other site 1173020008827 GTP/Mg2+ binding site [chemical binding]; other site 1173020008828 Switch I region; other site 1173020008829 G2 box; other site 1173020008830 Switch II region; other site 1173020008831 G3 box; other site 1173020008832 G4 box; other site 1173020008833 G5 box; other site 1173020008834 Domain of unknown function (DUF697); Region: DUF697; pfam05128 1173020008835 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1173020008836 hydrophobic ligand binding site; other site 1173020008837 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173020008838 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1173020008839 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173020008840 cystathionine beta-lyase; Region: PLN02509 1173020008841 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1173020008842 oligomeric interface; other site 1173020008843 putative active site [active] 1173020008844 homodimer interface [polypeptide binding]; other site 1173020008845 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173020008846 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1173020008847 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173020008848 catalytic residue [active] 1173020008849 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1173020008850 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1173020008851 homodimer interface [polypeptide binding]; other site 1173020008852 oligonucleotide binding site [chemical binding]; other site 1173020008853 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173020008854 active site 1173020008855 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1173020008856 RNA/DNA hybrid binding site [nucleotide binding]; other site 1173020008857 active site 1173020008858 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 1173020008859 prephenate dehydratase; Provisional; Region: PRK11898 1173020008860 Prephenate dehydratase; Region: PDT; pfam00800 1173020008861 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1173020008862 putative L-Phe binding site [chemical binding]; other site 1173020008863 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173020008864 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1173020008865 active site 1173020008866 cell division protein; Validated; Region: ftsH; CHL00176 1173020008867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020008868 Walker A motif; other site 1173020008869 ATP binding site [chemical binding]; other site 1173020008870 Walker B motif; other site 1173020008871 arginine finger; other site 1173020008872 Peptidase family M41; Region: Peptidase_M41; pfam01434 1173020008873 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1173020008874 Phycobilisome protein; Region: Phycobilisome; cl08227 1173020008875 allophycocyanin beta subunit; Region: apcB; CHL00088 1173020008876 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1173020008877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 1173020008878 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1173020008879 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 1173020008880 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 1173020008881 Ycf27; Reviewed; Region: orf27; CHL00148 1173020008882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020008883 active site 1173020008884 phosphorylation site [posttranslational modification] 1173020008885 intermolecular recognition site; other site 1173020008886 dimerization interface [polypeptide binding]; other site 1173020008887 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020008888 DNA binding site [nucleotide binding] 1173020008889 DNA repair protein RadA; Provisional; Region: PRK11823 1173020008890 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1173020008891 Walker A motif/ATP binding site; other site 1173020008892 ATP binding site [chemical binding]; other site 1173020008893 Walker B motif; other site 1173020008894 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1173020008895 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 1173020008896 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1173020008897 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1173020008898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020008899 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 1173020008900 Walker A motif; other site 1173020008901 ATP binding site [chemical binding]; other site 1173020008902 Walker B motif; other site 1173020008903 arginine finger; other site 1173020008904 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1173020008905 metal ion-dependent adhesion site (MIDAS); other site 1173020008906 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1173020008907 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020008908 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020008909 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020008910 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173020008911 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1173020008912 protein binding site [polypeptide binding]; other site 1173020008913 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1173020008914 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020008915 TPR repeat; Region: TPR_11; pfam13414 1173020008916 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020008917 binding surface 1173020008918 TPR motif; other site 1173020008919 TPR repeat; Region: TPR_11; pfam13414 1173020008920 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020008921 TPR motif; other site 1173020008922 binding surface 1173020008923 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173020008924 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1173020008925 ferrochelatase; Reviewed; Region: hemH; PRK00035 1173020008926 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1173020008927 active site 1173020008928 C-terminal domain interface [polypeptide binding]; other site 1173020008929 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1173020008930 active site 1173020008931 N-terminal domain interface [polypeptide binding]; other site 1173020008932 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 1173020008933 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020008934 binding surface 1173020008935 TPR repeat; Region: TPR_11; pfam13414 1173020008936 TPR motif; other site 1173020008937 TPR repeat; Region: TPR_11; pfam13414 1173020008938 GAF domain; Region: GAF_3; pfam13492 1173020008939 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1173020008940 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1173020008941 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1173020008942 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1173020008943 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1173020008944 P loop; other site 1173020008945 GTP binding site [chemical binding]; other site 1173020008946 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1173020008947 putative RNA binding site [nucleotide binding]; other site 1173020008948 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1173020008949 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020008950 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 1173020008951 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 1173020008952 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1173020008953 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1173020008954 active site 1173020008955 putative substrate binding region [chemical binding]; other site 1173020008956 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1173020008957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 1173020008958 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173020008959 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173020008960 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1173020008961 Walker A/P-loop; other site 1173020008962 ATP binding site [chemical binding]; other site 1173020008963 Q-loop/lid; other site 1173020008964 ABC transporter signature motif; other site 1173020008965 Walker B; other site 1173020008966 D-loop; other site 1173020008967 H-loop/switch region; other site 1173020008968 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1173020008969 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020008970 active site 1173020008971 motif I; other site 1173020008972 motif II; other site 1173020008973 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020008974 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020008975 GAF domain; Region: GAF; pfam01590 1173020008976 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020008977 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020008978 dimer interface [polypeptide binding]; other site 1173020008979 phosphorylation site [posttranslational modification] 1173020008980 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1173020008981 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1173020008982 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1173020008983 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1173020008984 light-harvesting-like protein 3; Provisional; Region: PLN00014 1173020008985 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1173020008986 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1173020008987 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1173020008988 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1173020008989 PemK-like protein; Region: PemK; pfam02452 1173020008990 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1173020008991 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1173020008992 DNA binding residues [nucleotide binding] 1173020008993 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1173020008994 catalytic residues [active] 1173020008995 catalytic nucleophile [active] 1173020008996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173020008997 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173020008998 Probable transposase; Region: OrfB_IS605; pfam01385 1173020008999 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173020009000 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1173020009001 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1173020009002 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1173020009003 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1173020009004 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1173020009005 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1173020009006 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 1173020009007 KTSC domain; Region: KTSC; pfam13619 1173020009008 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1173020009009 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1173020009010 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1173020009011 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1173020009012 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1173020009013 HIGH motif; other site 1173020009014 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1173020009015 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1173020009016 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1173020009017 active site 1173020009018 KMSKS motif; other site 1173020009019 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1173020009020 tRNA binding surface [nucleotide binding]; other site 1173020009021 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1173020009022 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374 1173020009023 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1173020009024 active site 1173020009025 PHP Thumb interface [polypeptide binding]; other site 1173020009026 metal binding site [ion binding]; metal-binding site 1173020009027 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1173020009028 generic binding surface II; other site 1173020009029 generic binding surface I; other site 1173020009030 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173020009031 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020009032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020009033 active site 1173020009034 phosphorylation site [posttranslational modification] 1173020009035 intermolecular recognition site; other site 1173020009036 dimerization interface [polypeptide binding]; other site 1173020009037 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1173020009038 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1173020009039 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1173020009040 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1173020009041 dimerization interface [polypeptide binding]; other site 1173020009042 domain crossover interface; other site 1173020009043 redox-dependent activation switch; other site 1173020009044 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1173020009045 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1173020009046 nudix motif; other site 1173020009047 TPR repeat; Region: TPR_11; pfam13414 1173020009048 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020009049 binding surface 1173020009050 TPR motif; other site 1173020009051 glycogen synthase; Provisional; Region: glgA; PRK00654 1173020009052 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1173020009053 ADP-binding pocket [chemical binding]; other site 1173020009054 homodimer interface [polypeptide binding]; other site 1173020009055 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173020009056 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173020009057 Competence protein; Region: Competence; cl00471 1173020009058 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1173020009059 heme binding pocket [chemical binding]; other site 1173020009060 heme ligand [chemical binding]; other site 1173020009061 Predicted metal-binding protein [Function unknown]; Region: COG5469 1173020009062 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 1173020009063 PRC-barrel domain; Region: PRC; pfam05239 1173020009064 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1173020009065 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1173020009066 DNA binding residues [nucleotide binding] 1173020009067 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1173020009068 catalytic residues [active] 1173020009069 catalytic nucleophile [active] 1173020009070 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1173020009071 amphipathic channel; other site 1173020009072 Asn-Pro-Ala signature motifs; other site 1173020009073 DDE superfamily endonuclease; Region: DDE_5; cl17874 1173020009074 PAS domain; Region: PAS_9; pfam13426 1173020009075 PAS fold; Region: PAS_4; pfam08448 1173020009076 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020009077 putative active site [active] 1173020009078 heme pocket [chemical binding]; other site 1173020009079 PAS fold; Region: PAS_3; pfam08447 1173020009080 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020009081 putative active site [active] 1173020009082 heme pocket [chemical binding]; other site 1173020009083 PAS fold; Region: PAS_4; pfam08448 1173020009084 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020009085 putative active site [active] 1173020009086 heme pocket [chemical binding]; other site 1173020009087 PAS domain S-box; Region: sensory_box; TIGR00229 1173020009088 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020009089 putative active site [active] 1173020009090 heme pocket [chemical binding]; other site 1173020009091 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020009092 dimer interface [polypeptide binding]; other site 1173020009093 phosphorylation site [posttranslational modification] 1173020009094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020009095 Mg2+ binding site [ion binding]; other site 1173020009096 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 1173020009097 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 1173020009098 hydroperoxidase II; Provisional; Region: katE; PRK11249 1173020009099 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1173020009100 tetramer interface [polypeptide binding]; other site 1173020009101 heme binding pocket [chemical binding]; other site 1173020009102 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1173020009103 domain interactions; other site 1173020009104 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 1173020009105 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020009106 Phytochrome region; Region: PHY; pfam00360 1173020009107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020009108 dimer interface [polypeptide binding]; other site 1173020009109 phosphorylation site [posttranslational modification] 1173020009110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020009111 ATP binding site [chemical binding]; other site 1173020009112 Mg2+ binding site [ion binding]; other site 1173020009113 G-X-G motif; other site 1173020009114 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020009115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020009116 active site 1173020009117 phosphorylation site [posttranslational modification] 1173020009118 intermolecular recognition site; other site 1173020009119 dimerization interface [polypeptide binding]; other site 1173020009120 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020009121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020009122 active site 1173020009123 phosphorylation site [posttranslational modification] 1173020009124 intermolecular recognition site; other site 1173020009125 dimerization interface [polypeptide binding]; other site 1173020009126 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020009127 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020009128 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020009129 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020009130 dimer interface [polypeptide binding]; other site 1173020009131 phosphorylation site [posttranslational modification] 1173020009132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020009133 ATP binding site [chemical binding]; other site 1173020009134 Mg2+ binding site [ion binding]; other site 1173020009135 G-X-G motif; other site 1173020009136 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1173020009137 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173020009138 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173020009139 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 1173020009140 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 1173020009141 DALR anticodon binding domain; Region: DALR_1; smart00836 1173020009142 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173020009143 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173020009144 putative switch regulator; other site 1173020009145 non-specific DNA interactions [nucleotide binding]; other site 1173020009146 DNA binding site [nucleotide binding] 1173020009147 sequence specific DNA binding site [nucleotide binding]; other site 1173020009148 putative cAMP binding site [chemical binding]; other site 1173020009149 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 1173020009150 shikimate kinase; Reviewed; Region: aroK; PRK00131 1173020009151 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1173020009152 ADP binding site [chemical binding]; other site 1173020009153 magnesium binding site [ion binding]; other site 1173020009154 putative shikimate binding site; other site 1173020009155 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020009156 putative active site [active] 1173020009157 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173020009158 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173020009159 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1173020009160 Dynamin family; Region: Dynamin_N; pfam00350 1173020009161 G1 box; other site 1173020009162 GTP/Mg2+ binding site [chemical binding]; other site 1173020009163 G2 box; other site 1173020009164 Switch I region; other site 1173020009165 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1173020009166 G3 box; other site 1173020009167 Switch II region; other site 1173020009168 GTP/Mg2+ binding site [chemical binding]; other site 1173020009169 G4 box; other site 1173020009170 G5 box; other site 1173020009171 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1173020009172 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1173020009173 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1173020009174 oligomeric interface; other site 1173020009175 putative active site [active] 1173020009176 homodimer interface [polypeptide binding]; other site 1173020009177 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1173020009178 Dynamin family; Region: Dynamin_N; pfam00350 1173020009179 G1 box; other site 1173020009180 GTP/Mg2+ binding site [chemical binding]; other site 1173020009181 G2 box; other site 1173020009182 Switch I region; other site 1173020009183 G3 box; other site 1173020009184 Switch II region; other site 1173020009185 G4 box; other site 1173020009186 G5 box; other site 1173020009187 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1173020009188 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1173020009189 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 1173020009190 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1173020009191 active site 1173020009192 zinc binding site [ion binding]; other site 1173020009193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020009194 H+ Antiporter protein; Region: 2A0121; TIGR00900 1173020009195 putative substrate translocation pore; other site 1173020009196 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020009197 PAS fold; Region: PAS_3; pfam08447 1173020009198 putative active site [active] 1173020009199 heme pocket [chemical binding]; other site 1173020009200 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020009201 GAF domain; Region: GAF; pfam01590 1173020009202 PAS fold; Region: PAS_4; pfam08448 1173020009203 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020009204 dimer interface [polypeptide binding]; other site 1173020009205 phosphorylation site [posttranslational modification] 1173020009206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020009207 ATP binding site [chemical binding]; other site 1173020009208 Mg2+ binding site [ion binding]; other site 1173020009209 G-X-G motif; other site 1173020009210 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1173020009211 active site residue [active] 1173020009212 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 1173020009213 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020009214 GAF domain; Region: GAF_3; pfam13492 1173020009215 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020009216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020009217 dimer interface [polypeptide binding]; other site 1173020009218 phosphorylation site [posttranslational modification] 1173020009219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020009220 ATP binding site [chemical binding]; other site 1173020009221 Mg2+ binding site [ion binding]; other site 1173020009222 G-X-G motif; other site 1173020009223 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020009224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020009225 active site 1173020009226 phosphorylation site [posttranslational modification] 1173020009227 intermolecular recognition site; other site 1173020009228 dimerization interface [polypeptide binding]; other site 1173020009229 PAS fold; Region: PAS_4; pfam08448 1173020009230 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020009231 putative active site [active] 1173020009232 heme pocket [chemical binding]; other site 1173020009233 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173020009234 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020009235 putative active site [active] 1173020009236 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020009237 heme pocket [chemical binding]; other site 1173020009238 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020009239 dimer interface [polypeptide binding]; other site 1173020009240 phosphorylation site [posttranslational modification] 1173020009241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020009242 ATP binding site [chemical binding]; other site 1173020009243 Mg2+ binding site [ion binding]; other site 1173020009244 G-X-G motif; other site 1173020009245 Repair protein; Region: Repair_PSII; pfam04536 1173020009246 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1173020009247 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1173020009248 HD domain; Region: HD; pfam01966 1173020009249 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 1173020009250 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 1173020009251 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1173020009252 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020009253 putative active site [active] 1173020009254 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1173020009255 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1173020009256 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1173020009257 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1173020009258 rRNA interaction site [nucleotide binding]; other site 1173020009259 S8 interaction site; other site 1173020009260 putative laminin-1 binding site; other site 1173020009261 elongation factor Ts; Provisional; Region: tsf; PRK09377 1173020009262 UBA/TS-N domain; Region: UBA; pfam00627 1173020009263 Elongation factor TS; Region: EF_TS; pfam00889 1173020009264 Elongation factor TS; Region: EF_TS; pfam00889 1173020009265 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1173020009266 Putative addiction module component; Region: Unstab_antitox; pfam09720 1173020009267 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1173020009268 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1173020009269 substrate binding site [chemical binding]; other site 1173020009270 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1173020009271 substrate binding site [chemical binding]; other site 1173020009272 ligand binding site [chemical binding]; other site 1173020009273 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1173020009274 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1173020009275 activation loop (A-loop); other site 1173020009276 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1173020009277 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1173020009278 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1173020009279 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1173020009280 active site 1173020009281 ATP binding site [chemical binding]; other site 1173020009282 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1173020009283 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1173020009284 heme-binding site [chemical binding]; other site 1173020009285 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1173020009286 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1173020009287 active site 1173020009288 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 1173020009289 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 1173020009290 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1173020009291 alpha subunit interface [polypeptide binding]; other site 1173020009292 TPP binding site [chemical binding]; other site 1173020009293 heterodimer interface [polypeptide binding]; other site 1173020009294 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1173020009295 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1173020009296 protein-export membrane protein SecD; Region: secD; TIGR01129 1173020009297 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1173020009298 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1173020009299 Protein export membrane protein; Region: SecD_SecF; pfam02355 1173020009300 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1173020009301 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1173020009302 Cysteine-rich domain; Region: CCG; pfam02754 1173020009303 Cysteine-rich domain; Region: CCG; pfam02754 1173020009304 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173020009305 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 1173020009306 pyruvate kinase; Provisional; Region: PRK06354 1173020009307 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1173020009308 domain interfaces; other site 1173020009309 active site 1173020009310 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1173020009311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020009312 active site 1173020009313 phosphorylation site [posttranslational modification] 1173020009314 intermolecular recognition site; other site 1173020009315 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020009316 dimerization interface [polypeptide binding]; other site 1173020009317 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020009318 dimer interface [polypeptide binding]; other site 1173020009319 phosphorylation site [posttranslational modification] 1173020009320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020009321 ATP binding site [chemical binding]; other site 1173020009322 Mg2+ binding site [ion binding]; other site 1173020009323 G-X-G motif; other site 1173020009324 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020009325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020009326 active site 1173020009327 phosphorylation site [posttranslational modification] 1173020009328 intermolecular recognition site; other site 1173020009329 dimerization interface [polypeptide binding]; other site 1173020009330 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020009331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020009332 active site 1173020009333 phosphorylation site [posttranslational modification] 1173020009334 intermolecular recognition site; other site 1173020009335 dimerization interface [polypeptide binding]; other site 1173020009336 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1173020009337 active site 1173020009338 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 1173020009339 active site 1173020009340 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173020009341 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173020009342 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1173020009343 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1173020009344 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1173020009345 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020009346 putative active site [active] 1173020009347 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1173020009348 catalytic triad [active] 1173020009349 conserved cis-peptide bond; other site 1173020009350 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1173020009351 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1173020009352 Walker A/P-loop; other site 1173020009353 ATP binding site [chemical binding]; other site 1173020009354 Q-loop/lid; other site 1173020009355 ABC transporter signature motif; other site 1173020009356 Walker B; other site 1173020009357 D-loop; other site 1173020009358 H-loop/switch region; other site 1173020009359 TOBE domain; Region: TOBE_2; pfam08402 1173020009360 Protein of unknown function (DUF1517); Region: DUF1517; pfam07466 1173020009361 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020009362 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020009363 dimer interface [polypeptide binding]; other site 1173020009364 phosphorylation site [posttranslational modification] 1173020009365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020009366 ATP binding site [chemical binding]; other site 1173020009367 Mg2+ binding site [ion binding]; other site 1173020009368 G-X-G motif; other site 1173020009369 HEAT repeats; Region: HEAT_2; pfam13646 1173020009370 HEAT repeats; Region: HEAT_2; pfam13646 1173020009371 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1173020009372 HEAT repeats; Region: HEAT_2; pfam13646 1173020009373 CpeS-like protein; Region: CpeS; pfam09367 1173020009374 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1173020009375 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1173020009376 putative di-iron ligands [ion binding]; other site 1173020009377 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1173020009378 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173020009379 catalytic triad [active] 1173020009380 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1173020009381 active site 1173020009382 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1173020009383 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1173020009384 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173020009385 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1173020009386 protein binding site [polypeptide binding]; other site 1173020009387 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 1173020009388 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 1173020009389 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 1173020009390 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1173020009391 active site 1173020009392 catalytic residues [active] 1173020009393 PBP superfamily domain; Region: PBP_like_2; cl17296 1173020009394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020009395 putative substrate translocation pore; other site 1173020009396 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173020009397 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 1173020009398 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1173020009399 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1173020009400 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173020009401 dimerization interface [polypeptide binding]; other site 1173020009402 putative DNA binding site [nucleotide binding]; other site 1173020009403 putative Zn2+ binding site [ion binding]; other site 1173020009404 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1173020009405 amphipathic channel; other site 1173020009406 Asn-Pro-Ala signature motifs; other site 1173020009407 Leucine rich repeat; Region: LRR_8; pfam13855 1173020009408 Leucine rich repeat; Region: LRR_8; pfam13855 1173020009409 Leucine rich repeat; Region: LRR_8; pfam13855 1173020009410 Leucine rich repeat; Region: LRR_8; pfam13855 1173020009411 Leucine rich repeat; Region: LRR_8; pfam13855 1173020009412 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1173020009413 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1173020009414 phosphodiesterase YaeI; Provisional; Region: PRK11340 1173020009415 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1173020009416 putative active site [active] 1173020009417 putative metal binding site [ion binding]; other site 1173020009418 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020009419 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020009420 dimer interface [polypeptide binding]; other site 1173020009421 phosphorylation site [posttranslational modification] 1173020009422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020009423 ATP binding site [chemical binding]; other site 1173020009424 Mg2+ binding site [ion binding]; other site 1173020009425 G-X-G motif; other site 1173020009426 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1173020009427 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1173020009428 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173020009429 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1173020009430 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1173020009431 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020009432 histidinol-phosphate aminotransferase; Provisional; Region: PRK02610 1173020009433 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173020009434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020009435 homodimer interface [polypeptide binding]; other site 1173020009436 catalytic residue [active] 1173020009437 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1173020009438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020009439 S-adenosylmethionine binding site [chemical binding]; other site 1173020009440 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 1173020009441 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1173020009442 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173020009443 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 1173020009444 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 1173020009445 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020009446 TPR motif; other site 1173020009447 binding surface 1173020009448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020009449 TPR motif; other site 1173020009450 binding surface 1173020009451 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020009452 binding surface 1173020009453 TPR motif; other site 1173020009454 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1173020009455 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020009456 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 1173020009457 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1173020009458 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1173020009459 dinuclear metal binding motif [ion binding]; other site 1173020009460 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 1173020009461 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173020009462 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173020009463 DNA binding residues [nucleotide binding] 1173020009464 Transcriptional activator [Transcription]; Region: ChrR; COG3806 1173020009465 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1173020009466 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1173020009467 putative active site [active] 1173020009468 transaldolase; Provisional; Region: PRK03903 1173020009469 catalytic residue [active] 1173020009470 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1173020009471 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1173020009472 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1173020009473 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173020009474 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1173020009475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1173020009476 Protein of unknown function (DUF433); Region: DUF433; pfam04255 1173020009477 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1173020009478 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1173020009479 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1173020009480 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1173020009481 RNA binding site [nucleotide binding]; other site 1173020009482 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1173020009483 histidinol dehydrogenase; Region: hisD; TIGR00069 1173020009484 NAD binding site [chemical binding]; other site 1173020009485 dimerization interface [polypeptide binding]; other site 1173020009486 product binding site; other site 1173020009487 substrate binding site [chemical binding]; other site 1173020009488 zinc binding site [ion binding]; other site 1173020009489 catalytic residues [active] 1173020009490 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1173020009491 dimer interface [polypeptide binding]; other site 1173020009492 motif 1; other site 1173020009493 active site 1173020009494 motif 2; other site 1173020009495 motif 3; other site 1173020009496 Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468 1173020009497 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 1173020009498 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1173020009499 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173020009500 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020009501 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020009502 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020009503 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1173020009504 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020009505 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020009506 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1173020009507 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020009508 putative active site [active] 1173020009509 heme pocket [chemical binding]; other site 1173020009510 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020009511 dimer interface [polypeptide binding]; other site 1173020009512 phosphorylation site [posttranslational modification] 1173020009513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020009514 ATP binding site [chemical binding]; other site 1173020009515 Mg2+ binding site [ion binding]; other site 1173020009516 G-X-G motif; other site 1173020009517 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020009518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020009519 active site 1173020009520 phosphorylation site [posttranslational modification] 1173020009521 intermolecular recognition site; other site 1173020009522 dimerization interface [polypeptide binding]; other site 1173020009523 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020009524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020009525 active site 1173020009526 phosphorylation site [posttranslational modification] 1173020009527 intermolecular recognition site; other site 1173020009528 dimerization interface [polypeptide binding]; other site 1173020009529 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020009530 DNA binding site [nucleotide binding] 1173020009531 Hpt domain; Region: Hpt; pfam01627 1173020009532 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020009533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020009534 active site 1173020009535 phosphorylation site [posttranslational modification] 1173020009536 intermolecular recognition site; other site 1173020009537 dimerization interface [polypeptide binding]; other site 1173020009538 HEAT repeats; Region: HEAT_2; pfam13646 1173020009539 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 1173020009540 protein binding surface [polypeptide binding]; other site 1173020009541 HEAT repeats; Region: HEAT_2; pfam13646 1173020009542 HEAT repeats; Region: HEAT_2; pfam13646 1173020009543 HEAT repeats; Region: HEAT_2; pfam13646 1173020009544 HEAT repeats; Region: HEAT_2; pfam13646 1173020009545 Phycobilisome protein; Region: Phycobilisome; cl08227 1173020009546 Phycobilisome protein; Region: Phycobilisome; cl08227 1173020009547 HEAT repeats; Region: HEAT_2; pfam13646 1173020009548 HEAT repeats; Region: HEAT_2; pfam13646 1173020009549 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 1173020009550 Phycobilisome protein; Region: Phycobilisome; cl08227 1173020009551 CpeS-like protein; Region: CpeS; pfam09367 1173020009552 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020009553 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020009554 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020009555 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020009556 Protein of unknown function (DUF2656); Region: DUF2656; pfam10847 1173020009557 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173020009558 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1173020009559 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173020009560 CpcD/allophycocyanin linker domain; Region: CpcD; smart01094 1173020009561 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173020009562 CpcD/allophycocyanin linker domain; Region: CpcD; smart01094 1173020009563 CpcD/allophycocyanin linker domain; Region: CpcD; smart01094 1173020009564 CpeS-like protein; Region: CpeS; pfam09367 1173020009565 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 1173020009566 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 1173020009567 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 1173020009568 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 1173020009569 Phycobilisome protein; Region: Phycobilisome; cl08227 1173020009570 Phycobilisome protein; Region: Phycobilisome; cl08227 1173020009571 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173020009572 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1173020009573 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173020009574 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1173020009575 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1173020009576 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1173020009577 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1173020009578 cobalamin binding residues [chemical binding]; other site 1173020009579 putative BtuC binding residues; other site 1173020009580 dimer interface [polypeptide binding]; other site 1173020009581 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 1173020009582 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1173020009583 pseudouridine synthase; Region: TIGR00093 1173020009584 active site 1173020009585 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1173020009586 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173020009587 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1173020009588 dimerization interface [polypeptide binding]; other site 1173020009589 substrate binding pocket [chemical binding]; other site 1173020009590 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020009591 Walker A/P-loop; other site 1173020009592 ATP binding site [chemical binding]; other site 1173020009593 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 1173020009594 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1173020009595 ligand binding site; other site 1173020009596 oligomer interface; other site 1173020009597 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173020009598 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173020009599 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1173020009600 dimer interface [polypeptide binding]; other site 1173020009601 N-terminal domain interface [polypeptide binding]; other site 1173020009602 sulfate 1 binding site; other site 1173020009603 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1173020009604 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173020009605 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173020009606 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1173020009607 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1173020009608 trimer interface [polypeptide binding]; other site 1173020009609 active site 1173020009610 substrate binding site [chemical binding]; other site 1173020009611 CoA binding site [chemical binding]; other site 1173020009612 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1173020009613 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020009614 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020009615 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020009616 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 1173020009617 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173020009618 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173020009619 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1173020009620 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 1173020009621 WD40 repeats; Region: WD40; smart00320 1173020009622 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020009623 structural tetrad; other site 1173020009624 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020009625 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020009626 structural tetrad; other site 1173020009627 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1173020009628 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173020009629 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 1173020009630 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 1173020009631 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 1173020009632 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1173020009633 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1173020009634 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1173020009635 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1173020009636 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 1173020009637 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 1173020009638 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1173020009639 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1173020009640 NAD(P) binding site [chemical binding]; other site 1173020009641 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1173020009642 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1173020009643 Cupin superfamily protein; Region: Cupin_4; pfam08007 1173020009644 Cupin-like domain; Region: Cupin_8; pfam13621 1173020009645 Domain of unknown function (DUF4135); Region: DUF4135; pfam13575 1173020009646 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173020009647 bacteriocin-type transport-associated protein; Region: cyc_nuc_ocin; TIGR03896 1173020009648 ligand binding site [chemical binding]; other site 1173020009649 flexible hinge region; other site 1173020009650 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173020009651 ligand binding site [chemical binding]; other site 1173020009652 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 1173020009653 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1173020009654 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173020009655 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 1173020009656 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1173020009657 putative active site [active] 1173020009658 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173020009659 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020009660 Walker A/P-loop; other site 1173020009661 ATP binding site [chemical binding]; other site 1173020009662 Q-loop/lid; other site 1173020009663 ABC transporter signature motif; other site 1173020009664 Walker B; other site 1173020009665 D-loop; other site 1173020009666 H-loop/switch region; other site 1173020009667 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 1173020009668 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020009669 Walker A/P-loop; other site 1173020009670 ATP binding site [chemical binding]; other site 1173020009671 Q-loop/lid; other site 1173020009672 ABC transporter signature motif; other site 1173020009673 Walker B; other site 1173020009674 D-loop; other site 1173020009675 H-loop/switch region; other site 1173020009676 Protein of unknown function (DUF98); Region: DUF98; pfam01947 1173020009677 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1173020009678 RibD C-terminal domain; Region: RibD_C; cl17279 1173020009679 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1173020009680 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1173020009681 substrate binding pocket [chemical binding]; other site 1173020009682 chain length determination region; other site 1173020009683 substrate-Mg2+ binding site; other site 1173020009684 catalytic residues [active] 1173020009685 aspartate-rich region 1; other site 1173020009686 active site lid residues [active] 1173020009687 aspartate-rich region 2; other site 1173020009688 glutamate racemase; Provisional; Region: PRK00865 1173020009689 AMIN domain; Region: AMIN; pfam11741 1173020009690 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1173020009691 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1173020009692 active site 1173020009693 metal binding site [ion binding]; metal-binding site 1173020009694 AMIN domain; Region: AMIN; pfam11741 1173020009695 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1173020009696 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1173020009697 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020009698 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1173020009699 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1173020009700 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1173020009701 active site 1173020009702 catalytic residues [active] 1173020009703 DNA binding site [nucleotide binding] 1173020009704 Int/Topo IB signature motif; other site 1173020009705 light-harvesting-like protein 3; Provisional; Region: PLN00014 1173020009706 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 1173020009707 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1173020009708 diaminopimelate epimerase; Region: PLN02536 1173020009709 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1173020009710 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1173020009711 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1173020009712 Walker A/P-loop; other site 1173020009713 ATP binding site [chemical binding]; other site 1173020009714 Q-loop/lid; other site 1173020009715 ABC transporter signature motif; other site 1173020009716 Walker B; other site 1173020009717 D-loop; other site 1173020009718 H-loop/switch region; other site 1173020009719 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1173020009720 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1173020009721 catalytic residues [active] 1173020009722 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173020009723 putative binding surface; other site 1173020009724 active site 1173020009725 Protein of unknown function (DUF2396); Region: DUF2396; pfam09654 1173020009726 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1173020009727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020009728 dimer interface [polypeptide binding]; other site 1173020009729 conserved gate region; other site 1173020009730 putative PBP binding loops; other site 1173020009731 ABC-ATPase subunit interface; other site 1173020009732 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1173020009733 dinuclear metal binding motif [ion binding]; other site 1173020009734 AAA ATPase domain; Region: AAA_16; pfam13191 1173020009735 NACHT domain; Region: NACHT; pfam05729 1173020009736 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020009737 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020009738 structural tetrad; other site 1173020009739 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020009740 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020009741 structural tetrad; other site 1173020009742 MoxR-like ATPases [General function prediction only]; Region: COG0714 1173020009743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020009744 Walker A motif; other site 1173020009745 ATP binding site [chemical binding]; other site 1173020009746 Walker B motif; other site 1173020009747 arginine finger; other site 1173020009748 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1173020009749 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 1173020009750 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173020009751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020009752 homodimer interface [polypeptide binding]; other site 1173020009753 catalytic residue [active] 1173020009754 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1173020009755 Aspartase; Region: Aspartase; cd01357 1173020009756 active sites [active] 1173020009757 tetramer interface [polypeptide binding]; other site 1173020009758 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 1173020009759 protein I interface; other site 1173020009760 D2 interface; other site 1173020009761 protein T interface; other site 1173020009762 chlorophyll binding site; other site 1173020009763 beta carotene binding site; other site 1173020009764 pheophytin binding site; other site 1173020009765 manganese-stabilizing polypeptide interface; other site 1173020009766 CP43 interface; other site 1173020009767 protein L interface; other site 1173020009768 oxygen evolving complex binding site; other site 1173020009769 bromide binding site; other site 1173020009770 quinone binding site; other site 1173020009771 Fe binding site [ion binding]; other site 1173020009772 core light harvesting interface; other site 1173020009773 cytochrome b559 alpha subunit interface; other site 1173020009774 cytochrome c-550 interface; other site 1173020009775 protein J interface; other site 1173020009776 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1173020009777 nucleotide binding site/active site [active] 1173020009778 HIT family signature motif; other site 1173020009779 catalytic residue [active] 1173020009780 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 1173020009781 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 1173020009782 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 1173020009783 argininosuccinate synthase; Provisional; Region: PRK13820 1173020009784 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1173020009785 ANP binding site [chemical binding]; other site 1173020009786 Substrate Binding Site II [chemical binding]; other site 1173020009787 Substrate Binding Site I [chemical binding]; other site 1173020009788 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 1173020009789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020009790 binding surface 1173020009791 TPR motif; other site 1173020009792 TPR repeat; Region: TPR_11; pfam13414 1173020009793 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020009794 TPR repeat; Region: TPR_11; pfam13414 1173020009795 binding surface 1173020009796 TPR motif; other site 1173020009797 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1173020009798 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1173020009799 dimer interface [polypeptide binding]; other site 1173020009800 motif 1; other site 1173020009801 active site 1173020009802 motif 2; other site 1173020009803 motif 3; other site 1173020009804 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173020009805 HSP70 interaction site [polypeptide binding]; other site 1173020009806 TPR repeat; Region: TPR_11; pfam13414 1173020009807 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020009808 binding surface 1173020009809 TPR motif; other site 1173020009810 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1173020009811 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1173020009812 active site 1173020009813 dimerization interface [polypeptide binding]; other site 1173020009814 ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165 1173020009815 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1173020009816 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1173020009817 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1173020009818 metal binding site [ion binding]; metal-binding site 1173020009819 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1173020009820 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1173020009821 putative catalytic cysteine [active] 1173020009822 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 1173020009823 Ycf46; Provisional; Region: ycf46; CHL00195 1173020009824 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020009825 Walker A motif; other site 1173020009826 ATP binding site [chemical binding]; other site 1173020009827 Walker B motif; other site 1173020009828 arginine finger; other site 1173020009829 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173020009830 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1173020009831 active site 1173020009832 metal binding site [ion binding]; metal-binding site 1173020009833 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1173020009834 hypothetical protein; Reviewed; Region: PRK09588 1173020009835 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 1173020009836 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1173020009837 Peptidase family M50; Region: Peptidase_M50; pfam02163 1173020009838 active site 1173020009839 putative substrate binding region [chemical binding]; other site 1173020009840 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020009841 binding surface 1173020009842 TPR motif; other site 1173020009843 TPR repeat; Region: TPR_11; pfam13414 1173020009844 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020009845 binding surface 1173020009846 TPR motif; other site 1173020009847 TPR repeat; Region: TPR_11; pfam13414 1173020009848 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173020009849 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1173020009850 putative acyl-acceptor binding pocket; other site 1173020009851 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1173020009852 putative active site [active] 1173020009853 Protein of unknown function (DUF2281); Region: DUF2281; pfam10047 1173020009854 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1173020009855 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1173020009856 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1173020009857 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1173020009858 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1173020009859 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020009860 Leucine rich repeat; Region: LRR_8; pfam13855 1173020009861 Leucine rich repeat; Region: LRR_8; pfam13855 1173020009862 Leucine rich repeat; Region: LRR_8; pfam13855 1173020009863 Leucine rich repeat; Region: LRR_8; pfam13855 1173020009864 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 1173020009865 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 1173020009866 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1173020009867 G1 box; other site 1173020009868 GTP/Mg2+ binding site [chemical binding]; other site 1173020009869 G2 box; other site 1173020009870 Switch I region; other site 1173020009871 G3 box; other site 1173020009872 Switch II region; other site 1173020009873 G4 box; other site 1173020009874 G5 box; other site 1173020009875 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 1173020009876 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1173020009877 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173020009878 ATP binding site [chemical binding]; other site 1173020009879 putative Mg++ binding site [ion binding]; other site 1173020009880 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1173020009881 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020009882 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020009883 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020009884 Integrase core domain; Region: rve; pfam00665 1173020009885 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1173020009886 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1173020009887 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173020009888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020009889 S-adenosylmethionine binding site [chemical binding]; other site 1173020009890 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241 1173020009891 RDD family; Region: RDD; pfam06271 1173020009892 RIP metalloprotease RseP; Region: TIGR00054 1173020009893 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1173020009894 active site 1173020009895 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1173020009896 protein binding site [polypeptide binding]; other site 1173020009897 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1173020009898 putative substrate binding region [chemical binding]; other site 1173020009899 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173020009900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020009901 S-adenosylmethionine binding site [chemical binding]; other site 1173020009902 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1173020009903 16S/18S rRNA binding site [nucleotide binding]; other site 1173020009904 S13e-L30e interaction site [polypeptide binding]; other site 1173020009905 25S rRNA binding site [nucleotide binding]; other site 1173020009906 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 1173020009907 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1173020009908 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461 1173020009909 active site 1173020009910 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1173020009911 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1173020009912 dimerization interface [polypeptide binding]; other site 1173020009913 DPS ferroxidase diiron center [ion binding]; other site 1173020009914 ion pore; other site 1173020009915 ChaB; Region: ChaB; cl01887 1173020009916 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1173020009917 PRC-barrel domain; Region: PRC; pfam05239 1173020009918 PRC-barrel domain; Region: PRC; pfam05239 1173020009919 Domain of unknown function (DUF1832); Region: DUF1832; pfam08870 1173020009920 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1173020009921 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1173020009922 homotetramer interface [polypeptide binding]; other site 1173020009923 FMN binding site [chemical binding]; other site 1173020009924 homodimer contacts [polypeptide binding]; other site 1173020009925 putative active site [active] 1173020009926 putative substrate binding site [chemical binding]; other site 1173020009927 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 1173020009928 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1173020009929 tandem repeat interface [polypeptide binding]; other site 1173020009930 oligomer interface [polypeptide binding]; other site 1173020009931 active site residues [active] 1173020009932 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1173020009933 tandem repeat interface [polypeptide binding]; other site 1173020009934 oligomer interface [polypeptide binding]; other site 1173020009935 active site residues [active] 1173020009936 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1173020009937 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1173020009938 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1173020009939 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1173020009940 tartrate dehydrogenase; Region: TTC; TIGR02089 1173020009941 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 1173020009942 G1 box; other site 1173020009943 GTP/Mg2+ binding site [chemical binding]; other site 1173020009944 G2 box; other site 1173020009945 Switch I region; other site 1173020009946 G3 box; other site 1173020009947 Switch II region; other site 1173020009948 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1173020009949 Protein kinase domain; Region: Pkinase; pfam00069 1173020009950 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020009951 active site 1173020009952 ATP binding site [chemical binding]; other site 1173020009953 substrate binding site [chemical binding]; other site 1173020009954 activation loop (A-loop); other site 1173020009955 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1173020009956 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1173020009957 putative NAD(P) binding site [chemical binding]; other site 1173020009958 active site 1173020009959 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1173020009960 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 1173020009961 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1173020009962 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020009963 binding surface 1173020009964 TPR repeat; Region: TPR_11; pfam13414 1173020009965 TPR motif; other site 1173020009966 TPR repeat; Region: TPR_11; pfam13414 1173020009967 TPR repeat; Region: TPR_11; pfam13414 1173020009968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020009969 binding surface 1173020009970 TPR motif; other site 1173020009971 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020009972 binding surface 1173020009973 TPR motif; other site 1173020009974 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173020009975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020009976 binding surface 1173020009977 TPR motif; other site 1173020009978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020009979 binding surface 1173020009980 TPR motif; other site 1173020009981 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1173020009982 dimer interface [polypeptide binding]; other site 1173020009983 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1173020009984 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 1173020009985 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020009986 binding surface 1173020009987 TPR motif; other site 1173020009988 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020009989 binding surface 1173020009990 TPR repeat; Region: TPR_11; pfam13414 1173020009991 TPR motif; other site 1173020009992 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1173020009993 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1173020009994 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1173020009995 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1173020009996 nucleotide binding site [chemical binding]; other site 1173020009997 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1173020009998 SBD interface [polypeptide binding]; other site 1173020009999 CHASE2 domain; Region: CHASE2; pfam05226 1173020010000 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173020010001 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020010002 dimer interface [polypeptide binding]; other site 1173020010003 phosphorylation site [posttranslational modification] 1173020010004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020010005 ATP binding site [chemical binding]; other site 1173020010006 Mg2+ binding site [ion binding]; other site 1173020010007 G-X-G motif; other site 1173020010008 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020010009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020010010 active site 1173020010011 phosphorylation site [posttranslational modification] 1173020010012 intermolecular recognition site; other site 1173020010013 dimerization interface [polypeptide binding]; other site 1173020010014 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173020010015 putative binding surface; other site 1173020010016 active site 1173020010017 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1173020010018 active site 1173020010019 dimer interface [polypeptide binding]; other site 1173020010020 metal binding site [ion binding]; metal-binding site 1173020010021 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1173020010022 nitrilase; Region: PLN02798 1173020010023 putative active site [active] 1173020010024 catalytic triad [active] 1173020010025 dimer interface [polypeptide binding]; other site 1173020010026 YGGT family; Region: YGGT; pfam02325 1173020010027 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1173020010028 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173020010029 active site 1173020010030 Predicted membrane protein [Function unknown]; Region: COG1981 1173020010031 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1173020010032 putative active site [active] 1173020010033 catalytic residue [active] 1173020010034 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1173020010035 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1173020010036 RNase E interface [polypeptide binding]; other site 1173020010037 trimer interface [polypeptide binding]; other site 1173020010038 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1173020010039 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1173020010040 RNase E interface [polypeptide binding]; other site 1173020010041 trimer interface [polypeptide binding]; other site 1173020010042 active site 1173020010043 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1173020010044 putative nucleic acid binding region [nucleotide binding]; other site 1173020010045 G-X-X-G motif; other site 1173020010046 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1173020010047 RNA binding site [nucleotide binding]; other site 1173020010048 domain interface; other site 1173020010049 Leucine rich repeat; Region: LRR_8; pfam13855 1173020010050 Leucine rich repeat; Region: LRR_8; pfam13855 1173020010051 Leucine rich repeat; Region: LRR_8; pfam13855 1173020010052 PemK-like protein; Region: PemK; pfam02452 1173020010053 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1173020010054 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 1173020010055 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1173020010056 active site 1173020010057 dimer interface [polypeptide binding]; other site 1173020010058 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1173020010059 dimer interface [polypeptide binding]; other site 1173020010060 active site 1173020010061 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020010062 putative active site [active] 1173020010063 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1173020010064 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1173020010065 Restriction endonuclease; Region: Mrr_cat; pfam04471 1173020010066 DNA gyrase subunit A; Validated; Region: PRK05560 1173020010067 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1173020010068 CAP-like domain; other site 1173020010069 active site 1173020010070 primary dimer interface [polypeptide binding]; other site 1173020010071 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173020010072 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173020010073 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173020010074 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173020010075 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173020010076 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173020010077 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1173020010078 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1173020010079 trimer interface [polypeptide binding]; other site 1173020010080 active site 1173020010081 substrate binding site [chemical binding]; other site 1173020010082 CoA binding site [chemical binding]; other site 1173020010083 Protein of unknown function (DUF561); Region: DUF561; pfam04481 1173020010084 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 1173020010085 Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449 1173020010086 TPR repeat; Region: TPR_11; pfam13414 1173020010087 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010088 TPR motif; other site 1173020010089 TPR repeat; Region: TPR_11; pfam13414 1173020010090 binding surface 1173020010091 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1173020010092 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1173020010093 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1173020010094 putative di-iron ligands [ion binding]; other site 1173020010095 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1173020010096 putative active site pocket [active] 1173020010097 dimerization interface [polypeptide binding]; other site 1173020010098 putative catalytic residue [active] 1173020010099 DNA-directed RNA polymerase subunit omega; Provisional; Region: ycf61; CHL00191 1173020010100 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 1173020010101 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1173020010102 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1173020010103 active site 1173020010104 Na/Ca binding site [ion binding]; other site 1173020010105 catalytic site [active] 1173020010106 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 1173020010107 threonine dehydratase; Reviewed; Region: PRK09224 1173020010108 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1173020010109 tetramer interface [polypeptide binding]; other site 1173020010110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020010111 catalytic residue [active] 1173020010112 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1173020010113 putative Ile/Val binding site [chemical binding]; other site 1173020010114 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1173020010115 putative Ile/Val binding site [chemical binding]; other site 1173020010116 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020010117 dimer interface [polypeptide binding]; other site 1173020010118 phosphorylation site [posttranslational modification] 1173020010119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020010120 ATP binding site [chemical binding]; other site 1173020010121 Mg2+ binding site [ion binding]; other site 1173020010122 G-X-G motif; other site 1173020010123 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020010124 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173020010125 Caspase domain; Region: Peptidase_C14; pfam00656 1173020010126 CheW-like domain; Region: CheW; pfam01584 1173020010127 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 1173020010128 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 1173020010129 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173020010130 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020010131 active site 1173020010132 ATP binding site [chemical binding]; other site 1173020010133 substrate binding site [chemical binding]; other site 1173020010134 activation loop (A-loop); other site 1173020010135 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 1173020010136 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1173020010137 elongation factor Tu; Region: tufA; CHL00071 1173020010138 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1173020010139 G1 box; other site 1173020010140 GEF interaction site [polypeptide binding]; other site 1173020010141 GTP/Mg2+ binding site [chemical binding]; other site 1173020010142 Switch I region; other site 1173020010143 G2 box; other site 1173020010144 G3 box; other site 1173020010145 Switch II region; other site 1173020010146 G4 box; other site 1173020010147 G5 box; other site 1173020010148 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1173020010149 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1173020010150 Antibiotic Binding Site [chemical binding]; other site 1173020010151 elongation factor G; Reviewed; Region: PRK00007 1173020010152 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1173020010153 G1 box; other site 1173020010154 putative GEF interaction site [polypeptide binding]; other site 1173020010155 GTP/Mg2+ binding site [chemical binding]; other site 1173020010156 Switch I region; other site 1173020010157 G2 box; other site 1173020010158 G3 box; other site 1173020010159 Switch II region; other site 1173020010160 G4 box; other site 1173020010161 G5 box; other site 1173020010162 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1173020010163 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1173020010164 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1173020010165 30S ribosomal protein S7; Validated; Region: PRK05302 1173020010166 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1173020010167 S17 interaction site [polypeptide binding]; other site 1173020010168 S8 interaction site; other site 1173020010169 16S rRNA interaction site [nucleotide binding]; other site 1173020010170 streptomycin interaction site [chemical binding]; other site 1173020010171 23S rRNA interaction site [nucleotide binding]; other site 1173020010172 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1173020010173 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1173020010174 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173020010175 FeS/SAM binding site; other site 1173020010176 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1173020010177 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1173020010178 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 1173020010179 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1173020010180 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1173020010181 putative active site [active] 1173020010182 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1173020010183 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1173020010184 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1173020010185 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1173020010186 active site 1173020010187 dimer interface [polypeptide binding]; other site 1173020010188 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173020010189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020010190 active site 1173020010191 phosphorylation site [posttranslational modification] 1173020010192 intermolecular recognition site; other site 1173020010193 dimerization interface [polypeptide binding]; other site 1173020010194 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173020010195 DNA binding residues [nucleotide binding] 1173020010196 dimerization interface [polypeptide binding]; other site 1173020010197 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1173020010198 Clp amino terminal domain; Region: Clp_N; pfam02861 1173020010199 Clp amino terminal domain; Region: Clp_N; pfam02861 1173020010200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020010201 Walker A motif; other site 1173020010202 ATP binding site [chemical binding]; other site 1173020010203 Walker B motif; other site 1173020010204 arginine finger; other site 1173020010205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020010206 Walker A motif; other site 1173020010207 ATP binding site [chemical binding]; other site 1173020010208 Walker B motif; other site 1173020010209 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1173020010210 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173020010211 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020010212 Coenzyme A binding pocket [chemical binding]; other site 1173020010213 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1173020010214 ligand binding site [chemical binding]; other site 1173020010215 active site 1173020010216 UGI interface [polypeptide binding]; other site 1173020010217 catalytic site [active] 1173020010218 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1173020010219 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1173020010220 glutamine binding [chemical binding]; other site 1173020010221 catalytic triad [active] 1173020010222 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1173020010223 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 1173020010224 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 1173020010225 primosome assembly protein PriA; Validated; Region: PRK05580 1173020010226 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173020010227 ATP binding site [chemical binding]; other site 1173020010228 putative Mg++ binding site [ion binding]; other site 1173020010229 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1173020010230 ATP-binding site [chemical binding]; other site 1173020010231 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1173020010232 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173020010233 active site 1173020010234 CHAD domain; Region: CHAD; cl10506 1173020010235 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 1173020010236 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1173020010237 Uncharacterized conserved protein [Function unknown]; Region: COG4715 1173020010238 SWIM zinc finger; Region: SWIM; pfam04434 1173020010239 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 1173020010240 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 1173020010241 dimer interface [polypeptide binding]; other site 1173020010242 active site 1173020010243 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1173020010244 catalytic residues [active] 1173020010245 substrate binding site [chemical binding]; other site 1173020010246 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1173020010247 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1173020010248 quinone interaction residues [chemical binding]; other site 1173020010249 active site 1173020010250 catalytic residues [active] 1173020010251 FMN binding site [chemical binding]; other site 1173020010252 substrate binding site [chemical binding]; other site 1173020010253 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1173020010254 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1173020010255 molybdopterin cofactor binding site; other site 1173020010256 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1173020010257 molybdopterin cofactor binding site; other site 1173020010258 PemK-like protein; Region: PemK; pfam02452 1173020010259 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1173020010260 PIN domain; Region: PIN_3; pfam13470 1173020010261 Helix-turn-helix domain; Region: HTH_17; cl17695 1173020010262 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1173020010263 MutS domain I; Region: MutS_I; pfam01624 1173020010264 MutS domain II; Region: MutS_II; pfam05188 1173020010265 MutS domain III; Region: MutS_III; pfam05192 1173020010266 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1173020010267 Walker A/P-loop; other site 1173020010268 ATP binding site [chemical binding]; other site 1173020010269 Q-loop/lid; other site 1173020010270 ABC transporter signature motif; other site 1173020010271 Walker B; other site 1173020010272 D-loop; other site 1173020010273 H-loop/switch region; other site 1173020010274 Predicted integral membrane protein [Function unknown]; Region: COG3548 1173020010275 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1173020010276 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173020010277 TPR repeat; Region: TPR_11; pfam13414 1173020010278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010279 binding surface 1173020010280 TPR motif; other site 1173020010281 TPR repeat; Region: TPR_11; pfam13414 1173020010282 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010283 TPR motif; other site 1173020010284 binding surface 1173020010285 TPR repeat; Region: TPR_11; pfam13414 1173020010286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010287 binding surface 1173020010288 TPR repeat; Region: TPR_11; pfam13414 1173020010289 TPR motif; other site 1173020010290 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1173020010291 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1173020010292 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173020010293 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173020010294 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1173020010295 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 1173020010296 active site 1173020010297 substrate binding site [chemical binding]; other site 1173020010298 cosubstrate binding site; other site 1173020010299 catalytic site [active] 1173020010300 C-terminal subdomain of the Formyltransferase-like domain found in OzmH-like proteins; Region: FMT_C_OzmH_like; cd08700 1173020010301 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1173020010302 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1173020010303 acyl-activating enzyme (AAE) consensus motif; other site 1173020010304 AMP binding site [chemical binding]; other site 1173020010305 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173020010306 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1173020010307 Uncharacterized conserved protein [Function unknown]; Region: COG3937 1173020010308 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173020010309 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1173020010310 P-loop; other site 1173020010311 Magnesium ion binding site [ion binding]; other site 1173020010312 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020010313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020010314 active site 1173020010315 phosphorylation site [posttranslational modification] 1173020010316 intermolecular recognition site; other site 1173020010317 Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219 1173020010318 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1173020010319 active site 1173020010320 ATP binding site [chemical binding]; other site 1173020010321 substrate binding site [chemical binding]; other site 1173020010322 activation loop (A-loop); other site 1173020010323 AAA ATPase domain; Region: AAA_16; pfam13191 1173020010324 Predicted ATPase [General function prediction only]; Region: COG3899 1173020010325 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020010326 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020010327 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020010328 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020010329 dimer interface [polypeptide binding]; other site 1173020010330 phosphorylation site [posttranslational modification] 1173020010331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020010332 ATP binding site [chemical binding]; other site 1173020010333 Mg2+ binding site [ion binding]; other site 1173020010334 G-X-G motif; other site 1173020010335 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020010336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020010337 active site 1173020010338 phosphorylation site [posttranslational modification] 1173020010339 intermolecular recognition site; other site 1173020010340 dimerization interface [polypeptide binding]; other site 1173020010341 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173020010342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020010343 S-adenosylmethionine binding site [chemical binding]; other site 1173020010344 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1173020010345 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173020010346 aromatic prenyltransferase, DMATS type; Region: arom_pren_DMATS; TIGR03429 1173020010347 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1173020010348 FOG: CBS domain [General function prediction only]; Region: COG0517 1173020010349 PAS fold; Region: PAS_4; pfam08448 1173020010350 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020010351 putative active site [active] 1173020010352 heme pocket [chemical binding]; other site 1173020010353 PAS fold; Region: PAS_3; pfam08447 1173020010354 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020010355 heme pocket [chemical binding]; other site 1173020010356 putative active site [active] 1173020010357 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020010358 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020010359 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020010360 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020010361 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020010362 dimer interface [polypeptide binding]; other site 1173020010363 phosphorylation site [posttranslational modification] 1173020010364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020010365 ATP binding site [chemical binding]; other site 1173020010366 Mg2+ binding site [ion binding]; other site 1173020010367 G-X-G motif; other site 1173020010368 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020010369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020010370 active site 1173020010371 phosphorylation site [posttranslational modification] 1173020010372 intermolecular recognition site; other site 1173020010373 dimerization interface [polypeptide binding]; other site 1173020010374 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020010375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020010376 active site 1173020010377 phosphorylation site [posttranslational modification] 1173020010378 intermolecular recognition site; other site 1173020010379 dimerization interface [polypeptide binding]; other site 1173020010380 CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216 1173020010381 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 1173020010382 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173020010383 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 1173020010384 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1173020010385 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173020010386 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1173020010387 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 1173020010388 trimer interface [polypeptide binding]; other site 1173020010389 active site 1173020010390 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 1173020010391 putative multimerization interface [polypeptide binding]; other site 1173020010392 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 1173020010393 putative multimerization interface [polypeptide binding]; other site 1173020010394 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cl01843 1173020010395 putative multimerization interface [polypeptide binding]; other site 1173020010396 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1173020010397 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1173020010398 Hexamer interface [polypeptide binding]; other site 1173020010399 Hexagonal pore residue; other site 1173020010400 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1173020010401 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1173020010402 Hexamer interface [polypeptide binding]; other site 1173020010403 Hexagonal pore residue; other site 1173020010404 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1173020010405 Hexamer/Pentamer interface [polypeptide binding]; other site 1173020010406 central pore; other site 1173020010407 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 1173020010408 putative multimerization interface [polypeptide binding]; other site 1173020010409 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 1173020010410 putative multimerization interface [polypeptide binding]; other site 1173020010411 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 1173020010412 putative multimerization interface [polypeptide binding]; other site 1173020010413 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1173020010414 putative trimer interface [polypeptide binding]; other site 1173020010415 putative CoA binding site [chemical binding]; other site 1173020010416 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173020010417 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173020010418 P-loop; other site 1173020010419 Magnesium ion binding site [ion binding]; other site 1173020010420 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1173020010421 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 1173020010422 Hexamer interface [polypeptide binding]; other site 1173020010423 Hexagonal pore residue; other site 1173020010424 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1173020010425 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1173020010426 Hexamer interface [polypeptide binding]; other site 1173020010427 Hexagonal pore residue; other site 1173020010428 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1173020010429 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1173020010430 Hexamer interface [polypeptide binding]; other site 1173020010431 Hexagonal pore residue; other site 1173020010432 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1173020010433 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1173020010434 Hexamer interface [polypeptide binding]; other site 1173020010435 Hexagonal pore residue; other site 1173020010436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 1173020010437 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1173020010438 FAD binding site [chemical binding]; other site 1173020010439 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1173020010440 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1173020010441 active site 1173020010442 HIGH motif; other site 1173020010443 dimer interface [polypeptide binding]; other site 1173020010444 KMSKS motif; other site 1173020010445 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173020010446 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010447 binding surface 1173020010448 TPR motif; other site 1173020010449 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010450 binding surface 1173020010451 TPR motif; other site 1173020010452 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010453 TPR motif; other site 1173020010454 binding surface 1173020010455 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010456 binding surface 1173020010457 TPR repeat; Region: TPR_11; pfam13414 1173020010458 TPR motif; other site 1173020010459 TPR repeat; Region: TPR_11; pfam13414 1173020010460 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010461 binding surface 1173020010462 TPR repeat; Region: TPR_11; pfam13414 1173020010463 TPR motif; other site 1173020010464 TPR repeat; Region: TPR_11; pfam13414 1173020010465 TPR repeat; Region: TPR_11; pfam13414 1173020010466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010467 TPR motif; other site 1173020010468 binding surface 1173020010469 TPR repeat; Region: TPR_11; pfam13414 1173020010470 TPR repeat; Region: TPR_11; pfam13414 1173020010471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010472 binding surface 1173020010473 TPR motif; other site 1173020010474 TPR repeat; Region: TPR_11; pfam13414 1173020010475 TPR repeat; Region: TPR_11; pfam13414 1173020010476 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010477 TPR motif; other site 1173020010478 binding surface 1173020010479 polynucleotide kinase; Provisional; Region: pseT; PHA02530 1173020010480 RNA ligase; Region: RNA_lig_T4_1; pfam09511 1173020010481 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1173020010482 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1173020010483 MoxR-like ATPases [General function prediction only]; Region: COG0714 1173020010484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020010485 Walker A motif; other site 1173020010486 ATP binding site [chemical binding]; other site 1173020010487 Walker B motif; other site 1173020010488 arginine finger; other site 1173020010489 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1173020010490 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1173020010491 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1173020010492 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020010493 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020010494 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020010495 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1173020010496 muropeptide transporter; Validated; Region: ampG; cl17669 1173020010497 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1173020010498 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 1173020010499 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 1173020010500 protein I interface; other site 1173020010501 D2 interface; other site 1173020010502 protein T interface; other site 1173020010503 chlorophyll binding site; other site 1173020010504 beta carotene binding site; other site 1173020010505 pheophytin binding site; other site 1173020010506 manganese-stabilizing polypeptide interface; other site 1173020010507 CP43 interface; other site 1173020010508 protein L interface; other site 1173020010509 oxygen evolving complex binding site; other site 1173020010510 bromide binding site; other site 1173020010511 quinone binding site; other site 1173020010512 Fe binding site [ion binding]; other site 1173020010513 core light harvesting interface; other site 1173020010514 cytochrome b559 alpha subunit interface; other site 1173020010515 cytochrome c-550 interface; other site 1173020010516 protein J interface; other site 1173020010517 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020010518 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020010519 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020010520 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020010521 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020010522 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020010523 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1173020010524 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1173020010525 Walker A/P-loop; other site 1173020010526 ATP binding site [chemical binding]; other site 1173020010527 Q-loop/lid; other site 1173020010528 ABC transporter signature motif; other site 1173020010529 Walker B; other site 1173020010530 D-loop; other site 1173020010531 H-loop/switch region; other site 1173020010532 TOBE domain; Region: TOBE_2; pfam08402 1173020010533 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 1173020010534 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1173020010535 dimer interface [polypeptide binding]; other site 1173020010536 phosphorylation site [posttranslational modification] 1173020010537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020010538 ATP binding site [chemical binding]; other site 1173020010539 Mg2+ binding site [ion binding]; other site 1173020010540 G-X-G motif; other site 1173020010541 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173020010542 putative binding surface; other site 1173020010543 active site 1173020010544 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173020010545 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1173020010546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020010547 ATP binding site [chemical binding]; other site 1173020010548 Mg2+ binding site [ion binding]; other site 1173020010549 G-X-G motif; other site 1173020010550 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173020010551 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020010552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020010553 active site 1173020010554 phosphorylation site [posttranslational modification] 1173020010555 intermolecular recognition site; other site 1173020010556 dimerization interface [polypeptide binding]; other site 1173020010557 Cache domain; Region: Cache_1; pfam02743 1173020010558 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173020010559 dimerization interface [polypeptide binding]; other site 1173020010560 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020010561 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020010562 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020010563 GAF domain; Region: GAF; pfam01590 1173020010564 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173020010565 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173020010566 dimer interface [polypeptide binding]; other site 1173020010567 putative CheW interface [polypeptide binding]; other site 1173020010568 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1173020010569 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020010570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020010571 active site 1173020010572 phosphorylation site [posttranslational modification] 1173020010573 intermolecular recognition site; other site 1173020010574 dimerization interface [polypeptide binding]; other site 1173020010575 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020010576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020010577 active site 1173020010578 phosphorylation site [posttranslational modification] 1173020010579 intermolecular recognition site; other site 1173020010580 dimerization interface [polypeptide binding]; other site 1173020010581 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173020010582 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173020010583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010584 binding surface 1173020010585 TPR motif; other site 1173020010586 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010587 binding surface 1173020010588 TPR motif; other site 1173020010589 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1173020010590 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1173020010591 dimer interface [polypeptide binding]; other site 1173020010592 motif 1; other site 1173020010593 active site 1173020010594 motif 2; other site 1173020010595 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1173020010596 putative deacylase active site [active] 1173020010597 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1173020010598 active site 1173020010599 motif 3; other site 1173020010600 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1173020010601 anticodon binding site; other site 1173020010602 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1173020010603 Sporulation and spore germination; Region: Germane; pfam10646 1173020010604 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1173020010605 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1173020010606 carboxyltransferase (CT) interaction site; other site 1173020010607 biotinylation site [posttranslational modification]; other site 1173020010608 elongation factor P; Validated; Region: PRK00529 1173020010609 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1173020010610 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1173020010611 RNA binding site [nucleotide binding]; other site 1173020010612 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1173020010613 RNA binding site [nucleotide binding]; other site 1173020010614 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1173020010615 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 1173020010616 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 1173020010617 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1173020010618 putative active site pocket [active] 1173020010619 4-fold oligomerization interface [polypeptide binding]; other site 1173020010620 metal binding residues [ion binding]; metal-binding site 1173020010621 3-fold/trimer interface [polypeptide binding]; other site 1173020010622 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020010623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020010624 active site 1173020010625 phosphorylation site [posttranslational modification] 1173020010626 intermolecular recognition site; other site 1173020010627 dimerization interface [polypeptide binding]; other site 1173020010628 CheW-like domain; Region: CheW; pfam01584 1173020010629 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173020010630 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173020010631 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173020010632 dimer interface [polypeptide binding]; other site 1173020010633 putative CheW interface [polypeptide binding]; other site 1173020010634 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173020010635 dimer interface [polypeptide binding]; other site 1173020010636 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1173020010637 putative CheW interface [polypeptide binding]; other site 1173020010638 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 1173020010639 four helix bundle protein; Region: TIGR02436 1173020010640 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173020010641 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173020010642 putative binding surface; other site 1173020010643 active site 1173020010644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020010645 ATP binding site [chemical binding]; other site 1173020010646 Mg2+ binding site [ion binding]; other site 1173020010647 G-X-G motif; other site 1173020010648 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173020010649 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020010650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020010651 active site 1173020010652 phosphorylation site [posttranslational modification] 1173020010653 intermolecular recognition site; other site 1173020010654 dimerization interface [polypeptide binding]; other site 1173020010655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020010656 active site 1173020010657 phosphorylation site [posttranslational modification] 1173020010658 intermolecular recognition site; other site 1173020010659 dimerization interface [polypeptide binding]; other site 1173020010660 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1173020010661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020010662 active site 1173020010663 phosphorylation site [posttranslational modification] 1173020010664 intermolecular recognition site; other site 1173020010665 dimerization interface [polypeptide binding]; other site 1173020010666 CheB methylesterase; Region: CheB_methylest; pfam01339 1173020010667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 1173020010668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020010669 S-adenosylmethionine binding site [chemical binding]; other site 1173020010670 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1173020010671 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1173020010672 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1173020010673 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020010674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020010675 active site 1173020010676 phosphorylation site [posttranslational modification] 1173020010677 intermolecular recognition site; other site 1173020010678 dimerization interface [polypeptide binding]; other site 1173020010679 PAS fold; Region: PAS_3; pfam08447 1173020010680 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020010681 dimer interface [polypeptide binding]; other site 1173020010682 phosphorylation site [posttranslational modification] 1173020010683 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020010684 ATP binding site [chemical binding]; other site 1173020010685 Mg2+ binding site [ion binding]; other site 1173020010686 G-X-G motif; other site 1173020010687 CheB methylesterase; Region: CheB_methylest; pfam01339 1173020010688 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1173020010689 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1173020010690 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1173020010691 PAS domain; Region: PAS_10; pfam13596 1173020010692 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020010693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020010694 dimer interface [polypeptide binding]; other site 1173020010695 phosphorylation site [posttranslational modification] 1173020010696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020010697 ATP binding site [chemical binding]; other site 1173020010698 Mg2+ binding site [ion binding]; other site 1173020010699 G-X-G motif; other site 1173020010700 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020010701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020010702 active site 1173020010703 phosphorylation site [posttranslational modification] 1173020010704 intermolecular recognition site; other site 1173020010705 dimerization interface [polypeptide binding]; other site 1173020010706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020010707 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020010708 active site 1173020010709 phosphorylation site [posttranslational modification] 1173020010710 intermolecular recognition site; other site 1173020010711 dimerization interface [polypeptide binding]; other site 1173020010712 PAS fold; Region: PAS_4; pfam08448 1173020010713 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020010714 putative active site [active] 1173020010715 heme pocket [chemical binding]; other site 1173020010716 PAS domain S-box; Region: sensory_box; TIGR00229 1173020010717 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020010718 putative active site [active] 1173020010719 heme pocket [chemical binding]; other site 1173020010720 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020010721 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173020010722 putative active site [active] 1173020010723 heme pocket [chemical binding]; other site 1173020010724 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020010725 putative active site [active] 1173020010726 heme pocket [chemical binding]; other site 1173020010727 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1173020010728 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020010729 dimer interface [polypeptide binding]; other site 1173020010730 phosphorylation site [posttranslational modification] 1173020010731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020010732 ATP binding site [chemical binding]; other site 1173020010733 Mg2+ binding site [ion binding]; other site 1173020010734 G-X-G motif; other site 1173020010735 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1173020010736 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 1173020010737 active site 1173020010738 Thf1-like protein; Reviewed; Region: PRK13266 1173020010739 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 1173020010740 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010741 TPR repeat; Region: TPR_11; pfam13414 1173020010742 binding surface 1173020010743 TPR motif; other site 1173020010744 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010745 binding surface 1173020010746 TPR repeat; Region: TPR_11; pfam13414 1173020010747 TPR motif; other site 1173020010748 TPR repeat; Region: TPR_11; pfam13414 1173020010749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173020010750 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1173020010751 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1173020010752 putative dimer interface [polypeptide binding]; other site 1173020010753 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 1173020010754 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1173020010755 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1173020010756 active site 1173020010757 homodimer interface [polypeptide binding]; other site 1173020010758 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1173020010759 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 1173020010760 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1173020010761 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1173020010762 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173020010763 NMT1-like family; Region: NMT1_2; pfam13379 1173020010764 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1173020010765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020010766 ABC-ATPase subunit interface; other site 1173020010767 putative PBP binding loops; other site 1173020010768 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173020010769 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1173020010770 Walker A/P-loop; other site 1173020010771 ATP binding site [chemical binding]; other site 1173020010772 Q-loop/lid; other site 1173020010773 ABC transporter signature motif; other site 1173020010774 Walker B; other site 1173020010775 D-loop; other site 1173020010776 H-loop/switch region; other site 1173020010777 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173020010778 NMT1-like family; Region: NMT1_2; pfam13379 1173020010779 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173020010780 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1173020010781 Walker A/P-loop; other site 1173020010782 ATP binding site [chemical binding]; other site 1173020010783 Q-loop/lid; other site 1173020010784 ABC transporter signature motif; other site 1173020010785 Walker B; other site 1173020010786 D-loop; other site 1173020010787 H-loop/switch region; other site 1173020010788 Predicted membrane protein [Function unknown]; Region: COG3650 1173020010789 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1173020010790 Right handed beta helix region; Region: Beta_helix; pfam13229 1173020010791 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020010792 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1173020010793 putative ADP-binding pocket [chemical binding]; other site 1173020010794 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 1173020010795 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020010796 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173020010797 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1173020010798 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1173020010799 KGK domain; Region: KGK; pfam08872 1173020010800 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 1173020010801 homodimer interface [polypeptide binding]; other site 1173020010802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020010803 catalytic residue [active] 1173020010804 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010805 TPR repeat; Region: TPR_11; pfam13414 1173020010806 binding surface 1173020010807 TPR motif; other site 1173020010808 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010809 binding surface 1173020010810 TPR repeat; Region: TPR_11; pfam13414 1173020010811 TPR motif; other site 1173020010812 TPR repeat; Region: TPR_11; pfam13414 1173020010813 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010814 binding surface 1173020010815 TPR repeat; Region: TPR_11; pfam13414 1173020010816 TPR motif; other site 1173020010817 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1173020010818 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010819 binding surface 1173020010820 TPR motif; other site 1173020010821 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010822 binding surface 1173020010823 TPR motif; other site 1173020010824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010825 binding surface 1173020010826 TPR motif; other site 1173020010827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010828 binding surface 1173020010829 TPR motif; other site 1173020010830 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010831 binding surface 1173020010832 TPR motif; other site 1173020010833 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010834 binding surface 1173020010835 TPR motif; other site 1173020010836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010837 binding surface 1173020010838 TPR motif; other site 1173020010839 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010840 binding surface 1173020010841 TPR motif; other site 1173020010842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010843 binding surface 1173020010844 TPR motif; other site 1173020010845 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010846 binding surface 1173020010847 TPR motif; other site 1173020010848 TPR repeat; Region: TPR_11; pfam13414 1173020010849 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010850 binding surface 1173020010851 TPR motif; other site 1173020010852 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173020010853 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010854 binding surface 1173020010855 TPR motif; other site 1173020010856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010857 binding surface 1173020010858 TPR motif; other site 1173020010859 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010860 binding surface 1173020010861 TPR motif; other site 1173020010862 TPR repeat; Region: TPR_11; pfam13414 1173020010863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010864 binding surface 1173020010865 TPR motif; other site 1173020010866 TPR repeat; Region: TPR_11; pfam13414 1173020010867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020010868 binding surface 1173020010869 TPR motif; other site 1173020010870 TPR repeat; Region: TPR_11; pfam13414 1173020010871 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 1173020010872 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1173020010873 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 1173020010874 putative active site [active] 1173020010875 catalytic site [active] 1173020010876 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1173020010877 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020010878 Walker A/P-loop; other site 1173020010879 ATP binding site [chemical binding]; other site 1173020010880 Q-loop/lid; other site 1173020010881 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1173020010882 ABC transporter signature motif; other site 1173020010883 Walker B; other site 1173020010884 D-loop; other site 1173020010885 ABC transporter; Region: ABC_tran_2; pfam12848 1173020010886 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1173020010887 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1173020010888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020010889 S-adenosylmethionine binding site [chemical binding]; other site 1173020010890 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020010891 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020010892 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020010893 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020010894 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1173020010895 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173020010896 Predicted membrane protein [Function unknown]; Region: COG2119 1173020010897 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1173020010898 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1173020010899 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020010900 putative active site [active] 1173020010901 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1173020010902 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1173020010903 G1 box; other site 1173020010904 putative GEF interaction site [polypeptide binding]; other site 1173020010905 GTP/Mg2+ binding site [chemical binding]; other site 1173020010906 Switch I region; other site 1173020010907 G2 box; other site 1173020010908 G3 box; other site 1173020010909 Switch II region; other site 1173020010910 G4 box; other site 1173020010911 G5 box; other site 1173020010912 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1173020010913 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1173020010914 Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378 1173020010915 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173020010916 active site 1173020010917 metal binding site [ion binding]; metal-binding site 1173020010918 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173020010919 HSP70 interaction site [polypeptide binding]; other site 1173020010920 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1173020010921 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1173020010922 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1173020010923 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1173020010924 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1173020010925 Domain of unknown function DUF21; Region: DUF21; pfam01595 1173020010926 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1173020010927 Transporter associated domain; Region: CorC_HlyC; smart01091 1173020010928 Protein of unknown function, DUF399; Region: DUF399; pfam04187 1173020010929 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1173020010930 active site 1173020010931 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173020010932 TIGR04168 family protein; Region: TIGR04168 1173020010933 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 1173020010934 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1173020010935 G1 box; other site 1173020010936 GTP/Mg2+ binding site [chemical binding]; other site 1173020010937 G3 box; other site 1173020010938 Switch II region; other site 1173020010939 G4 box; other site 1173020010940 G5 box; other site 1173020010941 Domain of unknown function (DUF697); Region: DUF697; pfam05128 1173020010942 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1173020010943 homooctamer interface [polypeptide binding]; other site 1173020010944 active site 1173020010945 KGK domain; Region: KGK; pfam08872 1173020010946 cytochrome c biogenesis protein; Region: ccsA; CHL00045 1173020010947 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1173020010948 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1173020010949 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1173020010950 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1173020010951 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1173020010952 dimer interface [polypeptide binding]; other site 1173020010953 active site 1173020010954 catalytic residue [active] 1173020010955 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1173020010956 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1173020010957 trigger factor; Provisional; Region: tig; PRK01490 1173020010958 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1173020010959 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1173020010960 Clp protease; Region: CLP_protease; pfam00574 1173020010961 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1173020010962 oligomer interface [polypeptide binding]; other site 1173020010963 active site residues [active] 1173020010964 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1173020010965 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1173020010966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020010967 Walker A motif; other site 1173020010968 ATP binding site [chemical binding]; other site 1173020010969 Walker B motif; other site 1173020010970 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1173020010971 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1173020010972 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 1173020010973 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 1173020010974 trimer interface [polypeptide binding]; other site 1173020010975 active site 1173020010976 photochlorophyllide reductase subunit L; Region: chlL; CHL00072 1173020010977 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 1173020010978 P-loop; other site 1173020010979 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 1173020010980 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 1173020010981 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173020010982 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173020010983 TPR motif; other site 1173020010984 binding surface 1173020010985 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1173020010986 Glycoprotease family; Region: Peptidase_M22; pfam00814 1173020010987 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1173020010988 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1173020010989 active site 1173020010990 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1173020010991 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1173020010992 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1173020010993 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1173020010994 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1173020010995 Homeodomain-like domain; Region: HTH_23; pfam13384 1173020010996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1173020010997 DDE superfamily endonuclease; Region: DDE_5; cl17874 1173020010998 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1173020010999 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1173020011000 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1173020011001 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1173020011002 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1173020011003 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173020011004 catalytic residue [active] 1173020011005 photosystem II reaction center protein Psb28; Provisional; Region: PRK13612 1173020011006 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1173020011007 MPT binding site; other site 1173020011008 trimer interface [polypeptide binding]; other site 1173020011009 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1173020011010 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 1173020011011 active site 1173020011012 substrate binding site [chemical binding]; other site 1173020011013 metal binding site [ion binding]; metal-binding site 1173020011014 hypothetical protein; Reviewed; Region: PRK00024 1173020011015 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1173020011016 MPN+ (JAMM) motif; other site 1173020011017 Zinc-binding site [ion binding]; other site 1173020011018 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1173020011019 putative rRNA binding site [nucleotide binding]; other site 1173020011020 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1173020011021 arginine-tRNA ligase; Region: PLN02286 1173020011022 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1173020011023 active site 1173020011024 HIGH motif; other site 1173020011025 KMSK motif region; other site 1173020011026 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1173020011027 tRNA binding surface [nucleotide binding]; other site 1173020011028 anticodon binding site; other site 1173020011029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020011030 H+ Antiporter protein; Region: 2A0121; TIGR00900 1173020011031 putative substrate translocation pore; other site 1173020011032 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 1173020011033 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1173020011034 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1173020011035 putative di-iron ligands [ion binding]; other site 1173020011036 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1173020011037 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1173020011038 catalytic nucleophile [active] 1173020011039 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1173020011040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020011041 Coenzyme A binding pocket [chemical binding]; other site 1173020011042 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1173020011043 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1173020011044 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 1173020011045 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 1173020011046 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1173020011047 Amidinotransferase; Region: Amidinotransf; pfam02274 1173020011048 Uncharacterized conserved protein [Function unknown]; Region: COG1915 1173020011049 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 1173020011050 homodimer interface [polypeptide binding]; other site 1173020011051 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1173020011052 proposed catalytic triad [active] 1173020011053 active site nucleophile [active] 1173020011054 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 1173020011055 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173020011056 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173020011057 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1173020011058 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173020011059 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1173020011060 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1173020011061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020011062 dimer interface [polypeptide binding]; other site 1173020011063 conserved gate region; other site 1173020011064 putative PBP binding loops; other site 1173020011065 ABC-ATPase subunit interface; other site 1173020011066 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1173020011067 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1173020011068 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173020011069 Walker A/P-loop; other site 1173020011070 ATP binding site [chemical binding]; other site 1173020011071 Q-loop/lid; other site 1173020011072 ABC transporter signature motif; other site 1173020011073 Walker B; other site 1173020011074 D-loop; other site 1173020011075 H-loop/switch region; other site 1173020011076 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1173020011077 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1173020011078 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1173020011079 urea carboxylase; Region: urea_carbox; TIGR02712 1173020011080 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173020011081 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1173020011082 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1173020011083 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1173020011084 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1173020011085 carboxyltransferase (CT) interaction site; other site 1173020011086 biotinylation site [posttranslational modification]; other site 1173020011087 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1173020011088 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1173020011089 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1173020011090 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 1173020011091 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1173020011092 ykkC-yxkD leader; IMG reference gene:2510440538; Cha6605_4539 1173020011093 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 1173020011094 carotene isomerase; Region: carot_isom; TIGR02730 1173020011095 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173020011096 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1173020011097 TPR repeat; Region: TPR_11; pfam13414 1173020011098 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020011099 binding surface 1173020011100 TPR motif; other site 1173020011101 TPR repeat; Region: TPR_11; pfam13414 1173020011102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020011103 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1173020011104 Walker A motif; other site 1173020011105 ATP binding site [chemical binding]; other site 1173020011106 Walker B motif; other site 1173020011107 arginine finger; other site 1173020011108 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1173020011109 Double zinc ribbon; Region: DZR; pfam12773 1173020011110 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1173020011111 Protein phosphatase 2C; Region: PP2C; pfam00481 1173020011112 active site 1173020011113 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1173020011114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020011115 TPR motif; other site 1173020011116 binding surface 1173020011117 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 1173020011118 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173020011119 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1173020011120 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173020011121 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173020011122 catalytic residue [active] 1173020011123 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1173020011124 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020011125 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1173020011126 active site 1173020011127 catalytic residues [active] 1173020011128 DNA binding site [nucleotide binding] 1173020011129 Int/Topo IB signature motif; other site 1173020011130 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 1173020011131 Virulence-associated protein E; Region: VirE; pfam05272 1173020011132 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1173020011133 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173020011134 ATP binding site [chemical binding]; other site 1173020011135 putative Mg++ binding site [ion binding]; other site 1173020011136 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173020011137 nucleotide binding region [chemical binding]; other site 1173020011138 ATP-binding site [chemical binding]; other site 1173020011139 Terminase small subunit; Region: Terminase_2; pfam03592 1173020011140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020011141 binding surface 1173020011142 TPR repeat; Region: TPR_11; pfam13414 1173020011143 TPR motif; other site 1173020011144 TPR repeat; Region: TPR_11; pfam13414 1173020011145 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1173020011146 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1173020011147 NAD(P) binding site [chemical binding]; other site 1173020011148 homotetramer interface [polypeptide binding]; other site 1173020011149 homodimer interface [polypeptide binding]; other site 1173020011150 active site 1173020011151 recombination protein F; Reviewed; Region: recF; PRK00064 1173020011152 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1173020011153 Walker A/P-loop; other site 1173020011154 ATP binding site [chemical binding]; other site 1173020011155 Q-loop/lid; other site 1173020011156 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020011157 ABC transporter signature motif; other site 1173020011158 Walker B; other site 1173020011159 D-loop; other site 1173020011160 H-loop/switch region; other site 1173020011161 mechanosensitive channel MscS; Provisional; Region: PRK10334 1173020011162 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173020011163 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1173020011164 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 1173020011165 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 1173020011166 RNA polymerase sigma factor; Provisional; Region: PRK12518 1173020011167 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173020011168 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173020011169 DNA binding residues [nucleotide binding] 1173020011170 cyanate hydratase; Validated; Region: PRK02866 1173020011171 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1173020011172 oligomer interface [polypeptide binding]; other site 1173020011173 active site 1173020011174 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1173020011175 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1173020011176 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1173020011177 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1173020011178 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173020011179 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020011180 active site 1173020011181 ATP binding site [chemical binding]; other site 1173020011182 substrate binding site [chemical binding]; other site 1173020011183 activation loop (A-loop); other site 1173020011184 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173020011185 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020011186 active site 1173020011187 ATP binding site [chemical binding]; other site 1173020011188 substrate binding site [chemical binding]; other site 1173020011189 activation loop (A-loop); other site 1173020011190 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1173020011191 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1173020011192 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1173020011193 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1173020011194 active site 1173020011195 metal binding site [ion binding]; metal-binding site 1173020011196 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1173020011197 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1173020011198 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cl02442 1173020011199 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1173020011200 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020011201 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020011202 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020011203 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1173020011204 Peptidase family M23; Region: Peptidase_M23; pfam01551 1173020011205 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 1173020011206 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1173020011207 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 1173020011208 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020011209 Walker A/P-loop; other site 1173020011210 ATP binding site [chemical binding]; other site 1173020011211 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1173020011212 Peptidase family U32; Region: Peptidase_U32; pfam01136 1173020011213 Collagenase; Region: DUF3656; pfam12392 1173020011214 Peptidase family U32; Region: Peptidase_U32; cl03113 1173020011215 Predicted permeases [General function prediction only]; Region: COG0795 1173020011216 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1173020011217 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1173020011218 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1173020011219 Walker A/P-loop; other site 1173020011220 ATP binding site [chemical binding]; other site 1173020011221 Q-loop/lid; other site 1173020011222 ABC transporter signature motif; other site 1173020011223 Walker B; other site 1173020011224 D-loop; other site 1173020011225 H-loop/switch region; other site 1173020011226 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1173020011227 OstA-like protein; Region: OstA; pfam03968 1173020011228 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1173020011229 OstA-like protein; Region: OstA; cl00844 1173020011230 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1173020011231 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020011232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020011233 active site 1173020011234 phosphorylation site [posttranslational modification] 1173020011235 intermolecular recognition site; other site 1173020011236 dimerization interface [polypeptide binding]; other site 1173020011237 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173020011238 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173020011239 dimerization interface [polypeptide binding]; other site 1173020011240 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173020011241 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173020011242 dimer interface [polypeptide binding]; other site 1173020011243 putative CheW interface [polypeptide binding]; other site 1173020011244 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173020011245 putative binding surface; other site 1173020011246 active site 1173020011247 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173020011248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020011249 ATP binding site [chemical binding]; other site 1173020011250 Mg2+ binding site [ion binding]; other site 1173020011251 G-X-G motif; other site 1173020011252 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173020011253 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020011254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020011255 active site 1173020011256 phosphorylation site [posttranslational modification] 1173020011257 intermolecular recognition site; other site 1173020011258 dimerization interface [polypeptide binding]; other site 1173020011259 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 1173020011260 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 1173020011261 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1173020011262 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1173020011263 homodimer interface [polypeptide binding]; other site 1173020011264 Walker A motif; other site 1173020011265 ATP binding site [chemical binding]; other site 1173020011266 hydroxycobalamin binding site [chemical binding]; other site 1173020011267 Walker B motif; other site 1173020011268 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1173020011269 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1173020011270 putative tRNA-binding site [nucleotide binding]; other site 1173020011271 B3/4 domain; Region: B3_4; pfam03483 1173020011272 tRNA synthetase B5 domain; Region: B5; smart00874 1173020011273 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1173020011274 dimer interface [polypeptide binding]; other site 1173020011275 motif 1; other site 1173020011276 motif 3; other site 1173020011277 motif 2; other site 1173020011278 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1173020011279 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1173020011280 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020011281 active site 1173020011282 ATP binding site [chemical binding]; other site 1173020011283 substrate binding site [chemical binding]; other site 1173020011284 activation loop (A-loop); other site 1173020011285 Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605 1173020011286 photosystem I reaction center subunit IX; Provisional; Region: PRK02733 1173020011287 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 1173020011288 UGMP family protein; Validated; Region: PRK09604 1173020011289 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1173020011290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020011291 S-adenosylmethionine binding site [chemical binding]; other site 1173020011292 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1173020011293 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1173020011294 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1173020011295 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1173020011296 Competence protein; Region: Competence; pfam03772 1173020011297 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1173020011298 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1173020011299 DNA-binding interface [nucleotide binding]; DNA binding site 1173020011300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1173020011301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173020011302 TPR motif; other site 1173020011303 binding surface 1173020011304 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1173020011305 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1173020011306 Walker A/P-loop; other site 1173020011307 ATP binding site [chemical binding]; other site 1173020011308 Q-loop/lid; other site 1173020011309 ABC transporter signature motif; other site 1173020011310 Walker B; other site 1173020011311 D-loop; other site 1173020011312 H-loop/switch region; other site 1173020011313 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1173020011314 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1173020011315 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1173020011316 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1173020011317 Type II transport protein GspH; Region: GspH; pfam12019 1173020011318 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1173020011319 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1173020011320 MPN+ (JAMM) motif; other site 1173020011321 Zinc-binding site [ion binding]; other site 1173020011322 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1173020011323 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1173020011324 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1173020011325 Mg++ binding site [ion binding]; other site 1173020011326 putative catalytic motif [active] 1173020011327 substrate binding site [chemical binding]; other site 1173020011328 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1173020011329 metal binding site 2 [ion binding]; metal-binding site 1173020011330 putative DNA binding helix; other site 1173020011331 metal binding site 1 [ion binding]; metal-binding site 1173020011332 dimer interface [polypeptide binding]; other site 1173020011333 structural Zn2+ binding site [ion binding]; other site 1173020011334 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1173020011335 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1173020011336 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1173020011337 putative active site [active] 1173020011338 catalytic triad [active] 1173020011339 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1173020011340 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 1173020011341 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1173020011342 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1173020011343 purine monophosphate binding site [chemical binding]; other site 1173020011344 dimer interface [polypeptide binding]; other site 1173020011345 putative catalytic residues [active] 1173020011346 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1173020011347 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1173020011348 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 1173020011349 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1173020011350 RNA polymerase sigma factor RpoD; Validated; Region: PRK07406 1173020011351 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1173020011352 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173020011353 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173020011354 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173020011355 DNA binding residues [nucleotide binding] 1173020011356 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020011357 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1173020011358 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1173020011359 Cl- selectivity filter; other site 1173020011360 Cl- binding residues [ion binding]; other site 1173020011361 pore gating glutamate residue; other site 1173020011362 dimer interface [polypeptide binding]; other site 1173020011363 H+/Cl- coupling transport residue; other site 1173020011364 FOG: CBS domain [General function prediction only]; Region: COG0517 1173020011365 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 1173020011366 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 1173020011367 Ligand Binding Site [chemical binding]; other site 1173020011368 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1173020011369 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1173020011370 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173020011371 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173020011372 PsbP; Region: PsbP; pfam01789 1173020011373 Maf-like protein; Region: Maf; pfam02545 1173020011374 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1173020011375 active site 1173020011376 dimer interface [polypeptide binding]; other site 1173020011377 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1173020011378 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1173020011379 active site residue [active] 1173020011380 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1173020011381 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1173020011382 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1173020011383 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1173020011384 putative active site [active] 1173020011385 oxyanion strand; other site 1173020011386 catalytic triad [active] 1173020011387 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020011388 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1173020011389 putative acyl transferase; Provisional; Region: PRK10502 1173020011390 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1173020011391 putative trimer interface [polypeptide binding]; other site 1173020011392 putative active site [active] 1173020011393 putative substrate binding site [chemical binding]; other site 1173020011394 putative CoA binding site [chemical binding]; other site 1173020011395 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173020011396 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1173020011397 putative metal binding site; other site 1173020011398 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1173020011399 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173020011400 catalytic loop [active] 1173020011401 iron binding site [ion binding]; other site 1173020011402 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1173020011403 L-aspartate oxidase; Provisional; Region: PRK06175 1173020011404 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1173020011405 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1173020011406 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1173020011407 putative Iron-sulfur protein interface [polypeptide binding]; other site 1173020011408 proximal heme binding site [chemical binding]; other site 1173020011409 distal heme binding site [chemical binding]; other site 1173020011410 putative dimer interface [polypeptide binding]; other site 1173020011411 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020011412 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 1173020011413 putative ADP-binding pocket [chemical binding]; other site 1173020011414 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1173020011415 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173020011416 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020011417 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 1173020011418 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1173020011419 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020011420 Exostosin family; Region: Exostosin; pfam03016 1173020011421 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173020011422 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020011423 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1173020011424 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020011425 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173020011426 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1173020011427 metal-binding site 1173020011428 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 1173020011429 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1173020011430 putative trimer interface [polypeptide binding]; other site 1173020011431 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 1173020011432 putative CoA binding site [chemical binding]; other site 1173020011433 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1173020011434 trimer interface [polypeptide binding]; other site 1173020011435 active site 1173020011436 substrate binding site [chemical binding]; other site 1173020011437 CoA binding site [chemical binding]; other site 1173020011438 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1173020011439 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173020011440 active site 1173020011441 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1173020011442 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020011443 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1173020011444 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1173020011445 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020011446 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173020011447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020011448 S-adenosylmethionine binding site [chemical binding]; other site 1173020011449 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1173020011450 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1173020011451 Walker A/P-loop; other site 1173020011452 ATP binding site [chemical binding]; other site 1173020011453 Q-loop/lid; other site 1173020011454 ABC transporter signature motif; other site 1173020011455 Walker B; other site 1173020011456 D-loop; other site 1173020011457 H-loop/switch region; other site 1173020011458 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1173020011459 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 1173020011460 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1173020011461 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1173020011462 NADP-binding site; other site 1173020011463 homotetramer interface [polypeptide binding]; other site 1173020011464 substrate binding site [chemical binding]; other site 1173020011465 homodimer interface [polypeptide binding]; other site 1173020011466 active site 1173020011467 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1173020011468 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1173020011469 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1173020011470 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1173020011471 NAD binding site [chemical binding]; other site 1173020011472 homodimer interface [polypeptide binding]; other site 1173020011473 active site 1173020011474 substrate binding site [chemical binding]; other site 1173020011475 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173020011476 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020011477 binding surface 1173020011478 TPR motif; other site 1173020011479 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173020011480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020011481 binding surface 1173020011482 TPR motif; other site 1173020011483 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173020011484 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173020011485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020011486 binding surface 1173020011487 TPR motif; other site 1173020011488 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173020011489 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173020011490 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1173020011491 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173020011492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020011493 binding surface 1173020011494 TPR motif; other site 1173020011495 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173020011496 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173020011497 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020011498 binding surface 1173020011499 TPR motif; other site 1173020011500 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1173020011501 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1173020011502 ribosomal protein L23; Region: rpl23; CHL00030 1173020011503 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1173020011504 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1173020011505 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1173020011506 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1173020011507 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1173020011508 putative translocon binding site; other site 1173020011509 protein-rRNA interface [nucleotide binding]; other site 1173020011510 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1173020011511 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1173020011512 G-X-X-G motif; other site 1173020011513 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1173020011514 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1173020011515 23S rRNA interface [nucleotide binding]; other site 1173020011516 5S rRNA interface [nucleotide binding]; other site 1173020011517 putative antibiotic binding site [chemical binding]; other site 1173020011518 L25 interface [polypeptide binding]; other site 1173020011519 L27 interface [polypeptide binding]; other site 1173020011520 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1173020011521 putative translocon interaction site; other site 1173020011522 signal recognition particle (SRP54) interaction site; other site 1173020011523 L23 interface [polypeptide binding]; other site 1173020011524 trigger factor interaction site; other site 1173020011525 23S rRNA interface [nucleotide binding]; other site 1173020011526 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1173020011527 ribosomal protein L14; Region: rpl14; CHL00057 1173020011528 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1173020011529 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1173020011530 RNA binding site [nucleotide binding]; other site 1173020011531 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1173020011532 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1173020011533 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1173020011534 ribosomal protein S8; Region: rps8; CHL00042 1173020011535 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1173020011536 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1173020011537 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1173020011538 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1173020011539 23S rRNA interface [nucleotide binding]; other site 1173020011540 L21e interface [polypeptide binding]; other site 1173020011541 5S rRNA interface [nucleotide binding]; other site 1173020011542 L27 interface [polypeptide binding]; other site 1173020011543 L5 interface [polypeptide binding]; other site 1173020011544 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1173020011545 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1173020011546 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1173020011547 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1173020011548 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1173020011549 SecY translocase; Region: SecY; pfam00344 1173020011550 adenylate kinase; Provisional; Region: adk; PRK02496 1173020011551 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1173020011552 AMP-binding site [chemical binding]; other site 1173020011553 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1173020011554 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1173020011555 rRNA binding site [nucleotide binding]; other site 1173020011556 predicted 30S ribosome binding site; other site 1173020011557 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1173020011558 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1173020011559 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1173020011560 30S ribosomal protein S11; Validated; Region: PRK05309 1173020011561 RNA polymerase alpha subunit; Region: rpoA; CHL00013 1173020011562 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1173020011563 alphaNTD homodimer interface [polypeptide binding]; other site 1173020011564 alphaNTD - beta interaction site [polypeptide binding]; other site 1173020011565 alphaNTD - beta' interaction site [polypeptide binding]; other site 1173020011566 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1173020011567 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1173020011568 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1173020011569 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1173020011570 dimerization interface 3.5A [polypeptide binding]; other site 1173020011571 active site 1173020011572 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1173020011573 23S rRNA interface [nucleotide binding]; other site 1173020011574 L3 interface [polypeptide binding]; other site 1173020011575 ribosomal protein S9; Region: rps9; CHL00079 1173020011576 ribosomal protein L31; Validated; Region: rpl31; CHL00136 1173020011577 Leucine rich repeat; Region: LRR_8; pfam13855 1173020011578 Leucine rich repeat; Region: LRR_8; pfam13855 1173020011579 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1173020011580 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1173020011581 RF-1 domain; Region: RF-1; pfam00472 1173020011582 PCRF domain; Region: PCRF; cl17745 1173020011583 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 1173020011584 ADP-ribose binding site [chemical binding]; other site 1173020011585 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1173020011586 SmpB-tmRNA interface; other site 1173020011587 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1173020011588 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1173020011589 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173020011590 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1173020011591 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1173020011592 FAD binding domain; Region: FAD_binding_4; pfam01565 1173020011593 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1173020011594 hypothetical protein; Validated; Region: PRK00153 1173020011595 Ion channel; Region: Ion_trans_2; pfam07885 1173020011596 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173020011597 TrkA-N domain; Region: TrkA_N; pfam02254 1173020011598 TrkA-C domain; Region: TrkA_C; pfam02080 1173020011599 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1173020011600 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1173020011601 DNA protecting protein DprA; Region: dprA; TIGR00732 1173020011602 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 1173020011603 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173020011604 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1173020011605 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020011606 active site 1173020011607 motif I; other site 1173020011608 motif II; other site 1173020011609 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1173020011610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020011611 dimer interface [polypeptide binding]; other site 1173020011612 conserved gate region; other site 1173020011613 putative PBP binding loops; other site 1173020011614 ABC-ATPase subunit interface; other site 1173020011615 tellurium resistance terB-like protein; Region: terB_like; cd07177 1173020011616 metal binding site [ion binding]; metal-binding site 1173020011617 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1173020011618 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1173020011619 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020011620 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020011621 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020011622 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1173020011623 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1173020011624 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1173020011625 NADP-binding site; other site 1173020011626 homotetramer interface [polypeptide binding]; other site 1173020011627 substrate binding site [chemical binding]; other site 1173020011628 homodimer interface [polypeptide binding]; other site 1173020011629 active site 1173020011630 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1173020011631 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1173020011632 NADP binding site [chemical binding]; other site 1173020011633 active site 1173020011634 putative substrate binding site [chemical binding]; other site 1173020011635 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173020011636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020011637 S-adenosylmethionine binding site [chemical binding]; other site 1173020011638 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1173020011639 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1173020011640 putative di-iron ligands [ion binding]; other site 1173020011641 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1173020011642 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1173020011643 active site lid residues [active] 1173020011644 substrate binding pocket [chemical binding]; other site 1173020011645 catalytic residues [active] 1173020011646 substrate-Mg2+ binding site; other site 1173020011647 aspartate-rich region 1; other site 1173020011648 aspartate-rich region 2; other site 1173020011649 phytoene desaturase; Region: phytoene_desat; TIGR02731 1173020011650 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173020011651 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020011652 TPR motif; other site 1173020011653 binding surface 1173020011654 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020011655 TPR motif; other site 1173020011656 binding surface 1173020011657 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1173020011658 substrate binding site [polypeptide binding]; other site 1173020011659 dimer interface [polypeptide binding]; other site 1173020011660 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1173020011661 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020011662 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1173020011663 substrate binding site [polypeptide binding]; other site 1173020011664 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020011665 binding surface 1173020011666 TPR motif; other site 1173020011667 TPR repeat; Region: TPR_11; pfam13414 1173020011668 TPR repeat; Region: TPR_11; pfam13414 1173020011669 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1173020011670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020011671 ATP binding site [chemical binding]; other site 1173020011672 Walker B motif; other site 1173020011673 arginine finger; other site 1173020011674 Transposase domain (DUF772); Region: DUF772; pfam05598 1173020011675 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020011676 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1173020011677 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173020011678 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173020011679 Probable transposase; Region: OrfB_IS605; pfam01385 1173020011680 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173020011681 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173020011682 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173020011683 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1173020011684 Walker A/P-loop; other site 1173020011685 ATP binding site [chemical binding]; other site 1173020011686 Q-loop/lid; other site 1173020011687 ABC transporter signature motif; other site 1173020011688 Walker B; other site 1173020011689 D-loop; other site 1173020011690 H-loop/switch region; other site 1173020011691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 1173020011692 conserved hypothetical protein; Region: TIGR03492 1173020011693 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173020011694 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173020011695 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1173020011696 C-terminal domain interface [polypeptide binding]; other site 1173020011697 GSH binding site (G-site) [chemical binding]; other site 1173020011698 dimer interface [polypeptide binding]; other site 1173020011699 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1173020011700 N-terminal domain interface [polypeptide binding]; other site 1173020011701 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173020011702 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1173020011703 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1173020011704 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173020011705 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173020011706 active site 1173020011707 PBP superfamily domain; Region: PBP_like_2; pfam12849 1173020011708 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 1173020011709 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 1173020011710 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl17581 1173020011711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 1173020011712 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1173020011713 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1173020011714 active site 1173020011715 homodimer interface [polypeptide binding]; other site 1173020011716 catalytic site [active] 1173020011717 Predicted GTPase [General function prediction only]; Region: COG3596 1173020011718 YfjP GTPase; Region: YfjP; cd11383 1173020011719 G1 box; other site 1173020011720 GTP/Mg2+ binding site [chemical binding]; other site 1173020011721 Switch I region; other site 1173020011722 G2 box; other site 1173020011723 Switch II region; other site 1173020011724 G3 box; other site 1173020011725 G4 box; other site 1173020011726 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020011727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020011728 active site 1173020011729 phosphorylation site [posttranslational modification] 1173020011730 intermolecular recognition site; other site 1173020011731 dimerization interface [polypeptide binding]; other site 1173020011732 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020011733 DNA binding site [nucleotide binding] 1173020011734 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173020011735 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173020011736 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1173020011737 HAMP domain; Region: HAMP; pfam00672 1173020011738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020011739 dimer interface [polypeptide binding]; other site 1173020011740 phosphorylation site [posttranslational modification] 1173020011741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020011742 ATP binding site [chemical binding]; other site 1173020011743 Mg2+ binding site [ion binding]; other site 1173020011744 G-X-G motif; other site 1173020011745 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1173020011746 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173020011747 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1173020011748 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1173020011749 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1173020011750 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173020011751 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173020011752 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173020011753 catalytic residues [active] 1173020011754 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1173020011755 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 1173020011756 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 1173020011757 four helix bundle protein; Region: TIGR02436 1173020011758 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1173020011759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020011760 dimer interface [polypeptide binding]; other site 1173020011761 conserved gate region; other site 1173020011762 putative PBP binding loops; other site 1173020011763 ABC-ATPase subunit interface; other site 1173020011764 Isochorismatase family; Region: Isochorismatase; pfam00857 1173020011765 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1173020011766 catalytic triad [active] 1173020011767 conserved cis-peptide bond; other site 1173020011768 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1173020011769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1173020011770 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1173020011771 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1173020011772 active site 1173020011773 dimer interface [polypeptide binding]; other site 1173020011774 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1173020011775 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1173020011776 active site 1173020011777 FMN binding site [chemical binding]; other site 1173020011778 substrate binding site [chemical binding]; other site 1173020011779 3Fe-4S cluster binding site [ion binding]; other site 1173020011780 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1173020011781 domain interface; other site 1173020011782 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1173020011783 Protein of unknown function DUF262; Region: DUF262; pfam03235 1173020011784 PIN domain; Region: PIN; pfam01850 1173020011785 putative active site [active] 1173020011786 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1173020011787 Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480 1173020011788 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1173020011789 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1173020011790 hydrophobic ligand binding site; other site 1173020011791 Pheophorbide a oxygenase; Region: PaO; pfam08417 1173020011792 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173020011793 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020011794 active site 1173020011795 ATP binding site [chemical binding]; other site 1173020011796 substrate binding site [chemical binding]; other site 1173020011797 activation loop (A-loop); other site 1173020011798 ribosomal protein L32; Validated; Region: rpl32; CHL00152 1173020011799 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1173020011800 30S subunit binding site; other site 1173020011801 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173020011802 active site 1173020011803 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 1173020011804 Tic20-like protein; Region: Tic20; pfam09685 1173020011805 Permease; Region: Permease; cl00510 1173020011806 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1173020011807 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1173020011808 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1173020011809 G1 box; other site 1173020011810 putative GEF interaction site [polypeptide binding]; other site 1173020011811 GTP/Mg2+ binding site [chemical binding]; other site 1173020011812 Switch I region; other site 1173020011813 G2 box; other site 1173020011814 G3 box; other site 1173020011815 Switch II region; other site 1173020011816 G4 box; other site 1173020011817 G5 box; other site 1173020011818 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1173020011819 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1173020011820 active site 1173020011821 catalytic site [active] 1173020011822 substrate binding site [chemical binding]; other site 1173020011823 O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445 1173020011824 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1173020011825 acyl-activating enzyme (AAE) consensus motif; other site 1173020011826 putative AMP binding site [chemical binding]; other site 1173020011827 putative active site [active] 1173020011828 putative CoA binding site [chemical binding]; other site 1173020011829 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 1173020011830 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1173020011831 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 1173020011832 homodimer interface [polypeptide binding]; other site 1173020011833 substrate-cofactor binding pocket; other site 1173020011834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020011835 catalytic residue [active] 1173020011836 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 1173020011837 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173020011838 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1173020011839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020011840 dimer interface [polypeptide binding]; other site 1173020011841 conserved gate region; other site 1173020011842 putative PBP binding loops; other site 1173020011843 ABC-ATPase subunit interface; other site 1173020011844 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 1173020011845 dimer interface [polypeptide binding]; other site 1173020011846 FMN binding site [chemical binding]; other site 1173020011847 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1173020011848 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1173020011849 cell division topological specificity factor MinE; Provisional; Region: PRK13988 1173020011850 septum site-determining protein MinD; Region: minD_bact; TIGR01968 1173020011851 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1173020011852 Switch I; other site 1173020011853 Switch II; other site 1173020011854 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1173020011855 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1173020011856 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1173020011857 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 1173020011858 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1173020011859 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020011860 Predicted esterase [General function prediction only]; Region: COG0400 1173020011861 putative hydrolase; Provisional; Region: PRK11460 1173020011862 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 1173020011863 Flavoprotein; Region: Flavoprotein; pfam02441 1173020011864 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1173020011865 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1173020011866 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020011867 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020011868 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1173020011869 Subunit I/III interface [polypeptide binding]; other site 1173020011870 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1173020011871 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 1173020011872 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1173020011873 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1173020011874 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1173020011875 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1173020011876 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1173020011877 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1173020011878 UbiA prenyltransferase family; Region: UbiA; pfam01040 1173020011879 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 1173020011880 Predicted membrane protein [Function unknown]; Region: COG4270 1173020011881 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1173020011882 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1173020011883 ring oligomerisation interface [polypeptide binding]; other site 1173020011884 ATP/Mg binding site [chemical binding]; other site 1173020011885 stacking interactions; other site 1173020011886 hinge regions; other site 1173020011887 AAA ATPase domain; Region: AAA_16; pfam13191 1173020011888 NB-ARC domain; Region: NB-ARC; pfam00931 1173020011889 WD domain, G-beta repeat; Region: WD40; pfam00400 1173020011890 WD40 repeats; Region: WD40; smart00320 1173020011891 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020011892 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020011893 structural tetrad; other site 1173020011894 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020011895 structural tetrad; other site 1173020011896 MAPEG family; Region: MAPEG; cl09190 1173020011897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1173020011898 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1173020011899 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1173020011900 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1173020011901 hinge; other site 1173020011902 active site 1173020011903 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1173020011904 putative ADP-ribose binding site [chemical binding]; other site 1173020011905 putative active site [active] 1173020011906 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1173020011907 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1173020011908 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1173020011909 elongation factor G; Reviewed; Region: PRK12740 1173020011910 G1 box; other site 1173020011911 putative GEF interaction site [polypeptide binding]; other site 1173020011912 GTP/Mg2+ binding site [chemical binding]; other site 1173020011913 Switch I region; other site 1173020011914 G2 box; other site 1173020011915 G3 box; other site 1173020011916 Switch II region; other site 1173020011917 G4 box; other site 1173020011918 G5 box; other site 1173020011919 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1173020011920 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1173020011921 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1173020011922 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1173020011923 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1173020011924 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1173020011925 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1173020011926 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1173020011927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 1173020011928 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1173020011929 dimer interface [polypeptide binding]; other site 1173020011930 active site 1173020011931 aspartate-rich active site metal binding site; other site 1173020011932 allosteric magnesium binding site [ion binding]; other site 1173020011933 Schiff base residues; other site 1173020011934 chaperone protein DnaJ; Provisional; Region: PRK14299 1173020011935 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173020011936 HSP70 interaction site [polypeptide binding]; other site 1173020011937 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1173020011938 substrate binding site [polypeptide binding]; other site 1173020011939 dimer interface [polypeptide binding]; other site 1173020011940 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1173020011941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020011942 S-adenosylmethionine binding site [chemical binding]; other site 1173020011943 cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665 1173020011944 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1173020011945 Cytochrome c; Region: Cytochrom_C; pfam00034 1173020011946 Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605 1173020011947 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1173020011948 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020011949 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020011950 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020011951 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1173020011952 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020011953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020011954 active site 1173020011955 phosphorylation site [posttranslational modification] 1173020011956 intermolecular recognition site; other site 1173020011957 dimerization interface [polypeptide binding]; other site 1173020011958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020011959 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020011960 active site 1173020011961 phosphorylation site [posttranslational modification] 1173020011962 intermolecular recognition site; other site 1173020011963 dimerization interface [polypeptide binding]; other site 1173020011964 CheW-like domain; Region: CheW; pfam01584 1173020011965 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173020011966 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173020011967 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173020011968 dimer interface [polypeptide binding]; other site 1173020011969 putative CheW interface [polypeptide binding]; other site 1173020011970 Hpt domain; Region: Hpt; pfam01627 1173020011971 putative binding surface; other site 1173020011972 active site 1173020011973 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173020011974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020011975 ATP binding site [chemical binding]; other site 1173020011976 Mg2+ binding site [ion binding]; other site 1173020011977 G-X-G motif; other site 1173020011978 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173020011979 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020011980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020011981 active site 1173020011982 phosphorylation site [posttranslational modification] 1173020011983 intermolecular recognition site; other site 1173020011984 dimerization interface [polypeptide binding]; other site 1173020011985 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1173020011986 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1173020011987 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1173020011988 Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941 1173020011989 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1173020011990 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1173020011991 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1173020011992 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1173020011993 putative NAD(P) binding site [chemical binding]; other site 1173020011994 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1173020011995 classical (c) SDRs; Region: SDR_c; cd05233 1173020011996 NAD(P) binding site [chemical binding]; other site 1173020011997 active site 1173020011998 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020011999 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020012000 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020012001 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020012002 Uncharacterized conserved protein [Function unknown]; Region: COG2006 1173020012003 Domain of unknown function (DUF362); Region: DUF362; pfam04015 1173020012004 hydrolase, alpha/beta fold family protein; Region: PLN02824 1173020012005 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1173020012006 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1173020012007 NAD(P) binding site [chemical binding]; other site 1173020012008 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173020012009 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173020012010 ligand binding site [chemical binding]; other site 1173020012011 flexible hinge region; other site 1173020012012 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173020012013 putative switch regulator; other site 1173020012014 non-specific DNA interactions [nucleotide binding]; other site 1173020012015 DNA binding site [nucleotide binding] 1173020012016 sequence specific DNA binding site [nucleotide binding]; other site 1173020012017 putative cAMP binding site [chemical binding]; other site 1173020012018 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1173020012019 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1173020012020 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1173020012021 trimer interface [polypeptide binding]; other site 1173020012022 active site 1173020012023 dimer interface [polypeptide binding]; other site 1173020012024 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020012025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020012026 active site 1173020012027 phosphorylation site [posttranslational modification] 1173020012028 intermolecular recognition site; other site 1173020012029 dimerization interface [polypeptide binding]; other site 1173020012030 PAS domain S-box; Region: sensory_box; TIGR00229 1173020012031 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020012032 putative active site [active] 1173020012033 heme pocket [chemical binding]; other site 1173020012034 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1173020012035 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020012036 putative active site [active] 1173020012037 heme pocket [chemical binding]; other site 1173020012038 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020012039 dimer interface [polypeptide binding]; other site 1173020012040 phosphorylation site [posttranslational modification] 1173020012041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020012042 ATP binding site [chemical binding]; other site 1173020012043 Mg2+ binding site [ion binding]; other site 1173020012044 G-X-G motif; other site 1173020012045 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020012046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020012047 active site 1173020012048 phosphorylation site [posttranslational modification] 1173020012049 intermolecular recognition site; other site 1173020012050 dimerization interface [polypeptide binding]; other site 1173020012051 CHASE3 domain; Region: CHASE3; cl05000 1173020012052 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020012053 PAS domain; Region: PAS_9; pfam13426 1173020012054 putative active site [active] 1173020012055 heme pocket [chemical binding]; other site 1173020012056 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020012057 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020012058 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020012059 dimer interface [polypeptide binding]; other site 1173020012060 phosphorylation site [posttranslational modification] 1173020012061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020012062 ATP binding site [chemical binding]; other site 1173020012063 Mg2+ binding site [ion binding]; other site 1173020012064 G-X-G motif; other site 1173020012065 YciI-like protein; Reviewed; Region: PRK12864 1173020012066 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 1173020012067 TM2 domain; Region: TM2; pfam05154 1173020012068 Short C-terminal domain; Region: SHOCT; pfam09851 1173020012069 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1173020012070 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173020012071 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173020012072 catalytic loop [active] 1173020012073 iron binding site [ion binding]; other site 1173020012074 Staphylococcal nuclease homologues; Region: SNc; smart00318 1173020012075 Catalytic site; other site 1173020012076 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1173020012077 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 1173020012078 Domain of unknown function DUF39; Region: DUF39; pfam01837 1173020012079 putative methanogenesis marker 16 metalloprotein; Region: methan_mark_16; TIGR03287 1173020012080 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1173020012081 (T/H)XGH motif; other site 1173020012082 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1173020012083 active site 1173020012084 phosphodiesterase YaeI; Provisional; Region: PRK11340 1173020012085 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1173020012086 putative active site [active] 1173020012087 putative metal binding site [ion binding]; other site 1173020012088 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1173020012089 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1173020012090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173020012091 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 1173020012092 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 1173020012093 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1173020012094 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1173020012095 mce related protein; Region: MCE; pfam02470 1173020012096 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 1173020012097 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1173020012098 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1173020012099 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1173020012100 substrate binding site [chemical binding]; other site 1173020012101 oxyanion hole (OAH) forming residues; other site 1173020012102 trimer interface [polypeptide binding]; other site 1173020012103 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1173020012104 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1173020012105 active site 1173020012106 HIGH motif; other site 1173020012107 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1173020012108 active site 1173020012109 KMSKS motif; other site 1173020012110 photosystem II protein K; Region: psbK; CHL00047 1173020012111 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 1173020012112 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1173020012113 B12 binding domain; Region: B12-binding; pfam02310 1173020012114 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173020012115 FeS/SAM binding site; other site 1173020012116 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173020012117 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173020012118 Predicted membrane protein [Function unknown]; Region: COG3431 1173020012119 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 1173020012120 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173020012121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 1173020012122 conserved hypothetical protein; Region: TIGR03492 1173020012123 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020012124 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173020012125 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 1173020012126 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 1173020012127 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 1173020012128 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1173020012129 active site 1173020012130 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 1173020012131 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173020012132 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020012133 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020012134 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173020012135 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1173020012136 dimer interface [polypeptide binding]; other site 1173020012137 active site 1173020012138 metal binding site [ion binding]; metal-binding site 1173020012139 glutathione binding site [chemical binding]; other site 1173020012140 enolase; Provisional; Region: eno; PRK00077 1173020012141 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1173020012142 dimer interface [polypeptide binding]; other site 1173020012143 metal binding site [ion binding]; metal-binding site 1173020012144 substrate binding pocket [chemical binding]; other site 1173020012145 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 1173020012146 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 1173020012147 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1173020012148 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1173020012149 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1173020012150 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1173020012151 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1173020012152 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1173020012153 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1173020012154 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1173020012155 dimer interface [polypeptide binding]; other site 1173020012156 active site 1173020012157 CoA binding pocket [chemical binding]; other site 1173020012158 putative phosphate acyltransferase; Provisional; Region: PRK05331 1173020012159 isoleucyl-tRNA synthetase; Region: PLN02843 1173020012160 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1173020012161 active site 1173020012162 HIGH motif; other site 1173020012163 nucleotide binding site [chemical binding]; other site 1173020012164 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1173020012165 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1173020012166 active site 1173020012167 KMSKS motif; other site 1173020012168 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1173020012169 tRNA binding surface [nucleotide binding]; other site 1173020012170 anticodon binding site; other site 1173020012171 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 1173020012172 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1173020012173 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1173020012174 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020012175 putative active site [active] 1173020012176 heme pocket [chemical binding]; other site 1173020012177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020012178 dimer interface [polypeptide binding]; other site 1173020012179 phosphorylation site [posttranslational modification] 1173020012180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020012181 ATP binding site [chemical binding]; other site 1173020012182 Mg2+ binding site [ion binding]; other site 1173020012183 G-X-G motif; other site 1173020012184 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020012185 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 1173020012186 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 1173020012187 HEAT repeats; Region: HEAT_2; pfam13646 1173020012188 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 1173020012189 HEAT repeats; Region: HEAT_2; pfam13646 1173020012190 protein binding surface [polypeptide binding]; other site 1173020012191 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 1173020012192 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1173020012193 DNA binding site [nucleotide binding] 1173020012194 catalytic residue [active] 1173020012195 H2TH interface [polypeptide binding]; other site 1173020012196 putative catalytic residues [active] 1173020012197 turnover-facilitating residue; other site 1173020012198 intercalation triad [nucleotide binding]; other site 1173020012199 8OG recognition residue [nucleotide binding]; other site 1173020012200 putative reading head residues; other site 1173020012201 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1173020012202 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1173020012203 photosystem I reaction center subunit IV; Provisional; Region: PRK02749 1173020012204 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1173020012205 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1173020012206 DHH family; Region: DHH; pfam01368 1173020012207 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1173020012208 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1173020012209 active site 1173020012210 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1173020012211 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1173020012212 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020012213 structural tetrad; other site 1173020012214 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1173020012215 Peptidase family M23; Region: Peptidase_M23; pfam01551 1173020012216 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1173020012217 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1173020012218 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 1173020012219 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1173020012220 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1173020012221 metal binding site 2 [ion binding]; metal-binding site 1173020012222 putative DNA binding helix; other site 1173020012223 metal binding site 1 [ion binding]; metal-binding site 1173020012224 dimer interface [polypeptide binding]; other site 1173020012225 structural Zn2+ binding site [ion binding]; other site 1173020012226 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 1173020012227 DNA photolyase; Region: DNA_photolyase; pfam00875 1173020012228 Predicted transcriptional regulators [Transcription]; Region: COG1695 1173020012229 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1173020012230 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 1173020012231 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1173020012232 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020012233 motif II; other site 1173020012234 Protein of unknown function (DUF416); Region: DUF416; cl01166 1173020012235 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1173020012236 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1173020012237 active site 1173020012238 Zn binding site [ion binding]; other site 1173020012239 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1173020012240 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 1173020012241 active site 1173020012242 Zn binding site [ion binding]; other site 1173020012243 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 1173020012244 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1173020012245 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1173020012246 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1173020012247 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173020012248 C-terminal domain interface [polypeptide binding]; other site 1173020012249 GSH binding site (G-site) [chemical binding]; other site 1173020012250 dimer interface [polypeptide binding]; other site 1173020012251 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1173020012252 N-terminal domain interface [polypeptide binding]; other site 1173020012253 dimer interface [polypeptide binding]; other site 1173020012254 substrate binding pocket (H-site) [chemical binding]; other site 1173020012255 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567 1173020012256 hypothetical protein; Provisional; Region: PRK07377 1173020012257 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 1173020012258 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 1173020012259 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173020012260 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08389 1173020012261 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 1173020012262 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1173020012263 DNA binding residues [nucleotide binding] 1173020012264 dimer interface [polypeptide binding]; other site 1173020012265 metal binding site [ion binding]; metal-binding site 1173020012266 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1173020012267 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1173020012268 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173020012269 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1173020012270 Walker A/P-loop; other site 1173020012271 ATP binding site [chemical binding]; other site 1173020012272 Q-loop/lid; other site 1173020012273 ABC transporter signature motif; other site 1173020012274 Walker B; other site 1173020012275 D-loop; other site 1173020012276 H-loop/switch region; other site 1173020012277 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173020012278 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1173020012279 Walker A/P-loop; other site 1173020012280 ATP binding site [chemical binding]; other site 1173020012281 Q-loop/lid; other site 1173020012282 ABC transporter signature motif; other site 1173020012283 Walker B; other site 1173020012284 D-loop; other site 1173020012285 H-loop/switch region; other site 1173020012286 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173020012287 NMT1-like family; Region: NMT1_2; pfam13379 1173020012288 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1173020012289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020012290 dimer interface [polypeptide binding]; other site 1173020012291 conserved gate region; other site 1173020012292 ABC-ATPase subunit interface; other site 1173020012293 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173020012294 NMT1-like family; Region: NMT1_2; pfam13379 1173020012295 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1173020012296 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173020012297 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 1173020012298 putative dimerization interface [polypeptide binding]; other site 1173020012299 Peptidase family M48; Region: Peptidase_M48; cl12018 1173020012300 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173020012301 TPR motif; other site 1173020012302 binding surface 1173020012303 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1173020012304 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1173020012305 active site 1173020012306 NTP binding site [chemical binding]; other site 1173020012307 metal binding triad [ion binding]; metal-binding site 1173020012308 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1173020012309 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1173020012310 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 1173020012311 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1173020012312 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1173020012313 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1173020012314 phosphate binding site [ion binding]; other site 1173020012315 putative substrate binding pocket [chemical binding]; other site 1173020012316 dimer interface [polypeptide binding]; other site 1173020012317 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1173020012318 active site 1173020012319 putative DNA-binding cleft [nucleotide binding]; other site 1173020012320 dimer interface [polypeptide binding]; other site 1173020012321 Protein kinase domain; Region: Pkinase; pfam00069 1173020012322 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020012323 active site 1173020012324 ATP binding site [chemical binding]; other site 1173020012325 substrate binding site [chemical binding]; other site 1173020012326 activation loop (A-loop); other site 1173020012327 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020012328 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020012329 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020012330 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020012331 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1173020012332 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1173020012333 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173020012334 Coenzyme A binding pocket [chemical binding]; other site 1173020012335 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1173020012336 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1173020012337 catalytic site [active] 1173020012338 putative active site [active] 1173020012339 putative substrate binding site [chemical binding]; other site 1173020012340 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1173020012341 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1173020012342 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 1173020012343 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 1173020012344 ribonuclease PH; Reviewed; Region: rph; PRK00173 1173020012345 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1173020012346 hexamer interface [polypeptide binding]; other site 1173020012347 active site 1173020012348 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020012349 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020012350 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020012351 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020012352 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1173020012353 Protein of unknown function DUF58; Region: DUF58; pfam01882 1173020012354 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173020012355 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020012356 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020012357 TPR repeat; Region: TPR_11; pfam13414 1173020012358 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173020012359 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1173020012360 MoaE interaction surface [polypeptide binding]; other site 1173020012361 MoeB interaction surface [polypeptide binding]; other site 1173020012362 thiocarboxylated glycine; other site 1173020012363 light-harvesting-like protein 3; Provisional; Region: PLN00014 1173020012364 light-harvesting-like protein 3; Provisional; Region: PLN00014 1173020012365 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1173020012366 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 1173020012367 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1173020012368 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1173020012369 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1173020012370 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 1173020012371 Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480 1173020012372 Pheophorbide a oxygenase; Region: PaO; pfam08417 1173020012373 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1173020012374 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1173020012375 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1173020012376 G1 box; other site 1173020012377 GTP/Mg2+ binding site [chemical binding]; other site 1173020012378 Switch I region; other site 1173020012379 G2 box; other site 1173020012380 Switch II region; other site 1173020012381 G3 box; other site 1173020012382 G4 box; other site 1173020012383 G5 box; other site 1173020012384 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1173020012385 photosystem I subunit VIII; Validated; Region: psaI; CHL00186 1173020012386 photosystem II reaction center protein J; Provisional; Region: PRK02565 1173020012387 photosystem II reaction center L; Provisional; Region: psbL; PRK00753 1173020012388 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 1173020012389 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 1173020012390 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 1173020012391 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 1173020012392 Ycf48-like protein; Provisional; Region: PRK13684 1173020012393 Rubredoxin; Region: Rubredoxin; pfam00301 1173020012394 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1173020012395 iron binding site [ion binding]; other site 1173020012396 calcium/proton exchanger (cax); Region: cax; TIGR00378 1173020012397 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1173020012398 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1173020012399 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 1173020012400 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173020012401 catalytic residues [active] 1173020012402 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1173020012403 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173020012404 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1173020012405 Leucine rich repeat; Region: LRR_8; pfam13855 1173020012406 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 1173020012407 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 1173020012408 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1173020012409 Zn2+ binding site [ion binding]; other site 1173020012410 Mg2+ binding site [ion binding]; other site 1173020012411 Oligomerisation domain; Region: Oligomerisation; pfam02410 1173020012412 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 1173020012413 L-asparaginase II; Region: Asparaginase_II; pfam06089 1173020012414 seryl-tRNA synthetase; Provisional; Region: PRK05431 1173020012415 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1173020012416 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1173020012417 dimer interface [polypeptide binding]; other site 1173020012418 active site 1173020012419 motif 1; other site 1173020012420 motif 2; other site 1173020012421 motif 3; other site 1173020012422 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1173020012423 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1173020012424 catalytic site [active] 1173020012425 G-X2-G-X-G-K; other site 1173020012426 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173020012427 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173020012428 catalytic loop [active] 1173020012429 iron binding site [ion binding]; other site 1173020012430 Phycobilisome protein; Region: Phycobilisome; cl08227 1173020012431 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 1173020012432 V4R domain; Region: V4R; pfam02830 1173020012433 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173020012434 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173020012435 catalytic loop [active] 1173020012436 iron binding site [ion binding]; other site 1173020012437 Circadian oscillating protein COP23; Region: COP23; pfam14218 1173020012438 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173020012439 16S rRNA methyltransferase B; Provisional; Region: PRK14901 1173020012440 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1173020012441 putative RNA binding site [nucleotide binding]; other site 1173020012442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020012443 S-adenosylmethionine binding site [chemical binding]; other site 1173020012444 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1173020012445 UreF; Region: UreF; pfam01730 1173020012446 Proline dehydrogenase; Region: Pro_dh; cl03282 1173020012447 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1173020012448 delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237 1173020012449 Glutamate binding site [chemical binding]; other site 1173020012450 homodimer interface [polypeptide binding]; other site 1173020012451 NAD binding site [chemical binding]; other site 1173020012452 catalytic residues [active] 1173020012453 HEAT repeats; Region: HEAT_2; pfam13646 1173020012454 HEAT repeats; Region: HEAT_2; pfam13646 1173020012455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173020012456 NAD(P) binding site [chemical binding]; other site 1173020012457 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 1173020012458 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020012459 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1173020012460 pentamer interface [polypeptide binding]; other site 1173020012461 dodecaamer interface [polypeptide binding]; other site 1173020012462 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1173020012463 rod shape-determining protein MreB; Provisional; Region: PRK13927 1173020012464 MreB and similar proteins; Region: MreB_like; cd10225 1173020012465 nucleotide binding site [chemical binding]; other site 1173020012466 Mg binding site [ion binding]; other site 1173020012467 putative protofilament interaction site [polypeptide binding]; other site 1173020012468 RodZ interaction site [polypeptide binding]; other site 1173020012469 rod shape-determining protein MreC; Provisional; Region: PRK13922 1173020012470 rod shape-determining protein MreC; Region: MreC; pfam04085 1173020012471 rod shape-determining protein MreD; Region: MreD; cl01087 1173020012472 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173020012473 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020012474 active site 1173020012475 ATP binding site [chemical binding]; other site 1173020012476 substrate binding site [chemical binding]; other site 1173020012477 activation loop (A-loop); other site 1173020012478 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020012479 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020012480 structural tetrad; other site 1173020012481 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 1173020012482 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 1173020012483 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1173020012484 active site 1173020012485 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1173020012486 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1173020012487 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1173020012488 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1173020012489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1173020012490 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1173020012491 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1173020012492 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1173020012493 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1173020012494 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1173020012495 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1173020012496 metal ion-dependent adhesion site (MIDAS); other site 1173020012497 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 1173020012498 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1173020012499 SnoaL-like domain; Region: SnoaL_2; pfam12680 1173020012500 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1173020012501 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1173020012502 mRNA/rRNA interface [nucleotide binding]; other site 1173020012503 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1173020012504 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1173020012505 23S rRNA interface [nucleotide binding]; other site 1173020012506 L7/L12 interface [polypeptide binding]; other site 1173020012507 putative thiostrepton binding site; other site 1173020012508 L25 interface [polypeptide binding]; other site 1173020012509 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1173020012510 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1173020012511 putative homodimer interface [polypeptide binding]; other site 1173020012512 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1173020012513 heterodimer interface [polypeptide binding]; other site 1173020012514 homodimer interface [polypeptide binding]; other site 1173020012515 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1173020012516 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1173020012517 peripheral dimer interface [polypeptide binding]; other site 1173020012518 core dimer interface [polypeptide binding]; other site 1173020012519 L10 interface [polypeptide binding]; other site 1173020012520 L11 interface [polypeptide binding]; other site 1173020012521 putative EF-Tu interaction site [polypeptide binding]; other site 1173020012522 putative EF-G interaction site [polypeptide binding]; other site 1173020012523 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1173020012524 23S rRNA interface [nucleotide binding]; other site 1173020012525 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1173020012526 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 1173020012527 2TM domain; Region: 2TM; pfam13239 1173020012528 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 1173020012529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020012530 Walker A/P-loop; other site 1173020012531 ATP binding site [chemical binding]; other site 1173020012532 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1173020012533 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1173020012534 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1173020012535 Aluminium resistance protein; Region: Alum_res; pfam06838 1173020012536 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1173020012537 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1173020012538 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1173020012539 Di-iron ligands [ion binding]; other site 1173020012540 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1173020012541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020012542 S-adenosylmethionine binding site [chemical binding]; other site 1173020012543 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1173020012544 Zn2+ binding site [ion binding]; other site 1173020012545 Mg2+ binding site [ion binding]; other site 1173020012546 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1173020012547 precorrin-3B synthase; Region: CobG; TIGR02435 1173020012548 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1173020012549 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1173020012550 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1173020012551 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1173020012552 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1173020012553 active site 1173020012554 SAM binding site [chemical binding]; other site 1173020012555 homodimer interface [polypeptide binding]; other site 1173020012556 RNA ligase; Region: RNA_lig_T4_1; pfam09511 1173020012557 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1173020012558 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1173020012559 dimer interface [polypeptide binding]; other site 1173020012560 putative functional site; other site 1173020012561 putative MPT binding site; other site 1173020012562 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1173020012563 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1173020012564 active site 1173020012565 Substrate binding site; other site 1173020012566 Mg++ binding site; other site 1173020012567 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1173020012568 putative trimer interface [polypeptide binding]; other site 1173020012569 putative CoA binding site [chemical binding]; other site 1173020012570 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1173020012571 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 1173020012572 NAD synthetase; Provisional; Region: PRK13981 1173020012573 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1173020012574 multimer interface [polypeptide binding]; other site 1173020012575 active site 1173020012576 catalytic triad [active] 1173020012577 protein interface 1 [polypeptide binding]; other site 1173020012578 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1173020012579 homodimer interface [polypeptide binding]; other site 1173020012580 NAD binding pocket [chemical binding]; other site 1173020012581 ATP binding pocket [chemical binding]; other site 1173020012582 Mg binding site [ion binding]; other site 1173020012583 active-site loop [active] 1173020012584 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1173020012585 nudix motif; other site 1173020012586 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1173020012587 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1173020012588 active site 1173020012589 (T/H)XGH motif; other site 1173020012590 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020012591 Exoribonuclease R [Transcription]; Region: VacB; COG0557 1173020012592 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1173020012593 RNB domain; Region: RNB; pfam00773 1173020012594 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1173020012595 RNA binding site [nucleotide binding]; other site 1173020012596 aromatic acid decarboxylase; Validated; Region: PRK05920 1173020012597 Flavoprotein; Region: Flavoprotein; pfam02441 1173020012598 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 1173020012599 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173020012600 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1173020012601 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1173020012602 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 1173020012603 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 1173020012604 G1 box; other site 1173020012605 GTP/Mg2+ binding site [chemical binding]; other site 1173020012606 Switch I region; other site 1173020012607 G2 box; other site 1173020012608 Switch II region; other site 1173020012609 G3 box; other site 1173020012610 G4 box; other site 1173020012611 G5 box; other site 1173020012612 Domain of unknown function (DUF697); Region: DUF697; pfam05128 1173020012613 M28 Zn-Peptidases; Region: M28_like_1; cd05640 1173020012614 Peptidase family M28; Region: Peptidase_M28; pfam04389 1173020012615 metal binding site [ion binding]; metal-binding site 1173020012616 MarC family integral membrane protein; Region: MarC; pfam01914 1173020012617 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1173020012618 propionate/acetate kinase; Provisional; Region: PRK12379 1173020012619 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1173020012620 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1173020012621 [2Fe-2S] cluster binding site [ion binding]; other site 1173020012622 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1173020012623 hydrophobic ligand binding site; other site 1173020012624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1173020012625 citrate synthase; Provisional; Region: PRK14036 1173020012626 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1173020012627 oxalacetate binding site [chemical binding]; other site 1173020012628 citrylCoA binding site [chemical binding]; other site 1173020012629 coenzyme A binding site [chemical binding]; other site 1173020012630 catalytic triad [active] 1173020012631 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 1173020012632 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 1173020012633 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020012634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020012635 ATP binding site [chemical binding]; other site 1173020012636 Mg2+ binding site [ion binding]; other site 1173020012637 G-X-G motif; other site 1173020012638 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1173020012639 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1173020012640 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173020012641 catalytic residue [active] 1173020012642 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 1173020012643 PLD-like domain; Region: PLDc_2; pfam13091 1173020012644 putative active site [active] 1173020012645 catalytic site [active] 1173020012646 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 1173020012647 PLD-like domain; Region: PLDc_2; pfam13091 1173020012648 putative active site [active] 1173020012649 catalytic site [active] 1173020012650 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1173020012651 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 1173020012652 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1173020012653 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1173020012654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 1173020012655 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 1173020012656 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 1173020012657 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1173020012658 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1173020012659 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 1173020012660 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 1173020012661 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 1173020012662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020012663 TPR repeat; Region: TPR_11; pfam13414 1173020012664 binding surface 1173020012665 TPR motif; other site 1173020012666 TPR repeat; Region: TPR_11; pfam13414 1173020012667 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020012668 binding surface 1173020012669 TPR motif; other site 1173020012670 TPR repeat; Region: TPR_11; pfam13414 1173020012671 TROVE domain; Region: TROVE; pfam05731 1173020012672 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1173020012673 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1173020012674 putative metal binding site [ion binding]; other site 1173020012675 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1173020012676 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1173020012677 putative metal binding site [ion binding]; other site 1173020012678 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1173020012679 active site 1173020012680 Integral membrane protein TerC family; Region: TerC; cl10468 1173020012681 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1173020012682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020012683 dimer interface [polypeptide binding]; other site 1173020012684 conserved gate region; other site 1173020012685 ABC-ATPase subunit interface; other site 1173020012686 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1173020012687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020012688 Walker A/P-loop; other site 1173020012689 ATP binding site [chemical binding]; other site 1173020012690 Q-loop/lid; other site 1173020012691 ABC transporter signature motif; other site 1173020012692 Walker B; other site 1173020012693 D-loop; other site 1173020012694 H-loop/switch region; other site 1173020012695 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1173020012696 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1173020012697 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1173020012698 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1173020012699 P-loop, Walker A motif; other site 1173020012700 Base recognition motif; other site 1173020012701 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1173020012702 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020012703 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1173020012704 structural tetrad; other site 1173020012705 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1173020012706 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1173020012707 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1173020012708 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1173020012709 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173020012710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020012711 S-adenosylmethionine binding site [chemical binding]; other site 1173020012712 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1173020012713 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1173020012714 dimer interface [polypeptide binding]; other site 1173020012715 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1173020012716 active site 1173020012717 Fe binding site [ion binding]; other site 1173020012718 Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249 1173020012719 tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887 1173020012720 UbiA prenyltransferase family; Region: UbiA; pfam01040 1173020012721 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 1173020012722 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1173020012723 Hemerythrin-like domain; Region: Hr-like; cd12108 1173020012724 Fe binding site [ion binding]; other site 1173020012725 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1173020012726 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173020012727 non-specific DNA binding site [nucleotide binding]; other site 1173020012728 salt bridge; other site 1173020012729 sequence-specific DNA binding site [nucleotide binding]; other site 1173020012730 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1173020012731 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1173020012732 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 1173020012733 interchain domain interface [polypeptide binding]; other site 1173020012734 intrachain domain interface; other site 1173020012735 Qi binding site; other site 1173020012736 Qo binding site; other site 1173020012737 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1173020012738 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1173020012739 Qi binding site; other site 1173020012740 intrachain domain interface; other site 1173020012741 interchain domain interface [polypeptide binding]; other site 1173020012742 heme bH binding site [chemical binding]; other site 1173020012743 heme bL binding site [chemical binding]; other site 1173020012744 Qo binding site; other site 1173020012745 carboxyl-terminal processing protease; Provisional; Region: PLN00049 1173020012746 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1173020012747 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1173020012748 protein binding site [polypeptide binding]; other site 1173020012749 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1173020012750 Catalytic dyad [active] 1173020012751 DHH family; Region: DHH; pfam01368 1173020012752 FOG: CBS domain [General function prediction only]; Region: COG0517 1173020012753 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 1173020012754 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1173020012755 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1173020012756 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1173020012757 active site 1173020012758 NTP binding site [chemical binding]; other site 1173020012759 metal binding triad [ion binding]; metal-binding site 1173020012760 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 1173020012761 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 1173020012762 PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990 1173020012763 protein binding site [polypeptide binding]; other site 1173020012764 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1173020012765 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1173020012766 P loop; other site 1173020012767 Nucleotide binding site [chemical binding]; other site 1173020012768 DTAP/Switch II; other site 1173020012769 Switch I; other site 1173020012770 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1173020012771 putative dimer interface [polypeptide binding]; other site 1173020012772 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 1173020012773 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1173020012774 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1173020012775 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1173020012776 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1173020012777 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1173020012778 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1173020012779 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1173020012780 active site 1173020012781 catalytic residues [active] 1173020012782 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 1173020012783 Photosystem I protein M (PsaM); Region: PsaM; cl15374 1173020012784 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1173020012785 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1173020012786 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173020012787 Ligand Binding Site [chemical binding]; other site 1173020012788 Protein of unknown function (DUF565); Region: DUF565; pfam04483 1173020012789 hypothetical protein; Provisional; Region: PRK02509 1173020012790 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1173020012791 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1173020012792 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1173020012793 nucleotide binding pocket [chemical binding]; other site 1173020012794 K-X-D-G motif; other site 1173020012795 catalytic site [active] 1173020012796 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1173020012797 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1173020012798 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1173020012799 Dimer interface [polypeptide binding]; other site 1173020012800 BRCT sequence motif; other site 1173020012801 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173020012802 Ligand Binding Site [chemical binding]; other site 1173020012803 Phosphoglycerate kinase; Region: PGK; pfam00162 1173020012804 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1173020012805 substrate binding site [chemical binding]; other site 1173020012806 hinge regions; other site 1173020012807 ADP binding site [chemical binding]; other site 1173020012808 catalytic site [active] 1173020012809 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1173020012810 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1173020012811 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1173020012812 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1173020012813 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1173020012814 active site 1173020012815 hydrophilic channel; other site 1173020012816 dimerization interface [polypeptide binding]; other site 1173020012817 catalytic residues [active] 1173020012818 active site lid [active] 1173020012819 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 1173020012820 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1173020012821 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1173020012822 Walker A/P-loop; other site 1173020012823 ATP binding site [chemical binding]; other site 1173020012824 Q-loop/lid; other site 1173020012825 ABC transporter signature motif; other site 1173020012826 Walker B; other site 1173020012827 D-loop; other site 1173020012828 H-loop/switch region; other site 1173020012829 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1173020012830 Walker A/P-loop; other site 1173020012831 ATP binding site [chemical binding]; other site 1173020012832 Q-loop/lid; other site 1173020012833 ABC transporter signature motif; other site 1173020012834 Walker B; other site 1173020012835 D-loop; other site 1173020012836 H-loop/switch region; other site 1173020012837 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1173020012838 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173020012839 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173020012840 catalytic residues [active] 1173020012841 Predicted membrane protein [Function unknown]; Region: COG4094 1173020012842 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173020012843 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1173020012844 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1173020012845 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1173020012846 B12 binding site [chemical binding]; other site 1173020012847 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173020012848 FeS/SAM binding site; other site 1173020012849 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 1173020012850 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 1173020012851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 1173020012852 Protein of unknown function (DUF433); Region: DUF433; pfam04255 1173020012853 CAAX protease self-immunity; Region: Abi; pfam02517 1173020012854 arginine decarboxylase; Provisional; Region: PRK05354 1173020012855 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1173020012856 dimer interface [polypeptide binding]; other site 1173020012857 active site 1173020012858 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1173020012859 catalytic residues [active] 1173020012860 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1173020012861 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1173020012862 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173020012863 recombination protein RecR; Reviewed; Region: recR; PRK00076 1173020012864 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 1173020012865 RecR protein; Region: RecR; pfam02132 1173020012866 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1173020012867 putative active site [active] 1173020012868 putative metal-binding site [ion binding]; other site 1173020012869 tetramer interface [polypeptide binding]; other site 1173020012870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020012871 active site 1173020012872 phosphorylation site [posttranslational modification] 1173020012873 intermolecular recognition site; other site 1173020012874 lipoyl synthase; Provisional; Region: PRK12928 1173020012875 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173020012876 FeS/SAM binding site; other site 1173020012877 competence damage-inducible protein A; Provisional; Region: PRK00549 1173020012878 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1173020012879 putative MPT binding site; other site 1173020012880 Competence-damaged protein; Region: CinA; pfam02464 1173020012881 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 1173020012882 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1173020012883 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1173020012884 putative sugar binding sites [chemical binding]; other site 1173020012885 Q-X-W motif; other site 1173020012886 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 1173020012887 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1173020012888 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1173020012889 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 1173020012890 protein I interface; other site 1173020012891 D2 interface; other site 1173020012892 protein T interface; other site 1173020012893 chlorophyll binding site; other site 1173020012894 beta carotene binding site; other site 1173020012895 pheophytin binding site; other site 1173020012896 manganese-stabilizing polypeptide interface; other site 1173020012897 CP43 interface; other site 1173020012898 protein L interface; other site 1173020012899 oxygen evolving complex binding site; other site 1173020012900 bromide binding site; other site 1173020012901 quinone binding site; other site 1173020012902 Fe binding site [ion binding]; other site 1173020012903 core light harvesting interface; other site 1173020012904 cytochrome b559 alpha subunit interface; other site 1173020012905 cytochrome c-550 interface; other site 1173020012906 protein J interface; other site 1173020012907 arogenate dehydrogenase; Reviewed; Region: PRK07417 1173020012908 prephenate dehydrogenase; Validated; Region: PRK08507 1173020012909 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 1173020012910 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 1173020012911 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1173020012912 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1173020012913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020012914 S-adenosylmethionine binding site [chemical binding]; other site 1173020012915 Tic22-like family; Region: Tic22; cl04468 1173020012916 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1173020012917 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1173020012918 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1173020012919 RNA binding surface [nucleotide binding]; other site 1173020012920 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1173020012921 active site 1173020012922 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173020012923 non-specific DNA binding site [nucleotide binding]; other site 1173020012924 salt bridge; other site 1173020012925 sequence-specific DNA binding site [nucleotide binding]; other site 1173020012926 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1173020012927 Clp protease ATP binding subunit; Region: clpC; CHL00095 1173020012928 Clp amino terminal domain; Region: Clp_N; pfam02861 1173020012929 Clp amino terminal domain; Region: Clp_N; pfam02861 1173020012930 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020012931 Walker A motif; other site 1173020012932 ATP binding site [chemical binding]; other site 1173020012933 Walker B motif; other site 1173020012934 arginine finger; other site 1173020012935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020012936 Walker A motif; other site 1173020012937 ATP binding site [chemical binding]; other site 1173020012938 Walker B motif; other site 1173020012939 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1173020012940 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1173020012941 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020012942 active site 1173020012943 ATP binding site [chemical binding]; other site 1173020012944 substrate binding site [chemical binding]; other site 1173020012945 activation loop (A-loop); other site 1173020012946 Uncharacterized subfamily of glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798 1173020012947 active site 1173020012948 catalytic site [active] 1173020012949 Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622 1173020012950 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1173020012951 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1173020012952 signal recognition particle protein; Provisional; Region: PRK10867 1173020012953 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1173020012954 active site 1173020012955 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1173020012956 substrate binding site [chemical binding]; other site 1173020012957 metal binding site [ion binding]; metal-binding site 1173020012958 glycogen branching enzyme; Provisional; Region: PRK05402 1173020012959 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1173020012960 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1173020012961 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1173020012962 active site 1173020012963 catalytic site [active] 1173020012964 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1173020012965 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 1173020012966 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 1173020012967 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 1173020012968 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1173020012969 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 1173020012970 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1173020012971 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1173020012972 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1173020012973 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1173020012974 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1173020012975 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1173020012976 metabolite-proton symporter; Region: 2A0106; TIGR00883 1173020012977 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 1173020012978 ArsC family; Region: ArsC; pfam03960 1173020012979 catalytic residue [active] 1173020012980 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173020012981 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173020012982 metal binding site [ion binding]; metal-binding site 1173020012983 active site 1173020012984 I-site; other site 1173020012985 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173020012986 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1173020012987 FAD binding domain; Region: FAD_binding_4; pfam01565 1173020012988 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1173020012989 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1173020012990 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1173020012991 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 1173020012992 membrane protein; Provisional; Region: PRK14419 1173020012993 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 1173020012994 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1173020012995 Ribonuclease P; Region: Ribonuclease_P; cl00457 1173020012996 Bacterial PH domain; Region: DUF304; pfam03703 1173020012997 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 1173020012998 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1173020012999 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1173020013000 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1173020013001 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1173020013002 G-X-X-G motif; other site 1173020013003 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1173020013004 RxxxH motif; other site 1173020013005 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1173020013006 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1173020013007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1173020013008 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1173020013009 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1173020013010 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1173020013011 putative trimer interface [polypeptide binding]; other site 1173020013012 putative CoA binding site [chemical binding]; other site 1173020013013 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 1173020013014 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020013015 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173020013016 Coenzyme A binding pocket [chemical binding]; other site 1173020013017 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 1173020013018 RNA polymerase sigma factor SigC; Validated; Region: PRK07598 1173020013019 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1173020013020 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173020013021 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173020013022 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173020013023 DNA binding residues [nucleotide binding] 1173020013024 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173020013025 HSP70 interaction site [polypeptide binding]; other site 1173020013026 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020013027 putative active site [active] 1173020013028 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1173020013029 homodimer interface [polypeptide binding]; other site 1173020013030 substrate-cofactor binding pocket; other site 1173020013031 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1173020013032 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020013033 catalytic residue [active] 1173020013034 FtsH Extracellular; Region: FtsH_ext; pfam06480 1173020013035 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1173020013036 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020013037 Walker A motif; other site 1173020013038 ATP binding site [chemical binding]; other site 1173020013039 Walker B motif; other site 1173020013040 arginine finger; other site 1173020013041 Peptidase family M41; Region: Peptidase_M41; pfam01434 1173020013042 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1173020013043 active site 1173020013044 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 1173020013045 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173020013046 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1173020013047 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1173020013048 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1173020013049 hypothetical protein; Validated; Region: PRK07411 1173020013050 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1173020013051 ATP binding site [chemical binding]; other site 1173020013052 substrate interface [chemical binding]; other site 1173020013053 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1173020013054 active site residue [active] 1173020013055 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1173020013056 ribosomal protein L21; Region: rpl21; CHL00075 1173020013057 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1173020013058 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1173020013059 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1173020013060 Transposase domain (DUF772); Region: DUF772; pfam05598 1173020013061 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020013062 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1173020013063 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1173020013064 NlpC/P60 family; Region: NLPC_P60; pfam00877 1173020013065 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173020013066 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173020013067 DNA binding residues [nucleotide binding] 1173020013068 dimerization interface [polypeptide binding]; other site 1173020013069 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 1173020013070 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173020013071 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1173020013072 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1173020013073 putative active site [active] 1173020013074 substrate binding site [chemical binding]; other site 1173020013075 putative cosubstrate binding site; other site 1173020013076 catalytic site [active] 1173020013077 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1173020013078 substrate binding site [chemical binding]; other site 1173020013079 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1173020013080 PhoU domain; Region: PhoU; pfam01895 1173020013081 PhoU domain; Region: PhoU; pfam01895 1173020013082 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173020013083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020013084 dimer interface [polypeptide binding]; other site 1173020013085 phosphorylation site [posttranslational modification] 1173020013086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020013087 ATP binding site [chemical binding]; other site 1173020013088 Mg2+ binding site [ion binding]; other site 1173020013089 G-X-G motif; other site 1173020013090 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 1173020013091 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1173020013092 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1173020013093 GTP binding site; other site 1173020013094 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 1173020013095 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020013096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020013097 active site 1173020013098 phosphorylation site [posttranslational modification] 1173020013099 intermolecular recognition site; other site 1173020013100 dimerization interface [polypeptide binding]; other site 1173020013101 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020013102 DNA binding site [nucleotide binding] 1173020013103 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1173020013104 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173020013105 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1173020013106 YHYH protein; Region: YHYH; pfam14240 1173020013107 quinolinate synthetase; Provisional; Region: PRK09375 1173020013108 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1173020013109 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1173020013110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020013111 catalytic residue [active] 1173020013112 4-alpha-glucanotransferase; Provisional; Region: PRK14508 1173020013113 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1173020013114 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020013115 Coenzyme A binding pocket [chemical binding]; other site 1173020013116 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1173020013117 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1173020013118 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1173020013119 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1173020013120 GxxExxY protein; Region: GxxExxY; TIGR04256 1173020013121 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1173020013122 catalytic residue [active] 1173020013123 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1173020013124 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1173020013125 NAD(P) binding site [chemical binding]; other site 1173020013126 putative active site [active] 1173020013127 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 1173020013128 D-xylulose kinase; Region: XylB; TIGR01312 1173020013129 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1173020013130 nucleotide binding site [chemical binding]; other site 1173020013131 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1173020013132 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1173020013133 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173020013134 catalytic core [active] 1173020013135 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1173020013136 Sm and related proteins; Region: Sm_like; cl00259 1173020013137 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1173020013138 putative oligomer interface [polypeptide binding]; other site 1173020013139 putative RNA binding site [nucleotide binding]; other site 1173020013140 NusA N-terminal domain; Region: NusA_N; pfam08529 1173020013141 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1173020013142 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1173020013143 RNA binding site [nucleotide binding]; other site 1173020013144 homodimer interface [polypeptide binding]; other site 1173020013145 NusA-like KH domain; Region: KH_5; pfam13184 1173020013146 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1173020013147 G-X-X-G motif; other site 1173020013148 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020013149 Coenzyme A binding pocket [chemical binding]; other site 1173020013150 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1173020013151 putative RNA binding cleft [nucleotide binding]; other site 1173020013152 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1173020013153 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020013154 putative active site [active] 1173020013155 heme pocket [chemical binding]; other site 1173020013156 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020013157 dimer interface [polypeptide binding]; other site 1173020013158 phosphorylation site [posttranslational modification] 1173020013159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020013160 ATP binding site [chemical binding]; other site 1173020013161 Mg2+ binding site [ion binding]; other site 1173020013162 G-X-G motif; other site 1173020013163 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020013164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020013165 active site 1173020013166 phosphorylation site [posttranslational modification] 1173020013167 intermolecular recognition site; other site 1173020013168 dimerization interface [polypeptide binding]; other site 1173020013169 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1173020013170 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 1173020013171 putative active site [active] 1173020013172 putative NTP binding site [chemical binding]; other site 1173020013173 putative nucleic acid binding site [nucleotide binding]; other site 1173020013174 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173020013175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020013176 active site 1173020013177 phosphorylation site [posttranslational modification] 1173020013178 intermolecular recognition site; other site 1173020013179 dimerization interface [polypeptide binding]; other site 1173020013180 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173020013181 DNA binding residues [nucleotide binding] 1173020013182 dimerization interface [polypeptide binding]; other site 1173020013183 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1173020013184 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1173020013185 Uncharacterized conserved protein [Function unknown]; Region: COG2928 1173020013186 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1173020013187 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1173020013188 putative active site [active] 1173020013189 Double zinc ribbon; Region: DZR; pfam12773 1173020013190 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1173020013191 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173020013192 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173020013193 phosphopeptide binding site; other site 1173020013194 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173020013195 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173020013196 phosphopeptide binding site; other site 1173020013197 DNA polymerase III subunit beta; Validated; Region: PRK05643 1173020013198 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1173020013199 putative DNA binding surface [nucleotide binding]; other site 1173020013200 dimer interface [polypeptide binding]; other site 1173020013201 beta-clamp/clamp loader binding surface; other site 1173020013202 beta-clamp/translesion DNA polymerase binding surface; other site 1173020013203 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1173020013204 CPxP motif; other site 1173020013205 chaperone protein DnaJ; Provisional; Region: PRK14293 1173020013206 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173020013207 HSP70 interaction site [polypeptide binding]; other site 1173020013208 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1173020013209 substrate binding site [polypeptide binding]; other site 1173020013210 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1173020013211 Zn binding sites [ion binding]; other site 1173020013212 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1173020013213 dimer interface [polypeptide binding]; other site 1173020013214 molecular chaperone DnaK; Provisional; Region: PRK13411 1173020013215 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1173020013216 nucleotide binding site [chemical binding]; other site 1173020013217 NEF interaction site [polypeptide binding]; other site 1173020013218 SBD interface [polypeptide binding]; other site 1173020013219 GrpE; Region: GrpE; pfam01025 1173020013220 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1173020013221 dimer interface [polypeptide binding]; other site 1173020013222 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1173020013223 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1173020013224 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1173020013225 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1173020013226 Walker A motif; other site 1173020013227 ATP binding site [chemical binding]; other site 1173020013228 Walker B motif; other site 1173020013229 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1173020013230 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1173020013231 Walker A motif; other site 1173020013232 ATP binding site [chemical binding]; other site 1173020013233 Walker B motif; other site 1173020013234 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1173020013235 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1173020013236 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1173020013237 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1173020013238 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1173020013239 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 1173020013240 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1173020013241 homodecamer interface [polypeptide binding]; other site 1173020013242 GTP cyclohydrolase I; Provisional; Region: PLN03044 1173020013243 active site 1173020013244 putative catalytic site residues [active] 1173020013245 zinc binding site [ion binding]; other site 1173020013246 GTP-CH-I/GFRP interaction surface; other site 1173020013247 short chain dehydrogenase; Provisional; Region: PRK07454 1173020013248 classical (c) SDRs; Region: SDR_c; cd05233 1173020013249 NAD(P) binding site [chemical binding]; other site 1173020013250 active site 1173020013251 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1173020013252 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1173020013253 acyl-ACP reductase; Provisional; Region: PRK14982 1173020013254 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1173020013255 NAD(P) binding pocket [chemical binding]; other site 1173020013256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020013257 dimer interface [polypeptide binding]; other site 1173020013258 conserved gate region; other site 1173020013259 putative PBP binding loops; other site 1173020013260 ABC-ATPase subunit interface; other site 1173020013261 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1173020013262 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 1173020013263 glucokinase; Provisional; Region: glk; PRK00292 1173020013264 glucokinase, proteobacterial type; Region: glk; TIGR00749 1173020013265 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1173020013266 Clp amino terminal domain; Region: Clp_N; pfam02861 1173020013267 Clp amino terminal domain; Region: Clp_N; pfam02861 1173020013268 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020013269 Walker A motif; other site 1173020013270 ATP binding site [chemical binding]; other site 1173020013271 Walker B motif; other site 1173020013272 arginine finger; other site 1173020013273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020013274 Walker A motif; other site 1173020013275 ATP binding site [chemical binding]; other site 1173020013276 Walker B motif; other site 1173020013277 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1173020013278 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1173020013279 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1173020013280 feedback inhibition sensing region; other site 1173020013281 homohexameric interface [polypeptide binding]; other site 1173020013282 nucleotide binding site [chemical binding]; other site 1173020013283 N-acetyl-L-glutamate binding site [chemical binding]; other site 1173020013284 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173020013285 TPR motif; other site 1173020013286 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 1173020013287 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1173020013288 active site 1173020013289 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1173020013290 active site 1173020013291 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1173020013292 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 1173020013293 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1173020013294 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1173020013295 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 1173020013296 NAD binding site [chemical binding]; other site 1173020013297 homotetramer interface [polypeptide binding]; other site 1173020013298 homodimer interface [polypeptide binding]; other site 1173020013299 substrate binding site [chemical binding]; other site 1173020013300 active site 1173020013301 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1173020013302 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1173020013303 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173020013304 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1173020013305 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1173020013306 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1173020013307 M28 Zn-Peptidases; Region: M28_like_3; cd05644 1173020013308 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 1173020013309 active site 1173020013310 metal binding site [ion binding]; metal-binding site 1173020013311 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1173020013312 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1173020013313 substrate binding site; other site 1173020013314 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1173020013315 short chain dehydrogenase; Provisional; Region: PRK08219 1173020013316 classical (c) SDRs; Region: SDR_c; cd05233 1173020013317 NAD(P) binding site [chemical binding]; other site 1173020013318 active site 1173020013319 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1173020013320 Phosphate acyltransferases; Region: PlsC; smart00563 1173020013321 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173020013322 putative acyl-acceptor binding pocket; other site 1173020013323 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1173020013324 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1173020013325 Cl- selectivity filter; other site 1173020013326 Cl- binding residues [ion binding]; other site 1173020013327 pore gating glutamate residue; other site 1173020013328 dimer interface [polypeptide binding]; other site 1173020013329 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1173020013330 FOG: CBS domain [General function prediction only]; Region: COG0517 1173020013331 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in bacteria and archaea. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; Region: CBS_pair_EriC_assoc_bac_arch; cd04593 1173020013332 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1173020013333 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 1173020013334 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1173020013335 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1173020013336 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 1173020013337 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1173020013338 Secretin and TonB N terminus short domain; Region: STN; pfam07660 1173020013339 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1173020013340 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1173020013341 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1173020013342 IHF dimer interface [polypeptide binding]; other site 1173020013343 IHF - DNA interface [nucleotide binding]; other site 1173020013344 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1173020013345 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173020013346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020013347 homodimer interface [polypeptide binding]; other site 1173020013348 catalytic residue [active] 1173020013349 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 1173020013350 Predicted flavoprotein [General function prediction only]; Region: COG0431 1173020013351 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1173020013352 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1173020013353 Short C-terminal domain; Region: SHOCT; pfam09851 1173020013354 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 1173020013355 Calx-beta domain; Region: Calx-beta; cl02522 1173020013356 Calx-beta domain; Region: Calx-beta; cl02522 1173020013357 Calx-beta domain; Region: Calx-beta; cl02522 1173020013358 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 1173020013359 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1173020013360 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 1173020013361 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1173020013362 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1173020013363 putative ADP-binding pocket [chemical binding]; other site 1173020013364 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1173020013365 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020013366 putative ADP-binding pocket [chemical binding]; other site 1173020013367 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1173020013368 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1173020013369 motif II; other site 1173020013370 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173020013371 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1173020013372 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1173020013373 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1173020013374 Protein of unknown function DUF58; Region: DUF58; pfam01882 1173020013375 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1173020013376 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1173020013377 putative active site [active] 1173020013378 putative dimer interface [polypeptide binding]; other site 1173020013379 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173020013380 active site 1173020013381 geranylgeranyl reductase; Region: ChlP; TIGR02028 1173020013382 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173020013383 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1173020013384 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1173020013385 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1173020013386 FMN binding site [chemical binding]; other site 1173020013387 active site 1173020013388 catalytic residues [active] 1173020013389 substrate binding site [chemical binding]; other site 1173020013390 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 1173020013391 ADP-ribose binding site [chemical binding]; other site 1173020013392 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173020013393 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173020013394 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 1173020013395 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1173020013396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173020013397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173020013398 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1173020013399 active site 1173020013400 Int/Topo IB signature motif; other site 1173020013401 catalytic residues [active] 1173020013402 DNA binding site [nucleotide binding] 1173020013403 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1173020013404 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1173020013405 Di-iron ligands [ion binding]; other site 1173020013406 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173020013407 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173020013408 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1173020013409 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173020013410 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1173020013411 dimer interface [polypeptide binding]; other site 1173020013412 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1173020013413 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1173020013414 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1173020013415 active site 1173020013416 dimer interface [polypeptide binding]; other site 1173020013417 motif 1; other site 1173020013418 motif 2; other site 1173020013419 motif 3; other site 1173020013420 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1173020013421 anticodon binding site; other site 1173020013422 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1173020013423 PhoH-like protein; Region: PhoH; pfam02562 1173020013424 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173020013425 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173020013426 WHG domain; Region: WHG; pfam13305 1173020013427 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1173020013428 hydrophobic ligand binding site; other site 1173020013429 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 1173020013430 putative hexamer interface [polypeptide binding]; other site 1173020013431 putative hexagonal pore; other site 1173020013432 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 1173020013433 Hexamer interface [polypeptide binding]; other site 1173020013434 Hexagonal pore residue; other site 1173020013435 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173020013436 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020013437 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020013438 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020013439 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020013440 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020013441 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173020013442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020013443 active site 1173020013444 phosphorylation site [posttranslational modification] 1173020013445 intermolecular recognition site; other site 1173020013446 dimerization interface [polypeptide binding]; other site 1173020013447 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020013448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020013449 active site 1173020013450 phosphorylation site [posttranslational modification] 1173020013451 intermolecular recognition site; other site 1173020013452 dimerization interface [polypeptide binding]; other site 1173020013453 CheW-like domain; Region: CheW; pfam01584 1173020013454 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020013455 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020013456 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020013457 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020013458 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020013459 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020013460 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020013461 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020013462 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173020013463 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173020013464 dimer interface [polypeptide binding]; other site 1173020013465 putative CheW interface [polypeptide binding]; other site 1173020013466 CheW-like domain; Region: CheW; pfam01584 1173020013467 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1173020013468 transketolase; Region: PLN02790 1173020013469 TPP-binding site [chemical binding]; other site 1173020013470 dimer interface [polypeptide binding]; other site 1173020013471 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1173020013472 PYR/PP interface [polypeptide binding]; other site 1173020013473 dimer interface [polypeptide binding]; other site 1173020013474 TPP binding site [chemical binding]; other site 1173020013475 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1173020013476 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1173020013477 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1173020013478 putative substrate binding site [chemical binding]; other site 1173020013479 putative ATP binding site [chemical binding]; other site 1173020013480 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 1173020013481 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1173020013482 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173020013483 active site 1173020013484 CP12 domain; Region: CP12; pfam02672 1173020013485 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1173020013486 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1173020013487 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1173020013488 putative dimer interface [polypeptide binding]; other site 1173020013489 N-terminal domain interface [polypeptide binding]; other site 1173020013490 putative substrate binding pocket (H-site) [chemical binding]; other site 1173020013491 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1173020013492 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 1173020013493 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1173020013494 homodimer interface [polypeptide binding]; other site 1173020013495 NADP binding site [chemical binding]; other site 1173020013496 substrate binding site [chemical binding]; other site 1173020013497 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020013498 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1173020013499 putative ADP-binding pocket [chemical binding]; other site 1173020013500 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1173020013501 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1173020013502 metal binding site [ion binding]; metal-binding site 1173020013503 dimer interface [polypeptide binding]; other site 1173020013504 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1173020013505 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1173020013506 GTP-binding protein Der; Reviewed; Region: PRK00093 1173020013507 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1173020013508 G1 box; other site 1173020013509 GTP/Mg2+ binding site [chemical binding]; other site 1173020013510 Switch I region; other site 1173020013511 G2 box; other site 1173020013512 Switch II region; other site 1173020013513 G3 box; other site 1173020013514 G4 box; other site 1173020013515 G5 box; other site 1173020013516 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1173020013517 G1 box; other site 1173020013518 GTP/Mg2+ binding site [chemical binding]; other site 1173020013519 Switch I region; other site 1173020013520 G2 box; other site 1173020013521 G3 box; other site 1173020013522 Switch II region; other site 1173020013523 G4 box; other site 1173020013524 G5 box; other site 1173020013525 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1173020013526 anthranilate synthase component I-like protein; Validated; Region: PRK05940 1173020013527 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1173020013528 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1173020013529 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 1173020013530 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1173020013531 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1173020013532 catalytic residue [active] 1173020013533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1173020013534 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1173020013535 pyrroline-5-carboxylate reductase; Region: PLN02688 1173020013536 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1173020013537 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1173020013538 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1173020013539 substrate binding site; other site 1173020013540 dimer interface; other site 1173020013541 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1173020013542 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1173020013543 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1173020013544 putative NAD(P) binding site [chemical binding]; other site 1173020013545 putative active site [active] 1173020013546 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1173020013547 active site 1173020013548 catalytic triad [active] 1173020013549 30S ribosomal protein S1; Reviewed; Region: PRK07400 1173020013550 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1173020013551 RNA binding site [nucleotide binding]; other site 1173020013552 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1173020013553 RNA binding site [nucleotide binding]; other site 1173020013554 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1173020013555 RNA binding site [nucleotide binding]; other site 1173020013556 2TM domain; Region: 2TM; pfam13239 1173020013557 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 1173020013558 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1173020013559 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1173020013560 RF-1 domain; Region: RF-1; pfam00472 1173020013561 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1173020013562 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020013563 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020013564 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020013565 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 1173020013566 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173020013567 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173020013568 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173020013569 DNA binding residues [nucleotide binding] 1173020013570 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 1173020013571 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1173020013572 GSH binding site [chemical binding]; other site 1173020013573 catalytic residues [active] 1173020013574 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1173020013575 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1173020013576 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1173020013577 CAAX protease self-immunity; Region: Abi; pfam02517 1173020013578 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1173020013579 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1173020013580 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1173020013581 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 1173020013582 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173020013583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020013584 S-adenosylmethionine binding site [chemical binding]; other site 1173020013585 Predicted permease [General function prediction only]; Region: COG3329 1173020013586 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1173020013587 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1173020013588 putative dimer interface [polypeptide binding]; other site 1173020013589 putative anticodon binding site; other site 1173020013590 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1173020013591 homodimer interface [polypeptide binding]; other site 1173020013592 motif 1; other site 1173020013593 motif 2; other site 1173020013594 active site 1173020013595 motif 3; other site 1173020013596 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1173020013597 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1173020013598 homodimer interface [polypeptide binding]; other site 1173020013599 metal binding site [ion binding]; metal-binding site 1173020013600 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1173020013601 homodimer interface [polypeptide binding]; other site 1173020013602 active site 1173020013603 putative chemical substrate binding site [chemical binding]; other site 1173020013604 metal binding site [ion binding]; metal-binding site 1173020013605 NifU-like domain; Region: NifU; pfam01106 1173020013606 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1173020013607 active site 1173020013608 dimerization interface [polypeptide binding]; other site 1173020013609 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1173020013610 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1173020013611 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1173020013612 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1173020013613 phosphoglyceromutase; Provisional; Region: PRK05434 1173020013614 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1173020013615 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173020013616 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173020013617 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020013618 TPR motif; other site 1173020013619 binding surface 1173020013620 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173020013621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020013622 binding surface 1173020013623 TPR motif; other site 1173020013624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020013625 binding surface 1173020013626 TPR motif; other site 1173020013627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020013628 binding surface 1173020013629 TPR motif; other site 1173020013630 tRNAHis guanylyltransferase; Region: Thg1; pfam04446 1173020013631 Uncharacterized conserved protein [Function unknown]; Region: COG4021 1173020013632 Thg1 C terminal domain; Region: Thg1C; pfam14413 1173020013633 AAA domain; Region: AAA_33; pfam13671 1173020013634 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1173020013635 Transglycosylase; Region: Transgly; pfam00912 1173020013636 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1173020013637 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1173020013638 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020013639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020013640 active site 1173020013641 phosphorylation site [posttranslational modification] 1173020013642 intermolecular recognition site; other site 1173020013643 dimerization interface [polypeptide binding]; other site 1173020013644 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173020013645 putative binding surface; other site 1173020013646 active site 1173020013647 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1173020013648 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1173020013649 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1173020013650 ABC1 family; Region: ABC1; cl17513 1173020013651 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1173020013652 Leucine rich repeat; Region: LRR_8; pfam13855 1173020013653 Leucine-rich repeats; other site 1173020013654 Leucine rich repeat; Region: LRR_8; pfam13855 1173020013655 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 1173020013656 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1173020013657 active site 1173020013658 ATP binding site [chemical binding]; other site 1173020013659 substrate binding site [chemical binding]; other site 1173020013660 activation loop (A-loop); other site 1173020013661 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173020013662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020013663 active site 1173020013664 phosphorylation site [posttranslational modification] 1173020013665 intermolecular recognition site; other site 1173020013666 dimerization interface [polypeptide binding]; other site 1173020013667 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173020013668 dimerization interface [polypeptide binding]; other site 1173020013669 DNA binding residues [nucleotide binding] 1173020013670 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1173020013671 Histidine kinase; Region: HisKA_3; pfam07730 1173020013672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020013673 ATP binding site [chemical binding]; other site 1173020013674 Mg2+ binding site [ion binding]; other site 1173020013675 G-X-G motif; other site 1173020013676 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1173020013677 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1173020013678 Surface antigen; Region: Bac_surface_Ag; pfam01103 1173020013679 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1173020013680 active site 1173020013681 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 1173020013682 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1173020013683 ATP binding site [chemical binding]; other site 1173020013684 putative Mg++ binding site [ion binding]; other site 1173020013685 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1173020013686 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1173020013687 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020013688 putative active site [active] 1173020013689 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1173020013690 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1173020013691 Walker A/P-loop; other site 1173020013692 ATP binding site [chemical binding]; other site 1173020013693 Q-loop/lid; other site 1173020013694 ABC transporter signature motif; other site 1173020013695 Walker B; other site 1173020013696 D-loop; other site 1173020013697 H-loop/switch region; other site 1173020013698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020013699 H+ Antiporter protein; Region: 2A0121; TIGR00900 1173020013700 putative substrate translocation pore; other site 1173020013701 Recombination protein O N terminal; Region: RecO_N; pfam11967 1173020013702 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1173020013703 Recombination protein O C terminal; Region: RecO_C; pfam02565 1173020013704 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1173020013705 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1173020013706 [2Fe-2S] cluster binding site [ion binding]; other site 1173020013707 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1173020013708 hydrophobic ligand binding site; other site 1173020013709 Protein of unknown function (DUF760); Region: DUF760; pfam05542 1173020013710 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1173020013711 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 1173020013712 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1173020013713 RNB domain; Region: RNB; pfam00773 1173020013714 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1173020013715 ribosomal protein L33; Region: rpl33; CHL00104 1173020013716 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1173020013717 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1173020013718 c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177 1173020013719 ResB-like family; Region: ResB; pfam05140 1173020013720 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1173020013721 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1173020013722 putative active site [active] 1173020013723 hypothetical protein; Provisional; Region: PRK06185 1173020013724 hypothetical protein; Provisional; Region: PRK07236 1173020013725 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173020013726 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 1173020013727 Protein of unknown function (DUF565); Region: DUF565; pfam04483 1173020013728 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR4; cd08270 1173020013729 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1173020013730 putative NAD(P) binding site [chemical binding]; other site 1173020013731 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1173020013732 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1173020013733 inhibitor-cofactor binding pocket; inhibition site 1173020013734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020013735 catalytic residue [active] 1173020013736 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1173020013737 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173020013738 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020013739 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1173020013740 putative hydrophobic ligand binding site [chemical binding]; other site 1173020013741 SnoaL-like domain; Region: SnoaL_2; pfam12680 1173020013742 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173020013743 dimerization interface [polypeptide binding]; other site 1173020013744 putative DNA binding site [nucleotide binding]; other site 1173020013745 putative Zn2+ binding site [ion binding]; other site 1173020013746 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173020013747 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173020013748 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1173020013749 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1173020013750 putative NAD(P) binding site [chemical binding]; other site 1173020013751 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1173020013752 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1173020013753 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 1173020013754 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1173020013755 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020013756 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173020013757 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020013758 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1173020013759 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1173020013760 homodimer interface [polypeptide binding]; other site 1173020013761 active site 1173020013762 TDP-binding site; other site 1173020013763 acceptor substrate-binding pocket; other site 1173020013764 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173020013765 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173020013766 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1173020013767 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020013768 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 1173020013769 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 1173020013770 homodimer interface [polypeptide binding]; other site 1173020013771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020013772 catalytic residue [active] 1173020013773 Protein of unknown function DUF45; Region: DUF45; pfam01863 1173020013774 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1173020013775 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173020013776 Coenzyme A binding pocket [chemical binding]; other site 1173020013777 ribonuclease Z; Region: RNase_Z; TIGR02651 1173020013778 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1173020013779 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1173020013780 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 1173020013781 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1173020013782 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1173020013783 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1173020013784 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 1173020013785 dimerization interface [polypeptide binding]; other site 1173020013786 active site 1173020013787 metal binding site [ion binding]; metal-binding site 1173020013788 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1173020013789 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1173020013790 anti sigma factor interaction site; other site 1173020013791 regulatory phosphorylation site [posttranslational modification]; other site 1173020013792 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1173020013793 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1173020013794 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1173020013795 catalytic site [active] 1173020013796 subunit interface [polypeptide binding]; other site 1173020013797 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1173020013798 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1173020013799 Catalytic site [active] 1173020013800 KTSC domain; Region: KTSC; pfam13619 1173020013801 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1173020013802 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1173020013803 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1173020013804 Catalytic site [active] 1173020013805 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 1173020013806 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1173020013807 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1173020013808 Bacterial SH3 domain; Region: SH3_3; pfam08239 1173020013809 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1173020013810 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1173020013811 active site 1173020013812 metal binding site [ion binding]; metal-binding site 1173020013813 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1173020013814 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1173020013815 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020013816 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 1173020013817 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173020013818 Ligand Binding Site [chemical binding]; other site 1173020013819 chaperone protein DnaJ; Provisional; Region: PRK14299 1173020013820 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173020013821 HSP70 interaction site [polypeptide binding]; other site 1173020013822 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1173020013823 substrate binding site [polypeptide binding]; other site 1173020013824 dimer interface [polypeptide binding]; other site 1173020013825 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1173020013826 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1173020013827 DNA binding residues [nucleotide binding] 1173020013828 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1173020013829 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1173020013830 30S subunit binding site; other site 1173020013831 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1173020013832 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1173020013833 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020013834 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173020013835 putative active site [active] 1173020013836 heme pocket [chemical binding]; other site 1173020013837 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173020013838 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020013839 putative active site [active] 1173020013840 heme pocket [chemical binding]; other site 1173020013841 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020013842 putative active site [active] 1173020013843 heme pocket [chemical binding]; other site 1173020013844 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1173020013845 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020013846 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020013847 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1173020013848 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1173020013849 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1173020013850 E3 interaction surface; other site 1173020013851 lipoyl attachment site [posttranslational modification]; other site 1173020013852 e3 binding domain; Region: E3_binding; pfam02817 1173020013853 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1173020013854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020013855 Walker A motif; other site 1173020013856 ATP binding site [chemical binding]; other site 1173020013857 Walker B motif; other site 1173020013858 arginine finger; other site 1173020013859 Peptidase family M41; Region: Peptidase_M41; pfam01434 1173020013860 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1173020013861 Sporulation and spore germination; Region: Germane; pfam10646 1173020013862 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1173020013863 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1173020013864 putative dimer interface [polypeptide binding]; other site 1173020013865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173020013866 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173020013867 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173020013868 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1173020013869 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1173020013870 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173020013871 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1173020013872 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1173020013873 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1173020013874 GUN4-like; Region: GUN4; pfam05419 1173020013875 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 1173020013876 MltA specific insert domain; Region: MltA; pfam03562 1173020013877 3D domain; Region: 3D; pfam06725 1173020013878 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1173020013879 Fe-S cluster binding site [ion binding]; other site 1173020013880 active site 1173020013881 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1173020013882 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1173020013883 nucleotide binding site [chemical binding]; other site 1173020013884 putative addiction module antidote; Region: doc_partner; TIGR02609 1173020013885 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1173020013886 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1173020013887 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1173020013888 putative active site [active] 1173020013889 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1173020013890 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173020013891 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1173020013892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173020013893 dimer interface [polypeptide binding]; other site 1173020013894 conserved gate region; other site 1173020013895 ABC-ATPase subunit interface; other site 1173020013896 homoserine dehydrogenase; Provisional; Region: PRK06349 1173020013897 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1173020013898 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1173020013899 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1173020013900 Predicted membrane protein [Function unknown]; Region: COG2119 1173020013901 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1173020013902 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1173020013903 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020013904 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020013905 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1173020013906 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1173020013907 active site 1173020013908 Substrate binding site; other site 1173020013909 Mg++ binding site; other site 1173020013910 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1173020013911 putative trimer interface [polypeptide binding]; other site 1173020013912 putative CoA binding site [chemical binding]; other site 1173020013913 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1173020013914 GTPase Era; Reviewed; Region: era; PRK00089 1173020013915 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1173020013916 G1 box; other site 1173020013917 GTP/Mg2+ binding site [chemical binding]; other site 1173020013918 Switch I region; other site 1173020013919 G2 box; other site 1173020013920 Switch II region; other site 1173020013921 G3 box; other site 1173020013922 G4 box; other site 1173020013923 G5 box; other site 1173020013924 KH domain; Region: KH_2; pfam07650 1173020013925 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173020013926 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1173020013927 putative active site [active] 1173020013928 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1173020013929 Predicted transcriptional regulators [Transcription]; Region: COG1695 1173020013930 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 1173020013931 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1173020013932 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1173020013933 subunit interactions [polypeptide binding]; other site 1173020013934 active site 1173020013935 flap region; other site 1173020013936 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173020013937 salt bridge; other site 1173020013938 non-specific DNA binding site [nucleotide binding]; other site 1173020013939 sequence-specific DNA binding site [nucleotide binding]; other site 1173020013940 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 1173020013941 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 1173020013942 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1173020013943 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1173020013944 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1173020013945 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1173020013946 catalytic residue [active] 1173020013947 putative FPP diphosphate binding site; other site 1173020013948 putative FPP binding hydrophobic cleft; other site 1173020013949 dimer interface [polypeptide binding]; other site 1173020013950 putative IPP diphosphate binding site; other site 1173020013951 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173020013952 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1173020013953 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173020013954 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173020013955 active site 1173020013956 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173020013957 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173020013958 active site 1173020013959 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020013960 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1173020013961 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1173020013962 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173020013963 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173020013964 active site 1173020013965 hypothetical protein; Provisional; Region: PRK07208 1173020013966 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173020013967 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1173020013968 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 1173020013969 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173020013970 active site 1173020013971 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1173020013972 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1173020013973 putative substrate binding site [chemical binding]; other site 1173020013974 putative ATP binding site [chemical binding]; other site 1173020013975 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1173020013976 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1173020013977 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173020013978 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1173020013979 active site 1173020013980 metal binding site [ion binding]; metal-binding site 1173020013981 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1173020013982 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1173020013983 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1173020013984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020013985 S-adenosylmethionine binding site [chemical binding]; other site 1173020013986 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 1173020013987 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173020013988 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1173020013989 putative acyl-acceptor binding pocket; other site 1173020013990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1173020013991 Predicted kinase [General function prediction only]; Region: COG0645 1173020013992 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1173020013993 ATP-binding site [chemical binding]; other site 1173020013994 Gluconate-6-phosphate binding site [chemical binding]; other site 1173020013995 AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478 1173020013996 [2Fe-2S] cluster binding site [ion binding]; other site 1173020013997 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1173020013998 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173020013999 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173020014000 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 1173020014001 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1173020014002 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1173020014003 putative di-iron ligands [ion binding]; other site 1173020014004 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 1173020014005 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 1173020014006 putative NAD(P) binding site [chemical binding]; other site 1173020014007 active site 1173020014008 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1173020014009 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1173020014010 GTP/Mg2+ binding site [chemical binding]; other site 1173020014011 G4 box; other site 1173020014012 G5 box; other site 1173020014013 G1 box; other site 1173020014014 Switch I region; other site 1173020014015 G2 box; other site 1173020014016 G3 box; other site 1173020014017 Switch II region; other site 1173020014018 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173020014019 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173020014020 Probable transposase; Region: OrfB_IS605; pfam01385 1173020014021 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173020014022 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020014023 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173020014024 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 1173020014025 PIN domain; Region: PIN_3; cl17397 1173020014026 GAF domain; Region: GAF; cl17456 1173020014027 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173020014028 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173020014029 DNA binding residues [nucleotide binding] 1173020014030 dimerization interface [polypeptide binding]; other site 1173020014031 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1173020014032 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1173020014033 active site residue [active] 1173020014034 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1173020014035 active site residue [active] 1173020014036 2TM domain; Region: 2TM; pfam13239 1173020014037 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1173020014038 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 1173020014039 putative NAD(P) binding site [chemical binding]; other site 1173020014040 catalytic Zn binding site [ion binding]; other site 1173020014041 Domain of unknown function (DUF1817); Region: DUF1817; pfam08847 1173020014042 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173020014043 phosphopeptide binding site; other site 1173020014044 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173020014045 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020014046 active site 1173020014047 ATP binding site [chemical binding]; other site 1173020014048 substrate binding site [chemical binding]; other site 1173020014049 activation loop (A-loop); other site 1173020014050 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 1173020014051 BolA-like protein; Region: BolA; pfam01722 1173020014052 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1173020014053 putative GSH binding site [chemical binding]; other site 1173020014054 catalytic residues [active] 1173020014055 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020014056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020014057 active site 1173020014058 phosphorylation site [posttranslational modification] 1173020014059 intermolecular recognition site; other site 1173020014060 dimerization interface [polypeptide binding]; other site 1173020014061 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020014062 DNA binding site [nucleotide binding] 1173020014063 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1173020014064 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1173020014065 Zn2+ binding site [ion binding]; other site 1173020014066 Mg2+ binding site [ion binding]; other site 1173020014067 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1173020014068 synthetase active site [active] 1173020014069 NTP binding site [chemical binding]; other site 1173020014070 metal binding site [ion binding]; metal-binding site 1173020014071 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1173020014072 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1173020014073 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1173020014074 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1173020014075 Bacterial SH3 domain; Region: SH3_3; pfam08239 1173020014076 O-succinylbenzoate synthase; Provisional; Region: PRK02714 1173020014077 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1173020014078 active site 1173020014079 Uncharacterized conserved protein [Function unknown]; Region: COG1565 1173020014080 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1173020014081 EamA-like transporter family; Region: EamA; pfam00892 1173020014082 EamA-like transporter family; Region: EamA; pfam00892 1173020014083 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 1173020014084 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173020014085 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1173020014086 putative dimerization interface [polypeptide binding]; other site 1173020014087 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173020014088 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1173020014089 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1173020014090 transmembrane helices; other site 1173020014091 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173020014092 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173020014093 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1173020014094 Walker A/P-loop; other site 1173020014095 ATP binding site [chemical binding]; other site 1173020014096 Q-loop/lid; other site 1173020014097 ABC transporter signature motif; other site 1173020014098 Walker B; other site 1173020014099 D-loop; other site 1173020014100 H-loop/switch region; other site 1173020014101 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1173020014102 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1173020014103 dimer interface [polypeptide binding]; other site 1173020014104 ssDNA binding site [nucleotide binding]; other site 1173020014105 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1173020014106 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173020014107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020014108 putative substrate translocation pore; other site 1173020014109 AAA ATPase domain; Region: AAA_16; pfam13191 1173020014110 NACHT domain; Region: NACHT; pfam05729 1173020014111 Walker A motif; other site 1173020014112 ATP binding site [chemical binding]; other site 1173020014113 Walker B motif; other site 1173020014114 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020014115 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020014116 structural tetrad; other site 1173020014117 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173020014118 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173020014119 structural tetrad; other site 1173020014120 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1173020014121 ligand-binding site [chemical binding]; other site 1173020014122 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1173020014123 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1173020014124 active site 1173020014125 catalytic residues [active] 1173020014126 metal binding site [ion binding]; metal-binding site 1173020014127 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1173020014128 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173020014129 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173020014130 catalytic loop [active] 1173020014131 iron binding site [ion binding]; other site 1173020014132 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1173020014133 NADPH bind site [chemical binding]; other site 1173020014134 putative FMN binding site [chemical binding]; other site 1173020014135 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1173020014136 putative FMN binding site [chemical binding]; other site 1173020014137 NADPH bind site [chemical binding]; other site 1173020014138 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1173020014139 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1173020014140 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1173020014141 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1173020014142 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1173020014143 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1173020014144 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1173020014145 dimer interface [polypeptide binding]; other site 1173020014146 anticodon binding site; other site 1173020014147 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1173020014148 homodimer interface [polypeptide binding]; other site 1173020014149 motif 1; other site 1173020014150 active site 1173020014151 motif 2; other site 1173020014152 GAD domain; Region: GAD; pfam02938 1173020014153 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1173020014154 active site 1173020014155 motif 3; other site 1173020014156 CsbD-like; Region: CsbD; pfam05532 1173020014157 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 1173020014158 Fungal symportin 1 (syo1) and similar proteins; Region: Syo1_like; cd13394 1173020014159 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 1173020014160 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 1173020014161 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1173020014162 ABC1 family; Region: ABC1; cl17513 1173020014163 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020014164 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020014165 dimer interface [polypeptide binding]; other site 1173020014166 phosphorylation site [posttranslational modification] 1173020014167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020014168 ATP binding site [chemical binding]; other site 1173020014169 Mg2+ binding site [ion binding]; other site 1173020014170 G-X-G motif; other site 1173020014171 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1173020014172 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1173020014173 DXD motif; other site 1173020014174 Predicted transcriptional regulators [Transcription]; Region: COG1725 1173020014175 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1173020014176 DNA-binding site [nucleotide binding]; DNA binding site 1173020014177 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1173020014178 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1173020014179 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1173020014180 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173020014181 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020014182 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1173020014183 active site 1173020014184 multimer interface [polypeptide binding]; other site 1173020014185 hypothetical protein; Provisional; Region: PRK04323 1173020014186 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1173020014187 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1173020014188 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1173020014189 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 1173020014190 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1173020014191 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1173020014192 active site 1173020014193 substrate binding site [chemical binding]; other site 1173020014194 cosubstrate binding site; other site 1173020014195 catalytic site [active] 1173020014196 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1173020014197 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173020014198 hypothetical protein; Validated; Region: PRK07413 1173020014199 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1173020014200 Walker A motif; other site 1173020014201 homodimer interface [polypeptide binding]; other site 1173020014202 ATP binding site [chemical binding]; other site 1173020014203 hydroxycobalamin binding site [chemical binding]; other site 1173020014204 Walker B motif; other site 1173020014205 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 1173020014206 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1173020014207 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173020014208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173020014209 homodimer interface [polypeptide binding]; other site 1173020014210 catalytic residue [active] 1173020014211 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1173020014212 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020014213 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020014214 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020014215 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020014216 putative active site [active] 1173020014217 response regulator FixJ; Provisional; Region: fixJ; PRK09390 1173020014218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020014219 active site 1173020014220 phosphorylation site [posttranslational modification] 1173020014221 intermolecular recognition site; other site 1173020014222 dimerization interface [polypeptide binding]; other site 1173020014223 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173020014224 DNA binding residues [nucleotide binding] 1173020014225 dimerization interface [polypeptide binding]; other site 1173020014226 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173020014227 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173020014228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020014229 Walker A/P-loop; other site 1173020014230 ATP binding site [chemical binding]; other site 1173020014231 Q-loop/lid; other site 1173020014232 ABC transporter signature motif; other site 1173020014233 Walker B; other site 1173020014234 D-loop; other site 1173020014235 H-loop/switch region; other site 1173020014236 ribosomal protein L9; Region: L9; TIGR00158 1173020014237 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1173020014238 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1173020014239 replicative DNA helicase; Region: DnaB; TIGR00665 1173020014240 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1173020014241 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1173020014242 Walker A motif; other site 1173020014243 ATP binding site [chemical binding]; other site 1173020014244 Walker B motif; other site 1173020014245 DNA binding loops [nucleotide binding] 1173020014246 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1173020014247 dihydropteroate synthase; Region: DHPS; TIGR01496 1173020014248 substrate binding pocket [chemical binding]; other site 1173020014249 dimer interface [polypeptide binding]; other site 1173020014250 inhibitor binding site; inhibition site 1173020014251 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 1173020014252 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1173020014253 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1173020014254 active site 1173020014255 Riboflavin kinase; Region: Flavokinase; pfam01687 1173020014256 Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425 1173020014257 Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425 1173020014258 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1173020014259 active site 1173020014260 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1173020014261 Double zinc ribbon; Region: DZR; pfam12773 1173020014262 Protein kinase domain; Region: Pkinase; pfam00069 1173020014263 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173020014264 active site 1173020014265 ATP binding site [chemical binding]; other site 1173020014266 substrate binding site [chemical binding]; other site 1173020014267 activation loop (A-loop); other site 1173020014268 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1173020014269 RNA/DNA hybrid binding site [nucleotide binding]; other site 1173020014270 active site 1173020014271 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1173020014272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020014273 Walker A motif; other site 1173020014274 ATP binding site [chemical binding]; other site 1173020014275 Walker B motif; other site 1173020014276 arginine finger; other site 1173020014277 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1173020014278 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1173020014279 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1173020014280 Walker A/P-loop; other site 1173020014281 ATP binding site [chemical binding]; other site 1173020014282 Q-loop/lid; other site 1173020014283 ABC transporter signature motif; other site 1173020014284 Walker B; other site 1173020014285 D-loop; other site 1173020014286 H-loop/switch region; other site 1173020014287 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 1173020014288 cobalt transport protein CbiN; Provisional; Region: PRK02898 1173020014289 cobalt transport protein CbiM; Validated; Region: PRK08319 1173020014290 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1173020014291 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020014292 binding surface 1173020014293 TPR motif; other site 1173020014294 TPR repeat; Region: TPR_11; pfam13414 1173020014295 TPR repeat; Region: TPR_11; pfam13414 1173020014296 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173020014297 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1173020014298 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1173020014299 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173020014300 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173020014301 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173020014302 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173020014303 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173020014304 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173020014305 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173020014306 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 1173020014307 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 1173020014308 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1173020014309 hypothetical protein; Validated; Region: PRK00029 1173020014310 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 1173020014311 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1173020014312 NADP binding site [chemical binding]; other site 1173020014313 homodimer interface [polypeptide binding]; other site 1173020014314 active site 1173020014315 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 1173020014316 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 1173020014317 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1173020014318 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1173020014319 PLD-like domain; Region: PLDc_2; pfam13091 1173020014320 putative active site [active] 1173020014321 catalytic site [active] 1173020014322 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 1173020014323 putative C-terminal domain interface [polypeptide binding]; other site 1173020014324 putative GSH binding site [chemical binding]; other site 1173020014325 putative dimer interface [polypeptide binding]; other site 1173020014326 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 1173020014327 putative N-terminal domain interface [polypeptide binding]; other site 1173020014328 hypothetical protein; Provisional; Region: PRK07394 1173020014329 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1173020014330 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1173020014331 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173020014332 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1173020014333 dimerization interface [polypeptide binding]; other site 1173020014334 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1173020014335 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1173020014336 active site 1173020014337 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1173020014338 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1173020014339 MOSC domain; Region: MOSC; pfam03473 1173020014340 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1173020014341 thiamine monophosphate kinase; Provisional; Region: PRK05731 1173020014342 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1173020014343 ATP binding site [chemical binding]; other site 1173020014344 dimerization interface [polypeptide binding]; other site 1173020014345 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1173020014346 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1173020014347 putative active site [active] 1173020014348 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1173020014349 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1173020014350 tRNA; other site 1173020014351 putative tRNA binding site [nucleotide binding]; other site 1173020014352 putative NADP binding site [chemical binding]; other site 1173020014353 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1173020014354 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1173020014355 YcfA-like protein; Region: YcfA; pfam07927 1173020014356 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1173020014357 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1173020014358 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1173020014359 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173020014360 ATP binding site [chemical binding]; other site 1173020014361 putative Mg++ binding site [ion binding]; other site 1173020014362 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173020014363 nucleotide binding region [chemical binding]; other site 1173020014364 ATP-binding site [chemical binding]; other site 1173020014365 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1173020014366 HRDC domain; Region: HRDC; pfam00570 1173020014367 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173020014368 active site 1173020014369 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1173020014370 active site 1173020014371 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1173020014372 Ligand Binding Site [chemical binding]; other site 1173020014373 Molecular Tunnel; other site 1173020014374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1173020014375 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173020014376 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173020014377 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1173020014378 active site 1173020014379 metal binding site [ion binding]; metal-binding site 1173020014380 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1173020014381 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1173020014382 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1173020014383 catalytic residue [active] 1173020014384 Predicted membrane protein [Function unknown]; Region: COG4803 1173020014385 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173020014386 Ligand Binding Site [chemical binding]; other site 1173020014387 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 1173020014388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020014389 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1173020014390 putative substrate translocation pore; other site 1173020014391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020014392 H+ Antiporter protein; Region: 2A0121; TIGR00900 1173020014393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020014394 putative substrate translocation pore; other site 1173020014395 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1173020014396 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1173020014397 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173020014398 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1173020014399 MarR family; Region: MarR; pfam01047 1173020014400 MarR family; Region: MarR_2; cl17246 1173020014401 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 1173020014402 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 1173020014403 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1173020014404 substrate binding site [chemical binding]; other site 1173020014405 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173020014406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020014407 putative substrate translocation pore; other site 1173020014408 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173020014409 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1173020014410 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1173020014411 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1173020014412 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 1173020014413 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 1173020014414 putative phosphoketolase; Provisional; Region: PRK05261 1173020014415 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1173020014416 TPP-binding site; other site 1173020014417 XFP C-terminal domain; Region: XFP_C; pfam09363 1173020014418 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173020014419 catalytic residues [active] 1173020014420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 1173020014421 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1173020014422 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 1173020014423 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 1173020014424 Repair protein; Region: Repair_PSII; pfam04536 1173020014425 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 1173020014426 substrate binding site [chemical binding]; other site 1173020014427 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1173020014428 ATP binding site [chemical binding]; other site 1173020014429 interchain domain interface [polypeptide binding]; other site 1173020014430 intrachain domain interface; other site 1173020014431 Qi binding site; other site 1173020014432 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1173020014433 Qo binding site; other site 1173020014434 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1173020014435 interchain domain interface [polypeptide binding]; other site 1173020014436 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1173020014437 heme bL binding site [chemical binding]; other site 1173020014438 intrachain domain interface; other site 1173020014439 heme bH binding site [chemical binding]; other site 1173020014440 Qo binding site; other site 1173020014441 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1173020014442 Amidase; Region: Amidase; pfam01425 1173020014443 AAA domain; Region: AAA_17; pfam13207 1173020014444 putative anti-sigmaE protein; Provisional; Region: PRK13920 1173020014445 RNA polymerase sigma factor; Provisional; Region: PRK12519 1173020014446 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173020014447 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173020014448 DNA binding residues [nucleotide binding] 1173020014449 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 1173020014450 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173020014451 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173020014452 active site 1173020014453 metal binding site [ion binding]; metal-binding site 1173020014454 She9 / Mdm33 family; Region: She9_MDM33; pfam05546 1173020014455 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173020014456 Ligand Binding Site [chemical binding]; other site 1173020014457 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020014458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020014459 active site 1173020014460 phosphorylation site [posttranslational modification] 1173020014461 intermolecular recognition site; other site 1173020014462 dimerization interface [polypeptide binding]; other site 1173020014463 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020014464 DNA binding site [nucleotide binding] 1173020014465 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020014466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020014467 active site 1173020014468 phosphorylation site [posttranslational modification] 1173020014469 intermolecular recognition site; other site 1173020014470 dimerization interface [polypeptide binding]; other site 1173020014471 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 1173020014472 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173020014473 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1173020014474 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1173020014475 N terminal extension of bacteriophage endosialidase; Region: End_N_terminal; pfam12218 1173020014476 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173020014477 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020014478 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173020014479 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020014480 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 1173020014481 putative ADP-binding pocket [chemical binding]; other site 1173020014482 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020014483 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 1173020014484 putative active site [active] 1173020014485 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020014486 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 1173020014487 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173020014488 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020014489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1173020014490 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020014491 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1173020014492 putative ADP-binding pocket [chemical binding]; other site 1173020014493 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173020014494 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020014495 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1173020014496 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173020014497 active site 1173020014498 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1173020014499 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173020014500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020014501 S-adenosylmethionine binding site [chemical binding]; other site 1173020014502 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020014503 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1173020014504 putative ADP-binding pocket [chemical binding]; other site 1173020014505 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020014506 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173020014507 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173020014508 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 1173020014509 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173020014510 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020014511 Walker A/P-loop; other site 1173020014512 ATP binding site [chemical binding]; other site 1173020014513 Q-loop/lid; other site 1173020014514 ABC transporter signature motif; other site 1173020014515 Walker B; other site 1173020014516 D-loop; other site 1173020014517 H-loop/switch region; other site 1173020014518 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1173020014519 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1173020014520 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020014521 binding surface 1173020014522 TPR motif; other site 1173020014523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020014524 binding surface 1173020014525 TPR motif; other site 1173020014526 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 1173020014527 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 1173020014528 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 1173020014529 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1173020014530 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1173020014531 ParA-like protein; Provisional; Region: PHA02518 1173020014532 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173020014533 P-loop; other site 1173020014534 Magnesium ion binding site [ion binding]; other site 1173020014535 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 1173020014536 Origin of replication binding protein; Region: Herpes_ori_bp; pfam02399 1173020014537 DNA endonuclease related to intein-encoded endonucleases [DNA replication, recombination, and repair]; Region: COG3780 1173020014538 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 1173020014539 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1173020014540 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1173020014541 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1173020014542 active site 1173020014543 ATP binding site [chemical binding]; other site 1173020014544 substrate binding site [chemical binding]; other site 1173020014545 activation loop (A-loop); other site 1173020014546 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1173020014547 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1173020014548 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1173020014549 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1173020014550 catalytic residues [active] 1173020014551 catalytic nucleophile [active] 1173020014552 Presynaptic Site I dimer interface [polypeptide binding]; other site 1173020014553 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1173020014554 Synaptic Flat tetramer interface [polypeptide binding]; other site 1173020014555 Synaptic Site I dimer interface [polypeptide binding]; other site 1173020014556 DNA binding site [nucleotide binding] 1173020014557 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1173020014558 metal ion-dependent adhesion site (MIDAS); other site 1173020014559 Protein phosphatase 2C; Region: PP2C_2; pfam13672 1173020014560 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 1173020014561 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1173020014562 substrate binding site [chemical binding]; other site 1173020014563 activation loop (A-loop); other site 1173020014564 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020014565 TPR repeat; Region: TPR_11; pfam13414 1173020014566 binding surface 1173020014567 TPR motif; other site 1173020014568 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020014569 binding surface 1173020014570 TPR motif; other site 1173020014571 TPR repeat; Region: TPR_11; pfam13414 1173020014572 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173020014573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020014574 binding surface 1173020014575 TPR motif; other site 1173020014576 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020014577 binding surface 1173020014578 TPR motif; other site 1173020014579 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020014580 binding surface 1173020014581 TPR motif; other site 1173020014582 TPR repeat; Region: TPR_11; pfam13414 1173020014583 TPR repeat; Region: TPR_11; pfam13414 1173020014584 CHAT domain; Region: CHAT; pfam12770 1173020014585 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 1173020014586 FHA domain; Region: FHA; pfam00498 1173020014587 phosphopeptide binding site; other site 1173020014588 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1173020014589 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173020014590 Walker A/P-loop; other site 1173020014591 ATP binding site [chemical binding]; other site 1173020014592 Q-loop/lid; other site 1173020014593 ABC transporter signature motif; other site 1173020014594 Walker B; other site 1173020014595 D-loop; other site 1173020014596 H-loop/switch region; other site 1173020014597 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1173020014598 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1173020014599 TrwC relaxase; Region: TrwC; pfam08751 1173020014600 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1173020014601 AAA domain; Region: AAA_30; pfam13604 1173020014602 Family description; Region: UvrD_C_2; pfam13538 1173020014603 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1173020014604 nucleotide binding site [chemical binding]; other site 1173020014605 Domain of unknown function (DUF932); Region: DUF932; cl12129 1173020014606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020014607 S-adenosylmethionine binding site [chemical binding]; other site 1173020014608 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1173020014609 generic binding surface II; other site 1173020014610 generic binding surface I; other site 1173020014611 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1173020014612 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173020014613 ATP binding site [chemical binding]; other site 1173020014614 putative Mg++ binding site [ion binding]; other site 1173020014615 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173020014616 nucleotide binding region [chemical binding]; other site 1173020014617 ATP-binding site [chemical binding]; other site 1173020014618 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1173020014619 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 1173020014620 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173020014621 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020014622 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173020014623 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1173020014624 Predicted membrane protein [Function unknown]; Region: COG2733 1173020014625 oxidoreductase/ferric-chelate reductase; Region: PLN02844 1173020014626 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1173020014627 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173020014628 ATP binding site [chemical binding]; other site 1173020014629 putative Mg++ binding site [ion binding]; other site 1173020014630 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173020014631 ATP-binding site [chemical binding]; other site 1173020014632 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1173020014633 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1173020014634 putative active site [active] 1173020014635 TPR repeat; Region: TPR_11; pfam13414 1173020014636 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020014637 binding surface 1173020014638 TPR motif; other site 1173020014639 TPR repeat; Region: TPR_11; pfam13414 1173020014640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020014641 binding surface 1173020014642 TPR motif; other site 1173020014643 TPR repeat; Region: TPR_11; pfam13414 1173020014644 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1173020014645 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020014646 active site 1173020014647 DNA binding site [nucleotide binding] 1173020014648 Int/Topo IB signature motif; other site 1173020014649 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1173020014650 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020014651 active site 1173020014652 DNA binding site [nucleotide binding] 1173020014653 Int/Topo IB signature motif; other site 1173020014654 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1173020014655 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1173020014656 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1173020014657 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020014658 active site 1173020014659 DNA binding site [nucleotide binding] 1173020014660 Int/Topo IB signature motif; other site 1173020014661 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1173020014662 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173020014663 non-specific DNA binding site [nucleotide binding]; other site 1173020014664 salt bridge; other site 1173020014665 sequence-specific DNA binding site [nucleotide binding]; other site 1173020014666 Double zinc ribbon; Region: DZR; pfam12773 1173020014667 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1173020014668 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020014669 active site 1173020014670 Int/Topo IB signature motif; other site 1173020014671 DNA binding site [nucleotide binding] 1173020014672 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1173020014673 active site 1173020014674 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1173020014675 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 1173020014676 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1173020014677 TIGR02594 family protein; Region: TIGR02594 1173020014678 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173020014679 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1173020014680 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173020014681 non-specific DNA binding site [nucleotide binding]; other site 1173020014682 salt bridge; other site 1173020014683 sequence-specific DNA binding site [nucleotide binding]; other site 1173020014684 Domain of unknown function (DUF955); Region: DUF955; cl01076 1173020014685 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020014686 dimer interface [polypeptide binding]; other site 1173020014687 phosphorylation site [posttranslational modification] 1173020014688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020014689 ATP binding site [chemical binding]; other site 1173020014690 Mg2+ binding site [ion binding]; other site 1173020014691 G-X-G motif; other site 1173020014692 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020014693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020014694 active site 1173020014695 phosphorylation site [posttranslational modification] 1173020014696 intermolecular recognition site; other site 1173020014697 dimerization interface [polypeptide binding]; other site 1173020014698 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020014699 DNA binding site [nucleotide binding] 1173020014700 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1173020014701 Outer membrane efflux protein; Region: OEP; pfam02321 1173020014702 Outer membrane efflux protein; Region: OEP; pfam02321 1173020014703 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1173020014704 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1173020014705 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1173020014706 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173020014707 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1173020014708 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1173020014709 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 1173020014710 Beta-lactamase; Region: Beta-lactamase; cl17358 1173020014711 Zn(II)-responsive transcriptional regulator; Region: ZntR; TIGR02043 1173020014712 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1173020014713 DNA binding residues [nucleotide binding] 1173020014714 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1173020014715 dimerization interface [polypeptide binding]; other site 1173020014716 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1173020014717 flavodoxin FldA; Validated; Region: PRK09267 1173020014718 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1173020014719 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1173020014720 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1173020014721 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1173020014722 Predicted membrane protein [Function unknown]; Region: COG4803 1173020014723 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1173020014724 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1173020014725 metal-binding site [ion binding] 1173020014726 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173020014727 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173020014728 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1173020014729 Cation efflux family; Region: Cation_efflux; cl00316 1173020014730 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173020014731 AAA domain; Region: AAA_21; pfam13304 1173020014732 Walker A/P-loop; other site 1173020014733 ATP binding site [chemical binding]; other site 1173020014734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020014735 H+ Antiporter protein; Region: 2A0121; TIGR00900 1173020014736 putative substrate translocation pore; other site 1173020014737 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1173020014738 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1173020014739 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1173020014740 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1173020014741 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1173020014742 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1173020014743 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173020014744 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173020014745 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1173020014746 Walker A/P-loop; other site 1173020014747 ATP binding site [chemical binding]; other site 1173020014748 Q-loop/lid; other site 1173020014749 ABC transporter signature motif; other site 1173020014750 Walker B; other site 1173020014751 D-loop; other site 1173020014752 H-loop/switch region; other site 1173020014753 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173020014754 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1173020014755 Walker A/P-loop; other site 1173020014756 ATP binding site [chemical binding]; other site 1173020014757 Q-loop/lid; other site 1173020014758 ABC transporter signature motif; other site 1173020014759 Walker B; other site 1173020014760 D-loop; other site 1173020014761 H-loop/switch region; other site 1173020014762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020014763 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173020014764 putative substrate translocation pore; other site 1173020014765 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173020014766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173020014767 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1173020014768 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1173020014769 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1173020014770 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1173020014771 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1173020014772 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1173020014773 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020014774 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1173020014775 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1173020014776 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173020014777 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1173020014778 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173020014779 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1173020014780 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1173020014781 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1173020014782 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173020014783 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1173020014784 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173020014785 motif II; other site 1173020014786 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1173020014787 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1173020014788 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 1173020014789 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 1173020014790 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1173020014791 putative phosphoketolase; Provisional; Region: PRK05261 1173020014792 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1173020014793 TPP-binding site; other site 1173020014794 XFP C-terminal domain; Region: XFP_C; pfam09363 1173020014795 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1173020014796 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 1173020014797 active site 1173020014798 intersubunit interface [polypeptide binding]; other site 1173020014799 catalytic residue [active] 1173020014800 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 1173020014801 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1173020014802 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1173020014803 active site 1173020014804 catalytic site [active] 1173020014805 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1173020014806 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1173020014807 Protein of unknown function (DUF2810); Region: DUF2810; cl08159 1173020014808 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1173020014809 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1173020014810 metal-binding site [ion binding] 1173020014811 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1173020014812 dimerization interface [polypeptide binding]; other site 1173020014813 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1173020014814 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173020014815 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1173020014816 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020014817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020014818 active site 1173020014819 phosphorylation site [posttranslational modification] 1173020014820 intermolecular recognition site; other site 1173020014821 dimerization interface [polypeptide binding]; other site 1173020014822 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020014823 DNA binding site [nucleotide binding] 1173020014824 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020014825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020014826 active site 1173020014827 phosphorylation site [posttranslational modification] 1173020014828 intermolecular recognition site; other site 1173020014829 dimerization interface [polypeptide binding]; other site 1173020014830 Response regulator receiver domain; Region: Response_reg; pfam00072 1173020014831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020014832 active site 1173020014833 phosphorylation site [posttranslational modification] 1173020014834 intermolecular recognition site; other site 1173020014835 dimerization interface [polypeptide binding]; other site 1173020014836 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173020014837 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173020014838 metal binding site [ion binding]; metal-binding site 1173020014839 active site 1173020014840 I-site; other site 1173020014841 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1173020014842 dimerization interface [polypeptide binding]; other site 1173020014843 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1173020014844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 1173020014845 Domain of unknown function DUF302; Region: DUF302; pfam03625 1173020014846 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 1173020014847 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1173020014848 Predicted membrane protein [Function unknown]; Region: COG4803 1173020014849 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1173020014850 metal-binding site [ion binding] 1173020014851 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1173020014852 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173020014853 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1173020014854 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173020014855 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1173020014856 FtsJ-like methyltransferase; Region: FtsJ; cl17430 1173020014857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020014858 S-adenosylmethionine binding site [chemical binding]; other site 1173020014859 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1173020014860 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1173020014861 putative di-iron ligands [ion binding]; other site 1173020014862 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020014863 active site 1173020014864 Int/Topo IB signature motif; other site 1173020014865 DNA binding site [nucleotide binding] 1173020014866 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020014867 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020014868 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1173020014869 active site 1173020014870 DNA binding site [nucleotide binding] 1173020014871 Int/Topo IB signature motif; other site 1173020014872 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 1173020014873 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 1173020014874 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1173020014875 alpha-glucosidase; Provisional; Region: PRK10137 1173020014876 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 1173020014877 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1173020014878 putative active site [active] 1173020014879 transaldolase; Provisional; Region: PRK03903 1173020014880 catalytic residue [active] 1173020014881 glucokinase, proteobacterial type; Region: glk; TIGR00749 1173020014882 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1173020014883 nucleotide binding site [chemical binding]; other site 1173020014884 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1173020014885 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1173020014886 putative active site; other site 1173020014887 catalytic residue [active] 1173020014888 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1173020014889 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1173020014890 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173020014891 catalytic core [active] 1173020014892 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173020014893 non-specific DNA binding site [nucleotide binding]; other site 1173020014894 salt bridge; other site 1173020014895 sequence-specific DNA binding site [nucleotide binding]; other site 1173020014896 Clp amino terminal domain; Region: Clp_N; pfam02861 1173020014897 Predicted transcriptional regulators [Transcription]; Region: COG1733 1173020014898 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1173020014899 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1173020014900 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1173020014901 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173020014902 binding surface 1173020014903 TPR motif; other site 1173020014904 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1173020014905 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1173020014906 Homeodomain-like domain; Region: HTH_23; pfam13384 1173020014907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1173020014908 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173020014909 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173020014910 ligand binding site [chemical binding]; other site 1173020014911 flexible hinge region; other site 1173020014912 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173020014913 putative switch regulator; other site 1173020014914 non-specific DNA interactions [nucleotide binding]; other site 1173020014915 DNA binding site [nucleotide binding] 1173020014916 sequence specific DNA binding site [nucleotide binding]; other site 1173020014917 putative cAMP binding site [chemical binding]; other site 1173020014918 short chain dehydrogenase; Validated; Region: PRK08264 1173020014919 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173020014920 NAD(P) binding site [chemical binding]; other site 1173020014921 active site 1173020014922 tropinone reductase; Provisional; Region: PRK09242 1173020014923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173020014924 NAD(P) binding site [chemical binding]; other site 1173020014925 active site 1173020014926 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1173020014927 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1173020014928 C-terminal domain interface [polypeptide binding]; other site 1173020014929 GSH binding site (G-site) [chemical binding]; other site 1173020014930 dimer interface [polypeptide binding]; other site 1173020014931 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 1173020014932 dimer interface [polypeptide binding]; other site 1173020014933 N-terminal domain interface [polypeptide binding]; other site 1173020014934 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 1173020014935 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173020014936 NAD(P) binding site [chemical binding]; other site 1173020014937 active site 1173020014938 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1173020014939 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1173020014940 active site 1173020014941 TDP-binding site; other site 1173020014942 acceptor substrate-binding pocket; other site 1173020014943 homodimer interface [polypeptide binding]; other site 1173020014944 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173020014945 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173020014946 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1173020014947 Cytochrome P450; Region: p450; cl12078 1173020014948 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020014949 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173020014950 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020014951 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1173020014952 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173020014953 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1173020014954 dimerization interface [polypeptide binding]; other site 1173020014955 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1173020014956 putative catalytic residues [active] 1173020014957 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173020014958 catalytic residues [active] 1173020014959 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173020014960 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173020014961 ligand binding site [chemical binding]; other site 1173020014962 flexible hinge region; other site 1173020014963 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173020014964 putative switch regulator; other site 1173020014965 non-specific DNA interactions [nucleotide binding]; other site 1173020014966 DNA binding site [nucleotide binding] 1173020014967 sequence specific DNA binding site [nucleotide binding]; other site 1173020014968 putative cAMP binding site [chemical binding]; other site 1173020014969 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020014970 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020014971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020014972 ATP binding site [chemical binding]; other site 1173020014973 Mg2+ binding site [ion binding]; other site 1173020014974 G-X-G motif; other site 1173020014975 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1173020014976 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1173020014977 DNA binding residues [nucleotide binding] 1173020014978 drug binding residues [chemical binding]; other site 1173020014979 dimer interface [polypeptide binding]; other site 1173020014980 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1173020014981 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1173020014982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173020014983 NAD(P) binding site [chemical binding]; other site 1173020014984 active site 1173020014985 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173020014986 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173020014987 ligand binding site [chemical binding]; other site 1173020014988 flexible hinge region; other site 1173020014989 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1173020014990 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1173020014991 homodecamer interface [polypeptide binding]; other site 1173020014992 GTP cyclohydrolase I; Provisional; Region: PLN03044 1173020014993 active site 1173020014994 putative catalytic site residues [active] 1173020014995 zinc binding site [ion binding]; other site 1173020014996 GTP-CH-I/GFRP interaction surface; other site 1173020014997 Electron transfer DM13; Region: DM13; pfam10517 1173020014998 multidrug efflux protein; Reviewed; Region: PRK01766 1173020014999 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1173020015000 cation binding site [ion binding]; other site 1173020015001 MarR family; Region: MarR_2; pfam12802 1173020015002 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020015003 Coenzyme A binding pocket [chemical binding]; other site 1173020015004 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1173020015005 SurA N-terminal domain; Region: SurA_N; pfam09312 1173020015006 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1173020015007 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1173020015008 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1173020015009 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1173020015010 catalytic residues [active] 1173020015011 catalytic nucleophile [active] 1173020015012 Presynaptic Site I dimer interface [polypeptide binding]; other site 1173020015013 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1173020015014 Synaptic Flat tetramer interface [polypeptide binding]; other site 1173020015015 Synaptic Site I dimer interface [polypeptide binding]; other site 1173020015016 DNA binding site [nucleotide binding] 1173020015017 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1173020015018 DNA-binding interface [nucleotide binding]; DNA binding site 1173020015019 Integrase core domain; Region: rve; pfam00665 1173020015020 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1173020015021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020015022 Walker A motif; other site 1173020015023 ATP binding site [chemical binding]; other site 1173020015024 Walker B motif; other site 1173020015025 arginine finger; other site 1173020015026 DDE superfamily endonuclease; Region: DDE_5; cl17874 1173020015027 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173020015028 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173020015029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173020015030 NAD(P) binding site [chemical binding]; other site 1173020015031 active site 1173020015032 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 1173020015033 putative dimer interface [polypeptide binding]; other site 1173020015034 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173020015035 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 1173020015036 active site 1173020015037 catalytic residues [active] 1173020015038 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 1173020015039 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1173020015040 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1173020015041 DNA binding residues [nucleotide binding] 1173020015042 dimer interface [polypeptide binding]; other site 1173020015043 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1173020015044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020015045 S-adenosylmethionine binding site [chemical binding]; other site 1173020015046 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1173020015047 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1173020015048 active site 1173020015049 TDP-binding site; other site 1173020015050 acceptor substrate-binding pocket; other site 1173020015051 homodimer interface [polypeptide binding]; other site 1173020015052 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1173020015053 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173020015054 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1173020015055 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1173020015056 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173020015057 Coenzyme A binding pocket [chemical binding]; other site 1173020015058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020015059 Coenzyme A binding pocket [chemical binding]; other site 1173020015060 SnoaL-like domain; Region: SnoaL_3; pfam13474 1173020015061 SnoaL-like domain; Region: SnoaL_2; pfam12680 1173020015062 MarR family; Region: MarR_2; cl17246 1173020015063 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1173020015064 EamA-like transporter family; Region: EamA; pfam00892 1173020015065 EamA-like transporter family; Region: EamA; pfam00892 1173020015066 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1173020015067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020015068 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173020015069 Coenzyme A binding pocket [chemical binding]; other site 1173020015070 Helix-turn-helix domain; Region: HTH_18; pfam12833 1173020015071 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020015072 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1173020015073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020015074 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173020015075 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020015076 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173020015077 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173020015078 active site 1173020015079 catalytic tetrad [active] 1173020015080 short chain dehydrogenase; Provisional; Region: PRK06172 1173020015081 classical (c) SDRs; Region: SDR_c; cd05233 1173020015082 NAD(P) binding site [chemical binding]; other site 1173020015083 active site 1173020015084 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1173020015085 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173020015086 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1173020015087 classical (c) SDRs; Region: SDR_c; cd05233 1173020015088 NAD(P) binding site [chemical binding]; other site 1173020015089 active site 1173020015090 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1173020015091 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1173020015092 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020015093 putative active site [active] 1173020015094 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1173020015095 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1173020015096 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1173020015097 active site 1173020015098 substrate binding site [chemical binding]; other site 1173020015099 ATP binding site [chemical binding]; other site 1173020015100 Phosphotransferase enzyme family; Region: APH; pfam01636 1173020015101 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1173020015102 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1173020015103 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173020015104 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173020015105 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1173020015106 MarR family; Region: MarR; pfam01047 1173020015107 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1173020015108 SelR domain; Region: SelR; pfam01641 1173020015109 methionine sulfoxide reductase A; Provisional; Region: PRK13014 1173020015110 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1173020015111 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1173020015112 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173020015113 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173020015114 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 1173020015115 short chain dehydrogenase; Validated; Region: PRK08264 1173020015116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173020015117 NAD(P) binding site [chemical binding]; other site 1173020015118 active site 1173020015119 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1173020015120 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173020015121 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1173020015122 putative effector binding pocket; other site 1173020015123 dimerization interface [polypeptide binding]; other site 1173020015124 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020015125 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173020015126 Coenzyme A binding pocket [chemical binding]; other site 1173020015127 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1173020015128 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1173020015129 Moco binding site; other site 1173020015130 metal coordination site [ion binding]; other site 1173020015131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020015132 Coenzyme A binding pocket [chemical binding]; other site 1173020015133 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1173020015134 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1173020015135 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1173020015136 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1173020015137 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173020015138 catalytic residues [active] 1173020015139 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1173020015140 EamA-like transporter family; Region: EamA; pfam00892 1173020015141 EamA-like transporter family; Region: EamA; pfam00892 1173020015142 AAA domain; Region: AAA_33; pfam13671 1173020015143 AAA domain; Region: AAA_17; pfam13207 1173020015144 The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain; Region: ASCH; smart01022 1173020015145 MarR family; Region: MarR_2; cl17246 1173020015146 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1173020015147 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1173020015148 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1173020015149 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173020015150 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020015151 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1173020015152 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020015153 dimer interface [polypeptide binding]; other site 1173020015154 phosphorylation site [posttranslational modification] 1173020015155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020015156 ATP binding site [chemical binding]; other site 1173020015157 Mg2+ binding site [ion binding]; other site 1173020015158 G-X-G motif; other site 1173020015159 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173020015160 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173020015161 GAF domain; Region: GAF; pfam01590 1173020015162 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173020015163 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173020015164 putative active site [active] 1173020015165 heme pocket [chemical binding]; other site 1173020015166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020015167 dimer interface [polypeptide binding]; other site 1173020015168 phosphorylation site [posttranslational modification] 1173020015169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020015170 ATP binding site [chemical binding]; other site 1173020015171 Mg2+ binding site [ion binding]; other site 1173020015172 G-X-G motif; other site 1173020015173 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1173020015174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173020015175 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1173020015176 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173020015177 Coenzyme A binding pocket [chemical binding]; other site 1173020015178 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 1173020015179 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020015180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020015181 active site 1173020015182 phosphorylation site [posttranslational modification] 1173020015183 intermolecular recognition site; other site 1173020015184 dimerization interface [polypeptide binding]; other site 1173020015185 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020015186 DNA binding site [nucleotide binding] 1173020015187 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 1173020015188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1173020015189 Walker A motif; other site 1173020015190 ATP binding site [chemical binding]; other site 1173020015191 Walker B motif; other site 1173020015192 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1173020015193 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173020015194 non-specific DNA binding site [nucleotide binding]; other site 1173020015195 salt bridge; other site 1173020015196 sequence-specific DNA binding site [nucleotide binding]; other site 1173020015197 Domain of unknown function (DUF955); Region: DUF955; cl01076 1173020015198 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 1173020015199 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1173020015200 TIGR02594 family protein; Region: TIGR02594 1173020015201 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173020015202 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 1173020015203 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1173020015204 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020015205 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1173020015206 active site 1173020015207 DNA binding site [nucleotide binding] 1173020015208 Int/Topo IB signature motif; other site 1173020015209 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020015210 putative active site [active] 1173020015211 Fic/DOC family; Region: Fic; pfam02661 1173020015212 Fic/DOC family; Region: Fic; cl00960 1173020015213 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 1173020015214 inhibitor binding site; inhibition site 1173020015215 catalytic motif [active] 1173020015216 Catalytic residue [active] 1173020015217 Active site flap [active] 1173020015218 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1173020015219 SWIM zinc finger; Region: SWIM; pfam04434 1173020015220 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1173020015221 SNF2 Helicase protein; Region: DUF3670; pfam12419 1173020015222 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173020015223 ATP binding site [chemical binding]; other site 1173020015224 putative Mg++ binding site [ion binding]; other site 1173020015225 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173020015226 nucleotide binding region [chemical binding]; other site 1173020015227 ATP-binding site [chemical binding]; other site 1173020015228 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 1173020015229 ParB-like nuclease domain; Region: ParB; smart00470 1173020015230 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173020015231 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173020015232 P-loop; other site 1173020015233 Magnesium ion binding site [ion binding]; other site 1173020015234 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173020015235 Magnesium ion binding site [ion binding]; other site 1173020015236 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1173020015237 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1173020015238 Mg binding site [ion binding]; other site 1173020015239 nucleotide binding site [chemical binding]; other site 1173020015240 putative protofilament interface [polypeptide binding]; other site 1173020015241 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173020015242 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1173020015243 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173020015244 active site 1173020015245 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020015246 putative active site [active] 1173020015247 RES domain; Region: RES; pfam08808 1173020015248 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1173020015249 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1173020015250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173020015251 S-adenosylmethionine binding site [chemical binding]; other site 1173020015252 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 1173020015253 Helicase_C-like; Region: Helicase_C_4; pfam13871 1173020015254 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1173020015255 metal ion-dependent adhesion site (MIDAS); other site 1173020015256 Domain of unknown function (DUF932); Region: DUF932; cl12129 1173020015257 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1173020015258 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1173020015259 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1173020015260 dimer interface [polypeptide binding]; other site 1173020015261 ssDNA binding site [nucleotide binding]; other site 1173020015262 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1173020015263 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020015264 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1173020015265 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173020015266 ATP binding site [chemical binding]; other site 1173020015267 putative Mg++ binding site [ion binding]; other site 1173020015268 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173020015269 nucleotide binding region [chemical binding]; other site 1173020015270 ATP-binding site [chemical binding]; other site 1173020015271 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 1173020015272 TIGR02687 family protein; Region: TIGR02687 1173020015273 PglZ domain; Region: PglZ; pfam08665 1173020015274 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173020015275 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1173020015276 non-specific DNA binding site [nucleotide binding]; other site 1173020015277 salt bridge; other site 1173020015278 sequence-specific DNA binding site [nucleotide binding]; other site 1173020015279 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1173020015280 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1173020015281 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1173020015282 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173020015283 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 1173020015284 TPR repeat; Region: TPR_11; pfam13414 1173020015285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020015286 binding surface 1173020015287 TPR motif; other site 1173020015288 TPR repeat; Region: TPR_11; pfam13414 1173020015289 TPR repeat; Region: TPR_11; pfam13414 1173020015290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020015291 binding surface 1173020015292 TPR motif; other site 1173020015293 TPR repeat; Region: TPR_11; pfam13414 1173020015294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173020015295 binding surface 1173020015296 TPR motif; other site 1173020015297 AAA-like domain; Region: AAA_10; pfam12846 1173020015298 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 1173020015299 Fic family protein [Function unknown]; Region: COG3177 1173020015300 Fic/DOC family; Region: Fic; pfam02661 1173020015301 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 1173020015302 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1173020015303 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1173020015304 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173020015305 non-specific DNA binding site [nucleotide binding]; other site 1173020015306 salt bridge; other site 1173020015307 sequence-specific DNA binding site [nucleotide binding]; other site 1173020015308 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1173020015309 Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628 1173020015310 5' RNA guide strand anchoring site; other site 1173020015311 active site 1173020015312 AAA-like domain; Region: AAA_10; pfam12846 1173020015313 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1173020015314 Ycf46; Provisional; Region: ycf46; CHL00195 1173020015315 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 1173020015316 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1173020015317 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1173020015318 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1173020015319 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1173020015320 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1173020015321 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 1173020015322 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 1173020015323 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 1173020015324 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1173020015325 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173020015326 non-specific DNA binding site [nucleotide binding]; other site 1173020015327 salt bridge; other site 1173020015328 sequence-specific DNA binding site [nucleotide binding]; other site 1173020015329 Double zinc ribbon; Region: DZR; pfam12773 1173020015330 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1173020015331 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020015332 active site 1173020015333 DNA binding site [nucleotide binding] 1173020015334 Int/Topo IB signature motif; other site 1173020015335 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1173020015336 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1173020015337 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1173020015338 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1173020015339 metal-binding site [ion binding] 1173020015340 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173020015341 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1173020015342 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1173020015343 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1173020015344 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1173020015345 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1173020015346 flavodoxin FldA; Validated; Region: PRK09267 1173020015347 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 1173020015348 metal-binding site [ion binding] 1173020015349 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1173020015350 Zn(II)-responsive transcriptional regulator; Region: ZntR; TIGR02043 1173020015351 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1173020015352 DNA binding residues [nucleotide binding] 1173020015353 dimer interface [polypeptide binding]; other site 1173020015354 metal binding site [ion binding]; metal-binding site 1173020015355 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 1173020015356 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1173020015357 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1173020015358 Integral membrane protein TerC family; Region: TerC; cl10468 1173020015359 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1173020015360 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 1173020015361 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1173020015362 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173020015363 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1173020015364 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1173020015365 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173020015366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173020015367 active site 1173020015368 phosphorylation site [posttranslational modification] 1173020015369 intermolecular recognition site; other site 1173020015370 dimerization interface [polypeptide binding]; other site 1173020015371 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173020015372 DNA binding site [nucleotide binding] 1173020015373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173020015374 dimer interface [polypeptide binding]; other site 1173020015375 phosphorylation site [posttranslational modification] 1173020015376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173020015377 ATP binding site [chemical binding]; other site 1173020015378 Mg2+ binding site [ion binding]; other site 1173020015379 G-X-G motif; other site 1173020015380 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173020015381 active site 1173020015382 DNA binding site [nucleotide binding] 1173020015383 Int/Topo IB signature motif; other site 1173020015384 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 1173020015385 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173020015386 putative active site [active] 1173020015387 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1173020015388 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173020015389 active site 1173020015390 ParB-like nuclease domain; Region: ParBc; pfam02195 1173020015391 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173020015392 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173020015393 P-loop; other site 1173020015394 Magnesium ion binding site [ion binding]; other site 1173020015395 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173020015396 Magnesium ion binding site [ion binding]; other site 1173020015397 Transposase; Region: HTH_Tnp_1; cl17663 1173020015398 Winged helix-turn helix; Region: HTH_29; pfam13551 1173020015399 AAA-like domain; Region: AAA_10; pfam12846 1173020015400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1173020015401 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1173020015402 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 1173020015403 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1173020015404 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173020015405 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1173020015406 Walker A motif; other site 1173020015407 ATP binding site [chemical binding]; other site 1173020015408 Walker B motif; other site 1173020015409 arginine finger; other site 1173020015410 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203