-- dump date 20140619_031006 -- class Genbank::misc_feature -- table misc_feature_note -- id note 485918000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 485918000002 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 485918000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918000004 Walker A motif; other site 485918000005 ATP binding site [chemical binding]; other site 485918000006 Walker B motif; other site 485918000007 arginine finger; other site 485918000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 485918000009 DnaA box-binding interface [nucleotide binding]; other site 485918000010 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918000011 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918000012 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918000013 DNA binding residues [nucleotide binding] 485918000014 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918000015 FecR protein; Region: FecR; pfam04773 485918000016 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918000017 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918000018 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918000019 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918000020 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918000021 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918000022 SusD family; Region: SusD; pfam07980 485918000023 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 485918000024 putative active site [active] 485918000025 catalytic site [active] 485918000026 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 485918000027 Alkaline phosphatase homologues; Region: alkPPc; smart00098 485918000028 active site 485918000029 dimer interface [polypeptide binding]; other site 485918000030 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 485918000031 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 485918000032 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit [DNA replication, recombination, and repair]; Region: GyrB; COG0187 485918000033 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 485918000034 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918000035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918000036 active site 485918000037 phosphorylation site [posttranslational modification] 485918000038 intermolecular recognition site; other site 485918000039 dimerization interface [polypeptide binding]; other site 485918000040 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918000041 DNA binding residues [nucleotide binding] 485918000042 dimerization interface [polypeptide binding]; other site 485918000043 Histidine kinase; Region: HisKA_3; pfam07730 485918000044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918000045 ATP binding site [chemical binding]; other site 485918000046 Mg2+ binding site [ion binding]; other site 485918000047 G-X-G motif; other site 485918000048 Caspase domain; Region: Peptidase_C14; pfam00656 485918000049 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 485918000050 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 485918000051 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 485918000052 PA/protease or protease-like domain interface [polypeptide binding]; other site 485918000053 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 485918000054 metal binding site [ion binding]; metal-binding site 485918000055 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 485918000056 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 485918000057 non-specific DNA binding site [nucleotide binding]; other site 485918000058 salt bridge; other site 485918000059 sequence-specific DNA binding site [nucleotide binding]; other site 485918000060 Domain of unknown function (DUF955); Region: DUF955; cl01076 485918000061 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 485918000062 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 485918000063 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 485918000064 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918000065 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 485918000066 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 485918000067 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 485918000068 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 485918000069 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918000070 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 485918000071 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 485918000072 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 485918000073 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 485918000074 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918000075 hypothetical protein; Provisional; Region: PRK07208 485918000076 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 485918000077 Transposase; Region: HTH_Tnp_1; pfam01527 485918000078 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 485918000079 DNA-binding interface [nucleotide binding]; DNA binding site 485918000080 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 485918000081 Integrase core domain; Region: rve; pfam00665 485918000082 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 485918000083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918000084 Walker A motif; other site 485918000085 ATP binding site [chemical binding]; other site 485918000086 Walker B motif; other site 485918000087 arginine finger; other site 485918000088 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 485918000089 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918000090 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918000091 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918000092 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918000093 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918000094 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918000095 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918000096 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918000097 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918000098 DNA binding residues [nucleotide binding] 485918000099 FecR protein; Region: FecR; pfam04773 485918000100 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918000101 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918000102 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918000103 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 485918000104 DNA binding residues [nucleotide binding] 485918000105 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918000106 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 485918000107 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918000108 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 485918000109 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 485918000110 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918000111 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918000112 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918000113 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918000114 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918000115 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918000116 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918000117 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918000118 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918000119 DNA binding residues [nucleotide binding] 485918000120 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918000121 FecR protein; Region: FecR; pfam04773 485918000122 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918000123 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 485918000124 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 485918000125 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 485918000126 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 485918000127 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918000128 hypothetical protein; Provisional; Region: PRK07208 485918000129 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 485918000130 UDP-galactopyranose mutase; Region: GLF; pfam03275 485918000131 helicase 45; Provisional; Region: PTZ00424 485918000132 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 485918000133 ATP binding site [chemical binding]; other site 485918000134 Mg++ binding site [ion binding]; other site 485918000135 motif III; other site 485918000136 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 485918000137 nucleotide binding region [chemical binding]; other site 485918000138 ATP-binding site [chemical binding]; other site 485918000139 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 485918000140 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 485918000141 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 485918000142 nudix motif; other site 485918000143 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 485918000144 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 485918000145 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 485918000146 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 485918000147 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 485918000148 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 485918000149 active site 485918000150 metal binding site [ion binding]; metal-binding site 485918000151 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 485918000152 Ca binding site [ion binding]; other site 485918000153 Ca binding site (active) [ion binding]; other site 485918000154 ligand binding site [chemical binding]; other site 485918000155 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918000156 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918000157 TPR motif; other site 485918000158 TPR repeat; Region: TPR_11; pfam13414 485918000159 binding surface 485918000160 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 485918000161 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 485918000162 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 485918000163 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 485918000164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918000165 homodimer interface [polypeptide binding]; other site 485918000166 catalytic residue [active] 485918000167 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 485918000168 protein-splicing catalytic site; other site 485918000169 thioester formation/cholesterol transfer; other site 485918000170 elongation factor G; Reviewed; Region: PRK12739 485918000171 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 485918000172 G1 box; other site 485918000173 putative GEF interaction site [polypeptide binding]; other site 485918000174 GTP/Mg2+ binding site [chemical binding]; other site 485918000175 Switch I region; other site 485918000176 G2 box; other site 485918000177 G3 box; other site 485918000178 Switch II region; other site 485918000179 G4 box; other site 485918000180 G5 box; other site 485918000181 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 485918000182 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 485918000183 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 485918000184 short chain dehydrogenase; Provisional; Region: PRK08263 485918000185 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918000186 NADP binding site [chemical binding]; other site 485918000187 active site 485918000188 steroid binding site; other site 485918000189 Alginate lyase; Region: Alginate_lyase; pfam05426 485918000190 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 485918000191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 485918000192 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 485918000193 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 485918000194 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 485918000195 catalytic residue [active] 485918000196 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918000197 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 485918000198 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918000199 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918000200 DNA binding residues [nucleotide binding] 485918000201 dimerization interface [polypeptide binding]; other site 485918000202 methionine sulfoxide reductase A; Provisional; Region: PRK14054 485918000203 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 485918000204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918000205 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 485918000206 Walker A motif; other site 485918000207 ATP binding site [chemical binding]; other site 485918000208 Walker B motif; other site 485918000209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918000210 AAA domain; Region: AAA_21; pfam13304 485918000211 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 485918000212 G1 box; other site 485918000213 Walker A/P-loop; other site 485918000214 GTP/Mg2+ binding site [chemical binding]; other site 485918000215 ATP binding site [chemical binding]; other site 485918000216 G2 box; other site 485918000217 Switch I region; other site 485918000218 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 485918000219 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 485918000220 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 485918000221 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 485918000222 PAS fold; Region: PAS_4; pfam08448 485918000223 PAS fold; Region: PAS_4; pfam08448 485918000224 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918000225 dimer interface [polypeptide binding]; other site 485918000226 phosphorylation site [posttranslational modification] 485918000227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918000228 ATP binding site [chemical binding]; other site 485918000229 Mg2+ binding site [ion binding]; other site 485918000230 G-X-G motif; other site 485918000231 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 485918000232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918000233 putative substrate translocation pore; other site 485918000234 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 485918000235 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 485918000236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918000237 active site 485918000238 phosphorylation site [posttranslational modification] 485918000239 intermolecular recognition site; other site 485918000240 dimerization interface [polypeptide binding]; other site 485918000241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918000242 Walker A motif; other site 485918000243 ATP binding site [chemical binding]; other site 485918000244 Walker B motif; other site 485918000245 arginine finger; other site 485918000246 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 485918000247 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918000248 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918000249 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918000250 Histidine kinase; Region: HisKA_2; pfam07568 485918000251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918000252 ATP binding site [chemical binding]; other site 485918000253 Mg2+ binding site [ion binding]; other site 485918000254 G-X-G motif; other site 485918000255 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918000256 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918000257 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918000258 TPR motif; other site 485918000259 binding surface 485918000260 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 485918000261 Histidine kinase; Region: HisKA_2; pfam07568 485918000262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918000263 ATP binding site [chemical binding]; other site 485918000264 Mg2+ binding site [ion binding]; other site 485918000265 G-X-G motif; other site 485918000266 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918000267 binding surface 485918000268 TPR motif; other site 485918000269 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918000270 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918000271 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 485918000272 Histidine kinase; Region: HisKA_2; pfam07568 485918000273 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918000274 ATP binding site [chemical binding]; other site 485918000275 Mg2+ binding site [ion binding]; other site 485918000276 G-X-G motif; other site 485918000277 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 485918000278 catalytic residues [active] 485918000279 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 485918000280 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 485918000281 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 485918000282 N-terminal plug; other site 485918000283 ligand-binding site [chemical binding]; other site 485918000284 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 485918000285 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 485918000286 catalytic triad [active] 485918000287 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 485918000288 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 485918000289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918000290 NAD(P) binding site [chemical binding]; other site 485918000291 active site 485918000292 short chain dehydrogenase; Provisional; Region: PRK12937 485918000293 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 485918000294 NADP binding site [chemical binding]; other site 485918000295 homodimer interface [polypeptide binding]; other site 485918000296 active site 485918000297 substrate binding site [chemical binding]; other site 485918000298 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918000299 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918000300 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 485918000301 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 485918000302 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918000303 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 485918000304 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 485918000305 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 485918000306 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918000307 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918000308 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918000309 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918000310 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 485918000311 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918000312 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918000313 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918000314 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918000315 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 485918000316 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918000317 FecR protein; Region: FecR; pfam04773 485918000318 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 485918000319 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 485918000320 gating phenylalanine in ion channel; other site 485918000321 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 485918000322 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 485918000323 MOSC domain; Region: MOSC; pfam03473 485918000324 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 485918000325 short chain dehydrogenase; Provisional; Region: PRK08263 485918000326 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918000327 NADP binding site [chemical binding]; other site 485918000328 active site 485918000329 steroid binding site; other site 485918000330 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918000331 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 485918000332 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 485918000333 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918000334 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 485918000335 active site 485918000336 metal binding site [ion binding]; metal-binding site 485918000337 SnoaL-like domain; Region: SnoaL_2; pfam12680 485918000338 short chain dehydrogenase; Provisional; Region: PRK06139 485918000339 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 485918000340 putative NAD(P) binding site [chemical binding]; other site 485918000341 active site 485918000342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 485918000343 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 485918000344 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 485918000345 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 485918000346 DNA topoisomerase I; Provisional; Region: PRK14973 485918000347 HipA N-terminal domain; Region: Couple_hipA; pfam13657 485918000348 HipA-like N-terminal domain; Region: HipA_N; pfam07805 485918000349 HipA-like C-terminal domain; Region: HipA_C; pfam07804 485918000350 Fatty acid desaturase; Region: FA_desaturase; pfam00487 485918000351 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 485918000352 putative di-iron ligands [ion binding]; other site 485918000353 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 485918000354 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 485918000355 dimer interface [polypeptide binding]; other site 485918000356 active site 485918000357 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 485918000358 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 485918000359 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 485918000360 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 485918000361 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918000362 Coenzyme A binding pocket [chemical binding]; other site 485918000363 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 485918000364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918000365 Walker A/P-loop; other site 485918000366 ATP binding site [chemical binding]; other site 485918000367 Q-loop/lid; other site 485918000368 ABC transporter signature motif; other site 485918000369 Walker B; other site 485918000370 D-loop; other site 485918000371 H-loop/switch region; other site 485918000372 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918000373 Walker A/P-loop; other site 485918000374 ATP binding site [chemical binding]; other site 485918000375 Q-loop/lid; other site 485918000376 ABC transporter signature motif; other site 485918000377 Walker B; other site 485918000378 D-loop; other site 485918000379 H-loop/switch region; other site 485918000380 MG2 domain; Region: A2M_N; pfam01835 485918000381 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 485918000382 Alpha-2-macroglobulin family; Region: A2M; pfam00207 485918000383 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 485918000384 surface patch; other site 485918000385 thioester region; other site 485918000386 specificity defining residues; other site 485918000387 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 485918000388 Transglycosylase; Region: Transgly; pfam00912 485918000389 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 485918000390 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 485918000391 recombination factor protein RarA; Reviewed; Region: PRK13342 485918000392 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918000393 Walker A motif; other site 485918000394 ATP binding site [chemical binding]; other site 485918000395 Walker B motif; other site 485918000396 arginine finger; other site 485918000397 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 485918000398 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 485918000399 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 485918000400 active site 485918000401 Zn binding site [ion binding]; other site 485918000402 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 485918000403 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918000404 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918000405 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 485918000406 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 485918000407 putative DNA binding site [nucleotide binding]; other site 485918000408 putative Zn2+ binding site [ion binding]; other site 485918000409 AsnC family; Region: AsnC_trans_reg; pfam01037 485918000410 phosphoenolpyruvate synthase; Validated; Region: PRK06464 485918000411 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 485918000412 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 485918000413 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 485918000414 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 485918000415 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918000416 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 485918000417 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918000418 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918000419 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 485918000420 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 485918000421 putative active site [active] 485918000422 putative metal binding site [ion binding]; other site 485918000423 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 485918000424 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 485918000425 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 485918000426 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 485918000427 substrate binding site; other site 485918000428 tetramer interface; other site 485918000429 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 485918000430 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 485918000431 NAD binding site [chemical binding]; other site 485918000432 homodimer interface [polypeptide binding]; other site 485918000433 active site 485918000434 substrate binding site [chemical binding]; other site 485918000435 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 485918000436 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 485918000437 PYR/PP interface [polypeptide binding]; other site 485918000438 dimer interface [polypeptide binding]; other site 485918000439 TPP binding site [chemical binding]; other site 485918000440 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 485918000441 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 485918000442 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918000443 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918000444 DNA binding residues [nucleotide binding] 485918000445 translation elongation factor aEF-2; Region: aEF-2; TIGR00490 485918000446 SnoaL-like domain; Region: SnoaL_2; pfam12680 485918000447 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918000448 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918000449 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 485918000450 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 485918000451 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 485918000452 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 485918000453 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 485918000454 rod shape-determining protein MreC; Provisional; Region: PRK13922 485918000455 rod shape-determining protein MreC; Region: MreC; pfam04085 485918000456 rod shape-determining protein MreB; Provisional; Region: PRK13927 485918000457 MreB and similar proteins; Region: MreB_like; cd10225 485918000458 nucleotide binding site [chemical binding]; other site 485918000459 Mg binding site [ion binding]; other site 485918000460 putative protofilament interaction site [polypeptide binding]; other site 485918000461 RodZ interaction site [polypeptide binding]; other site 485918000462 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 485918000463 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 485918000464 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 485918000465 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 485918000466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918000467 putative substrate translocation pore; other site 485918000468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918000469 OPT oligopeptide transporter protein; Region: OPT; cl14607 485918000470 putative oligopeptide transporter, OPT family; Region: TIGR00733 485918000471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 485918000472 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 485918000473 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 485918000474 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 485918000475 dimer interface [polypeptide binding]; other site 485918000476 putative functional site; other site 485918000477 putative MPT binding site; other site 485918000478 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 485918000479 trimer interface [polypeptide binding]; other site 485918000480 dimer interface [polypeptide binding]; other site 485918000481 putative active site [active] 485918000482 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 485918000483 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 485918000484 GTP binding site; other site 485918000485 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 485918000486 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918000487 L-aspartate oxidase; Provisional; Region: PRK09077 485918000488 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 485918000489 MoaE homodimer interface [polypeptide binding]; other site 485918000490 MoaD interaction [polypeptide binding]; other site 485918000491 active site residues [active] 485918000492 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 485918000493 MoaE interaction surface [polypeptide binding]; other site 485918000494 MoeB interaction surface [polypeptide binding]; other site 485918000495 thiocarboxylated glycine; other site 485918000496 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 485918000497 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 485918000498 hypothetical protein; Validated; Region: PRK07411 485918000499 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 485918000500 ATP binding site [chemical binding]; other site 485918000501 substrate interface [chemical binding]; other site 485918000502 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 485918000503 active site residue [active] 485918000504 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 485918000505 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918000506 Coenzyme A binding pocket [chemical binding]; other site 485918000507 seryl-tRNA synthetase; Provisional; Region: PRK05431 485918000508 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 485918000509 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 485918000510 dimer interface [polypeptide binding]; other site 485918000511 active site 485918000512 motif 1; other site 485918000513 motif 2; other site 485918000514 motif 3; other site 485918000515 NAD synthetase; Provisional; Region: PRK13981 485918000516 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 485918000517 multimer interface [polypeptide binding]; other site 485918000518 active site 485918000519 catalytic triad [active] 485918000520 protein interface 1 [polypeptide binding]; other site 485918000521 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 485918000522 homodimer interface [polypeptide binding]; other site 485918000523 NAD binding pocket [chemical binding]; other site 485918000524 ATP binding pocket [chemical binding]; other site 485918000525 Mg binding site [ion binding]; other site 485918000526 active-site loop [active] 485918000527 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 485918000528 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 485918000529 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 485918000530 Methyltransferase domain; Region: Methyltransf_23; pfam13489 485918000531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918000532 S-adenosylmethionine binding site [chemical binding]; other site 485918000533 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 485918000534 YceI-like domain; Region: YceI; pfam04264 485918000535 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 485918000536 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 485918000537 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 485918000538 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 485918000539 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918000540 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 485918000541 dimer interface [polypeptide binding]; other site 485918000542 substrate binding site [chemical binding]; other site 485918000543 metal binding site [ion binding]; metal-binding site 485918000544 cysteine desulfurase; Provisional; Region: PRK14012 485918000545 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 485918000546 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 485918000547 catalytic residue [active] 485918000548 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 485918000549 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 485918000550 trimerization site [polypeptide binding]; other site 485918000551 active site 485918000552 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 485918000553 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 485918000554 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 485918000555 putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930 485918000556 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 485918000557 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 485918000558 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 485918000559 active site 485918000560 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 485918000561 dimer interface [polypeptide binding]; other site 485918000562 substrate binding site [chemical binding]; other site 485918000563 catalytic residues [active] 485918000564 lipoprotein signal peptidase; Provisional; Region: PRK14788 485918000565 lipoprotein signal peptidase; Provisional; Region: PRK14787 485918000566 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918000567 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918000568 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918000569 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918000570 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 485918000571 fumarate hydratase; Reviewed; Region: fumC; PRK00485 485918000572 Class II fumarases; Region: Fumarase_classII; cd01362 485918000573 active site 485918000574 tetramer interface [polypeptide binding]; other site 485918000575 enoyl-CoA hydratase; Provisional; Region: PRK07658 485918000576 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 485918000577 substrate binding site [chemical binding]; other site 485918000578 oxyanion hole (OAH) forming residues; other site 485918000579 trimer interface [polypeptide binding]; other site 485918000580 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 485918000581 B12 binding site [chemical binding]; other site 485918000582 cobalt ligand [ion binding]; other site 485918000583 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 485918000584 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 485918000585 active site 485918000586 HIGH motif; other site 485918000587 nucleotide binding site [chemical binding]; other site 485918000588 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 485918000589 KMSKS motif; other site 485918000590 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 485918000591 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 485918000592 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 485918000593 HIGH motif; other site 485918000594 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 485918000595 active site 485918000596 KMSKS motif; other site 485918000597 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 485918000598 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 485918000599 NodB motif; other site 485918000600 active site 485918000601 catalytic site [active] 485918000602 metal binding site [ion binding]; metal-binding site 485918000603 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 485918000604 active site 485918000605 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 485918000606 active site 485918000607 homodimer interface [polypeptide binding]; other site 485918000608 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 485918000609 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 485918000610 SWIM zinc finger; Region: SWIM; pfam04434 485918000611 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 485918000612 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918000613 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 485918000614 putative Zn2+ binding site [ion binding]; other site 485918000615 putative DNA binding site [nucleotide binding]; other site 485918000616 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 485918000617 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 485918000618 NADP binding site [chemical binding]; other site 485918000619 Epoxide hydrolase N terminus; Region: EHN; pfam06441 485918000620 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918000621 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 485918000622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918000623 active site 485918000624 phosphorylation site [posttranslational modification] 485918000625 intermolecular recognition site; other site 485918000626 dimerization interface [polypeptide binding]; other site 485918000627 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 485918000628 DNA binding site [nucleotide binding] 485918000629 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918000630 dimer interface [polypeptide binding]; other site 485918000631 phosphorylation site [posttranslational modification] 485918000632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918000633 ATP binding site [chemical binding]; other site 485918000634 Mg2+ binding site [ion binding]; other site 485918000635 G-X-G motif; other site 485918000636 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 485918000637 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918000638 catalytic residues [active] 485918000639 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918000640 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 485918000641 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918000642 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 485918000643 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918000644 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918000645 ligand binding site [chemical binding]; other site 485918000646 flexible hinge region; other site 485918000647 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 485918000648 Protein of unknown function, DUF606; Region: DUF606; pfam04657 485918000649 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918000650 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918000651 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 485918000652 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918000653 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 485918000654 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 485918000655 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 485918000656 Response regulator receiver domain; Region: Response_reg; pfam00072 485918000657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918000658 active site 485918000659 phosphorylation site [posttranslational modification] 485918000660 intermolecular recognition site; other site 485918000661 dimerization interface [polypeptide binding]; other site 485918000662 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918000663 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 485918000664 Walker A motif; other site 485918000665 ATP binding site [chemical binding]; other site 485918000666 Walker B motif; other site 485918000667 arginine finger; other site 485918000668 Transcriptional regulator [Transcription]; Region: LysR; COG0583 485918000669 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 485918000670 LysR substrate binding domain; Region: LysR_substrate; pfam03466 485918000671 dimerization interface [polypeptide binding]; other site 485918000672 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918000673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918000674 active site 485918000675 phosphorylation site [posttranslational modification] 485918000676 intermolecular recognition site; other site 485918000677 dimerization interface [polypeptide binding]; other site 485918000678 LytTr DNA-binding domain; Region: LytTR; smart00850 485918000679 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 485918000680 conserved cys residue [active] 485918000681 Histidine kinase; Region: His_kinase; pfam06580 485918000682 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918000683 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918000684 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918000685 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918000686 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918000687 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918000688 short chain dehydrogenase; Provisional; Region: PRK06180 485918000689 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918000690 NADP binding site [chemical binding]; other site 485918000691 active site 485918000692 steroid binding site; other site 485918000693 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-2; cd12809 485918000694 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918000695 catalytic site [active] 485918000696 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 485918000697 amidase catalytic site [active] 485918000698 Zn binding residues [ion binding]; other site 485918000699 substrate binding site [chemical binding]; other site 485918000700 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 485918000701 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 485918000702 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 485918000703 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918000704 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918000705 ligand binding site [chemical binding]; other site 485918000706 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918000707 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918000708 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918000709 DNA binding residues [nucleotide binding] 485918000710 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918000711 FecR protein; Region: FecR; pfam04773 485918000712 Polycystin cation channel protein; Provisional; Region: PLN03223 485918000713 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918000714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918000715 active site 485918000716 phosphorylation site [posttranslational modification] 485918000717 intermolecular recognition site; other site 485918000718 dimerization interface [polypeptide binding]; other site 485918000719 LytTr DNA-binding domain; Region: LytTR; smart00850 485918000720 Histidine kinase; Region: His_kinase; pfam06580 485918000721 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918000722 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918000723 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 485918000724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918000725 NAD(P) binding site [chemical binding]; other site 485918000726 active site 485918000727 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918000728 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918000729 ligand binding site [chemical binding]; other site 485918000730 flexible hinge region; other site 485918000731 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 485918000732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 485918000733 SPFH domain / Band 7 family; Region: Band_7; pfam01145 485918000734 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 485918000735 V-type ATP synthase subunit E; Provisional; Region: PRK02292 485918000736 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 485918000737 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 485918000738 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 485918000739 dimerization interface [polypeptide binding]; other site 485918000740 DPS ferroxidase diiron center [ion binding]; other site 485918000741 ion pore; other site 485918000742 Predicted membrane protein [Function unknown]; Region: COG2259 485918000743 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 485918000744 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 485918000745 active site 485918000746 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 485918000747 catalytic triad [active] 485918000748 dimer interface [polypeptide binding]; other site 485918000749 conserved cis-peptide bond; other site 485918000750 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 485918000751 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 485918000752 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 485918000753 Response regulator receiver domain; Region: Response_reg; pfam00072 485918000754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918000755 active site 485918000756 phosphorylation site [posttranslational modification] 485918000757 intermolecular recognition site; other site 485918000758 dimerization interface [polypeptide binding]; other site 485918000759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918000760 dimer interface [polypeptide binding]; other site 485918000761 phosphorylation site [posttranslational modification] 485918000762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918000763 ATP binding site [chemical binding]; other site 485918000764 Mg2+ binding site [ion binding]; other site 485918000765 G-X-G motif; other site 485918000766 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 485918000767 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 485918000768 dimerization interface [polypeptide binding]; other site 485918000769 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 485918000770 dimerization interface [polypeptide binding]; other site 485918000771 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 485918000772 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 485918000773 dimerization interface [polypeptide binding]; other site 485918000774 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 485918000775 dimerization interface [polypeptide binding]; other site 485918000776 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 485918000777 dimerization interface [polypeptide binding]; other site 485918000778 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 485918000779 dimerization interface [polypeptide binding]; other site 485918000780 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 485918000781 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 485918000782 dimerization interface [polypeptide binding]; other site 485918000783 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 485918000784 dimerization interface [polypeptide binding]; other site 485918000785 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 485918000786 dimerization interface [polypeptide binding]; other site 485918000787 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 485918000788 dimerization interface [polypeptide binding]; other site 485918000789 GAF domain; Region: GAF_2; pfam13185 485918000790 GAF domain; Region: GAF; pfam01590 485918000791 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918000792 dimer interface [polypeptide binding]; other site 485918000793 phosphorylation site [posttranslational modification] 485918000794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918000795 ATP binding site [chemical binding]; other site 485918000796 Mg2+ binding site [ion binding]; other site 485918000797 G-X-G motif; other site 485918000798 Response regulator receiver domain; Region: Response_reg; pfam00072 485918000799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918000800 active site 485918000801 phosphorylation site [posttranslational modification] 485918000802 intermolecular recognition site; other site 485918000803 dimerization interface [polypeptide binding]; other site 485918000804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918000805 active site 485918000806 phosphorylation site [posttranslational modification] 485918000807 intermolecular recognition site; other site 485918000808 dimerization interface [polypeptide binding]; other site 485918000809 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 485918000810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918000811 active site 485918000812 phosphorylation site [posttranslational modification] 485918000813 intermolecular recognition site; other site 485918000814 dimerization interface [polypeptide binding]; other site 485918000815 Response regulator receiver domain; Region: Response_reg; pfam00072 485918000816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918000817 active site 485918000818 phosphorylation site [posttranslational modification] 485918000819 intermolecular recognition site; other site 485918000820 dimerization interface [polypeptide binding]; other site 485918000821 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 485918000822 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 485918000823 ATP binding site [chemical binding]; other site 485918000824 putative Mg++ binding site [ion binding]; other site 485918000825 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 485918000826 nucleotide binding region [chemical binding]; other site 485918000827 ATP-binding site [chemical binding]; other site 485918000828 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 485918000829 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918000830 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918000831 DNA binding residues [nucleotide binding] 485918000832 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 485918000833 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 485918000834 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918000835 PAS fold; Region: PAS_3; pfam08447 485918000836 putative active site [active] 485918000837 heme pocket [chemical binding]; other site 485918000838 PAS fold; Region: PAS; pfam00989 485918000839 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 485918000840 putative active site [active] 485918000841 heme pocket [chemical binding]; other site 485918000842 PAS domain S-box; Region: sensory_box; TIGR00229 485918000843 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918000844 putative active site [active] 485918000845 heme pocket [chemical binding]; other site 485918000846 PAS domain S-box; Region: sensory_box; TIGR00229 485918000847 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918000848 putative active site [active] 485918000849 heme pocket [chemical binding]; other site 485918000850 PAS fold; Region: PAS_4; pfam08448 485918000851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918000852 dimer interface [polypeptide binding]; other site 485918000853 phosphorylation site [posttranslational modification] 485918000854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918000855 ATP binding site [chemical binding]; other site 485918000856 Mg2+ binding site [ion binding]; other site 485918000857 G-X-G motif; other site 485918000858 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 485918000859 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 485918000860 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 485918000861 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 485918000862 Interdomain contacts; other site 485918000863 Cytokine receptor motif; other site 485918000864 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 485918000865 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 485918000866 Interdomain contacts; other site 485918000867 Cytokine receptor motif; other site 485918000868 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918000869 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 485918000870 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 485918000871 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918000872 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918000873 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918000874 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918000875 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918000876 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918000877 sulfite oxidase; Provisional; Region: PLN00177 485918000878 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 485918000879 Moco binding site; other site 485918000880 metal coordination site [ion binding]; other site 485918000881 Cytochrome c; Region: Cytochrom_C; pfam00034 485918000882 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918000883 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918000884 dimer interface [polypeptide binding]; other site 485918000885 phosphorylation site [posttranslational modification] 485918000886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918000887 ATP binding site [chemical binding]; other site 485918000888 Mg2+ binding site [ion binding]; other site 485918000889 G-X-G motif; other site 485918000890 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 485918000891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918000892 active site 485918000893 phosphorylation site [posttranslational modification] 485918000894 intermolecular recognition site; other site 485918000895 dimerization interface [polypeptide binding]; other site 485918000896 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 485918000897 DNA binding site [nucleotide binding] 485918000898 Cupin-like domain; Region: Cupin_8; pfam13621 485918000899 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 485918000900 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918000901 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918000902 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 485918000903 YceI-like domain; Region: YceI; pfam04264 485918000904 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918000905 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918000906 catalytic residues [active] 485918000907 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 485918000908 active site 485918000909 Protein of unknown function (DUF3823); Region: DUF3823; pfam12866 485918000910 SusD family; Region: SusD; pfam07980 485918000911 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918000912 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918000913 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918000914 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918000915 FecR protein; Region: FecR; pfam04773 485918000916 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 485918000917 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918000918 DNA binding residues [nucleotide binding] 485918000919 Predicted transcriptional regulator [Transcription]; Region: COG2378 485918000920 HTH domain; Region: HTH_11; pfam08279 485918000921 WYL domain; Region: WYL; pfam13280 485918000922 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 485918000923 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 485918000924 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 485918000925 dimerization interface [polypeptide binding]; other site 485918000926 active site 485918000927 metal binding site [ion binding]; metal-binding site 485918000928 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 485918000929 dsRNA binding site [nucleotide binding]; other site 485918000930 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 485918000931 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 485918000932 dimer interface [polypeptide binding]; other site 485918000933 active site 485918000934 acyl carrier protein; Provisional; Region: acpP; PRK00982 485918000935 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918000936 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 485918000937 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918000938 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 485918000939 Protein export membrane protein; Region: SecD_SecF; cl14618 485918000940 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 485918000941 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918000942 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 485918000943 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK00934 485918000944 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 485918000945 active site 485918000946 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918000947 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918000948 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918000949 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918000950 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 485918000951 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918000952 YcxB-like protein; Region: YcxB; pfam14317 485918000953 geranylgeranylglyceryl phosphate synthase-like protein; Reviewed; Region: PRK04169 485918000954 PcrB family; Region: PcrB; pfam01884 485918000955 phosphate binding site [ion binding]; other site 485918000956 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 485918000957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918000958 active site 485918000959 phosphorylation site [posttranslational modification] 485918000960 intermolecular recognition site; other site 485918000961 dimerization interface [polypeptide binding]; other site 485918000962 LytTr DNA-binding domain; Region: LytTR; smart00850 485918000963 Histidine kinase; Region: His_kinase; pfam06580 485918000964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918000965 ATP binding site [chemical binding]; other site 485918000966 Mg2+ binding site [ion binding]; other site 485918000967 G-X-G motif; other site 485918000968 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 485918000969 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 485918000970 TPP-binding site; other site 485918000971 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 485918000972 PYR/PP interface [polypeptide binding]; other site 485918000973 dimer interface [polypeptide binding]; other site 485918000974 TPP binding site [chemical binding]; other site 485918000975 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 485918000976 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 485918000977 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 485918000978 FAD binding pocket [chemical binding]; other site 485918000979 FAD binding motif [chemical binding]; other site 485918000980 phosphate binding motif [ion binding]; other site 485918000981 beta-alpha-beta structure motif; other site 485918000982 NAD(p) ribose binding residues [chemical binding]; other site 485918000983 NAD binding pocket [chemical binding]; other site 485918000984 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 485918000985 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 485918000986 catalytic loop [active] 485918000987 iron binding site [ion binding]; other site 485918000988 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 485918000989 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 485918000990 dimerization interface [polypeptide binding]; other site 485918000991 DPS ferroxidase diiron center [ion binding]; other site 485918000992 ion pore; other site 485918000993 Pirin-related protein [General function prediction only]; Region: COG1741 485918000994 Pirin; Region: Pirin; pfam02678 485918000995 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 485918000996 Uncharacterized conserved protein [Function unknown]; Region: COG2353 485918000997 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918000998 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918000999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918001000 ScpA/B protein; Region: ScpA_ScpB; cl00598 485918001001 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 485918001002 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 485918001003 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 485918001004 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 485918001005 EamA-like transporter family; Region: EamA; pfam00892 485918001006 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 485918001007 EamA-like transporter family; Region: EamA; pfam00892 485918001008 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 485918001009 ribosome recycling factor; Reviewed; Region: frr; PRK00083 485918001010 hinge region; other site 485918001011 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 485918001012 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 485918001013 Mg++ binding site [ion binding]; other site 485918001014 putative catalytic motif [active] 485918001015 substrate binding site [chemical binding]; other site 485918001016 transketolase; Reviewed; Region: PRK05899 485918001017 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 485918001018 TPP-binding site [chemical binding]; other site 485918001019 dimer interface [polypeptide binding]; other site 485918001020 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 485918001021 FtsX-like permease family; Region: FtsX; pfam02687 485918001022 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 485918001023 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 485918001024 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 485918001025 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 485918001026 Walker A/P-loop; other site 485918001027 ATP binding site [chemical binding]; other site 485918001028 Q-loop/lid; other site 485918001029 ABC transporter signature motif; other site 485918001030 Walker B; other site 485918001031 D-loop; other site 485918001032 H-loop/switch region; other site 485918001033 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 485918001034 phosphoserine phosphatase SerB; Region: serB; TIGR00338 485918001035 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 485918001036 motif II; other site 485918001037 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 485918001038 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 485918001039 active site 485918001040 HIGH motif; other site 485918001041 nucleotide binding site [chemical binding]; other site 485918001042 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 485918001043 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 485918001044 active site 485918001045 KMSKS motif; other site 485918001046 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 485918001047 tRNA binding surface [nucleotide binding]; other site 485918001048 anticodon binding site; other site 485918001049 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 485918001050 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 485918001051 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918001052 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918001053 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 485918001054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918001055 ATP binding site [chemical binding]; other site 485918001056 Mg2+ binding site [ion binding]; other site 485918001057 G-X-G motif; other site 485918001058 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 485918001059 anchoring element; other site 485918001060 dimer interface [polypeptide binding]; other site 485918001061 ATP binding site [chemical binding]; other site 485918001062 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 485918001063 active site 485918001064 putative metal-binding site [ion binding]; other site 485918001065 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 485918001066 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918001067 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918001068 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918001069 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 485918001070 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918001071 Uncharacterized conserved protein [Function unknown]; Region: COG2968 485918001072 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 485918001073 legume lectins; Region: lectin_L-type; cd01951 485918001074 homotetramer interaction site [polypeptide binding]; other site 485918001075 carbohydrate binding site [chemical binding]; other site 485918001076 metal binding site [ion binding]; metal-binding site 485918001077 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918001078 FOG: PKD repeat [General function prediction only]; Region: COG3291 485918001079 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918001080 PKD domain; Region: PKD; pfam00801 485918001081 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918001082 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 485918001083 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 485918001084 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 485918001085 ATP binding site [chemical binding]; other site 485918001086 putative Mg++ binding site [ion binding]; other site 485918001087 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 485918001088 nucleotide binding region [chemical binding]; other site 485918001089 ATP-binding site [chemical binding]; other site 485918001090 TRCF domain; Region: TRCF; pfam03461 485918001091 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 485918001092 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 485918001093 FAD binding pocket [chemical binding]; other site 485918001094 conserved FAD binding motif [chemical binding]; other site 485918001095 phosphate binding motif [ion binding]; other site 485918001096 beta-alpha-beta structure motif; other site 485918001097 NAD binding pocket [chemical binding]; other site 485918001098 glycyl-tRNA synthetase; Provisional; Region: PRK04173 485918001099 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 485918001100 motif 1; other site 485918001101 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 485918001102 active site 485918001103 motif 2; other site 485918001104 motif 3; other site 485918001105 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 485918001106 anticodon binding site; other site 485918001107 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 485918001108 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 485918001109 homodimer interface [polypeptide binding]; other site 485918001110 metal binding site [ion binding]; metal-binding site 485918001111 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 485918001112 putative active site [active] 485918001113 dimerization interface [polypeptide binding]; other site 485918001114 putative tRNAtyr binding site [nucleotide binding]; other site 485918001115 hypothetical protein; Provisional; Region: PRK09256 485918001116 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 485918001117 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 485918001118 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 485918001119 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 485918001120 Surface antigen; Region: Bac_surface_Ag; pfam01103 485918001121 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 485918001122 inner membrane protein; Provisional; Region: PRK11715 485918001123 Transcriptional regulators [Transcription]; Region: MarR; COG1846 485918001124 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 485918001125 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 485918001126 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 485918001127 inhibitor-cofactor binding pocket; inhibition site 485918001128 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918001129 catalytic residue [active] 485918001130 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 485918001131 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 485918001132 trimer interface [polypeptide binding]; other site 485918001133 putative metal binding site [ion binding]; other site 485918001134 GTPase RsgA; Reviewed; Region: PRK00098 485918001135 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 485918001136 RNA binding site [nucleotide binding]; other site 485918001137 homodimer interface [polypeptide binding]; other site 485918001138 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 485918001139 GTPase/Zn-binding domain interface [polypeptide binding]; other site 485918001140 GTP/Mg2+ binding site [chemical binding]; other site 485918001141 G4 box; other site 485918001142 G5 box; other site 485918001143 G1 box; other site 485918001144 Switch I region; other site 485918001145 G2 box; other site 485918001146 G3 box; other site 485918001147 Switch II region; other site 485918001148 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 485918001149 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 485918001150 metal ion-dependent adhesion site (MIDAS); other site 485918001151 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 485918001152 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 485918001153 metal ion-dependent adhesion site (MIDAS); other site 485918001154 MoxR-like ATPases [General function prediction only]; Region: COG0714 485918001155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918001156 Walker A motif; other site 485918001157 ATP binding site [chemical binding]; other site 485918001158 Walker B motif; other site 485918001159 arginine finger; other site 485918001160 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 485918001161 active site 485918001162 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 485918001163 lipoyl attachment site [posttranslational modification]; other site 485918001164 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 485918001165 Cation efflux family; Region: Cation_efflux; pfam01545 485918001166 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 485918001167 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 485918001168 ligand binding site [chemical binding]; other site 485918001169 peptide chain release factor 1; Validated; Region: prfA; PRK00591 485918001170 This domain is found in peptide chain release factors; Region: PCRF; smart00937 485918001171 RF-1 domain; Region: RF-1; pfam00472 485918001172 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 485918001173 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 485918001174 Amidohydrolase; Region: Amidohydro_4; pfam13147 485918001175 active site 485918001176 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 485918001177 Mechanosensitive ion channel; Region: MS_channel; pfam00924 485918001178 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 485918001179 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 485918001180 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 485918001181 DNA binding residues [nucleotide binding] 485918001182 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 485918001183 Peptidase family M23; Region: Peptidase_M23; pfam01551 485918001184 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 485918001185 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 485918001186 motif 1; other site 485918001187 active site 485918001188 motif 2; other site 485918001189 motif 3; other site 485918001190 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 485918001191 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 485918001192 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 485918001193 protein binding site [polypeptide binding]; other site 485918001194 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 485918001195 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 485918001196 NAD(P) binding site [chemical binding]; other site 485918001197 catalytic residues [active] 485918001198 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 485918001199 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 485918001200 GatB domain; Region: GatB_Yqey; smart00845 485918001201 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 485918001202 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918001203 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918001204 catalytic residues [active] 485918001205 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918001206 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918001207 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918001208 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918001209 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918001210 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918001211 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918001212 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918001213 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918001214 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918001215 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 485918001216 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918001217 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918001218 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918001219 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918001220 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918001221 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 485918001222 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918001223 DNA binding residues [nucleotide binding] 485918001224 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 485918001225 Protein export membrane protein; Region: SecD_SecF; cl14618 485918001226 Two component regulator propeller; Region: Reg_prop; pfam07494 485918001227 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918001228 Recombination protein O N terminal; Region: RecO_N; pfam11967 485918001229 Recombination protein O C terminal; Region: RecO_C; pfam02565 485918001230 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 485918001231 putative active site [active] 485918001232 putative metal binding site [ion binding]; other site 485918001233 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 485918001234 FtsH Extracellular; Region: FtsH_ext; pfam06480 485918001235 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 485918001236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918001237 Walker A motif; other site 485918001238 ATP binding site [chemical binding]; other site 485918001239 Walker B motif; other site 485918001240 arginine finger; other site 485918001241 Peptidase family M41; Region: Peptidase_M41; pfam01434 485918001242 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 485918001243 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 485918001244 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 485918001245 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 485918001246 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918001247 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918001248 translation initiation factor Sui1; Validated; Region: PRK06824 485918001249 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 485918001250 putative rRNA binding site [nucleotide binding]; other site 485918001251 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 485918001252 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 485918001253 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 485918001254 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 485918001255 dimerization interface [polypeptide binding]; other site 485918001256 active site 485918001257 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 485918001258 phosphoglyceromutase; Provisional; Region: PRK05434 485918001259 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 485918001260 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 485918001261 GIY-YIG motif/motif A; other site 485918001262 active site 485918001263 catalytic site [active] 485918001264 putative DNA binding site [nucleotide binding]; other site 485918001265 metal binding site [ion binding]; metal-binding site 485918001266 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 485918001267 DinB superfamily; Region: DinB_2; pfam12867 485918001268 gliding motility associated protien GldN; Region: GldN; TIGR03523 485918001269 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 485918001270 GldM N-terminal domain; Region: GldM_N; pfam12081 485918001271 GldM C-terminal domain; Region: GldM_C; pfam12080 485918001272 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 485918001273 gliding motility-associated lipoprotein GldK; Region: GldK; TIGR03525 485918001274 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 485918001275 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 485918001276 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 485918001277 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 485918001278 catalytic residues [active] 485918001279 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 485918001280 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 485918001281 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 485918001282 active site 485918001283 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 485918001284 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 485918001285 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 485918001286 FeS/SAM binding site; other site 485918001287 HemN C-terminal domain; Region: HemN_C; pfam06969 485918001288 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 485918001289 active site 485918001290 catalytic residues [active] 485918001291 deoxyhypusine synthase; Region: dhys; TIGR00321 485918001292 Deoxyhypusine synthase; Region: DS; cl00826 485918001293 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 485918001294 Protein of unknown function, DUF479; Region: DUF479; cl01203 485918001295 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 485918001296 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 485918001297 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 485918001298 homodimer interface [polypeptide binding]; other site 485918001299 substrate-cofactor binding pocket; other site 485918001300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918001301 catalytic residue [active] 485918001302 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 485918001303 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 485918001304 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 485918001305 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 485918001306 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 485918001307 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 485918001308 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 485918001309 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 485918001310 Ligand Binding Site [chemical binding]; other site 485918001311 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 485918001312 Ligand Binding Site [chemical binding]; other site 485918001313 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 485918001314 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 485918001315 dimer interface [polypeptide binding]; other site 485918001316 putative anticodon binding site; other site 485918001317 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 485918001318 motif 1; other site 485918001319 active site 485918001320 motif 2; other site 485918001321 motif 3; other site 485918001322 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 485918001323 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 485918001324 Clathrin light chain; Region: Clathrin_lg_ch; pfam01086 485918001325 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918001326 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 485918001327 dimer interface [polypeptide binding]; other site 485918001328 putative tRNA-binding site [nucleotide binding]; other site 485918001329 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 485918001330 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 485918001331 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 485918001332 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 485918001333 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 485918001334 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 485918001335 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 485918001336 membrane ATPase/protein kinase; Provisional; Region: PRK09435 485918001337 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 485918001338 Walker A; other site 485918001339 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 485918001340 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 485918001341 Cl- selectivity filter; other site 485918001342 Cl- binding residues [ion binding]; other site 485918001343 pore gating glutamate residue; other site 485918001344 dimer interface [polypeptide binding]; other site 485918001345 Domain of unknown function (DUF2024); Region: DUF2024; pfam09630 485918001346 Protein of unknown function (DUF420); Region: DUF420; pfam04238 485918001347 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 485918001348 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 485918001349 Cu(I) binding site [ion binding]; other site 485918001350 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 485918001351 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 485918001352 Subunit I/III interface [polypeptide binding]; other site 485918001353 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 485918001354 Subunit I/III interface [polypeptide binding]; other site 485918001355 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 485918001356 UbiA prenyltransferase family; Region: UbiA; pfam01040 485918001357 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 485918001358 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 485918001359 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 485918001360 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 485918001361 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 485918001362 cytochrome c-550; Provisional; Region: psbV; cl17239 485918001363 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 485918001364 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 485918001365 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 485918001366 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 485918001367 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 485918001368 molybdopterin cofactor binding site; other site 485918001369 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 485918001370 molybdopterin cofactor binding site; other site 485918001371 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 485918001372 4Fe-4S binding domain; Region: Fer4; cl02805 485918001373 Cytochrome c; Region: Cytochrom_C; pfam00034 485918001374 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 485918001375 heme-binding residues [chemical binding]; other site 485918001376 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 485918001377 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 485918001378 active site 485918001379 substrate binding site [chemical binding]; other site 485918001380 cosubstrate binding site; other site 485918001381 catalytic site [active] 485918001382 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 485918001383 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 485918001384 Cu(I) binding site [ion binding]; other site 485918001385 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 485918001386 metal binding site 2 [ion binding]; metal-binding site 485918001387 putative DNA binding helix; other site 485918001388 metal binding site 1 [ion binding]; metal-binding site 485918001389 dimer interface [polypeptide binding]; other site 485918001390 structural Zn2+ binding site [ion binding]; other site 485918001391 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 485918001392 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 485918001393 active site 485918001394 Zn binding site [ion binding]; other site 485918001395 Lamin Tail Domain; Region: LTD; pfam00932 485918001396 Lamin Tail Domain; Region: LTD; pfam00932 485918001397 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 485918001398 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 485918001399 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 485918001400 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 485918001401 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 485918001402 excinuclease ABC subunit B; Provisional; Region: PRK05298 485918001403 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 485918001404 ATP binding site [chemical binding]; other site 485918001405 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 485918001406 nucleotide binding region [chemical binding]; other site 485918001407 ATP-binding site [chemical binding]; other site 485918001408 Ultra-violet resistance protein B; Region: UvrB; pfam12344 485918001409 UvrB/uvrC motif; Region: UVR; pfam02151 485918001410 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 485918001411 active site 485918001412 Zn binding site [ion binding]; other site 485918001413 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 485918001414 substrate binding site [chemical binding]; other site 485918001415 ATP binding site [chemical binding]; other site 485918001416 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 485918001417 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_14; cd13139 485918001418 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 485918001419 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918001420 binding surface 485918001421 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918001422 TPR motif; other site 485918001423 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918001424 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 485918001425 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 485918001426 ligand binding site [chemical binding]; other site 485918001427 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 485918001428 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918001429 NACHT domain; Region: NACHT; pfam05729 485918001430 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 485918001431 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 485918001432 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 485918001433 Cl- selectivity filter; other site 485918001434 Cl- binding residues [ion binding]; other site 485918001435 pore gating glutamate residue; other site 485918001436 dimer interface [polypeptide binding]; other site 485918001437 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 485918001438 FOG: CBS domain [General function prediction only]; Region: COG0517 485918001439 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 485918001440 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 485918001441 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 485918001442 TrkA-N domain; Region: TrkA_N; pfam02254 485918001443 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 485918001444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918001445 putative substrate translocation pore; other site 485918001446 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 485918001447 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 485918001448 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918001449 Outer membrane efflux protein; Region: OEP; pfam02321 485918001450 Outer membrane efflux protein; Region: OEP; pfam02321 485918001451 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918001452 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918001453 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 485918001454 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 485918001455 putative substrate binding site [chemical binding]; other site 485918001456 putative ATP binding site [chemical binding]; other site 485918001457 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 485918001458 putative ligand binding site [chemical binding]; other site 485918001459 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 485918001460 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 485918001461 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918001462 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918001463 SusD family; Region: SusD; pfam07980 485918001464 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918001465 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918001466 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918001467 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918001468 WYL domain; Region: WYL; pfam13280 485918001469 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 485918001470 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 485918001471 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 485918001472 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 485918001473 Protein of unknown function (DUF458); Region: DUF458; cl00861 485918001474 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918001475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918001476 active site 485918001477 phosphorylation site [posttranslational modification] 485918001478 intermolecular recognition site; other site 485918001479 dimerization interface [polypeptide binding]; other site 485918001480 LytTr DNA-binding domain; Region: LytTR; smart00850 485918001481 CHASE3 domain; Region: CHASE3; cl05000 485918001482 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918001483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918001484 dimer interface [polypeptide binding]; other site 485918001485 phosphorylation site [posttranslational modification] 485918001486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918001487 ATP binding site [chemical binding]; other site 485918001488 Mg2+ binding site [ion binding]; other site 485918001489 G-X-G motif; other site 485918001490 Response regulator receiver domain; Region: Response_reg; pfam00072 485918001491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918001492 active site 485918001493 phosphorylation site [posttranslational modification] 485918001494 intermolecular recognition site; other site 485918001495 dimerization interface [polypeptide binding]; other site 485918001496 Hpt domain; Region: Hpt; pfam01627 485918001497 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 485918001498 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 485918001499 catalytic residues [active] 485918001500 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918001501 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918001502 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918001503 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 485918001504 DoxX-like family; Region: DoxX_2; pfam13564 485918001505 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 485918001506 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 485918001507 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 485918001508 PLD-like domain; Region: PLDc_2; pfam13091 485918001509 homodimer interface [polypeptide binding]; other site 485918001510 putative active site [active] 485918001511 catalytic site [active] 485918001512 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 485918001513 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 485918001514 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 485918001515 iron-sulfur cluster [ion binding]; other site 485918001516 [2Fe-2S] cluster binding site [ion binding]; other site 485918001517 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 485918001518 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 485918001519 HflX GTPase family; Region: HflX; cd01878 485918001520 G1 box; other site 485918001521 GTP/Mg2+ binding site [chemical binding]; other site 485918001522 Switch I region; other site 485918001523 G2 box; other site 485918001524 G3 box; other site 485918001525 Switch II region; other site 485918001526 G4 box; other site 485918001527 G5 box; other site 485918001528 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 485918001529 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918001530 enoyl-CoA hydratase; Provisional; Region: PRK08140 485918001531 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 485918001532 substrate binding site [chemical binding]; other site 485918001533 oxyanion hole (OAH) forming residues; other site 485918001534 trimer interface [polypeptide binding]; other site 485918001535 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 485918001536 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918001537 TPR motif; other site 485918001538 binding surface 485918001539 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 485918001540 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 485918001541 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 485918001542 ATP binding site [chemical binding]; other site 485918001543 putative Mg++ binding site [ion binding]; other site 485918001544 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 485918001545 nucleotide binding region [chemical binding]; other site 485918001546 ATP-binding site [chemical binding]; other site 485918001547 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 485918001548 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 485918001549 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 485918001550 putative hydrophobic ligand binding site [chemical binding]; other site 485918001551 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 485918001552 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 485918001553 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 485918001554 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 485918001555 PA/protease or protease-like domain interface [polypeptide binding]; other site 485918001556 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 485918001557 Peptidase family M28; Region: Peptidase_M28; pfam04389 485918001558 metal binding site [ion binding]; metal-binding site 485918001559 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 485918001560 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 485918001561 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 485918001562 nudix motif; other site 485918001563 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 485918001564 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 485918001565 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918001566 FtsX-like permease family; Region: FtsX; pfam02687 485918001567 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918001568 FtsX-like permease family; Region: FtsX; pfam02687 485918001569 short chain dehydrogenase; Validated; Region: PRK06182 485918001570 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918001571 NADP binding site [chemical binding]; other site 485918001572 active site 485918001573 steroid binding site; other site 485918001574 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918001575 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918001576 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 485918001577 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 485918001578 active site 485918001579 nucleotide binding site [chemical binding]; other site 485918001580 HIGH motif; other site 485918001581 KMSKS motif; other site 485918001582 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 485918001583 nudix motif; other site 485918001584 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 485918001585 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 485918001586 active site 485918001587 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 485918001588 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918001589 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 485918001590 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918001591 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 485918001592 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918001593 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918001594 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918001595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918001596 aspartate aminotransferase; Provisional; Region: PRK05764 485918001597 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 485918001598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918001599 homodimer interface [polypeptide binding]; other site 485918001600 catalytic residue [active] 485918001601 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 485918001602 DNA polymerase III subunit beta; Validated; Region: PRK05643 485918001603 putative DNA binding surface [nucleotide binding]; other site 485918001604 dimer interface [polypeptide binding]; other site 485918001605 beta-clamp/translesion DNA polymerase binding surface; other site 485918001606 beta-clamp/clamp loader binding surface; other site 485918001607 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 485918001608 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 485918001609 Lipocalin-like; Region: Lipocalin_3; pfam12702 485918001610 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 485918001611 thiS-thiF/thiG interaction site; other site 485918001612 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 485918001613 ThiC-associated domain; Region: ThiC-associated; pfam13667 485918001614 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 485918001615 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 485918001616 thiamine phosphate binding site [chemical binding]; other site 485918001617 active site 485918001618 pyrophosphate binding site [ion binding]; other site 485918001619 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 485918001620 substrate binding site [chemical binding]; other site 485918001621 dimer interface [polypeptide binding]; other site 485918001622 ATP binding site [chemical binding]; other site 485918001623 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 485918001624 thiamine phosphate binding site [chemical binding]; other site 485918001625 active site 485918001626 pyrophosphate binding site [ion binding]; other site 485918001627 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 485918001628 ThiS interaction site; other site 485918001629 putative active site [active] 485918001630 tetramer interface [polypeptide binding]; other site 485918001631 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 485918001632 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 485918001633 FeS/SAM binding site; other site 485918001634 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 485918001635 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 485918001636 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 485918001637 dinuclear metal binding motif [ion binding]; other site 485918001638 Ferritin-like domain; Region: Ferritin_2; pfam13668 485918001639 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 485918001640 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918001641 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918001642 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918001643 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918001644 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918001645 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918001646 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 485918001647 active site 485918001648 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 485918001649 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 485918001650 TMP-binding site; other site 485918001651 ATP-binding site [chemical binding]; other site 485918001652 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918001653 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 485918001654 Peptidase family M1; Region: Peptidase_M1; pfam01433 485918001655 Zn binding site [ion binding]; other site 485918001656 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918001657 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918001658 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918001659 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918001660 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 485918001661 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 485918001662 NADP binding site [chemical binding]; other site 485918001663 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 485918001664 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 485918001665 cofactor binding site; other site 485918001666 DNA binding site [nucleotide binding] 485918001667 substrate interaction site [chemical binding]; other site 485918001668 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 485918001669 salt bridge; other site 485918001670 non-specific DNA binding site [nucleotide binding]; other site 485918001671 sequence-specific DNA binding site [nucleotide binding]; other site 485918001672 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 485918001673 active site 485918001674 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 485918001675 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 485918001676 TM2 domain; Region: TM2; pfam05154 485918001677 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 485918001678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 485918001679 Sm and related proteins; Region: Sm_like; cl00259 485918001680 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 485918001681 putative oligomer interface [polypeptide binding]; other site 485918001682 putative RNA binding site [nucleotide binding]; other site 485918001683 transcription termination factor NusA; Region: NusA; TIGR01953 485918001684 NusA N-terminal domain; Region: NusA_N; pfam08529 485918001685 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 485918001686 RNA binding site [nucleotide binding]; other site 485918001687 homodimer interface [polypeptide binding]; other site 485918001688 NusA-like KH domain; Region: KH_5; pfam13184 485918001689 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 485918001690 G-X-X-G motif; other site 485918001691 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 485918001692 translation initiation factor IF-2; Region: IF-2; TIGR00487 485918001693 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 485918001694 G1 box; other site 485918001695 putative GEF interaction site [polypeptide binding]; other site 485918001696 GTP/Mg2+ binding site [chemical binding]; other site 485918001697 Switch I region; other site 485918001698 G2 box; other site 485918001699 G3 box; other site 485918001700 Switch II region; other site 485918001701 G4 box; other site 485918001702 G5 box; other site 485918001703 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 485918001704 Translation-initiation factor 2; Region: IF-2; pfam11987 485918001705 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 485918001706 SurA N-terminal domain; Region: SurA_N; pfam09312 485918001707 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 485918001708 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 485918001709 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 485918001710 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 485918001711 active site 485918001712 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 485918001713 active site 485918001714 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 485918001715 catalytic core [active] 485918001716 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 485918001717 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 485918001718 Staphylococcal nuclease homologues; Region: SNc; smart00318 485918001719 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 485918001720 Catalytic site; other site 485918001721 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 485918001722 AAA domain; Region: AAA_30; pfam13604 485918001723 AAA domain; Region: AAA_11; pfam13086 485918001724 AAA domain; Region: AAA_12; pfam13087 485918001725 HNH endonuclease; Region: HNH_3; pfam13392 485918001726 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 485918001727 DNA-binding interface [nucleotide binding]; DNA binding site 485918001728 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 485918001729 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 485918001730 FMN binding site [chemical binding]; other site 485918001731 active site 485918001732 catalytic residues [active] 485918001733 substrate binding site [chemical binding]; other site 485918001734 CAAX protease self-immunity; Region: Abi; pfam02517 485918001735 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 485918001736 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 485918001737 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 485918001738 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 485918001739 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 485918001740 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 485918001741 motif II; other site 485918001742 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 485918001743 classical (c) SDRs; Region: SDR_c; cd05233 485918001744 NAD(P) binding site [chemical binding]; other site 485918001745 active site 485918001746 Oxygen tolerance; Region: BatD; pfam13584 485918001747 TPR repeat; Region: TPR_11; pfam13414 485918001748 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918001749 binding surface 485918001750 TPR motif; other site 485918001751 Bacterial SH3 domain; Region: SH3_3; cl17532 485918001752 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918001753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918001754 active site 485918001755 phosphorylation site [posttranslational modification] 485918001756 intermolecular recognition site; other site 485918001757 dimerization interface [polypeptide binding]; other site 485918001758 LytTr DNA-binding domain; Region: LytTR; pfam04397 485918001759 Histidine kinase; Region: His_kinase; pfam06580 485918001760 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 485918001761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918001762 active site 485918001763 phosphorylation site [posttranslational modification] 485918001764 intermolecular recognition site; other site 485918001765 dimerization interface [polypeptide binding]; other site 485918001766 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 485918001767 DNA binding site [nucleotide binding] 485918001768 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 485918001769 dimer interface [polypeptide binding]; other site 485918001770 phosphorylation site [posttranslational modification] 485918001771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918001772 ATP binding site [chemical binding]; other site 485918001773 Mg2+ binding site [ion binding]; other site 485918001774 G-X-G motif; other site 485918001775 GldH lipoprotein; Region: GldH_lipo; pfam14109 485918001776 hypothetical protein; Provisional; Region: PRK11820 485918001777 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 485918001778 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 485918001779 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 485918001780 pseudouridine synthase; Region: TIGR00093 485918001781 active site 485918001782 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918001783 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 485918001784 ligand binding site [chemical binding]; other site 485918001785 flexible hinge region; other site 485918001786 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 485918001787 putative switch regulator; other site 485918001788 non-specific DNA interactions [nucleotide binding]; other site 485918001789 DNA binding site [nucleotide binding] 485918001790 sequence specific DNA binding site [nucleotide binding]; other site 485918001791 putative cAMP binding site [chemical binding]; other site 485918001792 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 485918001793 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 485918001794 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 485918001795 metal-binding site [ion binding] 485918001796 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 485918001797 Soluble P-type ATPase [General function prediction only]; Region: COG4087 485918001798 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 485918001799 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 485918001800 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 485918001801 Low-spin heme binding site [chemical binding]; other site 485918001802 Putative water exit pathway; other site 485918001803 Binuclear center (active site) [active] 485918001804 Putative proton exit pathway; other site 485918001805 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 485918001806 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 485918001807 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 485918001808 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 485918001809 4Fe-4S binding domain; Region: Fer4_5; pfam12801 485918001810 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 485918001811 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 485918001812 FixH; Region: FixH; pfam05751 485918001813 Family description; Region: DsbD_2; pfam13386 485918001814 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 485918001815 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 485918001816 FeS/SAM binding site; other site 485918001817 HemN C-terminal domain; Region: HemN_C; pfam06969 485918001818 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 485918001819 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 485918001820 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 485918001821 trimer interface [polypeptide binding]; other site 485918001822 active site 485918001823 UDP-GlcNAc binding site [chemical binding]; other site 485918001824 lipid binding site [chemical binding]; lipid-binding site 485918001825 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 485918001826 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 485918001827 putative NADP binding site [chemical binding]; other site 485918001828 putative substrate binding site [chemical binding]; other site 485918001829 active site 485918001830 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 485918001831 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 485918001832 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 485918001833 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 485918001834 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 485918001835 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 485918001836 dimer interface [polypeptide binding]; other site 485918001837 motif 1; other site 485918001838 active site 485918001839 motif 2; other site 485918001840 motif 3; other site 485918001841 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 485918001842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918001843 active site 485918001844 phosphorylation site [posttranslational modification] 485918001845 intermolecular recognition site; other site 485918001846 dimerization interface [polypeptide binding]; other site 485918001847 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 485918001848 DNA binding site [nucleotide binding] 485918001849 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918001850 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918001851 dimer interface [polypeptide binding]; other site 485918001852 phosphorylation site [posttranslational modification] 485918001853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918001854 ATP binding site [chemical binding]; other site 485918001855 Mg2+ binding site [ion binding]; other site 485918001856 G-X-G motif; other site 485918001857 Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903 485918001858 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918001859 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918001860 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 485918001861 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 485918001862 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 485918001863 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 485918001864 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 485918001865 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 485918001866 catalytic motif [active] 485918001867 Catalytic residue [active] 485918001868 Aspartyl protease; Region: Asp_protease_2; pfam13650 485918001869 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 485918001870 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 485918001871 catalytic motif [active] 485918001872 Catalytic residue [active] 485918001873 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 485918001874 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 485918001875 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 485918001876 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 485918001877 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 485918001878 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 485918001879 Uncharacterized conserved protein [Function unknown]; Region: COG1284 485918001880 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 485918001881 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 485918001882 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 485918001883 putative active site [active] 485918001884 putative metal binding site [ion binding]; other site 485918001885 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 485918001886 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 485918001887 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 485918001888 ArsC family; Region: ArsC; pfam03960 485918001889 catalytic residue [active] 485918001890 DNA polymerase I; Provisional; Region: PRK05755 485918001891 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 485918001892 active site 485918001893 metal binding site 1 [ion binding]; metal-binding site 485918001894 putative 5' ssDNA interaction site; other site 485918001895 metal binding site 3; metal-binding site 485918001896 metal binding site 2 [ion binding]; metal-binding site 485918001897 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 485918001898 putative DNA binding site [nucleotide binding]; other site 485918001899 putative metal binding site [ion binding]; other site 485918001900 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 485918001901 active site 485918001902 catalytic site [active] 485918001903 substrate binding site [chemical binding]; other site 485918001904 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 485918001905 active site 485918001906 DNA binding site [nucleotide binding] 485918001907 catalytic site [active] 485918001908 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 485918001909 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 485918001910 Coenzyme A binding pocket [chemical binding]; other site 485918001911 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 485918001912 active site 485918001913 Pectate lyase; Region: Pectate_lyase; pfam03211 485918001914 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 485918001915 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 485918001916 Transglycosylase; Region: Transgly; cl17702 485918001917 AAA domain; Region: AAA_28; pfam13521 485918001918 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 485918001919 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 485918001920 Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903 485918001921 Peptide-N-glycosidase F, N terminal; Region: N-glycanase_N; pfam09112 485918001922 Peptide-N-glycosidase F, C terminal; Region: N-glycanase_C; pfam09113 485918001923 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 485918001924 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 485918001925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 485918001926 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 485918001927 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 485918001928 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 485918001929 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 485918001930 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 485918001931 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 485918001932 active site 485918001933 catalytic site [active] 485918001934 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 485918001935 amphipathic channel; other site 485918001936 Asn-Pro-Ala signature motifs; other site 485918001937 glycerol kinase; Provisional; Region: glpK; PRK00047 485918001938 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 485918001939 N- and C-terminal domain interface [polypeptide binding]; other site 485918001940 active site 485918001941 MgATP binding site [chemical binding]; other site 485918001942 catalytic site [active] 485918001943 metal binding site [ion binding]; metal-binding site 485918001944 glycerol binding site [chemical binding]; other site 485918001945 homotetramer interface [polypeptide binding]; other site 485918001946 homodimer interface [polypeptide binding]; other site 485918001947 FBP binding site [chemical binding]; other site 485918001948 protein IIAGlc interface [polypeptide binding]; other site 485918001949 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 485918001950 hydroxyglutarate oxidase; Provisional; Region: PRK11728 485918001951 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 485918001952 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 485918001953 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 485918001954 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 485918001955 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 485918001956 active site 485918001957 dimer interface [polypeptide binding]; other site 485918001958 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 485918001959 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 485918001960 active site 485918001961 FMN binding site [chemical binding]; other site 485918001962 substrate binding site [chemical binding]; other site 485918001963 3Fe-4S cluster binding site [ion binding]; other site 485918001964 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 485918001965 domain interface; other site 485918001966 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 485918001967 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 485918001968 Family of unknown function (DUF490); Region: DUF490; pfam04357 485918001969 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 485918001970 Surface antigen; Region: Bac_surface_Ag; pfam01103 485918001971 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 485918001972 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 485918001973 intracellular protease, PfpI family; Region: PfpI; TIGR01382 485918001974 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 485918001975 proposed catalytic triad [active] 485918001976 conserved cys residue [active] 485918001977 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 485918001978 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 485918001979 oligomer interface [polypeptide binding]; other site 485918001980 metal binding site [ion binding]; metal-binding site 485918001981 metal binding site [ion binding]; metal-binding site 485918001982 Cl binding site [ion binding]; other site 485918001983 aspartate ring; other site 485918001984 basic sphincter; other site 485918001985 putative hydrophobic gate; other site 485918001986 periplasmic entrance; other site 485918001987 Protein of unknown function (DUF2480); Region: DUF2480; pfam10652 485918001988 SurA N-terminal domain; Region: SurA_N_3; cl07813 485918001989 periplasmic folding chaperone; Provisional; Region: PRK10788 485918001990 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 485918001991 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 485918001992 quinolinate synthetase; Provisional; Region: PRK09375 485918001993 FeoA domain; Region: FeoA; pfam04023 485918001994 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 485918001995 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 485918001996 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 485918001997 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 485918001998 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 485918001999 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 485918002000 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 485918002001 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 485918002002 putative active site [active] 485918002003 catalytic site [active] 485918002004 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 485918002005 putative active site [active] 485918002006 catalytic site [active] 485918002007 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 485918002008 Part of AAA domain; Region: AAA_19; pfam13245 485918002009 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 485918002010 AAA domain; Region: AAA_12; pfam13087 485918002011 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 485918002012 putative active site [active] 485918002013 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 485918002014 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 485918002015 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 485918002016 metal ion-dependent adhesion site (MIDAS); other site 485918002017 MoxR-like ATPases [General function prediction only]; Region: COG0714 485918002018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918002019 Walker A motif; other site 485918002020 ATP binding site [chemical binding]; other site 485918002021 Walker B motif; other site 485918002022 arginine finger; other site 485918002023 SWIM zinc finger; Region: SWIM; pfam04434 485918002024 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 485918002025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918002026 putative substrate translocation pore; other site 485918002027 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 485918002028 tetramer (dimer of dimers) interface [polypeptide binding]; other site 485918002029 active site 485918002030 dimer interface [polypeptide binding]; other site 485918002031 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 485918002032 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 485918002033 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 485918002034 active site residue [active] 485918002035 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 485918002036 active site residue [active] 485918002037 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 485918002038 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 485918002039 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 485918002040 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 485918002041 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918002042 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918002043 putative transposase OrfB; Reviewed; Region: PHA02517 485918002044 HTH-like domain; Region: HTH_21; pfam13276 485918002045 Integrase core domain; Region: rve; pfam00665 485918002046 Integrase core domain; Region: rve_3; pfam13683 485918002047 Transposase; Region: HTH_Tnp_1; pfam01527 485918002048 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 485918002049 Protein of unknown function, DUF488; Region: DUF488; pfam04343 485918002050 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 485918002051 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 485918002052 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 485918002053 ATP binding site [chemical binding]; other site 485918002054 putative Mg++ binding site [ion binding]; other site 485918002055 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 485918002056 nucleotide binding region [chemical binding]; other site 485918002057 ATP-binding site [chemical binding]; other site 485918002058 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 485918002059 HRDC domain; Region: HRDC; pfam00570 485918002060 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 485918002061 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 485918002062 putative active site [active] 485918002063 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 485918002064 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 485918002065 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 485918002066 Substrate binding site; other site 485918002067 Cupin domain; Region: Cupin_2; cl17218 485918002068 methionine aminotransferase; Validated; Region: PRK09082 485918002069 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 485918002070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918002071 homodimer interface [polypeptide binding]; other site 485918002072 catalytic residue [active] 485918002073 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 485918002074 active site clefts [active] 485918002075 zinc binding site [ion binding]; other site 485918002076 dimer interface [polypeptide binding]; other site 485918002077 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 485918002078 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 485918002079 Sulfate transporter family; Region: Sulfate_transp; pfam00916 485918002080 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 485918002081 Predicted transcriptional regulators [Transcription]; Region: COG1695 485918002082 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 485918002083 PspC domain; Region: PspC; pfam04024 485918002084 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 485918002085 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 485918002086 G1 box; other site 485918002087 GTP/Mg2+ binding site [chemical binding]; other site 485918002088 Switch I region; other site 485918002089 G2 box; other site 485918002090 G3 box; other site 485918002091 Switch II region; other site 485918002092 G4 box; other site 485918002093 G5 box; other site 485918002094 Nucleoside recognition; Region: Gate; pfam07670 485918002095 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 485918002096 Nucleoside recognition; Region: Gate; pfam07670 485918002097 M28 Zn-Peptidases; Region: M28_like_2; cd05662 485918002098 Peptidase family M28; Region: Peptidase_M28; pfam04389 485918002099 metal binding site [ion binding]; metal-binding site 485918002100 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 485918002101 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 485918002102 Phenylacetic acid degradation B; Region: PaaB; pfam06243 485918002103 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 485918002104 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 485918002105 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 485918002106 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 485918002107 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 485918002108 active site 485918002109 (T/H)XGH motif; other site 485918002110 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 485918002111 Domain of unknown function DUF20; Region: UPF0118; pfam01594 485918002112 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 485918002113 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 485918002114 FeS/SAM binding site; other site 485918002115 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 485918002116 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 485918002117 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 485918002118 active site 485918002119 Elongation factor TS; Region: EF_TS; pfam00889 485918002120 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 485918002121 SnoaL-like domain; Region: SnoaL_3; pfam13474 485918002122 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 485918002123 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 485918002124 inhibitor-cofactor binding pocket; inhibition site 485918002125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918002126 catalytic residue [active] 485918002127 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 485918002128 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 485918002129 Ligand binding site; other site 485918002130 oligomer interface; other site 485918002131 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 485918002132 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 485918002133 active site 485918002134 NAD binding site [chemical binding]; other site 485918002135 metal binding site [ion binding]; metal-binding site 485918002136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918002137 Major Facilitator Superfamily; Region: MFS_1; pfam07690 485918002138 putative substrate translocation pore; other site 485918002139 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 485918002140 putative metal binding site [ion binding]; other site 485918002141 Uncharacterized conserved protein [Function unknown]; Region: COG1432 485918002142 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 485918002143 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 485918002144 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 485918002145 TPP-binding site [chemical binding]; other site 485918002146 tetramer interface [polypeptide binding]; other site 485918002147 heterodimer interface [polypeptide binding]; other site 485918002148 phosphorylation loop region [posttranslational modification] 485918002149 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 485918002150 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 485918002151 alpha subunit interface [polypeptide binding]; other site 485918002152 TPP binding site [chemical binding]; other site 485918002153 heterodimer interface [polypeptide binding]; other site 485918002154 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 485918002155 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 485918002156 Uncharacterized conserved protein [Function unknown]; Region: COG1262 485918002157 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 485918002158 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 485918002159 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 485918002160 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 485918002161 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 485918002162 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 485918002163 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 485918002164 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 485918002165 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 485918002166 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 485918002167 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 485918002168 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 485918002169 N- and C-terminal domain interface [polypeptide binding]; other site 485918002170 active site 485918002171 catalytic site [active] 485918002172 metal binding site [ion binding]; metal-binding site 485918002173 carbohydrate binding site [chemical binding]; other site 485918002174 ATP binding site [chemical binding]; other site 485918002175 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 485918002176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918002177 ATP binding site [chemical binding]; other site 485918002178 Mg2+ binding site [ion binding]; other site 485918002179 G-X-G motif; other site 485918002180 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 485918002181 ATP binding site [chemical binding]; other site 485918002182 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 485918002183 methionine sulfoxide reductase B; Provisional; Region: PRK00222 485918002184 SelR domain; Region: SelR; pfam01641 485918002185 YCII-related domain; Region: YCII; cl00999 485918002186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918002187 Walker A/P-loop; other site 485918002188 ATP binding site [chemical binding]; other site 485918002189 ABC transporter; Region: ABC_tran; pfam00005 485918002190 Q-loop/lid; other site 485918002191 ABC transporter signature motif; other site 485918002192 Walker B; other site 485918002193 D-loop; other site 485918002194 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 485918002195 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 485918002196 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 485918002197 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 485918002198 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 485918002199 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 485918002200 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 485918002201 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 485918002202 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918002203 binding surface 485918002204 TPR motif; other site 485918002205 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 485918002206 GTPase CgtA; Reviewed; Region: obgE; PRK12299 485918002207 GTP1/OBG; Region: GTP1_OBG; pfam01018 485918002208 Obg GTPase; Region: Obg; cd01898 485918002209 G1 box; other site 485918002210 GTP/Mg2+ binding site [chemical binding]; other site 485918002211 Switch I region; other site 485918002212 G2 box; other site 485918002213 G3 box; other site 485918002214 Switch II region; other site 485918002215 G4 box; other site 485918002216 G5 box; other site 485918002217 adenylate kinase; Reviewed; Region: adk; PRK00279 485918002218 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 485918002219 AMP-binding site [chemical binding]; other site 485918002220 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 485918002221 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 485918002222 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 485918002223 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 485918002224 Beta-lactamase; Region: Beta-lactamase; cl17358 485918002225 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 485918002226 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 485918002227 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 485918002228 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 485918002229 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918002230 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 485918002231 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 485918002232 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 485918002233 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 485918002234 G1 box; other site 485918002235 putative GEF interaction site [polypeptide binding]; other site 485918002236 GTP/Mg2+ binding site [chemical binding]; other site 485918002237 Switch I region; other site 485918002238 G2 box; other site 485918002239 G3 box; other site 485918002240 Switch II region; other site 485918002241 G4 box; other site 485918002242 G5 box; other site 485918002243 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 485918002244 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 485918002245 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 485918002246 META domain; Region: META; pfam03724 485918002247 IPT/TIG domain; Region: TIG; pfam01833 485918002248 Peptidase S46; Region: Peptidase_S46; pfam10459 485918002249 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 485918002250 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 485918002251 RNA/DNA hybrid binding site [nucleotide binding]; other site 485918002252 active site 485918002253 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 485918002254 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 485918002255 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 485918002256 recombinase A; Provisional; Region: recA; PRK09354 485918002257 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 485918002258 hexamer interface [polypeptide binding]; other site 485918002259 Walker A motif; other site 485918002260 ATP binding site [chemical binding]; other site 485918002261 Walker B motif; other site 485918002262 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 485918002263 endonuclease III; Region: ENDO3c; smart00478 485918002264 minor groove reading motif; other site 485918002265 helix-hairpin-helix signature motif; other site 485918002266 substrate binding pocket [chemical binding]; other site 485918002267 active site 485918002268 M28 Zn-Peptidases; Region: M28_like_6; cd08656 485918002269 Peptidase family M28; Region: Peptidase_M28; pfam04389 485918002270 metal binding site [ion binding]; metal-binding site 485918002271 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 485918002272 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 485918002273 active site 485918002274 HIGH motif; other site 485918002275 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 485918002276 KMSKS motif; other site 485918002277 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 485918002278 tRNA binding surface [nucleotide binding]; other site 485918002279 anticodon binding site; other site 485918002280 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 485918002281 putative catalytic site [active] 485918002282 putative metal binding site [ion binding]; other site 485918002283 putative phosphate binding site [ion binding]; other site 485918002284 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 485918002285 putative catalytic site [active] 485918002286 putative metal binding site [ion binding]; other site 485918002287 putative phosphate binding site [ion binding]; other site 485918002288 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 485918002289 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 485918002290 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 485918002291 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 485918002292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918002293 S-adenosylmethionine binding site [chemical binding]; other site 485918002294 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918002295 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918002296 catalytic residues [active] 485918002297 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 485918002298 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 485918002299 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 485918002300 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 485918002301 FAD binding site [chemical binding]; other site 485918002302 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 485918002303 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 485918002304 Walker A/P-loop; other site 485918002305 ATP binding site [chemical binding]; other site 485918002306 Q-loop/lid; other site 485918002307 ABC transporter signature motif; other site 485918002308 Walker B; other site 485918002309 D-loop; other site 485918002310 H-loop/switch region; other site 485918002311 GH3 auxin-responsive promoter; Region: GH3; pfam03321 485918002312 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 485918002313 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 485918002314 NAD(P) binding site [chemical binding]; other site 485918002315 homotetramer interface [polypeptide binding]; other site 485918002316 homodimer interface [polypeptide binding]; other site 485918002317 active site 485918002318 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 485918002319 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 485918002320 PSP1 C-terminal conserved region; Region: PSP1; cl00770 485918002321 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 485918002322 DNA polymerase III subunit delta'; Validated; Region: PRK08485 485918002323 DNA polymerase III subunit delta'; Validated; Region: PRK08058 485918002324 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 485918002325 catalytic residues [active] 485918002326 dimer interface [polypeptide binding]; other site 485918002327 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 485918002328 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 485918002329 active site 485918002330 DNA repair protein RadA; Provisional; Region: PRK11823 485918002331 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 485918002332 Walker A motif/ATP binding site; other site 485918002333 ATP binding site [chemical binding]; other site 485918002334 Walker B motif; other site 485918002335 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 485918002336 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 485918002337 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 485918002338 23S rRNA interface [nucleotide binding]; other site 485918002339 L3 interface [polypeptide binding]; other site 485918002340 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 485918002341 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 485918002342 rRNA interaction site [nucleotide binding]; other site 485918002343 S8 interaction site; other site 485918002344 elongation factor Ts; Provisional; Region: tsf; PRK09377 485918002345 UBA/TS-N domain; Region: UBA; pfam00627 485918002346 Elongation factor TS; Region: EF_TS; pfam00889 485918002347 Elongation factor TS; Region: EF_TS; pfam00889 485918002348 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 485918002349 putative nucleotide binding site [chemical binding]; other site 485918002350 uridine monophosphate binding site [chemical binding]; other site 485918002351 homohexameric interface [polypeptide binding]; other site 485918002352 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 485918002353 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 485918002354 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 485918002355 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 485918002356 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 485918002357 IHF - DNA interface [nucleotide binding]; other site 485918002358 IHF dimer interface [polypeptide binding]; other site 485918002359 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 485918002360 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 485918002361 putative active site [active] 485918002362 putative catalytic site [active] 485918002363 putative DNA binding site [nucleotide binding]; other site 485918002364 putative phosphate binding site [ion binding]; other site 485918002365 metal binding site A [ion binding]; metal-binding site 485918002366 putative AP binding site [nucleotide binding]; other site 485918002367 putative metal binding site B [ion binding]; other site 485918002368 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 485918002369 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 485918002370 substrate binding pocket [chemical binding]; other site 485918002371 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 485918002372 B12 binding site [chemical binding]; other site 485918002373 cobalt ligand [ion binding]; other site 485918002374 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 485918002375 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 485918002376 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 485918002377 recombination protein RecR; Reviewed; Region: recR; PRK00076 485918002378 RecR protein; Region: RecR; pfam02132 485918002379 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 485918002380 putative active site [active] 485918002381 putative metal-binding site [ion binding]; other site 485918002382 tetramer interface [polypeptide binding]; other site 485918002383 Bacterial Ig-like domain; Region: Big_5; pfam13205 485918002384 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918002385 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 485918002386 Part of AAA domain; Region: AAA_19; pfam13245 485918002387 Family description; Region: UvrD_C_2; pfam13538 485918002388 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 485918002389 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 485918002390 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 485918002391 putative hydrophobic ligand binding site [chemical binding]; other site 485918002392 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 485918002393 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918002394 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 485918002395 Transcriptional regulator [Transcription]; Region: LysR; COG0583 485918002396 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 485918002397 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 485918002398 putative dimerization interface [polypeptide binding]; other site 485918002399 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048 485918002400 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 485918002401 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918002402 binding surface 485918002403 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 485918002404 TPR motif; other site 485918002405 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 485918002406 metal ion-dependent adhesion site (MIDAS); other site 485918002407 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 485918002408 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 485918002409 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 485918002410 substrate-cofactor binding pocket; other site 485918002411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918002412 catalytic residue [active] 485918002413 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 485918002414 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918002415 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918002416 DNA binding residues [nucleotide binding] 485918002417 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 485918002418 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 485918002419 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 485918002420 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 485918002421 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 485918002422 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 485918002423 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 485918002424 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918002425 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930 485918002426 SusD family; Region: SusD; pfam07980 485918002427 acetyl-CoA synthetase; Provisional; Region: PRK00174 485918002428 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 485918002429 active site 485918002430 CoA binding site [chemical binding]; other site 485918002431 acyl-activating enzyme (AAE) consensus motif; other site 485918002432 AMP binding site [chemical binding]; other site 485918002433 acetate binding site [chemical binding]; other site 485918002434 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 485918002435 non-specific DNA binding site [nucleotide binding]; other site 485918002436 salt bridge; other site 485918002437 sequence-specific DNA binding site [nucleotide binding]; other site 485918002438 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 485918002439 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 485918002440 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 485918002441 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 485918002442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918002443 Major Facilitator Superfamily; Region: MFS_1; pfam07690 485918002444 putative substrate translocation pore; other site 485918002445 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 485918002446 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 485918002447 ATP-grasp domain; Region: ATP-grasp_4; cl17255 485918002448 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 485918002449 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 485918002450 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 485918002451 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 485918002452 ATP-grasp domain; Region: ATP-grasp_4; cl17255 485918002453 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 485918002454 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 485918002455 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 485918002456 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 485918002457 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 485918002458 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 485918002459 protein binding site [polypeptide binding]; other site 485918002460 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 485918002461 Domain interface; other site 485918002462 Peptide binding site; other site 485918002463 Active site tetrad [active] 485918002464 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 485918002465 Competence protein; Region: Competence; pfam03772 485918002466 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 485918002467 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 485918002468 purine monophosphate binding site [chemical binding]; other site 485918002469 dimer interface [polypeptide binding]; other site 485918002470 putative catalytic residues [active] 485918002471 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 485918002472 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 485918002473 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 485918002474 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918002475 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918002476 DNA binding residues [nucleotide binding] 485918002477 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918002478 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 485918002479 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 485918002480 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 485918002481 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 485918002482 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 485918002483 gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512 485918002484 gliding motility-associated protein GldE; Region: GldE; TIGR03520 485918002485 Domain of unknown function DUF21; Region: DUF21; pfam01595 485918002486 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 485918002487 Transporter associated domain; Region: CorC_HlyC; smart01091 485918002488 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 485918002489 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 485918002490 dimer interface [polypeptide binding]; other site 485918002491 ssDNA binding site [nucleotide binding]; other site 485918002492 tetramer (dimer of dimers) interface [polypeptide binding]; other site 485918002493 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 485918002494 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 485918002495 minor groove reading motif; other site 485918002496 helix-hairpin-helix signature motif; other site 485918002497 substrate binding pocket [chemical binding]; other site 485918002498 active site 485918002499 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 485918002500 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 485918002501 DNA binding and oxoG recognition site [nucleotide binding] 485918002502 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 485918002503 IHF - DNA interface [nucleotide binding]; other site 485918002504 IHF dimer interface [polypeptide binding]; other site 485918002505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918002506 TPR motif; other site 485918002507 binding surface 485918002508 TPR repeat; Region: TPR_11; pfam13414 485918002509 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 485918002510 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 485918002511 homodimer interface [polypeptide binding]; other site 485918002512 oligonucleotide binding site [chemical binding]; other site 485918002513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 485918002514 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 485918002515 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 485918002516 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 485918002517 homotrimer interaction site [polypeptide binding]; other site 485918002518 putative active site [active] 485918002519 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 485918002520 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 485918002521 Glycoprotease family; Region: Peptidase_M22; pfam00814 485918002522 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 485918002523 dimerization interface [polypeptide binding]; other site 485918002524 putative DNA binding site [nucleotide binding]; other site 485918002525 putative Zn2+ binding site [ion binding]; other site 485918002526 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 485918002527 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 485918002528 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 485918002529 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 485918002530 active site residue [active] 485918002531 glucose-1-dehydrogenase; Provisional; Region: PRK08936 485918002532 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 485918002533 NAD binding site [chemical binding]; other site 485918002534 homodimer interface [polypeptide binding]; other site 485918002535 active site 485918002536 BON domain; Region: BON; cl02771 485918002537 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 485918002538 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 485918002539 putative acyl-acceptor binding pocket; other site 485918002540 L-aspartate oxidase; Provisional; Region: PRK09077 485918002541 L-aspartate oxidase; Provisional; Region: PRK06175 485918002542 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 485918002543 YhhN-like protein; Region: YhhN; pfam07947 485918002544 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918002545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918002546 ATP binding site [chemical binding]; other site 485918002547 Mg2+ binding site [ion binding]; other site 485918002548 G-X-G motif; other site 485918002549 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 485918002550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918002551 active site 485918002552 phosphorylation site [posttranslational modification] 485918002553 intermolecular recognition site; other site 485918002554 dimerization interface [polypeptide binding]; other site 485918002555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918002556 Walker A motif; other site 485918002557 ATP binding site [chemical binding]; other site 485918002558 Walker B motif; other site 485918002559 arginine finger; other site 485918002560 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 485918002561 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918002562 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918002563 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918002564 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 485918002565 FtsX-like permease family; Region: FtsX; pfam02687 485918002566 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918002567 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 485918002568 FtsX-like permease family; Region: FtsX; pfam02687 485918002569 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 485918002570 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 485918002571 Walker A/P-loop; other site 485918002572 ATP binding site [chemical binding]; other site 485918002573 Q-loop/lid; other site 485918002574 ABC transporter signature motif; other site 485918002575 Walker B; other site 485918002576 D-loop; other site 485918002577 H-loop/switch region; other site 485918002578 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918002579 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 485918002580 FtsX-like permease family; Region: FtsX; pfam02687 485918002581 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 485918002582 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918002583 FtsX-like permease family; Region: FtsX; pfam02687 485918002584 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918002585 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918002586 FtsX-like permease family; Region: FtsX; pfam02687 485918002587 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 485918002588 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918002589 FtsX-like permease family; Region: FtsX; pfam02687 485918002590 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918002591 FtsX-like permease family; Region: FtsX; pfam02687 485918002592 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918002593 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 485918002594 FtsX-like permease family; Region: FtsX; pfam02687 485918002595 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918002596 FtsX-like permease family; Region: FtsX; pfam02687 485918002597 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 485918002598 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 485918002599 Walker A/P-loop; other site 485918002600 ATP binding site [chemical binding]; other site 485918002601 Q-loop/lid; other site 485918002602 ABC transporter signature motif; other site 485918002603 Walker B; other site 485918002604 D-loop; other site 485918002605 H-loop/switch region; other site 485918002606 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 485918002607 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918002608 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 485918002609 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918002610 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 485918002611 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 485918002612 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 485918002613 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 485918002614 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 485918002615 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918002616 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918002617 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918002618 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918002619 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918002620 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918002621 Predicted membrane protein [Function unknown]; Region: COG4270 485918002622 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 485918002623 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 485918002624 ATP binding site [chemical binding]; other site 485918002625 putative Mg++ binding site [ion binding]; other site 485918002626 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 485918002627 nucleotide binding region [chemical binding]; other site 485918002628 ATP-binding site [chemical binding]; other site 485918002629 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 485918002630 RNA binding site [nucleotide binding]; other site 485918002631 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918002632 FecR protein; Region: FecR; pfam04773 485918002633 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918002634 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918002635 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918002636 DNA binding residues [nucleotide binding] 485918002637 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918002638 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918002639 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918002640 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918002641 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918002642 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918002643 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918002644 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 485918002645 Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425 485918002646 active site 485918002647 metal binding site [ion binding]; metal-binding site 485918002648 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 485918002649 active site 485918002650 metal binding site [ion binding]; metal-binding site 485918002651 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 485918002652 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 485918002653 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 485918002654 Catalytic domain of Protein Kinases; Region: PKc; cd00180 485918002655 active site 485918002656 ATP binding site [chemical binding]; other site 485918002657 substrate binding site [chemical binding]; other site 485918002658 activation loop (A-loop); other site 485918002659 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 485918002660 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cd04434 485918002661 active site 485918002662 zinc binding site [ion binding]; other site 485918002663 HTH domain; Region: HTH_11; cl17392 485918002664 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918002665 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918002666 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918002667 Response regulator receiver domain; Region: Response_reg; pfam00072 485918002668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918002669 active site 485918002670 phosphorylation site [posttranslational modification] 485918002671 intermolecular recognition site; other site 485918002672 dimerization interface [polypeptide binding]; other site 485918002673 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 485918002674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918002675 active site 485918002676 phosphorylation site [posttranslational modification] 485918002677 intermolecular recognition site; other site 485918002678 dimerization interface [polypeptide binding]; other site 485918002679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918002680 Walker A motif; other site 485918002681 ATP binding site [chemical binding]; other site 485918002682 Walker B motif; other site 485918002683 arginine finger; other site 485918002684 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 485918002685 Low affinity iron permease; Region: Iron_permease; pfam04120 485918002686 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 485918002687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918002688 active site 485918002689 phosphorylation site [posttranslational modification] 485918002690 intermolecular recognition site; other site 485918002691 dimerization interface [polypeptide binding]; other site 485918002692 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918002693 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 485918002694 putative active site [active] 485918002695 heme pocket [chemical binding]; other site 485918002696 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918002697 dimer interface [polypeptide binding]; other site 485918002698 phosphorylation site [posttranslational modification] 485918002699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918002700 ATP binding site [chemical binding]; other site 485918002701 Mg2+ binding site [ion binding]; other site 485918002702 G-X-G motif; other site 485918002703 Response regulator receiver domain; Region: Response_reg; pfam00072 485918002704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918002705 active site 485918002706 phosphorylation site [posttranslational modification] 485918002707 intermolecular recognition site; other site 485918002708 dimerization interface [polypeptide binding]; other site 485918002709 CHASE3 domain; Region: CHASE3; pfam05227 485918002710 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918002711 dimer interface [polypeptide binding]; other site 485918002712 phosphorylation site [posttranslational modification] 485918002713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918002714 ATP binding site [chemical binding]; other site 485918002715 Mg2+ binding site [ion binding]; other site 485918002716 G-X-G motif; other site 485918002717 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 485918002718 dimerization interface [polypeptide binding]; other site 485918002719 metal binding site [ion binding]; metal-binding site 485918002720 short chain dehydrogenase; Provisional; Region: PRK06701 485918002721 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 485918002722 NAD binding site [chemical binding]; other site 485918002723 metal binding site [ion binding]; metal-binding site 485918002724 active site 485918002725 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 485918002726 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 485918002727 active site 485918002728 DNA binding site [nucleotide binding] 485918002729 Int/Topo IB signature motif; other site 485918002730 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 485918002731 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 485918002732 putative DNA binding site [nucleotide binding]; other site 485918002733 putative homodimer interface [polypeptide binding]; other site 485918002734 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 485918002735 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 485918002736 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 485918002737 active site 485918002738 DNA binding site [nucleotide binding] 485918002739 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 485918002740 DNA binding site [nucleotide binding] 485918002741 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 485918002742 nucleotide binding site [chemical binding]; other site 485918002743 Chromate transporter; Region: Chromate_transp; pfam02417 485918002744 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 485918002745 Chromate transporter; Region: Chromate_transp; pfam02417 485918002746 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 485918002747 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 485918002748 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 485918002749 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 485918002750 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 485918002751 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 485918002752 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 485918002753 putative dimer interface [polypeptide binding]; other site 485918002754 putative anticodon binding site; other site 485918002755 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 485918002756 homodimer interface [polypeptide binding]; other site 485918002757 motif 1; other site 485918002758 motif 2; other site 485918002759 active site 485918002760 motif 3; other site 485918002761 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 485918002762 transcription termination factor Rho; Provisional; Region: rho; PRK09376 485918002763 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 485918002764 RNA binding site [nucleotide binding]; other site 485918002765 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 485918002766 multimer interface [polypeptide binding]; other site 485918002767 Walker A motif; other site 485918002768 ATP binding site [chemical binding]; other site 485918002769 Walker B motif; other site 485918002770 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918002771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918002772 active site 485918002773 phosphorylation site [posttranslational modification] 485918002774 intermolecular recognition site; other site 485918002775 dimerization interface [polypeptide binding]; other site 485918002776 LytTr DNA-binding domain; Region: LytTR; cl04498 485918002777 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 485918002778 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 485918002779 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918002780 Histidine kinase; Region: His_kinase; pfam06580 485918002781 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 485918002782 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 485918002783 aromatic arch; other site 485918002784 DCoH dimer interaction site [polypeptide binding]; other site 485918002785 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 485918002786 DCoH tetramer interaction site [polypeptide binding]; other site 485918002787 substrate binding site [chemical binding]; other site 485918002788 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 485918002789 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 485918002790 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 485918002791 AsnC family; Region: AsnC_trans_reg; pfam01037 485918002792 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 485918002793 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 485918002794 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 485918002795 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 485918002796 hinge; other site 485918002797 active site 485918002798 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 485918002799 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 485918002800 catalytic site [active] 485918002801 G-X2-G-X-G-K; other site 485918002802 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 485918002803 Domain of unknown function DUF21; Region: DUF21; pfam01595 485918002804 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 485918002805 Transporter associated domain; Region: CorC_HlyC; smart01091 485918002806 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 485918002807 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 485918002808 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 485918002809 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918002810 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918002811 DNA binding residues [nucleotide binding] 485918002812 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 485918002813 Part of AAA domain; Region: AAA_19; pfam13245 485918002814 Family description; Region: UvrD_C_2; pfam13538 485918002815 RecX family; Region: RecX; pfam02631 485918002816 C-N hydrolase family amidase; Provisional; Region: PRK10438 485918002817 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 485918002818 putative active site [active] 485918002819 catalytic triad [active] 485918002820 dimer interface [polypeptide binding]; other site 485918002821 multimer interface [polypeptide binding]; other site 485918002822 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 485918002823 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918002824 putative metal binding site [ion binding]; other site 485918002825 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 485918002826 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 485918002827 active site 485918002828 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 485918002829 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 485918002830 thiamine monophosphate kinase; Provisional; Region: PRK05731 485918002831 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 485918002832 ATP binding site [chemical binding]; other site 485918002833 dimerization interface [polypeptide binding]; other site 485918002834 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 485918002835 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 485918002836 active site 485918002837 dimerization interface [polypeptide binding]; other site 485918002838 GH3 auxin-responsive promoter; Region: GH3; pfam03321 485918002839 LysE type translocator; Region: LysE; cl00565 485918002840 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 485918002841 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 485918002842 TPP-binding site [chemical binding]; other site 485918002843 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 485918002844 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918002845 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918002846 binding surface 485918002847 TPR motif; other site 485918002848 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918002849 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918002850 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918002851 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 485918002852 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918002853 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918002854 Phytase; Region: Phytase; cl17685 485918002855 SdpI/YhfL protein family; Region: SdpI; pfam13630 485918002856 AMIN domain; Region: AMIN; pfam11741 485918002857 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 485918002858 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 485918002859 active site 485918002860 metal binding site [ion binding]; metal-binding site 485918002861 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 485918002862 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 485918002863 active site 485918002864 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918002865 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 485918002866 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_e; cd04192 485918002867 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 485918002868 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 485918002869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 485918002870 dimer interface [polypeptide binding]; other site 485918002871 conserved gate region; other site 485918002872 putative PBP binding loops; other site 485918002873 ABC-ATPase subunit interface; other site 485918002874 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 485918002875 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 485918002876 gliding motility-associated protein GldC; Region: GldC; TIGR03515 485918002877 Yqey-like protein; Region: YqeY; pfam09424 485918002878 Colicin V production protein; Region: Colicin_V; pfam02674 485918002879 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918002880 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 485918002881 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 485918002882 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01911 485918002883 ATP-NAD kinase; Region: NAD_kinase; pfam01513 485918002884 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 485918002885 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 485918002886 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 485918002887 catalytic residue [active] 485918002888 putative FPP diphosphate binding site; other site 485918002889 putative FPP binding hydrophobic cleft; other site 485918002890 dimer interface [polypeptide binding]; other site 485918002891 putative IPP diphosphate binding site; other site 485918002892 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 485918002893 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 485918002894 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 485918002895 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 485918002896 Surface antigen; Region: Bac_surface_Ag; pfam01103 485918002897 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 485918002898 periplasmic chaperone; Provisional; Region: PRK10780 485918002899 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 485918002900 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 485918002901 Haemolytic domain; Region: Haemolytic; pfam01809 485918002902 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 485918002903 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 485918002904 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 485918002905 protein binding site [polypeptide binding]; other site 485918002906 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 485918002907 Catalytic dyad [active] 485918002908 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 485918002909 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 485918002910 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 485918002911 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 485918002912 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 485918002913 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 485918002914 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918002915 PAS fold; Region: PAS_3; pfam08447 485918002916 putative active site [active] 485918002917 heme pocket [chemical binding]; other site 485918002918 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918002919 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918002920 DNA binding residues [nucleotide binding] 485918002921 dimerization interface [polypeptide binding]; other site 485918002922 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 485918002923 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 485918002924 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 485918002925 nucleoside/Zn binding site; other site 485918002926 dimer interface [polypeptide binding]; other site 485918002927 catalytic motif [active] 485918002928 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 485918002929 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 485918002930 nucleotide binding pocket [chemical binding]; other site 485918002931 K-X-D-G motif; other site 485918002932 catalytic site [active] 485918002933 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 485918002934 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 485918002935 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 485918002936 Dimer interface [polypeptide binding]; other site 485918002937 BRCT sequence motif; other site 485918002938 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 485918002939 B12 binding site [chemical binding]; other site 485918002940 cobalt ligand [ion binding]; other site 485918002941 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 485918002942 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 485918002943 Uncharacterized conserved protein [Function unknown]; Region: COG3538 485918002944 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 485918002945 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918002946 Walker A/P-loop; other site 485918002947 ATP binding site [chemical binding]; other site 485918002948 Q-loop/lid; other site 485918002949 ABC transporter signature motif; other site 485918002950 Walker B; other site 485918002951 D-loop; other site 485918002952 H-loop/switch region; other site 485918002953 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 485918002954 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 485918002955 FeS/SAM binding site; other site 485918002956 DinB superfamily; Region: DinB_2; pfam12867 485918002957 Part of AAA domain; Region: AAA_19; pfam13245 485918002958 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 485918002959 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 485918002960 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 485918002961 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918002962 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 485918002963 DNA binding residues [nucleotide binding] 485918002964 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 485918002965 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 485918002966 UDP-galactopyranose mutase; Region: GLF; pfam03275 485918002967 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 485918002968 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 485918002969 SLBB domain; Region: SLBB; pfam10531 485918002970 SLBB domain; Region: SLBB; pfam10531 485918002971 SLBB domain; Region: SLBB; pfam10531 485918002972 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 485918002973 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 485918002974 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 485918002975 putative NAD(P) binding site [chemical binding]; other site 485918002976 active site 485918002977 putative substrate binding site [chemical binding]; other site 485918002978 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 485918002979 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 485918002980 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 485918002981 ATP-grasp domain; Region: ATP-grasp_4; cl17255 485918002982 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 485918002983 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 485918002984 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 485918002985 active site 485918002986 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 485918002987 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 485918002988 active site 485918002989 homodimer interface [polypeptide binding]; other site 485918002990 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 485918002991 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 485918002992 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 485918002993 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 485918002994 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 485918002995 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 485918002996 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 485918002997 NADP-binding site; other site 485918002998 homotetramer interface [polypeptide binding]; other site 485918002999 substrate binding site [chemical binding]; other site 485918003000 homodimer interface [polypeptide binding]; other site 485918003001 active site 485918003002 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 485918003003 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 485918003004 NADP binding site [chemical binding]; other site 485918003005 active site 485918003006 putative substrate binding site [chemical binding]; other site 485918003007 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 485918003008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918003009 Walker A/P-loop; other site 485918003010 ATP binding site [chemical binding]; other site 485918003011 Q-loop/lid; other site 485918003012 ABC transporter signature motif; other site 485918003013 Walker B; other site 485918003014 D-loop; other site 485918003015 H-loop/switch region; other site 485918003016 ABC transporter; Region: ABC_tran_2; pfam12848 485918003017 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 485918003018 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 485918003019 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918003020 DNA binding residues [nucleotide binding] 485918003021 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918003022 FecR protein; Region: FecR; pfam04773 485918003023 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918003024 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918003025 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918003026 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918003027 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918003028 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918003029 SnoaL-like domain; Region: SnoaL_2; pfam12680 485918003030 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 485918003031 SurA N-terminal domain; Region: SurA_N; pfam09312 485918003032 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918003033 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918003034 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 485918003035 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 485918003036 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 485918003037 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 485918003038 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 485918003039 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 485918003040 active site 485918003041 catalytic triad [active] 485918003042 dimer interface [polypeptide binding]; other site 485918003043 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 485918003044 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918003045 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918003046 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918003047 NADP binding site [chemical binding]; other site 485918003048 active site 485918003049 steroid binding site; other site 485918003050 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 485918003051 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 485918003052 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 485918003053 acyl-activating enzyme (AAE) consensus motif; other site 485918003054 acyl-activating enzyme (AAE) consensus motif; other site 485918003055 putative AMP binding site [chemical binding]; other site 485918003056 putative active site [active] 485918003057 putative CoA binding site [chemical binding]; other site 485918003058 2TM domain; Region: 2TM; pfam13239 485918003059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918003060 Major Facilitator Superfamily; Region: MFS_1; pfam07690 485918003061 putative substrate translocation pore; other site 485918003062 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 485918003063 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 485918003064 DNA-binding site [nucleotide binding]; DNA binding site 485918003065 FCD domain; Region: FCD; pfam07729 485918003066 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918003067 binding surface 485918003068 TPR motif; other site 485918003069 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918003070 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 485918003071 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 485918003072 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 485918003073 Probable Catalytic site; other site 485918003074 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 485918003075 putative hydrophobic ligand binding site [chemical binding]; other site 485918003076 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 485918003077 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 485918003078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 485918003079 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 485918003080 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 485918003081 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 485918003082 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 485918003083 dimer interface [polypeptide binding]; other site 485918003084 active site 485918003085 metal binding site [ion binding]; metal-binding site 485918003086 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918003087 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918003088 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918003089 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 485918003090 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 485918003091 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918003092 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918003093 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918003094 Beta-lactamase; Region: Beta-lactamase; pfam00144 485918003095 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 485918003096 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 485918003097 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 485918003098 YceI-like domain; Region: YceI; pfam04264 485918003099 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 485918003100 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 485918003101 NAD(P) binding site [chemical binding]; other site 485918003102 catalytic residues [active] 485918003103 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 485918003104 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918003105 TPR motif; other site 485918003106 binding surface 485918003107 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918003108 TPR motif; other site 485918003109 TPR repeat; Region: TPR_11; pfam13414 485918003110 binding surface 485918003111 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 485918003112 Uncharacterized conserved protein [Function unknown]; Region: COG4198 485918003113 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 485918003114 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 485918003115 catalytic residue [active] 485918003116 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cd10981 485918003117 Zn binding site [ion binding]; other site 485918003118 Protein of unknown function (DUF502); Region: DUF502; cl01107 485918003119 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918003120 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918003121 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 485918003122 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918003123 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 485918003124 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918003125 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 485918003126 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 485918003127 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 485918003128 Protein export membrane protein; Region: SecD_SecF; cl14618 485918003129 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 485918003130 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 485918003131 kynureninase; Region: kynureninase; TIGR01814 485918003132 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 485918003133 catalytic residue [active] 485918003134 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 485918003135 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 485918003136 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918003137 FecR protein; Region: FecR; pfam04773 485918003138 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918003139 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918003140 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918003141 DNA binding residues [nucleotide binding] 485918003142 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 485918003143 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 485918003144 Bax inhibitor 1 like; Region: BaxI_1; cl17691 485918003145 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 485918003146 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 485918003147 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 485918003148 dimer interface [polypeptide binding]; other site 485918003149 PYR/PP interface [polypeptide binding]; other site 485918003150 TPP binding site [chemical binding]; other site 485918003151 substrate binding site [chemical binding]; other site 485918003152 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 485918003153 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 485918003154 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 485918003155 nucleoside transporter; Region: 2A0110; TIGR00889 485918003156 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 485918003157 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 485918003158 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 485918003159 minor groove reading motif; other site 485918003160 helix-hairpin-helix signature motif; other site 485918003161 substrate binding pocket [chemical binding]; other site 485918003162 active site 485918003163 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 485918003164 Septum formation initiator; Region: DivIC; cl17659 485918003165 enolase; Provisional; Region: eno; PRK00077 485918003166 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 485918003167 dimer interface [polypeptide binding]; other site 485918003168 metal binding site [ion binding]; metal-binding site 485918003169 substrate binding pocket [chemical binding]; other site 485918003170 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 485918003171 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 485918003172 Walker A/P-loop; other site 485918003173 ATP binding site [chemical binding]; other site 485918003174 Q-loop/lid; other site 485918003175 ABC transporter signature motif; other site 485918003176 Walker B; other site 485918003177 D-loop; other site 485918003178 H-loop/switch region; other site 485918003179 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 485918003180 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 485918003181 putative metal binding site [ion binding]; other site 485918003182 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 485918003183 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 485918003184 putative metal binding site [ion binding]; other site 485918003185 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 485918003186 metal ion-dependent adhesion site (MIDAS); other site 485918003187 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 485918003188 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 485918003189 motif II; other site 485918003190 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 485918003191 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 485918003192 putative metal binding site [ion binding]; other site 485918003193 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 485918003194 metal ion-dependent adhesion site (MIDAS); other site 485918003195 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 485918003196 metal ion-dependent adhesion site (MIDAS); other site 485918003197 Protein phosphatase 2C; Region: PP2C_2; pfam13672 485918003198 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 485918003199 substrate binding site [chemical binding]; other site 485918003200 activation loop (A-loop); other site 485918003201 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 485918003202 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 485918003203 putative active site [active] 485918003204 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918003205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918003206 active site 485918003207 phosphorylation site [posttranslational modification] 485918003208 intermolecular recognition site; other site 485918003209 dimerization interface [polypeptide binding]; other site 485918003210 LytTr DNA-binding domain; Region: LytTR; smart00850 485918003211 Histidine kinase; Region: His_kinase; pfam06580 485918003212 Peptidase family M23; Region: Peptidase_M23; pfam01551 485918003213 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 485918003214 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 485918003215 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 485918003216 catalytic triad [active] 485918003217 gliding motility-associated lipoprotein GldJ; Region: GldJ_short; TIGR03530 485918003218 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 485918003219 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 485918003220 active site 485918003221 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918003222 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 485918003223 homotrimer interaction site [polypeptide binding]; other site 485918003224 zinc binding site [ion binding]; other site 485918003225 CDP-binding sites; other site 485918003226 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 485918003227 trimer interface [polypeptide binding]; other site 485918003228 active site 485918003229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918003230 binding surface 485918003231 TPR motif; other site 485918003232 Tetratricopeptide repeat; Region: TPR_16; pfam13432 485918003233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918003234 binding surface 485918003235 TPR motif; other site 485918003236 TPR repeat; Region: TPR_11; pfam13414 485918003237 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918003238 binding surface 485918003239 TPR motif; other site 485918003240 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 485918003241 Peptidase family M23; Region: Peptidase_M23; pfam01551 485918003242 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 485918003243 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 485918003244 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 485918003245 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 485918003246 PA/protease or protease-like domain interface [polypeptide binding]; other site 485918003247 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 485918003248 Peptidase family M28; Region: Peptidase_M28; pfam04389 485918003249 metal binding site [ion binding]; metal-binding site 485918003250 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 485918003251 putative SAM binding site [chemical binding]; other site 485918003252 homodimer interface [polypeptide binding]; other site 485918003253 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 485918003254 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 485918003255 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 485918003256 active site 485918003257 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918003258 von Willebrand factor; Region: vWF_A; pfam12450 485918003259 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 485918003260 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 485918003261 metal ion-dependent adhesion site (MIDAS); other site 485918003262 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 485918003263 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 485918003264 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 485918003265 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 485918003266 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 485918003267 active site 485918003268 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 485918003269 WYL domain; Region: WYL; pfam13280 485918003270 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 485918003271 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 485918003272 dimer interface [polypeptide binding]; other site 485918003273 decamer (pentamer of dimers) interface [polypeptide binding]; other site 485918003274 catalytic triad [active] 485918003275 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 485918003276 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 485918003277 active site 485918003278 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 485918003279 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 485918003280 RNA binding surface [nucleotide binding]; other site 485918003281 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 485918003282 active site 485918003283 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 485918003284 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 485918003285 FeS/SAM binding site; other site 485918003286 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 485918003287 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 485918003288 dimer interface [polypeptide binding]; other site 485918003289 active site 485918003290 RNA polymerase sigma factor; Provisional; Region: PRK12513 485918003291 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918003292 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918003293 DNA binding residues [nucleotide binding] 485918003294 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 485918003295 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 485918003296 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918003297 ABC transporter signature motif; other site 485918003298 Walker B; other site 485918003299 D-loop; other site 485918003300 H-loop/switch region; other site 485918003301 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918003302 Walker A/P-loop; other site 485918003303 ATP binding site [chemical binding]; other site 485918003304 Q-loop/lid; other site 485918003305 ABC transporter signature motif; other site 485918003306 Walker B; other site 485918003307 D-loop; other site 485918003308 H-loop/switch region; other site 485918003309 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 485918003310 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 485918003311 Malic enzyme, N-terminal domain; Region: malic; pfam00390 485918003312 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 485918003313 putative NAD(P) binding site [chemical binding]; other site 485918003314 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 485918003315 Permease; Region: Permease; pfam02405 485918003316 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 485918003317 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 485918003318 Walker A/P-loop; other site 485918003319 ATP binding site [chemical binding]; other site 485918003320 Q-loop/lid; other site 485918003321 ABC transporter signature motif; other site 485918003322 Walker B; other site 485918003323 D-loop; other site 485918003324 H-loop/switch region; other site 485918003325 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 485918003326 CoA binding domain; Region: CoA_binding; smart00881 485918003327 CoA-ligase; Region: Ligase_CoA; pfam00549 485918003328 MG2 domain; Region: A2M_N; pfam01835 485918003329 Alpha-2-macroglobulin family; Region: A2M; pfam00207 485918003330 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 485918003331 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918003332 FtsX-like permease family; Region: FtsX; pfam02687 485918003333 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918003334 FtsX-like permease family; Region: FtsX; pfam02687 485918003335 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 485918003336 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 485918003337 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 485918003338 dimer interface [polypeptide binding]; other site 485918003339 anticodon binding site; other site 485918003340 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 485918003341 homodimer interface [polypeptide binding]; other site 485918003342 motif 1; other site 485918003343 active site 485918003344 motif 2; other site 485918003345 GAD domain; Region: GAD; pfam02938 485918003346 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 485918003347 active site 485918003348 motif 3; other site 485918003349 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 485918003350 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 485918003351 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 485918003352 active site 485918003353 catalytic triad [active] 485918003354 oxyanion hole [active] 485918003355 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 485918003356 active site 485918003357 oxyanion hole [active] 485918003358 catalytic triad [active] 485918003359 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 485918003360 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918003361 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918003362 dimer interface [polypeptide binding]; other site 485918003363 phosphorylation site [posttranslational modification] 485918003364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918003365 ATP binding site [chemical binding]; other site 485918003366 Mg2+ binding site [ion binding]; other site 485918003367 G-X-G motif; other site 485918003368 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 485918003369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918003370 active site 485918003371 phosphorylation site [posttranslational modification] 485918003372 intermolecular recognition site; other site 485918003373 dimerization interface [polypeptide binding]; other site 485918003374 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 485918003375 DNA binding site [nucleotide binding] 485918003376 Predicted membrane protein [Function unknown]; Region: COG4420 485918003377 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 485918003378 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 485918003379 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 485918003380 Walker A/P-loop; other site 485918003381 ATP binding site [chemical binding]; other site 485918003382 Q-loop/lid; other site 485918003383 ABC transporter signature motif; other site 485918003384 Walker B; other site 485918003385 D-loop; other site 485918003386 H-loop/switch region; other site 485918003387 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918003388 binding surface 485918003389 TPR motif; other site 485918003390 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 485918003391 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 485918003392 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 485918003393 ATP synthase A chain; Region: ATP-synt_A; cl00413 485918003394 ATP synthase subunit C; Region: ATP-synt_C; cl00466 485918003395 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 485918003396 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 485918003397 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 485918003398 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 485918003399 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 485918003400 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 485918003401 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 485918003402 beta subunit interaction interface [polypeptide binding]; other site 485918003403 Walker A motif; other site 485918003404 ATP binding site [chemical binding]; other site 485918003405 Walker B motif; other site 485918003406 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 485918003407 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918003408 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918003409 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 485918003410 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 485918003411 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 485918003412 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 485918003413 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 485918003414 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 485918003415 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 485918003416 NAD binding site [chemical binding]; other site 485918003417 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 485918003418 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 485918003419 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 485918003420 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 485918003421 nucleotide binding site/active site [active] 485918003422 HIT family signature motif; other site 485918003423 catalytic residue [active] 485918003424 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 485918003425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918003426 active site 485918003427 phosphorylation site [posttranslational modification] 485918003428 intermolecular recognition site; other site 485918003429 dimerization interface [polypeptide binding]; other site 485918003430 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 485918003431 DNA binding site [nucleotide binding] 485918003432 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 485918003433 active site 485918003434 putative DNA-binding cleft [nucleotide binding]; other site 485918003435 dimer interface [polypeptide binding]; other site 485918003436 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 485918003437 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 485918003438 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 485918003439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918003440 active site 485918003441 phosphorylation site [posttranslational modification] 485918003442 intermolecular recognition site; other site 485918003443 dimerization interface [polypeptide binding]; other site 485918003444 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 485918003445 DNA binding site [nucleotide binding] 485918003446 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 485918003447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918003448 active site 485918003449 phosphorylation site [posttranslational modification] 485918003450 intermolecular recognition site; other site 485918003451 dimerization interface [polypeptide binding]; other site 485918003452 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 485918003453 DNA binding site [nucleotide binding] 485918003454 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 485918003455 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 485918003456 dimerization interface [polypeptide binding]; other site 485918003457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918003458 dimer interface [polypeptide binding]; other site 485918003459 phosphorylation site [posttranslational modification] 485918003460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918003461 ATP binding site [chemical binding]; other site 485918003462 Mg2+ binding site [ion binding]; other site 485918003463 G-X-G motif; other site 485918003464 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 485918003465 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 485918003466 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918003467 Walker A motif; other site 485918003468 ATP binding site [chemical binding]; other site 485918003469 Walker B motif; other site 485918003470 arginine finger; other site 485918003471 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 485918003472 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 485918003473 M28 Zn-Peptidase IAP aminopeptidase may contain PA domain insert; Region: M28_like_5; cd08021 485918003474 Peptidase family M28; Region: Peptidase_M28; pfam04389 485918003475 metal binding site [ion binding]; metal-binding site 485918003476 Peptidase family M23; Region: Peptidase_M23; pfam01551 485918003477 aminoacyl-tRNA ligase; Region: PLN02563 485918003478 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 485918003479 active site 485918003480 HIGH motif; other site 485918003481 nucleotide binding site [chemical binding]; other site 485918003482 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 485918003483 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 485918003484 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 485918003485 active site 485918003486 KMSKS motif; other site 485918003487 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 485918003488 tRNA binding surface [nucleotide binding]; other site 485918003489 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 485918003490 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 485918003491 Bacitracin resistance protein BacA; Region: BacA; pfam02673 485918003492 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 485918003493 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 485918003494 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 485918003495 hexamer interface [polypeptide binding]; other site 485918003496 ligand binding site [chemical binding]; other site 485918003497 putative active site [active] 485918003498 NAD(P) binding site [chemical binding]; other site 485918003499 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 485918003500 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 485918003501 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 485918003502 metal-binding site [ion binding] 485918003503 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 485918003504 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 485918003505 motif II; other site 485918003506 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 485918003507 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 485918003508 ATP binding site [chemical binding]; other site 485918003509 putative Mg++ binding site [ion binding]; other site 485918003510 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 485918003511 nucleotide binding region [chemical binding]; other site 485918003512 ATP-binding site [chemical binding]; other site 485918003513 putative oxidoreductase; Provisional; Region: PRK11579 485918003514 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 485918003515 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 485918003516 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 485918003517 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 485918003518 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 485918003519 active site 485918003520 catalytic tetrad [active] 485918003521 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918003522 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918003523 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918003524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 485918003525 N2227-like protein; Region: N2227; pfam07942 485918003526 N2227-like protein; Region: N2227; pfam07942 485918003527 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 485918003528 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 485918003529 putative active site [active] 485918003530 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 485918003531 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918003532 Walker A/P-loop; other site 485918003533 ATP binding site [chemical binding]; other site 485918003534 Q-loop/lid; other site 485918003535 ABC transporter signature motif; other site 485918003536 Walker B; other site 485918003537 D-loop; other site 485918003538 H-loop/switch region; other site 485918003539 AAA-like domain; Region: AAA_10; pfam12846 485918003540 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 485918003541 oligomerisation interface [polypeptide binding]; other site 485918003542 mobile loop; other site 485918003543 roof hairpin; other site 485918003544 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 485918003545 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 485918003546 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918003547 Walker A/P-loop; other site 485918003548 ATP binding site [chemical binding]; other site 485918003549 ABC transporter; Region: ABC_tran; pfam00005 485918003550 Q-loop/lid; other site 485918003551 ABC transporter signature motif; other site 485918003552 Walker B; other site 485918003553 D-loop; other site 485918003554 H-loop/switch region; other site 485918003555 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 485918003556 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 485918003557 active site 485918003558 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 485918003559 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 485918003560 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 485918003561 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 485918003562 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 485918003563 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 485918003564 trimer interface [polypeptide binding]; other site 485918003565 active site 485918003566 UDP-GlcNAc binding site [chemical binding]; other site 485918003567 lipid binding site [chemical binding]; lipid-binding site 485918003568 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 485918003569 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 485918003570 Zn2+ binding site [ion binding]; other site 485918003571 Mg2+ binding site [ion binding]; other site 485918003572 Response regulator receiver domain; Region: Response_reg; pfam00072 485918003573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918003574 active site 485918003575 phosphorylation site [posttranslational modification] 485918003576 intermolecular recognition site; other site 485918003577 dimerization interface [polypeptide binding]; other site 485918003578 PglZ domain; Region: PglZ; pfam08665 485918003579 putative hydrolase; Provisional; Region: PRK02113 485918003580 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 485918003581 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 485918003582 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 485918003583 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 485918003584 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 485918003585 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 485918003586 FAD binding site [chemical binding]; other site 485918003587 homotetramer interface [polypeptide binding]; other site 485918003588 substrate binding pocket [chemical binding]; other site 485918003589 catalytic base [active] 485918003590 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 485918003591 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 485918003592 tetrameric interface [polypeptide binding]; other site 485918003593 activator binding site; other site 485918003594 NADP binding site [chemical binding]; other site 485918003595 substrate binding site [chemical binding]; other site 485918003596 catalytic residues [active] 485918003597 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 485918003598 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 485918003599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918003600 Walker A motif; other site 485918003601 ATP binding site [chemical binding]; other site 485918003602 Walker B motif; other site 485918003603 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 485918003604 Clp protease; Region: CLP_protease; pfam00574 485918003605 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 485918003606 oligomer interface [polypeptide binding]; other site 485918003607 active site residues [active] 485918003608 trigger factor; Region: tig; TIGR00115 485918003609 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 485918003610 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 485918003611 active site 485918003612 Mn binding site [ion binding]; other site 485918003613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918003614 putative substrate translocation pore; other site 485918003615 Major Facilitator Superfamily; Region: MFS_1; pfam07690 485918003616 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 485918003617 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 485918003618 metal binding site [ion binding]; metal-binding site 485918003619 dimer interface [polypeptide binding]; other site 485918003620 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918003621 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918003622 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918003623 Predicted membrane protein [Function unknown]; Region: COG3503 485918003624 SnoaL-like domain; Region: SnoaL_2; pfam12680 485918003625 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918003626 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918003627 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 485918003628 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 485918003629 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 485918003630 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 485918003631 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918003632 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918003633 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918003634 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 485918003635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918003636 putative substrate translocation pore; other site 485918003637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918003638 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 485918003639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918003640 putative substrate translocation pore; other site 485918003641 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918003642 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 485918003643 active site 485918003644 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918003645 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 485918003646 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 485918003647 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 485918003648 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 485918003649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918003650 active site 485918003651 phosphorylation site [posttranslational modification] 485918003652 intermolecular recognition site; other site 485918003653 dimerization interface [polypeptide binding]; other site 485918003654 Response regulator receiver domain; Region: Response_reg; pfam00072 485918003655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918003656 active site 485918003657 phosphorylation site [posttranslational modification] 485918003658 intermolecular recognition site; other site 485918003659 dimerization interface [polypeptide binding]; other site 485918003660 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918003661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918003662 dimer interface [polypeptide binding]; other site 485918003663 phosphorylation site [posttranslational modification] 485918003664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918003665 ATP binding site [chemical binding]; other site 485918003666 Mg2+ binding site [ion binding]; other site 485918003667 G-X-G motif; other site 485918003668 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 485918003669 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 485918003670 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918003671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918003672 ATP binding site [chemical binding]; other site 485918003673 Mg2+ binding site [ion binding]; other site 485918003674 G-X-G motif; other site 485918003675 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 485918003676 ATP binding site [chemical binding]; other site 485918003677 substrate interface [chemical binding]; other site 485918003678 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 485918003679 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 485918003680 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 485918003681 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 485918003682 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 485918003683 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 485918003684 active site 485918003685 Predicted permeases [General function prediction only]; Region: COG0795 485918003686 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 485918003687 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 485918003688 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 485918003689 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 485918003690 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 485918003691 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918003692 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 485918003693 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918003694 DNA binding residues [nucleotide binding] 485918003695 signal recognition particle protein; Provisional; Region: PRK10867 485918003696 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 485918003697 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 485918003698 P loop; other site 485918003699 GTP binding site [chemical binding]; other site 485918003700 Signal peptide binding domain; Region: SRP_SPB; pfam02978 485918003701 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 485918003702 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 485918003703 RimM N-terminal domain; Region: RimM; pfam01782 485918003704 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 485918003705 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 485918003706 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 485918003707 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 485918003708 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 485918003709 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 485918003710 N-acetyl-D-glucosamine binding site [chemical binding]; other site 485918003711 catalytic residue [active] 485918003712 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 485918003713 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 485918003714 Phosphoesterase family; Region: Phosphoesterase; pfam04185 485918003715 Phosphoesterase family; Region: Phosphoesterase; pfam04185 485918003716 Domain of unknown function (DUF756); Region: DUF756; pfam05506 485918003717 Domain of unknown function (DUF756); Region: DUF756; pfam05506 485918003718 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 485918003719 classical (c) SDRs; Region: SDR_c; cd05233 485918003720 NAD(P) binding site [chemical binding]; other site 485918003721 active site 485918003722 Fe-S metabolism associated domain; Region: SufE; cl00951 485918003723 KWG Leptospira; Region: KWG; pfam07656 485918003724 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 485918003725 DNA topoisomerase III; Provisional; Region: PRK07726 485918003726 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 485918003727 active site 485918003728 putative interdomain interaction site [polypeptide binding]; other site 485918003729 putative metal-binding site [ion binding]; other site 485918003730 putative nucleotide binding site [chemical binding]; other site 485918003731 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 485918003732 domain I; other site 485918003733 DNA binding groove [nucleotide binding] 485918003734 phosphate binding site [ion binding]; other site 485918003735 domain II; other site 485918003736 domain III; other site 485918003737 nucleotide binding site [chemical binding]; other site 485918003738 catalytic site [active] 485918003739 domain IV; other site 485918003740 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 485918003741 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 485918003742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918003743 active site 485918003744 phosphorylation site [posttranslational modification] 485918003745 intermolecular recognition site; other site 485918003746 dimerization interface [polypeptide binding]; other site 485918003747 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 485918003748 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 485918003749 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 485918003750 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 485918003751 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918003752 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918003753 ligand binding site [chemical binding]; other site 485918003754 flexible hinge region; other site 485918003755 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918003756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918003757 ATP binding site [chemical binding]; other site 485918003758 Mg2+ binding site [ion binding]; other site 485918003759 G-X-G motif; other site 485918003760 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 485918003761 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 485918003762 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918003763 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918003764 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918003765 GAF domain; Region: GAF_2; pfam13185 485918003766 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 485918003767 GAF domain; Region: GAF; cl17456 485918003768 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 485918003769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918003770 Walker A motif; other site 485918003771 ATP binding site [chemical binding]; other site 485918003772 Walker B motif; other site 485918003773 arginine finger; other site 485918003774 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 485918003775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918003776 active site 485918003777 phosphorylation site [posttranslational modification] 485918003778 intermolecular recognition site; other site 485918003779 dimerization interface [polypeptide binding]; other site 485918003780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918003781 Walker A motif; other site 485918003782 ATP binding site [chemical binding]; other site 485918003783 Walker B motif; other site 485918003784 arginine finger; other site 485918003785 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 485918003786 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918003787 OsmC-like protein; Region: OsmC; cl00767 485918003788 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918003789 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 485918003790 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 485918003791 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 485918003792 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918003793 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918003794 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918003795 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918003796 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 485918003797 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 485918003798 FecR protein; Region: FecR; pfam04773 485918003799 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 485918003800 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 485918003801 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 485918003802 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 485918003803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918003804 Walker A/P-loop; other site 485918003805 ATP binding site [chemical binding]; other site 485918003806 Q-loop/lid; other site 485918003807 ABC transporter signature motif; other site 485918003808 Walker B; other site 485918003809 D-loop; other site 485918003810 H-loop/switch region; other site 485918003811 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 485918003812 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918003813 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918003814 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918003815 DNA binding residues [nucleotide binding] 485918003816 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 485918003817 putative active site [active] 485918003818 putative catalytic site [active] 485918003819 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 485918003820 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 485918003821 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 485918003822 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 485918003823 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 485918003824 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 485918003825 type-a response regulator protein; Provisional; Region: PLN03029 485918003826 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 485918003827 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 485918003828 Cl- selectivity filter; other site 485918003829 Cl- binding residues [ion binding]; other site 485918003830 pore gating glutamate residue; other site 485918003831 dimer interface [polypeptide binding]; other site 485918003832 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 485918003833 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 485918003834 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 485918003835 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918003836 putative active site [active] 485918003837 heme pocket [chemical binding]; other site 485918003838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918003839 dimer interface [polypeptide binding]; other site 485918003840 phosphorylation site [posttranslational modification] 485918003841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918003842 ATP binding site [chemical binding]; other site 485918003843 Mg2+ binding site [ion binding]; other site 485918003844 G-X-G motif; other site 485918003845 Response regulator receiver domain; Region: Response_reg; pfam00072 485918003846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918003847 active site 485918003848 phosphorylation site [posttranslational modification] 485918003849 intermolecular recognition site; other site 485918003850 dimerization interface [polypeptide binding]; other site 485918003851 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 485918003852 active site 485918003853 catalytic residues [active] 485918003854 Predicted transcriptional regulator [Transcription]; Region: COG1959 485918003855 Transcriptional regulator; Region: Rrf2; pfam02082 485918003856 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 485918003857 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 485918003858 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918003859 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918003860 ligand binding site [chemical binding]; other site 485918003861 flexible hinge region; other site 485918003862 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 485918003863 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 485918003864 potential catalytic triad [active] 485918003865 conserved cys residue [active] 485918003866 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 485918003867 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 485918003868 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 485918003869 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 485918003870 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 485918003871 active site 485918003872 catalytic tetrad [active] 485918003873 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918003874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918003875 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918003876 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918003877 ligand binding site [chemical binding]; other site 485918003878 flexible hinge region; other site 485918003879 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 485918003880 Transposase; Region: HTH_Tnp_1; pfam01527 485918003881 HTH-like domain; Region: HTH_21; pfam13276 485918003882 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 485918003883 Integrase core domain; Region: rve; pfam00665 485918003884 Integrase core domain; Region: rve_3; pfam13683 485918003885 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 485918003886 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 485918003887 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 485918003888 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 485918003889 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 485918003890 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 485918003891 Phosphoglycerate kinase; Region: PGK; pfam00162 485918003892 substrate binding site [chemical binding]; other site 485918003893 hinge regions; other site 485918003894 ADP binding site [chemical binding]; other site 485918003895 catalytic site [active] 485918003896 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 485918003897 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 485918003898 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 485918003899 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 485918003900 Histidine kinase; Region: His_kinase; pfam06580 485918003901 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 485918003902 Repair protein; Region: Repair_PSII; pfam04536 485918003903 Repair protein; Region: Repair_PSII; pfam04536 485918003904 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 485918003905 Response regulator receiver domain; Region: Response_reg; pfam00072 485918003906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918003907 active site 485918003908 phosphorylation site [posttranslational modification] 485918003909 intermolecular recognition site; other site 485918003910 dimerization interface [polypeptide binding]; other site 485918003911 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918003912 FecR protein; Region: FecR; pfam04773 485918003913 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918003914 hypothetical protein; Provisional; Region: PRK08201 485918003915 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 485918003916 metal binding site [ion binding]; metal-binding site 485918003917 putative dimer interface [polypeptide binding]; other site 485918003918 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 485918003919 RNA binding surface [nucleotide binding]; other site 485918003920 diaminopimelate decarboxylase; Region: lysA; TIGR01048 485918003921 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 485918003922 active site 485918003923 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 485918003924 substrate binding site [chemical binding]; other site 485918003925 catalytic residues [active] 485918003926 dimer interface [polypeptide binding]; other site 485918003927 GAF domain; Region: GAF_2; pfam13185 485918003928 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 485918003929 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 485918003930 active site 485918003931 metal binding site [ion binding]; metal-binding site 485918003932 Surface antigen; Region: Bac_surface_Ag; pfam01103 485918003933 SdiA-regulated; Region: SdiA-regulated; pfam06977 485918003934 SdiA-regulated; Region: SdiA-regulated; cd09971 485918003935 putative active site [active] 485918003936 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 485918003937 Zn2+ binding site [ion binding]; other site 485918003938 Mg2+ binding site [ion binding]; other site 485918003939 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 485918003940 polyphosphate kinase; Provisional; Region: PRK05443 485918003941 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 485918003942 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 485918003943 domain interface [polypeptide binding]; other site 485918003944 active site 485918003945 catalytic site [active] 485918003946 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 485918003947 domain interface [polypeptide binding]; other site 485918003948 active site 485918003949 catalytic site [active] 485918003950 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 485918003951 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 485918003952 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 485918003953 Beta-Casp domain; Region: Beta-Casp; smart01027 485918003954 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 485918003955 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 485918003956 Peptidase family M1; Region: Peptidase_M1; pfam01433 485918003957 Zn binding site [ion binding]; other site 485918003958 HEAT repeats; Region: HEAT_2; pfam13646 485918003959 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 485918003960 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 485918003961 carboxyltransferase (CT) interaction site; other site 485918003962 biotinylation site [posttranslational modification]; other site 485918003963 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 485918003964 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 485918003965 dimerization interface 3.5A [polypeptide binding]; other site 485918003966 active site 485918003967 Transcriptional regulators [Transcription]; Region: PurR; COG1609 485918003968 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 485918003969 DNA binding site [nucleotide binding] 485918003970 domain linker motif; other site 485918003971 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 485918003972 dimerization interface [polypeptide binding]; other site 485918003973 ligand binding site [chemical binding]; other site 485918003974 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 485918003975 active site 485918003976 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 485918003977 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 485918003978 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 485918003979 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 485918003980 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 485918003981 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 485918003982 trmE is a tRNA modification GTPase; Region: trmE; cd04164 485918003983 G1 box; other site 485918003984 GTP/Mg2+ binding site [chemical binding]; other site 485918003985 Switch I region; other site 485918003986 G2 box; other site 485918003987 Switch II region; other site 485918003988 G3 box; other site 485918003989 G4 box; other site 485918003990 G5 box; other site 485918003991 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 485918003992 Major royal jelly protein; Region: MRJP; pfam03022 485918003993 Major royal jelly protein; Region: MRJP; pfam03022 485918003994 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 485918003995 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 485918003996 acyl-activating enzyme (AAE) consensus motif; other site 485918003997 AMP binding site [chemical binding]; other site 485918003998 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918003999 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 485918004000 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 485918004001 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 485918004002 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 485918004003 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 485918004004 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 485918004005 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 485918004006 active site 485918004007 zinc binding site [ion binding]; other site 485918004008 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918004009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918004010 active site 485918004011 phosphorylation site [posttranslational modification] 485918004012 intermolecular recognition site; other site 485918004013 dimerization interface [polypeptide binding]; other site 485918004014 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918004015 DNA binding residues [nucleotide binding] 485918004016 dimerization interface [polypeptide binding]; other site 485918004017 Condensation domain; Region: Condensation; pfam00668 485918004018 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 485918004019 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 485918004020 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 485918004021 active site 485918004022 TDP-binding site; other site 485918004023 acceptor substrate-binding pocket; other site 485918004024 homodimer interface [polypeptide binding]; other site 485918004025 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 485918004026 glycosyltransferase, MGT family; Region: MGT; TIGR01426 485918004027 active site 485918004028 TDP-binding site; other site 485918004029 acceptor substrate-binding pocket; other site 485918004030 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 485918004031 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918004032 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 485918004033 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 485918004034 active site 485918004035 Acyl transferase domain; Region: Acyl_transf_1; cl08282 485918004036 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 485918004037 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 485918004038 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 485918004039 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 485918004040 phosphate binding site [ion binding]; other site 485918004041 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 485918004042 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 485918004043 active site 485918004044 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 485918004045 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 485918004046 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 485918004047 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 485918004048 putative NADP binding site [chemical binding]; other site 485918004049 active site 485918004050 T5orf172 domain; Region: T5orf172; pfam10544 485918004051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 485918004052 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 485918004053 Protein of unknown function (DUF524); Region: DUF524; pfam04411 485918004054 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 485918004055 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 485918004056 active site 485918004057 catalytic tetrad [active] 485918004058 Domain present in PSD-95, Dlg, and ZO-1/2; Region: PDZ; smart00228 485918004059 protein binding site [polypeptide binding]; other site 485918004060 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 485918004061 Catalytic dyad [active] 485918004062 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 485918004063 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 485918004064 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 485918004065 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 485918004066 amidase catalytic site [active] 485918004067 Zn binding residues [ion binding]; other site 485918004068 substrate binding site [chemical binding]; other site 485918004069 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918004070 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918004071 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918004072 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 485918004073 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918004074 short chain dehydrogenase; Provisional; Region: PRK08339 485918004075 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918004076 NAD(P) binding site [chemical binding]; other site 485918004077 active site 485918004078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 485918004079 Transcriptional regulators [Transcription]; Region: PurR; COG1609 485918004080 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 485918004081 DNA binding site [nucleotide binding] 485918004082 domain linker motif; other site 485918004083 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 485918004084 dimerization interface [polypeptide binding]; other site 485918004085 ligand binding site [chemical binding]; other site 485918004086 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 485918004087 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 485918004088 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 485918004089 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 485918004090 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 485918004091 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 485918004092 dimer interface [polypeptide binding]; other site 485918004093 active site 485918004094 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918004095 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 485918004096 N-terminal plug; other site 485918004097 ligand-binding site [chemical binding]; other site 485918004098 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 485918004099 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 485918004100 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 485918004101 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 485918004102 alpha-gamma subunit interface [polypeptide binding]; other site 485918004103 beta-gamma subunit interface [polypeptide binding]; other site 485918004104 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 485918004105 gamma-beta subunit interface [polypeptide binding]; other site 485918004106 alpha-beta subunit interface [polypeptide binding]; other site 485918004107 urease subunit alpha; Reviewed; Region: ureC; PRK13207 485918004108 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 485918004109 subunit interactions [polypeptide binding]; other site 485918004110 active site 485918004111 flap region; other site 485918004112 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 485918004113 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 485918004114 dimer interface [polypeptide binding]; other site 485918004115 catalytic residues [active] 485918004116 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 485918004117 UreF; Region: UreF; pfam01730 485918004118 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 485918004119 UreD urease accessory protein; Region: UreD; pfam01774 485918004120 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 485918004121 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 485918004122 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 485918004123 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 485918004124 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 485918004125 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 485918004126 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 485918004127 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 485918004128 putative active site [active] 485918004129 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 485918004130 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 485918004131 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 485918004132 active site 485918004133 catalytic residues [active] 485918004134 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 485918004135 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 485918004136 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918004137 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 485918004138 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 485918004139 active site 485918004140 FMN binding site [chemical binding]; other site 485918004141 substrate binding site [chemical binding]; other site 485918004142 3Fe-4S cluster binding site [ion binding]; other site 485918004143 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 485918004144 Mechanosensitive ion channel; Region: MS_channel; pfam00924 485918004145 Putative carbohydrate binding domain; Region: CHB_HEX; cl03918 485918004146 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 485918004147 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 485918004148 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 485918004149 active site 485918004150 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 485918004151 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 485918004152 Ligand Binding Site [chemical binding]; other site 485918004153 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 485918004154 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 485918004155 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 485918004156 Predicted transcriptional regulator [Transcription]; Region: COG2378 485918004157 LytTr DNA-binding domain; Region: LytTR; cl04498 485918004158 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918004159 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918004160 DNA binding residues [nucleotide binding] 485918004161 dimerization interface [polypeptide binding]; other site 485918004162 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918004163 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918004164 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918004165 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918004166 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918004167 SusD family; Region: SusD; pfam07980 485918004168 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 485918004169 FAD binding pocket [chemical binding]; other site 485918004170 conserved FAD binding motif [chemical binding]; other site 485918004171 phosphate binding motif [ion binding]; other site 485918004172 beta-alpha-beta structure motif; other site 485918004173 NAD binding pocket [chemical binding]; other site 485918004174 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918004175 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918004176 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918004177 binding surface 485918004178 Tetratricopeptide repeat; Region: TPR_16; pfam13432 485918004179 TPR motif; other site 485918004180 Transcriptional regulators [Transcription]; Region: MarR; COG1846 485918004181 MarR family; Region: MarR_2; cl17246 485918004182 mannonate dehydratase; Provisional; Region: PRK03906 485918004183 mannonate dehydratase; Region: uxuA; TIGR00695 485918004184 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 485918004185 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 485918004186 MOFRL family; Region: MOFRL; pfam05161 485918004187 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 485918004188 Amidohydrolase; Region: Amidohydro_4; pfam13147 485918004189 active site 485918004190 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 485918004191 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 485918004192 active site 485918004193 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 485918004194 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 485918004195 active site 485918004196 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 485918004197 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 485918004198 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 485918004199 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 485918004200 active site 485918004201 HIGH motif; other site 485918004202 dimer interface [polypeptide binding]; other site 485918004203 KMSKS motif; other site 485918004204 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 485918004205 RNA binding surface [nucleotide binding]; other site 485918004206 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 485918004207 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 485918004208 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 485918004209 NADP binding site [chemical binding]; other site 485918004210 active site 485918004211 putative substrate binding site [chemical binding]; other site 485918004212 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 485918004213 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 485918004214 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 485918004215 NAD binding site [chemical binding]; other site 485918004216 substrate binding site [chemical binding]; other site 485918004217 homodimer interface [polypeptide binding]; other site 485918004218 active site 485918004219 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 485918004220 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 485918004221 NAD binding site [chemical binding]; other site 485918004222 putative substrate binding site 2 [chemical binding]; other site 485918004223 putative substrate binding site 1 [chemical binding]; other site 485918004224 active site 485918004225 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 485918004226 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 485918004227 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 485918004228 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 485918004229 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 485918004230 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 485918004231 inhibitor-cofactor binding pocket; inhibition site 485918004232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918004233 catalytic residue [active] 485918004234 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 485918004235 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 485918004236 thymidine kinase; Provisional; Region: PRK04296 485918004237 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918004238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918004239 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 485918004240 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 485918004241 FMN binding site [chemical binding]; other site 485918004242 active site 485918004243 substrate binding site [chemical binding]; other site 485918004244 catalytic residue [active] 485918004245 GtrA-like protein; Region: GtrA; pfam04138 485918004246 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 485918004247 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 485918004248 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 485918004249 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 485918004250 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 485918004251 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 485918004252 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 485918004253 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 485918004254 NAD(P) binding site [chemical binding]; other site 485918004255 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 485918004256 AMP nucleosidase; Provisional; Region: PRK07115 485918004257 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 485918004258 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 485918004259 Walker A/P-loop; other site 485918004260 ATP binding site [chemical binding]; other site 485918004261 Q-loop/lid; other site 485918004262 ABC transporter signature motif; other site 485918004263 Walker B; other site 485918004264 D-loop; other site 485918004265 H-loop/switch region; other site 485918004266 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 485918004267 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 485918004268 Walker A/P-loop; other site 485918004269 ATP binding site [chemical binding]; other site 485918004270 Q-loop/lid; other site 485918004271 ABC transporter signature motif; other site 485918004272 Walker B; other site 485918004273 D-loop; other site 485918004274 H-loop/switch region; other site 485918004275 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 485918004276 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 485918004277 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 485918004278 substrate binding site; other site 485918004279 dimer interface; other site 485918004280 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 485918004281 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 485918004282 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 485918004283 hypothetical protein; Reviewed; Region: PRK00024 485918004284 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 485918004285 MPN+ (JAMM) motif; other site 485918004286 Zinc-binding site [ion binding]; other site 485918004287 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 485918004288 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 485918004289 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 485918004290 active site 485918004291 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 485918004292 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 485918004293 5S rRNA interface [nucleotide binding]; other site 485918004294 CTC domain interface [polypeptide binding]; other site 485918004295 L16 interface [polypeptide binding]; other site 485918004296 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 485918004297 putative active site [active] 485918004298 catalytic residue [active] 485918004299 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 485918004300 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 485918004301 Transcriptional regulators [Transcription]; Region: MarR; COG1846 485918004302 MarR family; Region: MarR_2; pfam12802 485918004303 MarR family; Region: MarR_2; cl17246 485918004304 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 485918004305 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 485918004306 TPP-binding site [chemical binding]; other site 485918004307 tetramer interface [polypeptide binding]; other site 485918004308 heterodimer interface [polypeptide binding]; other site 485918004309 phosphorylation loop region [posttranslational modification] 485918004310 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 485918004311 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 485918004312 PYR/PP interface [polypeptide binding]; other site 485918004313 dimer interface [polypeptide binding]; other site 485918004314 TPP binding site [chemical binding]; other site 485918004315 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 485918004316 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 485918004317 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918004318 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 485918004319 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 485918004320 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 485918004321 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 485918004322 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918004323 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918004324 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918004325 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918004326 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918004327 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 485918004328 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918004329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918004330 active site 485918004331 phosphorylation site [posttranslational modification] 485918004332 intermolecular recognition site; other site 485918004333 dimerization interface [polypeptide binding]; other site 485918004334 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918004335 DNA binding residues [nucleotide binding] 485918004336 dimerization interface [polypeptide binding]; other site 485918004337 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 485918004338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918004339 ATP binding site [chemical binding]; other site 485918004340 Mg2+ binding site [ion binding]; other site 485918004341 G-X-G motif; other site 485918004342 Caspase domain; Region: Peptidase_C14; pfam00656 485918004343 TIR domain; Region: TIR_2; pfam13676 485918004344 Uncharacterized conserved protein [Function unknown]; Region: COG1262 485918004345 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 485918004346 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 485918004347 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 485918004348 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 485918004349 CCC1; Region: CCC1; cd02435 485918004350 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 485918004351 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 485918004352 spermidine synthase; Provisional; Region: PRK03612 485918004353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918004354 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 485918004355 Predicted membrane protein [Function unknown]; Region: COG4682 485918004356 yiaA/B two helix domain; Region: YiaAB; pfam05360 485918004357 yiaA/B two helix domain; Region: YiaAB; pfam05360 485918004358 Tic20-like protein; Region: Tic20; pfam09685 485918004359 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 485918004360 catalytic nucleophile [active] 485918004361 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 485918004362 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 485918004363 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 485918004364 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 485918004365 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 485918004366 Domain of unknown function (DUF1793); Region: DUF1793; pfam08760 485918004367 Domain of unknown function (DUF303); Region: DUF303; pfam03629 485918004368 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 485918004369 EamA-like transporter family; Region: EamA; pfam00892 485918004370 EamA-like transporter family; Region: EamA; pfam00892 485918004371 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 485918004372 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918004373 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918004374 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918004375 DNA binding residues [nucleotide binding] 485918004376 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918004377 FecR protein; Region: FecR; pfam04773 485918004378 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918004379 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918004380 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918004381 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918004382 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918004383 SusD family; Region: SusD; pfam07980 485918004384 SusE outer membrane protein; Region: SusE; pfam14292 485918004385 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 485918004386 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 485918004387 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 485918004388 GIY-YIG motif/motif A; other site 485918004389 putative active site [active] 485918004390 putative metal binding site [ion binding]; other site 485918004391 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 485918004392 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 485918004393 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 485918004394 ApbE family; Region: ApbE; pfam02424 485918004395 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 485918004396 Mechanosensitive ion channel; Region: MS_channel; pfam00924 485918004397 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 485918004398 putative FMN binding site [chemical binding]; other site 485918004399 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 485918004400 active site 485918004401 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 485918004402 active site 485918004403 dimerization interface [polypeptide binding]; other site 485918004404 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 485918004405 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 485918004406 homodimer interface [polypeptide binding]; other site 485918004407 substrate-cofactor binding pocket; other site 485918004408 catalytic residue [active] 485918004409 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 485918004410 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 485918004411 S17 interaction site [polypeptide binding]; other site 485918004412 S8 interaction site; other site 485918004413 16S rRNA interaction site [nucleotide binding]; other site 485918004414 streptomycin interaction site [chemical binding]; other site 485918004415 23S rRNA interaction site [nucleotide binding]; other site 485918004416 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 485918004417 30S ribosomal protein S7; Validated; Region: PRK05302 485918004418 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918004419 elongation factor G; Reviewed; Region: PRK12739 485918004420 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 485918004421 G1 box; other site 485918004422 putative GEF interaction site [polypeptide binding]; other site 485918004423 GTP/Mg2+ binding site [chemical binding]; other site 485918004424 Switch I region; other site 485918004425 G2 box; other site 485918004426 G3 box; other site 485918004427 Switch II region; other site 485918004428 G4 box; other site 485918004429 G5 box; other site 485918004430 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 485918004431 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 485918004432 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 485918004433 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 485918004434 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 485918004435 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 485918004436 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 485918004437 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 485918004438 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 485918004439 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 485918004440 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 485918004441 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 485918004442 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 485918004443 putative translocon binding site; other site 485918004444 protein-rRNA interface [nucleotide binding]; other site 485918004445 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 485918004446 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 485918004447 G-X-X-G motif; other site 485918004448 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 485918004449 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 485918004450 23S rRNA interface [nucleotide binding]; other site 485918004451 5S rRNA interface [nucleotide binding]; other site 485918004452 putative antibiotic binding site [chemical binding]; other site 485918004453 L25 interface [polypeptide binding]; other site 485918004454 L27 interface [polypeptide binding]; other site 485918004455 50S ribosomal protein L29; Reviewed; Region: PRK00306 485918004456 trigger factor interaction site; other site 485918004457 23S rRNA interface [nucleotide binding]; other site 485918004458 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 485918004459 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 485918004460 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 485918004461 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 485918004462 RNA binding site [nucleotide binding]; other site 485918004463 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 485918004464 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 485918004465 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 485918004466 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 485918004467 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 485918004468 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 485918004469 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 485918004470 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 485918004471 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 485918004472 5S rRNA interface [nucleotide binding]; other site 485918004473 23S rRNA interface [nucleotide binding]; other site 485918004474 L5 interface [polypeptide binding]; other site 485918004475 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 485918004476 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 485918004477 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 485918004478 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 485918004479 23S rRNA binding site [nucleotide binding]; other site 485918004480 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 485918004481 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 485918004482 SecY translocase; Region: SecY; pfam00344 485918004483 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 485918004484 active site 485918004485 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 485918004486 rRNA binding site [nucleotide binding]; other site 485918004487 predicted 30S ribosome binding site; other site 485918004488 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 485918004489 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 485918004490 30S ribosomal protein S13; Region: bact_S13; TIGR03631 485918004491 30S ribosomal protein S11; Validated; Region: PRK05309 485918004492 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 485918004493 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 485918004494 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 485918004495 RNA binding surface [nucleotide binding]; other site 485918004496 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 485918004497 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 485918004498 alphaNTD - beta interaction site [polypeptide binding]; other site 485918004499 alphaNTD homodimer interface [polypeptide binding]; other site 485918004500 alphaNTD - beta' interaction site [polypeptide binding]; other site 485918004501 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 485918004502 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 485918004503 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 485918004504 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 485918004505 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 485918004506 catalytic site [active] 485918004507 subunit interface [polypeptide binding]; other site 485918004508 aspartate aminotransferase; Provisional; Region: PRK07568 485918004509 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 485918004510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918004511 homodimer interface [polypeptide binding]; other site 485918004512 catalytic residue [active] 485918004513 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 485918004514 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 485918004515 tetramer interface [polypeptide binding]; other site 485918004516 TPP-binding site [chemical binding]; other site 485918004517 heterodimer interface [polypeptide binding]; other site 485918004518 phosphorylation loop region [posttranslational modification] 485918004519 3-methyl-2-oxobutanate dehydrogenase; Provisional; Region: PTZ00182 485918004520 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 485918004521 PYR/PP interface [polypeptide binding]; other site 485918004522 dimer interface [polypeptide binding]; other site 485918004523 TPP binding site [chemical binding]; other site 485918004524 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 485918004525 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 485918004526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918004527 active site 485918004528 phosphorylation site [posttranslational modification] 485918004529 intermolecular recognition site; other site 485918004530 dimerization interface [polypeptide binding]; other site 485918004531 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 485918004532 DNA binding site [nucleotide binding] 485918004533 hypothetical protein; Provisional; Region: PRK12378 485918004534 amino acid transporter; Region: 2A0306; TIGR00909 485918004535 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 485918004536 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 485918004537 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 485918004538 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 485918004539 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 485918004540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918004541 putative substrate translocation pore; other site 485918004542 Major Facilitator Superfamily; Region: MFS_1; pfam07690 485918004543 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 485918004544 MarR family; Region: MarR_2; cl17246 485918004545 malate dehydrogenase; Reviewed; Region: PRK06223 485918004546 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 485918004547 NAD(P) binding site [chemical binding]; other site 485918004548 dimer interface [polypeptide binding]; other site 485918004549 tetramer (dimer of dimers) interface [polypeptide binding]; other site 485918004550 substrate binding site [chemical binding]; other site 485918004551 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 485918004552 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918004553 elongation factor P; Validated; Region: PRK00529 485918004554 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 485918004555 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 485918004556 RNA binding site [nucleotide binding]; other site 485918004557 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 485918004558 RNA binding site [nucleotide binding]; other site 485918004559 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 485918004560 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 485918004561 carboxyltransferase (CT) interaction site; other site 485918004562 biotinylation site [posttranslational modification]; other site 485918004563 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 485918004564 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 485918004565 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 485918004566 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 485918004567 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 485918004568 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 485918004569 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 485918004570 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 485918004571 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 485918004572 dimerization interface [polypeptide binding]; other site 485918004573 ATP binding site [chemical binding]; other site 485918004574 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 485918004575 dimerization interface [polypeptide binding]; other site 485918004576 ATP binding site [chemical binding]; other site 485918004577 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 485918004578 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 485918004579 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 485918004580 catalytic residue [active] 485918004581 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 485918004582 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 485918004583 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 485918004584 enoyl-CoA hydratase; Provisional; Region: PRK05995 485918004585 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 485918004586 substrate binding site [chemical binding]; other site 485918004587 oxyanion hole (OAH) forming residues; other site 485918004588 trimer interface [polypeptide binding]; other site 485918004589 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 485918004590 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918004591 binding surface 485918004592 TPR motif; other site 485918004593 Tetratricopeptide repeat; Region: TPR_16; pfam13432 485918004594 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918004595 binding surface 485918004596 TPR motif; other site 485918004597 TPR repeat; Region: TPR_11; pfam13414 485918004598 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918004599 binding surface 485918004600 TPR motif; other site 485918004601 TPR repeat; Region: TPR_11; pfam13414 485918004602 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918004603 binding surface 485918004604 TPR motif; other site 485918004605 TPR repeat; Region: TPR_11; pfam13414 485918004606 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 485918004607 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 485918004608 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 485918004609 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 485918004610 shikimate binding site; other site 485918004611 NAD(P) binding site [chemical binding]; other site 485918004612 Methyltransferase domain; Region: Methyltransf_31; pfam13847 485918004613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918004614 S-adenosylmethionine binding site [chemical binding]; other site 485918004615 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 485918004616 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 485918004617 RNA binding site [nucleotide binding]; other site 485918004618 active site 485918004619 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 485918004620 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 485918004621 Surface antigen; Region: Bac_surface_Ag; pfam01103 485918004622 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 485918004623 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 485918004624 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 485918004625 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 485918004626 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918004627 FtsX-like permease family; Region: FtsX; pfam02687 485918004628 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 485918004629 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 485918004630 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 485918004631 active site 485918004632 intersubunit interactions; other site 485918004633 catalytic residue [active] 485918004634 RDD family; Region: RDD; pfam06271 485918004635 RDD family; Region: RDD; pfam06271 485918004636 Integral membrane protein DUF95; Region: DUF95; pfam01944 485918004637 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 485918004638 MoxR-like ATPases [General function prediction only]; Region: COG0714 485918004639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918004640 Walker A motif; other site 485918004641 ATP binding site [chemical binding]; other site 485918004642 Walker B motif; other site 485918004643 arginine finger; other site 485918004644 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 485918004645 Protein of unknown function DUF58; Region: DUF58; pfam01882 485918004646 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918004647 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918004648 DoxX-like family; Region: DoxX_2; pfam13564 485918004649 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 485918004650 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 485918004651 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918004652 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918004653 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918004654 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 485918004655 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 485918004656 FMN binding site [chemical binding]; other site 485918004657 substrate binding site [chemical binding]; other site 485918004658 putative catalytic residue [active] 485918004659 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 485918004660 Lumazine binding domain; Region: Lum_binding; pfam00677 485918004661 Lumazine binding domain; Region: Lum_binding; pfam00677 485918004662 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 485918004663 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 485918004664 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 485918004665 active site 485918004666 DNA binding site [nucleotide binding] 485918004667 Int/Topo IB signature motif; other site 485918004668 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 485918004669 30S subunit binding site; other site 485918004670 elongation factor Tu; Reviewed; Region: PRK00049 485918004671 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 485918004672 G1 box; other site 485918004673 GEF interaction site [polypeptide binding]; other site 485918004674 GTP/Mg2+ binding site [chemical binding]; other site 485918004675 Switch I region; other site 485918004676 G2 box; other site 485918004677 G3 box; other site 485918004678 Switch II region; other site 485918004679 G4 box; other site 485918004680 G5 box; other site 485918004681 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 485918004682 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 485918004683 Antibiotic Binding Site [chemical binding]; other site 485918004684 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 485918004685 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 485918004686 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 485918004687 putative homodimer interface [polypeptide binding]; other site 485918004688 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 485918004689 heterodimer interface [polypeptide binding]; other site 485918004690 homodimer interface [polypeptide binding]; other site 485918004691 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 485918004692 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 485918004693 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 485918004694 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 485918004695 23S rRNA interface [nucleotide binding]; other site 485918004696 L7/L12 interface [polypeptide binding]; other site 485918004697 putative thiostrepton binding site; other site 485918004698 L25 interface [polypeptide binding]; other site 485918004699 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 485918004700 mRNA/rRNA interface [nucleotide binding]; other site 485918004701 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 485918004702 23S rRNA interface [nucleotide binding]; other site 485918004703 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 485918004704 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 485918004705 core dimer interface [polypeptide binding]; other site 485918004706 peripheral dimer interface [polypeptide binding]; other site 485918004707 L10 interface [polypeptide binding]; other site 485918004708 L11 interface [polypeptide binding]; other site 485918004709 putative EF-Tu interaction site [polypeptide binding]; other site 485918004710 putative EF-G interaction site [polypeptide binding]; other site 485918004711 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 485918004712 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 485918004713 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 485918004714 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 485918004715 RPB11 interaction site [polypeptide binding]; other site 485918004716 RPB12 interaction site [polypeptide binding]; other site 485918004717 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 485918004718 RPB3 interaction site [polypeptide binding]; other site 485918004719 RPB1 interaction site [polypeptide binding]; other site 485918004720 RPB11 interaction site [polypeptide binding]; other site 485918004721 RPB10 interaction site [polypeptide binding]; other site 485918004722 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 485918004723 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 485918004724 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 485918004725 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 485918004726 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 485918004727 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 485918004728 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 485918004729 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 485918004730 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 485918004731 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 485918004732 DNA binding site [nucleotide binding] 485918004733 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 485918004734 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 485918004735 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 485918004736 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 485918004737 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918004738 FecR protein; Region: FecR; pfam04773 485918004739 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918004740 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 485918004741 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918004742 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918004743 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 485918004744 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 485918004745 protein binding site [polypeptide binding]; other site 485918004746 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 485918004747 Catalytic dyad [active] 485918004748 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918004749 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918004750 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918004751 DNA binding residues [nucleotide binding] 485918004752 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 485918004753 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 485918004754 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 485918004755 putative active site [active] 485918004756 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 485918004757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918004758 S-adenosylmethionine binding site [chemical binding]; other site 485918004759 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 485918004760 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 485918004761 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918004762 NAD(P) binding site [chemical binding]; other site 485918004763 active site 485918004764 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 485918004765 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 485918004766 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 485918004767 motif II; other site 485918004768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 485918004769 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 485918004770 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 485918004771 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 485918004772 Catalytic site [active] 485918004773 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918004774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918004775 active site 485918004776 phosphorylation site [posttranslational modification] 485918004777 intermolecular recognition site; other site 485918004778 dimerization interface [polypeptide binding]; other site 485918004779 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918004780 DNA binding residues [nucleotide binding] 485918004781 dimerization interface [polypeptide binding]; other site 485918004782 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 485918004783 Histidine kinase; Region: HisKA_3; pfam07730 485918004784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918004785 ATP binding site [chemical binding]; other site 485918004786 Mg2+ binding site [ion binding]; other site 485918004787 G-X-G motif; other site 485918004788 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918004789 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918004790 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918004791 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918004792 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918004793 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918004794 Domain of unknown function (DUF4302); Region: DUF4302; pfam14135 485918004795 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 485918004796 Right handed beta helix region; Region: Beta_helix; pfam13229 485918004797 Right handed beta helix region; Region: Beta_helix; pfam13229 485918004798 Right handed beta helix region; Region: Beta_helix; pfam13229 485918004799 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918004800 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918004801 FOG: PKD repeat [General function prediction only]; Region: COG3291 485918004802 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918004803 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918004804 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918004805 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 485918004806 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 485918004807 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 485918004808 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 485918004809 ligand binding site [chemical binding]; other site 485918004810 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 485918004811 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 485918004812 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 485918004813 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 485918004814 dimerization interface [polypeptide binding]; other site 485918004815 putative DNA binding site [nucleotide binding]; other site 485918004816 putative Zn2+ binding site [ion binding]; other site 485918004817 diaminopimelate decarboxylase; Region: lysA; TIGR01048 485918004818 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 485918004819 active site 485918004820 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 485918004821 substrate binding site [chemical binding]; other site 485918004822 catalytic residues [active] 485918004823 dimer interface [polypeptide binding]; other site 485918004824 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 485918004825 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 485918004826 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 485918004827 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 485918004828 Glycosyl hydrolase family 43; Region: GH43_3; cd08982 485918004829 active site 485918004830 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 485918004831 sugar binding site [chemical binding]; other site 485918004832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4295 485918004833 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 485918004834 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 485918004835 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 485918004836 active site 485918004837 metal binding site [ion binding]; metal-binding site 485918004838 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 485918004839 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 485918004840 dimer interface [polypeptide binding]; other site 485918004841 PYR/PP interface [polypeptide binding]; other site 485918004842 TPP binding site [chemical binding]; other site 485918004843 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 485918004844 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 485918004845 TPP-binding site [chemical binding]; other site 485918004846 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918004847 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 485918004848 ligand binding site [chemical binding]; other site 485918004849 flexible hinge region; other site 485918004850 short chain dehydrogenase; Provisional; Region: PRK06500 485918004851 classical (c) SDRs; Region: SDR_c; cd05233 485918004852 NAD(P) binding site [chemical binding]; other site 485918004853 active site 485918004854 DinB superfamily; Region: DinB_2; pfam12867 485918004855 Methyltransferase domain; Region: Methyltransf_23; pfam13489 485918004856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918004857 S-adenosylmethionine binding site [chemical binding]; other site 485918004858 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918004859 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918004860 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918004861 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 485918004862 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918004863 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918004864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918004865 NmrA-like family; Region: NmrA; pfam05368 485918004866 NAD(P) binding site [chemical binding]; other site 485918004867 active site 485918004868 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918004869 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 485918004870 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 485918004871 Peptidase S8 family domain in Subtilisin_Novo-like proteins; Region: Peptidases_S8_Subtilisin_Novo-like; cd07483 485918004872 active site 485918004873 catalytic triad [active] 485918004874 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918004875 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918004876 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 485918004877 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 485918004878 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 485918004879 E3 interaction surface; other site 485918004880 lipoyl attachment site [posttranslational modification]; other site 485918004881 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918004882 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 485918004883 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918004884 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918004885 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918004886 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918004887 Fasciclin domain; Region: Fasciclin; cl02663 485918004888 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 485918004889 putative metal binding site [ion binding]; other site 485918004890 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 485918004891 putative metal binding site [ion binding]; other site 485918004892 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918004893 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918004894 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918004895 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 485918004896 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918004897 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 485918004898 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 485918004899 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 485918004900 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 485918004901 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 485918004902 putative ADP-ribose binding site [chemical binding]; other site 485918004903 putative active site [active] 485918004904 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 485918004905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918004906 Response regulator receiver domain; Region: Response_reg; pfam00072 485918004907 active site 485918004908 phosphorylation site [posttranslational modification] 485918004909 intermolecular recognition site; other site 485918004910 dimerization interface [polypeptide binding]; other site 485918004911 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918004912 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918004913 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918004914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918004915 ATP binding site [chemical binding]; other site 485918004916 Mg2+ binding site [ion binding]; other site 485918004917 G-X-G motif; other site 485918004918 Response regulator receiver domain; Region: Response_reg; pfam00072 485918004919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918004920 active site 485918004921 phosphorylation site [posttranslational modification] 485918004922 intermolecular recognition site; other site 485918004923 dimerization interface [polypeptide binding]; other site 485918004924 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 485918004925 substrate binding pocket [chemical binding]; other site 485918004926 substrate-Mg2+ binding site; other site 485918004927 aspartate-rich region 1; other site 485918004928 aspartate-rich region 2; other site 485918004929 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 485918004930 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 485918004931 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 485918004932 active site 485918004933 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 485918004934 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 485918004935 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918004936 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918004937 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918004938 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918004939 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918004940 SusD family; Region: SusD; pfam07980 485918004941 Pectate lyase; Region: Pec_lyase_C; cl01593 485918004942 Protein of unknown function (DUF3826); Region: DUF3826; pfam12875 485918004943 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 485918004944 Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904 485918004945 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 485918004946 active site 485918004947 BNR repeat-like domain; Region: BNR_2; pfam13088 485918004948 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 485918004949 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 485918004950 BNR repeat-like domain; Region: BNR_2; pfam13088 485918004951 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 485918004952 Asp-box motif; other site 485918004953 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 485918004954 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 485918004955 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 485918004956 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 485918004957 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 485918004958 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 485918004959 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 485918004960 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 485918004961 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 485918004962 putative pectinesterase; Region: PLN02432; cl01911 485918004963 Pectinesterase; Region: Pectinesterase; pfam01095 485918004964 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 485918004965 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 485918004966 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 485918004967 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 485918004968 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 485918004969 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 485918004970 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 485918004971 histidinol dehydrogenase; Region: hisD; TIGR00069 485918004972 NAD binding site [chemical binding]; other site 485918004973 dimerization interface [polypeptide binding]; other site 485918004974 product binding site; other site 485918004975 substrate binding site [chemical binding]; other site 485918004976 zinc binding site [ion binding]; other site 485918004977 catalytic residues [active] 485918004978 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 485918004979 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 485918004980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918004981 homodimer interface [polypeptide binding]; other site 485918004982 catalytic residue [active] 485918004983 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 485918004984 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 485918004985 active site 485918004986 motif I; other site 485918004987 motif II; other site 485918004988 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 485918004989 4-fold oligomerization interface [polypeptide binding]; other site 485918004990 putative active site pocket [active] 485918004991 metal binding residues [ion binding]; metal-binding site 485918004992 3-fold/trimer interface [polypeptide binding]; other site 485918004993 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 485918004994 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 485918004995 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 485918004996 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 485918004997 Glutamine amidotransferase class-I; Region: GATase; pfam00117 485918004998 glutamine binding [chemical binding]; other site 485918004999 catalytic triad [active] 485918005000 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 485918005001 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 485918005002 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 485918005003 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 485918005004 active site 485918005005 ribulose/triose binding site [chemical binding]; other site 485918005006 phosphate binding site [ion binding]; other site 485918005007 substrate (anthranilate) binding pocket [chemical binding]; other site 485918005008 product (indole) binding pocket [chemical binding]; other site 485918005009 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 485918005010 active site 485918005011 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 485918005012 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 485918005013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918005014 catalytic residue [active] 485918005015 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 485918005016 substrate binding site [chemical binding]; other site 485918005017 active site 485918005018 catalytic residues [active] 485918005019 heterodimer interface [polypeptide binding]; other site 485918005020 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 485918005021 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 485918005022 putative active site [active] 485918005023 oxyanion strand; other site 485918005024 catalytic triad [active] 485918005025 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918005026 Coenzyme A binding pocket [chemical binding]; other site 485918005027 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 485918005028 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 485918005029 catalytic residues [active] 485918005030 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 485918005031 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 485918005032 substrate binding site [chemical binding]; other site 485918005033 glutamase interaction surface [polypeptide binding]; other site 485918005034 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 485918005035 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 485918005036 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 485918005037 metal binding site [ion binding]; metal-binding site 485918005038 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 485918005039 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918005040 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918005041 catalytic residues [active] 485918005042 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 485918005043 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918005044 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918005045 catalytic residues [active] 485918005046 Penicillinase repressor; Region: Pencillinase_R; pfam03965 485918005047 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 485918005048 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918005049 Uncharacterized conserved protein [Function unknown]; Region: COG1262 485918005050 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 485918005051 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 485918005052 beta-galactosidase; Region: BGL; TIGR03356 485918005053 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 485918005054 Galactose oxidase, central domain; Region: Kelch_3; cl02701 485918005055 Galactose oxidase, central domain; Region: Kelch_3; cl02701 485918005056 Histidine kinase; Region: His_kinase; pfam06580 485918005057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 485918005058 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918005059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918005060 active site 485918005061 phosphorylation site [posttranslational modification] 485918005062 intermolecular recognition site; other site 485918005063 dimerization interface [polypeptide binding]; other site 485918005064 LytTr DNA-binding domain; Region: LytTR; smart00850 485918005065 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 485918005066 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 485918005067 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 485918005068 catalytic residue [active] 485918005069 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 485918005070 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 485918005071 active site 485918005072 substrate binding site [chemical binding]; other site 485918005073 metal binding site [ion binding]; metal-binding site 485918005074 Sulfatase; Region: Sulfatase; cl17466 485918005075 Methyltransferase domain; Region: Methyltransf_31; pfam13847 485918005076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918005077 S-adenosylmethionine binding site [chemical binding]; other site 485918005078 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 485918005079 active site 485918005080 ZIP Zinc transporter; Region: Zip; pfam02535 485918005081 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 485918005082 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 485918005083 Domain of unknown function DUF21; Region: DUF21; pfam01595 485918005084 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 485918005085 Transporter associated domain; Region: CorC_HlyC; smart01091 485918005086 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 485918005087 active sites [active] 485918005088 tetramer interface [polypeptide binding]; other site 485918005089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918005090 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 485918005091 NAD(P) binding site [chemical binding]; other site 485918005092 active site 485918005093 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 485918005094 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 485918005095 dimer interface [polypeptide binding]; other site 485918005096 active site 485918005097 Phosphopantetheine attachment site; Region: PP-binding; cl09936 485918005098 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 485918005099 putative acyl-acceptor binding pocket; other site 485918005100 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 485918005101 active site 2 [active] 485918005102 active site 1 [active] 485918005103 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 485918005104 active site 485918005105 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 485918005106 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 485918005107 dimer interface [polypeptide binding]; other site 485918005108 active site 485918005109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918005110 S-adenosylmethionine binding site [chemical binding]; other site 485918005111 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 485918005112 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 485918005113 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 485918005114 Phosphopantetheine attachment site; Region: PP-binding; cl09936 485918005115 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 485918005116 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 485918005117 dimer interface [polypeptide binding]; other site 485918005118 active site 485918005119 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 485918005120 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 485918005121 NodB motif; other site 485918005122 active site 485918005123 catalytic site [active] 485918005124 metal binding site [ion binding]; metal-binding site 485918005125 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 485918005126 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 485918005127 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 485918005128 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 485918005129 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 485918005130 Ligand binding site; other site 485918005131 Putative Catalytic site; other site 485918005132 DXD motif; other site 485918005133 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 485918005134 Predicted exporter [General function prediction only]; Region: COG4258 485918005135 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 485918005136 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 485918005137 putative acyl-acceptor binding pocket; other site 485918005138 Methyltransferase domain; Region: Methyltransf_31; pfam13847 485918005139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918005140 S-adenosylmethionine binding site [chemical binding]; other site 485918005141 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 485918005142 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 485918005143 hydroxyglutarate oxidase; Provisional; Region: PRK11728 485918005144 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 485918005145 active site 485918005146 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 485918005147 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 485918005148 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 485918005149 acyl-activating enzyme (AAE) consensus motif; other site 485918005150 AMP binding site [chemical binding]; other site 485918005151 active site 485918005152 CoA binding site [chemical binding]; other site 485918005153 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 485918005154 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 485918005155 Zn binding site [ion binding]; other site 485918005156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 485918005157 TrbC/VIRB2 family; Region: TrbC; cl01583 485918005158 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 485918005159 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 485918005160 Putative esterase; Region: Esterase; pfam00756 485918005161 S-formylglutathione hydrolase; Region: PLN02442 485918005162 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 485918005163 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918005164 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918005165 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918005166 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918005167 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918005168 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 485918005169 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918005170 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918005171 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918005172 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918005173 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918005174 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918005175 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918005176 FecR protein; Region: FecR; pfam04773 485918005177 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918005178 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918005179 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918005180 DNA binding residues [nucleotide binding] 485918005181 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918005182 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918005183 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918005184 Transcriptional regulators [Transcription]; Region: PurR; COG1609 485918005185 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 485918005186 DNA binding site [nucleotide binding] 485918005187 domain linker motif; other site 485918005188 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 485918005189 dimerization interface [polypeptide binding]; other site 485918005190 ligand binding site [chemical binding]; other site 485918005191 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918005192 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918005193 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918005194 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918005195 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 485918005196 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918005197 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 485918005198 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918005199 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 485918005200 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918005201 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918005202 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918005203 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918005204 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 485918005205 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918005206 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 485918005207 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 485918005208 MutS domain I; Region: MutS_I; pfam01624 485918005209 MutS domain II; Region: MutS_II; pfam05188 485918005210 MutS domain III; Region: MutS_III; pfam05192 485918005211 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 485918005212 Walker A/P-loop; other site 485918005213 ATP binding site [chemical binding]; other site 485918005214 Q-loop/lid; other site 485918005215 ABC transporter signature motif; other site 485918005216 Walker B; other site 485918005217 D-loop; other site 485918005218 H-loop/switch region; other site 485918005219 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 485918005220 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 485918005221 UbiA prenyltransferase family; Region: UbiA; pfam01040 485918005222 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 485918005223 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 485918005224 active site 485918005225 catalytic residues [active] 485918005226 metal binding site [ion binding]; metal-binding site 485918005227 RNA polymerase sigma factor; Provisional; Region: PRK12519 485918005228 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918005229 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918005230 DNA binding residues [nucleotide binding] 485918005231 putative anti-sigmaE protein; Provisional; Region: PRK13920 485918005232 Anti-sigma-K factor rskA; Region: RskA; pfam10099 485918005233 RNA polymerase sigma factor; Provisional; Region: PRK12519 485918005234 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918005235 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918005236 DNA binding residues [nucleotide binding] 485918005237 Anti-sigma-K factor rskA; Region: RskA; pfam10099 485918005238 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918005239 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 485918005240 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 485918005241 RNA binding surface [nucleotide binding]; other site 485918005242 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 485918005243 active site 485918005244 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 485918005245 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 485918005246 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 485918005247 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 485918005248 catalytic residue [active] 485918005249 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 485918005250 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 485918005251 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 485918005252 active site 485918005253 Fn3 associated; Region: Fn3_assoc; pfam13287 485918005254 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 485918005255 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 485918005256 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 485918005257 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 485918005258 active site 485918005259 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 485918005260 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 485918005261 homodimer interface [polypeptide binding]; other site 485918005262 substrate-cofactor binding pocket; other site 485918005263 catalytic residue [active] 485918005264 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 485918005265 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 485918005266 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 485918005267 PYR/PP interface [polypeptide binding]; other site 485918005268 dimer interface [polypeptide binding]; other site 485918005269 TPP binding site [chemical binding]; other site 485918005270 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 485918005271 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 485918005272 TPP-binding site [chemical binding]; other site 485918005273 dimer interface [polypeptide binding]; other site 485918005274 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 485918005275 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 485918005276 putative valine binding site [chemical binding]; other site 485918005277 dimer interface [polypeptide binding]; other site 485918005278 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 485918005279 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 485918005280 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 485918005281 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 485918005282 threonine dehydratase; Validated; Region: PRK08639 485918005283 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 485918005284 tetramer interface [polypeptide binding]; other site 485918005285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918005286 catalytic residue [active] 485918005287 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 485918005288 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 485918005289 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 485918005290 putative NAD(P) binding site [chemical binding]; other site 485918005291 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 485918005292 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 485918005293 putative transporter; Provisional; Region: PRK10484 485918005294 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 485918005295 Na binding site [ion binding]; other site 485918005296 substrate binding site [chemical binding]; other site 485918005297 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 485918005298 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 485918005299 nucleotide binding site [chemical binding]; other site 485918005300 xylose isomerase; Provisional; Region: PRK05474 485918005301 xylose isomerase; Region: xylose_isom_A; TIGR02630 485918005302 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 485918005303 active site 485918005304 catalytic residues [active] 485918005305 CsbD-like; Region: CsbD; pfam05532 485918005306 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918005307 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 485918005308 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 485918005309 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 485918005310 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918005311 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 485918005312 Prephenate dehydratase; Region: PDT; pfam00800 485918005313 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 485918005314 putative L-Phe binding site [chemical binding]; other site 485918005315 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 485918005316 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 485918005317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918005318 homodimer interface [polypeptide binding]; other site 485918005319 catalytic residue [active] 485918005320 prephenate dehydrogenase; Validated; Region: PRK08507 485918005321 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 485918005322 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 485918005323 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 485918005324 Chorismate mutase type II; Region: CM_2; smart00830 485918005325 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 485918005326 active site 485918005327 dimer interface [polypeptide binding]; other site 485918005328 metal binding site [ion binding]; metal-binding site 485918005329 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 485918005330 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 485918005331 hinge; other site 485918005332 active site 485918005333 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 485918005334 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 485918005335 Tetramer interface [polypeptide binding]; other site 485918005336 active site 485918005337 FMN-binding site [chemical binding]; other site 485918005338 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 485918005339 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 485918005340 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 485918005341 Predicted acyl esterases [General function prediction only]; Region: COG2936 485918005342 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918005343 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 485918005344 Protein of unknown function (DUF419); Region: DUF419; pfam04237 485918005345 Predicted ATPases [General function prediction only]; Region: COG1106 485918005346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918005347 Walker A/P-loop; other site 485918005348 ATP binding site [chemical binding]; other site 485918005349 RloB-like protein; Region: RloB; pfam13707 485918005350 glycine dehydrogenase; Provisional; Region: PRK05367 485918005351 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 485918005352 tetramer interface [polypeptide binding]; other site 485918005353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918005354 catalytic residue [active] 485918005355 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 485918005356 tetramer interface [polypeptide binding]; other site 485918005357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918005358 catalytic residue [active] 485918005359 Flagellin N-methylase; Region: FliB; pfam03692 485918005360 enterobactin exporter EntS; Provisional; Region: PRK10489 485918005361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918005362 putative substrate translocation pore; other site 485918005363 carboxy-terminal protease; Provisional; Region: PRK11186 485918005364 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 485918005365 protein binding site [polypeptide binding]; other site 485918005366 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 485918005367 Catalytic dyad [active] 485918005368 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 485918005369 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 485918005370 DNA topoisomerase I; Provisional; Region: PRK08780 485918005371 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 485918005372 active site 485918005373 interdomain interaction site; other site 485918005374 putative metal-binding site [ion binding]; other site 485918005375 nucleotide binding site [chemical binding]; other site 485918005376 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 485918005377 domain I; other site 485918005378 DNA binding groove [nucleotide binding] 485918005379 phosphate binding site [ion binding]; other site 485918005380 domain II; other site 485918005381 domain III; other site 485918005382 nucleotide binding site [chemical binding]; other site 485918005383 catalytic site [active] 485918005384 domain IV; other site 485918005385 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 485918005386 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 485918005387 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 485918005388 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 485918005389 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 485918005390 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 485918005391 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 485918005392 active site 485918005393 motif I; other site 485918005394 motif II; other site 485918005395 prenyltransferase; Reviewed; Region: ubiA; PRK12872 485918005396 UbiA prenyltransferase family; Region: UbiA; pfam01040 485918005397 Maf-like protein; Region: Maf; pfam02545 485918005398 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 485918005399 active site 485918005400 dimer interface [polypeptide binding]; other site 485918005401 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 485918005402 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 485918005403 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918005404 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918005405 catalytic residues [active] 485918005406 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 485918005407 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 485918005408 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 485918005409 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 485918005410 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 485918005411 homodimer interface [polypeptide binding]; other site 485918005412 substrate-cofactor binding pocket; other site 485918005413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918005414 catalytic residue [active] 485918005415 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 485918005416 lipoyl synthase; Provisional; Region: PRK05481 485918005417 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 485918005418 FeS/SAM binding site; other site 485918005419 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 485918005420 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918005421 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 485918005422 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918005423 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 485918005424 Protein export membrane protein; Region: SecD_SecF; cl14618 485918005425 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 485918005426 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 485918005427 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 485918005428 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918005429 NAD(P) binding site [chemical binding]; other site 485918005430 active site 485918005431 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 485918005432 ATP cone domain; Region: ATP-cone; pfam03477 485918005433 Class I ribonucleotide reductase; Region: RNR_I; cd01679 485918005434 active site 485918005435 dimer interface [polypeptide binding]; other site 485918005436 catalytic residues [active] 485918005437 effector binding site; other site 485918005438 R2 peptide binding site; other site 485918005439 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 485918005440 dimer interface [polypeptide binding]; other site 485918005441 putative radical transfer pathway; other site 485918005442 diiron center [ion binding]; other site 485918005443 tyrosyl radical; other site 485918005444 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13540 485918005445 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918005446 Walker A/P-loop; other site 485918005447 ATP binding site [chemical binding]; other site 485918005448 Q-loop/lid; other site 485918005449 ABC transporter signature motif; other site 485918005450 Walker B; other site 485918005451 D-loop; other site 485918005452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 485918005453 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 485918005454 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 485918005455 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 485918005456 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 485918005457 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 485918005458 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 485918005459 substrate binding site [chemical binding]; other site 485918005460 ligand binding site [chemical binding]; other site 485918005461 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 485918005462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918005463 S-adenosylmethionine binding site [chemical binding]; other site 485918005464 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 485918005465 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 485918005466 substrate binding site [chemical binding]; other site 485918005467 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 485918005468 tartrate dehydrogenase; Region: TTC; TIGR02089 485918005469 2-isopropylmalate synthase; Validated; Region: PRK00915 485918005470 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 485918005471 active site 485918005472 catalytic residues [active] 485918005473 metal binding site [ion binding]; metal-binding site 485918005474 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 485918005475 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 485918005476 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 485918005477 classical (c) SDRs; Region: SDR_c; cd05233 485918005478 NAD(P) binding site [chemical binding]; other site 485918005479 active site 485918005480 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 485918005481 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 485918005482 Domain of unknown function (DUF718); Region: DUF718; pfam05336 485918005483 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 485918005484 Amidohydrolase; Region: Amidohydro_2; pfam04909 485918005485 active site 485918005486 short chain dehydrogenase; Provisional; Region: PRK08628 485918005487 classical (c) SDRs; Region: SDR_c; cd05233 485918005488 NAD(P) binding site [chemical binding]; other site 485918005489 active site 485918005490 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 485918005491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918005492 putative substrate translocation pore; other site 485918005493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918005494 S-adenosylmethionine binding site [chemical binding]; other site 485918005495 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 485918005496 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 485918005497 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 485918005498 putative trimer interface [polypeptide binding]; other site 485918005499 putative CoA binding site [chemical binding]; other site 485918005500 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 485918005501 putative trimer interface [polypeptide binding]; other site 485918005502 putative CoA binding site [chemical binding]; other site 485918005503 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 485918005504 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 485918005505 glutaminase active site [active] 485918005506 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 485918005507 dimer interface [polypeptide binding]; other site 485918005508 active site 485918005509 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 485918005510 dimer interface [polypeptide binding]; other site 485918005511 active site 485918005512 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 485918005513 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 485918005514 MgtE intracellular N domain; Region: MgtE_N; pfam03448 485918005515 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 485918005516 Divalent cation transporter; Region: MgtE; pfam01769 485918005517 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 485918005518 SET domain; Region: SET; pfam00856 485918005519 MarR family; Region: MarR_2; pfam12802 485918005520 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 485918005521 active sites [active] 485918005522 tetramer interface [polypeptide binding]; other site 485918005523 urocanate hydratase; Provisional; Region: PRK05414 485918005524 imidazolonepropionase; Validated; Region: PRK09356 485918005525 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 485918005526 active site 485918005527 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 485918005528 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 485918005529 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918005530 formimidoylglutamase; Provisional; Region: PRK13775 485918005531 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 485918005532 putative active site [active] 485918005533 putative metal binding site [ion binding]; other site 485918005534 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 485918005535 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 485918005536 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 485918005537 putative active site [active] 485918005538 putative substrate binding site [chemical binding]; other site 485918005539 putative cosubstrate binding site; other site 485918005540 catalytic site [active] 485918005541 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 485918005542 active site 485918005543 metal binding site [ion binding]; metal-binding site 485918005544 homotetramer interface [polypeptide binding]; other site 485918005545 Domain of unknown function (DUF4421); Region: DUF4421; pfam14391 485918005546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 485918005547 aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340 485918005548 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584 485918005549 substrate binding site [chemical binding]; other site 485918005550 ligand binding site [chemical binding]; other site 485918005551 Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes...; Region: AcnA_Mitochon_Swivel; cd01578 485918005552 substrate binding site [chemical binding]; other site 485918005553 PspC domain; Region: PspC; cl00864 485918005554 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 485918005555 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 485918005556 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 485918005557 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918005558 NAD(P) binding site [chemical binding]; other site 485918005559 active site 485918005560 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918005561 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918005562 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 485918005563 active site triad [active] 485918005564 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 485918005565 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 485918005566 CysD dimerization site [polypeptide binding]; other site 485918005567 G1 box; other site 485918005568 putative GEF interaction site [polypeptide binding]; other site 485918005569 GTP/Mg2+ binding site [chemical binding]; other site 485918005570 Switch I region; other site 485918005571 G2 box; other site 485918005572 G3 box; other site 485918005573 Switch II region; other site 485918005574 G4 box; other site 485918005575 G5 box; other site 485918005576 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 485918005577 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 485918005578 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 485918005579 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 485918005580 Active Sites [active] 485918005581 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 485918005582 Active Sites [active] 485918005583 Rrf2 family protein; Region: rrf2_super; TIGR00738 485918005584 Transcriptional regulator; Region: Rrf2; pfam02082 485918005585 dihydrodipicolinate reductase; Provisional; Region: PRK00048 485918005586 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 485918005587 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 485918005588 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 485918005589 ParB-like nuclease domain; Region: ParBc; pfam02195 485918005590 KorB domain; Region: KorB; pfam08535 485918005591 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 485918005592 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 485918005593 P-loop; other site 485918005594 Magnesium ion binding site [ion binding]; other site 485918005595 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 485918005596 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 485918005597 phosphodiesterase YaeI; Provisional; Region: PRK11340 485918005598 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 485918005599 putative active site [active] 485918005600 putative metal binding site [ion binding]; other site 485918005601 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 485918005602 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 485918005603 Found in ATP-dependent protease La (LON); Region: LON; smart00464 485918005604 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918005605 Walker A motif; other site 485918005606 ATP binding site [chemical binding]; other site 485918005607 Walker B motif; other site 485918005608 arginine finger; other site 485918005609 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 485918005610 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 485918005611 active site 485918005612 hydrophilic channel; other site 485918005613 dimerization interface [polypeptide binding]; other site 485918005614 catalytic residues [active] 485918005615 active site lid [active] 485918005616 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 485918005617 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 485918005618 homotetramer interface [polypeptide binding]; other site 485918005619 ligand binding site [chemical binding]; other site 485918005620 catalytic site [active] 485918005621 NAD binding site [chemical binding]; other site 485918005622 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 485918005623 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918005624 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 485918005625 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 485918005626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918005627 Coenzyme A binding pocket [chemical binding]; other site 485918005628 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 485918005629 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 485918005630 catalytic residues [active] 485918005631 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 485918005632 hypothetical protein; Provisional; Region: PRK08609 485918005633 metal binding triad [ion binding]; metal-binding site 485918005634 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 485918005635 active site 485918005636 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 485918005637 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 485918005638 GH3 auxin-responsive promoter; Region: GH3; pfam03321 485918005639 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 485918005640 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 485918005641 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 485918005642 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 485918005643 RIP metalloprotease RseP; Region: TIGR00054 485918005644 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 485918005645 active site 485918005646 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 485918005647 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 485918005648 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 485918005649 putative substrate binding region [chemical binding]; other site 485918005650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918005651 ATP binding site [chemical binding]; other site 485918005652 Mg2+ binding site [ion binding]; other site 485918005653 G-X-G motif; other site 485918005654 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 485918005655 Mechanosensitive ion channel; Region: MS_channel; pfam00924 485918005656 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 485918005657 Domain of unknown function (DUF4421); Region: DUF4421; pfam14391 485918005658 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 485918005659 HipA-like N-terminal domain; Region: HipA_N; pfam07805 485918005660 HipA-like C-terminal domain; Region: HipA_C; pfam07804 485918005661 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 485918005662 non-specific DNA binding site [nucleotide binding]; other site 485918005663 salt bridge; other site 485918005664 sequence-specific DNA binding site [nucleotide binding]; other site 485918005665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918005666 Response regulator receiver domain; Region: Response_reg; pfam00072 485918005667 active site 485918005668 phosphorylation site [posttranslational modification] 485918005669 intermolecular recognition site; other site 485918005670 dimerization interface [polypeptide binding]; other site 485918005671 LytTr DNA-binding domain; Region: LytTR; smart00850 485918005672 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 485918005673 Histidine kinase; Region: His_kinase; pfam06580 485918005674 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918005675 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918005676 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918005677 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 485918005678 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 485918005679 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918005680 NAD(P) binding site [chemical binding]; other site 485918005681 active site 485918005682 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 485918005683 FMN binding site [chemical binding]; other site 485918005684 dimer interface [polypeptide binding]; other site 485918005685 Uncharacterized conserved protein [Function unknown]; Region: COG1359 485918005686 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918005687 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918005688 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 485918005689 AAA ATPase domain; Region: AAA_16; pfam13191 485918005690 DEAD-like helicases superfamily; Region: DEXDc; smart00487 485918005691 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 485918005692 ATP binding site [chemical binding]; other site 485918005693 putative Mg++ binding site [ion binding]; other site 485918005694 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 485918005695 nucleotide binding region [chemical binding]; other site 485918005696 ATP-binding site [chemical binding]; other site 485918005697 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 485918005698 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 485918005699 Aconitate hydratase 2 N-terminus; Region: Aconitase_2_N; pfam06434 485918005700 substrate binding site [chemical binding]; other site 485918005701 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 485918005702 substrate binding site [chemical binding]; other site 485918005703 ligand binding site [chemical binding]; other site 485918005704 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 485918005705 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 485918005706 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918005707 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918005708 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918005709 DNA binding residues [nucleotide binding] 485918005710 FecR protein; Region: FecR; pfam04773 485918005711 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918005712 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918005713 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918005714 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918005715 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918005716 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918005717 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 485918005718 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918005719 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918005720 catalytic residues [active] 485918005721 LytTr DNA-binding domain; Region: LytTR; pfam04397 485918005722 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 485918005723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918005724 active site 485918005725 phosphorylation site [posttranslational modification] 485918005726 intermolecular recognition site; other site 485918005727 dimerization interface [polypeptide binding]; other site 485918005728 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918005729 Walker A motif; other site 485918005730 ATP binding site [chemical binding]; other site 485918005731 Walker B motif; other site 485918005732 arginine finger; other site 485918005733 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918005734 binding surface 485918005735 TPR motif; other site 485918005736 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918005737 Selenoprotein S (SelS); Region: Selenoprotein_S; pfam06936 485918005738 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 485918005739 Histidine kinase; Region: HisKA_2; pfam07568 485918005740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918005741 ATP binding site [chemical binding]; other site 485918005742 Mg2+ binding site [ion binding]; other site 485918005743 G-X-G motif; other site 485918005744 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 485918005745 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 485918005746 NAD binding site [chemical binding]; other site 485918005747 catalytic residues [active] 485918005748 HopJ type III effector protein; Region: HopJ; pfam08888 485918005749 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 485918005750 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 485918005751 dimerization interface [polypeptide binding]; other site 485918005752 ATP binding site [chemical binding]; other site 485918005753 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 485918005754 dimerization interface [polypeptide binding]; other site 485918005755 ATP binding site [chemical binding]; other site 485918005756 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 485918005757 putative active site [active] 485918005758 catalytic triad [active] 485918005759 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 485918005760 ATP binding site [chemical binding]; other site 485918005761 Mg2+ binding site [ion binding]; other site 485918005762 G-X-G motif; other site 485918005763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918005764 NmrA-like family; Region: NmrA; pfam05368 485918005765 NAD(P) binding site [chemical binding]; other site 485918005766 active site 485918005767 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918005768 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918005769 FecR protein; Region: FecR; pfam04773 485918005770 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918005771 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 485918005772 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918005773 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918005774 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918005775 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918005776 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918005777 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918005778 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 485918005779 pentamer interface [polypeptide binding]; other site 485918005780 dodecaamer interface [polypeptide binding]; other site 485918005781 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918005782 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918005783 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918005784 binding surface 485918005785 TPR motif; other site 485918005786 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918005787 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918005788 Histidine kinase; Region: HisKA_3; pfam07730 485918005789 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 485918005790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918005791 ATP binding site [chemical binding]; other site 485918005792 Mg2+ binding site [ion binding]; other site 485918005793 G-X-G motif; other site 485918005794 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918005795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918005796 active site 485918005797 phosphorylation site [posttranslational modification] 485918005798 intermolecular recognition site; other site 485918005799 dimerization interface [polypeptide binding]; other site 485918005800 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918005801 DNA binding residues [nucleotide binding] 485918005802 dimerization interface [polypeptide binding]; other site 485918005803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 485918005804 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 485918005805 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918005806 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918005807 catalytic residues [active] 485918005808 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918005809 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918005810 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 485918005811 DNA binding residues [nucleotide binding] 485918005812 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918005813 FecR protein; Region: FecR; pfam04773 485918005814 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918005815 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918005816 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918005817 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918005818 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918005819 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918005820 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918005821 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 485918005822 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918005823 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918005824 catalytic residues [active] 485918005825 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 485918005826 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918005827 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918005828 catalytic residues [active] 485918005829 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 485918005830 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 485918005831 active site 485918005832 HEAT repeats; Region: HEAT_2; pfam13646 485918005833 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 485918005834 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 485918005835 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 485918005836 N-terminal plug; other site 485918005837 ligand-binding site [chemical binding]; other site 485918005838 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 485918005839 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 485918005840 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 485918005841 active site 485918005842 metal binding site [ion binding]; metal-binding site 485918005843 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 485918005844 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 485918005845 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 485918005846 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 485918005847 putative sugar binding sites [chemical binding]; other site 485918005848 Q-X-W motif; other site 485918005849 TraB family; Region: TraB; pfam01963 485918005850 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 485918005851 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 485918005852 hydrophobic ligand binding site; other site 485918005853 Rifin/stevor family; Region: Rifin_STEVOR; cl14106 485918005854 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 485918005855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918005856 NAD(P) binding site [chemical binding]; other site 485918005857 active site 485918005858 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 485918005859 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 485918005860 dinuclear metal binding motif [ion binding]; other site 485918005861 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 485918005862 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918005863 binding surface 485918005864 TPR motif; other site 485918005865 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918005866 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 485918005867 Histidine kinase; Region: HisKA_3; pfam07730 485918005868 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918005869 ATP binding site [chemical binding]; other site 485918005870 Mg2+ binding site [ion binding]; other site 485918005871 G-X-G motif; other site 485918005872 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918005873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918005874 active site 485918005875 phosphorylation site [posttranslational modification] 485918005876 intermolecular recognition site; other site 485918005877 dimerization interface [polypeptide binding]; other site 485918005878 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918005879 DNA binding residues [nucleotide binding] 485918005880 dimerization interface [polypeptide binding]; other site 485918005881 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375 485918005882 active site 485918005883 Zn binding site [ion binding]; other site 485918005884 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918005885 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 485918005886 DNA binding residues [nucleotide binding] 485918005887 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918005888 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918005889 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918005890 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918005891 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 485918005892 dimer interface [polypeptide binding]; other site 485918005893 putative metal binding site [ion binding]; other site 485918005894 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918005895 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918005896 Cytosol aminopeptidase family, N-terminal domain; Region: Peptidase_M17_N; pfam02789 485918005897 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 485918005898 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 485918005899 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 485918005900 dimerization interface [polypeptide binding]; other site 485918005901 DPS ferroxidase diiron center [ion binding]; other site 485918005902 ion pore; other site 485918005903 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 485918005904 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 485918005905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918005906 homodimer interface [polypeptide binding]; other site 485918005907 catalytic residue [active] 485918005908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918005909 Major Facilitator Superfamily; Region: MFS_1; pfam07690 485918005910 putative substrate translocation pore; other site 485918005911 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 485918005912 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 485918005913 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 485918005914 NAD(P) binding site [chemical binding]; other site 485918005915 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 485918005916 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 485918005917 inhibitor-cofactor binding pocket; inhibition site 485918005918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918005919 catalytic residue [active] 485918005920 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 485918005921 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 485918005922 catalytic loop [active] 485918005923 iron binding site [ion binding]; other site 485918005924 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 485918005925 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 485918005926 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 485918005927 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 485918005928 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 485918005929 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 485918005930 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 485918005931 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 485918005932 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 485918005933 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 485918005934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918005935 Walker A/P-loop; other site 485918005936 ATP binding site [chemical binding]; other site 485918005937 Q-loop/lid; other site 485918005938 ABC transporter signature motif; other site 485918005939 Walker B; other site 485918005940 D-loop; other site 485918005941 H-loop/switch region; other site 485918005942 TOBE domain; Region: TOBE_2; pfam08402 485918005943 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 485918005944 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 485918005945 Family description; Region: UvrD_C_2; pfam13538 485918005946 Response regulator receiver domain; Region: Response_reg; pfam00072 485918005947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918005948 active site 485918005949 phosphorylation site [posttranslational modification] 485918005950 intermolecular recognition site; other site 485918005951 dimerization interface [polypeptide binding]; other site 485918005952 CHASE3 domain; Region: CHASE3; cl05000 485918005953 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918005954 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 485918005955 dimerization interface [polypeptide binding]; other site 485918005956 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918005957 dimer interface [polypeptide binding]; other site 485918005958 phosphorylation site [posttranslational modification] 485918005959 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918005960 ATP binding site [chemical binding]; other site 485918005961 Mg2+ binding site [ion binding]; other site 485918005962 G-X-G motif; other site 485918005963 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 485918005964 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 485918005965 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 485918005966 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 485918005967 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 485918005968 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 485918005969 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 485918005970 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 485918005971 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 485918005972 AAA domain; Region: AAA_30; pfam13604 485918005973 Family description; Region: UvrD_C_2; pfam13538 485918005974 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 485918005975 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 485918005976 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 485918005977 Part of AAA domain; Region: AAA_19; pfam13245 485918005978 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 485918005979 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 485918005980 dimer interface [polypeptide binding]; other site 485918005981 active site 485918005982 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 485918005983 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 485918005984 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 485918005985 active site 485918005986 Na/Ca binding site [ion binding]; other site 485918005987 catalytic site [active] 485918005988 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 485918005989 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 485918005990 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 485918005991 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918005992 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918005993 ligand binding site [chemical binding]; other site 485918005994 flexible hinge region; other site 485918005995 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 485918005996 Uncharacterized conserved protein [Function unknown]; Region: COG2128 485918005997 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918005998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918005999 active site 485918006000 phosphorylation site [posttranslational modification] 485918006001 intermolecular recognition site; other site 485918006002 dimerization interface [polypeptide binding]; other site 485918006003 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918006004 dimerization interface [polypeptide binding]; other site 485918006005 DNA binding residues [nucleotide binding] 485918006006 Domain of unknown function DUF11; Region: DUF11; pfam01345 485918006007 Domain of unknown function DUF11; Region: DUF11; pfam01345 485918006008 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918006009 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 485918006010 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 485918006011 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918006012 TPR motif; other site 485918006013 binding surface 485918006014 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 485918006015 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 485918006016 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 485918006017 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 485918006018 ligand binding site [chemical binding]; other site 485918006019 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 485918006020 active site 485918006021 Glyco_18 domain; Region: Glyco_18; smart00636 485918006022 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 485918006023 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 485918006024 putative active site [active] 485918006025 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 485918006026 aromatic chitin/cellulose binding site residues [chemical binding]; other site 485918006027 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 485918006028 aromatic chitin/cellulose binding site residues [chemical binding]; other site 485918006029 Beta/Gamma crystallin; Region: Crystall; cl02528 485918006030 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918006031 Glyco_18 domain; Region: Glyco_18; smart00636 485918006032 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 485918006033 active site 485918006034 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 485918006035 Ca binding site [ion binding]; other site 485918006036 ligand binding site I [chemical binding]; other site 485918006037 homodimer interface [polypeptide binding]; other site 485918006038 ligand binding site II [chemical binding]; other site 485918006039 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918006040 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 485918006041 active site 485918006042 catalytic residues [active] 485918006043 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 485918006044 Ca binding site [ion binding]; other site 485918006045 ligand binding site I [chemical binding]; other site 485918006046 homodimer interface [polypeptide binding]; other site 485918006047 ligand binding site II [chemical binding]; other site 485918006048 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 485918006049 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 485918006050 Beta/Gamma crystallin; Region: Crystall; cl02528 485918006051 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918006052 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918006053 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918006054 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918006055 DNA binding residues [nucleotide binding] 485918006056 FecR protein; Region: FecR; pfam04773 485918006057 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918006058 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918006059 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918006060 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918006061 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918006062 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918006063 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918006064 Domain of unknown function (DUF4302); Region: DUF4302; pfam14135 485918006065 Right handed beta helix region; Region: Beta_helix; pfam13229 485918006066 Right handed beta helix region; Region: Beta_helix; pfam13229 485918006067 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 485918006068 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918006069 FOG: PKD repeat [General function prediction only]; Region: COG3291 485918006070 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918006071 PKD domain; Region: PKD; pfam00801 485918006072 FOG: PKD repeat [General function prediction only]; Region: COG3291 485918006073 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918006074 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918006075 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 485918006076 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 485918006077 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918006078 binding surface 485918006079 TPR motif; other site 485918006080 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 485918006081 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 485918006082 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 485918006083 ligand binding site [chemical binding]; other site 485918006084 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 485918006085 RNA polymerase sigma factor; Provisional; Region: PRK12513 485918006086 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918006087 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918006088 DNA binding residues [nucleotide binding] 485918006089 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918006090 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 485918006091 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 485918006092 putative active site; other site 485918006093 catalytic residue [active] 485918006094 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918006095 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918006096 catalytic residues [active] 485918006097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 485918006098 Histidine kinase; Region: HisKA_2; pfam07568 485918006099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918006100 ATP binding site [chemical binding]; other site 485918006101 Mg2+ binding site [ion binding]; other site 485918006102 G-X-G motif; other site 485918006103 Response regulator receiver domain; Region: Response_reg; pfam00072 485918006104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918006105 active site 485918006106 phosphorylation site [posttranslational modification] 485918006107 intermolecular recognition site; other site 485918006108 dimerization interface [polypeptide binding]; other site 485918006109 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 485918006110 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918006111 Walker A motif; other site 485918006112 ATP binding site [chemical binding]; other site 485918006113 Walker B motif; other site 485918006114 arginine finger; other site 485918006115 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 485918006116 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 485918006117 putative NAD(P) binding site [chemical binding]; other site 485918006118 putative substrate binding site [chemical binding]; other site 485918006119 catalytic Zn binding site [ion binding]; other site 485918006120 structural Zn binding site [ion binding]; other site 485918006121 dimer interface [polypeptide binding]; other site 485918006122 DinB family; Region: DinB; cl17821 485918006123 short chain dehydrogenase; Provisional; Region: PRK06180 485918006124 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918006125 NADP binding site [chemical binding]; other site 485918006126 active site 485918006127 steroid binding site; other site 485918006128 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918006129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918006130 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918006131 LytTr DNA-binding domain; Region: LytTR; smart00850 485918006132 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 485918006133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918006134 S-adenosylmethionine binding site [chemical binding]; other site 485918006135 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 485918006136 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 485918006137 catalytic motif [active] 485918006138 Zn binding site [ion binding]; other site 485918006139 RibD C-terminal domain; Region: RibD_C; pfam01872 485918006140 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 485918006141 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 485918006142 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 485918006143 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 485918006144 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 485918006145 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918006146 antiporter inner membrane protein; Provisional; Region: PRK11670 485918006147 Domain of unknown function DUF59; Region: DUF59; pfam01883 485918006148 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 485918006149 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 485918006150 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 485918006151 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 485918006152 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 485918006153 active site 485918006154 dimer interface [polypeptide binding]; other site 485918006155 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 485918006156 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 485918006157 active site 485918006158 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 485918006159 ApbE family; Region: ApbE; pfam02424 485918006160 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 485918006161 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 485918006162 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 485918006163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 485918006164 motif II; other site 485918006165 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 485918006166 short chain dehydrogenase; Provisional; Region: PRK06180 485918006167 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918006168 NADP binding site [chemical binding]; other site 485918006169 active site 485918006170 steroid binding site; other site 485918006171 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918006172 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918006173 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 485918006174 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 485918006175 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 485918006176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 485918006177 dimer interface [polypeptide binding]; other site 485918006178 conserved gate region; other site 485918006179 putative PBP binding loops; other site 485918006180 ABC-ATPase subunit interface; other site 485918006181 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918006182 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 485918006183 Walker A/P-loop; other site 485918006184 ATP binding site [chemical binding]; other site 485918006185 Q-loop/lid; other site 485918006186 ABC transporter signature motif; other site 485918006187 Walker B; other site 485918006188 D-loop; other site 485918006189 H-loop/switch region; other site 485918006190 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 485918006191 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 485918006192 active site 485918006193 catalytic site [active] 485918006194 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918006195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918006196 ATP binding site [chemical binding]; other site 485918006197 Mg2+ binding site [ion binding]; other site 485918006198 G-X-G motif; other site 485918006199 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 485918006200 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 485918006201 Probable Catalytic site; other site 485918006202 metal-binding site 485918006203 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 485918006204 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 485918006205 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918006206 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918006207 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 485918006208 N-terminal plug; other site 485918006209 ligand-binding site [chemical binding]; other site 485918006210 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 485918006211 TPR repeat; Region: TPR_11; pfam13414 485918006212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918006213 binding surface 485918006214 TPR motif; other site 485918006215 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918006216 binding surface 485918006217 TPR motif; other site 485918006218 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918006219 TPR motif; other site 485918006220 TPR repeat; Region: TPR_11; pfam13414 485918006221 binding surface 485918006222 Tetratricopeptide repeat; Region: TPR_16; pfam13432 485918006223 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918006224 TPR motif; other site 485918006225 binding surface 485918006226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918006227 binding surface 485918006228 TPR motif; other site 485918006229 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 485918006230 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 485918006231 DXD motif; other site 485918006232 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 485918006233 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 485918006234 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 485918006235 DXD motif; other site 485918006236 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 485918006237 HEAT repeats; Region: HEAT_2; pfam13646 485918006238 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 485918006239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918006240 active site 485918006241 phosphorylation site [posttranslational modification] 485918006242 intermolecular recognition site; other site 485918006243 dimerization interface [polypeptide binding]; other site 485918006244 CHASE3 domain; Region: CHASE3; pfam05227 485918006245 GAF domain; Region: GAF_3; pfam13492 485918006246 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918006247 dimer interface [polypeptide binding]; other site 485918006248 phosphorylation site [posttranslational modification] 485918006249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918006250 ATP binding site [chemical binding]; other site 485918006251 Mg2+ binding site [ion binding]; other site 485918006252 G-X-G motif; other site 485918006253 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 485918006254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918006255 active site 485918006256 phosphorylation site [posttranslational modification] 485918006257 intermolecular recognition site; other site 485918006258 dimerization interface [polypeptide binding]; other site 485918006259 Response regulator receiver domain; Region: Response_reg; pfam00072 485918006260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918006261 active site 485918006262 phosphorylation site [posttranslational modification] 485918006263 intermolecular recognition site; other site 485918006264 dimerization interface [polypeptide binding]; other site 485918006265 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 485918006266 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 485918006267 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 485918006268 CheB methylesterase; Region: CheB_methylest; pfam01339 485918006269 Response regulator receiver domain; Region: Response_reg; pfam00072 485918006270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918006271 active site 485918006272 phosphorylation site [posttranslational modification] 485918006273 intermolecular recognition site; other site 485918006274 dimerization interface [polypeptide binding]; other site 485918006275 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918006276 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918006277 dimer interface [polypeptide binding]; other site 485918006278 phosphorylation site [posttranslational modification] 485918006279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918006280 ATP binding site [chemical binding]; other site 485918006281 Mg2+ binding site [ion binding]; other site 485918006282 G-X-G motif; other site 485918006283 FecR protein; Region: FecR; pfam04773 485918006284 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918006285 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918006286 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 485918006287 DNA binding residues [nucleotide binding] 485918006288 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918006289 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918006290 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918006291 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918006292 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918006293 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918006294 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918006295 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918006296 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918006297 catalytic residues [active] 485918006298 Protein of unknown function (DUF3738); Region: DUF3738; pfam12543 485918006299 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918006300 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918006301 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 485918006302 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 485918006303 HEAT repeats; Region: HEAT_2; pfam13646 485918006304 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 485918006305 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 485918006306 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 485918006307 putative glycosyl transferase; Provisional; Region: PRK10307 485918006308 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 485918006309 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 485918006310 Bacterial sugar transferase; Region: Bac_transf; pfam02397 485918006311 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 485918006312 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 485918006313 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 485918006314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918006315 Methyltransferase domain; Region: Methyltransf_23; pfam13489 485918006316 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 485918006317 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 485918006318 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 485918006319 Chain length determinant protein; Region: Wzz; pfam02706 485918006320 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 485918006321 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 485918006322 AAA domain; Region: AAA_31; pfam13614 485918006323 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 485918006324 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 485918006325 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 485918006326 SLBB domain; Region: SLBB; pfam10531 485918006327 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 485918006328 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 485918006329 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 485918006330 hypothetical protein; Reviewed; Region: PRK09588 485918006331 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 485918006332 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 485918006333 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 485918006334 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 485918006335 Multicopper oxidase; Region: Cu-oxidase; pfam00394 485918006336 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 485918006337 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918006338 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918006339 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918006340 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 485918006341 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 485918006342 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 485918006343 DNA binding site [nucleotide binding] 485918006344 active site 485918006345 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 485918006346 Clp amino terminal domain; Region: Clp_N; pfam02861 485918006347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918006348 Walker A motif; other site 485918006349 ATP binding site [chemical binding]; other site 485918006350 Walker B motif; other site 485918006351 arginine finger; other site 485918006352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918006353 Walker A motif; other site 485918006354 ATP binding site [chemical binding]; other site 485918006355 Walker B motif; other site 485918006356 arginine finger; other site 485918006357 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 485918006358 Protein of unknown function (DUF877); Region: DUF877; pfam05943 485918006359 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 485918006360 N-acetyl-D-glucosamine binding site [chemical binding]; other site 485918006361 catalytic residue [active] 485918006362 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 485918006363 PKD domain; Region: PKD; pfam00801 485918006364 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 485918006365 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 485918006366 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 485918006367 YceI-like domain; Region: YceI; cl01001 485918006368 Predicted membrane protein [Function unknown]; Region: COG4270 485918006369 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918006370 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918006371 ligand binding site [chemical binding]; other site 485918006372 pantothenate kinase; Provisional; Region: PRK05439 485918006373 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 485918006374 ATP-binding site [chemical binding]; other site 485918006375 CoA-binding site [chemical binding]; other site 485918006376 Mg2+-binding site [ion binding]; other site 485918006377 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 485918006378 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 485918006379 NAD(P) binding site [chemical binding]; other site 485918006380 catalytic residues [active] 485918006381 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918006382 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918006383 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 485918006384 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 485918006385 N-terminal plug; other site 485918006386 ligand-binding site [chemical binding]; other site 485918006387 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 485918006388 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 485918006389 domain interfaces; other site 485918006390 active site 485918006391 6-phosphofructokinase; Provisional; Region: PRK03202 485918006392 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 485918006393 active site 485918006394 ADP/pyrophosphate binding site [chemical binding]; other site 485918006395 dimerization interface [polypeptide binding]; other site 485918006396 allosteric effector site; other site 485918006397 fructose-1,6-bisphosphate binding site; other site 485918006398 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 485918006399 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918006400 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 485918006401 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 485918006402 NADP binding site [chemical binding]; other site 485918006403 active site 485918006404 putative substrate binding site [chemical binding]; other site 485918006405 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918006406 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918006407 binding surface 485918006408 TPR motif; other site 485918006409 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 485918006410 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 485918006411 binding surface 485918006412 Tetratricopeptide repeat; Region: TPR_16; pfam13432 485918006413 TPR motif; other site 485918006414 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 485918006415 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918006416 binding surface 485918006417 TPR motif; other site 485918006418 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 485918006419 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918006420 binding surface 485918006421 TPR motif; other site 485918006422 Predicted membrane protein [Function unknown]; Region: COG2259 485918006423 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 485918006424 active site 485918006425 competence damage-inducible protein A; Provisional; Region: PRK00549 485918006426 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 485918006427 putative MPT binding site; other site 485918006428 Competence-damaged protein; Region: CinA; pfam02464 485918006429 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 485918006430 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 485918006431 E3 interaction surface; other site 485918006432 lipoyl attachment site [posttranslational modification]; other site 485918006433 e3 binding domain; Region: E3_binding; pfam02817 485918006434 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 485918006435 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 485918006436 Eukaryotic phosphomannomutase; Region: PMM; cl17107 485918006437 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 485918006438 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 485918006439 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918006440 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 485918006441 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918006442 EamA-like transporter family; Region: EamA; pfam00892 485918006443 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 485918006444 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 485918006445 Ligand binding site; other site 485918006446 Putative Catalytic site; other site 485918006447 DXD motif; other site 485918006448 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 485918006449 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 485918006450 active site 485918006451 catalytic site [active] 485918006452 substrate binding site [chemical binding]; other site 485918006453 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 485918006454 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 485918006455 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 485918006456 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 485918006457 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 485918006458 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 485918006459 Flavoprotein; Region: Flavoprotein; pfam02441 485918006460 Dehydroquinase class II; Region: DHquinase_II; pfam01220 485918006461 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 485918006462 trimer interface [polypeptide binding]; other site 485918006463 active site 485918006464 dimer interface [polypeptide binding]; other site 485918006465 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 485918006466 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 485918006467 oligomer interface [polypeptide binding]; other site 485918006468 active site 485918006469 metal binding site [ion binding]; metal-binding site 485918006470 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 485918006471 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 485918006472 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 485918006473 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 485918006474 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 485918006475 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 485918006476 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918006477 Response regulator receiver domain; Region: Response_reg; pfam00072 485918006478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918006479 active site 485918006480 phosphorylation site [posttranslational modification] 485918006481 intermolecular recognition site; other site 485918006482 dimerization interface [polypeptide binding]; other site 485918006483 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918006484 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918006485 dimer interface [polypeptide binding]; other site 485918006486 phosphorylation site [posttranslational modification] 485918006487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918006488 ATP binding site [chemical binding]; other site 485918006489 Mg2+ binding site [ion binding]; other site 485918006490 G-X-G motif; other site 485918006491 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918006492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918006493 active site 485918006494 phosphorylation site [posttranslational modification] 485918006495 intermolecular recognition site; other site 485918006496 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918006497 DNA binding residues [nucleotide binding] 485918006498 dimerization interface [polypeptide binding]; other site 485918006499 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 485918006500 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 485918006501 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 485918006502 Chain length determinant protein; Region: Wzz; cl15801 485918006503 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 485918006504 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 485918006505 Transcription antiterminator [Transcription]; Region: NusG; COG0250 485918006506 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 485918006507 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 485918006508 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 485918006509 Substrate binding site; other site 485918006510 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 485918006511 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 485918006512 NADP binding site [chemical binding]; other site 485918006513 active site 485918006514 putative substrate binding site [chemical binding]; other site 485918006515 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 485918006516 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 485918006517 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 485918006518 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 485918006519 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 485918006520 NADP-binding site; other site 485918006521 homotetramer interface [polypeptide binding]; other site 485918006522 substrate binding site [chemical binding]; other site 485918006523 homodimer interface [polypeptide binding]; other site 485918006524 active site 485918006525 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 485918006526 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 485918006527 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 485918006528 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 485918006529 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 485918006530 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 485918006531 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 485918006532 Acyltransferase family; Region: Acyl_transf_3; pfam01757 485918006533 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 485918006534 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 485918006535 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 485918006536 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 485918006537 putative ADP-binding pocket [chemical binding]; other site 485918006538 VanZ like family; Region: VanZ; pfam04892 485918006539 putative acyl transferase; Provisional; Region: PRK10502 485918006540 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 485918006541 putative trimer interface [polypeptide binding]; other site 485918006542 putative active site [active] 485918006543 putative substrate binding site [chemical binding]; other site 485918006544 putative CoA binding site [chemical binding]; other site 485918006545 putative glycosyl transferase; Provisional; Region: PRK10307 485918006546 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 485918006547 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 485918006548 Bacterial sugar transferase; Region: Bac_transf; pfam02397 485918006549 malate:quinone oxidoreductase; Validated; Region: PRK05257 485918006550 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 485918006551 Rubredoxin; Region: Rubredoxin; pfam00301 485918006552 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 485918006553 iron binding site [ion binding]; other site 485918006554 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 485918006555 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 485918006556 molybdopterin cofactor binding site; other site 485918006557 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 485918006558 molybdopterin cofactor binding site; other site 485918006559 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 485918006560 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 485918006561 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 485918006562 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 485918006563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918006564 putative substrate translocation pore; other site 485918006565 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 485918006566 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 485918006567 nitrite reductase subunit NirD; Provisional; Region: PRK14989 485918006568 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 485918006569 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 485918006570 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 485918006571 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 485918006572 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 485918006573 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 485918006574 active site 485918006575 SAM binding site [chemical binding]; other site 485918006576 homodimer interface [polypeptide binding]; other site 485918006577 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918006578 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918006579 ligand binding site [chemical binding]; other site 485918006580 flexible hinge region; other site 485918006581 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 485918006582 putative switch regulator; other site 485918006583 non-specific DNA interactions [nucleotide binding]; other site 485918006584 DNA binding site [nucleotide binding] 485918006585 sequence specific DNA binding site [nucleotide binding]; other site 485918006586 putative cAMP binding site [chemical binding]; other site 485918006587 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918006588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918006589 active site 485918006590 phosphorylation site [posttranslational modification] 485918006591 intermolecular recognition site; other site 485918006592 dimerization interface [polypeptide binding]; other site 485918006593 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918006594 DNA binding residues [nucleotide binding] 485918006595 dimerization interface [polypeptide binding]; other site 485918006596 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 485918006597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918006598 ATP binding site [chemical binding]; other site 485918006599 Mg2+ binding site [ion binding]; other site 485918006600 G-X-G motif; other site 485918006601 hydroperoxidase II; Provisional; Region: katE; PRK11249 485918006602 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 485918006603 tetramer interface [polypeptide binding]; other site 485918006604 heme binding pocket [chemical binding]; other site 485918006605 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 485918006606 domain interactions; other site 485918006607 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 485918006608 dimerization interface [polypeptide binding]; other site 485918006609 metal binding site [ion binding]; metal-binding site 485918006610 Protein of unknown function (DUF983); Region: DUF983; cl02211 485918006611 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 485918006612 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 485918006613 Predicted transcriptional regulators [Transcription]; Region: COG1695 485918006614 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 485918006615 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 485918006616 substrate-cofactor binding pocket; other site 485918006617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918006618 catalytic residue [active] 485918006619 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 485918006620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918006621 NAD(P) binding site [chemical binding]; other site 485918006622 active site 485918006623 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 485918006624 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 485918006625 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 485918006626 tetramer interfaces [polypeptide binding]; other site 485918006627 binuclear metal-binding site [ion binding]; other site 485918006628 Predicted membrane protein [Function unknown]; Region: COG2246 485918006629 GtrA-like protein; Region: GtrA; pfam04138 485918006630 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918006631 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 485918006632 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 485918006633 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 485918006634 active site 485918006635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918006636 TPR motif; other site 485918006637 binding surface 485918006638 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918006639 TPR repeat; Region: TPR_11; pfam13414 485918006640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918006641 binding surface 485918006642 TPR motif; other site 485918006643 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 485918006644 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 485918006645 Moco binding site; other site 485918006646 metal coordination site [ion binding]; other site 485918006647 DNA helicase, putative; Region: TIGR00376 485918006648 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 485918006649 ATP binding site [chemical binding]; other site 485918006650 AAA domain; Region: AAA_12; pfam13087 485918006651 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 485918006652 active site 485918006653 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 485918006654 Zn2+ binding site [ion binding]; other site 485918006655 Mg2+ binding site [ion binding]; other site 485918006656 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 485918006657 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 485918006658 active site 485918006659 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 485918006660 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 485918006661 inhibitor-cofactor binding pocket; inhibition site 485918006662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918006663 catalytic residue [active] 485918006664 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 485918006665 active site 485918006666 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918006667 putative RNA ligase; Region: PHA02142 485918006668 RNA ligase; Region: RNA_ligase; pfam09414 485918006669 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 485918006670 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 485918006671 DNA-binding site [nucleotide binding]; DNA binding site 485918006672 UTRA domain; Region: UTRA; pfam07702 485918006673 N-terminal catalytic domain of mainly uncharacterized eukaryotic proteins similar to alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like_1; cd10791 485918006674 putative active site [active] 485918006675 catalytic site [active] 485918006676 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 485918006677 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 485918006678 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 485918006679 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 485918006680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918006681 putative substrate translocation pore; other site 485918006682 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 485918006683 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 485918006684 RibD C-terminal domain; Region: RibD_C; cl17279 485918006685 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 485918006686 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 485918006687 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 485918006688 conserved cys residue [active] 485918006689 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918006690 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918006691 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918006692 pyruvate dehydrogenase; Provisional; Region: PRK09124 485918006693 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 485918006694 PYR/PP interface [polypeptide binding]; other site 485918006695 dimer interface [polypeptide binding]; other site 485918006696 tetramer interface [polypeptide binding]; other site 485918006697 TPP binding site [chemical binding]; other site 485918006698 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 485918006699 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 485918006700 TPP-binding site [chemical binding]; other site 485918006701 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918006702 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918006703 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 485918006704 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918006705 NAD(P) binding site [chemical binding]; other site 485918006706 active site 485918006707 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 485918006708 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 485918006709 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 485918006710 putative DNA binding site [nucleotide binding]; other site 485918006711 dimerization interface [polypeptide binding]; other site 485918006712 Predicted acetyltransferase [General function prediction only]; Region: COG3393 485918006713 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918006714 Coenzyme A binding pocket [chemical binding]; other site 485918006715 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918006716 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918006717 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918006718 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918006719 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918006720 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918006721 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918006722 FecR protein; Region: FecR; pfam04773 485918006723 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 485918006724 active site 485918006725 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 485918006726 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918006727 DNA binding residues [nucleotide binding] 485918006728 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 485918006729 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918006730 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918006731 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918006732 DNA binding residues [nucleotide binding] 485918006733 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918006734 FecR protein; Region: FecR; pfam04773 485918006735 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918006736 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918006737 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918006738 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918006739 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918006740 SusD family; Region: SusD; pfam07980 485918006741 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 485918006742 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 485918006743 Beta/Gamma crystallin; Region: Crystall; cl02528 485918006744 Beta/Gamma crystallin; Region: Crystall; cl02528 485918006745 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 485918006746 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 485918006747 putative sugar binding sites [chemical binding]; other site 485918006748 Q-X-W motif; other site 485918006749 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 485918006750 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 485918006751 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918006752 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 485918006753 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 485918006754 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 485918006755 Transcriptional regulator [Transcription]; Region: LysR; COG0583 485918006756 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 485918006757 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 485918006758 dimerization interface [polypeptide binding]; other site 485918006759 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 485918006760 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 485918006761 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 485918006762 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918006763 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918006764 catalytic residues [active] 485918006765 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 485918006766 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918006767 GLPGLI family protein; Region: GLPGLI; TIGR01200 485918006768 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 485918006769 Catalytic site [active] 485918006770 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 485918006771 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 485918006772 O-Antigen ligase; Region: Wzy_C; pfam04932 485918006773 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918006774 binding surface 485918006775 TPR repeat; Region: TPR_11; pfam13414 485918006776 TPR motif; other site 485918006777 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 485918006778 putative sugar binding sites [chemical binding]; other site 485918006779 Q-X-W motif; other site 485918006780 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 485918006781 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 485918006782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918006783 short chain dehydrogenase; Provisional; Region: PRK07024 485918006784 NAD(P) binding site [chemical binding]; other site 485918006785 active site 485918006786 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918006787 FtsX-like permease family; Region: FtsX; pfam02687 485918006788 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918006789 FtsX-like permease family; Region: FtsX; pfam02687 485918006790 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 485918006791 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 485918006792 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 485918006793 Cytochrome c; Region: Cytochrom_C; cl11414 485918006794 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 485918006795 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 485918006796 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 485918006797 DinB superfamily; Region: DinB_2; pfam12867 485918006798 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 485918006799 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 485918006800 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 485918006801 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 485918006802 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 485918006803 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918006804 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 485918006805 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 485918006806 N-terminal plug; other site 485918006807 ligand-binding site [chemical binding]; other site 485918006808 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 485918006809 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 485918006810 active site 485918006811 catalytic tetrad [active] 485918006812 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 485918006813 DinB superfamily; Region: DinB_2; pfam12867 485918006814 DinB family; Region: DinB; cl17821 485918006815 DinB superfamily; Region: DinB_2; pfam12867 485918006816 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 485918006817 substrate binding site [chemical binding]; other site 485918006818 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918006819 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918006820 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918006821 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 485918006822 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 485918006823 Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991 485918006824 active site 485918006825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918006826 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 485918006827 putative substrate translocation pore; other site 485918006828 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 485918006829 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 485918006830 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918006831 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918006832 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918006833 ligand binding site [chemical binding]; other site 485918006834 flexible hinge region; other site 485918006835 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 485918006836 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 485918006837 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 485918006838 active site 485918006839 catalytic triad [active] 485918006840 dimer interface [polypeptide binding]; other site 485918006841 Right handed beta helix region; Region: Beta_helix; pfam13229 485918006842 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 485918006843 Protein of unknown function (DUF692); Region: DUF692; cl01263 485918006844 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 485918006845 DNA methylase; Region: N6_N4_Mtase; pfam01555 485918006846 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918006847 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 485918006848 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 485918006849 N-terminal plug; other site 485918006850 ligand-binding site [chemical binding]; other site 485918006851 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 485918006852 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 485918006853 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918006854 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 485918006855 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 485918006856 PYR/PP interface [polypeptide binding]; other site 485918006857 dimer interface [polypeptide binding]; other site 485918006858 TPP binding site [chemical binding]; other site 485918006859 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 485918006860 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 485918006861 TPP-binding site [chemical binding]; other site 485918006862 dimer interface [polypeptide binding]; other site 485918006863 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 485918006864 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 485918006865 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918006866 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 485918006867 binding surface 485918006868 TPR motif; other site 485918006869 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 485918006870 Cupin domain; Region: Cupin_2; pfam07883 485918006871 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918006872 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918006873 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918006874 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 485918006875 NADH(P)-binding; Region: NAD_binding_10; pfam13460 485918006876 NAD binding site [chemical binding]; other site 485918006877 substrate binding site [chemical binding]; other site 485918006878 putative active site [active] 485918006879 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918006880 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918006881 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 485918006882 nudix motif; other site 485918006883 hypothetical protein; Provisional; Region: PRK08317 485918006884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918006885 S-adenosylmethionine binding site [chemical binding]; other site 485918006886 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 485918006887 NlpC/P60 family; Region: NLPC_P60; cl17555 485918006888 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 485918006889 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 485918006890 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 485918006891 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 485918006892 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918006893 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918006894 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918006895 EthD domain; Region: EthD; pfam07110 485918006896 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918006897 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918006898 Peptidase M60-like family; Region: M60-like; pfam13402 485918006899 Haemolytic domain; Region: Haemolytic; cl00506 485918006900 Catalytic domain of Protein Kinases; Region: PKc; cd00180 485918006901 active site 485918006902 ATP binding site [chemical binding]; other site 485918006903 substrate binding site [chemical binding]; other site 485918006904 activation loop (A-loop); other site 485918006905 Peptidase family M48; Region: Peptidase_M48; cl12018 485918006906 Immunity protein Imm1; Region: Imm1; pfam14430 485918006907 putative transposase OrfB; Reviewed; Region: PHA02517 485918006908 HTH-like domain; Region: HTH_21; pfam13276 485918006909 Integrase core domain; Region: rve; pfam00665 485918006910 Integrase core domain; Region: rve_3; pfam13683 485918006911 Transposase; Region: HTH_Tnp_1; pfam01527 485918006912 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 485918006913 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 485918006914 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 485918006915 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 485918006916 Walker A/P-loop; other site 485918006917 ATP binding site [chemical binding]; other site 485918006918 Q-loop/lid; other site 485918006919 ABC transporter signature motif; other site 485918006920 Walker B; other site 485918006921 D-loop; other site 485918006922 H-loop/switch region; other site 485918006923 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 485918006924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 485918006925 Transposase; Region: HTH_Tnp_1; cl17663 485918006926 putative transposase OrfB; Reviewed; Region: PHA02517 485918006927 HTH-like domain; Region: HTH_21; pfam13276 485918006928 Integrase core domain; Region: rve; pfam00665 485918006929 Integrase core domain; Region: rve_3; pfam13683 485918006930 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 485918006931 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 485918006932 non-specific DNA binding site [nucleotide binding]; other site 485918006933 salt bridge; other site 485918006934 sequence-specific DNA binding site [nucleotide binding]; other site 485918006935 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 485918006936 additional DNA contacts [nucleotide binding]; other site 485918006937 mismatch recognition site; other site 485918006938 active site 485918006939 zinc binding site [ion binding]; other site 485918006940 DNA intercalation site [nucleotide binding]; other site 485918006941 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 485918006942 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 485918006943 cofactor binding site; other site 485918006944 DNA binding site [nucleotide binding] 485918006945 substrate interaction site [chemical binding]; other site 485918006946 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 485918006947 Thymidine phosphorylase [Nucleotide transport and metabolism]; Region: DeoA; COG0213 485918006948 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 485918006949 active site 485918006950 ATP binding site [chemical binding]; other site 485918006951 substrate binding site [chemical binding]; other site 485918006952 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 485918006953 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918006954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918006955 ATP binding site [chemical binding]; other site 485918006956 Mg2+ binding site [ion binding]; other site 485918006957 G-X-G motif; other site 485918006958 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918006959 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 485918006960 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 485918006961 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 485918006962 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 485918006963 catalytic residues [active] 485918006964 catalytic nucleophile [active] 485918006965 Recombinase; Region: Recombinase; pfam07508 485918006966 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 485918006967 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 485918006968 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 485918006969 active site 485918006970 catalytic site [active] 485918006971 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 485918006972 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 485918006973 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 485918006974 catalytic site [active] 485918006975 active site 485918006976 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 485918006977 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 485918006978 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 485918006979 Ca binding site [ion binding]; other site 485918006980 active site 485918006981 catalytic site [active] 485918006982 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 485918006983 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 485918006984 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 485918006985 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 485918006986 active site 485918006987 catalytic site [active] 485918006988 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 485918006989 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 485918006990 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 485918006991 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 485918006992 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 485918006993 S1 domain; Region: S1_2; pfam13509 485918006994 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 485918006995 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 485918006996 PKC phosphorylation site [posttranslational modification]; other site 485918006997 Glyco_18 domain; Region: Glyco_18; smart00636 485918006998 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 485918006999 active site 485918007000 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257 485918007001 PKC phosphorylation site [posttranslational modification]; other site 485918007002 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918007003 Beta/Gamma crystallin; Region: Crystall; cl02528 485918007004 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918007005 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918007006 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 485918007007 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918007008 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 485918007009 Outer membrane efflux protein; Region: OEP; pfam02321 485918007010 Outer membrane efflux protein; Region: OEP; pfam02321 485918007011 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918007012 HAMP domain; Region: HAMP; pfam00672 485918007013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918007014 dimer interface [polypeptide binding]; other site 485918007015 phosphorylation site [posttranslational modification] 485918007016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918007017 ATP binding site [chemical binding]; other site 485918007018 Mg2+ binding site [ion binding]; other site 485918007019 G-X-G motif; other site 485918007020 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 485918007021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918007022 active site 485918007023 phosphorylation site [posttranslational modification] 485918007024 intermolecular recognition site; other site 485918007025 dimerization interface [polypeptide binding]; other site 485918007026 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 485918007027 DNA binding site [nucleotide binding] 485918007028 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918007029 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 485918007030 FOG: PKD repeat [General function prediction only]; Region: COG3291 485918007031 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 485918007032 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918007033 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918007034 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 485918007035 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181 485918007036 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 485918007037 Fatty acid desaturase; Region: FA_desaturase; pfam00487 485918007038 putative di-iron ligands [ion binding]; other site 485918007039 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 485918007040 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 485918007041 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 485918007042 putative acyl-acceptor binding pocket; other site 485918007043 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 485918007044 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 485918007045 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918007046 DsrE/DsrF-like family; Region: DrsE; cl00672 485918007047 Cytochrome c [Energy production and conversion]; Region: COG3258 485918007048 Cytochrome c; Region: Cytochrom_C; pfam00034 485918007049 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 485918007050 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 485918007051 active site 485918007052 catalytic site [active] 485918007053 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 485918007054 Sulfatase; Region: Sulfatase; pfam00884 485918007055 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 485918007056 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 485918007057 ATP binding site [chemical binding]; other site 485918007058 Mg++ binding site [ion binding]; other site 485918007059 motif III; other site 485918007060 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 485918007061 nucleotide binding region [chemical binding]; other site 485918007062 ATP-binding site [chemical binding]; other site 485918007063 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 485918007064 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 485918007065 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 485918007066 Tetratricopeptide repeat; Region: TPR_2; pfam07719 485918007067 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 485918007068 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 485918007069 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 485918007070 active site residue [active] 485918007071 Sulphur transport; Region: Sulf_transp; pfam04143 485918007072 Sulphur transport; Region: Sulf_transp; pfam04143 485918007073 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918007074 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918007075 ligand binding site [chemical binding]; other site 485918007076 flexible hinge region; other site 485918007077 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 485918007078 non-specific DNA interactions [nucleotide binding]; other site 485918007079 DNA binding site [nucleotide binding] 485918007080 sequence specific DNA binding site [nucleotide binding]; other site 485918007081 putative cAMP binding site [chemical binding]; other site 485918007082 Phospholipid methyltransferase; Region: PEMT; cl17370 485918007083 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 485918007084 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 485918007085 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 485918007086 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 485918007087 Right handed beta helix region; Region: Beta_helix; pfam13229 485918007088 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 485918007089 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 485918007090 active site 485918007091 substrate binding site [chemical binding]; other site 485918007092 Mg2+ binding site [ion binding]; other site 485918007093 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 485918007094 Beta-lactamase; Region: Beta-lactamase; pfam00144 485918007095 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918007096 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 485918007097 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 485918007098 active site 485918007099 metal binding site [ion binding]; metal-binding site 485918007100 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 485918007101 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 485918007102 active site 485918007103 catalytic tetrad [active] 485918007104 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918007105 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918007106 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 485918007107 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918007108 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918007109 DNA binding residues [nucleotide binding] 485918007110 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 485918007111 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 485918007112 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918007113 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918007114 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 485918007115 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 485918007116 putative NAD(P) binding site [chemical binding]; other site 485918007117 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918007118 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918007119 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918007120 MFS transport protein AraJ; Provisional; Region: PRK10091 485918007121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918007122 putative substrate translocation pore; other site 485918007123 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 485918007124 DNA-binding site [nucleotide binding]; DNA binding site 485918007125 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 485918007126 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 485918007127 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918007128 homodimer interface [polypeptide binding]; other site 485918007129 catalytic residue [active] 485918007130 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 485918007131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 485918007132 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 485918007133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918007134 Coenzyme A binding pocket [chemical binding]; other site 485918007135 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 485918007136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918007137 Major Facilitator Superfamily; Region: MFS_1; pfam07690 485918007138 putative substrate translocation pore; other site 485918007139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918007140 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918007141 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918007142 Domain of Unknown Function with PDB structure (DUF3863); Region: DUF3863; pfam12979 485918007143 Domain of Unknown Function with PDB structure (DUF3864); Region: DUF3864; pfam12980 485918007144 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918007145 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918007146 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 485918007147 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 485918007148 putative NAD(P) binding site [chemical binding]; other site 485918007149 CheB methylesterase; Region: CheB_methylest; pfam01339 485918007150 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 485918007151 nucleoside/Zn binding site; other site 485918007152 dimer interface [polypeptide binding]; other site 485918007153 catalytic motif [active] 485918007154 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 485918007155 MarR family; Region: MarR; pfam01047 485918007156 MarR family; Region: MarR_2; cl17246 485918007157 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918007158 Coenzyme A binding pocket [chemical binding]; other site 485918007159 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 485918007160 short chain dehydrogenase; Validated; Region: PRK06182 485918007161 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918007162 NADP binding site [chemical binding]; other site 485918007163 active site 485918007164 steroid binding site; other site 485918007165 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918007166 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918007167 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918007168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918007169 active site 485918007170 phosphorylation site [posttranslational modification] 485918007171 intermolecular recognition site; other site 485918007172 dimerization interface [polypeptide binding]; other site 485918007173 LytTr DNA-binding domain; Region: LytTR; smart00850 485918007174 Histidine kinase; Region: His_kinase; pfam06580 485918007175 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 485918007176 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918007177 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918007178 catalytic residues [active] 485918007179 Histidine kinase; Region: His_kinase; pfam06580 485918007180 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918007181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918007182 active site 485918007183 phosphorylation site [posttranslational modification] 485918007184 intermolecular recognition site; other site 485918007185 dimerization interface [polypeptide binding]; other site 485918007186 LytTr DNA-binding domain; Region: LytTR; smart00850 485918007187 Outer membrane efflux protein; Region: OEP; pfam02321 485918007188 Outer membrane efflux protein; Region: OEP; pfam02321 485918007189 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918007190 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918007191 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 485918007192 Protein export membrane protein; Region: SecD_SecF; cl14618 485918007193 MutS domain III; Region: MutS_III; pfam05192 485918007194 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918007195 Walker A/P-loop; other site 485918007196 ATP binding site [chemical binding]; other site 485918007197 Q-loop/lid; other site 485918007198 ABC transporter signature motif; other site 485918007199 Walker B; other site 485918007200 D-loop; other site 485918007201 H-loop/switch region; other site 485918007202 MutS domain III; Region: MutS_III; pfam05192 485918007203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918007204 Walker A/P-loop; other site 485918007205 ATP binding site [chemical binding]; other site 485918007206 Q-loop/lid; other site 485918007207 ABC transporter signature motif; other site 485918007208 Walker B; other site 485918007209 D-loop; other site 485918007210 H-loop/switch region; other site 485918007211 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 485918007212 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 485918007213 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 485918007214 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 485918007215 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 485918007216 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918007217 Walker A/P-loop; other site 485918007218 ATP binding site [chemical binding]; other site 485918007219 Q-loop/lid; other site 485918007220 ABC transporter signature motif; other site 485918007221 Walker B; other site 485918007222 D-loop; other site 485918007223 H-loop/switch region; other site 485918007224 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918007225 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918007226 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918007227 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918007228 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918007229 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 485918007230 FecR protein; Region: FecR; pfam04773 485918007231 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918007232 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 485918007233 DNA binding residues [nucleotide binding] 485918007234 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 485918007235 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 485918007236 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 485918007237 putative active site [active] 485918007238 putative metal binding site [ion binding]; other site 485918007239 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918007240 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918007241 ligand binding site [chemical binding]; other site 485918007242 flexible hinge region; other site 485918007243 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 485918007244 dimer interface [polypeptide binding]; other site 485918007245 FMN binding site [chemical binding]; other site 485918007246 Rhomboid family; Region: Rhomboid; cl11446 485918007247 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 485918007248 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918007249 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918007250 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 485918007251 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 485918007252 putative active site [active] 485918007253 heme pocket [chemical binding]; other site 485918007254 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918007255 putative active site [active] 485918007256 heme pocket [chemical binding]; other site 485918007257 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918007258 dimer interface [polypeptide binding]; other site 485918007259 phosphorylation site [posttranslational modification] 485918007260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918007261 ATP binding site [chemical binding]; other site 485918007262 Mg2+ binding site [ion binding]; other site 485918007263 G-X-G motif; other site 485918007264 Uncharacterized conserved protein [Function unknown]; Region: COG2353 485918007265 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918007266 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918007267 ligand binding site [chemical binding]; other site 485918007268 flexible hinge region; other site 485918007269 GAF domain; Region: GAF_3; pfam13492 485918007270 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918007271 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918007272 dimer interface [polypeptide binding]; other site 485918007273 phosphorylation site [posttranslational modification] 485918007274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918007275 ATP binding site [chemical binding]; other site 485918007276 Mg2+ binding site [ion binding]; other site 485918007277 G-X-G motif; other site 485918007278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918007279 active site 485918007280 phosphorylation site [posttranslational modification] 485918007281 intermolecular recognition site; other site 485918007282 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918007283 dimerization interface [polypeptide binding]; other site 485918007284 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918007285 dimer interface [polypeptide binding]; other site 485918007286 phosphorylation site [posttranslational modification] 485918007287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918007288 ATP binding site [chemical binding]; other site 485918007289 Mg2+ binding site [ion binding]; other site 485918007290 G-X-G motif; other site 485918007291 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 485918007292 Outer membrane efflux protein; Region: OEP; pfam02321 485918007293 Second Mitochondria-derived Activator of Caspases; Region: Smac_DIABLO; pfam09057 485918007294 Outer membrane efflux protein; Region: OEP; pfam02321 485918007295 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 485918007296 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918007297 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 485918007298 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 485918007299 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 485918007300 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 485918007301 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918007302 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918007303 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 485918007304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918007305 NAD(P) binding site [chemical binding]; other site 485918007306 active site 485918007307 short chain dehydrogenase; Provisional; Region: PRK06180 485918007308 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918007309 NADP binding site [chemical binding]; other site 485918007310 active site 485918007311 steroid binding site; other site 485918007312 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 485918007313 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 485918007314 conserved cys residue [active] 485918007315 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918007316 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918007317 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918007318 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918007319 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918007320 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918007321 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 485918007322 zinc binding site [ion binding]; other site 485918007323 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 485918007324 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 485918007325 Zn2+ binding site [ion binding]; other site 485918007326 Mg2+ binding site [ion binding]; other site 485918007327 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 485918007328 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918007329 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918007330 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 485918007331 PQQ-like domain; Region: PQQ_2; pfam13360 485918007332 Trp docking motif [polypeptide binding]; other site 485918007333 putative active site [active] 485918007334 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 485918007335 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 485918007336 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918007337 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 485918007338 Histidine kinase; Region: HisKA_2; pfam07568 485918007339 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 485918007340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918007341 ATP binding site [chemical binding]; other site 485918007342 Mg2+ binding site [ion binding]; other site 485918007343 G-X-G motif; other site 485918007344 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918007345 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918007346 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 485918007347 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 485918007348 DsrE/DsrF-like family; Region: DrsE; pfam02635 485918007349 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 485918007350 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 485918007351 active site 485918007352 FMN binding site [chemical binding]; other site 485918007353 substrate binding site [chemical binding]; other site 485918007354 putative catalytic residue [active] 485918007355 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 485918007356 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 485918007357 catalytic residues [active] 485918007358 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 485918007359 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918007360 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918007361 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918007362 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 485918007363 Beta-lactamase; Region: Beta-lactamase; pfam00144 485918007364 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918007365 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918007366 ligand binding site [chemical binding]; other site 485918007367 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 485918007368 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 485918007369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 485918007370 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 485918007371 active site 1 [active] 485918007372 dimer interface [polypeptide binding]; other site 485918007373 hexamer interface [polypeptide binding]; other site 485918007374 active site 2 [active] 485918007375 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 485918007376 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 485918007377 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 485918007378 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 485918007379 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 485918007380 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918007381 SusD family; Region: SusD; pfam07980 485918007382 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918007383 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918007384 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918007385 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918007386 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 485918007387 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 485918007388 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918007389 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918007390 dimer interface [polypeptide binding]; other site 485918007391 phosphorylation site [posttranslational modification] 485918007392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918007393 ATP binding site [chemical binding]; other site 485918007394 Mg2+ binding site [ion binding]; other site 485918007395 G-X-G motif; other site 485918007396 Response regulator receiver domain; Region: Response_reg; pfam00072 485918007397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918007398 active site 485918007399 phosphorylation site [posttranslational modification] 485918007400 intermolecular recognition site; other site 485918007401 dimerization interface [polypeptide binding]; other site 485918007402 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918007403 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918007404 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 485918007405 putative sugar binding sites [chemical binding]; other site 485918007406 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 485918007407 Q-X-W motif; other site 485918007408 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 485918007409 ligand binding site [chemical binding]; other site 485918007410 active site 485918007411 UGI interface [polypeptide binding]; other site 485918007412 catalytic site [active] 485918007413 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918007414 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918007415 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 485918007416 Outer membrane efflux protein; Region: OEP; pfam02321 485918007417 Outer membrane efflux protein; Region: OEP; pfam02321 485918007418 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 485918007419 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 485918007420 Methyltransferase domain; Region: Methyltransf_23; pfam13489 485918007421 Methyltransferase domain; Region: Methyltransf_12; pfam08242 485918007422 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 485918007423 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 485918007424 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 485918007425 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 485918007426 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 485918007427 Right handed beta helix region; Region: Beta_helix; pfam13229 485918007428 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 485918007429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 485918007430 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 485918007431 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918007432 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918007433 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918007434 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918007435 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918007436 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918007437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918007438 dimer interface [polypeptide binding]; other site 485918007439 phosphorylation site [posttranslational modification] 485918007440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918007441 ATP binding site [chemical binding]; other site 485918007442 Mg2+ binding site [ion binding]; other site 485918007443 G-X-G motif; other site 485918007444 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 485918007445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918007446 active site 485918007447 phosphorylation site [posttranslational modification] 485918007448 intermolecular recognition site; other site 485918007449 dimerization interface [polypeptide binding]; other site 485918007450 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 485918007451 DNA binding site [nucleotide binding] 485918007452 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 485918007453 Sulfatase; Region: Sulfatase; pfam00884 485918007454 Sulfatase; Region: Sulfatase; cl17466 485918007455 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918007456 FtsX-like permease family; Region: FtsX; pfam02687 485918007457 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918007458 FtsX-like permease family; Region: FtsX; pfam02687 485918007459 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918007460 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918007461 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918007462 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918007463 amino acid transporter; Region: 2A0306; TIGR00909 485918007464 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 485918007465 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 485918007466 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 485918007467 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 485918007468 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 485918007469 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 485918007470 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 485918007471 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 485918007472 protein binding site [polypeptide binding]; other site 485918007473 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 485918007474 Domain interface; other site 485918007475 Peptide binding site; other site 485918007476 Active site tetrad [active] 485918007477 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 485918007478 Penicillinase repressor; Region: Pencillinase_R; cl17580 485918007479 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 485918007480 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 485918007481 DNA-binding site [nucleotide binding]; DNA binding site 485918007482 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 485918007483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918007484 homodimer interface [polypeptide binding]; other site 485918007485 catalytic residue [active] 485918007486 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 485918007487 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 485918007488 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918007489 Coenzyme A binding pocket [chemical binding]; other site 485918007490 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 485918007491 DJ-1 family protein; Region: not_thiJ; TIGR01383 485918007492 conserved cys residue [active] 485918007493 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 485918007494 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 485918007495 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918007496 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 485918007497 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 485918007498 conserved cys residue [active] 485918007499 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918007500 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918007501 ethanolamine permease; Region: 2A0305; TIGR00908 485918007502 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 485918007503 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 485918007504 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 485918007505 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918007506 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918007507 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918007508 DNA binding residues [nucleotide binding] 485918007509 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918007510 FecR protein; Region: FecR; pfam04773 485918007511 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918007512 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918007513 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918007514 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918007515 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918007516 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 485918007517 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918007518 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 485918007519 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 485918007520 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 485918007521 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 485918007522 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 485918007523 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918007524 TANFOR domain; Region: T_forsyth_147; TIGR02542 485918007525 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 485918007526 Interdomain contacts; other site 485918007527 Cytokine receptor motif; other site 485918007528 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 485918007529 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 485918007530 methionine sulfoxide reductase A; Provisional; Region: PRK14054 485918007531 MutS domain III; Region: MutS_III; pfam05192 485918007532 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 485918007533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918007534 Walker A/P-loop; other site 485918007535 ATP binding site [chemical binding]; other site 485918007536 Q-loop/lid; other site 485918007537 ABC transporter signature motif; other site 485918007538 Walker B; other site 485918007539 D-loop; other site 485918007540 H-loop/switch region; other site 485918007541 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 485918007542 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 485918007543 putative DNA binding site [nucleotide binding]; other site 485918007544 putative Zn2+ binding site [ion binding]; other site 485918007545 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918007546 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918007547 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918007548 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918007549 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 485918007550 E3 interaction surface; other site 485918007551 lipoyl attachment site [posttranslational modification]; other site 485918007552 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918007553 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 485918007554 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 485918007555 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 485918007556 Coenzyme A binding pocket [chemical binding]; other site 485918007557 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 485918007558 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 485918007559 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918007560 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 485918007561 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 485918007562 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918007563 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918007564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918007565 Uncharacterized conserved protein [Function unknown]; Region: COG2128 485918007566 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 485918007567 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918007568 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918007569 Beta-lactamase; Region: Beta-lactamase; pfam00144 485918007570 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 485918007571 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 485918007572 substrate binding site [chemical binding]; other site 485918007573 Caspase domain; Region: Peptidase_C14; pfam00656 485918007574 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 485918007575 active site 485918007576 catalytic triad [active] 485918007577 oxyanion hole [active] 485918007578 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 485918007579 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 485918007580 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 485918007581 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918007582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 485918007583 ACT domain; Region: ACT_3; pfam10000 485918007584 Family description; Region: ACT_7; pfam13840 485918007585 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 485918007586 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 485918007587 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 485918007588 active site 485918007589 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 485918007590 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 485918007591 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 485918007592 active site 485918007593 nucleophile elbow; other site 485918007594 Peptidase of plants and bacteria; Region: BSP; pfam04450 485918007595 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 485918007596 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 485918007597 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 485918007598 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 485918007599 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 485918007600 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 485918007601 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 485918007602 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 485918007603 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 485918007604 protein binding site [polypeptide binding]; other site 485918007605 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 485918007606 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 485918007607 conserved cys residue [active] 485918007608 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918007609 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918007610 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918007611 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 485918007612 nucleophilic elbow; other site 485918007613 catalytic triad; other site 485918007614 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918007615 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918007616 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 485918007617 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 485918007618 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 485918007619 G1 box; other site 485918007620 GTP/Mg2+ binding site [chemical binding]; other site 485918007621 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 485918007622 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 485918007623 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918007624 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918007625 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918007626 DNA binding residues [nucleotide binding] 485918007627 FecR protein; Region: FecR; pfam04773 485918007628 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918007629 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918007630 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918007631 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918007632 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918007633 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918007634 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918007635 SusD family; Region: SusD; pfam07980 485918007636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918007637 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 485918007638 Walker A motif; other site 485918007639 ATP binding site [chemical binding]; other site 485918007640 Walker B motif; other site 485918007641 arginine finger; other site 485918007642 CAAX protease self-immunity; Region: Abi; pfam02517 485918007643 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 485918007644 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 485918007645 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 485918007646 putative DNA binding site [nucleotide binding]; other site 485918007647 putative Zn2+ binding site [ion binding]; other site 485918007648 AsnC family; Region: AsnC_trans_reg; pfam01037 485918007649 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 485918007650 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 485918007651 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918007652 Outer membrane efflux protein; Region: OEP; pfam02321 485918007653 Outer membrane efflux protein; Region: OEP; pfam02321 485918007654 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918007655 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918007656 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 485918007657 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 485918007658 active site 485918007659 catalytic tetrad [active] 485918007660 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 485918007661 active site 485918007662 iron coordination sites [ion binding]; other site 485918007663 substrate binding pocket [chemical binding]; other site 485918007664 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 485918007665 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 485918007666 catalytic residue [active] 485918007667 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 485918007668 IucA / IucC family; Region: IucA_IucC; pfam04183 485918007669 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 485918007670 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 485918007671 IucA / IucC family; Region: IucA_IucC; pfam04183 485918007672 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 485918007673 Creatinine amidohydrolase; Region: Creatininase; pfam02633 485918007674 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 485918007675 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 485918007676 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 485918007677 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 485918007678 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 485918007679 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_14; cd13139 485918007680 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 485918007681 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 485918007682 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 485918007683 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 485918007684 acyl-activating enzyme (AAE) consensus motif; other site 485918007685 AMP binding site [chemical binding]; other site 485918007686 active site 485918007687 CoA binding site [chemical binding]; other site 485918007688 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918007689 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 485918007690 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 485918007691 N-terminal plug; other site 485918007692 ligand-binding site [chemical binding]; other site 485918007693 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918007694 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918007695 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918007696 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918007697 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918007698 Glycosyl hydrolase family 43; Region: GH43_7; cd08986 485918007699 active site 485918007700 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 485918007701 Sulfatase; Region: Sulfatase; pfam00884 485918007702 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 485918007703 Sulfatase; Region: Sulfatase; pfam00884 485918007704 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 485918007705 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 485918007706 Two component regulator propeller; Region: Reg_prop; pfam07494 485918007707 Two component regulator propeller; Region: Reg_prop; pfam07494 485918007708 Two component regulator propeller; Region: Reg_prop; pfam07494 485918007709 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 485918007710 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918007711 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918007712 dimer interface [polypeptide binding]; other site 485918007713 phosphorylation site [posttranslational modification] 485918007714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918007715 ATP binding site [chemical binding]; other site 485918007716 Mg2+ binding site [ion binding]; other site 485918007717 G-X-G motif; other site 485918007718 Response regulator receiver domain; Region: Response_reg; pfam00072 485918007719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918007720 active site 485918007721 phosphorylation site [posttranslational modification] 485918007722 intermolecular recognition site; other site 485918007723 dimerization interface [polypeptide binding]; other site 485918007724 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918007725 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918007726 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918007727 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 485918007728 FtsX-like permease family; Region: FtsX; pfam02687 485918007729 FtsX-like permease family; Region: FtsX; pfam02687 485918007730 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 485918007731 active site 485918007732 catalytic triad [active] 485918007733 oxyanion hole [active] 485918007734 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918007735 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918007736 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918007737 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918007738 DNA binding residues [nucleotide binding] 485918007739 FecR protein; Region: FecR; pfam04773 485918007740 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918007741 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918007742 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918007743 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918007744 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918007745 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918007746 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918007747 SusD family; Region: SusD; pfam07980 485918007748 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 485918007749 Interdomain contacts; other site 485918007750 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 485918007751 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 485918007752 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 485918007753 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 485918007754 sugar binding site [chemical binding]; other site 485918007755 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 485918007756 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 485918007757 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 485918007758 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 485918007759 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 485918007760 putative substrate binding site [chemical binding]; other site 485918007761 active site 485918007762 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 485918007763 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 485918007764 putative sugar binding sites [chemical binding]; other site 485918007765 Q-X-W motif; other site 485918007766 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 485918007767 Flagellin N-methylase; Region: FliB; pfam03692 485918007768 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918007769 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 485918007770 nucleophilic elbow; other site 485918007771 catalytic triad; other site 485918007772 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 485918007773 DNA binding residues [nucleotide binding] 485918007774 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 485918007775 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918007776 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918007777 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918007778 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918007779 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 485918007780 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 485918007781 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 485918007782 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918007783 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918007784 catalytic residues [active] 485918007785 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 485918007786 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918007787 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918007788 catalytic residues [active] 485918007789 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 485918007790 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 485918007791 sugar binding site [chemical binding]; other site 485918007792 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918007793 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918007794 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918007795 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918007796 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918007797 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918007798 FecR protein; Region: FecR; pfam04773 485918007799 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918007800 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918007801 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918007802 DNA binding residues [nucleotide binding] 485918007803 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 485918007804 nudix motif; other site 485918007805 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 485918007806 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 485918007807 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918007808 NAD(P) binding site [chemical binding]; other site 485918007809 active site 485918007810 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 485918007811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918007812 NAD(P) binding site [chemical binding]; other site 485918007813 active site 485918007814 Sugar fermentation stimulation protein; Region: SfsA; cl00647 485918007815 Response regulator receiver domain; Region: Response_reg; pfam00072 485918007816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918007817 active site 485918007818 phosphorylation site [posttranslational modification] 485918007819 intermolecular recognition site; other site 485918007820 dimerization interface [polypeptide binding]; other site 485918007821 short chain dehydrogenase; Provisional; Region: PRK06500 485918007822 classical (c) SDRs; Region: SDR_c; cd05233 485918007823 NAD(P) binding site [chemical binding]; other site 485918007824 active site 485918007825 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918007826 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918007827 ligand binding site [chemical binding]; other site 485918007828 flexible hinge region; other site 485918007829 short chain dehydrogenase; Provisional; Region: PRK06500 485918007830 classical (c) SDRs; Region: SDR_c; cd05233 485918007831 NAD(P) binding site [chemical binding]; other site 485918007832 active site 485918007833 short chain dehydrogenase; Provisional; Region: PRK06914 485918007834 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918007835 NADP binding site [chemical binding]; other site 485918007836 active site 485918007837 steroid binding site; other site 485918007838 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918007839 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918007840 ligand binding site [chemical binding]; other site 485918007841 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918007842 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918007843 OsmC-like protein; Region: OsmC; cl00767 485918007844 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 485918007845 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 485918007846 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 485918007847 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918007848 MerC mercury resistance protein; Region: MerC; pfam03203 485918007849 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 485918007850 catalytic core [active] 485918007851 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918007852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918007853 active site 485918007854 phosphorylation site [posttranslational modification] 485918007855 intermolecular recognition site; other site 485918007856 dimerization interface [polypeptide binding]; other site 485918007857 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918007858 DNA binding residues [nucleotide binding] 485918007859 dimerization interface [polypeptide binding]; other site 485918007860 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 485918007861 Histidine kinase; Region: HisKA_3; pfam07730 485918007862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918007863 ATP binding site [chemical binding]; other site 485918007864 Mg2+ binding site [ion binding]; other site 485918007865 G-X-G motif; other site 485918007866 Transcriptional regulators [Transcription]; Region: MarR; COG1846 485918007867 MarR family; Region: MarR_2; pfam12802 485918007868 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 485918007869 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 485918007870 DNA-binding site [nucleotide binding]; DNA binding site 485918007871 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 485918007872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918007873 homodimer interface [polypeptide binding]; other site 485918007874 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 485918007875 dimerization interface [polypeptide binding]; other site 485918007876 putative DNA binding site [nucleotide binding]; other site 485918007877 putative Zn2+ binding site [ion binding]; other site 485918007878 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918007879 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918007880 Outer membrane efflux protein; Region: OEP; pfam02321 485918007881 Outer membrane efflux protein; Region: OEP; pfam02321 485918007882 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 485918007883 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918007884 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 485918007885 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 485918007886 Walker A/P-loop; other site 485918007887 ATP binding site [chemical binding]; other site 485918007888 Q-loop/lid; other site 485918007889 ABC transporter signature motif; other site 485918007890 Walker B; other site 485918007891 D-loop; other site 485918007892 H-loop/switch region; other site 485918007893 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 485918007894 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 485918007895 Walker A/P-loop; other site 485918007896 ATP binding site [chemical binding]; other site 485918007897 Q-loop/lid; other site 485918007898 ABC transporter signature motif; other site 485918007899 Walker B; other site 485918007900 D-loop; other site 485918007901 H-loop/switch region; other site 485918007902 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 485918007903 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 485918007904 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 485918007905 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 485918007906 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 485918007907 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 485918007908 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 485918007909 DNA-binding site [nucleotide binding]; DNA binding site 485918007910 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 485918007911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918007912 homodimer interface [polypeptide binding]; other site 485918007913 catalytic residue [active] 485918007914 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 485918007915 dimerization interface [polypeptide binding]; other site 485918007916 putative DNA binding site [nucleotide binding]; other site 485918007917 putative Zn2+ binding site [ion binding]; other site 485918007918 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 485918007919 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 485918007920 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 485918007921 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 485918007922 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 485918007923 minor groove reading motif; other site 485918007924 helix-hairpin-helix signature motif; other site 485918007925 substrate binding pocket [chemical binding]; other site 485918007926 active site 485918007927 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 485918007928 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 485918007929 DNA binding site [nucleotide binding] 485918007930 active site 485918007931 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 485918007932 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 485918007933 catalytic residue [active] 485918007934 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 485918007935 EamA-like transporter family; Region: EamA; pfam00892 485918007936 EamA-like transporter family; Region: EamA; pfam00892 485918007937 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 485918007938 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918007939 Coenzyme A binding pocket [chemical binding]; other site 485918007940 DinB superfamily; Region: DinB_2; pfam12867 485918007941 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 485918007942 ADP-ribose binding site [chemical binding]; other site 485918007943 dimer interface [polypeptide binding]; other site 485918007944 active site 485918007945 nudix motif; other site 485918007946 metal binding site [ion binding]; metal-binding site 485918007947 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 485918007948 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 485918007949 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 485918007950 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 485918007951 active site 485918007952 catalytic residues [active] 485918007953 metal binding site [ion binding]; metal-binding site 485918007954 GSCFA family; Region: GSCFA; pfam08885 485918007955 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 485918007956 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 485918007957 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 485918007958 active site 485918007959 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918007960 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918007961 short chain dehydrogenase; Provisional; Region: PRK08263 485918007962 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918007963 NADP binding site [chemical binding]; other site 485918007964 active site 485918007965 steroid binding site; other site 485918007966 short chain dehydrogenase; Provisional; Region: PRK06180 485918007967 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918007968 NADP binding site [chemical binding]; other site 485918007969 active site 485918007970 steroid binding site; other site 485918007971 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 485918007972 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 485918007973 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 485918007974 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 485918007975 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918007976 Walker A/P-loop; other site 485918007977 ATP binding site [chemical binding]; other site 485918007978 Q-loop/lid; other site 485918007979 ABC transporter signature motif; other site 485918007980 Walker B; other site 485918007981 D-loop; other site 485918007982 H-loop/switch region; other site 485918007983 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918007984 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918007985 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918007986 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918007987 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918007988 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918007989 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918007990 FecR protein; Region: FecR; pfam04773 485918007991 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918007992 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918007993 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918007994 DNA binding residues [nucleotide binding] 485918007995 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 485918007996 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 485918007997 conserved cys residue [active] 485918007998 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918007999 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 485918008000 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 485918008001 conserved cys residue [active] 485918008002 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 485918008003 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 485918008004 active site 485918008005 substrate binding site [chemical binding]; other site 485918008006 Mg2+ binding site [ion binding]; other site 485918008007 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918008008 FtsX-like permease family; Region: FtsX; pfam02687 485918008009 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918008010 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 485918008011 active site 485918008012 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 485918008013 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 485918008014 hypothetical protein; Provisional; Region: PRK07588 485918008015 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 485918008016 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918008017 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918008018 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918008019 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 485918008020 phosphoenolpyruvate synthase; Validated; Region: PRK06241 485918008021 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 485918008022 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 485918008023 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 485918008024 Mechanosensitive ion channel; Region: MS_channel; pfam00924 485918008025 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918008026 Protein of unknown function (DUF808); Region: DUF808; cl01002 485918008027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918008028 major facilitator superfamily transporter; Provisional; Region: PRK05122 485918008029 putative substrate translocation pore; other site 485918008030 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918008031 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918008032 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918008033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 485918008034 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 485918008035 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 485918008036 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 485918008037 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 485918008038 Uncharacterized conserved protein [Function unknown]; Region: COG3379 485918008039 Fn3 associated; Region: Fn3_assoc; pfam13287 485918008040 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 485918008041 Glycosyl hydrolase families 43 and 62 form CAZY clan GH-F; Region: GH_F; cd08978 485918008042 active site 485918008043 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 485918008044 putative metal binding site [ion binding]; other site 485918008045 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 485918008046 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 485918008047 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918008048 Coenzyme A binding pocket [chemical binding]; other site 485918008049 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 485918008050 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 485918008051 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 485918008052 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 485918008053 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918008054 FtsX-like permease family; Region: FtsX; pfam02687 485918008055 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918008056 FtsX-like permease family; Region: FtsX; pfam02687 485918008057 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 485918008058 TAP-like protein; Region: Abhydrolase_4; pfam08386 485918008059 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918008060 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 485918008061 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 485918008062 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 485918008063 putative di-iron ligands [ion binding]; other site 485918008064 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 485918008065 Predicted ATPase [General function prediction only]; Region: COG4637 485918008066 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 485918008067 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 485918008068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918008069 putative substrate translocation pore; other site 485918008070 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 485918008071 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 485918008072 active site 485918008073 nucleophile elbow; other site 485918008074 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 485918008075 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 485918008076 active site 485918008077 dinuclear metal binding site [ion binding]; other site 485918008078 dimerization interface [polypeptide binding]; other site 485918008079 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 485918008080 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 485918008081 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 485918008082 catalytic residue [active] 485918008083 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 485918008084 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 485918008085 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 485918008086 active site 485918008087 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 485918008088 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 485918008089 catalytic residues [active] 485918008090 catalytic nucleophile [active] 485918008091 Recombinase; Region: Recombinase; pfam07508 485918008092 MutS domain III; Region: MutS_III; cl17822 485918008093 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 485918008094 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918008095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918008096 ATP binding site [chemical binding]; other site 485918008097 Mg2+ binding site [ion binding]; other site 485918008098 G-X-G motif; other site 485918008099 TIGR03545 family protein; Region: TIGR03545 485918008100 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 485918008101 replicative DNA helicase; Provisional; Region: PRK05973 485918008102 Caspase domain; Region: Peptidase_C14; pfam00656 485918008103 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 485918008104 AAA ATPase domain; Region: AAA_15; pfam13175 485918008105 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918008106 Walker A/P-loop; other site 485918008107 ATP binding site [chemical binding]; other site 485918008108 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 485918008109 putative active site [active] 485918008110 putative metal-binding site [ion binding]; other site 485918008111 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 485918008112 HSP70 interaction site [polypeptide binding]; other site 485918008113 Competence protein CoiA-like family; Region: CoiA; cl11541 485918008114 Winged helix-turn helix; Region: HTH_29; pfam13551 485918008115 Helix-turn-helix domain; Region: HTH_28; pfam13518 485918008116 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 485918008117 Integrase core domain; Region: rve; pfam00665 485918008118 Integrase core domain; Region: rve_3; pfam13683 485918008119 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 485918008120 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 485918008121 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918008122 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 485918008123 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918008124 Protein of unknown function (DUF420); Region: DUF420; cl00989 485918008125 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 485918008126 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 485918008127 conserved cys residue [active] 485918008128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918008129 Predicted membrane protein [Function unknown]; Region: COG2259 485918008130 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 485918008131 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918008132 putative catalytic residues [active] 485918008133 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 485918008134 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 485918008135 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 485918008136 active site 485918008137 zinc binding site [ion binding]; other site 485918008138 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 485918008139 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 485918008140 catalytic triad [active] 485918008141 Predicted transcriptional regulator [Transcription]; Region: COG2378 485918008142 HTH domain; Region: HTH_11; pfam08279 485918008143 WYL domain; Region: WYL; pfam13280 485918008144 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 485918008145 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918008146 ABC transporter signature motif; other site 485918008147 Walker B; other site 485918008148 D-loop; other site 485918008149 H-loop/switch region; other site 485918008150 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14262 485918008151 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918008152 Walker A/P-loop; other site 485918008153 ATP binding site [chemical binding]; other site 485918008154 Q-loop/lid; other site 485918008155 ABC transporter signature motif; other site 485918008156 Walker B; other site 485918008157 D-loop; other site 485918008158 H-loop/switch region; other site 485918008159 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918008160 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918008161 short chain dehydrogenase; Provisional; Region: PRK06523 485918008162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918008163 NAD(P) binding site [chemical binding]; other site 485918008164 active site 485918008165 HD domain; Region: HD_3; pfam13023 485918008166 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 485918008167 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918008168 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918008169 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918008170 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 485918008171 DNA binding residues [nucleotide binding] 485918008172 FecR protein; Region: FecR; pfam04773 485918008173 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918008174 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918008175 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918008176 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918008177 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918008178 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918008179 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 485918008180 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918008181 Walker A/P-loop; other site 485918008182 ATP binding site [chemical binding]; other site 485918008183 Q-loop/lid; other site 485918008184 ABC transporter signature motif; other site 485918008185 Walker B; other site 485918008186 D-loop; other site 485918008187 H-loop/switch region; other site 485918008188 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 485918008189 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 485918008190 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 485918008191 MutS domain III; Region: MutS_III; pfam05192 485918008192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918008193 Walker A/P-loop; other site 485918008194 ATP binding site [chemical binding]; other site 485918008195 Q-loop/lid; other site 485918008196 ABC transporter signature motif; other site 485918008197 Walker B; other site 485918008198 D-loop; other site 485918008199 H-loop/switch region; other site 485918008200 MutS domain III; Region: MutS_III; pfam05192 485918008201 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918008202 Walker A/P-loop; other site 485918008203 ATP binding site [chemical binding]; other site 485918008204 Q-loop/lid; other site 485918008205 ABC transporter signature motif; other site 485918008206 Walker B; other site 485918008207 D-loop; other site 485918008208 H-loop/switch region; other site 485918008209 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 485918008210 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 485918008211 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 485918008212 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 485918008213 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 485918008214 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918008215 binding surface 485918008216 TPR repeat; Region: TPR_11; pfam13414 485918008217 TPR motif; other site 485918008218 TPR repeat; Region: TPR_11; pfam13414 485918008219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918008220 binding surface 485918008221 TPR repeat; Region: TPR_11; pfam13414 485918008222 TPR motif; other site 485918008223 TPR repeat; Region: TPR_11; pfam13414 485918008224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918008225 binding surface 485918008226 TPR motif; other site 485918008227 TPR repeat; Region: TPR_11; pfam13414 485918008228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918008229 binding surface 485918008230 TPR motif; other site 485918008231 TPR repeat; Region: TPR_11; pfam13414 485918008232 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918008233 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918008234 ligand binding site [chemical binding]; other site 485918008235 flexible hinge region; other site 485918008236 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 485918008237 active site 485918008238 Pyrococcus aspartate kinase subunit, putative; Region: AspKin_pair; TIGR02078 485918008239 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 485918008240 nucleotide binding site [chemical binding]; other site 485918008241 substrate binding site [chemical binding]; other site 485918008242 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 485918008243 AMP binding site [chemical binding]; other site 485918008244 metal binding site [ion binding]; metal-binding site 485918008245 active site 485918008246 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 485918008247 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 485918008248 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 485918008249 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 485918008250 Walker A/P-loop; other site 485918008251 ATP binding site [chemical binding]; other site 485918008252 Q-loop/lid; other site 485918008253 ABC transporter signature motif; other site 485918008254 Walker B; other site 485918008255 D-loop; other site 485918008256 H-loop/switch region; other site 485918008257 metal-dependent hydrolase; Provisional; Region: PRK13291 485918008258 DinB superfamily; Region: DinB_2; pfam12867 485918008259 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 485918008260 dimer interface [polypeptide binding]; other site 485918008261 ADP-ribose binding site [chemical binding]; other site 485918008262 active site 485918008263 nudix motif; other site 485918008264 metal binding site [ion binding]; metal-binding site 485918008265 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 485918008266 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 485918008267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918008268 Major Facilitator Superfamily; Region: MFS_1; pfam07690 485918008269 putative substrate translocation pore; other site 485918008270 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 485918008271 Radical SAM superfamily; Region: Radical_SAM; pfam04055 485918008272 FeS/SAM binding site; other site 485918008273 agmatinase; Region: agmatinase; TIGR01230 485918008274 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 485918008275 putative active site [active] 485918008276 Mn binding site [ion binding]; other site 485918008277 CcmE; Region: CcmE; cl00994 485918008278 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 485918008279 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918008280 Domain of unknown function (DUF4294); Region: DUF4294; pfam14127 485918008281 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918008282 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 485918008283 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 485918008284 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 485918008285 dimer interface [polypeptide binding]; other site 485918008286 decamer (pentamer of dimers) interface [polypeptide binding]; other site 485918008287 catalytic triad [active] 485918008288 peroxidatic and resolving cysteines [active] 485918008289 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 485918008290 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 485918008291 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 485918008292 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 485918008293 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 485918008294 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 485918008295 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 485918008296 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 485918008297 Cupin-like domain; Region: Cupin_8; pfam13621 485918008298 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 485918008299 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 485918008300 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 485918008301 FeS/SAM binding site; other site 485918008302 TRAM domain; Region: TRAM; pfam01938 485918008303 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 485918008304 DEAD-like helicases superfamily; Region: DEXDc; smart00487 485918008305 ATP binding site [chemical binding]; other site 485918008306 Mg++ binding site [ion binding]; other site 485918008307 motif III; other site 485918008308 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 485918008309 nucleotide binding region [chemical binding]; other site 485918008310 ATP-binding site [chemical binding]; other site 485918008311 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 485918008312 RNA binding site [nucleotide binding]; other site 485918008313 glycogen branching enzyme; Provisional; Region: PRK12313 485918008314 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 485918008315 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 485918008316 active site 485918008317 catalytic site [active] 485918008318 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 485918008319 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 485918008320 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918008321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 485918008322 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 485918008323 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 485918008324 active site 485918008325 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 485918008326 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 485918008327 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 485918008328 trimer interface [polypeptide binding]; other site 485918008329 active site 485918008330 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 485918008331 catalytic site [active] 485918008332 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 485918008333 Two component regulator propeller; Region: Reg_prop; pfam07494 485918008334 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 485918008335 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 485918008336 Histidine kinase; Region: HisKA_3; pfam07730 485918008337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918008338 ATP binding site [chemical binding]; other site 485918008339 Mg2+ binding site [ion binding]; other site 485918008340 G-X-G motif; other site 485918008341 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918008342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918008343 active site 485918008344 phosphorylation site [posttranslational modification] 485918008345 intermolecular recognition site; other site 485918008346 dimerization interface [polypeptide binding]; other site 485918008347 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918008348 DNA binding residues [nucleotide binding] 485918008349 dimerization interface [polypeptide binding]; other site 485918008350 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 485918008351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918008352 ATP binding site [chemical binding]; other site 485918008353 Mg2+ binding site [ion binding]; other site 485918008354 G-X-G motif; other site 485918008355 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 485918008356 ATP binding site [chemical binding]; other site 485918008357 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 485918008358 active site 485918008359 metal binding site [ion binding]; metal-binding site 485918008360 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 485918008361 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 485918008362 Protein of unknown function; Region: DUF3658; pfam12395 485918008363 Cupin domain; Region: Cupin_2; cl17218 485918008364 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 485918008365 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 485918008366 CAP-like domain; other site 485918008367 active site 485918008368 primary dimer interface [polypeptide binding]; other site 485918008369 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 485918008370 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 485918008371 active site 485918008372 motif I; other site 485918008373 motif II; other site 485918008374 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 485918008375 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 485918008376 Substrate binding site; other site 485918008377 Mg++ binding site; other site 485918008378 metal-binding site 485918008379 Mg++ binding site; other site 485918008380 metal-binding site 485918008381 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 485918008382 dimer interface [polypeptide binding]; other site 485918008383 active site 485918008384 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 485918008385 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 485918008386 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 485918008387 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 485918008388 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 485918008389 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 485918008390 Ligand binding site; other site 485918008391 Putative Catalytic site; other site 485918008392 DXD motif; other site 485918008393 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 485918008394 dihydroorotase; Validated; Region: pyrC; PRK09357 485918008395 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 485918008396 active site 485918008397 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918008398 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918008399 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918008400 DNA binding residues [nucleotide binding] 485918008401 FecR protein; Region: FecR; pfam04773 485918008402 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918008403 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918008404 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918008405 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918008406 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918008407 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918008408 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 485918008409 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 485918008410 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 485918008411 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918008412 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918008413 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918008414 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 485918008415 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 485918008416 DXD motif; other site 485918008417 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 485918008418 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 485918008419 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 485918008420 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 485918008421 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 485918008422 oxidoreductase; Provisional; Region: PRK06128 485918008423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918008424 NAD(P) binding site [chemical binding]; other site 485918008425 active site 485918008426 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 485918008427 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 485918008428 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918008429 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 485918008430 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 485918008431 N-terminal plug; other site 485918008432 ligand-binding site [chemical binding]; other site 485918008433 Methyltransferase domain; Region: Methyltransf_23; pfam13489 485918008434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918008435 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918008436 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918008437 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918008438 short chain dehydrogenase; Validated; Region: PRK06182 485918008439 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918008440 NADP binding site [chemical binding]; other site 485918008441 active site 485918008442 steroid binding site; other site 485918008443 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 485918008444 classical (c) SDRs; Region: SDR_c; cd05233 485918008445 NAD(P) binding site [chemical binding]; other site 485918008446 active site 485918008447 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918008448 glucose-1-dehydrogenase; Provisional; Region: PRK06947 485918008449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918008450 NAD(P) binding site [chemical binding]; other site 485918008451 active site 485918008452 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 485918008453 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 485918008454 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 485918008455 DNA binding site [nucleotide binding] 485918008456 Competence protein CoiA-like family; Region: CoiA; cl11541 485918008457 Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425 485918008458 active site 485918008459 metal binding site [ion binding]; metal-binding site 485918008460 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 485918008461 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918008462 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918008463 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918008464 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918008465 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918008466 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918008467 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918008468 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918008469 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918008470 catalytic residues [active] 485918008471 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 485918008472 Catalytic domain of Protein Kinases; Region: PKc; cd00180 485918008473 Protein kinase domain; Region: Pkinase; pfam00069 485918008474 active site 485918008475 ATP binding site [chemical binding]; other site 485918008476 substrate binding site [chemical binding]; other site 485918008477 activation loop (A-loop); other site 485918008478 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cd04434 485918008479 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 485918008480 active site 485918008481 zinc binding site [ion binding]; other site 485918008482 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918008483 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918008484 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918008485 FecR protein; Region: FecR; pfam04773 485918008486 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 485918008487 FecR protein; Region: FecR; pfam04773 485918008488 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918008489 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918008490 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918008491 DNA binding residues [nucleotide binding] 485918008492 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918008493 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918008494 catalytic residues [active] 485918008495 Secretin and TonB N terminus short domain; Region: STN; smart00965 485918008496 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918008497 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918008498 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918008499 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918008500 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918008501 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918008502 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918008503 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918008504 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918008505 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918008506 phosphorylation site [posttranslational modification] 485918008507 dimer interface [polypeptide binding]; other site 485918008508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918008509 ATP binding site [chemical binding]; other site 485918008510 Mg2+ binding site [ion binding]; other site 485918008511 G-X-G motif; other site 485918008512 Response regulator receiver domain; Region: Response_reg; pfam00072 485918008513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918008514 active site 485918008515 phosphorylation site [posttranslational modification] 485918008516 intermolecular recognition site; other site 485918008517 dimerization interface [polypeptide binding]; other site 485918008518 UbiA prenyltransferase family; Region: UbiA; pfam01040 485918008519 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 485918008520 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 485918008521 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 485918008522 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 485918008523 Part of AAA domain; Region: AAA_19; pfam13245 485918008524 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 485918008525 Family description; Region: UvrD_C_2; pfam13538 485918008526 AAA ATPase domain; Region: AAA_15; pfam13175 485918008527 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918008528 Walker A/P-loop; other site 485918008529 ATP binding site [chemical binding]; other site 485918008530 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 485918008531 putative active site [active] 485918008532 putative metal-binding site [ion binding]; other site 485918008533 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 485918008534 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 485918008535 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 485918008536 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918008537 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918008538 Secretin and TonB N terminus short domain; Region: STN; smart00965 485918008539 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918008540 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918008541 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918008542 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918008543 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918008544 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918008545 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918008546 DNA binding residues [nucleotide binding] 485918008547 FecR protein; Region: FecR; pfam04773 485918008548 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 485918008549 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918008550 FecR protein; Region: FecR; pfam04773 485918008551 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918008552 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918008553 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918008554 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918008555 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918008556 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918008557 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 485918008558 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918008559 DNA binding residues [nucleotide binding] 485918008560 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918008561 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918008562 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918008563 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918008564 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918008565 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918008566 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918008567 FecR protein; Region: FecR; pfam04773 485918008568 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918008569 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918008570 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918008571 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918008572 DNA binding residues [nucleotide binding] 485918008573 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 485918008574 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 485918008575 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 485918008576 Prokaryotic Ubiquitin; Region: Prok_Ub; cl14020 485918008577 Prokaryotic E2 family D; Region: Prok-E2_D; cl14019 485918008578 PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736 485918008579 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 485918008580 ATP binding site [chemical binding]; other site 485918008581 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 485918008582 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 485918008583 active site 485918008584 DNA binding site [nucleotide binding] 485918008585 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 485918008586 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 485918008587 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 485918008588 active site 485918008589 PHP Thumb interface [polypeptide binding]; other site 485918008590 hypothetical protein; Provisional; Region: PRK06126 485918008591 KDPG and KHG aldolase; Region: Aldolase; cl17259 485918008592 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 485918008593 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 485918008594 active site 485918008595 DNA binding site [nucleotide binding] 485918008596 DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776 485918008597 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 485918008598 DNA binding site [nucleotide binding] 485918008599 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 485918008600 nucleotide binding site [chemical binding]; other site 485918008601 Divergent AAA domain; Region: AAA_4; pfam04326 485918008602 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 485918008603 active site 485918008604 DNA binding site [nucleotide binding] 485918008605 Int/Topo IB signature motif; other site 485918008606 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 485918008607 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 485918008608 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 485918008609 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 485918008610 active site 485918008611 substrate binding site [chemical binding]; other site 485918008612 Mg2+ binding site [ion binding]; other site 485918008613 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 485918008614 Surface antigen; Region: Bac_surface_Ag; pfam01103 485918008615 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 485918008616 putative hydrophobic ligand binding site [chemical binding]; other site 485918008617 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918008618 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918008619 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918008620 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 485918008621 active site 485918008622 metal binding site [ion binding]; metal-binding site 485918008623 Protein of unknown function (DUF2167); Region: DUF2167; pfam09935 485918008624 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 485918008625 TPR repeat; Region: TPR_11; pfam13414 485918008626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918008627 binding surface 485918008628 TPR motif; other site 485918008629 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 485918008630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918008631 binding surface 485918008632 TPR motif; other site 485918008633 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 485918008634 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 485918008635 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918008636 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918008637 periplasmic chaperone; Provisional; Region: PRK10780 485918008638 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 485918008639 Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120 485918008640 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 485918008641 YceI-like domain; Region: YceI; pfam04264 485918008642 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 485918008643 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 485918008644 metal binding site [ion binding]; metal-binding site 485918008645 putative dimer interface [polypeptide binding]; other site 485918008646 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 485918008647 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 485918008648 active site 485918008649 catalytic residues [active] 485918008650 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 485918008651 Ribokinase-like subgroup D. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_D; cd01937 485918008652 substrate binding site [chemical binding]; other site 485918008653 ATP binding site [chemical binding]; other site 485918008654 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 485918008655 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 485918008656 substrate binding [chemical binding]; other site 485918008657 active site 485918008658 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 485918008659 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 485918008660 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 485918008661 active site 485918008662 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918008663 FtsX-like permease family; Region: FtsX; pfam02687 485918008664 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918008665 FtsX-like permease family; Region: FtsX; pfam02687 485918008666 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 485918008667 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 485918008668 heme-binding site [chemical binding]; other site 485918008669 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918008670 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 485918008671 ligand binding site [chemical binding]; other site 485918008672 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 485918008673 putative switch regulator; other site 485918008674 non-specific DNA interactions [nucleotide binding]; other site 485918008675 DNA binding site [nucleotide binding] 485918008676 sequence specific DNA binding site [nucleotide binding]; other site 485918008677 putative cAMP binding site [chemical binding]; other site 485918008678 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 485918008679 Surface antigen; Region: Bac_surface_Ag; pfam01103 485918008680 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 485918008681 active site pocket [active] 485918008682 oxyanion hole [active] 485918008683 catalytic triad [active] 485918008684 active site nucleophile [active] 485918008685 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 485918008686 NADH(P)-binding; Region: NAD_binding_10; pfam13460 485918008687 NAD binding site [chemical binding]; other site 485918008688 substrate binding site [chemical binding]; other site 485918008689 putative active site [active] 485918008690 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918008691 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 485918008692 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 485918008693 Methyltransferase domain; Region: Methyltransf_12; pfam08242 485918008694 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 485918008695 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; cl17639 485918008696 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 485918008697 active site 485918008698 metal binding site [ion binding]; metal-binding site 485918008699 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918008700 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918008701 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918008702 DNA binding residues [nucleotide binding] 485918008703 FecR protein; Region: FecR; pfam04773 485918008704 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918008705 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918008706 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918008707 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918008708 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918008709 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918008710 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918008711 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 485918008712 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918008713 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918008714 catalytic residues [active] 485918008715 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 485918008716 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 485918008717 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 485918008718 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 485918008719 Sulfatase; Region: Sulfatase; pfam00884 485918008720 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 485918008721 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918008722 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918008723 short chain dehydrogenase; Provisional; Region: PRK06180 485918008724 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918008725 NADP binding site [chemical binding]; other site 485918008726 active site 485918008727 steroid binding site; other site 485918008728 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918008729 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918008730 short chain dehydrogenase; Provisional; Region: PRK06179 485918008731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918008732 NAD(P) binding site [chemical binding]; other site 485918008733 active site 485918008734 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918008735 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 485918008736 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 485918008737 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918008738 Walker A/P-loop; other site 485918008739 ATP binding site [chemical binding]; other site 485918008740 Q-loop/lid; other site 485918008741 ABC transporter signature motif; other site 485918008742 Walker B; other site 485918008743 D-loop; other site 485918008744 H-loop/switch region; other site 485918008745 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 485918008746 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 485918008747 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918008748 Walker A/P-loop; other site 485918008749 ATP binding site [chemical binding]; other site 485918008750 Q-loop/lid; other site 485918008751 ABC transporter signature motif; other site 485918008752 Walker B; other site 485918008753 D-loop; other site 485918008754 H-loop/switch region; other site 485918008755 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 485918008756 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 485918008757 Transcriptional regulators [Transcription]; Region: FadR; COG2186 485918008758 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 485918008759 DNA-binding site [nucleotide binding]; DNA binding site 485918008760 FCD domain; Region: FCD; pfam07729 485918008761 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 485918008762 Fatty acid desaturase; Region: FA_desaturase; pfam00487 485918008763 Di-iron ligands [ion binding]; other site 485918008764 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 485918008765 Repair protein; Region: Repair_PSII; pfam04536 485918008766 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 485918008767 Permease; Region: Permease; pfam02405 485918008768 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 485918008769 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 485918008770 Walker A/P-loop; other site 485918008771 ATP binding site [chemical binding]; other site 485918008772 Q-loop/lid; other site 485918008773 ABC transporter signature motif; other site 485918008774 Walker B; other site 485918008775 D-loop; other site 485918008776 H-loop/switch region; other site 485918008777 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 485918008778 mce related protein; Region: MCE; pfam02470 485918008779 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 485918008780 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 485918008781 putative NAD(P) binding site [chemical binding]; other site 485918008782 catalytic Zn binding site [ion binding]; other site 485918008783 structural Zn binding site [ion binding]; other site 485918008784 Sulfatase; Region: Sulfatase; cl17466 485918008785 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 485918008786 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918008787 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918008788 dimer interface [polypeptide binding]; other site 485918008789 phosphorylation site [posttranslational modification] 485918008790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918008791 ATP binding site [chemical binding]; other site 485918008792 Mg2+ binding site [ion binding]; other site 485918008793 G-X-G motif; other site 485918008794 acyl-coenzyme A oxidase; Region: PLN02526 485918008795 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 485918008796 active site 485918008797 YceI-like domain; Region: YceI; pfam04264 485918008798 Uncharacterized conserved protein [Function unknown]; Region: COG2353 485918008799 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918008800 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918008801 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 485918008802 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 485918008803 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918008804 NAD(P) binding site [chemical binding]; other site 485918008805 active site 485918008806 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 485918008807 Predicted transporter component [General function prediction only]; Region: COG2391 485918008808 Sulphur transport; Region: Sulf_transp; pfam04143 485918008809 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 485918008810 MarR family; Region: MarR_2; cl17246 485918008811 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 485918008812 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 485918008813 TrkA-C domain; Region: TrkA_C; pfam02080 485918008814 TrkA-C domain; Region: TrkA_C; pfam02080 485918008815 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 485918008816 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 485918008817 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 485918008818 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 485918008819 CheB methylesterase; Region: CheB_methylest; pfam01339 485918008820 Response regulator receiver domain; Region: Response_reg; pfam00072 485918008821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918008822 active site 485918008823 phosphorylation site [posttranslational modification] 485918008824 intermolecular recognition site; other site 485918008825 dimerization interface [polypeptide binding]; other site 485918008826 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 485918008827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918008828 dimer interface [polypeptide binding]; other site 485918008829 phosphorylation site [posttranslational modification] 485918008830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918008831 ATP binding site [chemical binding]; other site 485918008832 Mg2+ binding site [ion binding]; other site 485918008833 G-X-G motif; other site 485918008834 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 485918008835 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 485918008836 metal binding site [ion binding]; metal-binding site 485918008837 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 485918008838 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918008839 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 485918008840 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918008841 Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632 485918008842 dimer interface [polypeptide binding]; other site 485918008843 putative inhibitory loop; other site 485918008844 Bacterial SH3 domain; Region: SH3_3; pfam08239 485918008845 BON domain; Region: BON; pfam04972 485918008846 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 485918008847 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 485918008848 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 485918008849 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 485918008850 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 485918008851 catalytic residue [active] 485918008852 FeS assembly protein SufD; Region: sufD; TIGR01981 485918008853 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 485918008854 FeS assembly ATPase SufC; Region: sufC; TIGR01978 485918008855 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 485918008856 Walker A/P-loop; other site 485918008857 ATP binding site [chemical binding]; other site 485918008858 Q-loop/lid; other site 485918008859 ABC transporter signature motif; other site 485918008860 Walker B; other site 485918008861 D-loop; other site 485918008862 H-loop/switch region; other site 485918008863 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 485918008864 putative ABC transporter; Region: ycf24; CHL00085 485918008865 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 485918008866 Predicted flavoprotein [General function prediction only]; Region: COG0431 485918008867 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 485918008868 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 485918008869 Predicted transcriptional regulator [Transcription]; Region: COG2345 485918008870 Predicted membrane protein [Function unknown]; Region: COG2510 485918008871 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 485918008872 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918008873 Coenzyme A binding pocket [chemical binding]; other site 485918008874 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 485918008875 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 485918008876 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 485918008877 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918008878 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 485918008879 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 485918008880 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 485918008881 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 485918008882 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 485918008883 G1 box; other site 485918008884 putative GEF interaction site [polypeptide binding]; other site 485918008885 GTP/Mg2+ binding site [chemical binding]; other site 485918008886 Switch I region; other site 485918008887 G2 box; other site 485918008888 G3 box; other site 485918008889 Switch II region; other site 485918008890 G4 box; other site 485918008891 G5 box; other site 485918008892 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 485918008893 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918008894 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 485918008895 FtsX-like permease family; Region: FtsX; pfam02687 485918008896 UGMP family protein; Validated; Region: PRK09604 485918008897 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 485918008898 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 485918008899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918008900 S-adenosylmethionine binding site [chemical binding]; other site 485918008901 Saccharopine Dehydrogenase like proteins; Region: SDH_like; cd05199 485918008902 active site 485918008903 ligand binding site [chemical binding]; other site 485918008904 NAD(P) binding site [chemical binding]; other site 485918008905 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 485918008906 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918008907 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918008908 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918008909 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 485918008910 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 485918008911 putative catalytic site [active] 485918008912 putative phosphate binding site [ion binding]; other site 485918008913 active site 485918008914 metal binding site A [ion binding]; metal-binding site 485918008915 DNA binding site [nucleotide binding] 485918008916 putative AP binding site [nucleotide binding]; other site 485918008917 putative metal binding site B [ion binding]; other site 485918008918 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 485918008919 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 485918008920 putative active site [active] 485918008921 putative PHP Thumb interface [polypeptide binding]; other site 485918008922 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 485918008923 generic binding surface II; other site 485918008924 generic binding surface I; other site 485918008925 DNA Polymerase Y-family; Region: PolY_like; cd03468 485918008926 active site 485918008927 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 485918008928 DNA binding site [nucleotide binding] 485918008929 Uncharacterized conserved protein [Function unknown]; Region: COG4544 485918008930 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918008931 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918008932 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918008933 SnoaL-like domain; Region: SnoaL_2; pfam12680 485918008934 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918008935 short chain dehydrogenase; Provisional; Region: PRK08263 485918008936 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918008937 NADP binding site [chemical binding]; other site 485918008938 active site 485918008939 steroid binding site; other site 485918008940 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 485918008941 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 485918008942 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918008943 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 485918008944 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 485918008945 active site 485918008946 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918008947 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918008948 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 485918008949 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 485918008950 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 485918008951 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 485918008952 Active site serine [active] 485918008953 Histidine kinase; Region: His_kinase; pfam06580 485918008954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918008955 Response regulator receiver domain; Region: Response_reg; pfam00072 485918008956 active site 485918008957 phosphorylation site [posttranslational modification] 485918008958 intermolecular recognition site; other site 485918008959 dimerization interface [polypeptide binding]; other site 485918008960 LytTr DNA-binding domain; Region: LytTR; smart00850 485918008961 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 485918008962 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 485918008963 active site 485918008964 zinc binding site [ion binding]; other site 485918008965 transcriptional activator RfaH; Region: RfaH; TIGR01955 485918008966 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 485918008967 acyl-CoA synthetase; Validated; Region: PRK09192 485918008968 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 485918008969 acyl-activating enzyme (AAE) consensus motif; other site 485918008970 putative AMP binding site [chemical binding]; other site 485918008971 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918008972 Condensation domain; Region: Condensation; pfam00668 485918008973 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918008974 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918008975 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918008976 acyl-activating enzyme (AAE) consensus motif; other site 485918008977 AMP binding site [chemical binding]; other site 485918008978 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918008979 Condensation domain; Region: Condensation; pfam00668 485918008980 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918008981 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918008982 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918008983 acyl-activating enzyme (AAE) consensus motif; other site 485918008984 AMP binding site [chemical binding]; other site 485918008985 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918008986 Condensation domain; Region: Condensation; pfam00668 485918008987 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918008988 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918008989 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918008990 acyl-activating enzyme (AAE) consensus motif; other site 485918008991 AMP binding site [chemical binding]; other site 485918008992 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918008993 Condensation domain; Region: Condensation; pfam00668 485918008994 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918008995 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918008996 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 485918008997 acyl-activating enzyme (AAE) consensus motif; other site 485918008998 AMP binding site [chemical binding]; other site 485918008999 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918009000 Condensation domain; Region: Condensation; pfam00668 485918009001 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918009002 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918009003 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 485918009004 FkbH-like domain; Region: FkbH; TIGR01686 485918009005 HAD-superfamily phosphatase, subfamily IIIC; Region: HAD-SF-IIIC; TIGR01681 485918009006 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 485918009007 dimer interface [polypeptide binding]; other site 485918009008 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918009009 substrate binding site [chemical binding]; other site 485918009010 metal binding site [ion binding]; metal-binding site 485918009011 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918009012 Condensation domain; Region: Condensation; pfam00668 485918009013 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918009014 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918009015 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918009016 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 485918009017 acyl-activating enzyme (AAE) consensus motif; other site 485918009018 AMP binding site [chemical binding]; other site 485918009019 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918009020 Condensation domain; Region: Condensation; pfam00668 485918009021 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918009022 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918009023 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 485918009024 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 485918009025 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918009026 acyl-activating enzyme (AAE) consensus motif; other site 485918009027 AMP binding site [chemical binding]; other site 485918009028 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918009029 Condensation domain; Region: Condensation; pfam00668 485918009030 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918009031 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918009032 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 485918009033 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 485918009034 active site 485918009035 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 485918009036 dimer interface [polypeptide binding]; other site 485918009037 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 485918009038 Ligand Binding Site [chemical binding]; other site 485918009039 Molecular Tunnel; other site 485918009040 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 485918009041 aspartate racemase; Region: asp_race; TIGR00035 485918009042 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 485918009043 B12 binding site [chemical binding]; other site 485918009044 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 485918009045 substrate binding site [chemical binding]; other site 485918009046 B12 cofactor binding site [chemical binding]; other site 485918009047 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 485918009048 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 485918009049 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918009050 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 485918009051 acyl-activating enzyme (AAE) consensus motif; other site 485918009052 AMP binding site [chemical binding]; other site 485918009053 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918009054 Condensation domain; Region: Condensation; pfam00668 485918009055 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918009056 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918009057 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 485918009058 active site 485918009059 iron coordination sites [ion binding]; other site 485918009060 substrate binding pocket [chemical binding]; other site 485918009061 Condensation domain; Region: Condensation; pfam00668 485918009062 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918009063 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 485918009064 acyl-activating enzyme (AAE) consensus motif; other site 485918009065 AMP binding site [chemical binding]; other site 485918009066 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918009067 Condensation domain; Region: Condensation; pfam00668 485918009068 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918009069 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918009070 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 485918009071 Methyltransferase domain; Region: Methyltransf_31; pfam13847 485918009072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918009073 S-adenosylmethionine binding site [chemical binding]; other site 485918009074 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918009075 acyl-activating enzyme (AAE) consensus motif; other site 485918009076 AMP binding site [chemical binding]; other site 485918009077 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918009078 Condensation domain; Region: Condensation; pfam00668 485918009079 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918009080 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918009081 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 485918009082 active site 485918009083 iron coordination sites [ion binding]; other site 485918009084 substrate binding pocket [chemical binding]; other site 485918009085 Condensation domain; Region: Condensation; pfam00668 485918009086 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918009087 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 485918009088 acyl-activating enzyme (AAE) consensus motif; other site 485918009089 AMP binding site [chemical binding]; other site 485918009090 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918009091 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 485918009092 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 485918009093 active site 485918009094 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 485918009095 KR domain; Region: KR; pfam08659 485918009096 putative NADP binding site [chemical binding]; other site 485918009097 active site 485918009098 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918009099 Condensation domain; Region: Condensation; pfam00668 485918009100 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918009101 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918009102 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 485918009103 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 485918009104 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 485918009105 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 485918009106 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 485918009107 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 485918009108 active site 485918009109 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 485918009110 active site 485918009111 FkbH-like domain; Region: FkbH; TIGR01686 485918009112 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 485918009113 active site 485918009114 motif I; other site 485918009115 motif II; other site 485918009116 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918009117 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 485918009118 acyl-activating enzyme (AAE) consensus motif; other site 485918009119 AMP binding site [chemical binding]; other site 485918009120 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918009121 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 485918009122 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 485918009123 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 485918009124 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 485918009125 active site 485918009126 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918009127 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 485918009128 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 485918009129 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 485918009130 catalytic residue [active] 485918009131 Condensation domain; Region: Condensation; pfam00668 485918009132 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918009133 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 485918009134 AMP binding site [chemical binding]; other site 485918009135 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918009136 Condensation domain; Region: Condensation; pfam00668 485918009137 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918009138 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918009139 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918009140 acyl-activating enzyme (AAE) consensus motif; other site 485918009141 AMP binding site [chemical binding]; other site 485918009142 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918009143 Condensation domain; Region: Condensation; pfam00668 485918009144 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918009145 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918009146 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918009147 acyl-activating enzyme (AAE) consensus motif; other site 485918009148 AMP binding site [chemical binding]; other site 485918009149 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918009150 Condensation domain; Region: Condensation; pfam00668 485918009151 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918009152 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918009153 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918009154 acyl-activating enzyme (AAE) consensus motif; other site 485918009155 AMP binding site [chemical binding]; other site 485918009156 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918009157 Condensation domain; Region: Condensation; pfam00668 485918009158 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918009159 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918009160 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918009161 acyl-activating enzyme (AAE) consensus motif; other site 485918009162 AMP binding site [chemical binding]; other site 485918009163 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918009164 Condensation domain; Region: Condensation; pfam00668 485918009165 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918009166 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918009167 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918009168 acyl-activating enzyme (AAE) consensus motif; other site 485918009169 AMP binding site [chemical binding]; other site 485918009170 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918009171 Thioesterase domain; Region: Thioesterase; pfam00975 485918009172 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 485918009173 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 485918009174 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 485918009175 Walker A/P-loop; other site 485918009176 ATP binding site [chemical binding]; other site 485918009177 Q-loop/lid; other site 485918009178 ABC transporter signature motif; other site 485918009179 Walker B; other site 485918009180 D-loop; other site 485918009181 H-loop/switch region; other site 485918009182 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 485918009183 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 485918009184 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 485918009185 Predicted membrane protein (DUF2070); Region: DUF2070; pfam09843 485918009186 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 485918009187 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918009188 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918009189 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918009190 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 485918009191 Peptidase family M1; Region: Peptidase_M1; pfam01433 485918009192 Zn binding site [ion binding]; other site 485918009193 HEAT repeats; Region: HEAT_2; pfam13646 485918009194 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 485918009195 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 485918009196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918009197 putative transporter; Provisional; Region: PRK10504 485918009198 putative substrate translocation pore; other site 485918009199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918009200 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 485918009201 Predicted integral membrane protein [Function unknown]; Region: COG5637 485918009202 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 485918009203 putative hydrophobic ligand binding site [chemical binding]; other site 485918009204 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 485918009205 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 485918009206 Class I ribonucleotide reductase; Region: RNR_I; cd01679 485918009207 active site 485918009208 dimer interface [polypeptide binding]; other site 485918009209 catalytic residues [active] 485918009210 effector binding site; other site 485918009211 R2 peptide binding site; other site 485918009212 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 485918009213 dimer interface [polypeptide binding]; other site 485918009214 putative radical transfer pathway; other site 485918009215 diiron center [ion binding]; other site 485918009216 tyrosyl radical; other site 485918009217 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918009218 FtsX-like permease family; Region: FtsX; pfam02687 485918009219 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918009220 FtsX-like permease family; Region: FtsX; pfam02687 485918009221 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 485918009222 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 485918009223 Caspase domain; Region: Peptidase_C14; pfam00656 485918009224 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 485918009225 FOG: WD40 repeat [General function prediction only]; Region: COG2319 485918009226 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 485918009227 structural tetrad; other site 485918009228 FOG: WD40 repeat [General function prediction only]; Region: COG2319 485918009229 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 485918009230 structural tetrad; other site 485918009231 Caspase domain; Region: Peptidase_C14; pfam00656 485918009232 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 485918009233 active site 485918009234 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 485918009235 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 485918009236 putative active site [active] 485918009237 putative FMN binding site [chemical binding]; other site 485918009238 putative substrate binding site [chemical binding]; other site 485918009239 putative catalytic residue [active] 485918009240 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 485918009241 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 485918009242 AsnC family; Region: AsnC_trans_reg; pfam01037 485918009243 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 485918009244 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 485918009245 tetrameric interface [polypeptide binding]; other site 485918009246 NAD binding site [chemical binding]; other site 485918009247 catalytic residues [active] 485918009248 hypothetical protein; Provisional; Region: PRK06062 485918009249 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 485918009250 inhibitor-cofactor binding pocket; inhibition site 485918009251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918009252 catalytic residue [active] 485918009253 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 485918009254 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 485918009255 Na binding site [ion binding]; other site 485918009256 putative substrate binding site [chemical binding]; other site 485918009257 phenylhydantoinase; Validated; Region: PRK08323 485918009258 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 485918009259 tetramer interface [polypeptide binding]; other site 485918009260 active site 485918009261 mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases); Region: ML_beta-AS_like; cd07568 485918009262 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 485918009263 putative active site [active] 485918009264 catalytic triad [active] 485918009265 multimer interface [polypeptide binding]; other site 485918009266 dimer interface [polypeptide binding]; other site 485918009267 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 485918009268 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 485918009269 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 485918009270 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 485918009271 homodimer interface [polypeptide binding]; other site 485918009272 active site 485918009273 FMN binding site [chemical binding]; other site 485918009274 substrate binding site [chemical binding]; other site 485918009275 4Fe-4S binding domain; Region: Fer4; cl02805 485918009276 Phosphoesterase family; Region: Phosphoesterase; pfam04185 485918009277 Phosphoesterase family; Region: Phosphoesterase; pfam04185 485918009278 Domain of unknown function (DUF756); Region: DUF756; pfam05506 485918009279 Domain of unknown function (DUF756); Region: DUF756; pfam05506 485918009280 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918009281 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918009282 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918009283 FecR protein; Region: FecR; pfam04773 485918009284 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918009285 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918009286 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918009287 DNA binding residues [nucleotide binding] 485918009288 DinB superfamily; Region: DinB_2; pfam12867 485918009289 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 485918009290 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 485918009291 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 485918009292 Ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding domain of the alpha/beta class and a discrete (usually N-terminal) domain which varies in orientation with respect to the NAD(P) binding domain. The N-terminal region...; Region: FNR_like_1; cd06196 485918009293 FAD binding pocket [chemical binding]; other site 485918009294 FAD binding motif [chemical binding]; other site 485918009295 phosphate binding motif [ion binding]; other site 485918009296 beta-alpha-beta structure motif; other site 485918009297 NAD binding pocket [chemical binding]; other site 485918009298 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918009299 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918009300 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 485918009301 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 485918009302 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918009303 TPR motif; other site 485918009304 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918009305 binding surface 485918009306 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918009307 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 485918009308 Histidine kinase; Region: HisKA_2; pfam07568 485918009309 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918009310 ATP binding site [chemical binding]; other site 485918009311 Mg2+ binding site [ion binding]; other site 485918009312 G-X-G motif; other site 485918009313 Right handed beta helix region; Region: Beta_helix; pfam13229 485918009314 hypothetical protein; Provisional; Region: PRK07236 485918009315 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 485918009316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918009317 putative substrate translocation pore; other site 485918009318 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918009319 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918009320 ligand binding site [chemical binding]; other site 485918009321 K+ potassium transporter; Region: K_trans; pfam02705 485918009322 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 485918009323 catalytic motif [active] 485918009324 Catalytic residue [active] 485918009325 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 485918009326 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 485918009327 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 485918009328 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 485918009329 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 485918009330 PLD-like domain; Region: PLDc_2; pfam13091 485918009331 putative active site [active] 485918009332 catalytic site [active] 485918009333 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_2; cd09128 485918009334 PLD-like domain; Region: PLDc_2; pfam13091 485918009335 putative active site [active] 485918009336 putative catalytic site [active] 485918009337 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 485918009338 HD domain; Region: HD_4; pfam13328 485918009339 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 485918009340 Predicted membrane protein [Function unknown]; Region: COG4682 485918009341 yiaA/B two helix domain; Region: YiaAB; pfam05360 485918009342 yiaA/B two helix domain; Region: YiaAB; pfam05360 485918009343 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918009344 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918009345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918009346 NAD(P) binding site [chemical binding]; other site 485918009347 active site 485918009348 SnoaL-like domain; Region: SnoaL_2; pfam12680 485918009349 oxidoreductase; Provisional; Region: PRK06196 485918009350 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 485918009351 putative NAD(P) binding site [chemical binding]; other site 485918009352 active site 485918009353 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 485918009354 active site 485918009355 Transposase; Region: HTH_Tnp_1; pfam01527 485918009356 HTH-like domain; Region: HTH_21; pfam13276 485918009357 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 485918009358 Integrase core domain; Region: rve; pfam00665 485918009359 Integrase core domain; Region: rve_3; pfam13683 485918009360 EthD domain; Region: EthD; pfam07110 485918009361 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918009362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918009363 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 485918009364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918009365 Walker A/P-loop; other site 485918009366 ATP binding site [chemical binding]; other site 485918009367 Q-loop/lid; other site 485918009368 ABC transporter signature motif; other site 485918009369 Walker B; other site 485918009370 D-loop; other site 485918009371 H-loop/switch region; other site 485918009372 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 485918009373 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 485918009374 Cupin domain; Region: Cupin_2; pfam07883 485918009375 AAA ATPase domain; Region: AAA_15; pfam13175 485918009376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918009377 Walker A/P-loop; other site 485918009378 ATP binding site [chemical binding]; other site 485918009379 Q-loop/lid; other site 485918009380 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 485918009381 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 485918009382 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 485918009383 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 485918009384 non-specific DNA binding site [nucleotide binding]; other site 485918009385 salt bridge; other site 485918009386 sequence-specific DNA binding site [nucleotide binding]; other site 485918009387 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 485918009388 P-loop containing region of AAA domain; Region: AAA_29; cl17516 485918009389 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918009390 Walker A/P-loop; other site 485918009391 ATP binding site [chemical binding]; other site 485918009392 Transposase; Region: HTH_Tnp_1; pfam01527 485918009393 HTH-like domain; Region: HTH_21; pfam13276 485918009394 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 485918009395 Integrase core domain; Region: rve; pfam00665 485918009396 Integrase core domain; Region: rve_3; pfam13683 485918009397 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 485918009398 Winged helix-turn helix; Region: HTH_29; pfam13551 485918009399 Integrase core domain; Region: rve; pfam00665 485918009400 Integrase core domain; Region: rve_3; pfam13683 485918009401 Transposase; Region: HTH_Tnp_1; pfam01527 485918009402 HTH-like domain; Region: HTH_21; pfam13276 485918009403 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 485918009404 Integrase core domain; Region: rve; pfam00665 485918009405 Integrase core domain; Region: rve_3; pfam13683 485918009406 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918009407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 485918009408 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 485918009409 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 485918009410 catalytic residues [active] 485918009411 catalytic nucleophile [active] 485918009412 Recombinase; Region: Recombinase; pfam07508 485918009413 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 485918009414 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 485918009415 putative NAD(P) binding site [chemical binding]; other site 485918009416 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918009417 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918009418 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 485918009419 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 485918009420 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 485918009421 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 485918009422 active site 485918009423 substrate binding site [chemical binding]; other site 485918009424 ATP binding site [chemical binding]; other site 485918009425 Phosphotransferase enzyme family; Region: APH; pfam01636 485918009426 MarR family; Region: MarR_2; cl17246 485918009427 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918009428 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918009429 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 485918009430 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918009431 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918009432 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918009433 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 485918009434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918009435 putative substrate translocation pore; other site 485918009436 glycosyl hydrolase 64 family; Region: GH64-like; cd09214 485918009437 substrate binding pocket [chemical binding]; other site 485918009438 catalytic residues [active] 485918009439 Beta/Gamma crystallin; Region: Crystall; cl02528 485918009440 Beta/Gamma crystallin; Region: Crystall; cl02528 485918009441 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 485918009442 Ca binding site [ion binding]; other site 485918009443 ligand binding site I [chemical binding]; other site 485918009444 homodimer interface [polypeptide binding]; other site 485918009445 ligand binding site II [chemical binding]; other site 485918009446 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918009447 Transcriptional regulators [Transcription]; Region: PurR; COG1609 485918009448 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 485918009449 DNA binding site [nucleotide binding] 485918009450 domain linker motif; other site 485918009451 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 485918009452 dimerization interface [polypeptide binding]; other site 485918009453 ligand binding site [chemical binding]; other site 485918009454 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918009455 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918009456 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918009457 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918009458 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918009459 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918009460 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 485918009461 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 485918009462 Na binding site [ion binding]; other site 485918009463 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 485918009464 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 485918009465 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 485918009466 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918009467 Coenzyme A binding pocket [chemical binding]; other site 485918009468 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 485918009469 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 485918009470 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 485918009471 Uncharacterized conserved protein [Function unknown]; Region: COG2128 485918009472 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 485918009473 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 485918009474 DNA-binding site [nucleotide binding]; DNA binding site 485918009475 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 485918009476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918009477 homodimer interface [polypeptide binding]; other site 485918009478 catalytic residue [active] 485918009479 Right handed beta helix region; Region: Beta_helix; pfam13229 485918009480 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 485918009481 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918009482 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 485918009483 Interdomain contacts; other site 485918009484 Cytokine receptor motif; other site 485918009485 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 485918009486 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 485918009487 active site 485918009488 metal binding site [ion binding]; metal-binding site 485918009489 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 485918009490 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918009491 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918009492 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918009493 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918009494 FecR protein; Region: FecR; pfam04773 485918009495 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918009496 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918009497 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918009498 DNA binding residues [nucleotide binding] 485918009499 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 485918009500 CheW-like domain; Region: CheW; pfam01584 485918009501 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918009502 TPR motif; other site 485918009503 binding surface 485918009504 Leucine rich repeat; Region: LRR_8; pfam13855 485918009505 Leucine rich repeat; Region: LRR_8; pfam13855 485918009506 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 485918009507 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 485918009508 Aspartyl protease; Region: Asp_protease_2; pfam13650 485918009509 catalytic motif [active] 485918009510 Catalytic residue [active] 485918009511 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 485918009512 glycosyltransferase, MGT family; Region: MGT; TIGR01426 485918009513 active site 485918009514 TDP-binding site; other site 485918009515 acceptor substrate-binding pocket; other site 485918009516 homodimer interface [polypeptide binding]; other site 485918009517 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918009518 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918009519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918009520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918009521 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918009522 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 485918009523 E3 interaction surface; other site 485918009524 lipoyl attachment site [posttranslational modification]; other site 485918009525 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918009526 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 485918009527 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 485918009528 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 485918009529 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918009530 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 485918009531 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 485918009532 B12 binding site [chemical binding]; other site 485918009533 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 485918009534 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 485918009535 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 485918009536 Acyltransferase family; Region: Acyl_transf_3; pfam01757 485918009537 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 485918009538 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918009539 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918009540 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918009541 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918009542 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918009543 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918009544 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 485918009545 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 485918009546 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 485918009547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918009548 putative substrate translocation pore; other site 485918009549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918009550 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 485918009551 active site 485918009552 catalytic residues [active] 485918009553 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918009554 TPR motif; other site 485918009555 binding surface 485918009556 Tetratricopeptide repeat; Region: TPR_16; pfam13432 485918009557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918009558 binding surface 485918009559 TPR motif; other site 485918009560 TPR repeat; Region: TPR_11; pfam13414 485918009561 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918009562 binding surface 485918009563 TPR motif; other site 485918009564 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918009565 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918009566 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918009567 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 485918009568 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 485918009569 motif II; other site 485918009570 Domain present in PSD-95, Dlg, and ZO-1/2; Region: PDZ; smart00228 485918009571 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 485918009572 Catalytic dyad [active] 485918009573 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918009574 FecR protein; Region: FecR; pfam04773 485918009575 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918009576 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918009577 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918009578 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918009579 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918009580 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 485918009581 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 485918009582 transcriptional activator RfaH; Region: RfaH; TIGR01955 485918009583 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 485918009584 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 485918009585 active site 485918009586 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918009587 FtsX-like permease family; Region: FtsX; pfam02687 485918009588 FtsX-like permease family; Region: FtsX; pfam02687 485918009589 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 485918009590 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 485918009591 dimerization interface [polypeptide binding]; other site 485918009592 PAS domain; Region: PAS; smart00091 485918009593 putative active site [active] 485918009594 heme pocket [chemical binding]; other site 485918009595 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918009596 dimer interface [polypeptide binding]; other site 485918009597 phosphorylation site [posttranslational modification] 485918009598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918009599 ATP binding site [chemical binding]; other site 485918009600 Mg2+ binding site [ion binding]; other site 485918009601 G-X-G motif; other site 485918009602 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 485918009603 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 485918009604 Ligand Binding Site [chemical binding]; other site 485918009605 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 485918009606 K+-transporting ATPase, c chain; Region: KdpC; cl00944 485918009607 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 485918009608 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 485918009609 Soluble P-type ATPase [General function prediction only]; Region: COG4087 485918009610 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 485918009611 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 485918009612 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 485918009613 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 485918009614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918009615 active site 485918009616 phosphorylation site [posttranslational modification] 485918009617 intermolecular recognition site; other site 485918009618 dimerization interface [polypeptide binding]; other site 485918009619 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918009620 ATP binding site [chemical binding]; other site 485918009621 Walker B motif; other site 485918009622 arginine finger; other site 485918009623 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 485918009624 Cadherin repeat-like domain; Region: CA_like; cl15786 485918009625 Ca2+ binding site [ion binding]; other site 485918009626 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 485918009627 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918009628 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 485918009629 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 485918009630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918009631 TPR motif; other site 485918009632 binding surface 485918009633 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 485918009634 Acyltransferase family; Region: Acyl_transf_3; pfam01757 485918009635 Histidine kinase; Region: His_kinase; pfam06580 485918009636 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918009637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918009638 active site 485918009639 phosphorylation site [posttranslational modification] 485918009640 intermolecular recognition site; other site 485918009641 dimerization interface [polypeptide binding]; other site 485918009642 LytTr DNA-binding domain; Region: LytTR; smart00850 485918009643 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 485918009644 active site 485918009645 catalytic residues [active] 485918009646 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 485918009647 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 485918009648 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 485918009649 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918009650 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918009651 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918009652 DNA binding residues [nucleotide binding] 485918009653 FecR protein; Region: FecR; pfam04773 485918009654 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918009655 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918009656 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918009657 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918009658 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918009659 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 485918009660 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 485918009661 Scramblase; Region: Scramblase; pfam03803 485918009662 CheB methylesterase; Region: CheB_methylest; pfam01339 485918009663 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 485918009664 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 485918009665 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 485918009666 PAS domain; Region: PAS_9; pfam13426 485918009667 PAS fold; Region: PAS_3; pfam08447 485918009668 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918009669 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 485918009670 putative active site [active] 485918009671 heme pocket [chemical binding]; other site 485918009672 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918009673 putative active site [active] 485918009674 heme pocket [chemical binding]; other site 485918009675 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918009676 dimer interface [polypeptide binding]; other site 485918009677 phosphorylation site [posttranslational modification] 485918009678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918009679 ATP binding site [chemical binding]; other site 485918009680 Mg2+ binding site [ion binding]; other site 485918009681 G-X-G motif; other site 485918009682 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 485918009683 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918009684 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918009685 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918009686 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918009687 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918009688 SusD family; Region: SusD; pfam07980 485918009689 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 485918009690 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 485918009691 active site 485918009692 FMN binding site [chemical binding]; other site 485918009693 substrate binding site [chemical binding]; other site 485918009694 putative catalytic residue [active] 485918009695 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918009696 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918009697 ligand binding site [chemical binding]; other site 485918009698 flexible hinge region; other site 485918009699 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 485918009700 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 485918009701 Cytochrome c; Region: Cytochrom_C; pfam00034 485918009702 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 485918009703 MarR family; Region: MarR_2; pfam12802 485918009704 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 485918009705 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918009706 Coenzyme A binding pocket [chemical binding]; other site 485918009707 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 485918009708 Beta/Gamma crystallin; Region: Crystall; cl02528 485918009709 Beta/Gamma crystallin; Region: Crystall; cl02528 485918009710 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918009711 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 485918009712 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 485918009713 putative active site [active] 485918009714 putative metal binding site [ion binding]; other site 485918009715 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 485918009716 NlpC/P60 family; Region: NLPC_P60; pfam00877 485918009717 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 485918009718 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 485918009719 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 485918009720 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 485918009721 RNA/DNA hybrid binding site [nucleotide binding]; other site 485918009722 active site 485918009723 Uncharacterized conserved protein [Function unknown]; Region: COG2353 485918009724 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 485918009725 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 485918009726 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 485918009727 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918009728 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 485918009729 FtsX-like permease family; Region: FtsX; pfam02687 485918009730 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 485918009731 putative lipid binding site [chemical binding]; other site 485918009732 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 485918009733 SmpB-tmRNA interface; other site 485918009734 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 485918009735 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 485918009736 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 485918009737 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 485918009738 active site 485918009739 intersubunit interface [polypeptide binding]; other site 485918009740 zinc binding site [ion binding]; other site 485918009741 Na+ binding site [ion binding]; other site 485918009742 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 485918009743 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 485918009744 intersubunit interface [polypeptide binding]; other site 485918009745 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 485918009746 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 485918009747 dimer interface [polypeptide binding]; other site 485918009748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918009749 catalytic residue [active] 485918009750 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 485918009751 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 485918009752 AAA domain; Region: AAA_26; pfam13500 485918009753 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 485918009754 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 485918009755 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 485918009756 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 485918009757 ribonuclease R; Region: RNase_R; TIGR02063 485918009758 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 485918009759 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 485918009760 RNB domain; Region: RNB; pfam00773 485918009761 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 485918009762 RNA binding site [nucleotide binding]; other site 485918009763 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 485918009764 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 485918009765 substrate binding pocket [chemical binding]; other site 485918009766 chain length determination region; other site 485918009767 substrate-Mg2+ binding site; other site 485918009768 catalytic residues [active] 485918009769 aspartate-rich region 1; other site 485918009770 active site lid residues [active] 485918009771 aspartate-rich region 2; other site 485918009772 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 485918009773 four helix bundle protein; Region: TIGR02436 485918009774 amino acid transporter; Region: 2A0306; TIGR00909 485918009775 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 485918009776 DoxX; Region: DoxX; pfam07681 485918009777 Smr domain; Region: Smr; cl02619 485918009778 Tic20-like protein; Region: Tic20; pfam09685 485918009779 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 485918009780 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 485918009781 active site 485918009782 catalytic residues [active] 485918009783 aldehyde dehydrogenase family 7 member; Region: PLN02315 485918009784 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 485918009785 tetrameric interface [polypeptide binding]; other site 485918009786 NAD binding site [chemical binding]; other site 485918009787 catalytic residues [active] 485918009788 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 485918009789 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 485918009790 active site 485918009791 oligomerization interface [polypeptide binding]; other site 485918009792 metal binding site [ion binding]; metal-binding site 485918009793 exopolyphosphatase; Region: exo_poly_only; TIGR03706 485918009794 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 485918009795 polyphosphate kinase; Provisional; Region: PRK05443 485918009796 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 485918009797 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 485918009798 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 485918009799 domain interface [polypeptide binding]; other site 485918009800 active site 485918009801 catalytic site [active] 485918009802 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 485918009803 domain interface [polypeptide binding]; other site 485918009804 active site 485918009805 catalytic site [active] 485918009806 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 485918009807 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 485918009808 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 485918009809 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 485918009810 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 485918009811 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 485918009812 tetramerization interface [polypeptide binding]; other site 485918009813 active site 485918009814 pantoate--beta-alanine ligase; Region: panC; TIGR00018 485918009815 Pantoate-beta-alanine ligase; Region: PanC; cd00560 485918009816 active site 485918009817 ATP-binding site [chemical binding]; other site 485918009818 pantoate-binding site; other site 485918009819 HXXH motif; other site 485918009820 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 485918009821 S-adenosylmethionine synthetase; Validated; Region: PRK05250 485918009822 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 485918009823 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 485918009824 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 485918009825 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 485918009826 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 485918009827 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 485918009828 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 485918009829 Predicted peptidase [General function prediction only]; Region: COG4099 485918009830 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 485918009831 Outer membrane efflux protein; Region: OEP; pfam02321 485918009832 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 485918009833 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 485918009834 Acyltransferase family; Region: Acyl_transf_3; pfam01757 485918009835 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 485918009836 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 485918009837 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 485918009838 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918009839 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918009840 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 485918009841 Interdomain contacts; other site 485918009842 Cytokine receptor motif; other site 485918009843 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 485918009844 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 485918009845 Interdomain contacts; other site 485918009846 Cytokine receptor motif; other site 485918009847 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 485918009848 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 485918009849 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 485918009850 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 485918009851 Interdomain contacts; other site 485918009852 Cytokine receptor motif; other site 485918009853 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918009854 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 485918009855 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 485918009856 DXD motif; other site 485918009857 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 485918009858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918009859 active site 485918009860 phosphorylation site [posttranslational modification] 485918009861 intermolecular recognition site; other site 485918009862 dimerization interface [polypeptide binding]; other site 485918009863 Bacterial sugar transferase; Region: Bac_transf; pfam02397 485918009864 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 485918009865 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 485918009866 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 485918009867 DXD motif; other site 485918009868 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 485918009869 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 485918009870 Probable Catalytic site; other site 485918009871 metal-binding site 485918009872 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 485918009873 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 485918009874 active site 485918009875 dimer interface [polypeptide binding]; other site 485918009876 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 485918009877 Ligand Binding Site [chemical binding]; other site 485918009878 Molecular Tunnel; other site 485918009879 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 485918009880 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 485918009881 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 485918009882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918009883 S-adenosylmethionine binding site [chemical binding]; other site 485918009884 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 485918009885 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 485918009886 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 485918009887 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918009888 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 485918009889 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 485918009890 trimer interface [polypeptide binding]; other site 485918009891 active site 485918009892 substrate binding site [chemical binding]; other site 485918009893 CoA binding site [chemical binding]; other site 485918009894 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 485918009895 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 485918009896 putative homodimer interface [polypeptide binding]; other site 485918009897 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918009898 Coenzyme A binding pocket [chemical binding]; other site 485918009899 Predicted amidohydrolase [General function prediction only]; Region: COG0388 485918009900 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 485918009901 putative active site [active] 485918009902 catalytic triad [active] 485918009903 putative dimer interface [polypeptide binding]; other site 485918009904 Domain of unknown function DUF77; Region: DUF77; pfam01910 485918009905 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 485918009906 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 485918009907 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 485918009908 GTP-binding protein YchF; Reviewed; Region: PRK09601 485918009909 YchF GTPase; Region: YchF; cd01900 485918009910 G1 box; other site 485918009911 GTP/Mg2+ binding site [chemical binding]; other site 485918009912 Switch I region; other site 485918009913 G2 box; other site 485918009914 Switch II region; other site 485918009915 G3 box; other site 485918009916 G4 box; other site 485918009917 G5 box; other site 485918009918 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 485918009919 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 485918009920 active site 485918009921 substrate binding site [chemical binding]; other site 485918009922 Phosphotransferase enzyme family; Region: APH; pfam01636 485918009923 ATP binding site [chemical binding]; other site 485918009924 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918009925 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918009926 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918009927 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918009928 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918009929 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 485918009930 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918009931 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 485918009932 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918009933 Outer membrane efflux protein; Region: OEP; pfam02321 485918009934 Outer membrane efflux protein; Region: OEP; pfam02321 485918009935 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 485918009936 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 485918009937 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 485918009938 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 485918009939 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 485918009940 homodimer interface [polypeptide binding]; other site 485918009941 substrate-cofactor binding pocket; other site 485918009942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918009943 catalytic residue [active] 485918009944 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918009945 Protein of unknown function (DUF1418); Region: DUF1418; cl11648 485918009946 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 485918009947 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 485918009948 active site residue [active] 485918009949 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918009950 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 485918009951 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 485918009952 dimerization interface [polypeptide binding]; other site 485918009953 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918009954 dimer interface [polypeptide binding]; other site 485918009955 phosphorylation site [posttranslational modification] 485918009956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918009957 ATP binding site [chemical binding]; other site 485918009958 G-X-G motif; other site 485918009959 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 485918009960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918009961 active site 485918009962 phosphorylation site [posttranslational modification] 485918009963 intermolecular recognition site; other site 485918009964 dimerization interface [polypeptide binding]; other site 485918009965 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 485918009966 DNA binding site [nucleotide binding] 485918009967 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 485918009968 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 485918009969 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 485918009970 ABC transporter; Region: ABC_tran_2; pfam12848 485918009971 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 485918009972 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 485918009973 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 485918009974 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 485918009975 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 485918009976 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 485918009977 active site 485918009978 dimer interface [polypeptide binding]; other site 485918009979 motif 1; other site 485918009980 motif 2; other site 485918009981 motif 3; other site 485918009982 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 485918009983 anticodon binding site; other site 485918009984 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 485918009985 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 485918009986 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 485918009987 Response regulator receiver domain; Region: Response_reg; pfam00072 485918009988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918009989 active site 485918009990 phosphorylation site [posttranslational modification] 485918009991 intermolecular recognition site; other site 485918009992 dimerization interface [polypeptide binding]; other site 485918009993 GAF domain; Region: GAF_3; pfam13492 485918009994 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918009995 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918009996 dimer interface [polypeptide binding]; other site 485918009997 phosphorylation site [posttranslational modification] 485918009998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918009999 ATP binding site [chemical binding]; other site 485918010000 Mg2+ binding site [ion binding]; other site 485918010001 G-X-G motif; other site 485918010002 Response regulator receiver domain; Region: Response_reg; pfam00072 485918010003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918010004 active site 485918010005 phosphorylation site [posttranslational modification] 485918010006 intermolecular recognition site; other site 485918010007 dimerization interface [polypeptide binding]; other site 485918010008 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918010009 dimer interface [polypeptide binding]; other site 485918010010 phosphorylation site [posttranslational modification] 485918010011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918010012 ATP binding site [chemical binding]; other site 485918010013 Mg2+ binding site [ion binding]; other site 485918010014 G-X-G motif; other site 485918010015 Domain of unknown function (DUF4302); Region: DUF4302; pfam14135 485918010016 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918010017 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918010018 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918010019 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918010020 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918010021 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 485918010022 Cation efflux family; Region: Cation_efflux; pfam01545 485918010023 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 485918010024 Beta-lactamase; Region: Beta-lactamase; pfam00144 485918010025 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 485918010026 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 485918010027 ligand binding site [chemical binding]; other site 485918010028 NAD binding site [chemical binding]; other site 485918010029 tetramer interface [polypeptide binding]; other site 485918010030 catalytic site [active] 485918010031 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 485918010032 L-serine binding site [chemical binding]; other site 485918010033 ACT domain interface; other site 485918010034 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 485918010035 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 485918010036 Ca binding site [ion binding]; other site 485918010037 ligand binding site I [chemical binding]; other site 485918010038 homodimer interface [polypeptide binding]; other site 485918010039 ligand binding site II [chemical binding]; other site 485918010040 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 485918010041 PKC phosphorylation site [posttranslational modification]; other site 485918010042 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918010043 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 485918010044 23S rRNA binding site [nucleotide binding]; other site 485918010045 L21 binding site [polypeptide binding]; other site 485918010046 L13 binding site [polypeptide binding]; other site 485918010047 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 485918010048 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918010049 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609 485918010050 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 485918010051 Bifunctional nuclease; Region: DNase-RNase; pfam02577 485918010052 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 485918010053 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 485918010054 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 485918010055 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 485918010056 Ligand binding site [chemical binding]; other site 485918010057 Electron transfer flavoprotein domain; Region: ETF; pfam01012 485918010058 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 485918010059 binding surface 485918010060 TPR motif; other site 485918010061 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 485918010062 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 485918010063 Ligand Binding Site [chemical binding]; other site 485918010064 TilS substrate C-terminal domain; Region: TilS_C; smart00977 485918010065 Response regulator receiver domain; Region: Response_reg; pfam00072 485918010066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918010067 active site 485918010068 phosphorylation site [posttranslational modification] 485918010069 intermolecular recognition site; other site 485918010070 dimerization interface [polypeptide binding]; other site 485918010071 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918010072 PAS domain; Region: PAS_9; pfam13426 485918010073 putative active site [active] 485918010074 heme pocket [chemical binding]; other site 485918010075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918010076 dimer interface [polypeptide binding]; other site 485918010077 phosphorylation site [posttranslational modification] 485918010078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918010079 ATP binding site [chemical binding]; other site 485918010080 Mg2+ binding site [ion binding]; other site 485918010081 G-X-G motif; other site 485918010082 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 485918010083 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 485918010084 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 485918010085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918010086 ATP binding site [chemical binding]; other site 485918010087 Mg2+ binding site [ion binding]; other site 485918010088 G-X-G motif; other site 485918010089 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 485918010090 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 485918010091 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 485918010092 Rhomboid family; Region: Rhomboid; cl11446 485918010093 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 485918010094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918010095 NADH(P)-binding; Region: NAD_binding_10; pfam13460 485918010096 NAD(P) binding site [chemical binding]; other site 485918010097 active site 485918010098 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 485918010099 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 485918010100 active site 485918010101 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918010102 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 485918010103 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 485918010104 conserved cys residue [active] 485918010105 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 485918010106 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 485918010107 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 485918010108 Low-spin heme binding site [chemical binding]; other site 485918010109 D-pathway; other site 485918010110 Putative water exit pathway; other site 485918010111 Binuclear center (active site) [active] 485918010112 K-pathway; other site 485918010113 Putative proton exit pathway; other site 485918010114 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 485918010115 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 485918010116 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 485918010117 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 485918010118 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 485918010119 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 485918010120 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918010121 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918010122 Domain of unknown function (DUF303); Region: DUF303; pfam03629 485918010123 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 485918010124 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 485918010125 active site 485918010126 catalytic tetrad [active] 485918010127 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 485918010128 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 485918010129 active site 485918010130 catalytic tetrad [active] 485918010131 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918010132 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918010133 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 485918010134 Histidine kinase; Region: His_kinase; pfam06580 485918010135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 485918010136 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918010137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918010138 active site 485918010139 phosphorylation site [posttranslational modification] 485918010140 intermolecular recognition site; other site 485918010141 dimerization interface [polypeptide binding]; other site 485918010142 LytTr DNA-binding domain; Region: LytTR; smart00850 485918010143 Cupin domain; Region: Cupin_2; pfam07883 485918010144 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 485918010145 aromatic chitin/cellulose binding site residues [chemical binding]; other site 485918010146 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 485918010147 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 485918010148 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 485918010149 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 485918010150 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 485918010151 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 485918010152 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 485918010153 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918010154 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918010155 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918010156 short chain dehydrogenase; Provisional; Region: PRK06180 485918010157 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918010158 NADP binding site [chemical binding]; other site 485918010159 active site 485918010160 steroid binding site; other site 485918010161 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 485918010162 Sulfatase; Region: Sulfatase; pfam00884 485918010163 short chain dehydrogenase; Provisional; Region: PRK06180 485918010164 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918010165 NADP binding site [chemical binding]; other site 485918010166 active site 485918010167 steroid binding site; other site 485918010168 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918010169 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918010170 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918010171 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 485918010172 Glyco_18 domain; Region: Glyco_18; smart00636 485918010173 active site 485918010174 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 485918010175 sugar binding site [chemical binding]; other site 485918010176 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 485918010177 putative metal binding site [ion binding]; other site 485918010178 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 485918010179 sugar binding site [chemical binding]; other site 485918010180 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918010181 FecR protein; Region: FecR; pfam04773 485918010182 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918010183 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918010184 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 485918010185 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918010186 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918010187 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918010188 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918010189 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918010190 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 485918010191 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 485918010192 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 485918010193 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 485918010194 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 485918010195 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 485918010196 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 485918010197 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 485918010198 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 485918010199 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 485918010200 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 485918010201 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 485918010202 4Fe-4S binding domain; Region: Fer4; pfam00037 485918010203 4Fe-4S binding domain; Region: Fer4; pfam00037 485918010204 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 485918010205 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 485918010206 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 485918010207 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 485918010208 catalytic loop [active] 485918010209 iron binding site [ion binding]; other site 485918010210 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 485918010211 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 485918010212 [4Fe-4S] binding site [ion binding]; other site 485918010213 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 485918010214 molybdopterin cofactor binding site; other site 485918010215 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 485918010216 SLBB domain; Region: SLBB; pfam10531 485918010217 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 485918010218 NADH dehydrogenase subunit E; Validated; Region: PRK07539 485918010219 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 485918010220 putative dimer interface [polypeptide binding]; other site 485918010221 [2Fe-2S] cluster binding site [ion binding]; other site 485918010222 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 485918010223 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 485918010224 NADH dehydrogenase subunit D; Validated; Region: PRK06075 485918010225 NADH dehydrogenase subunit B; Validated; Region: PRK06411 485918010226 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 485918010227 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 485918010228 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 485918010229 active site 485918010230 catalytic residues [active] 485918010231 DNA binding site [nucleotide binding] 485918010232 Int/Topo IB signature motif; other site 485918010233 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 485918010234 YopX protein; Region: YopX; pfam09643 485918010235 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 485918010236 ParB-like nuclease domain; Region: ParBc; pfam02195 485918010237 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 485918010238 putative active site [active] 485918010239 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 485918010240 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 485918010241 non-specific DNA binding site [nucleotide binding]; other site 485918010242 salt bridge; other site 485918010243 sequence-specific DNA binding site [nucleotide binding]; other site 485918010244 Helix-turn-helix domain; Region: HTH_39; pfam14090 485918010245 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 485918010246 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 485918010247 ERF superfamily; Region: ERF; pfam04404 485918010248 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 485918010249 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 485918010250 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 485918010251 Disulfide bond isomerase protein N-terminus; Region: DsbC_N; pfam10411 485918010252 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 485918010253 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 485918010254 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 485918010255 non-specific DNA binding site [nucleotide binding]; other site 485918010256 sequence-specific DNA binding site [nucleotide binding]; other site 485918010257 salt bridge; other site 485918010258 coenzyme A disulfide reductase; Provisional; Region: PRK13512 485918010259 Phage terminase large subunit; Region: Terminase_3; cl12054 485918010260 Phage portal protein; Region: Phage_portal; pfam04860 485918010261 Phage-related protein [Function unknown]; Region: COG4695; cl01923 485918010262 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 485918010263 active site 485918010264 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 485918010265 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 485918010266 Phage capsid family; Region: Phage_capsid; pfam05065 485918010267 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 485918010268 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 485918010269 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 485918010270 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 485918010271 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 485918010272 Phage major tail protein 2; Region: Phage_tail_2; cl11463 485918010273 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 485918010274 Phage major tail protein 2; Region: Phage_tail_2; cl11463 485918010275 Phage Tail Collar Domain; Region: Collar; pfam07484 485918010276 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 485918010277 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 485918010278 Predicted peptidase [General function prediction only]; Region: COG4099 485918010279 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 485918010280 active site 485918010281 catalytic triad [active] 485918010282 oxyanion hole [active] 485918010283 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 485918010284 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 485918010285 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 485918010286 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 485918010287 active site 485918010288 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 485918010289 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 485918010290 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 485918010291 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 485918010292 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 485918010293 Phage protein D [General function prediction only]; Region: COG3500 485918010294 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 485918010295 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 485918010296 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 485918010297 Uncharacterized conserved protein [Function unknown]; Region: COG4104 485918010298 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 485918010299 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 485918010300 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918010301 Walker A motif; other site 485918010302 ATP binding site [chemical binding]; other site 485918010303 Walker B motif; other site 485918010304 arginine finger; other site 485918010305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 485918010306 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 485918010307 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 485918010308 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 485918010309 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 485918010310 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 485918010311 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 485918010312 putative active site; other site 485918010313 catalytic triad [active] 485918010314 putative dimer interface [polypeptide binding]; other site 485918010315 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918010316 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918010317 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 485918010318 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918010319 Uncharacterized conserved protein [Function unknown]; Region: COG3391 485918010320 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 485918010321 active site 485918010322 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 485918010323 DNA-binding site [nucleotide binding]; DNA binding site 485918010324 RNA-binding motif; other site 485918010325 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 485918010326 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 485918010327 active site 485918010328 FMN binding site [chemical binding]; other site 485918010329 substrate binding site [chemical binding]; other site 485918010330 homotetramer interface [polypeptide binding]; other site 485918010331 catalytic residue [active] 485918010332 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 485918010333 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 485918010334 putative protofilament interface [polypeptide binding]; other site 485918010335 nucleotide binding site [chemical binding]; other site 485918010336 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 485918010337 substrate binding pocket [chemical binding]; other site 485918010338 substrate-Mg2+ binding site; other site 485918010339 aspartate-rich region 1; other site 485918010340 aspartate-rich region 2; other site 485918010341 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 485918010342 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918010343 phosphorylation site [posttranslational modification] 485918010344 dimer interface [polypeptide binding]; other site 485918010345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918010346 ATP binding site [chemical binding]; other site 485918010347 Mg2+ binding site [ion binding]; other site 485918010348 G-X-G motif; other site 485918010349 Response regulator receiver domain; Region: Response_reg; pfam00072 485918010350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918010351 active site 485918010352 phosphorylation site [posttranslational modification] 485918010353 intermolecular recognition site; other site 485918010354 dimerization interface [polypeptide binding]; other site 485918010355 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 485918010356 Zn binding site [ion binding]; other site 485918010357 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 485918010358 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 485918010359 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 485918010360 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 485918010361 Uncharacterized conserved protein [Function unknown]; Region: COG2128 485918010362 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 485918010363 classical (c) SDRs; Region: SDR_c; cd05233 485918010364 NAD(P) binding site [chemical binding]; other site 485918010365 active site 485918010366 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 485918010367 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 485918010368 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 485918010369 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 485918010370 ligand binding site [chemical binding]; other site 485918010371 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 485918010372 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 485918010373 ligand binding site [chemical binding]; other site 485918010374 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918010375 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918010376 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918010377 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 485918010378 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918010379 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 485918010380 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918010381 dimer interface [polypeptide binding]; other site 485918010382 phosphorylation site [posttranslational modification] 485918010383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918010384 ATP binding site [chemical binding]; other site 485918010385 Mg2+ binding site [ion binding]; other site 485918010386 G-X-G motif; other site 485918010387 Domain of unknown function (DUF4251); Region: DUF4251; pfam14059 485918010388 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 485918010389 Leucine carboxyl methyltransferase; Region: LCM; cl01306 485918010390 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 485918010391 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 485918010392 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 485918010393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918010394 active site 485918010395 phosphorylation site [posttranslational modification] 485918010396 intermolecular recognition site; other site 485918010397 dimerization interface [polypeptide binding]; other site 485918010398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918010399 Walker A motif; other site 485918010400 ATP binding site [chemical binding]; other site 485918010401 Walker B motif; other site 485918010402 arginine finger; other site 485918010403 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 485918010404 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 485918010405 Response regulator receiver domain; Region: Response_reg; pfam00072 485918010406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918010407 active site 485918010408 phosphorylation site [posttranslational modification] 485918010409 intermolecular recognition site; other site 485918010410 dimerization interface [polypeptide binding]; other site 485918010411 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 485918010412 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 485918010413 ATP binding site [chemical binding]; other site 485918010414 Mg++ binding site [ion binding]; other site 485918010415 motif III; other site 485918010416 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 485918010417 nucleotide binding region [chemical binding]; other site 485918010418 ATP-binding site [chemical binding]; other site 485918010419 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 485918010420 Mechanosensitive ion channel; Region: MS_channel; pfam00924 485918010421 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 485918010422 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918010423 dimer interface [polypeptide binding]; other site 485918010424 putative metal binding site [ion binding]; other site 485918010425 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918010426 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 485918010427 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 485918010428 ligand binding site [chemical binding]; other site 485918010429 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 485918010430 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 485918010431 FecR protein; Region: FecR; pfam04773 485918010432 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918010433 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 485918010434 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918010435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918010436 active site 485918010437 phosphorylation site [posttranslational modification] 485918010438 intermolecular recognition site; other site 485918010439 dimerization interface [polypeptide binding]; other site 485918010440 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918010441 DNA binding residues [nucleotide binding] 485918010442 dimerization interface [polypeptide binding]; other site 485918010443 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 485918010444 active site 485918010445 catalytic triad [active] 485918010446 oxyanion hole [active] 485918010447 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 485918010448 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918010449 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 485918010450 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918010451 Outer membrane efflux protein; Region: OEP; pfam02321 485918010452 Outer membrane efflux protein; Region: OEP; pfam02321 485918010453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918010454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918010455 WHG domain; Region: WHG; pfam13305 485918010456 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918010457 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 485918010458 NAD(P) binding site [chemical binding]; other site 485918010459 active site 485918010460 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 485918010461 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 485918010462 homodimer interface [polypeptide binding]; other site 485918010463 substrate-cofactor binding pocket; other site 485918010464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918010465 catalytic residue [active] 485918010466 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 485918010467 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 485918010468 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 485918010469 active site 485918010470 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 485918010471 putative active site [active] 485918010472 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 485918010473 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 485918010474 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 485918010475 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 485918010476 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 485918010477 motif II; other site 485918010478 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 485918010479 nudix motif; other site 485918010480 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 485918010481 ribulokinase; Provisional; Region: PRK04123 485918010482 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 485918010483 N- and C-terminal domain interface [polypeptide binding]; other site 485918010484 active site 485918010485 MgATP binding site [chemical binding]; other site 485918010486 catalytic site [active] 485918010487 metal binding site [ion binding]; metal-binding site 485918010488 carbohydrate binding site [chemical binding]; other site 485918010489 homodimer interface [polypeptide binding]; other site 485918010490 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 485918010491 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 485918010492 intersubunit interface [polypeptide binding]; other site 485918010493 active site 485918010494 Zn2+ binding site [ion binding]; other site 485918010495 L-arabinose isomerase; Provisional; Region: PRK02929 485918010496 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 485918010497 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 485918010498 trimer interface [polypeptide binding]; other site 485918010499 putative substrate binding site [chemical binding]; other site 485918010500 putative metal binding site [ion binding]; other site 485918010501 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 485918010502 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918010503 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 485918010504 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 485918010505 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 485918010506 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 485918010507 Domain of Unknown Function with PDB structure (DUF3858); Region: DUF3858; pfam12970 485918010508 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 485918010509 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 485918010510 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 485918010511 Clp amino terminal domain; Region: Clp_N; pfam02861 485918010512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918010513 Walker A motif; other site 485918010514 ATP binding site [chemical binding]; other site 485918010515 Walker B motif; other site 485918010516 arginine finger; other site 485918010517 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918010518 Walker A motif; other site 485918010519 ATP binding site [chemical binding]; other site 485918010520 Walker B motif; other site 485918010521 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 485918010522 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918010523 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918010524 ligand binding site [chemical binding]; other site 485918010525 flexible hinge region; other site 485918010526 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 485918010527 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 485918010528 nucleoside/Zn binding site; other site 485918010529 dimer interface [polypeptide binding]; other site 485918010530 catalytic motif [active] 485918010531 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918010532 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918010533 dimer interface [polypeptide binding]; other site 485918010534 phosphorylation site [posttranslational modification] 485918010535 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918010536 ATP binding site [chemical binding]; other site 485918010537 Mg2+ binding site [ion binding]; other site 485918010538 G-X-G motif; other site 485918010539 Response regulator receiver domain; Region: Response_reg; pfam00072 485918010540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918010541 active site 485918010542 phosphorylation site [posttranslational modification] 485918010543 intermolecular recognition site; other site 485918010544 dimerization interface [polypeptide binding]; other site 485918010545 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 485918010546 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 485918010547 PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to...; Region: PA_GCPII_like; cd02121 485918010548 apical/protease domain interface [polypeptide binding]; other site 485918010549 substrate binding [chemical binding]; other site 485918010550 dimer interface [polypeptide binding]; other site 485918010551 M28 Zn-peptidase prostate-specific membrane antigen; Region: M28_PSMA_like; cd08022 485918010552 dimer interface [polypeptide binding]; other site 485918010553 Peptidase family M28; Region: Peptidase_M28; pfam04389 485918010554 active site 485918010555 metal binding site [ion binding]; metal-binding site 485918010556 Transferrin receptor-like dimerisation domain; Region: TFR_dimer; pfam04253 485918010557 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918010558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918010559 active site 485918010560 phosphorylation site [posttranslational modification] 485918010561 intermolecular recognition site; other site 485918010562 dimerization interface [polypeptide binding]; other site 485918010563 LytTr DNA-binding domain; Region: LytTR; smart00850 485918010564 Outer membrane efflux protein; Region: OEP; pfam02321 485918010565 Outer membrane efflux protein; Region: OEP; pfam02321 485918010566 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 485918010567 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918010568 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 485918010569 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918010570 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 485918010571 active site 485918010572 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 485918010573 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 485918010574 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 485918010575 putative Cl- selectivity filter; other site 485918010576 putative pore gating glutamate residue; other site 485918010577 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 485918010578 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 485918010579 putative NAD(P) binding site [chemical binding]; other site 485918010580 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 485918010581 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 485918010582 active site 485918010583 catalytic tetrad [active] 485918010584 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 485918010585 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 485918010586 active site 485918010587 homotetramer interface [polypeptide binding]; other site 485918010588 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 485918010589 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 485918010590 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 485918010591 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 485918010592 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 485918010593 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 485918010594 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918010595 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918010596 VIT family; Region: VIT1; pfam01988 485918010597 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 485918010598 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 485918010599 inhibitor-cofactor binding pocket; inhibition site 485918010600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918010601 catalytic residue [active] 485918010602 Acyl CoA binding protein; Region: ACBP; pfam00887 485918010603 acyl-CoA binding pocket [chemical binding]; other site 485918010604 CoA binding site [chemical binding]; other site 485918010605 GTP-binding protein LepA; Provisional; Region: PRK05433 485918010606 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 485918010607 G1 box; other site 485918010608 putative GEF interaction site [polypeptide binding]; other site 485918010609 GTP/Mg2+ binding site [chemical binding]; other site 485918010610 Switch I region; other site 485918010611 G2 box; other site 485918010612 G3 box; other site 485918010613 Switch II region; other site 485918010614 G4 box; other site 485918010615 G5 box; other site 485918010616 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 485918010617 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 485918010618 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 485918010619 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 485918010620 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 485918010621 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 485918010622 hypothetical protein; Reviewed; Region: PRK12497 485918010623 adenylosuccinate lyase; Provisional; Region: PRK09285 485918010624 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 485918010625 tetramer interface [polypeptide binding]; other site 485918010626 active site 485918010627 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 485918010628 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 485918010629 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 485918010630 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 485918010631 Zn binding site [ion binding]; other site 485918010632 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 485918010633 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 485918010634 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918010635 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918010636 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918010637 oxidoreductase; Provisional; Region: PRK06196 485918010638 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 485918010639 putative NAD(P) binding site [chemical binding]; other site 485918010640 active site 485918010641 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 485918010642 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 485918010643 active site 485918010644 HIGH motif; other site 485918010645 dimer interface [polypeptide binding]; other site 485918010646 KMSKS motif; other site 485918010647 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 485918010648 RNA binding surface [nucleotide binding]; other site 485918010649 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 485918010650 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 485918010651 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 485918010652 putative di-iron ligands [ion binding]; other site 485918010653 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 485918010654 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 485918010655 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 485918010656 short chain dehydrogenase; Provisional; Region: PRK07102 485918010657 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 485918010658 NAD(P) binding site [chemical binding]; other site 485918010659 active site 485918010660 FAD binding domain; Region: FAD_binding_4; pfam01565 485918010661 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 485918010662 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 485918010663 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 485918010664 EamA-like transporter family; Region: EamA; pfam00892 485918010665 EamA-like transporter family; Region: EamA; pfam00892 485918010666 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 485918010667 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 485918010668 FeS/SAM binding site; other site 485918010669 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 485918010670 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 485918010671 Active_site [active] 485918010672 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 485918010673 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 485918010674 Protein of unknown function (DUF763); Region: DUF763; pfam05559 485918010675 MgtC family; Region: MgtC; pfam02308 485918010676 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 485918010677 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 485918010678 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 485918010679 Walker A/P-loop; other site 485918010680 ATP binding site [chemical binding]; other site 485918010681 Q-loop/lid; other site 485918010682 ABC transporter signature motif; other site 485918010683 Walker B; other site 485918010684 D-loop; other site 485918010685 H-loop/switch region; other site 485918010686 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 485918010687 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918010688 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 485918010689 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918010690 Family of unknown function (DUF695); Region: DUF695; pfam05117 485918010691 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 485918010692 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 485918010693 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 485918010694 putative molybdopterin cofactor binding site [chemical binding]; other site 485918010695 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 485918010696 putative molybdopterin cofactor binding site; other site 485918010697 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 485918010698 Predicted metalloprotease [General function prediction only]; Region: COG2321 485918010699 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 485918010700 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 485918010701 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918010702 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918010703 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918010704 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918010705 binding surface 485918010706 TPR motif; other site 485918010707 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918010708 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918010709 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918010710 dimer interface [polypeptide binding]; other site 485918010711 phosphorylation site [posttranslational modification] 485918010712 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918010713 ATP binding site [chemical binding]; other site 485918010714 Mg2+ binding site [ion binding]; other site 485918010715 G-X-G motif; other site 485918010716 Rdx family; Region: Rdx; cl01407 485918010717 Surface antigen; Region: Bac_surface_Ag; pfam01103 485918010718 Predicted flavoprotein [General function prediction only]; Region: COG0431 485918010719 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 485918010720 Methyltransferase domain; Region: Methyltransf_31; pfam13847 485918010721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918010722 S-adenosylmethionine binding site [chemical binding]; other site 485918010723 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918010724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918010725 active site 485918010726 phosphorylation site [posttranslational modification] 485918010727 intermolecular recognition site; other site 485918010728 dimerization interface [polypeptide binding]; other site 485918010729 LytTr DNA-binding domain; Region: LytTR; smart00850 485918010730 Histidine kinase; Region: His_kinase; pfam06580 485918010731 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 485918010732 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918010733 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918010734 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918010735 Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903 485918010736 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918010737 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 485918010738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918010739 active site 485918010740 phosphorylation site [posttranslational modification] 485918010741 intermolecular recognition site; other site 485918010742 dimerization interface [polypeptide binding]; other site 485918010743 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 485918010744 DNA binding site [nucleotide binding] 485918010745 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 485918010746 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918010747 dimer interface [polypeptide binding]; other site 485918010748 phosphorylation site [posttranslational modification] 485918010749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918010750 ATP binding site [chemical binding]; other site 485918010751 Mg2+ binding site [ion binding]; other site 485918010752 G-X-G motif; other site 485918010753 Domain of unknown function (DUF386); Region: DUF386; cl01047 485918010754 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 485918010755 Putative catalytic domain of Synechocystis sp. Sll1306 protein and other bacterial homologs; Region: CE4_Sll1306_like; cd10978 485918010756 putative active site [active] 485918010757 putative catalytic site [active] 485918010758 WGR domain of bacterial DNA ligases; Region: WGR_DNA_ligase; cd07998 485918010759 HEAT repeats; Region: HEAT_2; pfam13646 485918010760 SWIM zinc finger; Region: SWIM; pfam04434 485918010761 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 485918010762 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 485918010763 putative active site [active] 485918010764 putative NTP binding site [chemical binding]; other site 485918010765 putative nucleic acid binding site [nucleotide binding]; other site 485918010766 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 485918010767 Cytochrome P450; Region: p450; cl12078 485918010768 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918010769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918010770 dimer interface [polypeptide binding]; other site 485918010771 phosphorylation site [posttranslational modification] 485918010772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918010773 ATP binding site [chemical binding]; other site 485918010774 G-X-G motif; other site 485918010775 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 485918010776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918010777 active site 485918010778 phosphorylation site [posttranslational modification] 485918010779 intermolecular recognition site; other site 485918010780 dimerization interface [polypeptide binding]; other site 485918010781 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 485918010782 substrate binding pocket [chemical binding]; other site 485918010783 substrate-Mg2+ binding site; other site 485918010784 aspartate-rich region 1; other site 485918010785 aspartate-rich region 2; other site 485918010786 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 485918010787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918010788 NAD(P) binding site [chemical binding]; other site 485918010789 active site 485918010790 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918010791 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918010792 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 485918010793 Domain of unknown function DUF21; Region: DUF21; pfam01595 485918010794 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 485918010795 Transporter associated domain; Region: CorC_HlyC; smart01091 485918010796 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 485918010797 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 485918010798 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 485918010799 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 485918010800 Peptidase family M23; Region: Peptidase_M23; pfam01551 485918010801 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918010802 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918010803 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 485918010804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918010805 NAD(P) binding site [chemical binding]; other site 485918010806 active site 485918010807 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 485918010808 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 485918010809 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cd00037 485918010810 ligand binding surface [chemical binding]; other site 485918010811 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 485918010812 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 485918010813 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 485918010814 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 485918010815 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 485918010816 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 485918010817 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 485918010818 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 485918010819 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 485918010820 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 485918010821 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 485918010822 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 485918010823 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 485918010824 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 485918010825 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 485918010826 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 485918010827 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 485918010828 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 485918010829 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918010830 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918010831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918010832 active site 485918010833 phosphorylation site [posttranslational modification] 485918010834 intermolecular recognition site; other site 485918010835 dimerization interface [polypeptide binding]; other site 485918010836 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918010837 DNA binding residues [nucleotide binding] 485918010838 dimerization interface [polypeptide binding]; other site 485918010839 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 485918010840 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918010841 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918010842 catalytic residues [active] 485918010843 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 485918010844 Domain of unknown function DUF20; Region: UPF0118; pfam01594 485918010845 shikimate kinase; Reviewed; Region: aroK; PRK00131 485918010846 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 485918010847 ligand-binding site [chemical binding]; other site 485918010848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 485918010849 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918010850 FtsX-like permease family; Region: FtsX; pfam02687 485918010851 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918010852 FtsX-like permease family; Region: FtsX; pfam02687 485918010853 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 485918010854 Predicted periplasmic protein [Function unknown]; Region: COG3698 485918010855 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 485918010856 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 485918010857 active site 485918010858 catalytic residues [active] 485918010859 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 485918010860 GAF domain; Region: GAF; pfam01590 485918010861 Phytochrome region; Region: PHY; pfam00360 485918010862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918010863 ATP binding site [chemical binding]; other site 485918010864 Mg2+ binding site [ion binding]; other site 485918010865 G-X-G motif; other site 485918010866 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 485918010867 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 485918010868 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918010869 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918010870 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918010871 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918010872 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 485918010873 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 485918010874 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 485918010875 FeS/SAM binding site; other site 485918010876 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 485918010877 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 485918010878 Ligand binding site; other site 485918010879 metal-binding site 485918010880 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 485918010881 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 485918010882 XdhC Rossmann domain; Region: XdhC_C; pfam13478 485918010883 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 485918010884 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 485918010885 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 485918010886 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 485918010887 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 485918010888 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 485918010889 catalytic loop [active] 485918010890 iron binding site [ion binding]; other site 485918010891 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 485918010892 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 485918010893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918010894 NAD(P) binding site [chemical binding]; other site 485918010895 active site 485918010896 RHS Repeat; Region: RHS_repeat; pfam05593 485918010897 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 485918010898 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 485918010899 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918010900 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 485918010901 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918010902 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 485918010903 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918010904 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 485918010905 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 485918010906 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 485918010907 putative metal binding site [ion binding]; other site 485918010908 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 485918010909 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 485918010910 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 485918010911 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 485918010912 Protein of unknown function (DUF779); Region: DUF779; pfam05610 485918010913 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 485918010914 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 485918010915 NAD(P) binding site [chemical binding]; other site 485918010916 catalytic residues [active] 485918010917 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 485918010918 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918010919 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918010920 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 485918010921 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 485918010922 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 485918010923 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 485918010924 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 485918010925 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 485918010926 catalytic triad [active] 485918010927 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 485918010928 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 485918010929 Two component regulator propeller; Region: Reg_prop; pfam07494 485918010930 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 485918010931 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 485918010932 Histidine kinase; Region: HisKA_3; pfam07730 485918010933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918010934 ATP binding site [chemical binding]; other site 485918010935 Mg2+ binding site [ion binding]; other site 485918010936 G-X-G motif; other site 485918010937 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918010938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918010939 active site 485918010940 phosphorylation site [posttranslational modification] 485918010941 intermolecular recognition site; other site 485918010942 dimerization interface [polypeptide binding]; other site 485918010943 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918010944 DNA binding residues [nucleotide binding] 485918010945 dimerization interface [polypeptide binding]; other site 485918010946 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 485918010947 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 485918010948 Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576 485918010949 putative ligand binding site [chemical binding]; other site 485918010950 putative catalytic site [active] 485918010951 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 485918010952 PKC phosphorylation site [posttranslational modification]; other site 485918010953 Methyltransferase domain; Region: Methyltransf_31; pfam13847 485918010954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918010955 S-adenosylmethionine binding site [chemical binding]; other site 485918010956 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918010957 DinB family; Region: DinB; cl17821 485918010958 DinB superfamily; Region: DinB_2; pfam12867 485918010959 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 485918010960 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918010961 dimer interface [polypeptide binding]; other site 485918010962 Uncharacterized conserved protein [Function unknown]; Region: COG3379 485918010963 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 485918010964 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 485918010965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 485918010966 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 485918010967 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 485918010968 ATP binding site [chemical binding]; other site 485918010969 putative Mg++ binding site [ion binding]; other site 485918010970 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 485918010971 nucleotide binding region [chemical binding]; other site 485918010972 ATP-binding site [chemical binding]; other site 485918010973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 485918010974 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918010975 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918010976 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918010977 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918010978 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918010979 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918010980 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918010981 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918010982 FecR protein; Region: FecR; pfam04773 485918010983 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918010984 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918010985 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918010986 DNA binding residues [nucleotide binding] 485918010987 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 485918010988 hypothetical protein; Provisional; Region: PRK06489 485918010989 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 485918010990 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 485918010991 trimer interface [polypeptide binding]; other site 485918010992 putative Zn binding site [ion binding]; other site 485918010993 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 485918010994 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 485918010995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918010996 putative substrate translocation pore; other site 485918010997 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 485918010998 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 485918010999 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918011000 Coenzyme A binding pocket [chemical binding]; other site 485918011001 Methyltransferase domain; Region: Methyltransf_31; pfam13847 485918011002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918011003 S-adenosylmethionine binding site [chemical binding]; other site 485918011004 EamA-like transporter family; Region: EamA; cl17759 485918011005 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 485918011006 EamA-like transporter family; Region: EamA; pfam00892 485918011007 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 485918011008 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 485918011009 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 485918011010 putative DNA binding site [nucleotide binding]; other site 485918011011 putative Zn2+ binding site [ion binding]; other site 485918011012 AsnC family; Region: AsnC_trans_reg; pfam01037 485918011013 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918011014 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918011015 ligand binding site [chemical binding]; other site 485918011016 flexible hinge region; other site 485918011017 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 485918011018 FG-GAP repeat; Region: FG-GAP; cl15299 485918011019 Family description; Region: VCBS; pfam13517 485918011020 Family description; Region: VCBS; pfam13517 485918011021 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 485918011022 Family description; Region: VCBS; pfam13517 485918011023 FG-GAP repeat; Region: FG-GAP; cl15299 485918011024 Family description; Region: VCBS; pfam13517 485918011025 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 485918011026 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918011027 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 485918011028 Family description; Region: VCBS; pfam13517 485918011029 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 485918011030 Family description; Region: VCBS; pfam13517 485918011031 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 485918011032 Family description; Region: VCBS; pfam13517 485918011033 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 485918011034 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918011035 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 485918011036 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 485918011037 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918011038 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918011039 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 485918011040 active site 485918011041 metal binding site [ion binding]; metal-binding site 485918011042 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 485918011043 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 485918011044 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918011045 Walker A/P-loop; other site 485918011046 ATP binding site [chemical binding]; other site 485918011047 Q-loop/lid; other site 485918011048 ABC transporter signature motif; other site 485918011049 Walker B; other site 485918011050 D-loop; other site 485918011051 H-loop/switch region; other site 485918011052 LytTr DNA-binding domain; Region: LytTR; smart00850 485918011053 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 485918011054 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 485918011055 catalytic residues [active] 485918011056 catalytic nucleophile [active] 485918011057 Recombinase; Region: Recombinase; pfam07508 485918011058 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 485918011059 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918011060 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 485918011061 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 485918011062 non-specific DNA binding site [nucleotide binding]; other site 485918011063 salt bridge; other site 485918011064 sequence-specific DNA binding site [nucleotide binding]; other site 485918011065 Transposase; Region: HTH_Tnp_1; pfam01527 485918011066 HTH-like domain; Region: HTH_21; pfam13276 485918011067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 485918011068 Integrase core domain; Region: rve; pfam00665 485918011069 Integrase core domain; Region: rve_3; pfam13683 485918011070 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 485918011071 putative active site [active] 485918011072 putative NTP binding site [chemical binding]; other site 485918011073 putative nucleic acid binding site [nucleotide binding]; other site 485918011074 Transposase; Region: HTH_Tnp_1; pfam01527 485918011075 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 485918011076 putative transposase OrfB; Reviewed; Region: PHA02517 485918011077 HTH-like domain; Region: HTH_21; pfam13276 485918011078 Integrase core domain; Region: rve; pfam00665 485918011079 Integrase core domain; Region: rve_3; pfam13683 485918011080 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 485918011081 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 485918011082 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 485918011083 putative active site [active] 485918011084 putative metal-binding site [ion binding]; other site 485918011085 Part of AAA domain; Region: AAA_19; pfam13245 485918011086 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 485918011087 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 485918011088 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 485918011089 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 485918011090 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 485918011091 Family description; Region: VCBS; pfam13517 485918011092 Family description; Region: VCBS; pfam13517 485918011093 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918011094 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 485918011095 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 485918011096 active site 485918011097 Methyltransferase domain; Region: Methyltransf_31; pfam13847 485918011098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918011099 S-adenosylmethionine binding site [chemical binding]; other site 485918011100 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 485918011101 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918011102 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918011103 ligand binding site [chemical binding]; other site 485918011104 flexible hinge region; other site 485918011105 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 485918011106 putative switch regulator; other site 485918011107 non-specific DNA interactions [nucleotide binding]; other site 485918011108 DNA binding site [nucleotide binding] 485918011109 sequence specific DNA binding site [nucleotide binding]; other site 485918011110 putative cAMP binding site [chemical binding]; other site 485918011111 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918011112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918011113 binding surface 485918011114 TPR motif; other site 485918011115 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918011116 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 485918011117 Histidine kinase; Region: HisKA_2; pfam07568 485918011118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918011119 ATP binding site [chemical binding]; other site 485918011120 Mg2+ binding site [ion binding]; other site 485918011121 G-X-G motif; other site 485918011122 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918011123 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918011124 short chain dehydrogenase; Provisional; Region: PRK06523 485918011125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918011126 NAD(P) binding site [chemical binding]; other site 485918011127 active site 485918011128 SnoaL-like domain; Region: SnoaL_2; pfam12680 485918011129 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 485918011130 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 485918011131 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 485918011132 Putative esterase; Region: Esterase; pfam00756 485918011133 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 485918011134 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 485918011135 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 485918011136 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 485918011137 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918011138 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918011139 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 485918011140 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 485918011141 NADP binding site [chemical binding]; other site 485918011142 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 485918011143 Uncharacterized conserved protein [Function unknown]; Region: COG1262 485918011144 lipid A phosphoethanolamine transferase; Reviewed; Region: PRK09598 485918011145 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 485918011146 Sulfatase; Region: Sulfatase; pfam00884 485918011147 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 485918011148 hypothetical protein; Validated; Region: PRK05868 485918011149 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918011150 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918011151 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 485918011152 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918011153 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918011154 ligand binding site [chemical binding]; other site 485918011155 flexible hinge region; other site 485918011156 hypothetical protein; Provisional; Region: PRK07236 485918011157 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 485918011158 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 485918011159 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 485918011160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918011161 putative substrate translocation pore; other site 485918011162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 485918011163 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 485918011164 short chain dehydrogenase; Provisional; Region: PRK06500 485918011165 classical (c) SDRs; Region: SDR_c; cd05233 485918011166 NAD(P) binding site [chemical binding]; other site 485918011167 active site 485918011168 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918011169 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918011170 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918011171 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918011172 ligand binding site [chemical binding]; other site 485918011173 flexible hinge region; other site 485918011174 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 485918011175 Amidase; Region: Amidase; pfam01425 485918011176 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 485918011177 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 485918011178 FMN binding site [chemical binding]; other site 485918011179 active site 485918011180 substrate binding site [chemical binding]; other site 485918011181 catalytic residue [active] 485918011182 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918011183 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918011184 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 485918011185 SdiA-regulated; Region: SdiA-regulated; cd09971 485918011186 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 485918011187 FOG: WD40 repeat [General function prediction only]; Region: COG2319 485918011188 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 485918011189 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 485918011190 Cupin domain; Region: Cupin_2; pfam07883 485918011191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918011192 S-adenosylmethionine binding site [chemical binding]; other site 485918011193 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 485918011194 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918011195 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918011196 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 485918011197 binding surface 485918011198 TPR motif; other site 485918011199 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 485918011200 Histidine kinase; Region: HisKA_3; pfam07730 485918011201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918011202 ATP binding site [chemical binding]; other site 485918011203 Mg2+ binding site [ion binding]; other site 485918011204 G-X-G motif; other site 485918011205 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918011206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918011207 active site 485918011208 phosphorylation site [posttranslational modification] 485918011209 intermolecular recognition site; other site 485918011210 dimerization interface [polypeptide binding]; other site 485918011211 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918011212 DNA binding residues [nucleotide binding] 485918011213 dimerization interface [polypeptide binding]; other site 485918011214 MarR family; Region: MarR; pfam01047 485918011215 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918011216 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 485918011217 active site 485918011218 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918011219 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918011220 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 485918011221 dimer interface [polypeptide binding]; other site 485918011222 FMN binding site [chemical binding]; other site 485918011223 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 485918011224 Ion transport protein; Region: Ion_trans; pfam00520 485918011225 Ion channel; Region: Ion_trans_2; pfam07885 485918011226 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918011227 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918011228 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 485918011229 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918011230 nucleophilic elbow; other site 485918011231 catalytic triad; other site 485918011232 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 485918011233 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 485918011234 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918011235 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 485918011236 Histidine kinase; Region: HisKA_3; pfam07730 485918011237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918011238 ATP binding site [chemical binding]; other site 485918011239 Mg2+ binding site [ion binding]; other site 485918011240 G-X-G motif; other site 485918011241 Clostripain family; Region: Peptidase_C11; pfam03415 485918011242 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918011243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918011244 active site 485918011245 phosphorylation site [posttranslational modification] 485918011246 intermolecular recognition site; other site 485918011247 dimerization interface [polypeptide binding]; other site 485918011248 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918011249 DNA binding residues [nucleotide binding] 485918011250 dimerization interface [polypeptide binding]; other site 485918011251 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 485918011252 active site 485918011253 RibD C-terminal domain; Region: RibD_C; cl17279 485918011254 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 485918011255 AAA domain; Region: AAA_28; pfam13521 485918011256 AAA domain; Region: AAA_14; pfam13173 485918011257 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 485918011258 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918011259 NAD(P) binding site [chemical binding]; other site 485918011260 active site 485918011261 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918011262 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918011263 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 485918011264 Active site serine [active] 485918011265 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 485918011266 A new structural DNA glycosylase; Region: AlkD_like; cd06561 485918011267 active site 485918011268 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 485918011269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918011270 active site 485918011271 phosphorylation site [posttranslational modification] 485918011272 intermolecular recognition site; other site 485918011273 dimerization interface [polypeptide binding]; other site 485918011274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918011275 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 485918011276 Walker A motif; other site 485918011277 ATP binding site [chemical binding]; other site 485918011278 Walker B motif; other site 485918011279 arginine finger; other site 485918011280 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918011281 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918011282 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 485918011283 Histidine kinase; Region: HisKA_2; pfam07568 485918011284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918011285 ATP binding site [chemical binding]; other site 485918011286 Mg2+ binding site [ion binding]; other site 485918011287 G-X-G motif; other site 485918011288 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918011289 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918011290 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 485918011291 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 485918011292 NADP binding site [chemical binding]; other site 485918011293 putative substrate binding site [chemical binding]; other site 485918011294 active site 485918011295 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918011296 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918011297 ligand binding site [chemical binding]; other site 485918011298 flexible hinge region; other site 485918011299 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 485918011300 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918011301 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918011302 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 485918011303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918011304 NAD(P) binding site [chemical binding]; other site 485918011305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918011306 active site 485918011307 active site 485918011308 short chain dehydrogenase; Provisional; Region: PRK06523 485918011309 classical (c) SDRs; Region: SDR_c; cd05233 485918011310 NAD(P) binding site [chemical binding]; other site 485918011311 active site 485918011312 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918011313 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918011314 short chain dehydrogenase; Provisional; Region: PRK06914 485918011315 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918011316 NADP binding site [chemical binding]; other site 485918011317 active site 485918011318 steroid binding site; other site 485918011319 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 485918011320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918011321 NAD(P) binding site [chemical binding]; other site 485918011322 active site 485918011323 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 485918011324 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918011325 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918011326 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918011327 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918011328 catalytic residues [active] 485918011329 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918011330 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918011331 ligand binding site [chemical binding]; other site 485918011332 flexible hinge region; other site 485918011333 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 485918011334 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 485918011335 putative NAD(P) binding site [chemical binding]; other site 485918011336 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 485918011337 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918011338 NAD(P) binding site [chemical binding]; other site 485918011339 active site 485918011340 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918011341 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918011342 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918011343 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918011344 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918011345 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 485918011346 Beta/Gamma crystallin; Region: Crystall; cl02528 485918011347 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 485918011348 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 485918011349 putative sugar binding sites [chemical binding]; other site 485918011350 Q-X-W motif; other site 485918011351 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 485918011352 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918011353 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 485918011354 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 485918011355 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 485918011356 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 485918011357 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 485918011358 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 485918011359 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 485918011360 catalytic loop [active] 485918011361 iron binding site [ion binding]; other site 485918011362 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 485918011363 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 485918011364 Fatty acid desaturase; Region: FA_desaturase; pfam00487 485918011365 Di-iron ligands [ion binding]; other site 485918011366 Response regulator receiver domain; Region: Response_reg; pfam00072 485918011367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918011368 active site 485918011369 phosphorylation site [posttranslational modification] 485918011370 intermolecular recognition site; other site 485918011371 dimerization interface [polypeptide binding]; other site 485918011372 PAS domain; Region: PAS; smart00091 485918011373 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 485918011374 putative active site [active] 485918011375 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918011376 dimer interface [polypeptide binding]; other site 485918011377 phosphorylation site [posttranslational modification] 485918011378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918011379 ATP binding site [chemical binding]; other site 485918011380 Mg2+ binding site [ion binding]; other site 485918011381 G-X-G motif; other site 485918011382 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 485918011383 tetramer interface [polypeptide binding]; other site 485918011384 dimer interface [polypeptide binding]; other site 485918011385 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 485918011386 tetramer interface [polypeptide binding]; other site 485918011387 dimer interface [polypeptide binding]; other site 485918011388 circadian clock protein KaiC; Reviewed; Region: PRK09302 485918011389 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 485918011390 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 485918011391 Walker A motif; other site 485918011392 Walker A motif; other site 485918011393 ATP binding site [chemical binding]; other site 485918011394 Walker B motif; other site 485918011395 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 485918011396 Walker A motif; other site 485918011397 ATP binding site [chemical binding]; other site 485918011398 Walker B motif; other site 485918011399 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 485918011400 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 485918011401 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918011402 putative metal binding site [ion binding]; other site 485918011403 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 485918011404 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918011405 NAD(P) binding site [chemical binding]; other site 485918011406 active site 485918011407 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918011408 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918011409 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 485918011410 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 485918011411 FMN binding site [chemical binding]; other site 485918011412 active site 485918011413 substrate binding site [chemical binding]; other site 485918011414 catalytic residue [active] 485918011415 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 485918011416 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 485918011417 putative NAD(P) binding site [chemical binding]; other site 485918011418 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 485918011419 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918011420 binding surface 485918011421 Tetratricopeptide repeat; Region: TPR_16; pfam13432 485918011422 TPR motif; other site 485918011423 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918011424 binding surface 485918011425 TPR motif; other site 485918011426 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918011427 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 485918011428 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 485918011429 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 485918011430 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 485918011431 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 485918011432 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 485918011433 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257 485918011434 PKC phosphorylation site [posttranslational modification]; other site 485918011435 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 485918011436 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 485918011437 IncA protein; Region: IncA; pfam04156 485918011438 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 485918011439 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 485918011440 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 485918011441 Domain of unknown function (DUF336); Region: DUF336; pfam03928 485918011442 short chain dehydrogenase; Provisional; Region: PRK09291 485918011443 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918011444 NAD(P) binding site [chemical binding]; other site 485918011445 active site 485918011446 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 485918011447 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918011448 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 485918011449 Histidine kinase; Region: HisKA_2; pfam07568 485918011450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918011451 ATP binding site [chemical binding]; other site 485918011452 Mg2+ binding site [ion binding]; other site 485918011453 G-X-G motif; other site 485918011454 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 485918011455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918011456 active site 485918011457 phosphorylation site [posttranslational modification] 485918011458 intermolecular recognition site; other site 485918011459 dimerization interface [polypeptide binding]; other site 485918011460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918011461 Walker A motif; other site 485918011462 ATP binding site [chemical binding]; other site 485918011463 Walker B motif; other site 485918011464 arginine finger; other site 485918011465 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 485918011466 Pirin-related protein [General function prediction only]; Region: COG1741 485918011467 Pirin; Region: Pirin; pfam02678 485918011468 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 485918011469 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918011470 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918011471 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918011472 FtsX-like permease family; Region: FtsX; pfam02687 485918011473 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918011474 FtsX-like permease family; Region: FtsX; pfam02687 485918011475 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 485918011476 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918011477 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918011478 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918011479 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918011480 FecR protein; Region: FecR; pfam04773 485918011481 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918011482 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918011483 DNA binding residues [nucleotide binding] 485918011484 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918011485 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918011486 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 485918011487 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918011488 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918011489 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 485918011490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918011491 NAD(P) binding site [chemical binding]; other site 485918011492 active site 485918011493 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 485918011494 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 485918011495 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918011496 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918011497 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918011498 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 485918011499 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 485918011500 Right handed beta helix region; Region: Beta_helix; pfam13229 485918011501 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918011502 FOG: PKD repeat [General function prediction only]; Region: COG3291 485918011503 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918011504 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918011505 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918011506 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918011507 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918011508 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918011509 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918011510 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918011511 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918011512 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918011513 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 485918011514 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cd02257 485918011515 Ubiquitin carboxyl-terminal hydrolase; Region: UCH; pfam00443 485918011516 active site 485918011517 Trehalose utilisation; Region: ThuA; pfam06283 485918011518 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 485918011519 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918011520 Cytochrome c; Region: Cytochrom_C; cl11414 485918011521 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 485918011522 ligand binding site [chemical binding]; other site 485918011523 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 485918011524 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 485918011525 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 485918011526 active site 485918011527 catalytic triad [active] 485918011528 oxyanion hole [active] 485918011529 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918011530 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 485918011531 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 485918011532 active site 485918011533 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 485918011534 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 485918011535 Cupin domain; Region: Cupin_2; pfam07883 485918011536 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 485918011537 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 485918011538 Walker A/P-loop; other site 485918011539 ATP binding site [chemical binding]; other site 485918011540 Q-loop/lid; other site 485918011541 ABC transporter signature motif; other site 485918011542 Walker B; other site 485918011543 D-loop; other site 485918011544 H-loop/switch region; other site 485918011545 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 485918011546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 485918011547 dimer interface [polypeptide binding]; other site 485918011548 conserved gate region; other site 485918011549 putative PBP binding loops; other site 485918011550 ABC-ATPase subunit interface; other site 485918011551 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 485918011552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 485918011553 dimer interface [polypeptide binding]; other site 485918011554 conserved gate region; other site 485918011555 putative PBP binding loops; other site 485918011556 ABC-ATPase subunit interface; other site 485918011557 PBP superfamily domain; Region: PBP_like_2; cl17296 485918011558 FOG: PKD repeat [General function prediction only]; Region: COG3291 485918011559 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918011560 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918011561 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918011562 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918011563 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918011564 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918011565 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918011566 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918011567 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918011568 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918011569 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918011570 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 485918011571 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 485918011572 N-terminal plug; other site 485918011573 ligand-binding site [chemical binding]; other site 485918011574 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918011575 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918011576 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918011577 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918011578 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918011579 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918011580 SusD family; Region: SusD; pfam07980 485918011581 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 485918011582 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 485918011583 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 485918011584 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 485918011585 PAS fold; Region: PAS_4; pfam08448 485918011586 PAS fold; Region: PAS_3; pfam08447 485918011587 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918011588 putative active site [active] 485918011589 heme pocket [chemical binding]; other site 485918011590 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918011591 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 485918011592 putative active site [active] 485918011593 heme pocket [chemical binding]; other site 485918011594 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918011595 putative active site [active] 485918011596 heme pocket [chemical binding]; other site 485918011597 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918011598 dimer interface [polypeptide binding]; other site 485918011599 phosphorylation site [posttranslational modification] 485918011600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918011601 ATP binding site [chemical binding]; other site 485918011602 Mg2+ binding site [ion binding]; other site 485918011603 G-X-G motif; other site 485918011604 CheB methylesterase; Region: CheB_methylest; pfam01339 485918011605 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 485918011606 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 485918011607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918011608 S-adenosylmethionine binding site [chemical binding]; other site 485918011609 PAS domain; Region: PAS_9; pfam13426 485918011610 polyubiquitin binding domain of NEMO and related proteins; Region: UBAN; cd09803 485918011611 dimer interface [polypeptide binding]; other site 485918011612 polyubiquitin binding site [polypeptide binding]; other site 485918011613 PAS domain; Region: PAS_10; pfam13596 485918011614 GAF domain; Region: GAF; pfam01590 485918011615 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 485918011616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918011617 dimer interface [polypeptide binding]; other site 485918011618 phosphorylation site [posttranslational modification] 485918011619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918011620 ATP binding site [chemical binding]; other site 485918011621 Mg2+ binding site [ion binding]; other site 485918011622 G-X-G motif; other site 485918011623 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 485918011624 CheB methylesterase; Region: CheB_methylest; pfam01339 485918011625 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 485918011626 Response regulator receiver domain; Region: Response_reg; pfam00072 485918011627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918011628 active site 485918011629 phosphorylation site [posttranslational modification] 485918011630 intermolecular recognition site; other site 485918011631 dimerization interface [polypeptide binding]; other site 485918011632 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 485918011633 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 485918011634 Methyltransferase domain; Region: Methyltransf_11; pfam08241 485918011635 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 485918011636 DoxX-like family; Region: DoxX_3; pfam13781 485918011637 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 485918011638 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918011639 Coenzyme A binding pocket [chemical binding]; other site 485918011640 Protein of unknown function DUF72; Region: DUF72; pfam01904 485918011641 Transcriptional regulator [Transcription]; Region: LysR; COG0583 485918011642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 485918011643 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 485918011644 dimerization interface [polypeptide binding]; other site 485918011645 Major Facilitator Superfamily; Region: MFS_1; pfam07690 485918011646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918011647 putative substrate translocation pore; other site 485918011648 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 485918011649 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918011650 Coenzyme A binding pocket [chemical binding]; other site 485918011651 DEAD-like helicases superfamily; Region: DEXDc; smart00487 485918011652 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 485918011653 ATP binding site [chemical binding]; other site 485918011654 putative Mg++ binding site [ion binding]; other site 485918011655 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 485918011656 nucleotide binding region [chemical binding]; other site 485918011657 ATP-binding site [chemical binding]; other site 485918011658 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 485918011659 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 485918011660 NAD binding site [chemical binding]; other site 485918011661 catalytic Zn binding site [ion binding]; other site 485918011662 structural Zn binding site [ion binding]; other site 485918011663 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 485918011664 YCII-related domain; Region: YCII; cl00999 485918011665 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 485918011666 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 485918011667 putative active site [active] 485918011668 metal binding site [ion binding]; metal-binding site 485918011669 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 485918011670 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 485918011671 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 485918011672 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 485918011673 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 485918011674 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 485918011675 putative NAD(P) binding site [chemical binding]; other site 485918011676 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 485918011677 SnoaL-like domain; Region: SnoaL_3; pfam13474 485918011678 EamA-like transporter family; Region: EamA; pfam00892 485918011679 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 485918011680 putative deacylase active site [active] 485918011681 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 485918011682 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 485918011683 Sulfate transporter family; Region: Sulfate_transp; pfam00916 485918011684 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 485918011685 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918011686 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918011687 ligand binding site [chemical binding]; other site 485918011688 flexible hinge region; other site 485918011689 DinB family; Region: DinB; cl17821 485918011690 DinB superfamily; Region: DinB_2; pfam12867 485918011691 cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662 485918011692 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 485918011693 NADP binding site [chemical binding]; other site 485918011694 putative substrate binding site [chemical binding]; other site 485918011695 active site 485918011696 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918011697 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 485918011698 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 485918011699 Cupin domain; Region: Cupin_2; cl17218 485918011700 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918011701 oxidoreductase; Provisional; Region: PRK06196 485918011702 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 485918011703 putative NAD(P) binding site [chemical binding]; other site 485918011704 active site 485918011705 Protein of unknown function DUF16; Region: DUF16; pfam01519 485918011706 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 485918011707 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 485918011708 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 485918011709 catalytic triad [active] 485918011710 cobyric acid synthase; Provisional; Region: PRK00784 485918011711 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 485918011712 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 485918011713 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 485918011714 catalytic triad [active] 485918011715 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 485918011716 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 485918011717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918011718 homodimer interface [polypeptide binding]; other site 485918011719 catalytic residue [active] 485918011720 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 485918011721 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 485918011722 dimer interface [polypeptide binding]; other site 485918011723 [2Fe-2S] cluster binding site [ion binding]; other site 485918011724 High-affinity nickel-transport protein; Region: NicO; cl00964 485918011725 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 485918011726 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 485918011727 putative NAD(P) binding site [chemical binding]; other site 485918011728 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 485918011729 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 485918011730 putative active site [active] 485918011731 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 485918011732 putative active site [active] 485918011733 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 485918011734 active site 485918011735 SAM binding site [chemical binding]; other site 485918011736 homodimer interface [polypeptide binding]; other site 485918011737 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 485918011738 active site 485918011739 SAM binding site [chemical binding]; other site 485918011740 homodimer interface [polypeptide binding]; other site 485918011741 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 485918011742 Precorrin-8X methylmutase; Region: CbiC; pfam02570 485918011743 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 485918011744 active site 485918011745 putative homodimer interface [polypeptide binding]; other site 485918011746 SAM binding site [chemical binding]; other site 485918011747 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 485918011748 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 485918011749 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 485918011750 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 485918011751 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 485918011752 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 485918011753 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 485918011754 active site 485918011755 SAM binding site [chemical binding]; other site 485918011756 homodimer interface [polypeptide binding]; other site 485918011757 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 485918011758 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 485918011759 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 485918011760 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 485918011761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918011762 Walker A motif; other site 485918011763 ATP binding site [chemical binding]; other site 485918011764 Walker B motif; other site 485918011765 arginine finger; other site 485918011766 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 485918011767 metal ion-dependent adhesion site (MIDAS); other site 485918011768 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 485918011769 homotrimer interface [polypeptide binding]; other site 485918011770 Walker A motif; other site 485918011771 GTP binding site [chemical binding]; other site 485918011772 Walker B motif; other site 485918011773 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 485918011774 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 485918011775 putative dimer interface [polypeptide binding]; other site 485918011776 active site pocket [active] 485918011777 putative cataytic base [active] 485918011778 cobalamin synthase; Reviewed; Region: cobS; PRK00235 485918011779 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 485918011780 catalytic core [active] 485918011781 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 485918011782 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 485918011783 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 485918011784 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 485918011785 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 485918011786 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 485918011787 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 485918011788 Ferritin-like; Region: Ferritin-like; pfam12902 485918011789 Radical SAM superfamily; Region: Radical_SAM; pfam04055 485918011790 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 485918011791 FeS/SAM binding site; other site 485918011792 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 485918011793 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 485918011794 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 485918011795 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 485918011796 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918011797 FtsX-like permease family; Region: FtsX; pfam02687 485918011798 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918011799 FtsX-like permease family; Region: FtsX; pfam02687 485918011800 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 485918011801 active site 485918011802 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918011803 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918011804 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918011805 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918011806 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918011807 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918011808 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918011809 FecR protein; Region: FecR; pfam04773 485918011810 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918011811 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918011812 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918011813 DNA binding residues [nucleotide binding] 485918011814 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 485918011815 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 485918011816 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 485918011817 substrate binding site [chemical binding]; other site 485918011818 active site 485918011819 Protein of unknown function (DUF3823); Region: DUF3823; pfam12866 485918011820 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918011821 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918011822 SusD family; Region: SusD; pfam07980 485918011823 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918011824 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918011825 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918011826 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918011827 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 485918011828 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918011829 Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576 485918011830 putative ligand binding site [chemical binding]; other site 485918011831 putative catalytic site [active] 485918011832 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 485918011833 PKC phosphorylation site [posttranslational modification]; other site 485918011834 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918011835 Beta-lactamase; Region: Beta-lactamase; pfam00144 485918011836 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 485918011837 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918011838 TPR motif; other site 485918011839 Tetratricopeptide repeat; Region: TPR_16; pfam13432 485918011840 binding surface 485918011841 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 485918011842 glycogen binding site [chemical binding]; other site 485918011843 Major royal jelly protein; Region: MRJP; pfam03022 485918011844 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 485918011845 transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330 485918011846 SnoaL-like domain; Region: SnoaL_2; pfam12680 485918011847 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 485918011848 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 485918011849 nucleotide binding site [chemical binding]; other site 485918011850 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918011851 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918011852 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918011853 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918011854 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918011855 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 485918011856 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918011857 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918011858 catalytic residues [active] 485918011859 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 485918011860 Alginate lyase; Region: Alginate_lyase; pfam05426 485918011861 N-terminal domain of PARMER_03128; Region: PARMER_03128_N; cd12106 485918011862 Bacterial proteins similar to Porphyromonas gingivalis HmuY and the C-terminal domain of PARMER_03218; Region: HmuY_like; cd07472 485918011863 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 485918011864 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918011865 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918011866 SusD family; Region: SusD; pfam07980 485918011867 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918011868 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918011869 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918011870 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918011871 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918011872 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 485918011873 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 485918011874 active site 485918011875 catalytic tetrad [active] 485918011876 Carboxylesterase family; Region: COesterase; pfam00135 485918011877 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 485918011878 substrate binding pocket [chemical binding]; other site 485918011879 catalytic triad [active] 485918011880 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918011881 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918011882 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918011883 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918011884 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 485918011885 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 485918011886 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918011887 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918011888 DNA binding residues [nucleotide binding] 485918011889 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 485918011890 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 485918011891 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 485918011892 catalytic residue [active] 485918011893 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 485918011894 putative active site [active] 485918011895 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918011896 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918011897 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918011898 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918011899 DNA binding residues [nucleotide binding] 485918011900 FecR protein; Region: FecR; pfam04773 485918011901 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918011902 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918011903 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918011904 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918011905 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918011906 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 485918011907 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918011908 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918011909 catalytic residues [active] 485918011910 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918011911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918011912 active site 485918011913 phosphorylation site [posttranslational modification] 485918011914 intermolecular recognition site; other site 485918011915 dimerization interface [polypeptide binding]; other site 485918011916 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918011917 DNA binding residues [nucleotide binding] 485918011918 dimerization interface [polypeptide binding]; other site 485918011919 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 485918011920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918011921 ATP binding site [chemical binding]; other site 485918011922 Mg2+ binding site [ion binding]; other site 485918011923 G-X-G motif; other site 485918011924 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 485918011925 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 485918011926 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 485918011927 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 485918011928 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 485918011929 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918011930 SusD family; Region: SusD; pfam07980 485918011931 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918011932 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918011933 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918011934 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918011935 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 485918011936 Two component regulator propeller; Region: Reg_prop; pfam07494 485918011937 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 485918011938 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918011939 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918011940 dimer interface [polypeptide binding]; other site 485918011941 phosphorylation site [posttranslational modification] 485918011942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918011943 ATP binding site [chemical binding]; other site 485918011944 Mg2+ binding site [ion binding]; other site 485918011945 G-X-G motif; other site 485918011946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918011947 Response regulator receiver domain; Region: Response_reg; pfam00072 485918011948 active site 485918011949 phosphorylation site [posttranslational modification] 485918011950 intermolecular recognition site; other site 485918011951 dimerization interface [polypeptide binding]; other site 485918011952 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918011953 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918011954 Acyltransferase family; Region: Acyl_transf_3; pfam01757 485918011955 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 485918011956 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918011957 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 485918011958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918011959 NAD(P) binding site [chemical binding]; other site 485918011960 active site 485918011961 short chain dehydrogenase; Provisional; Region: PRK06500 485918011962 classical (c) SDRs; Region: SDR_c; cd05233 485918011963 NAD(P) binding site [chemical binding]; other site 485918011964 active site 485918011965 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918011966 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918011967 ligand binding site [chemical binding]; other site 485918011968 flexible hinge region; other site 485918011969 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 485918011970 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918011971 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 485918011972 dimerization interface [polypeptide binding]; other site 485918011973 putative DNA binding site [nucleotide binding]; other site 485918011974 putative Zn2+ binding site [ion binding]; other site 485918011975 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 485918011976 putative hydrophobic ligand binding site [chemical binding]; other site 485918011977 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 485918011978 dimer interface [polypeptide binding]; other site 485918011979 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918011980 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 485918011981 short chain dehydrogenase; Provisional; Region: PRK06180 485918011982 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918011983 NADP binding site [chemical binding]; other site 485918011984 active site 485918011985 steroid binding site; other site 485918011986 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 485918011987 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 485918011988 FMN binding site [chemical binding]; other site 485918011989 substrate binding site [chemical binding]; other site 485918011990 putative catalytic residue [active] 485918011991 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 485918011992 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 485918011993 classical (c) SDRs; Region: SDR_c; cd05233 485918011994 NAD(P) binding site [chemical binding]; other site 485918011995 active site 485918011996 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 485918011997 active site 1 [active] 485918011998 dimer interface [polypeptide binding]; other site 485918011999 hexamer interface [polypeptide binding]; other site 485918012000 active site 2 [active] 485918012001 YceI-like domain; Region: YceI; pfam04264 485918012002 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918012003 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918012004 ligand binding site [chemical binding]; other site 485918012005 flexible hinge region; other site 485918012006 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 485918012007 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 485918012008 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 485918012009 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 485918012010 DNA binding site [nucleotide binding] 485918012011 active site 485918012012 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 485918012013 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 485918012014 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 485918012015 DAK2 domain; Region: Dak2; pfam02734 485918012016 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918012017 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918012018 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918012019 probable cinnamyl alcohol dehydrogenase; Region: PLN02586 485918012020 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 485918012021 putative NAD(P) binding site [chemical binding]; other site 485918012022 putative substrate binding site [chemical binding]; other site 485918012023 catalytic Zn binding site [ion binding]; other site 485918012024 structural Zn binding site [ion binding]; other site 485918012025 dimer interface [polypeptide binding]; other site 485918012026 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 485918012027 tetramer (dimer of dimers) interface [polypeptide binding]; other site 485918012028 active site 485918012029 dimer interface [polypeptide binding]; other site 485918012030 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918012031 Coenzyme A binding pocket [chemical binding]; other site 485918012032 Transcriptional regulators [Transcription]; Region: MarR; COG1846 485918012033 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 485918012034 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 485918012035 putative ligand binding site [chemical binding]; other site 485918012036 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 485918012037 Beta-lactamase; Region: Beta-lactamase; pfam00144 485918012038 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 485918012039 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 485918012040 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 485918012041 Coenzyme A binding pocket [chemical binding]; other site 485918012042 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918012043 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 485918012044 dimerization interface [polypeptide binding]; other site 485918012045 putative DNA binding site [nucleotide binding]; other site 485918012046 putative Zn2+ binding site [ion binding]; other site 485918012047 DoxX-like family; Region: DoxX_2; pfam13564 485918012048 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 485918012049 Sulfatase; Region: Sulfatase; pfam00884 485918012050 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 485918012051 dimer interface [polypeptide binding]; other site 485918012052 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918012053 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 485918012054 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918012055 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918012056 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918012057 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918012058 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918012059 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918012060 ligand binding site [chemical binding]; other site 485918012061 flexible hinge region; other site 485918012062 short chain dehydrogenase; Provisional; Region: PRK06500 485918012063 classical (c) SDRs; Region: SDR_c; cd05233 485918012064 NAD(P) binding site [chemical binding]; other site 485918012065 active site 485918012066 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 485918012067 active site 485918012068 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 485918012069 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 485918012070 active site 485918012071 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918012072 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918012073 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 485918012074 DNA binding residues [nucleotide binding] 485918012075 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918012076 FecR protein; Region: FecR; pfam04773 485918012077 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918012078 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918012079 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918012080 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918012081 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918012082 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918012083 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918012084 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 485918012085 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918012086 DoxX-like family; Region: DoxX_2; pfam13564 485918012087 short chain dehydrogenase; Provisional; Region: PRK06500 485918012088 classical (c) SDRs; Region: SDR_c; cd05233 485918012089 NAD(P) binding site [chemical binding]; other site 485918012090 active site 485918012091 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918012092 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918012093 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 485918012094 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 485918012095 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 485918012096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 485918012097 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 485918012098 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 485918012099 NADP binding site [chemical binding]; other site 485918012100 substrate binding site [chemical binding]; other site 485918012101 active site 485918012102 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918012103 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918012104 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918012105 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918012106 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 485918012107 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 485918012108 biotin synthase; Region: bioB; TIGR00433 485918012109 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 485918012110 FeS/SAM binding site; other site 485918012111 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 485918012112 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 485918012113 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 485918012114 DNA-binding site [nucleotide binding]; DNA binding site 485918012115 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 485918012116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918012117 homodimer interface [polypeptide binding]; other site 485918012118 catalytic residue [active] 485918012119 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 485918012120 Leucine rich repeat; Region: LRR_8; pfam13855 485918012121 Leucine rich repeat; Region: LRR_8; pfam13855 485918012122 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 485918012123 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 485918012124 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918012125 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 485918012126 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 485918012127 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918012128 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918012129 ligand binding site [chemical binding]; other site 485918012130 flexible hinge region; other site 485918012131 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 485918012132 Protein of unknown function (DUF805); Region: DUF805; pfam05656 485918012133 RibD C-terminal domain; Region: RibD_C; cl17279 485918012134 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 485918012135 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 485918012136 dimer interface [polypeptide binding]; other site 485918012137 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918012138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918012139 putative substrate translocation pore; other site 485918012140 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918012141 SusD family; Region: SusD; pfam07980 485918012142 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918012143 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918012144 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918012145 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 485918012146 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 485918012147 non-specific DNA binding site [nucleotide binding]; other site 485918012148 salt bridge; other site 485918012149 sequence-specific DNA binding site [nucleotide binding]; other site 485918012150 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 485918012151 CheB methylesterase; Region: CheB_methylest; pfam01339 485918012152 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918012153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918012154 active site 485918012155 phosphorylation site [posttranslational modification] 485918012156 intermolecular recognition site; other site 485918012157 dimerization interface [polypeptide binding]; other site 485918012158 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918012159 Putative addiction module component; Region: Unstab_antitox; cl09921 485918012160 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 485918012161 FecR protein; Region: FecR; pfam04773 485918012162 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918012163 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918012164 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918012165 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918012166 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 485918012167 Domain of unknown function (DUF389); Region: DUF389; pfam04087 485918012168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918012169 NAD(P) binding site [chemical binding]; other site 485918012170 short chain dehydrogenase; Provisional; Region: PRK06181 485918012171 active site 485918012172 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 485918012173 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 485918012174 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 485918012175 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; cl02380 485918012176 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 485918012177 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 485918012178 metal ion-dependent adhesion site (MIDAS); other site 485918012179 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 485918012180 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 485918012181 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 485918012182 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 485918012183 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 485918012184 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 485918012185 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 485918012186 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 485918012187 active site 485918012188 metal binding site [ion binding]; metal-binding site 485918012189 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 485918012190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918012191 Walker A/P-loop; other site 485918012192 ATP binding site [chemical binding]; other site 485918012193 Q-loop/lid; other site 485918012194 ABC transporter signature motif; other site 485918012195 Walker B; other site 485918012196 D-loop; other site 485918012197 H-loop/switch region; other site 485918012198 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 485918012199 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918012200 Coenzyme A binding pocket [chemical binding]; other site 485918012201 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 485918012202 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918012203 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918012204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918012205 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 485918012206 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 485918012207 NAD(P) binding site [chemical binding]; other site 485918012208 active site 485918012209 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918012210 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918012211 Protein of unknown function (DUF416); Region: DUF416; pfam04222 485918012212 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918012213 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 485918012214 NADP binding site [chemical binding]; other site 485918012215 active site 485918012216 steroid binding site; other site 485918012217 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918012218 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918012219 Integral membrane protein DUF92; Region: DUF92; pfam01940 485918012220 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 485918012221 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 485918012222 Surface antigen; Region: Bac_surface_Ag; pfam01103 485918012223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918012224 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 485918012225 putative substrate translocation pore; other site 485918012226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918012227 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918012228 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918012229 ligand binding site [chemical binding]; other site 485918012230 flexible hinge region; other site 485918012231 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 485918012232 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 485918012233 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 485918012234 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 485918012235 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 485918012236 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 485918012237 Cl binding site [ion binding]; other site 485918012238 oligomer interface [polypeptide binding]; other site 485918012239 NUDIX domain; Region: NUDIX; pfam00293 485918012240 nudix motif; other site 485918012241 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 485918012242 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 485918012243 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 485918012244 active site 485918012245 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918012246 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918012247 short chain dehydrogenase; Validated; Region: PRK06182 485918012248 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918012249 NADP binding site [chemical binding]; other site 485918012250 active site 485918012251 steroid binding site; other site 485918012252 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 485918012253 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 485918012254 active site 485918012255 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 485918012256 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 485918012257 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 485918012258 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 485918012259 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 485918012260 active site 485918012261 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 485918012262 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 485918012263 active site 485918012264 homodimer interface [polypeptide binding]; other site 485918012265 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 485918012266 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 485918012267 NlpC/P60 family; Region: NLPC_P60; pfam00877 485918012268 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 485918012269 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 485918012270 active site 485918012271 PHP Thumb interface [polypeptide binding]; other site 485918012272 metal binding site [ion binding]; metal-binding site 485918012273 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 485918012274 generic binding surface II; other site 485918012275 generic binding surface I; other site 485918012276 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 485918012277 catalytic residues [active] 485918012278 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 485918012279 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918012280 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 485918012281 active site 485918012282 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918012283 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 485918012284 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 485918012285 FeS/SAM binding site; other site 485918012286 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 485918012287 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 485918012288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918012289 active site 485918012290 phosphorylation site [posttranslational modification] 485918012291 intermolecular recognition site; other site 485918012292 dimerization interface [polypeptide binding]; other site 485918012293 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918012294 Walker A motif; other site 485918012295 ATP binding site [chemical binding]; other site 485918012296 Walker B motif; other site 485918012297 arginine finger; other site 485918012298 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 485918012299 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 485918012300 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 485918012301 Cytochrome c; Region: Cytochrom_C; pfam00034 485918012302 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 485918012303 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 485918012304 Nucleoside recognition; Region: Gate; pfam07670 485918012305 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 485918012306 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 485918012307 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 485918012308 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 485918012309 Walker A/P-loop; other site 485918012310 ATP binding site [chemical binding]; other site 485918012311 Q-loop/lid; other site 485918012312 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 485918012313 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 485918012314 ABC transporter signature motif; other site 485918012315 Walker B; other site 485918012316 D-loop; other site 485918012317 H-loop/switch region; other site 485918012318 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 485918012319 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 485918012320 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 485918012321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 485918012322 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 485918012323 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 485918012324 ligand binding site; other site 485918012325 oligomer interface; other site 485918012326 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 485918012327 dimer interface [polypeptide binding]; other site 485918012328 N-terminal domain interface [polypeptide binding]; other site 485918012329 sulfate 1 binding site; other site 485918012330 glycogen synthase; Provisional; Region: glgA; PRK00654 485918012331 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 485918012332 ADP-binding pocket [chemical binding]; other site 485918012333 homodimer interface [polypeptide binding]; other site 485918012334 Protein of unknown function DUF72; Region: DUF72; pfam01904 485918012335 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 485918012336 FAD binding domain; Region: FAD_binding_4; pfam01565 485918012337 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 485918012338 Family of unknown function (DUF706); Region: DUF706; pfam05153 485918012339 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 485918012340 putative transporter; Provisional; Region: PRK10484 485918012341 Na binding site [ion binding]; other site 485918012342 substrate binding site [chemical binding]; other site 485918012343 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 485918012344 substrate binding pocket [chemical binding]; other site 485918012345 substrate-Mg2+ binding site; other site 485918012346 aspartate-rich region 1; other site 485918012347 aspartate-rich region 2; other site 485918012348 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 485918012349 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 485918012350 active site 485918012351 metal binding site [ion binding]; metal-binding site 485918012352 nudix motif; other site 485918012353 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 485918012354 GAF domain; Region: GAF_2; pfam13185 485918012355 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 485918012356 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 485918012357 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 485918012358 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 485918012359 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918012360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918012361 active site 485918012362 phosphorylation site [posttranslational modification] 485918012363 intermolecular recognition site; other site 485918012364 dimerization interface [polypeptide binding]; other site 485918012365 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918012366 DNA binding residues [nucleotide binding] 485918012367 dimerization interface [polypeptide binding]; other site 485918012368 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 485918012369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918012370 Walker A motif; other site 485918012371 ATP binding site [chemical binding]; other site 485918012372 Walker B motif; other site 485918012373 arginine finger; other site 485918012374 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 485918012375 Trehalose utilisation; Region: ThuA; pfam06283 485918012376 SWI complex, BAF60b domains; Region: SWIB; smart00151 485918012377 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 485918012378 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 485918012379 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918012380 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 485918012381 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 485918012382 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 485918012383 putative trimer interface [polypeptide binding]; other site 485918012384 putative CoA binding site [chemical binding]; other site 485918012385 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 485918012386 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 485918012387 Mg++ binding site [ion binding]; other site 485918012388 putative catalytic motif [active] 485918012389 putative substrate binding site [chemical binding]; other site 485918012390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918012391 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 485918012392 NAD(P) binding site [chemical binding]; other site 485918012393 active site 485918012394 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 485918012395 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 485918012396 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 485918012397 active site 485918012398 homodimer interface [polypeptide binding]; other site 485918012399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918012400 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 485918012401 NAD(P) binding site [chemical binding]; other site 485918012402 active site 485918012403 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 485918012404 WxcM-like, C-terminal; Region: FdtA; pfam05523 485918012405 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 485918012406 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 485918012407 NAD(P) binding site [chemical binding]; other site 485918012408 homodimer interface [polypeptide binding]; other site 485918012409 substrate binding site [chemical binding]; other site 485918012410 active site 485918012411 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 485918012412 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 485918012413 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 485918012414 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 485918012415 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 485918012416 Right handed beta helix region; Region: Beta_helix; pfam13229 485918012417 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 485918012418 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 485918012419 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 485918012420 active site 485918012421 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 485918012422 homodimer interface [polypeptide binding]; other site 485918012423 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 485918012424 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 485918012425 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 485918012426 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 485918012427 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 485918012428 putative trimer interface [polypeptide binding]; other site 485918012429 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 485918012430 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 485918012431 putative CoA binding site [chemical binding]; other site 485918012432 putative trimer interface [polypeptide binding]; other site 485918012433 putative active site [active] 485918012434 putative substrate binding site [chemical binding]; other site 485918012435 putative CoA binding site [chemical binding]; other site 485918012436 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 485918012437 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 485918012438 inhibitor-cofactor binding pocket; inhibition site 485918012439 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918012440 catalytic residue [active] 485918012441 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 485918012442 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 485918012443 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 485918012444 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 485918012445 Chain length determinant protein; Region: Wzz; pfam02706 485918012446 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 485918012447 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 485918012448 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 485918012449 SLBB domain; Region: SLBB; pfam10531 485918012450 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 485918012451 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 485918012452 NAD(P) binding site [chemical binding]; other site 485918012453 homodimer interface [polypeptide binding]; other site 485918012454 substrate binding site [chemical binding]; other site 485918012455 active site 485918012456 LytTr DNA-binding domain; Region: LytTR; smart00850 485918012457 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 485918012458 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 485918012459 non-specific DNA binding site [nucleotide binding]; other site 485918012460 salt bridge; other site 485918012461 sequence-specific DNA binding site [nucleotide binding]; other site 485918012462 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 485918012463 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 485918012464 non-specific DNA binding site [nucleotide binding]; other site 485918012465 salt bridge; other site 485918012466 sequence-specific DNA binding site [nucleotide binding]; other site 485918012467 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cl10029 485918012468 catalytic residues [active] 485918012469 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 485918012470 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 485918012471 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 485918012472 active site 485918012473 DNA binding site [nucleotide binding] 485918012474 Int/Topo IB signature motif; other site 485918012475 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 485918012476 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 485918012477 active site 485918012478 DNA binding site [nucleotide binding] 485918012479 Int/Topo IB signature motif; other site 485918012480 DNA primase, catalytic core; Region: dnaG; TIGR01391 485918012481 CHC2 zinc finger; Region: zf-CHC2; cl17510 485918012482 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 485918012483 active site 485918012484 metal binding site [ion binding]; metal-binding site 485918012485 interdomain interaction site; other site 485918012486 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 485918012487 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 485918012488 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 485918012489 non-specific DNA binding site [nucleotide binding]; other site 485918012490 salt bridge; other site 485918012491 sequence-specific DNA binding site [nucleotide binding]; other site 485918012492 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 485918012493 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 485918012494 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 485918012495 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 485918012496 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 485918012497 potential catalytic triad [active] 485918012498 conserved cys residue [active] 485918012499 Uncharacterized conserved protein [Function unknown]; Region: COG1359 485918012500 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918012501 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918012502 ligand binding site [chemical binding]; other site 485918012503 flexible hinge region; other site 485918012504 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 485918012505 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 485918012506 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 485918012507 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918012508 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 485918012509 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918012510 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 485918012511 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 485918012512 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 485918012513 Predicted transcriptional regulator [Transcription]; Region: COG2345 485918012514 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 485918012515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918012516 Major Facilitator Superfamily; Region: MFS_1; pfam07690 485918012517 putative substrate translocation pore; other site 485918012518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918012519 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 485918012520 DNA-binding site [nucleotide binding]; DNA binding site 485918012521 Transcriptional regulators [Transcription]; Region: PurR; COG1609 485918012522 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 485918012523 putative dimerization interface [polypeptide binding]; other site 485918012524 putative ligand binding site [chemical binding]; other site 485918012525 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918012526 Coenzyme A binding pocket [chemical binding]; other site 485918012527 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 485918012528 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 485918012529 DNA-binding site [nucleotide binding]; DNA binding site 485918012530 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 485918012531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918012532 homodimer interface [polypeptide binding]; other site 485918012533 catalytic residue [active] 485918012534 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 485918012535 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 485918012536 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 485918012537 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 485918012538 sugar binding site [chemical binding]; other site 485918012539 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918012540 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918012541 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918012542 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918012543 SusD family; Region: SusD; pfam07980 485918012544 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918012545 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 485918012546 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918012547 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918012548 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918012549 SusD family; Region: SusD; pfam07980 485918012550 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918012551 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918012552 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918012553 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918012554 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918012555 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 485918012556 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 485918012557 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 485918012558 active site 485918012559 catalytic triad [active] 485918012560 oxyanion hole [active] 485918012561 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 485918012562 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 485918012563 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 485918012564 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918012565 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918012566 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918012567 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918012568 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918012569 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918012570 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918012571 FecR protein; Region: FecR; pfam04773 485918012572 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918012573 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918012574 DNA binding residues [nucleotide binding] 485918012575 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 485918012576 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 485918012577 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 485918012578 putative sugar binding sites [chemical binding]; other site 485918012579 Q-X-W motif; other site 485918012580 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 485918012581 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 485918012582 dimerization interface [polypeptide binding]; other site 485918012583 putative DNA binding site [nucleotide binding]; other site 485918012584 putative Zn2+ binding site [ion binding]; other site 485918012585 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 485918012586 hydrophobic ligand binding site; other site 485918012587 DoxX-like family; Region: DoxX_2; pfam13564 485918012588 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 485918012589 EamA-like transporter family; Region: EamA; pfam00892 485918012590 short chain dehydrogenase; Validated; Region: PRK06182 485918012591 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918012592 NADP binding site [chemical binding]; other site 485918012593 active site 485918012594 steroid binding site; other site 485918012595 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918012596 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918012597 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 485918012598 FAD binding domain; Region: FAD_binding_4; pfam01565 485918012599 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 485918012600 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 485918012601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 485918012602 non-specific DNA binding site [nucleotide binding]; other site 485918012603 salt bridge; other site 485918012604 sequence-specific DNA binding site [nucleotide binding]; other site 485918012605 Cupin domain; Region: Cupin_2; pfam07883 485918012606 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 485918012607 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 485918012608 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 485918012609 motif II; other site 485918012610 PAS domain S-box; Region: sensory_box; TIGR00229 485918012611 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918012612 putative active site [active] 485918012613 heme pocket [chemical binding]; other site 485918012614 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918012615 PAS fold; Region: PAS_3; pfam08447 485918012616 putative active site [active] 485918012617 heme pocket [chemical binding]; other site 485918012618 PAS domain S-box; Region: sensory_box; TIGR00229 485918012619 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918012620 putative active site [active] 485918012621 heme pocket [chemical binding]; other site 485918012622 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 485918012623 classical (c) SDRs; Region: SDR_c; cd05233 485918012624 NAD(P) binding site [chemical binding]; other site 485918012625 active site 485918012626 mannonate dehydratase; Provisional; Region: PRK03906 485918012627 mannonate dehydratase; Region: uxuA; TIGR00695 485918012628 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 485918012629 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 485918012630 Transcriptional regulators [Transcription]; Region: PurR; COG1609 485918012631 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 485918012632 DNA binding site [nucleotide binding] 485918012633 domain linker motif; other site 485918012634 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 485918012635 dimerization interface [polypeptide binding]; other site 485918012636 ligand binding site [chemical binding]; other site 485918012637 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 485918012638 substrate binding site [chemical binding]; other site 485918012639 active site 485918012640 Domain of unknown function (DUF303); Region: DUF303; pfam03629 485918012641 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 485918012642 Domain of unknown function (DUF303); Region: DUF303; pfam03629 485918012643 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918012644 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918012645 SusD family; Region: SusD; pfam07980 485918012646 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918012647 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918012648 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918012649 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918012650 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 485918012651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918012652 active site 485918012653 phosphorylation site [posttranslational modification] 485918012654 intermolecular recognition site; other site 485918012655 dimerization interface [polypeptide binding]; other site 485918012656 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 485918012657 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918012658 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918012659 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918012660 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918012661 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918012662 binding surface 485918012663 TPR motif; other site 485918012664 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918012665 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918012666 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 485918012667 binding surface 485918012668 TPR motif; other site 485918012669 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 485918012670 Histidine kinase; Region: HisKA_2; pfam07568 485918012671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918012672 ATP binding site [chemical binding]; other site 485918012673 Mg2+ binding site [ion binding]; other site 485918012674 G-X-G motif; other site 485918012675 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918012676 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 485918012677 Histidine kinase; Region: HisKA_2; pfam07568 485918012678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918012679 Mg2+ binding site [ion binding]; other site 485918012680 G-X-G motif; other site 485918012681 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 485918012682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918012683 active site 485918012684 phosphorylation site [posttranslational modification] 485918012685 intermolecular recognition site; other site 485918012686 dimerization interface [polypeptide binding]; other site 485918012687 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918012688 Walker A motif; other site 485918012689 ATP binding site [chemical binding]; other site 485918012690 Walker B motif; other site 485918012691 arginine finger; other site 485918012692 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 485918012693 GAF domain; Region: GAF_3; pfam13492 485918012694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918012695 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 485918012696 Walker A motif; other site 485918012697 ATP binding site [chemical binding]; other site 485918012698 Walker B motif; other site 485918012699 arginine finger; other site 485918012700 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 485918012701 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 485918012702 active site 485918012703 catalytic triad [active] 485918012704 oxyanion hole [active] 485918012705 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 485918012706 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 485918012707 putative sugar binding sites [chemical binding]; other site 485918012708 Q-X-W motif; other site 485918012709 Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576 485918012710 putative ligand binding site [chemical binding]; other site 485918012711 putative catalytic site [active] 485918012712 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 485918012713 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 485918012714 putative sugar binding sites [chemical binding]; other site 485918012715 Q-X-W motif; other site 485918012716 Domain of unknown function (DUF303); Region: DUF303; pfam03629 485918012717 transcriptional activator RhaS; Provisional; Region: PRK13503 485918012718 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918012719 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 485918012720 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 485918012721 putative NAD(P) binding site [chemical binding]; other site 485918012722 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 485918012723 protein-splicing catalytic site; other site 485918012724 thioester formation/cholesterol transfer; other site 485918012725 Pretoxin HINT domain; Region: PT-HINT; pfam07591 485918012726 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 485918012727 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 485918012728 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 485918012729 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 485918012730 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 485918012731 Protein of unknown function (DUF877); Region: DUF877; pfam05943 485918012732 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 485918012733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918012734 Walker A motif; other site 485918012735 ATP binding site [chemical binding]; other site 485918012736 Walker B motif; other site 485918012737 arginine finger; other site 485918012738 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918012739 Walker A motif; other site 485918012740 ATP binding site [chemical binding]; other site 485918012741 Walker B motif; other site 485918012742 arginine finger; other site 485918012743 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 485918012744 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 485918012745 metal ion-dependent adhesion site (MIDAS); other site 485918012746 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 485918012747 PKD domain; Region: PKD; pfam00801 485918012748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 485918012749 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 485918012750 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 485918012751 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 485918012752 catalytic Zn binding site [ion binding]; other site 485918012753 structural Zn binding site [ion binding]; other site 485918012754 NAD(P) binding site [chemical binding]; other site 485918012755 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 485918012756 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 485918012757 Sulfatase; Region: Sulfatase; pfam00884 485918012758 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 485918012759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918012760 active site 485918012761 phosphorylation site [posttranslational modification] 485918012762 intermolecular recognition site; other site 485918012763 dimerization interface [polypeptide binding]; other site 485918012764 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 485918012765 DNA binding site [nucleotide binding] 485918012766 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918012767 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918012768 dimer interface [polypeptide binding]; other site 485918012769 phosphorylation site [posttranslational modification] 485918012770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918012771 Mg2+ binding site [ion binding]; other site 485918012772 G-X-G motif; other site 485918012773 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918012774 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918012775 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918012776 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918012777 exonuclease subunit SbcD; Provisional; Region: PRK10966 485918012778 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 485918012779 active site 485918012780 metal binding site [ion binding]; metal-binding site 485918012781 DNA binding site [nucleotide binding] 485918012782 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 485918012783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918012784 AAA domain; Region: AAA_23; pfam13476 485918012785 Walker A/P-loop; other site 485918012786 ATP binding site [chemical binding]; other site 485918012787 Q-loop/lid; other site 485918012788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918012789 ABC transporter signature motif; other site 485918012790 Walker B; other site 485918012791 D-loop; other site 485918012792 H-loop/switch region; other site 485918012793 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 485918012794 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 485918012795 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 485918012796 putative acyl-acceptor binding pocket; other site 485918012797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918012798 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918012799 active site 485918012800 phosphorylation site [posttranslational modification] 485918012801 intermolecular recognition site; other site 485918012802 dimerization interface [polypeptide binding]; other site 485918012803 Mitochondrial inner membrane protein; Region: Mitofilin; pfam09731 485918012804 DinB superfamily; Region: DinB_2; pfam12867 485918012805 short chain dehydrogenase; Provisional; Region: PRK06500 485918012806 classical (c) SDRs; Region: SDR_c; cd05233 485918012807 NAD(P) binding site [chemical binding]; other site 485918012808 active site 485918012809 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918012810 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918012811 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 485918012812 Phage Tail Collar Domain; Region: Collar; pfam07484 485918012813 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 485918012814 Phage Tail Collar Domain; Region: Collar; pfam07484 485918012815 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 485918012816 Phage Tail Collar Domain; Region: Collar; pfam07484 485918012817 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 485918012818 active site 485918012819 substrate binding site [chemical binding]; other site 485918012820 cosubstrate binding site; other site 485918012821 catalytic site [active] 485918012822 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 485918012823 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 485918012824 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 485918012825 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 485918012826 active site 485918012827 dimer interface [polypeptide binding]; other site 485918012828 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 485918012829 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 485918012830 Ligand Binding Site [chemical binding]; other site 485918012831 Molecular Tunnel; other site 485918012832 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 485918012833 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 485918012834 active site 485918012835 metal-binding site [ion binding] 485918012836 nucleotide-binding site [chemical binding]; other site 485918012837 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 485918012838 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 485918012839 active site 485918012840 catalytic residues [active] 485918012841 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 485918012842 sugar binding site [chemical binding]; other site 485918012843 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 485918012844 FMN-binding domain; Region: FMN_bind; cl01081 485918012845 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 485918012846 sugar binding site [chemical binding]; other site 485918012847 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 485918012848 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918012849 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 485918012850 active site 485918012851 catalytic residues [active] 485918012852 CotH protein; Region: CotH; pfam08757 485918012853 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 485918012854 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 485918012855 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 485918012856 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 485918012857 Domain of unknown function (DUF718); Region: DUF718; pfam05336 485918012858 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 485918012859 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 485918012860 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 485918012861 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 485918012862 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 485918012863 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 485918012864 Cysteine-rich domain; Region: CCG; pfam02754 485918012865 Cysteine-rich domain; Region: CCG; pfam02754 485918012866 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 485918012867 nucleotide binding site [chemical binding]; other site 485918012868 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 485918012869 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 485918012870 short chain dehydrogenase; Validated; Region: PRK08324 485918012871 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 485918012872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918012873 NAD(P) binding site [chemical binding]; other site 485918012874 active site 485918012875 rhamnose-proton symporter; Provisional; Region: PRK13499 485918012876 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 485918012877 PAS fold; Region: PAS_3; pfam08447 485918012878 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918012879 putative active site [active] 485918012880 heme pocket [chemical binding]; other site 485918012881 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918012882 PAS domain; Region: PAS_9; pfam13426 485918012883 putative active site [active] 485918012884 heme pocket [chemical binding]; other site 485918012885 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918012886 dimer interface [polypeptide binding]; other site 485918012887 phosphorylation site [posttranslational modification] 485918012888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918012889 ATP binding site [chemical binding]; other site 485918012890 Mg2+ binding site [ion binding]; other site 485918012891 G-X-G motif; other site 485918012892 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 485918012893 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 485918012894 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 485918012895 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 485918012896 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918012897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918012898 ATP binding site [chemical binding]; other site 485918012899 Mg2+ binding site [ion binding]; other site 485918012900 G-X-G motif; other site 485918012901 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 485918012902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918012903 active site 485918012904 phosphorylation site [posttranslational modification] 485918012905 intermolecular recognition site; other site 485918012906 dimerization interface [polypeptide binding]; other site 485918012907 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 485918012908 DNA binding site [nucleotide binding] 485918012909 MgtC family; Region: MgtC; pfam02308 485918012910 Predicted membrane protein [Function unknown]; Region: COG3174 485918012911 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 485918012912 PIF1-like helicase; Region: PIF1; pfam05970 485918012913 AAA domain; Region: AAA_30; pfam13604 485918012914 Family description; Region: UvrD_C_2; pfam13538 485918012915 Uncharacterized conserved protein [Function unknown]; Region: COG1912 485918012916 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 485918012917 dimerization interface [polypeptide binding]; other site 485918012918 HD domain; Region: HD_4; pfam13328 485918012919 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 485918012920 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918012921 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 485918012922 FtsX-like permease family; Region: FtsX; pfam02687 485918012923 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 485918012924 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 485918012925 Walker A/P-loop; other site 485918012926 ATP binding site [chemical binding]; other site 485918012927 Q-loop/lid; other site 485918012928 ABC transporter signature motif; other site 485918012929 Walker B; other site 485918012930 D-loop; other site 485918012931 H-loop/switch region; other site 485918012932 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 485918012933 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918012934 Outer membrane efflux protein; Region: OEP; pfam02321 485918012935 Outer membrane efflux protein; Region: OEP; pfam02321 485918012936 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 485918012937 non-specific DNA binding site [nucleotide binding]; other site 485918012938 sequence-specific DNA binding site [nucleotide binding]; other site 485918012939 salt bridge; other site 485918012940 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 485918012941 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 485918012942 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 485918012943 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 485918012944 metal-binding site [ion binding] 485918012945 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 485918012946 metal-binding site [ion binding] 485918012947 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 485918012948 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 485918012949 Soluble P-type ATPase [General function prediction only]; Region: COG4087 485918012950 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918012951 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918012952 MG2 domain; Region: A2M_N; pfam01835 485918012953 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918012954 Alpha-2-macroglobulin family; Region: A2M; pfam00207 485918012955 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 485918012956 PAS domain S-box; Region: sensory_box; TIGR00229 485918012957 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918012958 putative active site [active] 485918012959 heme pocket [chemical binding]; other site 485918012960 PAS fold; Region: PAS_3; pfam08447 485918012961 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918012962 dimer interface [polypeptide binding]; other site 485918012963 phosphorylation site [posttranslational modification] 485918012964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918012965 ATP binding site [chemical binding]; other site 485918012966 Mg2+ binding site [ion binding]; other site 485918012967 G-X-G motif; other site 485918012968 Response regulator receiver domain; Region: Response_reg; pfam00072 485918012969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918012970 active site 485918012971 phosphorylation site [posttranslational modification] 485918012972 intermolecular recognition site; other site 485918012973 dimerization interface [polypeptide binding]; other site 485918012974 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 485918012975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918012976 active site 485918012977 phosphorylation site [posttranslational modification] 485918012978 intermolecular recognition site; other site 485918012979 dimerization interface [polypeptide binding]; other site 485918012980 Hpt domain; Region: Hpt; pfam01627 485918012981 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 485918012982 Transcriptional regulators [Transcription]; Region: MarR; COG1846 485918012983 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 485918012984 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 485918012985 putative hydrophobic ligand binding site [chemical binding]; other site 485918012986 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 485918012987 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 485918012988 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 485918012989 Domain of unknown function (DUF427); Region: DUF427; pfam04248 485918012990 mercuric reductase; Validated; Region: PRK06370 485918012991 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 485918012992 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 485918012993 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 485918012994 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 485918012995 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918012996 Walker A/P-loop; other site 485918012997 ATP binding site [chemical binding]; other site 485918012998 Q-loop/lid; other site 485918012999 ABC transporter signature motif; other site 485918013000 Walker B; other site 485918013001 D-loop; other site 485918013002 H-loop/switch region; other site 485918013003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 485918013004 dimer interface [polypeptide binding]; other site 485918013005 conserved gate region; other site 485918013006 putative PBP binding loops; other site 485918013007 ABC-ATPase subunit interface; other site 485918013008 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 485918013009 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 485918013010 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 485918013011 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 485918013012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 485918013013 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 485918013014 DinB superfamily; Region: DinB_2; pfam12867 485918013015 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918013016 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918013017 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 485918013018 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 485918013019 dimer interface [polypeptide binding]; other site 485918013020 active site 485918013021 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 485918013022 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 485918013023 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918013024 putative active site [active] 485918013025 heme pocket [chemical binding]; other site 485918013026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918013027 dimer interface [polypeptide binding]; other site 485918013028 phosphorylation site [posttranslational modification] 485918013029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918013030 ATP binding site [chemical binding]; other site 485918013031 Mg2+ binding site [ion binding]; other site 485918013032 G-X-G motif; other site 485918013033 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 485918013034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918013035 active site 485918013036 phosphorylation site [posttranslational modification] 485918013037 intermolecular recognition site; other site 485918013038 Protein of unknown function (DUF3823); Region: DUF3823; pfam12866 485918013039 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918013040 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918013041 SusD family; Region: SusD; pfam07980 485918013042 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918013043 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918013044 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918013045 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 485918013046 putative metal binding site [ion binding]; other site 485918013047 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 485918013048 Right handed beta helix region; Region: Beta_helix; pfam13229 485918013049 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 485918013050 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 485918013051 Calx-beta domain; Region: Calx-beta; cl02522 485918013052 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_4; cd09619 485918013053 putative ligand binding site [chemical binding]; other site 485918013054 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 485918013055 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_4; cd09619 485918013056 putative ligand binding site [chemical binding]; other site 485918013057 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918013058 Transcriptional regulator [Transcription]; Region: LysR; COG0583 485918013059 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 485918013060 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 485918013061 putative dimerization interface [polypeptide binding]; other site 485918013062 Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins; Region: SRPBCC_Aha1; cd08892 485918013063 putative hydrophobic ligand binding site [chemical binding]; other site 485918013064 putative Hsp90 binding residues [polypeptide binding]; other site 485918013065 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 485918013066 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 485918013067 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918013068 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918013069 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 485918013070 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918013071 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918013072 DNA binding residues [nucleotide binding] 485918013073 Uncharacterized protein domain similar to Clostridium thermocellum 2751; Region: Cthe_2751_like; cd11743 485918013074 dimer interface [polypeptide binding]; other site 485918013075 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 485918013076 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918013077 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918013078 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918013079 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918013080 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918013081 SusD family; Region: SusD; pfam07980 485918013082 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 485918013083 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 485918013084 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 485918013085 active site 485918013086 Fn3 associated; Region: Fn3_assoc; pfam13287 485918013087 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 485918013088 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 485918013089 pseudouridine synthase; Region: TIGR00093 485918013090 active site 485918013091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 485918013092 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 485918013093 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 485918013094 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 485918013095 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 485918013096 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 485918013097 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918013098 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918013099 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 485918013100 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 485918013101 catalytic residues [active] 485918013102 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 485918013103 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 485918013104 Active site serine [active] 485918013105 Predicted membrane protein [Function unknown]; Region: COG2855 485918013106 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918013107 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918013108 WHG domain; Region: WHG; pfam13305 485918013109 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 485918013110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918013111 NAD(P) binding site [chemical binding]; other site 485918013112 active site 485918013113 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 485918013114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918013115 putative substrate translocation pore; other site 485918013116 Methyltransferase domain; Region: Methyltransf_31; pfam13847 485918013117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918013118 S-adenosylmethionine binding site [chemical binding]; other site 485918013119 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 485918013120 classical (c) SDRs; Region: SDR_c; cd05233 485918013121 NAD(P) binding site [chemical binding]; other site 485918013122 active site 485918013123 Pirin-related protein [General function prediction only]; Region: COG1741 485918013124 Pirin; Region: Pirin; pfam02678 485918013125 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 485918013126 putative FMN binding site [chemical binding]; other site 485918013127 Pirin-related protein [General function prediction only]; Region: COG1741 485918013128 Pirin; Region: Pirin; pfam02678 485918013129 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 485918013130 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 485918013131 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918013132 Zn binding site [ion binding]; other site 485918013133 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 485918013134 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918013135 Zn binding site [ion binding]; other site 485918013136 Predicted acetyltransferase [General function prediction only]; Region: COG2388 485918013137 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 485918013138 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918013139 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918013140 ligand binding site [chemical binding]; other site 485918013141 flexible hinge region; other site 485918013142 MG2 domain; Region: A2M_N; pfam01835 485918013143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918013144 putative substrate translocation pore; other site 485918013145 Major Facilitator Superfamily; Region: MFS_1; pfam07690 485918013146 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 485918013147 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 485918013148 active site 485918013149 motif I; other site 485918013150 motif II; other site 485918013151 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 485918013152 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 485918013153 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 485918013154 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 485918013155 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 485918013156 Phosphopantetheine attachment site; Region: PP-binding; cl09936 485918013157 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 485918013158 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 485918013159 dimer interface [polypeptide binding]; other site 485918013160 active site 485918013161 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 485918013162 active site 2 [active] 485918013163 dimer interface [polypeptide binding]; other site 485918013164 active site 1 [active] 485918013165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918013166 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 485918013167 NAD(P) binding site [chemical binding]; other site 485918013168 active site 485918013169 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 485918013170 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 485918013171 malonyl-CoA binding site [chemical binding]; other site 485918013172 dimer interface [polypeptide binding]; other site 485918013173 active site 485918013174 product binding site; other site 485918013175 Methyltransferase domain; Region: Methyltransf_31; pfam13847 485918013176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918013177 S-adenosylmethionine binding site [chemical binding]; other site 485918013178 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 485918013179 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 485918013180 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 485918013181 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 485918013182 dimanganese center [ion binding]; other site 485918013183 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 485918013184 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 485918013185 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 485918013186 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 485918013187 active site 485918013188 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 485918013189 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 485918013190 putative active site [active] 485918013191 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 485918013192 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 485918013193 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 485918013194 putative active site [active] 485918013195 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 485918013196 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 485918013197 substrate binding site [chemical binding]; other site 485918013198 ATP binding site [chemical binding]; other site 485918013199 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 485918013200 active site 485918013201 HIGH motif; other site 485918013202 nucleotide binding site [chemical binding]; other site 485918013203 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 485918013204 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 485918013205 active site 485918013206 motif I; other site 485918013207 motif II; other site 485918013208 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 485918013209 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 485918013210 putative ADP-binding pocket [chemical binding]; other site 485918013211 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 485918013212 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 485918013213 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 485918013214 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 485918013215 NAD binding site [chemical binding]; other site 485918013216 catalytic Zn binding site [ion binding]; other site 485918013217 structural Zn binding site [ion binding]; other site 485918013218 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 485918013219 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 485918013220 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 485918013221 iron-sulfur cluster [ion binding]; other site 485918013222 [2Fe-2S] cluster binding site [ion binding]; other site 485918013223 Competence-damaged protein; Region: CinA; pfam02464 485918013224 Major Facilitator Superfamily; Region: MFS_1; pfam07690 485918013225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918013226 Response regulator receiver domain; Region: Response_reg; pfam00072 485918013227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918013228 active site 485918013229 phosphorylation site [posttranslational modification] 485918013230 intermolecular recognition site; other site 485918013231 dimerization interface [polypeptide binding]; other site 485918013232 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 485918013233 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 485918013234 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918013235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918013236 active site 485918013237 phosphorylation site [posttranslational modification] 485918013238 intermolecular recognition site; other site 485918013239 dimerization interface [polypeptide binding]; other site 485918013240 LytTr DNA-binding domain; Region: LytTR; smart00850 485918013241 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918013242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918013243 binding surface 485918013244 TPR motif; other site 485918013245 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918013246 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918013247 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918013248 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918013249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918013250 dimer interface [polypeptide binding]; other site 485918013251 phosphorylation site [posttranslational modification] 485918013252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918013253 ATP binding site [chemical binding]; other site 485918013254 Mg2+ binding site [ion binding]; other site 485918013255 G-X-G motif; other site 485918013256 chaperone protein DnaJ; Provisional; Region: PRK14299 485918013257 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 485918013258 HSP70 interaction site [polypeptide binding]; other site 485918013259 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 485918013260 substrate binding site [polypeptide binding]; other site 485918013261 dimer interface [polypeptide binding]; other site 485918013262 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 485918013263 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 485918013264 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 485918013265 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 485918013266 active site 485918013267 catalytic triad [active] 485918013268 oxyanion hole [active] 485918013269 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 485918013270 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 485918013271 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 485918013272 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 485918013273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 485918013274 Trehalase; Region: Trehalase; cl17346 485918013275 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 485918013276 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 485918013277 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 485918013278 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 485918013279 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 485918013280 Carboxylesterase family; Region: COesterase; pfam00135 485918013281 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 485918013282 substrate binding pocket [chemical binding]; other site 485918013283 catalytic triad [active] 485918013284 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 485918013285 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 485918013286 NADP binding site [chemical binding]; other site 485918013287 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 485918013288 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 485918013289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315 485918013290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918013291 Major Facilitator Superfamily; Region: MFS_1; pfam07690 485918013292 putative substrate translocation pore; other site 485918013293 maltose phosphorylase; Provisional; Region: PRK13807 485918013294 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 485918013295 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 485918013296 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 485918013297 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 485918013298 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 485918013299 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 485918013300 Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087 485918013301 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340 485918013302 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 485918013303 Ca binding site [ion binding]; other site 485918013304 active site 485918013305 homodimer interface [polypeptide binding]; other site 485918013306 catalytic site [active] 485918013307 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 485918013308 SusE outer membrane protein; Region: SusE; pfam14292 485918013309 Uncharacterized subgroup of the CBM-SusE-F_like superfamily; Region: CBM_SusE-F_like_u1; cd12967 485918013310 starch binding site [chemical binding]; other site 485918013311 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 485918013312 starch binding site [chemical binding]; other site 485918013313 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918013314 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918013315 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918013316 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918013317 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918013318 Transcriptional regulators [Transcription]; Region: PurR; COG1609 485918013319 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 485918013320 DNA binding site [nucleotide binding] 485918013321 domain linker motif; other site 485918013322 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 485918013323 dimerization interface [polypeptide binding]; other site 485918013324 ligand binding site [chemical binding]; other site 485918013325 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 485918013326 sugar binding site [chemical binding]; other site 485918013327 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 485918013328 Calx-beta domain; Region: Calx-beta; cl02522 485918013329 Calx-beta domain; Region: Calx-beta; cl02522 485918013330 Calx-beta domain; Region: Calx-beta; cl02522 485918013331 Calx-beta domain; Region: Calx-beta; cl02522 485918013332 Calx-beta domain; Region: Calx-beta; cl02522 485918013333 Calx-beta domain; Region: Calx-beta; cl02522 485918013334 Calx-beta domain; Region: Calx-beta; cl02522 485918013335 Calx-beta domain; Region: Calx-beta; cl02522 485918013336 Calx-beta domain; Region: Calx-beta; cl02522 485918013337 Calx-beta domain; Region: Calx-beta; cl02522 485918013338 Calx-beta domain; Region: Calx-beta; cl02522 485918013339 Calx-beta domain; Region: Calx-beta; cl02522 485918013340 Calx-beta domain; Region: Calx-beta; cl02522 485918013341 Calx-beta domain; Region: Calx-beta; cl02522 485918013342 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918013343 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918013344 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918013345 WHG domain; Region: WHG; pfam13305 485918013346 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918013347 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918013348 Inclusion body protein; Region: PixA; pfam12306 485918013349 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 485918013350 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 485918013351 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 485918013352 proline aminopeptidase P II; Provisional; Region: PRK10879 485918013353 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 485918013354 active site 485918013355 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 485918013356 heme-binding site [chemical binding]; other site 485918013357 Domain of unknown function (DUF2024); Region: DUF2024; pfam09630 485918013358 Transcriptional regulators [Transcription]; Region: MarR; COG1846 485918013359 MarR family; Region: MarR_2; pfam12802 485918013360 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 485918013361 Beta-lactamase; Region: Beta-lactamase; pfam00144 485918013362 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 485918013363 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 485918013364 active site 485918013365 catalytic residues [active] 485918013366 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 485918013367 PKC phosphorylation site [posttranslational modification]; other site 485918013368 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 485918013369 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 485918013370 DNA binding residues [nucleotide binding] 485918013371 dimerization interface [polypeptide binding]; other site 485918013372 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 485918013373 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 485918013374 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918013375 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918013376 DNA binding residues [nucleotide binding] 485918013377 FecR protein; Region: FecR; pfam04773 485918013378 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918013379 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918013380 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918013381 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918013382 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918013383 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918013384 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 485918013385 active site 485918013386 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 485918013387 active site 485918013388 catalytic residues [active] 485918013389 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 485918013390 sugar binding site [chemical binding]; other site 485918013391 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918013392 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 485918013393 Immunoglobulin I-set domain; Region: I-set; pfam07679 485918013394 Immunoglobulin domain; Region: Ig; cd00096 485918013395 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 485918013396 putative metal binding site [ion binding]; other site 485918013397 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 485918013398 Ca binding site [ion binding]; other site 485918013399 ligand binding site I [chemical binding]; other site 485918013400 homodimer interface [polypeptide binding]; other site 485918013401 ligand binding site II [chemical binding]; other site 485918013402 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918013403 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 485918013404 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 485918013405 active site 485918013406 catalytic residues [active] 485918013407 metal binding site [ion binding]; metal-binding site 485918013408 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918013409 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918013410 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918013411 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 485918013412 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 485918013413 short chain dehydrogenase; Provisional; Region: PRK12747 485918013414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918013415 NAD(P) binding site [chemical binding]; other site 485918013416 active site 485918013417 short chain dehydrogenase; Provisional; Region: PRK06500 485918013418 classical (c) SDRs; Region: SDR_c; cd05233 485918013419 NAD(P) binding site [chemical binding]; other site 485918013420 active site 485918013421 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918013422 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918013423 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918013424 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918013425 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918013426 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 485918013427 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 485918013428 Penicillinase repressor; Region: Pencillinase_R; pfam03965 485918013429 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918013430 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 485918013431 FtsX-like permease family; Region: FtsX; pfam02687 485918013432 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918013433 FtsX-like permease family; Region: FtsX; pfam02687 485918013434 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918013435 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 485918013436 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 485918013437 N-terminal plug; other site 485918013438 ligand-binding site [chemical binding]; other site 485918013439 EthD domain; Region: EthD; cl17553 485918013440 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 485918013441 active site 485918013442 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918013443 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918013444 catalytic residues [active] 485918013445 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918013446 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918013447 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918013448 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918013449 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918013450 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918013451 FecR protein; Region: FecR; pfam04773 485918013452 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918013453 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918013454 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918013455 DNA binding residues [nucleotide binding] 485918013456 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 485918013457 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 485918013458 substrate binding site [chemical binding]; other site 485918013459 metal binding site [ion binding]; metal-binding site 485918013460 dimer interface [polypeptide binding]; other site 485918013461 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 485918013462 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 485918013463 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 485918013464 active site 485918013465 catalytic tetrad [active] 485918013466 PAS domain; Region: PAS_9; pfam13426 485918013467 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918013468 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918013469 DNA binding residues [nucleotide binding] 485918013470 dimerization interface [polypeptide binding]; other site 485918013471 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 485918013472 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918013473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918013474 Response regulator receiver domain; Region: Response_reg; pfam00072 485918013475 active site 485918013476 phosphorylation site [posttranslational modification] 485918013477 intermolecular recognition site; other site 485918013478 dimerization interface [polypeptide binding]; other site 485918013479 LytTr DNA-binding domain; Region: LytTR; smart00850 485918013480 Histidine kinase; Region: His_kinase; pfam06580 485918013481 RDD family; Region: RDD; pfam06271 485918013482 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 485918013483 DNA-binding site [nucleotide binding]; DNA binding site 485918013484 RNA-binding motif; other site 485918013485 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 485918013486 Class I aldolases; Region: Aldolase_Class_I; cl17187 485918013487 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 485918013488 PhnA protein; Region: PhnA; pfam03831 485918013489 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 485918013490 putative lyase; Provisional; Region: PRK09687 485918013491 exopolyphosphatase; Region: exo_poly_only; TIGR03706 485918013492 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 485918013493 RibD C-terminal domain; Region: RibD_C; cl17279 485918013494 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 485918013495 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 485918013496 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918013497 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 485918013498 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918013499 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 485918013500 Protein export membrane protein; Region: SecD_SecF; cl14618 485918013501 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 485918013502 Penicillinase repressor; Region: Pencillinase_R; cl17580 485918013503 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 485918013504 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 485918013505 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 485918013506 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 485918013507 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 485918013508 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 485918013509 active site 485918013510 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 485918013511 Condensation domain; Region: Condensation; pfam00668 485918013512 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918013513 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 485918013514 acyl-activating enzyme (AAE) consensus motif; other site 485918013515 AMP binding site [chemical binding]; other site 485918013516 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013517 Condensation domain; Region: Condensation; pfam00668 485918013518 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013519 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918013520 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 485918013521 acyl-activating enzyme (AAE) consensus motif; other site 485918013522 AMP binding site [chemical binding]; other site 485918013523 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013524 Condensation domain; Region: Condensation; pfam00668 485918013525 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013526 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918013527 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 485918013528 acyl-activating enzyme (AAE) consensus motif; other site 485918013529 AMP binding site [chemical binding]; other site 485918013530 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013531 Condensation domain; Region: Condensation; pfam00668 485918013532 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013533 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918013534 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 485918013535 acyl-activating enzyme (AAE) consensus motif; other site 485918013536 AMP binding site [chemical binding]; other site 485918013537 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013538 Condensation domain; Region: Condensation; pfam00668 485918013539 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013540 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918013541 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918013542 acyl-activating enzyme (AAE) consensus motif; other site 485918013543 AMP binding site [chemical binding]; other site 485918013544 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013545 Condensation domain; Region: Condensation; pfam00668 485918013546 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013547 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918013548 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918013549 acyl-activating enzyme (AAE) consensus motif; other site 485918013550 AMP binding site [chemical binding]; other site 485918013551 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013552 Condensation domain; Region: Condensation; pfam00668 485918013553 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013554 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 485918013555 Condensation domain; Region: Condensation; pfam00668 485918013556 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013557 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918013558 acyl-activating enzyme (AAE) consensus motif; other site 485918013559 AMP binding site [chemical binding]; other site 485918013560 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013561 Condensation domain; Region: Condensation; pfam00668 485918013562 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013563 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 485918013564 Condensation domain; Region: Condensation; pfam00668 485918013565 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013566 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918013567 acyl-activating enzyme (AAE) consensus motif; other site 485918013568 AMP binding site [chemical binding]; other site 485918013569 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013570 Condensation domain; Region: Condensation; pfam00668 485918013571 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013572 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 485918013573 Condensation domain; Region: Condensation; pfam00668 485918013574 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918013575 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 485918013576 acyl-activating enzyme (AAE) consensus motif; other site 485918013577 AMP binding site [chemical binding]; other site 485918013578 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013579 Condensation domain; Region: Condensation; pfam00668 485918013580 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013581 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 485918013582 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 485918013583 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 485918013584 acyl-activating enzyme (AAE) consensus motif; other site 485918013585 AMP binding site [chemical binding]; other site 485918013586 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013587 Condensation domain; Region: Condensation; pfam00668 485918013588 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013589 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918013590 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918013591 acyl-activating enzyme (AAE) consensus motif; other site 485918013592 AMP binding site [chemical binding]; other site 485918013593 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013594 Condensation domain; Region: Condensation; pfam00668 485918013595 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013596 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918013597 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918013598 acyl-activating enzyme (AAE) consensus motif; other site 485918013599 AMP binding site [chemical binding]; other site 485918013600 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013601 Condensation domain; Region: Condensation; pfam00668 485918013602 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013603 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918013604 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918013605 acyl-activating enzyme (AAE) consensus motif; other site 485918013606 AMP binding site [chemical binding]; other site 485918013607 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013608 Condensation domain; Region: Condensation; pfam00668 485918013609 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013610 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918013611 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918013612 acyl-activating enzyme (AAE) consensus motif; other site 485918013613 AMP binding site [chemical binding]; other site 485918013614 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013615 Condensation domain; Region: Condensation; pfam00668 485918013616 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013617 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918013618 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918013619 acyl-activating enzyme (AAE) consensus motif; other site 485918013620 AMP binding site [chemical binding]; other site 485918013621 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013622 Condensation domain; Region: Condensation; pfam00668 485918013623 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013624 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918013625 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918013626 acyl-activating enzyme (AAE) consensus motif; other site 485918013627 AMP binding site [chemical binding]; other site 485918013628 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013629 peptide synthase; Provisional; Region: PRK12467 485918013630 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918013631 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918013632 acyl-activating enzyme (AAE) consensus motif; other site 485918013633 AMP binding site [chemical binding]; other site 485918013634 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013635 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918013636 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918013637 acyl-activating enzyme (AAE) consensus motif; other site 485918013638 AMP binding site [chemical binding]; other site 485918013639 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013640 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 485918013641 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 485918013642 acyl-activating enzyme (AAE) consensus motif; other site 485918013643 AMP binding site [chemical binding]; other site 485918013644 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013645 Condensation domain; Region: Condensation; pfam00668 485918013646 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013647 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 485918013648 Condensation domain; Region: Condensation; pfam00668 485918013649 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013650 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918013651 acyl-activating enzyme (AAE) consensus motif; other site 485918013652 AMP binding site [chemical binding]; other site 485918013653 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013654 Condensation domain; Region: Condensation; pfam00668 485918013655 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013656 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 485918013657 Condensation domain; Region: Condensation; pfam00668 485918013658 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013659 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918013660 acyl-activating enzyme (AAE) consensus motif; other site 485918013661 AMP binding site [chemical binding]; other site 485918013662 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013663 Condensation domain; Region: Condensation; pfam00668 485918013664 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013665 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 485918013666 Condensation domain; Region: Condensation; pfam00668 485918013667 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918013668 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 485918013669 acyl-activating enzyme (AAE) consensus motif; other site 485918013670 AMP binding site [chemical binding]; other site 485918013671 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013672 Condensation domain; Region: Condensation; pfam00668 485918013673 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013674 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 485918013675 Condensation domain; Region: Condensation; pfam00668 485918013676 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013677 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 485918013678 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 485918013679 Predicted membrane protein (DUF2070); Region: DUF2070; pfam09843 485918013680 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 485918013681 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 485918013682 nucleophilic elbow; other site 485918013683 catalytic triad; other site 485918013684 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 485918013685 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918013686 Walker A/P-loop; other site 485918013687 ATP binding site [chemical binding]; other site 485918013688 Q-loop/lid; other site 485918013689 ABC transporter signature motif; other site 485918013690 Walker B; other site 485918013691 D-loop; other site 485918013692 H-loop/switch region; other site 485918013693 acyl-CoA synthetase; Validated; Region: PRK09192 485918013694 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 485918013695 acyl-activating enzyme (AAE) consensus motif; other site 485918013696 AMP binding site [chemical binding]; other site 485918013697 active site 485918013698 CoA binding site [chemical binding]; other site 485918013699 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013700 Condensation domain; Region: Condensation; pfam00668 485918013701 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918013702 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 485918013703 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 485918013704 acyl-activating enzyme (AAE) consensus motif; other site 485918013705 AMP binding site [chemical binding]; other site 485918013706 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013707 Condensation domain; Region: Condensation; pfam00668 485918013708 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 485918013709 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 485918013710 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 485918013711 acyl-activating enzyme (AAE) consensus motif; other site 485918013712 AMP binding site [chemical binding]; other site 485918013713 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013714 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918013715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918013716 active site 485918013717 phosphorylation site [posttranslational modification] 485918013718 intermolecular recognition site; other site 485918013719 dimerization interface [polypeptide binding]; other site 485918013720 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918013721 DNA binding residues [nucleotide binding] 485918013722 dimerization interface [polypeptide binding]; other site 485918013723 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 485918013724 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 485918013725 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918013726 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918013727 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 485918013728 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918013729 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918013730 SusD family; Region: SusD; pfam07980 485918013731 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918013732 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918013733 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918013734 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 485918013735 hydrophobic ligand binding site; other site 485918013736 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 485918013737 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 485918013738 conserved cys residue [active] 485918013739 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918013740 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918013741 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918013742 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 485918013743 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 485918013744 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 485918013745 classical (c) SDRs; Region: SDR_c; cd05233 485918013746 NAD(P) binding site [chemical binding]; other site 485918013747 active site 485918013748 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 485918013749 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 485918013750 NAD(P) binding site [chemical binding]; other site 485918013751 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918013752 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918013753 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 485918013754 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 485918013755 catalytic residues [active] 485918013756 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 485918013757 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 485918013758 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 485918013759 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918013760 TAP-like protein; Region: Abhydrolase_4; pfam08386 485918013761 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 485918013762 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 485918013763 FMN binding site [chemical binding]; other site 485918013764 active site 485918013765 substrate binding site [chemical binding]; other site 485918013766 catalytic residue [active] 485918013767 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918013768 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918013769 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 485918013770 Peptidase family M48; Region: Peptidase_M48; cl12018 485918013771 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 485918013772 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918013773 PGAP1-like protein; Region: PGAP1; pfam07819 485918013774 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 485918013775 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 485918013776 active site 485918013777 metal binding site [ion binding]; metal-binding site 485918013778 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 485918013779 nudix motif; other site 485918013780 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918013781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918013782 active site 485918013783 phosphorylation site [posttranslational modification] 485918013784 intermolecular recognition site; other site 485918013785 dimerization interface [polypeptide binding]; other site 485918013786 LytTr DNA-binding domain; Region: LytTR; pfam04397 485918013787 Histidine kinase; Region: His_kinase; pfam06580 485918013788 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 485918013789 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 485918013790 Walker A/P-loop; other site 485918013791 ATP binding site [chemical binding]; other site 485918013792 Q-loop/lid; other site 485918013793 ABC transporter signature motif; other site 485918013794 Walker B; other site 485918013795 D-loop; other site 485918013796 H-loop/switch region; other site 485918013797 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 485918013798 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 485918013799 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 485918013800 Zn binding site [ion binding]; other site 485918013801 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 485918013802 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918013803 Uncharacterized conserved protein [Function unknown]; Region: COG5476 485918013804 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 485918013805 MlrC C-terminus; Region: MlrC_C; pfam07171 485918013806 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 485918013807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918013808 Walker A motif; other site 485918013809 ATP binding site [chemical binding]; other site 485918013810 Walker B motif; other site 485918013811 arginine finger; other site 485918013812 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 485918013813 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 485918013814 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 485918013815 P-loop; other site 485918013816 Magnesium ion binding site [ion binding]; other site 485918013817 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 485918013818 Magnesium ion binding site [ion binding]; other site 485918013819 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 485918013820 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 485918013821 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 485918013822 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 485918013823 aromatic chitin/cellulose binding site residues [chemical binding]; other site 485918013824 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 485918013825 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 485918013826 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 485918013827 Uncharacterized conserved protein [Function unknown]; Region: COG4104 485918013828 Phage protein D [General function prediction only]; Region: COG3500 485918013829 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 485918013830 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 485918013831 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 485918013832 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 485918013833 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 485918013834 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 485918013835 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 485918013836 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 485918013837 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 485918013838 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 485918013839 active site 485918013840 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 485918013841 CHAT domain; Region: CHAT; cl17868 485918013842 AAA ATPase domain; Region: AAA_16; pfam13191 485918013843 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 485918013844 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918013845 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918013846 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 485918013847 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 485918013848 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 485918013849 Peptidase family M48; Region: Peptidase_M48; cl12018 485918013850 Predicted membrane protein [Function unknown]; Region: COG3059 485918013851 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918013852 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918013853 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 485918013854 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 485918013855 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 485918013856 ligand binding site [chemical binding]; other site 485918013857 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 485918013858 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918013859 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 485918013860 active site 485918013861 metal binding site [ion binding]; metal-binding site 485918013862 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 485918013863 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 485918013864 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918013865 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918013866 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918013867 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918013868 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918013869 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918013870 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918013871 FecR protein; Region: FecR; pfam04773 485918013872 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918013873 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918013874 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 485918013875 DNA binding residues [nucleotide binding] 485918013876 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 485918013877 mce related protein; Region: MCE; pfam02470 485918013878 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 485918013879 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 485918013880 Walker A/P-loop; other site 485918013881 ATP binding site [chemical binding]; other site 485918013882 Q-loop/lid; other site 485918013883 ABC transporter signature motif; other site 485918013884 Walker B; other site 485918013885 D-loop; other site 485918013886 H-loop/switch region; other site 485918013887 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 485918013888 Permease; Region: Permease; pfam02405 485918013889 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 485918013890 FAD binding domain; Region: FAD_binding_4; pfam01565 485918013891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918013892 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 485918013893 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 485918013894 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 485918013895 putative NADP binding site [chemical binding]; other site 485918013896 active site 485918013897 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013898 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 485918013899 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 485918013900 active site 485918013901 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013902 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 485918013903 Methyltransferase domain; Region: Methyltransf_23; pfam13489 485918013904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918013905 S-adenosylmethionine binding site [chemical binding]; other site 485918013906 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013907 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 485918013908 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 485918013909 active site 485918013910 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 485918013911 putative NADP binding site [chemical binding]; other site 485918013912 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 485918013913 active site 485918013914 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013915 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 485918013916 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 485918013917 active site 485918013918 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 485918013919 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 485918013920 putative NADP binding site [chemical binding]; other site 485918013921 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 485918013922 active site 485918013923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918013924 S-adenosylmethionine binding site [chemical binding]; other site 485918013925 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013926 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 485918013927 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 485918013928 active site 485918013929 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 485918013930 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 485918013931 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 485918013932 KR domain; Region: KR; pfam08659 485918013933 putative NADP binding site [chemical binding]; other site 485918013934 active site 485918013935 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 485918013936 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 485918013937 active site 485918013938 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013939 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 485918013940 putative NADP binding site [chemical binding]; other site 485918013941 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 485918013942 active site 485918013943 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013944 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 485918013945 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 485918013946 active site 485918013947 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 485918013948 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 485918013949 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 485918013950 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 485918013951 active site 485918013952 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 485918013953 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 485918013954 putative NADP binding site [chemical binding]; other site 485918013955 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 485918013956 active site 485918013957 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 485918013958 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 485918013959 active site 485918013960 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 485918013961 putative NADP binding site [chemical binding]; other site 485918013962 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 485918013963 active site 485918013964 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918013965 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 485918013966 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 485918013967 active site 485918013968 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 485918013969 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 485918013970 substrate binding site [chemical binding]; other site 485918013971 oxyanion hole (OAH) forming residues; other site 485918013972 trimer interface [polypeptide binding]; other site 485918013973 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 485918013974 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 485918013975 substrate binding site [chemical binding]; other site 485918013976 oxyanion hole (OAH) forming residues; other site 485918013977 trimer interface [polypeptide binding]; other site 485918013978 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 485918013979 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 485918013980 dimer interface [polypeptide binding]; other site 485918013981 active site 485918013982 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 485918013983 putative NADP binding site [chemical binding]; other site 485918013984 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 485918013985 active site 485918013986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918013987 S-adenosylmethionine binding site [chemical binding]; other site 485918013988 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 485918013989 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 485918013990 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 485918013991 active site 485918013992 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 485918013993 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 485918013994 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 485918013995 putative NADP binding site [chemical binding]; other site 485918013996 active site 485918013997 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 485918013998 Methyltransferase domain; Region: Methyltransf_23; pfam13489 485918013999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918014000 S-adenosylmethionine binding site [chemical binding]; other site 485918014001 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 485918014002 polyketide synthase; Region: polyketide_synthase; cd08251 485918014003 Enoylreductase; Region: PKS_ER; smart00829 485918014004 putative NAD(P) binding site [chemical binding]; other site 485918014005 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 485918014006 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 485918014007 active site 485918014008 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 485918014009 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 485918014010 putative NADP binding site [chemical binding]; other site 485918014011 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 485918014012 active site 485918014013 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 485918014014 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 485918014015 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 485918014016 active site 485918014017 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 485918014018 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 485918014019 acyl-CoA synthetase; Validated; Region: PRK05850 485918014020 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 485918014021 acyl-activating enzyme (AAE) consensus motif; other site 485918014022 active site 485918014023 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918014024 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 485918014025 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 485918014026 active site 485918014027 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 485918014028 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 485918014029 KR domain; Region: KR; pfam08659 485918014030 putative NADP binding site [chemical binding]; other site 485918014031 active site 485918014032 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 485918014033 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 485918014034 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 485918014035 active site 485918014036 Chorismate lyase; Region: Chor_lyase; cl01230 485918014037 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 485918014038 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 485918014039 Cytochrome P450; Region: p450; cl12078 485918014040 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 485918014041 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 485918014042 dimer interface [polypeptide binding]; other site 485918014043 active site 485918014044 acyl carrier protein; Validated; Region: PRK07117 485918014045 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 485918014046 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 485918014047 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 485918014048 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 485918014049 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 485918014050 phosphate binding site [ion binding]; other site 485918014051 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 485918014052 transcriptional activator RfaH; Region: RfaH; TIGR01955 485918014053 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 485918014054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918014055 putative substrate translocation pore; other site 485918014056 Uncharacterized conserved protein [Function unknown]; Region: COG4278 485918014057 TIGR04222 domain; Region: near_uncomplex 485918014058 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 485918014059 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 485918014060 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 485918014061 Sulfatase; Region: Sulfatase; pfam00884 485918014062 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918014063 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918014064 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918014065 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918014066 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918014067 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918014068 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 485918014069 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 485918014070 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 485918014071 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 485918014072 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 485918014073 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918014074 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918014075 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 485918014076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918014077 putative substrate translocation pore; other site 485918014078 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 485918014079 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 485918014080 Walker A/P-loop; other site 485918014081 ATP binding site [chemical binding]; other site 485918014082 Q-loop/lid; other site 485918014083 ABC transporter signature motif; other site 485918014084 Walker B; other site 485918014085 D-loop; other site 485918014086 H-loop/switch region; other site 485918014087 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 485918014088 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 485918014089 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 485918014090 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 485918014091 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 485918014092 N-terminal plug; other site 485918014093 ligand-binding site [chemical binding]; other site 485918014094 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 485918014095 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 485918014096 active site 485918014097 zinc binding site [ion binding]; other site 485918014098 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 485918014099 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 485918014100 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 485918014101 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 485918014102 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 485918014103 putative active site [active] 485918014104 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 485918014105 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918014106 Walker A/P-loop; other site 485918014107 ATP binding site [chemical binding]; other site 485918014108 Q-loop/lid; other site 485918014109 ABC transporter signature motif; other site 485918014110 Walker B; other site 485918014111 D-loop; other site 485918014112 H-loop/switch region; other site 485918014113 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 485918014114 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 485918014115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918014116 putative substrate translocation pore; other site 485918014117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918014118 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 485918014119 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 485918014120 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918014121 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 485918014122 putative Zn2+ binding site [ion binding]; other site 485918014123 putative DNA binding site [nucleotide binding]; other site 485918014124 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cl00365 485918014125 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 485918014126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918014127 active site 485918014128 phosphorylation site [posttranslational modification] 485918014129 intermolecular recognition site; other site 485918014130 dimerization interface [polypeptide binding]; other site 485918014131 LytTr DNA-binding domain; Region: LytTR; pfam04397 485918014132 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 485918014133 Histidine kinase; Region: His_kinase; pfam06580 485918014134 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 485918014135 Phosphotransferase enzyme family; Region: APH; pfam01636 485918014136 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 485918014137 active site 485918014138 ATP binding site [chemical binding]; other site 485918014139 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 485918014140 substrate binding site [chemical binding]; other site 485918014141 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 485918014142 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 485918014143 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918014144 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918014145 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918014146 DNA binding residues [nucleotide binding] 485918014147 FecR protein; Region: FecR; pfam04773 485918014148 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918014149 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918014150 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918014151 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918014152 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918014153 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918014154 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918014155 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918014156 catalytic residues [active] 485918014157 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 485918014158 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918014159 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 485918014160 active site flap/lid [active] 485918014161 nucleophilic elbow; other site 485918014162 catalytic triad [active] 485918014163 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 485918014164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 485918014165 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918014166 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918014167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918014168 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 485918014169 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 485918014170 nudix motif; other site 485918014171 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 485918014172 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 485918014173 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 485918014174 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918014175 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918014176 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 485918014177 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 485918014178 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 485918014179 catalytic motif [active] 485918014180 Catalytic residue [active] 485918014181 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918014182 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 485918014183 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918014184 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 485918014185 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 485918014186 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 485918014187 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 485918014188 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 485918014189 DNA binding residues [nucleotide binding] 485918014190 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 485918014191 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 485918014192 Substrate binding site [chemical binding]; other site 485918014193 Leucine rich repeat; Region: LRR_8; pfam13855 485918014194 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 485918014195 Leucine-rich repeats; other site 485918014196 Substrate binding site [chemical binding]; other site 485918014197 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 485918014198 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 485918014199 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 485918014200 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 485918014201 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 485918014202 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 485918014203 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918014204 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 485918014205 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 485918014206 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 485918014207 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 485918014208 dimer interface [polypeptide binding]; other site 485918014209 active site 485918014210 heme binding site [chemical binding]; other site 485918014211 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 485918014212 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918014213 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918014214 short chain dehydrogenase; Provisional; Region: PRK12828 485918014215 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 485918014216 NADP binding site [chemical binding]; other site 485918014217 substrate binding site [chemical binding]; other site 485918014218 active site 485918014219 Cupin domain; Region: Cupin_2; pfam07883 485918014220 Histidine kinase; Region: His_kinase; pfam06580 485918014221 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918014222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918014223 active site 485918014224 phosphorylation site [posttranslational modification] 485918014225 intermolecular recognition site; other site 485918014226 dimerization interface [polypeptide binding]; other site 485918014227 LytTr DNA-binding domain; Region: LytTR; smart00850 485918014228 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 485918014229 Cupin domain; Region: Cupin_2; cl17218 485918014230 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918014231 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918014232 oxidoreductase; Provisional; Region: PRK06196 485918014233 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 485918014234 putative NAD(P) binding site [chemical binding]; other site 485918014235 active site 485918014236 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918014237 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918014238 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 485918014239 Two component regulator propeller; Region: Reg_prop; pfam07494 485918014240 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 485918014241 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918014242 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918014243 dimer interface [polypeptide binding]; other site 485918014244 phosphorylation site [posttranslational modification] 485918014245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918014246 ATP binding site [chemical binding]; other site 485918014247 Mg2+ binding site [ion binding]; other site 485918014248 G-X-G motif; other site 485918014249 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 485918014250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918014251 active site 485918014252 phosphorylation site [posttranslational modification] 485918014253 intermolecular recognition site; other site 485918014254 dimerization interface [polypeptide binding]; other site 485918014255 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918014256 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918014257 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 485918014258 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 485918014259 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 485918014260 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918014261 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918014262 SusD family; Region: SusD; pfam07980 485918014263 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918014264 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918014265 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918014266 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918014267 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 485918014268 active site 485918014269 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 485918014270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918014271 putative substrate translocation pore; other site 485918014272 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 485918014273 dimerization interface [polypeptide binding]; other site 485918014274 putative active cleft [active] 485918014275 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918014276 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918014277 ligand binding site [chemical binding]; other site 485918014278 flexible hinge region; other site 485918014279 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918014280 TAP-like protein; Region: Abhydrolase_4; pfam08386 485918014281 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 485918014282 homotrimer interaction site [polypeptide binding]; other site 485918014283 putative active site [active] 485918014284 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918014285 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918014286 ligand binding site [chemical binding]; other site 485918014287 short chain dehydrogenase; Provisional; Region: PRK08263 485918014288 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918014289 NADP binding site [chemical binding]; other site 485918014290 active site 485918014291 steroid binding site; other site 485918014292 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918014293 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918014294 FOG: CBS domain [General function prediction only]; Region: COG0517 485918014295 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 485918014296 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 485918014297 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 485918014298 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 485918014299 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 485918014300 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 485918014301 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 485918014302 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 485918014303 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 485918014304 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 485918014305 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 485918014306 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 485918014307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 485918014308 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 485918014309 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 485918014310 dimer interface [polypeptide binding]; other site 485918014311 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 485918014312 active site 485918014313 Fe binding site [ion binding]; other site 485918014314 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 485918014315 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918014316 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918014317 catalytic residues [active] 485918014318 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918014319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918014320 hypothetical protein; Provisional; Region: PRK07236 485918014321 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 485918014322 Fatty acid desaturase; Region: FA_desaturase; pfam00487 485918014323 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 485918014324 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 485918014325 active site 485918014326 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 485918014327 catalytic tetrad [active] 485918014328 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 485918014329 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 485918014330 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 485918014331 putative catalytic residues [active] 485918014332 nucleotide binding site [chemical binding]; other site 485918014333 aspartate binding site [chemical binding]; other site 485918014334 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 485918014335 dimer interface [polypeptide binding]; other site 485918014336 putative threonine allosteric regulatory site; other site 485918014337 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 485918014338 putative threonine allosteric regulatory site; other site 485918014339 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 485918014340 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 485918014341 homoserine kinase; Provisional; Region: PRK01212 485918014342 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 485918014343 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 485918014344 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 485918014345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918014346 catalytic residue [active] 485918014347 TPR repeat; Region: TPR_11; pfam13414 485918014348 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918014349 binding surface 485918014350 TPR motif; other site 485918014351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918014352 binding surface 485918014353 TPR motif; other site 485918014354 TPR repeat; Region: TPR_11; pfam13414 485918014355 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 485918014356 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 485918014357 substrate binding site [chemical binding]; other site 485918014358 hexamer interface [polypeptide binding]; other site 485918014359 metal binding site [ion binding]; metal-binding site 485918014360 Response regulator receiver domain; Region: Response_reg; pfam00072 485918014361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918014362 active site 485918014363 phosphorylation site [posttranslational modification] 485918014364 intermolecular recognition site; other site 485918014365 dimerization interface [polypeptide binding]; other site 485918014366 PAS domain S-box; Region: sensory_box; TIGR00229 485918014367 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 485918014368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918014369 ATP binding site [chemical binding]; other site 485918014370 Mg2+ binding site [ion binding]; other site 485918014371 G-X-G motif; other site 485918014372 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 485918014373 PhoH-like protein; Region: PhoH; pfam02562 485918014374 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 485918014375 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 485918014376 dimer interface [polypeptide binding]; other site 485918014377 substrate binding site [chemical binding]; other site 485918014378 metal binding sites [ion binding]; metal-binding site 485918014379 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 485918014380 NlpC/P60 family; Region: NLPC_P60; pfam00877 485918014381 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 485918014382 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918014383 DNA binding residues [nucleotide binding] 485918014384 Putative zinc-finger; Region: zf-HC2; pfam13490 485918014385 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918014386 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 485918014387 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918014388 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918014389 DNA binding residues [nucleotide binding] 485918014390 Putative zinc-finger; Region: zf-HC2; pfam13490 485918014391 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 485918014392 DNA gyrase subunit A; Validated; Region: PRK05560 485918014393 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 485918014394 CAP-like domain; other site 485918014395 active site 485918014396 primary dimer interface [polypeptide binding]; other site 485918014397 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 485918014398 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 485918014399 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 485918014400 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 485918014401 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 485918014402 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 485918014403 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 485918014404 NAD-dependent deacetylase; Provisional; Region: PRK00481 485918014405 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 485918014406 NAD+ binding site [chemical binding]; other site 485918014407 substrate binding site [chemical binding]; other site 485918014408 Zn binding site [ion binding]; other site 485918014409 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 485918014410 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 485918014411 active site 485918014412 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 485918014413 EVE domain; Region: EVE; pfam01878 485918014414 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 485918014415 Cysteine-rich domain; Region: CCG; pfam02754 485918014416 Cysteine-rich domain; Region: CCG; pfam02754 485918014417 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 485918014418 homopentamer interface [polypeptide binding]; other site 485918014419 active site 485918014420 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 485918014421 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 485918014422 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 485918014423 tetramer interface [polypeptide binding]; other site 485918014424 TPP-binding site [chemical binding]; other site 485918014425 heterodimer interface [polypeptide binding]; other site 485918014426 phosphorylation loop region [posttranslational modification] 485918014427 recombination protein F; Reviewed; Region: recF; PRK00064 485918014428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918014429 Walker A/P-loop; other site 485918014430 ATP binding site [chemical binding]; other site 485918014431 Q-loop/lid; other site 485918014432 ABC transporter signature motif; other site 485918014433 Walker B; other site 485918014434 D-loop; other site 485918014435 H-loop/switch region; other site 485918014436 Protein of unknown function (DUF721); Region: DUF721; pfam05258 485918014437 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 485918014438 putative active site [active] 485918014439 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 485918014440 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 485918014441 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 485918014442 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918014443 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918014444 DNA binding residues [nucleotide binding] 485918014445 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 485918014446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 485918014447 dimer interface [polypeptide binding]; other site 485918014448 conserved gate region; other site 485918014449 putative PBP binding loops; other site 485918014450 ABC-ATPase subunit interface; other site 485918014451 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 485918014452 dihydropteroate synthase; Region: DHPS; TIGR01496 485918014453 substrate binding pocket [chemical binding]; other site 485918014454 dimer interface [polypeptide binding]; other site 485918014455 inhibitor binding site; inhibition site 485918014456 Uncharacterized conserved protein [Function unknown]; Region: COG1624 485918014457 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 485918014458 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 485918014459 DHH family; Region: DHH; pfam01368 485918014460 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 485918014461 active site 485918014462 multimer interface [polypeptide binding]; other site 485918014463 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 485918014464 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 485918014465 active site 485918014466 Int/Topo IB signature motif; other site 485918014467 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 485918014468 active site 485918014469 catalytic site [active] 485918014470 putative metal binding site [ion binding]; other site 485918014471 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 485918014472 Histidine kinase; Region: HisKA_3; pfam07730 485918014473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918014474 ATP binding site [chemical binding]; other site 485918014475 Mg2+ binding site [ion binding]; other site 485918014476 G-X-G motif; other site 485918014477 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918014478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918014479 active site 485918014480 phosphorylation site [posttranslational modification] 485918014481 intermolecular recognition site; other site 485918014482 dimerization interface [polypeptide binding]; other site 485918014483 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918014484 DNA binding residues [nucleotide binding] 485918014485 dimerization interface [polypeptide binding]; other site 485918014486 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 485918014487 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 485918014488 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 485918014489 Na binding site [ion binding]; other site 485918014490 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 485918014491 Protein of unknown function, DUF486; Region: DUF486; cl01236 485918014492 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918014493 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918014494 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918014495 DNA binding residues [nucleotide binding] 485918014496 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918014497 FecR protein; Region: FecR; pfam04773 485918014498 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918014499 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918014500 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918014501 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918014502 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 485918014503 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 485918014504 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 485918014505 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 485918014506 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 485918014507 active site 485918014508 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 485918014509 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 485918014510 catalytic triad [active] 485918014511 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 485918014512 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 485918014513 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 485918014514 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 485918014515 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 485918014516 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 485918014517 Glutamate binding site [chemical binding]; other site 485918014518 NAD binding site [chemical binding]; other site 485918014519 catalytic residues [active] 485918014520 peptide chain release factor 2; Validated; Region: prfB; PRK00578 485918014521 This domain is found in peptide chain release factors; Region: PCRF; smart00937 485918014522 RF-1 domain; Region: RF-1; pfam00472 485918014523 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 485918014524 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 485918014525 active site 485918014526 dimer interface [polypeptide binding]; other site 485918014527 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 485918014528 dimer interface [polypeptide binding]; other site 485918014529 active site 485918014530 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 485918014531 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 485918014532 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 485918014533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918014534 Walker A/P-loop; other site 485918014535 ATP binding site [chemical binding]; other site 485918014536 Q-loop/lid; other site 485918014537 ABC transporter signature motif; other site 485918014538 Walker B; other site 485918014539 D-loop; other site 485918014540 H-loop/switch region; other site 485918014541 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 485918014542 ATP binding site [chemical binding]; other site 485918014543 active site 485918014544 substrate binding site [chemical binding]; other site 485918014545 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 485918014546 active site 485918014547 catalytic site [active] 485918014548 substrate binding site [chemical binding]; other site 485918014549 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 485918014550 GIY-YIG motif/motif A; other site 485918014551 active site 485918014552 catalytic site [active] 485918014553 putative DNA binding site [nucleotide binding]; other site 485918014554 metal binding site [ion binding]; metal-binding site 485918014555 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 485918014556 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918014557 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918014558 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 485918014559 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 485918014560 FMN binding site [chemical binding]; other site 485918014561 active site 485918014562 substrate binding site [chemical binding]; other site 485918014563 catalytic residue [active] 485918014564 Glucuronate isomerase; Region: UxaC; pfam02614 485918014565 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 485918014566 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 485918014567 galactarate dehydratase; Region: galactar-dH20; TIGR03248 485918014568 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 485918014569 altronate oxidoreductase; Provisional; Region: PRK03643 485918014570 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 485918014571 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 485918014572 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 485918014573 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 485918014574 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 485918014575 active site 485918014576 catalytic triad [active] 485918014577 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 485918014578 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 485918014579 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918014580 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918014581 SusD family; Region: SusD; pfam07980 485918014582 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918014583 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918014584 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918014585 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 485918014586 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 485918014587 active site 485918014588 Transcriptional regulators [Transcription]; Region: PurR; COG1609 485918014589 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 485918014590 DNA binding site [nucleotide binding] 485918014591 domain linker motif; other site 485918014592 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 485918014593 ligand binding site [chemical binding]; other site 485918014594 dimerization interface [polypeptide binding]; other site 485918014595 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 485918014596 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 485918014597 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 485918014598 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 485918014599 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 485918014600 conserved cys residue [active] 485918014601 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918014602 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918014603 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 485918014604 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 485918014605 putative NAD(P) binding site [chemical binding]; other site 485918014606 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918014607 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918014608 short chain dehydrogenase; Provisional; Region: PRK06172 485918014609 classical (c) SDRs; Region: SDR_c; cd05233 485918014610 NAD(P) binding site [chemical binding]; other site 485918014611 active site 485918014612 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663 485918014613 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918014614 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918014615 SusD family; Region: SusD; pfam07980 485918014616 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918014617 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918014618 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918014619 FecR protein; Region: FecR; pfam04773 485918014620 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918014621 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918014622 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918014623 DNA binding residues [nucleotide binding] 485918014624 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 485918014625 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 485918014626 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 485918014627 Beta-lactamase; Region: Beta-lactamase; pfam00144 485918014628 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 485918014629 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 485918014630 Peptidase family M1; Region: Peptidase_M1; pfam01433 485918014631 Zn binding site [ion binding]; other site 485918014632 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 485918014633 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 485918014634 Ligand Binding Site [chemical binding]; other site 485918014635 PAS fold; Region: PAS_4; pfam08448 485918014636 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918014637 putative active site [active] 485918014638 heme pocket [chemical binding]; other site 485918014639 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918014640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918014641 phosphorylation site [posttranslational modification] 485918014642 dimer interface [polypeptide binding]; other site 485918014643 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918014644 SusD family; Region: SusD; pfam07980 485918014645 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918014646 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918014647 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918014648 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918014649 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 485918014650 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 485918014651 active site 485918014652 metal binding site [ion binding]; metal-binding site 485918014653 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 485918014654 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 485918014655 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 485918014656 LytTr DNA-binding domain; Region: LytTR; smart00850 485918014657 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 485918014658 MarR family; Region: MarR_2; pfam12802 485918014659 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 485918014660 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 485918014661 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 485918014662 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 485918014663 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918014664 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918014665 dimer interface [polypeptide binding]; other site 485918014666 phosphorylation site [posttranslational modification] 485918014667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918014668 ATP binding site [chemical binding]; other site 485918014669 Mg2+ binding site [ion binding]; other site 485918014670 G-X-G motif; other site 485918014671 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 485918014672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918014673 active site 485918014674 phosphorylation site [posttranslational modification] 485918014675 intermolecular recognition site; other site 485918014676 dimerization interface [polypeptide binding]; other site 485918014677 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918014678 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918014679 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 485918014680 FOG: WD40 repeat [General function prediction only]; Region: COG2319 485918014681 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 485918014682 dimer interface [polypeptide binding]; other site 485918014683 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 485918014684 PA14 domain; Region: PA14; cl08459 485918014685 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 485918014686 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 485918014687 putative active site [active] 485918014688 putative catalytic site [active] 485918014689 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918014690 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918014691 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918014692 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 485918014693 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918014694 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918014695 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918014696 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 485918014697 putative sugar binding site [chemical binding]; other site 485918014698 catalytic residues [active] 485918014699 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 485918014700 aromatic chitin/cellulose binding site residues [chemical binding]; other site 485918014701 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 485918014702 aromatic chitin/cellulose binding site residues [chemical binding]; other site 485918014703 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918014704 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 485918014705 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918014706 PAS domain S-box; Region: sensory_box; TIGR00229 485918014707 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918014708 putative active site [active] 485918014709 heme pocket [chemical binding]; other site 485918014710 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918014711 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918014712 dimer interface [polypeptide binding]; other site 485918014713 phosphorylation site [posttranslational modification] 485918014714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918014715 ATP binding site [chemical binding]; other site 485918014716 Mg2+ binding site [ion binding]; other site 485918014717 G-X-G motif; other site 485918014718 Response regulator receiver domain; Region: Response_reg; pfam00072 485918014719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918014720 active site 485918014721 phosphorylation site [posttranslational modification] 485918014722 intermolecular recognition site; other site 485918014723 dimerization interface [polypeptide binding]; other site 485918014724 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918014725 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 485918014726 ligand binding site [chemical binding]; other site 485918014727 flexible hinge region; other site 485918014728 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 485918014729 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918014730 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918014731 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918014732 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918014733 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918014734 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918014735 FecR protein; Region: FecR; pfam04773 485918014736 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918014737 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918014738 Response regulator receiver domain; Region: Response_reg; pfam00072 485918014739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918014740 active site 485918014741 phosphorylation site [posttranslational modification] 485918014742 intermolecular recognition site; other site 485918014743 dimerization interface [polypeptide binding]; other site 485918014744 CHASE3 domain; Region: CHASE3; pfam05227 485918014745 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 485918014746 dimerization interface [polypeptide binding]; other site 485918014747 GAF domain; Region: GAF_2; pfam13185 485918014748 GAF domain; Region: GAF; pfam01590 485918014749 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918014750 dimer interface [polypeptide binding]; other site 485918014751 phosphorylation site [posttranslational modification] 485918014752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918014753 ATP binding site [chemical binding]; other site 485918014754 Mg2+ binding site [ion binding]; other site 485918014755 G-X-G motif; other site 485918014756 Response regulator receiver domain; Region: Response_reg; pfam00072 485918014757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918014758 active site 485918014759 phosphorylation site [posttranslational modification] 485918014760 intermolecular recognition site; other site 485918014761 dimerization interface [polypeptide binding]; other site 485918014762 Response regulator receiver domain; Region: Response_reg; pfam00072 485918014763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918014764 active site 485918014765 phosphorylation site [posttranslational modification] 485918014766 intermolecular recognition site; other site 485918014767 Response regulator receiver domain; Region: Response_reg; pfam00072 485918014768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918014769 active site 485918014770 phosphorylation site [posttranslational modification] 485918014771 intermolecular recognition site; other site 485918014772 dimerization interface [polypeptide binding]; other site 485918014773 Peptidase of plants and bacteria; Region: BSP; pfam04450 485918014774 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 485918014775 RmuC family; Region: RmuC; pfam02646 485918014776 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 485918014777 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 485918014778 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 485918014779 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 485918014780 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 485918014781 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 485918014782 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 485918014783 GAF domain; Region: GAF; pfam01590 485918014784 PAS domain S-box; Region: sensory_box; TIGR00229 485918014785 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918014786 putative active site [active] 485918014787 heme pocket [chemical binding]; other site 485918014788 PAS domain S-box; Region: sensory_box; TIGR00229 485918014789 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918014790 putative active site [active] 485918014791 heme pocket [chemical binding]; other site 485918014792 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 485918014793 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918014794 putative active site [active] 485918014795 heme pocket [chemical binding]; other site 485918014796 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918014797 dimer interface [polypeptide binding]; other site 485918014798 phosphorylation site [posttranslational modification] 485918014799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918014800 ATP binding site [chemical binding]; other site 485918014801 Mg2+ binding site [ion binding]; other site 485918014802 G-X-G motif; other site 485918014803 Response regulator receiver domain; Region: Response_reg; pfam00072 485918014804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918014805 active site 485918014806 phosphorylation site [posttranslational modification] 485918014807 intermolecular recognition site; other site 485918014808 dimerization interface [polypeptide binding]; other site 485918014809 Response regulator receiver domain; Region: Response_reg; pfam00072 485918014810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918014811 active site 485918014812 phosphorylation site [posttranslational modification] 485918014813 intermolecular recognition site; other site 485918014814 dimerization interface [polypeptide binding]; other site 485918014815 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918014816 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918014817 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918014818 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918014819 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 485918014820 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 485918014821 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918014822 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 485918014823 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 485918014824 N-terminal plug; other site 485918014825 ligand-binding site [chemical binding]; other site 485918014826 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 485918014827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918014828 active site 485918014829 phosphorylation site [posttranslational modification] 485918014830 intermolecular recognition site; other site 485918014831 dimerization interface [polypeptide binding]; other site 485918014832 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 485918014833 DNA binding site [nucleotide binding] 485918014834 Uncharacterized conserved protein [Function unknown]; Region: COG2308 485918014835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 485918014836 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 485918014837 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 485918014838 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 485918014839 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 485918014840 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 485918014841 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 485918014842 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 485918014843 dimer interface [polypeptide binding]; other site 485918014844 NADP binding site [chemical binding]; other site 485918014845 catalytic residues [active] 485918014846 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 485918014847 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 485918014848 inhibitor site; inhibition site 485918014849 active site 485918014850 dimer interface [polypeptide binding]; other site 485918014851 catalytic residue [active] 485918014852 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918014853 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918014854 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 485918014855 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 485918014856 active site 485918014857 catalytic tetrad [active] 485918014858 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 485918014859 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 485918014860 EamA-like transporter family; Region: EamA; pfam00892 485918014861 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 485918014862 CGNR zinc finger; Region: zf-CGNR; pfam11706 485918014863 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 485918014864 active site 485918014865 catalytic residues [active] 485918014866 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 485918014867 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 485918014868 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 485918014869 active site residue [active] 485918014870 Response regulator receiver domain; Region: Response_reg; pfam00072 485918014871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918014872 active site 485918014873 phosphorylation site [posttranslational modification] 485918014874 intermolecular recognition site; other site 485918014875 dimerization interface [polypeptide binding]; other site 485918014876 Histidine kinase; Region: His_kinase; pfam06580 485918014877 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918014878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918014879 active site 485918014880 phosphorylation site [posttranslational modification] 485918014881 intermolecular recognition site; other site 485918014882 dimerization interface [polypeptide binding]; other site 485918014883 LytTr DNA-binding domain; Region: LytTR; smart00850 485918014884 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918014885 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 485918014886 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918014887 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 485918014888 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 485918014889 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 485918014890 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 485918014891 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 485918014892 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 485918014893 putative ADP-binding pocket [chemical binding]; other site 485918014894 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 485918014895 active site 485918014896 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918014897 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918014898 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918014899 Glycosyl hydrolase family 47; Region: Glyco_hydro_47; pfam01532 485918014900 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918014901 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 485918014902 SPFH domain / Band 7 family; Region: Band_7; pfam01145 485918014903 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 485918014904 Uncharacterized conserved protein [Function unknown]; Region: COG2454 485918014905 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 485918014906 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 485918014907 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918014908 NAD(P) binding site [chemical binding]; other site 485918014909 active site 485918014910 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918014911 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918014912 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 485918014913 beta-carotene hydroxylase; Region: PLN02601 485918014914 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 485918014915 active site lid residues [active] 485918014916 substrate binding pocket [chemical binding]; other site 485918014917 catalytic residues [active] 485918014918 substrate-Mg2+ binding site; other site 485918014919 aspartate-rich region 1; other site 485918014920 aspartate-rich region 2; other site 485918014921 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 485918014922 phytoene desaturase; Region: crtI_fam; TIGR02734 485918014923 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 485918014924 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 485918014925 DNA binding residues [nucleotide binding] 485918014926 B12 binding domain; Region: B12-binding_2; pfam02607 485918014927 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 485918014928 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 485918014929 NAD(P) binding site [chemical binding]; other site 485918014930 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 485918014931 putative hydrophobic ligand binding site [chemical binding]; other site 485918014932 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 485918014933 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918014934 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918014935 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 485918014936 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 485918014937 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 485918014938 putative NAD(P) binding site [chemical binding]; other site 485918014939 homodimer interface [polypeptide binding]; other site 485918014940 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 485918014941 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 485918014942 putative NAD(P) binding site [chemical binding]; other site 485918014943 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918014944 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918014945 ligand binding site [chemical binding]; other site 485918014946 flexible hinge region; other site 485918014947 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 485918014948 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 485918014949 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 485918014950 Predicted membrane protein [Function unknown]; Region: COG3503 485918014951 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918014952 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918014953 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918014954 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 485918014955 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918014956 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918014957 ligand binding site [chemical binding]; other site 485918014958 flexible hinge region; other site 485918014959 MarR family; Region: MarR_2; cl17246 485918014960 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 485918014961 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 485918014962 GDP-binding site [chemical binding]; other site 485918014963 ACT binding site; other site 485918014964 IMP binding site; other site 485918014965 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 485918014966 trehalose synthase; Region: treS_nterm; TIGR02456 485918014967 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 485918014968 active site 485918014969 catalytic site [active] 485918014970 putative transporter; Provisional; Region: PRK10484 485918014971 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 485918014972 Na binding site [ion binding]; other site 485918014973 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 485918014974 DNA-binding site [nucleotide binding]; DNA binding site 485918014975 Transcriptional regulators [Transcription]; Region: PurR; COG1609 485918014976 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 485918014977 putative dimerization interface [polypeptide binding]; other site 485918014978 putative ligand binding site [chemical binding]; other site 485918014979 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 485918014980 Melibiase; Region: Melibiase; pfam02065 485918014981 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 485918014982 alpha-galactosidase; Region: PLN02229 485918014983 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918014984 SusD family; Region: SusD; pfam07980 485918014985 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918014986 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918014987 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918014988 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918014989 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918014990 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918014991 ligand binding site [chemical binding]; other site 485918014992 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 485918014993 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 485918014994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918014995 short chain dehydrogenase; Provisional; Region: PRK12939 485918014996 NAD(P) binding site [chemical binding]; other site 485918014997 active site 485918014998 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 485918014999 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 485918015000 active site 485918015001 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 485918015002 HD domain; Region: HD_3; pfam13023 485918015003 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 485918015004 AAA domain; Region: AAA_17; pfam13207 485918015005 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 485918015006 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 485918015007 Beta/Gamma crystallin; Region: Crystall; cl02528 485918015008 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 485918015009 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 485918015010 putative sugar binding sites [chemical binding]; other site 485918015011 Q-X-W motif; other site 485918015012 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918015013 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918015014 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918015016 NAD(P) binding site [chemical binding]; other site 485918015017 active site 485918015018 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 485918015019 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 485918015020 PA/protease or protease-like domain interface [polypeptide binding]; other site 485918015021 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 485918015022 Peptidase family M28; Region: Peptidase_M28; pfam04389 485918015023 metal binding site [ion binding]; metal-binding site 485918015024 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 485918015025 homotrimer interaction site [polypeptide binding]; other site 485918015026 putative active site [active] 485918015027 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 485918015028 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918015029 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918015030 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 485918015031 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 485918015032 putative ligand binding site [chemical binding]; other site 485918015033 putative NAD binding site [chemical binding]; other site 485918015034 catalytic site [active] 485918015035 YceI-like domain; Region: YceI; pfam04264 485918015036 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 485918015037 phosphate binding site [ion binding]; other site 485918015038 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 485918015039 tetramer interface [polypeptide binding]; other site 485918015040 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 485918015041 active site 485918015042 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918015043 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015044 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 485918015045 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 485918015046 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 485918015047 putative sugar binding sites [chemical binding]; other site 485918015048 Q-X-W motif; other site 485918015049 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918015050 FtsX-like permease family; Region: FtsX; pfam02687 485918015051 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 485918015052 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 485918015053 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918015054 FtsX-like permease family; Region: FtsX; pfam02687 485918015055 Fatty acid desaturase; Region: FA_desaturase; pfam00487 485918015056 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 485918015057 putative di-iron ligands [ion binding]; other site 485918015058 Fatty acid desaturase; Region: FA_desaturase; pfam00487 485918015059 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 485918015060 putative di-iron ligands [ion binding]; other site 485918015061 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918015062 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 485918015063 Histidine kinase; Region: HisKA_2; pfam07568 485918015064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918015065 ATP binding site [chemical binding]; other site 485918015066 Mg2+ binding site [ion binding]; other site 485918015067 G-X-G motif; other site 485918015068 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918015069 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 485918015070 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918015071 Epoxide hydrolase N terminus; Region: EHN; pfam06441 485918015072 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918015073 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918015074 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 485918015075 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 485918015076 N-terminal plug; other site 485918015077 ligand-binding site [chemical binding]; other site 485918015078 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 485918015079 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 485918015080 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 485918015081 catalytic residue [active] 485918015082 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 485918015083 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 485918015084 metal-binding site [ion binding] 485918015085 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 485918015086 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918015087 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918015088 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918015089 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 485918015090 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 485918015091 active site 485918015092 catalytic tetrad [active] 485918015093 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 485918015094 putative dimer interface [polypeptide binding]; other site 485918015095 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918015096 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 485918015097 hypothetical protein; Validated; Region: PRK05868 485918015098 hypothetical protein; Provisional; Region: PRK07236 485918015099 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 485918015100 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918015101 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015102 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 485918015103 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 485918015104 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 485918015105 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 485918015106 putative NAD(P) binding site [chemical binding]; other site 485918015107 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918015108 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015109 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 485918015110 active site 485918015111 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 485918015112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918015113 NAD(P) binding site [chemical binding]; other site 485918015114 active site 485918015115 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918015116 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015117 NLI interacting factor-like phosphatase; Region: NIF; pfam03031 485918015118 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 485918015119 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918015120 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015121 AIR carboxylase; Region: AIRC; pfam00731 485918015122 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 485918015123 ATP-grasp domain; Region: ATP-grasp; pfam02222 485918015124 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 485918015125 Leucine-rich repeats; other site 485918015126 Substrate binding site [chemical binding]; other site 485918015127 Leucine rich repeat; Region: LRR_8; pfam13855 485918015128 Leucine rich repeat; Region: LRR_8; pfam13855 485918015129 Leucine rich repeat; Region: LRR_8; pfam13855 485918015130 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 485918015131 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 485918015132 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 485918015133 salt bridge; other site 485918015134 non-specific DNA binding site [nucleotide binding]; other site 485918015135 sequence-specific DNA binding site [nucleotide binding]; other site 485918015136 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 485918015137 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 485918015138 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 485918015139 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 485918015140 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 485918015141 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 485918015142 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 485918015143 DNA binding site [nucleotide binding] 485918015144 active site 485918015145 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 485918015146 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918015147 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918015148 catalytic residues [active] 485918015149 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 485918015150 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 485918015151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918015152 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 485918015153 NAD(P) binding site [chemical binding]; other site 485918015154 active site 485918015155 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918015156 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015157 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 485918015158 classical (c) SDRs; Region: SDR_c; cd05233 485918015159 NAD(P) binding site [chemical binding]; other site 485918015160 active site 485918015161 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 485918015162 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918015163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918015164 active site 485918015165 phosphorylation site [posttranslational modification] 485918015166 intermolecular recognition site; other site 485918015167 dimerization interface [polypeptide binding]; other site 485918015168 LytTr DNA-binding domain; Region: LytTR; pfam04397 485918015169 Histidine kinase; Region: His_kinase; pfam06580 485918015170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918015171 ATP binding site [chemical binding]; other site 485918015172 Mg2+ binding site [ion binding]; other site 485918015173 G-X-G motif; other site 485918015174 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 485918015175 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13540 485918015176 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918015177 Walker A/P-loop; other site 485918015178 ATP binding site [chemical binding]; other site 485918015179 Q-loop/lid; other site 485918015180 ABC transporter signature motif; other site 485918015181 Walker B; other site 485918015182 D-loop; other site 485918015183 H-loop/switch region; other site 485918015184 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 485918015185 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 485918015186 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 485918015187 alpha-galactosidase; Region: PLN02808; cl17638 485918015188 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918015189 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015190 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 485918015191 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 485918015192 active site 485918015193 nucleotide binding site [chemical binding]; other site 485918015194 HIGH motif; other site 485918015195 KMSKS motif; other site 485918015196 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 485918015197 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 485918015198 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 485918015199 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918015200 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 485918015201 Sel1-like repeats; Region: SEL1; smart00671 485918015202 Sel1-like repeats; Region: SEL1; smart00671 485918015203 Sel1-like repeats; Region: SEL1; smart00671 485918015204 Sel1-like repeats; Region: SEL1; smart00671 485918015205 GAF domain; Region: GAF; pfam01590 485918015206 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 485918015207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918015208 ATP binding site [chemical binding]; other site 485918015209 Mg2+ binding site [ion binding]; other site 485918015210 G-X-G motif; other site 485918015211 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 485918015212 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 485918015213 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 485918015214 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918015215 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918015216 catalytic residues [active] 485918015217 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 485918015218 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 485918015219 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 485918015220 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 485918015221 binding surface 485918015222 TPR motif; other site 485918015223 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918015224 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 485918015225 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918015226 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 485918015227 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 485918015228 ligand binding site [chemical binding]; other site 485918015229 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 485918015230 Domain of unknown function DUF11; Region: DUF11; pfam01345 485918015231 conserved repeat domain; Region: B_ant_repeat; TIGR01451 485918015232 Domain of unknown function DUF11; Region: DUF11; cl17728 485918015233 Domain of unknown function DUF11; Region: DUF11; pfam01345 485918015234 Domain of unknown function DUF11; Region: DUF11; cl17728 485918015235 Domain of unknown function DUF11; Region: DUF11; cl17728 485918015236 Domain of unknown function DUF11; Region: DUF11; cl17728 485918015237 Domain of unknown function DUF11; Region: DUF11; cl17728 485918015238 Domain of unknown function DUF11; Region: DUF11; cl17728 485918015239 Domain of unknown function DUF11; Region: DUF11; cl17728 485918015240 Domain of unknown function DUF11; Region: DUF11; pfam01345 485918015241 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918015242 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918015243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918015244 active site 485918015245 phosphorylation site [posttranslational modification] 485918015246 intermolecular recognition site; other site 485918015247 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918015248 DNA binding residues [nucleotide binding] 485918015249 dimerization interface [polypeptide binding]; other site 485918015250 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 485918015251 salt bridge; other site 485918015252 non-specific DNA binding site [nucleotide binding]; other site 485918015253 sequence-specific DNA binding site [nucleotide binding]; other site 485918015254 Transcriptional regulators [Transcription]; Region: MarR; COG1846 485918015255 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 485918015256 putative DNA binding site [nucleotide binding]; other site 485918015257 putative Zn2+ binding site [ion binding]; other site 485918015258 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918015259 Coenzyme A binding pocket [chemical binding]; other site 485918015260 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918015261 Uncharacterized conserved protein [Function unknown]; Region: COG3268 485918015262 NAD(P) binding site [chemical binding]; other site 485918015263 active site 485918015264 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 485918015265 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 485918015266 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 485918015267 ApbE family; Region: ApbE; pfam02424 485918015268 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 485918015269 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918015270 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 485918015271 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 485918015272 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 485918015273 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 485918015274 active site 485918015275 catalytic site [active] 485918015276 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918015277 Coenzyme A binding pocket [chemical binding]; other site 485918015278 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 485918015279 Ligand Binding Site [chemical binding]; other site 485918015280 DoxX-like family; Region: DoxX_2; pfam13564 485918015281 Methyltransferase domain; Region: Methyltransf_23; pfam13489 485918015282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918015283 S-adenosylmethionine binding site [chemical binding]; other site 485918015284 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 485918015285 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 485918015286 active site 485918015287 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 485918015288 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 485918015289 apolar tunnel; other site 485918015290 heme binding site [chemical binding]; other site 485918015291 dimerization interface [polypeptide binding]; other site 485918015292 putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional; Region: PRK14486 485918015293 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 485918015294 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 485918015295 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 485918015296 Low-spin heme binding site [chemical binding]; other site 485918015297 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 485918015298 D-pathway; other site 485918015299 Putative water exit pathway; other site 485918015300 Binuclear center (active site) [active] 485918015301 K-pathway; other site 485918015302 Putative proton exit pathway; other site 485918015303 Rrf2 family protein; Region: rrf2_super; TIGR00738 485918015304 Transcriptional regulator; Region: Rrf2; pfam02082 485918015305 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 485918015306 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 485918015307 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 485918015308 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 485918015309 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 485918015310 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918015311 Coenzyme A binding pocket [chemical binding]; other site 485918015312 DinB superfamily; Region: DinB_2; pfam12867 485918015313 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 485918015314 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 485918015315 dimer interface [polypeptide binding]; other site 485918015316 ligand binding site [chemical binding]; other site 485918015317 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918015318 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015319 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015320 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 485918015321 Cupin domain; Region: Cupin_2; cl17218 485918015322 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918015323 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015324 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 485918015325 AAA domain; Region: AAA_33; pfam13671 485918015326 tRNAHis guanylyltransferase; Region: Thg1; pfam04446 485918015327 Uncharacterized conserved protein [Function unknown]; Region: COG4021 485918015328 Thg1 C terminal domain; Region: Thg1C; pfam14413 485918015329 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 485918015330 EF-hand domain pair; Region: EF_hand_5; pfam13499 485918015331 pseudo EF-hand loop; other site 485918015332 peptide binding pocket; other site 485918015333 Ca2+ binding site [ion binding]; other site 485918015334 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 485918015335 TAP42-like family; Region: TAP42; pfam04177 485918015336 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 485918015337 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918015338 Coenzyme A binding pocket [chemical binding]; other site 485918015339 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 485918015340 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 485918015341 active site 485918015342 Zn binding site [ion binding]; other site 485918015343 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 485918015344 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 485918015345 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918015346 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 485918015347 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 485918015348 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 485918015349 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 485918015350 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 485918015351 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 485918015352 active site 485918015353 metal binding site [ion binding]; metal-binding site 485918015354 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 485918015355 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 485918015356 active site 485918015357 catalytic site [active] 485918015358 substrate binding site [chemical binding]; other site 485918015359 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 485918015360 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 485918015361 FMN binding site [chemical binding]; other site 485918015362 active site 485918015363 catalytic residues [active] 485918015364 substrate binding site [chemical binding]; other site 485918015365 Domain of unknown function (DUF4366); Region: DUF4366; pfam14283 485918015366 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 485918015367 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 485918015368 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 485918015369 ATP binding site [chemical binding]; other site 485918015370 Mg++ binding site [ion binding]; other site 485918015371 motif III; other site 485918015372 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 485918015373 nucleotide binding region [chemical binding]; other site 485918015374 ATP-binding site [chemical binding]; other site 485918015375 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918015376 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918015377 H+ Antiporter protein; Region: 2A0121; TIGR00900 485918015378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918015379 putative substrate translocation pore; other site 485918015380 Isochorismatase family; Region: Isochorismatase; pfam00857 485918015381 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 485918015382 catalytic triad [active] 485918015383 conserved cis-peptide bond; other site 485918015384 Protein of unknown function, DUF481; Region: DUF481; cl01213 485918015385 Uncharacterized conserved protein [Function unknown]; Region: COG4850 485918015386 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 485918015387 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 485918015388 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 485918015389 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 485918015390 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918015391 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918015392 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 485918015393 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 485918015394 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918015395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918015396 active site 485918015397 phosphorylation site [posttranslational modification] 485918015398 intermolecular recognition site; other site 485918015399 dimerization interface [polypeptide binding]; other site 485918015400 LytTr DNA-binding domain; Region: LytTR; smart00850 485918015401 Histidine kinase; Region: His_kinase; pfam06580 485918015402 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 485918015403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918015404 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 485918015405 Walker A motif; other site 485918015406 ATP binding site [chemical binding]; other site 485918015407 Walker B motif; other site 485918015408 arginine finger; other site 485918015409 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918015410 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 485918015411 ABC1 family; Region: ABC1; cl17513 485918015412 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 485918015413 active site 485918015414 ATP binding site [chemical binding]; other site 485918015415 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 485918015416 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918015417 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918015418 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918015419 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918015420 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918015421 SusD family; Region: SusD; pfam07980 485918015422 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 485918015423 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 485918015424 putative hydrophobic ligand binding site [chemical binding]; other site 485918015425 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 485918015426 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 485918015427 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 485918015428 tandem repeat interface [polypeptide binding]; other site 485918015429 oligomer interface [polypeptide binding]; other site 485918015430 active site residues [active] 485918015431 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 485918015432 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 485918015433 tandem repeat interface [polypeptide binding]; other site 485918015434 oligomer interface [polypeptide binding]; other site 485918015435 active site residues [active] 485918015436 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 485918015437 catalytic center binding site [active] 485918015438 ATP binding site [chemical binding]; other site 485918015439 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 485918015440 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 485918015441 Substrate-binding site [chemical binding]; other site 485918015442 Substrate specificity [chemical binding]; other site 485918015443 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 485918015444 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 485918015445 tetramer interface [polypeptide binding]; other site 485918015446 heme binding pocket [chemical binding]; other site 485918015447 NADPH binding site [chemical binding]; other site 485918015448 flavoprotein, HI0933 family; Region: TIGR00275 485918015449 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 485918015450 MG2 domain; Region: A2M_N; pfam01835 485918015451 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 485918015452 active site flap/lid [active] 485918015453 nucleophilic elbow; other site 485918015454 catalytic triad [active] 485918015455 Predicted chitinase [General function prediction only]; Region: COG3179 485918015456 catalytic residue [active] 485918015457 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 485918015458 Histidine kinase; Region: HisKA_2; pfam07568 485918015459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918015460 ATP binding site [chemical binding]; other site 485918015461 Mg2+ binding site [ion binding]; other site 485918015462 G-X-G motif; other site 485918015463 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918015464 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918015465 binding surface 485918015466 TPR motif; other site 485918015467 SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755 485918015468 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 485918015469 dimerization interface [polypeptide binding]; other site 485918015470 metal binding site [ion binding]; metal-binding site 485918015471 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 485918015472 substrate binding site [chemical binding]; other site 485918015473 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 485918015474 nudix motif; other site 485918015475 Right handed beta helix region; Region: Beta_helix; pfam13229 485918015476 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 485918015477 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918015478 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 485918015479 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 485918015480 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 485918015481 Phage Tail Collar Domain; Region: Collar; pfam07484 485918015482 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 485918015483 Phage Tail Collar Domain; Region: Collar; pfam07484 485918015484 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 485918015485 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 485918015486 Sphingolipid Delta4-desaturase (DES); Region: Lipid_DES; pfam08557 485918015487 sphingolipid delta-4 desaturase; Region: PLN02579 485918015488 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 485918015489 putative di-iron ligands [ion binding]; other site 485918015490 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 485918015491 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 485918015492 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 485918015493 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 485918015494 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 485918015495 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 485918015496 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 485918015497 Methyltransferase domain; Region: Methyltransf_23; pfam13489 485918015498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918015499 S-adenosylmethionine binding site [chemical binding]; other site 485918015500 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 485918015501 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 485918015502 NADP binding site [chemical binding]; other site 485918015503 dimer interface [polypeptide binding]; other site 485918015504 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918015505 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918015506 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 485918015507 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 485918015508 ligand binding site [chemical binding]; other site 485918015509 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 485918015510 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 485918015511 ligand binding site [chemical binding]; other site 485918015512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 485918015513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 485918015514 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918015515 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918015516 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918015517 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 485918015518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918015519 S-adenosylmethionine binding site [chemical binding]; other site 485918015520 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 485918015521 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 485918015522 active site 485918015523 substrate binding site [chemical binding]; other site 485918015524 metal binding site [ion binding]; metal-binding site 485918015525 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 485918015526 active site 485918015527 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 485918015528 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 485918015529 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 485918015530 Cysteine-rich domain; Region: CCG; pfam02754 485918015531 Cysteine-rich domain; Region: CCG; pfam02754 485918015532 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 485918015533 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 485918015534 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 485918015535 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 485918015536 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 485918015537 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 485918015538 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 485918015539 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 485918015540 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 485918015541 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 485918015542 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 485918015543 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 485918015544 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 485918015545 ligand-binding site [chemical binding]; other site 485918015546 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 485918015547 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918015548 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015549 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 485918015550 catalytic residue [active] 485918015551 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 485918015552 Histidine kinase; Region: HisKA_3; pfam07730 485918015553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918015554 ATP binding site [chemical binding]; other site 485918015555 Mg2+ binding site [ion binding]; other site 485918015556 G-X-G motif; other site 485918015557 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918015558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918015559 active site 485918015560 phosphorylation site [posttranslational modification] 485918015561 intermolecular recognition site; other site 485918015562 dimerization interface [polypeptide binding]; other site 485918015563 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918015564 DNA binding residues [nucleotide binding] 485918015565 dimerization interface [polypeptide binding]; other site 485918015566 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 485918015567 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 485918015568 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 485918015569 FeS/SAM binding site; other site 485918015570 TRAM domain; Region: TRAM; pfam01938 485918015571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918015572 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 485918015573 Walker A motif; other site 485918015574 ATP binding site [chemical binding]; other site 485918015575 Walker B motif; other site 485918015576 arginine finger; other site 485918015577 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 485918015578 Lipopolysaccharide-assembly; Region: LptE; pfam04390 485918015579 Preprotein translocase SecG subunit; Region: SecG; pfam03840 485918015580 YceG-like family; Region: YceG; pfam02618 485918015581 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 485918015582 dimerization interface [polypeptide binding]; other site 485918015583 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 485918015584 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 485918015585 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 485918015586 putative active site [active] 485918015587 Zn binding site [ion binding]; other site 485918015588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 485918015589 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918015590 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918015591 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918015592 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918015593 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 485918015594 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 485918015595 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 485918015596 DinB superfamily; Region: DinB_2; pfam12867 485918015597 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 485918015598 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 485918015599 catalytic residue [active] 485918015600 TraB family; Region: TraB; pfam01963 485918015601 TraB family; Region: TraB; pfam01963 485918015602 Family of unknown function (DUF490); Region: DUF490; pfam04357 485918015603 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 485918015604 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 485918015605 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 485918015606 dimerization interface [polypeptide binding]; other site 485918015607 active site 485918015608 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918015609 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918015610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 485918015611 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 485918015612 ATP-grasp domain; Region: ATP-grasp_4; cl17255 485918015613 carboxylate-amine ligase; Provisional; Region: PRK13515 485918015614 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 485918015615 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 485918015616 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 485918015617 conserved cys residue [active] 485918015618 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 485918015619 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 485918015620 active site residue [active] 485918015621 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 485918015622 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 485918015623 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 485918015624 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 485918015625 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 485918015626 ATP-grasp domain; Region: ATP-grasp_4; cl17255 485918015627 4Fe-4S binding domain; Region: Fer4; pfam00037 485918015628 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 485918015629 NAD(P) binding site [chemical binding]; other site 485918015630 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 485918015631 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 485918015632 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 485918015633 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918015634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918015635 active site 485918015636 phosphorylation site [posttranslational modification] 485918015637 intermolecular recognition site; other site 485918015638 dimerization interface [polypeptide binding]; other site 485918015639 LytTr DNA-binding domain; Region: LytTR; smart00850 485918015640 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 485918015641 Histidine kinase; Region: His_kinase; pfam06580 485918015642 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 485918015643 ATP binding site [chemical binding]; other site 485918015644 Mg2+ binding site [ion binding]; other site 485918015645 G-X-G motif; other site 485918015646 prolyl-tRNA synthetase; Provisional; Region: PRK08661 485918015647 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 485918015648 dimer interface [polypeptide binding]; other site 485918015649 motif 1; other site 485918015650 active site 485918015651 motif 2; other site 485918015652 motif 3; other site 485918015653 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 485918015654 anticodon binding site; other site 485918015655 zinc-binding site [ion binding]; other site 485918015656 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 485918015657 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 485918015658 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 485918015659 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 485918015660 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 485918015661 active site 485918015662 NTP binding site [chemical binding]; other site 485918015663 metal binding triad [ion binding]; metal-binding site 485918015664 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 485918015665 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 485918015666 Zn2+ binding site [ion binding]; other site 485918015667 Mg2+ binding site [ion binding]; other site 485918015668 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 485918015669 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 485918015670 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 485918015671 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 485918015672 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 485918015673 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 485918015674 trimer interface [polypeptide binding]; other site 485918015675 active site 485918015676 substrate binding site [chemical binding]; other site 485918015677 CoA binding site [chemical binding]; other site 485918015678 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 485918015679 Winged helix-turn helix; Region: HTH_29; pfam13551 485918015680 Integrase core domain; Region: rve; pfam00665 485918015681 Integrase core domain; Region: rve_3; pfam13683 485918015682 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918015683 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 485918015684 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015685 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918015686 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015687 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 485918015688 classical (c) SDRs; Region: SDR_c; cd05233 485918015689 NAD(P) binding site [chemical binding]; other site 485918015690 active site 485918015691 OsmC-like protein; Region: OsmC; pfam02566 485918015692 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 485918015693 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 485918015694 putative NAD(P) binding site [chemical binding]; other site 485918015695 putative substrate binding site [chemical binding]; other site 485918015696 catalytic Zn binding site [ion binding]; other site 485918015697 structural Zn binding site [ion binding]; other site 485918015698 dimer interface [polypeptide binding]; other site 485918015699 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918015700 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918015701 catalytic residues [active] 485918015702 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918015703 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918015704 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015705 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 485918015706 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 485918015707 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 485918015708 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 485918015709 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918015710 catalytic residues [active] 485918015711 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 485918015712 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918015713 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015714 OsmC-like protein; Region: OsmC; pfam02566 485918015715 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 485918015716 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 485918015717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918015718 Major Facilitator Superfamily; Region: MFS_1; pfam07690 485918015719 putative substrate translocation pore; other site 485918015720 Transposase; Region: HTH_Tnp_1; pfam01527 485918015721 HTH-like domain; Region: HTH_21; pfam13276 485918015722 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 485918015723 Integrase core domain; Region: rve; pfam00665 485918015724 Integrase core domain; Region: rve_3; pfam13683 485918015725 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 485918015726 Beta-lactamase; Region: Beta-lactamase; pfam00144 485918015727 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918015728 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918015729 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 485918015730 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 485918015731 putative NAD(P) binding site [chemical binding]; other site 485918015732 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 485918015733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918015734 NAD(P) binding site [chemical binding]; other site 485918015735 active site 485918015736 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918015737 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015738 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 485918015739 putative hydrophobic ligand binding site [chemical binding]; other site 485918015740 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 485918015741 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918015742 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918015743 ligand binding site [chemical binding]; other site 485918015744 flexible hinge region; other site 485918015745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 485918015746 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 485918015747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 485918015748 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 485918015749 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 485918015750 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 485918015751 RNA binding surface [nucleotide binding]; other site 485918015752 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 485918015753 probable active site [active] 485918015754 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 485918015755 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918015756 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015757 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918015758 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015759 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015760 oxidoreductase; Provisional; Region: PRK06196 485918015761 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 485918015762 putative NAD(P) binding site [chemical binding]; other site 485918015763 active site 485918015764 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 485918015765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918015766 S-adenosylmethionine binding site [chemical binding]; other site 485918015767 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 485918015768 putative hydrophobic ligand binding site [chemical binding]; other site 485918015769 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 485918015770 active site 485918015771 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 485918015772 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 485918015773 Strictosidine synthase; Region: Str_synth; pfam03088 485918015774 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 485918015775 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 485918015776 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 485918015777 active site 485918015778 DoxX; Region: DoxX; cl17842 485918015779 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 485918015780 putative hydrophobic ligand binding site [chemical binding]; other site 485918015781 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 485918015782 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 485918015783 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 485918015784 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 485918015785 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 485918015786 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 485918015787 TPR repeat; Region: TPR_11; pfam13414 485918015788 preprotein translocase subunit SecA; Reviewed; Region: PRK13107 485918015789 Response regulator receiver domain; Region: Response_reg; pfam00072 485918015790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918015791 active site 485918015792 phosphorylation site [posttranslational modification] 485918015793 intermolecular recognition site; other site 485918015794 dimerization interface [polypeptide binding]; other site 485918015795 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 485918015796 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 485918015797 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 485918015798 putative substrate binding site [chemical binding]; other site 485918015799 active site 485918015800 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918015801 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918015802 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015803 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 485918015804 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 485918015805 hydroxyglutarate oxidase; Provisional; Region: PRK11728 485918015806 methionine sulfoxide reductase B; Provisional; Region: PRK00222 485918015807 SelR domain; Region: SelR; pfam01641 485918015808 methionine sulfoxide reductase A; Provisional; Region: PRK14054 485918015809 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 485918015810 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918015811 catalytic residues [active] 485918015812 Hydrogenase formation hypA family; Region: HypD; cl12072 485918015813 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 485918015814 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 485918015815 DNA-binding site [nucleotide binding]; DNA binding site 485918015816 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 485918015817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918015818 homodimer interface [polypeptide binding]; other site 485918015819 catalytic residue [active] 485918015820 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918015821 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 485918015822 Histidine kinase; Region: His_kinase; pfam06580 485918015823 two-component response regulator; Provisional; Region: PRK14084 485918015824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918015825 active site 485918015826 phosphorylation site [posttranslational modification] 485918015827 intermolecular recognition site; other site 485918015828 dimerization interface [polypeptide binding]; other site 485918015829 LytTr DNA-binding domain; Region: LytTR; smart00850 485918015830 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918015831 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015832 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918015833 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 485918015834 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 485918015835 Response regulator receiver domain; Region: Response_reg; pfam00072 485918015836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918015837 active site 485918015838 phosphorylation site [posttranslational modification] 485918015839 intermolecular recognition site; other site 485918015840 dimerization interface [polypeptide binding]; other site 485918015841 LytTr DNA-binding domain; Region: LytTR; smart00850 485918015842 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918015843 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 485918015844 binding surface 485918015845 TPR motif; other site 485918015846 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918015847 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918015848 binding surface 485918015849 TPR motif; other site 485918015850 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918015851 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 485918015852 Histidine kinase; Region: HisKA_2; pfam07568 485918015853 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 485918015854 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 485918015855 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 485918015856 TM-ABC transporter signature motif; other site 485918015857 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 485918015858 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 485918015859 TM-ABC transporter signature motif; other site 485918015860 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 485918015861 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918015862 Walker A/P-loop; other site 485918015863 ATP binding site [chemical binding]; other site 485918015864 Q-loop/lid; other site 485918015865 ABC transporter signature motif; other site 485918015866 Walker B; other site 485918015867 D-loop; other site 485918015868 H-loop/switch region; other site 485918015869 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 485918015870 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918015871 Walker A/P-loop; other site 485918015872 ATP binding site [chemical binding]; other site 485918015873 Q-loop/lid; other site 485918015874 ABC transporter signature motif; other site 485918015875 Walker B; other site 485918015876 D-loop; other site 485918015877 H-loop/switch region; other site 485918015878 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 485918015879 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 485918015880 ligand binding site [chemical binding]; other site 485918015881 Cupin domain; Region: Cupin_2; pfam07883 485918015882 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 485918015883 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 485918015884 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 485918015885 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 485918015886 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 485918015887 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 485918015888 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918015889 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918015890 FtsX-like permease family; Region: FtsX; pfam02687 485918015891 Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_3; cd11575 485918015892 putative ligand binding site [chemical binding]; other site 485918015893 putative catalytic site [active] 485918015894 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 485918015895 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 485918015896 active site 485918015897 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 485918015898 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 485918015899 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 485918015900 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 485918015901 Methyltransferase domain; Region: Methyltransf_23; pfam13489 485918015902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918015903 S-adenosylmethionine binding site [chemical binding]; other site 485918015904 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 485918015905 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 485918015906 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918015907 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 485918015908 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 485918015909 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 485918015910 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 485918015911 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918015912 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015913 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 485918015914 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 485918015915 Cu(I) binding site [ion binding]; other site 485918015916 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918015917 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015918 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918015919 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 485918015920 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918015921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918015922 active site 485918015923 phosphorylation site [posttranslational modification] 485918015924 intermolecular recognition site; other site 485918015925 dimerization interface [polypeptide binding]; other site 485918015926 LytTr DNA-binding domain; Region: LytTR; smart00850 485918015927 Histidine kinase; Region: His_kinase; pfam06580 485918015928 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 485918015929 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 485918015930 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918015931 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 485918015932 E3 interaction surface; other site 485918015933 lipoyl attachment site [posttranslational modification]; other site 485918015934 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918015935 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 485918015936 NADH(P)-binding; Region: NAD_binding_10; pfam13460 485918015937 NAD binding site [chemical binding]; other site 485918015938 substrate binding site [chemical binding]; other site 485918015939 putative active site [active] 485918015940 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918015941 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015942 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 485918015943 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 485918015944 catalytic triad [active] 485918015945 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 485918015946 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 485918015947 catalytic residue [active] 485918015948 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 485918015949 dimerization interface [polypeptide binding]; other site 485918015950 putative DNA binding site [nucleotide binding]; other site 485918015951 putative Zn2+ binding site [ion binding]; other site 485918015952 Methyltransferase domain; Region: Methyltransf_31; pfam13847 485918015953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918015954 S-adenosylmethionine binding site [chemical binding]; other site 485918015955 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 485918015956 Low molecular weight phosphatase family; Region: LMWPc; cd00115 485918015957 active site 485918015958 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 485918015959 arsenical-resistance protein; Region: acr3; TIGR00832 485918015960 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 485918015961 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 485918015962 non-specific DNA binding site [nucleotide binding]; other site 485918015963 salt bridge; other site 485918015964 sequence-specific DNA binding site [nucleotide binding]; other site 485918015965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918015966 Major Facilitator Superfamily; Region: MFS_1; pfam07690 485918015967 putative substrate translocation pore; other site 485918015968 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918015969 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918015970 Outer membrane efflux protein; Region: OEP; pfam02321 485918015971 Outer membrane efflux protein; Region: OEP; pfam02321 485918015972 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 485918015973 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 485918015974 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918015975 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 485918015976 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918015977 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 485918015978 active site 485918015979 SUMO-1 interface [polypeptide binding]; other site 485918015980 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 485918015981 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 485918015982 TPP-binding site [chemical binding]; other site 485918015983 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 485918015984 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 485918015985 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 485918015986 PYR/PP interface [polypeptide binding]; other site 485918015987 dimer interface [polypeptide binding]; other site 485918015988 TPP binding site [chemical binding]; other site 485918015989 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 485918015990 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 485918015991 TPP-binding site [chemical binding]; other site 485918015992 dimer interface [polypeptide binding]; other site 485918015993 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918015994 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918015995 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918015996 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 485918015997 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 485918015998 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918015999 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 485918016000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918016001 NAD(P) binding site [chemical binding]; other site 485918016002 active site 485918016003 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918016004 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918016005 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918016006 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918016007 ligand binding site [chemical binding]; other site 485918016008 flexible hinge region; other site 485918016009 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 485918016010 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 485918016011 substrate binding site [chemical binding]; other site 485918016012 oxyanion hole (OAH) forming residues; other site 485918016013 trimer interface [polypeptide binding]; other site 485918016014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 485918016015 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 485918016016 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 485918016017 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 485918016018 short chain dehydrogenase; Provisional; Region: PRK07454 485918016019 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 485918016020 NADP binding site [chemical binding]; other site 485918016021 substrate binding site [chemical binding]; other site 485918016022 active site 485918016023 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 485918016024 Substrate binding site [chemical binding]; other site 485918016025 Leucine rich repeat; Region: LRR_8; pfam13855 485918016026 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918016027 acyl transferase; Provisional; Region: luxD; PRK13604 485918016028 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918016029 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918016030 catalytic residues [active] 485918016031 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918016032 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918016033 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918016034 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918016035 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918016036 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918016037 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918016038 FecR protein; Region: FecR; pfam04773 485918016039 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 485918016040 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918016041 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918016042 DNA binding residues [nucleotide binding] 485918016043 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 485918016044 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 485918016045 dimer interface [polypeptide binding]; other site 485918016046 ADP-ribose binding site [chemical binding]; other site 485918016047 active site 485918016048 nudix motif; other site 485918016049 metal binding site [ion binding]; metal-binding site 485918016050 Family of unknown function (DUF695); Region: DUF695; pfam05117 485918016051 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 485918016052 active site 485918016053 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918016054 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918016055 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918016056 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918016057 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918016058 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918016059 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 485918016060 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918016061 FecR protein; Region: FecR; pfam04773 485918016062 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918016063 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918016064 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918016065 DNA binding residues [nucleotide binding] 485918016066 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 485918016067 active site 485918016068 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 485918016069 active site 485918016070 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 485918016071 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 485918016072 putative sugar binding sites [chemical binding]; other site 485918016073 Q-X-W motif; other site 485918016074 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 485918016075 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 485918016076 Uncharacterized conserved protein [Function unknown]; Region: COG3379 485918016077 DinB superfamily; Region: DinB_2; pfam12867 485918016078 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 485918016079 Two component regulator propeller; Region: Reg_prop; pfam07494 485918016080 Two component regulator propeller; Region: Reg_prop; pfam07494 485918016081 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 485918016082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918016083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918016084 dimer interface [polypeptide binding]; other site 485918016085 phosphorylation site [posttranslational modification] 485918016086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918016087 ATP binding site [chemical binding]; other site 485918016088 Mg2+ binding site [ion binding]; other site 485918016089 G-X-G motif; other site 485918016090 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 485918016091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918016092 active site 485918016093 phosphorylation site [posttranslational modification] 485918016094 intermolecular recognition site; other site 485918016095 dimerization interface [polypeptide binding]; other site 485918016096 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918016097 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918016098 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918016099 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918016100 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918016101 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918016102 SusE outer membrane protein; Region: SusE; pfam14292 485918016103 Uncharacterized subgroup of the CBM-SusE-F_like superfamily; Region: CBM_SusE-F_like_u1; cd12967 485918016104 starch binding site [chemical binding]; other site 485918016105 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956 485918016106 starch binding site [chemical binding]; other site 485918016107 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745 485918016108 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 485918016109 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 485918016110 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 485918016111 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 485918016112 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 485918016113 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 485918016114 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 485918016115 SnoaL-like domain; Region: SnoaL_2; pfam12680 485918016116 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 485918016117 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 485918016118 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918016119 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 485918016120 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 485918016121 active site 485918016122 catalytic tetrad [active] 485918016123 short chain dehydrogenase; Provisional; Region: PRK06180 485918016124 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918016125 NADP binding site [chemical binding]; other site 485918016126 active site 485918016127 steroid binding site; other site 485918016128 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918016129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918016130 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 485918016131 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 485918016132 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 485918016133 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 485918016134 putative NAD(P) binding site [chemical binding]; other site 485918016135 homodimer interface [polypeptide binding]; other site 485918016136 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918016137 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918016138 ligand binding site [chemical binding]; other site 485918016139 flexible hinge region; other site 485918016140 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 485918016141 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 485918016142 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 485918016143 putative acyl-acceptor binding pocket; other site 485918016144 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 485918016145 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 485918016146 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 485918016147 active site 485918016148 metal binding site [ion binding]; metal-binding site 485918016149 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 485918016150 mce related protein; Region: MCE; pfam02470 485918016151 Domain of unknown function DUF59; Region: DUF59; cl00941 485918016152 OstA-like protein; Region: OstA_2; pfam13100 485918016153 OstA-like protein; Region: OstA; pfam03968 485918016154 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 485918016155 putative carbohydrate kinase; Provisional; Region: PRK10565 485918016156 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 485918016157 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 485918016158 putative substrate binding site [chemical binding]; other site 485918016159 putative ATP binding site [chemical binding]; other site 485918016160 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 485918016161 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 485918016162 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918016163 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918016164 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918016165 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918016166 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918016167 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 485918016168 Penicillinase repressor; Region: Pencillinase_R; pfam03965 485918016169 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 485918016170 Peptidase C1-like family; Region: Peptidase_C1_2; cl17447 485918016171 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 485918016172 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 485918016173 triosephosphate isomerase; Provisional; Region: PRK14567 485918016174 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 485918016175 dimer interface [polypeptide binding]; other site 485918016176 substrate binding site [chemical binding]; other site 485918016177 catalytic triad [active] 485918016178 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 485918016179 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 485918016180 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 485918016181 putative trimer interface [polypeptide binding]; other site 485918016182 putative CoA binding site [chemical binding]; other site 485918016183 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 485918016184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 485918016185 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 485918016186 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 485918016187 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 485918016188 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918016189 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918016190 DNA binding residues [nucleotide binding] 485918016191 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918016192 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 485918016193 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918016194 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 485918016195 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 485918016196 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 485918016197 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 485918016198 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 485918016199 putative dimer interface [polypeptide binding]; other site 485918016200 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 485918016201 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 485918016202 dimer interface [polypeptide binding]; other site 485918016203 active site 485918016204 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 485918016205 catalytic residues [active] 485918016206 substrate binding site [chemical binding]; other site 485918016207 WbqC-like protein family; Region: WbqC; pfam08889 485918016208 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 485918016209 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 485918016210 metal-binding site [ion binding] 485918016211 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 485918016212 active site 485918016213 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 485918016214 active site 485918016215 Ap6A binding site [chemical binding]; other site 485918016216 nudix motif; other site 485918016217 metal binding site [ion binding]; metal-binding site 485918016218 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 485918016219 CoenzymeA binding site [chemical binding]; other site 485918016220 subunit interaction site [polypeptide binding]; other site 485918016221 PHB binding site; other site 485918016222 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 485918016223 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 485918016224 active site 485918016225 (T/H)XGH motif; other site 485918016226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918016227 S-adenosylmethionine binding site [chemical binding]; other site 485918016228 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 485918016229 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 485918016230 putative efflux protein, MATE family; Region: matE; TIGR00797 485918016231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 485918016232 TPR motif; other site 485918016233 binding surface 485918016234 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 485918016235 TPR motif; other site 485918016236 binding surface 485918016237 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918016238 TPR motif; other site 485918016239 binding surface 485918016240 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 485918016241 active site 485918016242 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 485918016243 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 485918016244 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 485918016245 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 485918016246 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 485918016247 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918016248 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 485918016249 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918016250 DNA binding residues [nucleotide binding] 485918016251 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 485918016252 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 485918016253 tetramer interface [polypeptide binding]; other site 485918016254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918016255 catalytic residue [active] 485918016256 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 485918016257 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 485918016258 active site 485918016259 HIGH motif; other site 485918016260 nucleotide binding site [chemical binding]; other site 485918016261 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 485918016262 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 485918016263 active site 485918016264 KMSKS motif; other site 485918016265 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 485918016266 tRNA binding surface [nucleotide binding]; other site 485918016267 anticodon binding site; other site 485918016268 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 485918016269 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 485918016270 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 485918016271 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 485918016272 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 485918016273 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 485918016274 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 485918016275 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 485918016276 ring oligomerisation interface [polypeptide binding]; other site 485918016277 ATP/Mg binding site [chemical binding]; other site 485918016278 stacking interactions; other site 485918016279 hinge regions; other site 485918016280 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 485918016281 oligomerisation interface [polypeptide binding]; other site 485918016282 mobile loop; other site 485918016283 roof hairpin; other site 485918016284 transcription antitermination factor NusB; Region: nusB; TIGR01951 485918016285 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 485918016286 Preprotein translocase subunit; Region: YajC; pfam02699 485918016287 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 485918016288 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 485918016289 CoA-binding site [chemical binding]; other site 485918016290 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 485918016291 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 485918016292 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 485918016293 ATP binding site [chemical binding]; other site 485918016294 putative Mg++ binding site [ion binding]; other site 485918016295 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 485918016296 nucleotide binding region [chemical binding]; other site 485918016297 ATP-binding site [chemical binding]; other site 485918016298 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 485918016299 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 485918016300 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 485918016301 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 485918016302 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 485918016303 Protein export membrane protein; Region: SecD_SecF; pfam02355 485918016304 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 485918016305 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 485918016306 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 485918016307 aspartate aminotransferase; Provisional; Region: PRK05764 485918016308 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 485918016309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918016310 homodimer interface [polypeptide binding]; other site 485918016311 catalytic residue [active] 485918016312 Peptidase family M23; Region: Peptidase_M23; pfam01551 485918016313 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 485918016314 Methyltransferase domain; Region: Methyltransf_23; pfam13489 485918016315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918016316 S-adenosylmethionine binding site [chemical binding]; other site 485918016317 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 485918016318 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 485918016319 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 485918016320 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 485918016321 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 485918016322 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 485918016323 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 485918016324 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 485918016325 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 485918016326 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 485918016327 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 485918016328 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918016329 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 485918016330 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 485918016331 Shikimate kinase; Region: SKI; pfam01202 485918016332 ADP binding site [chemical binding]; other site 485918016333 magnesium binding site [ion binding]; other site 485918016334 putative shikimate binding site; other site 485918016335 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 485918016336 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 485918016337 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 485918016338 trimer interface [polypeptide binding]; other site 485918016339 active site 485918016340 Cytochrome c; Region: Cytochrom_C; cl11414 485918016341 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 485918016342 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918016343 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918016344 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 485918016345 N-terminal plug; other site 485918016346 ligand-binding site [chemical binding]; other site 485918016347 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918016348 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918016349 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 485918016350 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 485918016351 putative NAD(P) binding site [chemical binding]; other site 485918016352 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 485918016353 AAA domain; Region: AAA_33; pfam13671 485918016354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 485918016355 Putative glucoamylase; Region: Glycoamylase; pfam10091 485918016356 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 485918016357 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 485918016358 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 485918016359 Predicted integral membrane protein [Function unknown]; Region: COG5637 485918016360 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 485918016361 putative hydrophobic ligand binding site [chemical binding]; other site 485918016362 YtxH-like protein; Region: YtxH; cl02079 485918016363 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918016364 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918016365 catalytic residues [active] 485918016366 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918016367 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 485918016368 active site 485918016369 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918016370 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 485918016371 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 485918016372 Uncharacterized conserved protein [Function unknown]; Region: COG2128 485918016373 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 485918016374 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918016375 DNA binding residues [nucleotide binding] 485918016376 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 485918016377 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 485918016378 catalytic residue [active] 485918016379 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 485918016380 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 485918016381 FAD binding site [chemical binding]; other site 485918016382 homotetramer interface [polypeptide binding]; other site 485918016383 substrate binding pocket [chemical binding]; other site 485918016384 catalytic base [active] 485918016385 Arginase family; Region: Arginase; cd09989 485918016386 active site 485918016387 Mn binding site [ion binding]; other site 485918016388 oligomer interface [polypeptide binding]; other site 485918016389 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 485918016390 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 485918016391 Phosphotransferase enzyme family; Region: APH; pfam01636 485918016392 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 485918016393 active site 485918016394 ATP binding site [chemical binding]; other site 485918016395 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 485918016396 substrate binding site [chemical binding]; other site 485918016397 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 485918016398 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918016399 dimer interface [polypeptide binding]; other site 485918016400 phosphorylation site [posttranslational modification] 485918016401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918016402 ATP binding site [chemical binding]; other site 485918016403 Mg2+ binding site [ion binding]; other site 485918016404 G-X-G motif; other site 485918016405 Response regulator receiver domain; Region: Response_reg; pfam00072 485918016406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918016407 active site 485918016408 phosphorylation site [posttranslational modification] 485918016409 intermolecular recognition site; other site 485918016410 dimerization interface [polypeptide binding]; other site 485918016411 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 485918016412 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 485918016413 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 485918016414 putative phosphate acyltransferase; Provisional; Region: PRK05331 485918016415 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 485918016416 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 485918016417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918016418 dimer interface [polypeptide binding]; other site 485918016419 phosphorylation site [posttranslational modification] 485918016420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918016421 ATP binding site [chemical binding]; other site 485918016422 Mg2+ binding site [ion binding]; other site 485918016423 G-X-G motif; other site 485918016424 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 485918016425 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 485918016426 homodimer interface [polypeptide binding]; other site 485918016427 metal binding site [ion binding]; metal-binding site 485918016428 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 485918016429 homodimer interface [polypeptide binding]; other site 485918016430 active site 485918016431 putative chemical substrate binding site [chemical binding]; other site 485918016432 metal binding site [ion binding]; metal-binding site 485918016433 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 485918016434 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 485918016435 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 485918016436 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 485918016437 RNA binding site [nucleotide binding]; other site 485918016438 enoyl-CoA hydratase; Provisional; Region: PRK05862 485918016439 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 485918016440 substrate binding site [chemical binding]; other site 485918016441 oxyanion hole (OAH) forming residues; other site 485918016442 trimer interface [polypeptide binding]; other site 485918016443 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 485918016444 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 485918016445 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_2; cd08974 485918016446 putative DNA binding site [nucleotide binding]; other site 485918016447 catalytic residue [active] 485918016448 putative H2TH interface [polypeptide binding]; other site 485918016449 putative catalytic residues [active] 485918016450 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 485918016451 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 485918016452 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 485918016453 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 485918016454 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 485918016455 AAA domain; Region: AAA_21; pfam13304 485918016456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918016457 Tetratricopeptide repeat; Region: TPR_16; pfam13432 485918016458 TPR motif; other site 485918016459 binding surface 485918016460 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 485918016461 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918016462 NmrA-like family; Region: NmrA; pfam05368 485918016463 NAD(P) binding site [chemical binding]; other site 485918016464 active site 485918016465 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 485918016466 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 485918016467 putative dimer interface [polypeptide binding]; other site 485918016468 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 485918016469 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 485918016470 catalytic residues [active] 485918016471 catalytic nucleophile [active] 485918016472 Recombinase; Region: Recombinase; pfam07508 485918016473 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 485918016474 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 485918016475 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 485918016476 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 485918016477 Walker A motif; other site 485918016478 ATP binding site [chemical binding]; other site 485918016479 Walker B motif; other site 485918016480 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 485918016481 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 485918016482 active site 485918016483 DNA binding site [nucleotide binding] 485918016484 Int/Topo IB signature motif; other site 485918016485 TrwC relaxase; Region: TrwC; pfam08751 485918016486 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 485918016487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918016488 Walker A motif; other site 485918016489 ATP binding site [chemical binding]; other site 485918016490 Walker B motif; other site 485918016491 Family description; Region: UvrD_C_2; pfam13538 485918016492 RES domain; Region: RES; pfam08808 485918016493 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 485918016494 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 485918016495 Protein of unknown function (DUF2031); Region: DUF2031; cl09810 485918016496 Resolvase, N terminal domain; Region: Resolvase; smart00857 485918016497 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 485918016498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918016499 AAA domain; Region: AAA_21; pfam13304 485918016500 Walker A/P-loop; other site 485918016501 ATP binding site [chemical binding]; other site 485918016502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918016503 ABC transporter signature motif; other site 485918016504 Walker B; other site 485918016505 D-loop; other site 485918016506 H-loop/switch region; other site 485918016507 Transposase; Region: HTH_Tnp_1; pfam01527 485918016508 HTH-like domain; Region: HTH_21; pfam13276 485918016509 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 485918016510 Integrase core domain; Region: rve; pfam00665 485918016511 Integrase core domain; Region: rve_3; pfam13683 485918016512 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 485918016513 active site 485918016514 catalytic triad [active] 485918016515 oxyanion hole [active] 485918016516 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 485918016517 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 485918016518 Domain of unknown function DUF20; Region: UPF0118; pfam01594 485918016519 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 485918016520 Active site serine [active] 485918016521 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 485918016522 Short C-terminal domain; Region: SHOCT; pfam09851 485918016523 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 485918016524 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918016525 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918016526 SusD family; Region: SusD; pfam07980 485918016527 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918016528 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918016529 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918016530 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918016531 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 485918016532 Two component regulator propeller; Region: Reg_prop; pfam07494 485918016533 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 485918016534 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918016535 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918016536 dimer interface [polypeptide binding]; other site 485918016537 phosphorylation site [posttranslational modification] 485918016538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918016539 ATP binding site [chemical binding]; other site 485918016540 Mg2+ binding site [ion binding]; other site 485918016541 G-X-G motif; other site 485918016542 Response regulator receiver domain; Region: Response_reg; pfam00072 485918016543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918016544 active site 485918016545 phosphorylation site [posttranslational modification] 485918016546 intermolecular recognition site; other site 485918016547 dimerization interface [polypeptide binding]; other site 485918016548 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918016549 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918016550 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 485918016551 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918016552 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918016553 DNA binding residues [nucleotide binding] 485918016554 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918016555 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918016556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918016557 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 485918016558 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 485918016559 FMN binding site [chemical binding]; other site 485918016560 substrate binding site [chemical binding]; other site 485918016561 putative catalytic residue [active] 485918016562 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 485918016563 short chain dehydrogenase; Provisional; Region: PRK06180 485918016564 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918016565 NADP binding site [chemical binding]; other site 485918016566 active site 485918016567 steroid binding site; other site 485918016568 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918016569 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918016570 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 485918016571 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 485918016572 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 485918016573 putative NAD(P) binding site [chemical binding]; other site 485918016574 Beta-lactamase; Region: Beta-lactamase; pfam00144 485918016575 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 485918016576 propionate/acetate kinase; Provisional; Region: PRK12379 485918016577 Acetokinase family; Region: Acetate_kinase; cl17229 485918016578 putative phosphoketolase; Provisional; Region: PRK05261 485918016579 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 485918016580 TPP-binding site; other site 485918016581 XFP C-terminal domain; Region: XFP_C; pfam09363 485918016582 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 485918016583 MarR family; Region: MarR_2; pfam12802 485918016584 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 485918016585 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 485918016586 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918016587 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 485918016588 YceI-like domain; Region: YceI; pfam04264 485918016589 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 485918016590 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 485918016591 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 485918016592 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918016593 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918016594 DNA binding residues [nucleotide binding] 485918016595 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 485918016596 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 485918016597 FecR protein; Region: FecR; pfam04773 485918016598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918016599 short chain dehydrogenase; Provisional; Region: PRK06181 485918016600 NAD(P) binding site [chemical binding]; other site 485918016601 active site 485918016602 CheB methylesterase; Region: CheB_methylest; pfam01339 485918016603 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 485918016604 active site 485918016605 DNA binding site [nucleotide binding] 485918016606 DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776 485918016607 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 485918016608 DNA binding site [nucleotide binding] 485918016609 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 485918016610 nucleotide binding site [chemical binding]; other site 485918016611 Response regulator receiver domain; Region: Response_reg; pfam00072 485918016612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918016613 active site 485918016614 phosphorylation site [posttranslational modification] 485918016615 intermolecular recognition site; other site 485918016616 dimerization interface [polypeptide binding]; other site 485918016617 LytTr DNA-binding domain; Region: LytTR; smart00850 485918016618 Histidine kinase; Region: His_kinase; pfam06580 485918016619 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918016620 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918016621 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 485918016622 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 485918016623 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 485918016624 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918016625 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918016626 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 485918016627 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 485918016628 active site 485918016629 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 485918016630 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 485918016631 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 485918016632 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 485918016633 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 485918016634 RHS Repeat; Region: RHS_repeat; pfam05593 485918016635 RHS Repeat; Region: RHS_repeat; pfam05593 485918016636 RHS Repeat; Region: RHS_repeat; pfam05593 485918016637 RHS protein; Region: RHS; pfam03527 485918016638 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 485918016639 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 485918016640 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 485918016641 Methane oxygenase PmoA; Region: PmoA; pfam14100 485918016642 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 485918016643 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 485918016644 active site 485918016645 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918016646 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 485918016647 FecR protein; Region: FecR; pfam04773 485918016648 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918016649 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918016650 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918016651 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918016652 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918016653 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 485918016654 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918016655 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918016656 catalytic residues [active] 485918016657 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 485918016658 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918016659 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918016660 catalytic residues [active] 485918016661 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 485918016662 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 485918016663 nucleotide binding site [chemical binding]; other site 485918016664 NEF interaction site [polypeptide binding]; other site 485918016665 SBD interface [polypeptide binding]; other site 485918016666 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 485918016667 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 485918016668 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 485918016669 ligand binding site [chemical binding]; other site 485918016670 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 485918016671 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 485918016672 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 485918016673 active site 485918016674 HIGH motif; other site 485918016675 nucleotide binding site [chemical binding]; other site 485918016676 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 485918016677 KMSK motif region; other site 485918016678 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 485918016679 tRNA binding surface [nucleotide binding]; other site 485918016680 anticodon binding site; other site 485918016681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918016682 binding surface 485918016683 Tetratricopeptide repeat; Region: TPR_16; pfam13432 485918016684 TPR motif; other site 485918016685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918016686 binding surface 485918016687 TPR motif; other site 485918016688 TPR repeat; Region: TPR_11; pfam13414 485918016689 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918016690 binding surface 485918016691 TPR motif; other site 485918016692 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 485918016693 active site 485918016694 catalytic motif [active] 485918016695 Zn binding site [ion binding]; other site 485918016696 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 485918016697 Catalytic site [active] 485918016698 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 485918016699 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 485918016700 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918016701 Response regulator receiver domain; Region: Response_reg; pfam00072 485918016702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918016703 active site 485918016704 phosphorylation site [posttranslational modification] 485918016705 intermolecular recognition site; other site 485918016706 dimerization interface [polypeptide binding]; other site 485918016707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918016708 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 485918016709 Walker A motif; other site 485918016710 ATP binding site [chemical binding]; other site 485918016711 Walker B motif; other site 485918016712 arginine finger; other site 485918016713 serine O-acetyltransferase; Region: cysE; TIGR01172 485918016714 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 485918016715 trimer interface [polypeptide binding]; other site 485918016716 active site 485918016717 substrate binding site [chemical binding]; other site 485918016718 CoA binding site [chemical binding]; other site 485918016719 cysteine synthase B; Region: cysM; TIGR01138 485918016720 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 485918016721 dimer interface [polypeptide binding]; other site 485918016722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918016723 catalytic residue [active] 485918016724 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 485918016725 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 485918016726 alpha subunit interface [polypeptide binding]; other site 485918016727 TPP binding site [chemical binding]; other site 485918016728 heterodimer interface [polypeptide binding]; other site 485918016729 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 485918016730 acetyl-CoA C-acetyltransferase; Region: PLN02644 485918016731 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 485918016732 dimer interface [polypeptide binding]; other site 485918016733 active site 485918016734 Uncharacterized conserved protein [Function unknown]; Region: COG5276 485918016735 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918016736 SusD family; Region: SusD; pfam07980 485918016737 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918016738 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918016739 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918016740 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918016741 FecR protein; Region: FecR; pfam04773 485918016742 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918016743 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918016744 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918016745 DNA binding residues [nucleotide binding] 485918016746 DNA primase, catalytic core; Region: dnaG; TIGR01391 485918016747 CHC2 zinc finger; Region: zf-CHC2; pfam01807 485918016748 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 485918016749 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 485918016750 active site 485918016751 metal binding site [ion binding]; metal-binding site 485918016752 interdomain interaction site; other site 485918016753 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 485918016754 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 485918016755 folate binding site [chemical binding]; other site 485918016756 NADP+ binding site [chemical binding]; other site 485918016757 thymidylate synthase; Reviewed; Region: thyA; PRK01827 485918016758 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 485918016759 dimerization interface [polypeptide binding]; other site 485918016760 active site 485918016761 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 485918016762 proline dehydrogenase; Region: PLN02681 485918016763 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918016764 FecR protein; Region: FecR; pfam04773 485918016765 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 485918016766 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 485918016767 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 485918016768 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 485918016769 Sodium Bile acid symporter family; Region: SBF; pfam01758 485918016770 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 485918016771 dihydroorotase; Provisional; Region: PRK09237 485918016772 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 485918016773 active site 485918016774 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 485918016775 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 485918016776 catalytic residue [active] 485918016777 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 485918016778 homotrimer interaction site [polypeptide binding]; other site 485918016779 putative active site [active] 485918016780 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 485918016781 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918016782 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918016783 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918016784 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918016785 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918016786 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918016787 FecR protein; Region: FecR; pfam04773 485918016788 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 485918016789 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918016790 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918016791 DNA binding residues [nucleotide binding] 485918016792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 485918016793 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 485918016794 Active_site [active] 485918016795 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 485918016796 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 485918016797 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 485918016798 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 485918016799 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 485918016800 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 485918016801 ligand binding site [chemical binding]; other site 485918016802 Predicted amidohydrolase [General function prediction only]; Region: COG0388 485918016803 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 485918016804 active site 485918016805 catalytic triad [active] 485918016806 dimer interface [polypeptide binding]; other site 485918016807 PAS fold; Region: PAS_4; pfam08448 485918016808 GAF domain; Region: GAF; pfam01590 485918016809 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 485918016810 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918016811 dimer interface [polypeptide binding]; other site 485918016812 phosphorylation site [posttranslational modification] 485918016813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918016814 ATP binding site [chemical binding]; other site 485918016815 Mg2+ binding site [ion binding]; other site 485918016816 G-X-G motif; other site 485918016817 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 485918016818 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 485918016819 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 485918016820 peptidase T; Region: peptidase-T; TIGR01882 485918016821 metal binding site [ion binding]; metal-binding site 485918016822 dimer interface [polypeptide binding]; other site 485918016823 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 485918016824 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 485918016825 THF binding site; other site 485918016826 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 485918016827 substrate binding site [chemical binding]; other site 485918016828 THF binding site; other site 485918016829 zinc-binding site [ion binding]; other site 485918016830 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 485918016831 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 485918016832 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 485918016833 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 485918016834 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 485918016835 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 485918016836 putative active site [active] 485918016837 substrate binding site [chemical binding]; other site 485918016838 putative cosubstrate binding site; other site 485918016839 catalytic site [active] 485918016840 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 485918016841 substrate binding site [chemical binding]; other site 485918016842 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 485918016843 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 485918016844 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 485918016845 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 485918016846 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 485918016847 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 485918016848 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 485918016849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918016850 S-adenosylmethionine binding site [chemical binding]; other site 485918016851 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 485918016852 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 485918016853 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 485918016854 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 485918016855 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 485918016856 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 485918016857 ligand binding site [chemical binding]; other site 485918016858 homodimer interface [polypeptide binding]; other site 485918016859 NAD(P) binding site [chemical binding]; other site 485918016860 trimer interface B [polypeptide binding]; other site 485918016861 trimer interface A [polypeptide binding]; other site 485918016862 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 485918016863 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 485918016864 putative DNA binding site [nucleotide binding]; other site 485918016865 catalytic residue [active] 485918016866 putative H2TH interface [polypeptide binding]; other site 485918016867 putative catalytic residues [active] 485918016868 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 485918016869 Protein of unknown function DUF72; Region: DUF72; pfam01904 485918016870 protoporphyrinogen oxidase; Region: PLN02576 485918016871 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 485918016872 Protein of unknown function, DUF484; Region: DUF484; cl17449 485918016873 ferrochelatase; Reviewed; Region: hemH; PRK00035 485918016874 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 485918016875 C-terminal domain interface [polypeptide binding]; other site 485918016876 active site 485918016877 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 485918016878 active site 485918016879 N-terminal domain interface [polypeptide binding]; other site 485918016880 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 485918016881 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 485918016882 tRNA; other site 485918016883 putative tRNA binding site [nucleotide binding]; other site 485918016884 putative NADP binding site [chemical binding]; other site 485918016885 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 485918016886 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 485918016887 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 485918016888 domain interfaces; other site 485918016889 active site 485918016890 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 485918016891 active site 485918016892 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 485918016893 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 485918016894 substrate binding site [chemical binding]; other site 485918016895 active site 485918016896 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 485918016897 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 485918016898 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 485918016899 dimer interface [polypeptide binding]; other site 485918016900 allosteric magnesium binding site [ion binding]; other site 485918016901 active site 485918016902 aspartate-rich active site metal binding site; other site 485918016903 Schiff base residues; other site 485918016904 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 485918016905 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 485918016906 inhibitor-cofactor binding pocket; inhibition site 485918016907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918016908 catalytic residue [active] 485918016909 Predicted esterase [General function prediction only]; Region: COG0400 485918016910 Methyltransferase domain; Region: Methyltransf_24; pfam13578 485918016911 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 485918016912 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 485918016913 Ligand binding site; other site 485918016914 Putative Catalytic site; other site 485918016915 DXD motif; other site 485918016916 Transcriptional regulator [Transcription]; Region: LysR; COG0583 485918016917 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 485918016918 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 485918016919 dimerization interface [polypeptide binding]; other site 485918016920 Peptidase family M48; Region: Peptidase_M48; pfam01435 485918016921 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 485918016922 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 485918016923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918016924 S-adenosylmethionine binding site [chemical binding]; other site 485918016925 NIPSNAP; Region: NIPSNAP; pfam07978 485918016926 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 485918016927 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 485918016928 RNase E interface [polypeptide binding]; other site 485918016929 trimer interface [polypeptide binding]; other site 485918016930 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 485918016931 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 485918016932 RNase E interface [polypeptide binding]; other site 485918016933 trimer interface [polypeptide binding]; other site 485918016934 active site 485918016935 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 485918016936 putative nucleic acid binding region [nucleotide binding]; other site 485918016937 G-X-X-G motif; other site 485918016938 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 485918016939 RNA binding site [nucleotide binding]; other site 485918016940 domain interface; other site 485918016941 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 485918016942 16S/18S rRNA binding site [nucleotide binding]; other site 485918016943 S13e-L30e interaction site [polypeptide binding]; other site 485918016944 25S rRNA binding site [nucleotide binding]; other site 485918016945 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 485918016946 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 485918016947 Walker A/P-loop; other site 485918016948 ATP binding site [chemical binding]; other site 485918016949 Q-loop/lid; other site 485918016950 ABC transporter signature motif; other site 485918016951 Walker B; other site 485918016952 D-loop; other site 485918016953 H-loop/switch region; other site 485918016954 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 485918016955 Penicillinase repressor; Region: Pencillinase_R; pfam03965 485918016956 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 485918016957 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 485918016958 Phosphoribosylaminoimidazole (AIR) synthetase [Nucleotide transport and metabolism]; Region: PurM; COG0150 485918016959 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 485918016960 dimerization interface [polypeptide binding]; other site 485918016961 ATP binding site [chemical binding]; other site 485918016962 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 485918016963 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 485918016964 active site 485918016965 Riboflavin kinase; Region: Flavokinase; pfam01687 485918016966 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 485918016967 DNA polymerase III, delta subunit; Region: holA; TIGR01128 485918016968 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 485918016969 active site 485918016970 catalytic site [active] 485918016971 substrate binding site [chemical binding]; other site 485918016972 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 485918016973 Response regulator receiver domain; Region: Response_reg; pfam00072 485918016974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918016975 active site 485918016976 phosphorylation site [posttranslational modification] 485918016977 intermolecular recognition site; other site 485918016978 dimerization interface [polypeptide binding]; other site 485918016979 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 485918016980 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918016981 Walker A/P-loop; other site 485918016982 ATP binding site [chemical binding]; other site 485918016983 Q-loop/lid; other site 485918016984 ABC transporter signature motif; other site 485918016985 Walker B; other site 485918016986 D-loop; other site 485918016987 H-loop/switch region; other site 485918016988 ABC transporter; Region: ABC_tran_2; pfam12848 485918016989 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 485918016990 EcsC protein family; Region: EcsC; pfam12787 485918016991 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 485918016992 active site clefts [active] 485918016993 zinc binding site [ion binding]; other site 485918016994 dimer interface [polypeptide binding]; other site 485918016995 glutamate racemase; Provisional; Region: PRK00865 485918016996 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 485918016997 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918016998 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 485918016999 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 485918017000 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 485918017001 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 485918017002 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 485918017003 L-aspartate oxidase; Provisional; Region: PRK06175 485918017004 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 485918017005 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 485918017006 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 485918017007 putative Iron-sulfur protein interface [polypeptide binding]; other site 485918017008 proximal heme binding site [chemical binding]; other site 485918017009 distal heme binding site [chemical binding]; other site 485918017010 putative dimer interface [polypeptide binding]; other site 485918017011 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 485918017012 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: PRK12570 485918017013 putative active site [active] 485918017014 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 485918017015 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 485918017016 C-terminal peptidase (prc); Region: prc; TIGR00225 485918017017 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 485918017018 protein binding site [polypeptide binding]; other site 485918017019 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 485918017020 Catalytic dyad [active] 485918017021 GTP-binding protein Der; Reviewed; Region: PRK00093 485918017022 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 485918017023 G1 box; other site 485918017024 GTP/Mg2+ binding site [chemical binding]; other site 485918017025 Switch I region; other site 485918017026 G2 box; other site 485918017027 Switch II region; other site 485918017028 G3 box; other site 485918017029 G4 box; other site 485918017030 G5 box; other site 485918017031 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 485918017032 G1 box; other site 485918017033 GTP/Mg2+ binding site [chemical binding]; other site 485918017034 Switch I region; other site 485918017035 G2 box; other site 485918017036 G3 box; other site 485918017037 Switch II region; other site 485918017038 G4 box; other site 485918017039 G5 box; other site 485918017040 GTPase Era; Reviewed; Region: era; PRK00089 485918017041 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 485918017042 G1 box; other site 485918017043 GTP/Mg2+ binding site [chemical binding]; other site 485918017044 Switch I region; other site 485918017045 G2 box; other site 485918017046 Switch II region; other site 485918017047 G3 box; other site 485918017048 G4 box; other site 485918017049 G5 box; other site 485918017050 KH domain; Region: KH_2; pfam07650 485918017051 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 485918017052 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 485918017053 dimer interface [polypeptide binding]; other site 485918017054 ssDNA binding site [nucleotide binding]; other site 485918017055 tetramer (dimer of dimers) interface [polypeptide binding]; other site 485918017056 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918017057 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918017058 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918017059 argininosuccinate lyase; Provisional; Region: PRK00855 485918017060 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 485918017061 active sites [active] 485918017062 tetramer interface [polypeptide binding]; other site 485918017063 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 485918017064 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 485918017065 metal binding site [ion binding]; metal-binding site 485918017066 dimer interface [polypeptide binding]; other site 485918017067 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 485918017068 nucleotide binding site [chemical binding]; other site 485918017069 N-acetyl-L-glutamate binding site [chemical binding]; other site 485918017070 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 485918017071 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 485918017072 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 485918017073 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 485918017074 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 485918017075 inhibitor-cofactor binding pocket; inhibition site 485918017076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918017077 catalytic residue [active] 485918017078 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 485918017079 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 485918017080 argininosuccinate synthase; Provisional; Region: PRK13820 485918017081 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 485918017082 Ligand Binding Site [chemical binding]; other site 485918017083 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918017084 Coenzyme A binding pocket [chemical binding]; other site 485918017085 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 485918017086 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 485918017087 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 485918017088 Fn3 associated; Region: Fn3_assoc; pfam13287 485918017089 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 485918017090 sugar binding site [chemical binding]; other site 485918017091 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 485918017092 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 485918017093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918017094 Major Facilitator Superfamily; Region: MFS_1; pfam07690 485918017095 putative substrate translocation pore; other site 485918017096 glucose/galactose transporter; Region: gluP; TIGR01272 485918017097 L-fucose transporter; Provisional; Region: PRK10133; cl17665 485918017098 glucose/galactose transporter; Region: gluP; TIGR01272 485918017099 L-fucose transporter; Provisional; Region: PRK10133; cl17665 485918017100 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 485918017101 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 485918017102 nucleotide binding site [chemical binding]; other site 485918017103 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 485918017104 active site 485918017105 dimer interface [polypeptide binding]; other site 485918017106 catalytic nucleophile [active] 485918017107 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 485918017108 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918017109 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918017110 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918017111 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918017112 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918017113 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918017114 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918017115 FecR protein; Region: FecR; pfam04773 485918017116 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918017117 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918017118 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918017119 DNA binding residues [nucleotide binding] 485918017120 glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122 485918017121 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 485918017122 active site 485918017123 trimer interface [polypeptide binding]; other site 485918017124 allosteric site; other site 485918017125 active site lid [active] 485918017126 hexamer (dimer of trimers) interface [polypeptide binding]; other site 485918017127 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 485918017128 HD domain; Region: HD_4; pfam13328 485918017129 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 485918017130 Leucine carboxyl methyltransferase; Region: LCM; cl01306 485918017131 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 485918017132 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 485918017133 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 485918017134 FAD binding domain; Region: FAD_binding_4; pfam01565 485918017135 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 485918017136 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 485918017137 primosomal protein N' Region: priA; TIGR00595 485918017138 ATP binding site [chemical binding]; other site 485918017139 putative Mg++ binding site [ion binding]; other site 485918017140 helicase superfamily c-terminal domain; Region: HELICc; smart00490 485918017141 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 485918017142 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 485918017143 putative acyl-acceptor binding pocket; other site 485918017144 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 485918017145 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 485918017146 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 485918017147 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 485918017148 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 485918017149 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 485918017150 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 485918017151 Ligand Binding Site [chemical binding]; other site 485918017152 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 485918017153 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 485918017154 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 485918017155 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 485918017156 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 485918017157 FeoA domain; Region: FeoA; pfam04023 485918017158 manganese transport protein MntH; Reviewed; Region: PRK00701 485918017159 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 485918017160 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 485918017161 Ligand Binding Site [chemical binding]; other site 485918017162 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 485918017163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918017164 active site 485918017165 phosphorylation site [posttranslational modification] 485918017166 intermolecular recognition site; other site 485918017167 dimerization interface [polypeptide binding]; other site 485918017168 LytTr DNA-binding domain; Region: LytTR; smart00850 485918017169 Histidine kinase; Region: His_kinase; pfam06580 485918017170 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 485918017171 ATP binding site [chemical binding]; other site 485918017172 Mg2+ binding site [ion binding]; other site 485918017173 G-X-G motif; other site 485918017174 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 485918017175 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 485918017176 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 485918017177 active site 485918017178 catalytic triad [active] 485918017179 oxyanion hole [active] 485918017180 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 485918017181 isocitrate dehydrogenase; Validated; Region: PRK07362 485918017182 isocitrate dehydrogenase; Validated; Region: PRK08299 485918017183 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 485918017184 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 485918017185 active site 485918017186 catalytic tetrad [active] 485918017187 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918017188 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918017189 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918017190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 485918017191 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 485918017192 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 485918017193 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 485918017194 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 485918017195 metal-binding site [ion binding] 485918017196 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 485918017197 purine nucleoside phosphorylase; Provisional; Region: PRK08202 485918017198 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 485918017199 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 485918017200 CoA-ligase; Region: Ligase_CoA; pfam00549 485918017201 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 485918017202 SprT homologues; Region: SprT; cl01182 485918017203 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 485918017204 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 485918017205 Transglycosylase; Region: Transgly; pfam00912 485918017206 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 485918017207 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 485918017208 Peptidase family M28; Region: Peptidase_M28; pfam04389 485918017209 metal binding site [ion binding]; metal-binding site 485918017210 membrane protein insertase; Provisional; Region: PRK01318 485918017211 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 485918017212 CTP synthetase; Validated; Region: pyrG; PRK05380 485918017213 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 485918017214 Catalytic site [active] 485918017215 active site 485918017216 UTP binding site [chemical binding]; other site 485918017217 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 485918017218 active site 485918017219 putative oxyanion hole; other site 485918017220 catalytic triad [active] 485918017221 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 485918017222 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 485918017223 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 485918017224 Zn2+ binding site [ion binding]; other site 485918017225 Mg2+ binding site [ion binding]; other site 485918017226 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 485918017227 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 485918017228 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 485918017229 active site 485918017230 SAM binding site [chemical binding]; other site 485918017231 homodimer interface [polypeptide binding]; other site 485918017232 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 485918017233 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 485918017234 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 485918017235 HEPN domain; Region: HEPN; cl00824 485918017236 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 485918017237 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 485918017238 motif II; other site 485918017239 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 485918017240 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 485918017241 RNA binding site [nucleotide binding]; other site 485918017242 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 485918017243 RNA binding site [nucleotide binding]; other site 485918017244 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 485918017245 RNA binding site [nucleotide binding]; other site 485918017246 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 485918017247 RNA binding site [nucleotide binding]; other site 485918017248 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 485918017249 RNA binding site [nucleotide binding]; other site 485918017250 Rhomboid family; Region: Rhomboid; pfam01694 485918017251 Der GTPase activator (YihI); Region: YihI; cl01172 485918017252 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 485918017253 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 485918017254 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918017255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918017256 active site 485918017257 phosphorylation site [posttranslational modification] 485918017258 intermolecular recognition site; other site 485918017259 dimerization interface [polypeptide binding]; other site 485918017260 LytTr DNA-binding domain; Region: LytTR; smart00850 485918017261 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918017262 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918017263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918017264 binding surface 485918017265 TPR motif; other site 485918017266 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918017267 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918017268 Histidine kinase; Region: His_kinase; pfam06580 485918017269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 485918017270 cytidylate kinase; Provisional; Region: cmk; PRK00023 485918017271 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 485918017272 CMP-binding site; other site 485918017273 The sites determining sugar specificity; other site 485918017274 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918017275 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 485918017276 Clp amino terminal domain; Region: Clp_N; pfam02861 485918017277 Clp amino terminal domain; Region: Clp_N; pfam02861 485918017278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918017279 Walker A motif; other site 485918017280 ATP binding site [chemical binding]; other site 485918017281 Walker B motif; other site 485918017282 arginine finger; other site 485918017283 UvrB/uvrC motif; Region: UVR; pfam02151 485918017284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918017285 Walker A motif; other site 485918017286 ATP binding site [chemical binding]; other site 485918017287 Walker B motif; other site 485918017288 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 485918017289 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 485918017290 anti sigma factor interaction site; other site 485918017291 regulatory phosphorylation site [posttranslational modification]; other site 485918017292 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 485918017293 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 485918017294 dihydrodipicolinate synthase; Region: dapA; TIGR00674 485918017295 dimer interface [polypeptide binding]; other site 485918017296 active site 485918017297 catalytic residue [active] 485918017298 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 485918017299 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 485918017300 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 485918017301 Tannase and feruloyl esterase; Region: Tannase; pfam07519 485918017302 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 485918017303 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 485918017304 Domain of unknown function (DUF1793); Region: DUF1793; pfam08760 485918017305 Alg9-like mannosyltransferase family; Region: Glyco_transf_22; cl17751 485918017306 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 485918017307 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 485918017308 NADH(P)-binding; Region: NAD_binding_10; pfam13460 485918017309 NAD binding site [chemical binding]; other site 485918017310 active site 485918017311 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 485918017312 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 485918017313 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918017314 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918017315 ligand binding site [chemical binding]; other site 485918017316 flexible hinge region; other site 485918017317 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 485918017318 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 485918017319 Surface antigen; Region: Bac_surface_Ag; pfam01103 485918017320 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 485918017321 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 485918017322 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 485918017323 active site 485918017324 metal binding site [ion binding]; metal-binding site 485918017325 PQQ-like domain; Region: PQQ_2; pfam13360 485918017326 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 485918017327 Trp docking motif [polypeptide binding]; other site 485918017328 active site 485918017329 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918017330 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918017331 SusD family; Region: SusD; pfam07980 485918017332 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918017333 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 485918017334 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918017335 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918017336 FecR protein; Region: FecR; pfam04773 485918017337 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918017338 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918017339 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918017340 DNA binding residues [nucleotide binding] 485918017341 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 485918017342 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 485918017343 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 485918017344 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 485918017345 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 485918017346 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918017347 DNA binding residues [nucleotide binding] 485918017348 Putative zinc-finger; Region: zf-HC2; pfam13490 485918017349 Uncharacterized conserved protein [Function unknown]; Region: COG1359 485918017350 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 485918017351 active site 485918017352 catalytic triad [active] 485918017353 oxyanion hole [active] 485918017354 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 485918017355 putative active site [active] 485918017356 catalytic site [active] 485918017357 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918017358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918017359 active site 485918017360 phosphorylation site [posttranslational modification] 485918017361 intermolecular recognition site; other site 485918017362 dimerization interface [polypeptide binding]; other site 485918017363 LytTr DNA-binding domain; Region: LytTR; smart00850 485918017364 Histidine kinase; Region: His_kinase; pfam06580 485918017365 Epoxide hydrolase N terminus; Region: EHN; pfam06441 485918017366 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918017367 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 485918017368 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 485918017369 putative NAD(P) binding site [chemical binding]; other site 485918017370 active site 485918017371 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918017372 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918017373 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918017374 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918017375 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918017376 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918017377 Sel1-like repeats; Region: SEL1; smart00671 485918017378 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 485918017379 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 485918017380 active site 485918017381 Zn binding site [ion binding]; other site 485918017382 RibD C-terminal domain; Region: RibD_C; cl17279 485918017383 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 485918017384 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918017385 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918017386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918017387 Major Facilitator Superfamily; Region: MFS_1; pfam07690 485918017388 putative substrate translocation pore; other site 485918017389 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 485918017390 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 485918017391 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 485918017392 DNA-binding site [nucleotide binding]; DNA binding site 485918017393 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 485918017394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918017395 homodimer interface [polypeptide binding]; other site 485918017396 catalytic residue [active] 485918017397 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 485918017398 classical (c) SDRs; Region: SDR_c; cd05233 485918017399 NAD(P) binding site [chemical binding]; other site 485918017400 active site 485918017401 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918017402 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918017403 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918017404 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918017405 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 485918017406 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 485918017407 active site 485918017408 catalytic tetrad [active] 485918017409 short chain dehydrogenase; Validated; Region: PRK06182 485918017410 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 485918017411 NADP binding site [chemical binding]; other site 485918017412 active site 485918017413 steroid binding site; other site 485918017414 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918017415 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918017416 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918017417 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918017418 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 485918017419 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 485918017420 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 485918017421 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918017422 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918017423 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 485918017424 ADP-ribose binding site [chemical binding]; other site 485918017425 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 485918017426 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918017427 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918017428 ligand binding site [chemical binding]; other site 485918017429 flexible hinge region; other site 485918017430 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918017431 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 485918017432 ligand binding site [chemical binding]; other site 485918017433 flexible hinge region; other site 485918017434 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 485918017435 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 485918017436 NAD(P) binding site [chemical binding]; other site 485918017437 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 485918017438 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 485918017439 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918017440 NAD(P) binding site [chemical binding]; other site 485918017441 active site 485918017442 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918017443 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 485918017444 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 485918017445 N-terminal plug; other site 485918017446 ligand-binding site [chemical binding]; other site 485918017447 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 485918017448 putative active site [active] 485918017449 catalytic site [active] 485918017450 putative metal binding site [ion binding]; other site 485918017451 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 485918017452 putative hydrophobic ligand binding site [chemical binding]; other site 485918017453 HPP family; Region: HPP; pfam04982 485918017454 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 485918017455 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 485918017456 active site 485918017457 catalytic tetrad [active] 485918017458 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918017459 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 485918017460 active site 485918017461 Family description; Region: VCBS; pfam13517 485918017462 Family description; Region: VCBS; pfam13517 485918017463 Family description; Region: VCBS; pfam13517 485918017464 Family description; Region: VCBS; pfam13517 485918017465 Family description; Region: VCBS; pfam13517 485918017466 Family description; Region: VCBS; pfam13517 485918017467 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 485918017468 Family description; Region: VCBS; pfam13517 485918017469 Family description; Region: VCBS; pfam13517 485918017470 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 485918017471 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918017472 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918017473 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918017474 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918017475 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918017476 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 485918017477 putative substrate binding site [chemical binding]; other site 485918017478 active site 485918017479 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918017480 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918017481 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918017482 DNA binding residues [nucleotide binding] 485918017483 FecR protein; Region: FecR; pfam04773 485918017484 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918017485 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918017486 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918017487 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918017488 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918017489 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 485918017490 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918017491 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 485918017492 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 485918017493 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 485918017494 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 485918017495 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 485918017496 active site 485918017497 catalytic residues [active] 485918017498 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918017499 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918017500 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918017501 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918017502 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918017503 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918017504 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918017505 FecR protein; Region: FecR; pfam04773 485918017506 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918017507 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918017508 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918017509 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 485918017510 DNA binding residues [nucleotide binding] 485918017511 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918017512 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 485918017513 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 485918017514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918017515 Major Facilitator Superfamily; Region: MFS_1; pfam07690 485918017516 putative substrate translocation pore; other site 485918017517 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918017518 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 485918017519 putative dimer interface [polypeptide binding]; other site 485918017520 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918017521 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918017522 binding surface 485918017523 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918017524 TPR motif; other site 485918017525 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918017526 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 485918017527 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918017528 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 485918017529 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 485918017530 active site 485918017531 catalytic tetrad [active] 485918017532 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 485918017533 Transcriptional regulator [Transcription]; Region: LysR; COG0583 485918017534 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 485918017535 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 485918017536 dimerization interface [polypeptide binding]; other site 485918017537 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918017538 FecR protein; Region: FecR; pfam04773 485918017539 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918017540 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918017541 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918017542 DNA binding residues [nucleotide binding] 485918017543 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 485918017544 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918017545 Coenzyme A binding pocket [chemical binding]; other site 485918017546 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918017547 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918017548 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918017549 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 485918017550 Zn2+ binding site [ion binding]; other site 485918017551 Mg2+ binding site [ion binding]; other site 485918017552 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 485918017553 dimerization interface [polypeptide binding]; other site 485918017554 putative DNA binding site [nucleotide binding]; other site 485918017555 putative Zn2+ binding site [ion binding]; other site 485918017556 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 485918017557 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 485918017558 catalytic loop [active] 485918017559 iron binding site [ion binding]; other site 485918017560 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 485918017561 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 485918017562 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 485918017563 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 485918017564 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 485918017565 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 485918017566 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 485918017567 XdhC Rossmann domain; Region: XdhC_C; pfam13478 485918017568 urate oxidase; Region: urate_oxi; TIGR03383 485918017569 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 485918017570 active site 485918017571 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 485918017572 allantoinase; Region: allantoinase; TIGR03178 485918017573 active site 485918017574 allantoate amidohydrolase; Reviewed; Region: PRK09290 485918017575 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 485918017576 active site 485918017577 metal binding site [ion binding]; metal-binding site 485918017578 dimer interface [polypeptide binding]; other site 485918017579 hypothetical protein; Provisional; Region: PRK11171 485918017580 Cupin domain; Region: Cupin_2; cl17218 485918017581 Cupin domain; Region: Cupin_2; pfam07883 485918017582 putative OHCU decarboxylase; Provisional; Region: PRK13798 485918017583 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 485918017584 active site 485918017585 homotetramer interface [polypeptide binding]; other site 485918017586 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 485918017587 KTSC domain; Region: KTSC; pfam13619 485918017588 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 485918017589 Beta-lactamase; Region: Beta-lactamase; pfam00144 485918017590 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 485918017591 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 485918017592 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 485918017593 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 485918017594 dimerization interface [polypeptide binding]; other site 485918017595 ligand binding site [chemical binding]; other site 485918017596 NADP binding site [chemical binding]; other site 485918017597 catalytic site [active] 485918017598 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 485918017599 active site triad [active] 485918017600 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 485918017601 substrate binding site [chemical binding]; other site 485918017602 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918017603 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918017604 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 485918017605 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 485918017606 Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576 485918017607 putative ligand binding site [chemical binding]; other site 485918017608 putative catalytic site [active] 485918017609 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918017610 Rhomboid family; Region: Rhomboid; pfam01694 485918017611 DinB family; Region: DinB; cl17821 485918017612 DinB superfamily; Region: DinB_2; pfam12867 485918017613 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 485918017614 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 485918017615 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 485918017616 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918017617 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918017618 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918017619 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 485918017620 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918017621 FecR protein; Region: FecR; pfam04773 485918017622 Protein of unknown function (DUF1410); Region: DUF1410; pfam07198 485918017623 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918017624 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918017625 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918017626 DNA binding residues [nucleotide binding] 485918017627 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918017628 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 485918017629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918017630 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918017631 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918017632 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918017633 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918017634 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918017635 SusD family; Region: SusD; pfam07980 485918017636 Fibronectin type 3 domain; Region: FN3; smart00060 485918017637 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 485918017638 classical (c) SDRs; Region: SDR_c; cd05233 485918017639 NAD(P) binding site [chemical binding]; other site 485918017640 active site 485918017641 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 485918017642 Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cl12263 485918017643 Domain of unknown function (DUF4421); Region: DUF4421; pfam14391 485918017644 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 485918017645 Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120 485918017646 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918017647 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918017648 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918017649 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918017650 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918017651 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918017652 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 485918017653 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 485918017654 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 485918017655 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 485918017656 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 485918017657 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 485918017658 putative active site [active] 485918017659 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 485918017660 Na binding site [ion binding]; other site 485918017661 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 485918017662 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 485918017663 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 485918017664 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 485918017665 NodB motif; other site 485918017666 active site 485918017667 catalytic site [active] 485918017668 metal binding site [ion binding]; metal-binding site 485918017669 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 485918017670 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 485918017671 putative catalytic cysteine [active] 485918017672 gamma-glutamyl kinase; Provisional; Region: PRK05429 485918017673 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 485918017674 nucleotide binding site [chemical binding]; other site 485918017675 homotetrameric interface [polypeptide binding]; other site 485918017676 putative phosphate binding site [ion binding]; other site 485918017677 putative allosteric binding site; other site 485918017678 PUA domain; Region: PUA; pfam01472 485918017679 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 485918017680 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 485918017681 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 485918017682 Histidine kinase; Region: HisKA_3; pfam07730 485918017683 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918017684 ATP binding site [chemical binding]; other site 485918017685 Mg2+ binding site [ion binding]; other site 485918017686 G-X-G motif; other site 485918017687 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 485918017688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918017689 active site 485918017690 phosphorylation site [posttranslational modification] 485918017691 intermolecular recognition site; other site 485918017692 dimerization interface [polypeptide binding]; other site 485918017693 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918017694 DNA binding residues [nucleotide binding] 485918017695 dimerization interface [polypeptide binding]; other site 485918017696 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 485918017697 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 485918017698 Transcriptional regulators [Transcription]; Region: PurR; COG1609 485918017699 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 485918017700 DNA binding site [nucleotide binding] 485918017701 domain linker motif; other site 485918017702 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 485918017703 dimerization interface [polypeptide binding]; other site 485918017704 ligand binding site [chemical binding]; other site 485918017705 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 485918017706 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 485918017707 NADP binding site [chemical binding]; other site 485918017708 homodimer interface [polypeptide binding]; other site 485918017709 active site 485918017710 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 485918017711 galactarate dehydratase; Region: galactar-dH20; TIGR03248 485918017712 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 485918017713 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 485918017714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918017715 Major Facilitator Superfamily; Region: MFS_1; pfam07690 485918017716 putative substrate translocation pore; other site 485918017717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918017718 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 485918017719 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 485918017720 active site 485918017721 intersubunit interface [polypeptide binding]; other site 485918017722 catalytic residue [active] 485918017723 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 485918017724 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 485918017725 substrate binding site [chemical binding]; other site 485918017726 ATP binding site [chemical binding]; other site 485918017727 Glucuronate isomerase; Region: UxaC; pfam02614 485918017728 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 485918017729 altronate oxidoreductase; Provisional; Region: PRK03643 485918017730 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 485918017731 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 485918017732 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 485918017733 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 485918017734 Ligand Binding Site [chemical binding]; other site 485918017735 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 485918017736 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 485918017737 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 485918017738 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 485918017739 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 485918017740 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 485918017741 E3 interaction surface; other site 485918017742 lipoyl attachment site [posttranslational modification]; other site 485918017743 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 485918017744 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 485918017745 E3 interaction surface; other site 485918017746 lipoyl attachment site [posttranslational modification]; other site 485918017747 e3 binding domain; Region: E3_binding; pfam02817 485918017748 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 485918017749 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 485918017750 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 485918017751 TPP-binding site [chemical binding]; other site 485918017752 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 485918017753 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 485918017754 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 485918017755 putative active site [active] 485918017756 Zn binding site [ion binding]; other site 485918017757 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 485918017758 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 485918017759 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 485918017760 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 485918017761 dimer interface [polypeptide binding]; other site 485918017762 active site 485918017763 Phosphopantetheine attachment site; Region: PP-binding; cl09936 485918017764 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 485918017765 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 485918017766 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 485918017767 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 485918017768 Walker A/P-loop; other site 485918017769 ATP binding site [chemical binding]; other site 485918017770 Q-loop/lid; other site 485918017771 ABC transporter signature motif; other site 485918017772 Walker B; other site 485918017773 D-loop; other site 485918017774 H-loop/switch region; other site 485918017775 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 485918017776 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 485918017777 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 485918017778 dimer interface [polypeptide binding]; other site 485918017779 active site 485918017780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918017781 S-adenosylmethionine binding site [chemical binding]; other site 485918017782 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 485918017783 GMP synthase; Reviewed; Region: guaA; PRK00074 485918017784 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 485918017785 AMP/PPi binding site [chemical binding]; other site 485918017786 candidate oxyanion hole; other site 485918017787 catalytic triad [active] 485918017788 potential glutamine specificity residues [chemical binding]; other site 485918017789 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 485918017790 ATP Binding subdomain [chemical binding]; other site 485918017791 Ligand Binding sites [chemical binding]; other site 485918017792 Dimerization subdomain; other site 485918017793 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 485918017794 ligand binding site [chemical binding]; other site 485918017795 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 485918017796 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 485918017797 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 485918017798 ATP-dependent DNA ligase; Validated; Region: PRK09247 485918017799 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 485918017800 active site 485918017801 DNA binding site [nucleotide binding] 485918017802 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 485918017803 DNA binding site [nucleotide binding] 485918017804 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 485918017805 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 485918017806 putative DNA binding site [nucleotide binding]; other site 485918017807 putative Zn2+ binding site [ion binding]; other site 485918017808 AsnC family; Region: AsnC_trans_reg; pfam01037 485918017809 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 485918017810 dimer interface [polypeptide binding]; other site 485918017811 catalytic triad [active] 485918017812 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 485918017813 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 485918017814 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 485918017815 ATP binding site [chemical binding]; other site 485918017816 putative Mg++ binding site [ion binding]; other site 485918017817 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 485918017818 nucleotide binding region [chemical binding]; other site 485918017819 ATP-binding site [chemical binding]; other site 485918017820 DEAD/H associated; Region: DEAD_assoc; pfam08494 485918017821 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 485918017822 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 485918017823 putative active site [active] 485918017824 putative metal binding site [ion binding]; other site 485918017825 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 485918017826 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 485918017827 putative active site [active] 485918017828 Zn binding site [ion binding]; other site 485918017829 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 485918017830 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 485918017831 non-specific DNA binding site [nucleotide binding]; other site 485918017832 salt bridge; other site 485918017833 sequence-specific DNA binding site [nucleotide binding]; other site 485918017834 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 485918017835 Catalytic site [active] 485918017836 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 485918017837 SdpI/YhfL protein family; Region: SdpI; pfam13630 485918017838 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 485918017839 active site 485918017840 DNA polymerase IV; Validated; Region: PRK02406 485918017841 DNA binding site [nucleotide binding] 485918017842 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 485918017843 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 485918017844 active site 485918017845 PHP Thumb interface [polypeptide binding]; other site 485918017846 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 485918017847 generic binding surface I; other site 485918017848 generic binding surface II; other site 485918017849 aspartate kinase III; Validated; Region: PRK09084 485918017850 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 485918017851 nucleotide binding site [chemical binding]; other site 485918017852 substrate binding site [chemical binding]; other site 485918017853 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 485918017854 dimer interface [polypeptide binding]; other site 485918017855 allosteric regulatory binding pocket; other site 485918017856 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 485918017857 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 485918017858 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 485918017859 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918017860 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918017861 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918017862 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918017863 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918017864 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 485918017865 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918017866 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918017867 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918017868 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918017869 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918017870 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 485918017871 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 485918017872 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 485918017873 Substrate-binding site [chemical binding]; other site 485918017874 Substrate specificity [chemical binding]; other site 485918017875 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 485918017876 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 485918017877 active site 485918017878 HIGH motif; other site 485918017879 dimer interface [polypeptide binding]; other site 485918017880 KMSKS motif; other site 485918017881 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 485918017882 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 485918017883 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 485918017884 Walker A/P-loop; other site 485918017885 ATP binding site [chemical binding]; other site 485918017886 Q-loop/lid; other site 485918017887 ABC transporter signature motif; other site 485918017888 Walker B; other site 485918017889 D-loop; other site 485918017890 H-loop/switch region; other site 485918017891 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 485918017892 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 485918017893 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 485918017894 Walker A/P-loop; other site 485918017895 ATP binding site [chemical binding]; other site 485918017896 Q-loop/lid; other site 485918017897 ABC transporter signature motif; other site 485918017898 Walker B; other site 485918017899 D-loop; other site 485918017900 H-loop/switch region; other site 485918017901 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 485918017902 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918017903 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 485918017904 NAD(P) binding site [chemical binding]; other site 485918017905 active site 485918017906 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 485918017907 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 485918017908 Walker A/P-loop; other site 485918017909 ATP binding site [chemical binding]; other site 485918017910 Q-loop/lid; other site 485918017911 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 485918017912 ABC transporter signature motif; other site 485918017913 Walker B; other site 485918017914 D-loop; other site 485918017915 H-loop/switch region; other site 485918017916 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918017917 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 485918017918 Putative zinc ribbon domain; Region: DUF164; pfam02591 485918017919 Uncharacterized conserved protein [Function unknown]; Region: COG0327 485918017920 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 485918017921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 485918017922 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 485918017923 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 485918017924 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 485918017925 active site 485918017926 Zn binding site [ion binding]; other site 485918017927 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 485918017928 active site residue [active] 485918017929 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 485918017930 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918017931 catalytic residues [active] 485918017932 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 485918017933 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 485918017934 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918017935 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 485918017936 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918017937 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918017938 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918017939 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918017940 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918017941 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918017942 PKD domain; Region: PKD; pfam00801 485918017943 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918017944 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 485918017945 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 485918017946 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 485918017947 dimer interface [polypeptide binding]; other site 485918017948 catalytic triad [active] 485918017949 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918017950 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 485918017951 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 485918017952 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 485918017953 putative RNA binding site [nucleotide binding]; other site 485918017954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918017955 S-adenosylmethionine binding site [chemical binding]; other site 485918017956 heat shock protein GrpE; Provisional; Region: PRK14140 485918017957 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 485918017958 dimer interface [polypeptide binding]; other site 485918017959 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 485918017960 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 485918017961 HSP70 interaction site [polypeptide binding]; other site 485918017962 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 485918017963 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 485918017964 Zn binding sites [ion binding]; other site 485918017965 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 485918017966 dimer interface [polypeptide binding]; other site 485918017967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918017968 S-adenosylmethionine binding site [chemical binding]; other site 485918017969 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918017970 von Willebrand factor; Region: vWF_A; pfam12450 485918017971 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 485918017972 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 485918017973 metal ion-dependent adhesion site (MIDAS); other site 485918017974 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 485918017975 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 485918017976 active site 485918017977 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 485918017978 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 485918017979 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 485918017980 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 485918017981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918017982 S-adenosylmethionine binding site [chemical binding]; other site 485918017983 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 485918017984 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 485918017985 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918017986 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918017987 FOG: PKD repeat [General function prediction only]; Region: COG3291 485918017988 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918017989 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918017990 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 485918017991 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 485918017992 generic binding surface II; other site 485918017993 ssDNA binding site; other site 485918017994 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 485918017995 ATP binding site [chemical binding]; other site 485918017996 putative Mg++ binding site [ion binding]; other site 485918017997 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 485918017998 nucleotide binding region [chemical binding]; other site 485918017999 ATP-binding site [chemical binding]; other site 485918018000 type I citrate synthase; Reviewed; Region: PRK09569 485918018001 citrate (Si)-synthase, eukaryotic; Region: cit_synth_euk; TIGR01793 485918018002 oxalacetate binding site [chemical binding]; other site 485918018003 citrylCoA binding site [chemical binding]; other site 485918018004 coenzyme A binding site [chemical binding]; other site 485918018005 catalytic triad [active] 485918018006 Predicted permeases [General function prediction only]; Region: COG0795 485918018007 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 485918018008 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 485918018009 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 485918018010 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 485918018011 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 485918018012 active site 485918018013 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 485918018014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918018015 S-adenosylmethionine binding site [chemical binding]; other site 485918018016 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 485918018017 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918018018 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918018019 DNA binding residues [nucleotide binding] 485918018020 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 485918018021 Zn binding site [ion binding]; other site 485918018022 Predicted methyltransferases [General function prediction only]; Region: COG0313 485918018023 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 485918018024 putative SAM binding site [chemical binding]; other site 485918018025 putative homodimer interface [polypeptide binding]; other site 485918018026 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 485918018027 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 485918018028 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 485918018029 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 485918018030 proline aminopeptidase P II; Provisional; Region: PRK10879 485918018031 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 485918018032 active site 485918018033 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 485918018034 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 485918018035 active site 485918018036 substrate-binding site [chemical binding]; other site 485918018037 metal-binding site [ion binding] 485918018038 ATP binding site [chemical binding]; other site 485918018039 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185 485918018040 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 485918018041 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 485918018042 homodimer interface [polypeptide binding]; other site 485918018043 NADP binding site [chemical binding]; other site 485918018044 substrate binding site [chemical binding]; other site 485918018045 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 485918018046 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 485918018047 FeS/SAM binding site; other site 485918018048 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918018049 TPR motif; other site 485918018050 binding surface 485918018051 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 485918018052 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 485918018053 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 485918018054 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 485918018055 ligand binding site [chemical binding]; other site 485918018056 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 485918018057 DNA protecting protein DprA; Region: dprA; TIGR00732 485918018058 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 485918018059 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 485918018060 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 485918018061 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 485918018062 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 485918018063 active site 485918018064 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 485918018065 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 485918018066 putative active site [active] 485918018067 catalytic triad [active] 485918018068 putative dimer interface [polypeptide binding]; other site 485918018069 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918018070 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 485918018071 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918018072 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918018073 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 485918018074 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 485918018075 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 485918018076 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 485918018077 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 485918018078 putative NAD(P) binding site [chemical binding]; other site 485918018079 homotetramer interface [polypeptide binding]; other site 485918018080 homodimer interface [polypeptide binding]; other site 485918018081 active site 485918018082 BNR repeat-like domain; Region: BNR_2; pfam13088 485918018083 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918018084 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 485918018085 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 485918018086 N-terminal plug; other site 485918018087 ligand-binding site [chemical binding]; other site 485918018088 cell surface protein SprA; Region: surface_SprA; TIGR04189 485918018089 Motility related/secretion protein; Region: SprA_N; pfam14349 485918018090 Motility related/secretion protein; Region: SprA_N; pfam14349 485918018091 Motility related/secretion protein; Region: SprA_N; pfam14349 485918018092 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 485918018093 RuvA N terminal domain; Region: RuvA_N; pfam01330 485918018094 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 485918018095 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 485918018096 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 485918018097 dimer interface [polypeptide binding]; other site 485918018098 active site 485918018099 CoA binding pocket [chemical binding]; other site 485918018100 Tetratricopeptide repeat; Region: TPR_12; pfam13424 485918018101 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918018102 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 485918018103 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918018104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 485918018105 dimer interface [polypeptide binding]; other site 485918018106 phosphorylation site [posttranslational modification] 485918018107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918018108 ATP binding site [chemical binding]; other site 485918018109 Mg2+ binding site [ion binding]; other site 485918018110 G-X-G motif; other site 485918018111 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 485918018112 nudix motif; other site 485918018113 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 485918018114 DinB family; Region: DinB; cl17821 485918018115 DinB superfamily; Region: DinB_2; pfam12867 485918018116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918018117 Coenzyme A binding pocket [chemical binding]; other site 485918018118 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 485918018119 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 485918018120 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 485918018121 homodecamer interface [polypeptide binding]; other site 485918018122 GTP cyclohydrolase I; Provisional; Region: PLN03044 485918018123 active site 485918018124 putative catalytic site residues [active] 485918018125 zinc binding site [ion binding]; other site 485918018126 GTP-CH-I/GFRP interaction surface; other site 485918018127 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 485918018128 active site 485918018129 futalosine nucleosidase; Region: fut_nucase; TIGR03664 485918018130 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 485918018131 DNA photolyase; Region: DNA_photolyase; pfam00875 485918018132 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 485918018133 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 485918018134 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 485918018135 homodimer interface [polypeptide binding]; other site 485918018136 substrate-cofactor binding pocket; other site 485918018137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 485918018138 catalytic residue [active] 485918018139 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 485918018140 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 485918018141 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 485918018142 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 485918018143 Flavoprotein; Region: Flavoprotein; pfam02441 485918018144 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 485918018145 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 485918018146 cell division protein MraZ; Reviewed; Region: PRK00326 485918018147 MraZ protein; Region: MraZ; pfam02381 485918018148 MraZ protein; Region: MraZ; pfam02381 485918018149 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 485918018150 MraW methylase family; Region: Methyltransf_5; cl17771 485918018151 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 485918018152 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 485918018153 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 485918018154 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 485918018155 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 485918018156 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 485918018157 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 485918018158 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 485918018159 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 485918018160 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 485918018161 Mg++ binding site [ion binding]; other site 485918018162 putative catalytic motif [active] 485918018163 putative substrate binding site [chemical binding]; other site 485918018164 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 485918018165 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 485918018166 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 485918018167 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 485918018168 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 485918018169 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 485918018170 homodimer interface [polypeptide binding]; other site 485918018171 active site 485918018172 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 485918018173 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 485918018174 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 485918018175 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 485918018176 cell division protein FtsA; Region: ftsA; TIGR01174 485918018177 Cell division protein FtsA; Region: FtsA; smart00842 485918018178 Cell division protein FtsA; Region: FtsA; pfam14450 485918018179 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 485918018180 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 485918018181 nucleotide binding site [chemical binding]; other site 485918018182 SulA interaction site; other site 485918018183 Domain of unknown function (DUF202); Region: DUF202; pfam02656 485918018184 Uncharacterized conserved protein [Function unknown]; Region: COG4748 485918018185 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 485918018186 Pirin-related protein [General function prediction only]; Region: COG1741 485918018187 Pirin; Region: Pirin; pfam02678 485918018188 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 485918018189 K+ potassium transporter; Region: K_trans; pfam02705 485918018190 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 485918018191 ligand binding site [chemical binding]; other site 485918018192 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 485918018193 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 485918018194 substrate binding pocket [chemical binding]; other site 485918018195 chain length determination region; other site 485918018196 substrate-Mg2+ binding site; other site 485918018197 catalytic residues [active] 485918018198 aspartate-rich region 1; other site 485918018199 active site lid residues [active] 485918018200 aspartate-rich region 2; other site 485918018201 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 485918018202 DHH family; Region: DHH; pfam01368 485918018203 DHHA1 domain; Region: DHHA1; pfam02272 485918018204 Predicted peptidase [General function prediction only]; Region: COG4099 485918018205 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918018206 heat shock protein 90; Provisional; Region: PRK05218 485918018207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918018208 ATP binding site [chemical binding]; other site 485918018209 Mg2+ binding site [ion binding]; other site 485918018210 G-X-G motif; other site 485918018211 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 485918018212 Bacterial Ig-like domain; Region: Big_5; pfam13205 485918018213 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 485918018214 putative catalytic site [active] 485918018215 putative metal binding site [ion binding]; other site 485918018216 putative phosphate binding site [ion binding]; other site 485918018217 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918018218 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 485918018219 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 485918018220 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 485918018221 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 485918018222 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 485918018223 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 485918018224 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 485918018225 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 485918018226 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 485918018227 active site 485918018228 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 485918018229 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme D-Threonine Aldolase; Region: PLPDE_III_D-TA; cd06821 485918018230 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 485918018231 dimer interface [polypeptide binding]; other site 485918018232 active site 485918018233 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 485918018234 substrate binding site [chemical binding]; other site 485918018235 catalytic residue [active] 485918018236 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 485918018237 homotrimer interaction site [polypeptide binding]; other site 485918018238 putative active site [active] 485918018239 fructuronate transporter; Provisional; Region: PRK10034; cl15264 485918018240 GntP family permease; Region: GntP_permease; pfam02447 485918018241 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918018242 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 485918018243 FtsX-like permease family; Region: FtsX; pfam02687 485918018244 Transcriptional regulators [Transcription]; Region: PurR; COG1609 485918018245 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 485918018246 DNA binding site [nucleotide binding] 485918018247 domain linker motif; other site 485918018248 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 485918018249 dimerization interface [polypeptide binding]; other site 485918018250 ligand binding site [chemical binding]; other site 485918018251 Phosphotransferase enzyme family; Region: APH; pfam01636 485918018252 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 485918018253 substrate binding site [chemical binding]; other site 485918018254 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 485918018255 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 485918018256 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 485918018257 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 485918018258 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 485918018259 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 485918018260 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 485918018261 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 485918018262 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 485918018263 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 485918018264 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 485918018265 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 485918018266 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 485918018267 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 485918018268 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 485918018269 catalytic loop [active] 485918018270 iron binding site [ion binding]; other site 485918018271 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 485918018272 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 485918018273 SLBB domain; Region: SLBB; pfam10531 485918018274 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 485918018275 NADH dehydrogenase subunit E; Validated; Region: PRK07539 485918018276 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 485918018277 putative dimer interface [polypeptide binding]; other site 485918018278 [2Fe-2S] cluster binding site [ion binding]; other site 485918018279 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 485918018280 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 485918018281 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 485918018282 NADH dehydrogenase subunit B; Provisional; Region: PRK14820 485918018283 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 485918018284 TPR repeat; Region: TPR_11; pfam13414 485918018285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918018286 binding surface 485918018287 TPR motif; other site 485918018288 PBP superfamily domain; Region: PBP_like_2; pfam12849 485918018289 Low molecular weight phosphatase family; Region: LMWPc; cd00115 485918018290 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 485918018291 active site 485918018292 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 485918018293 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 485918018294 dimer interface [polypeptide binding]; other site 485918018295 motif 1; other site 485918018296 active site 485918018297 motif 2; other site 485918018298 motif 3; other site 485918018299 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 485918018300 anticodon binding site; other site 485918018301 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 485918018302 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 485918018303 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 485918018304 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 485918018305 putative active site [active] 485918018306 catalytic triad [active] 485918018307 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 485918018308 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 485918018309 ligand binding site [chemical binding]; other site 485918018310 flexible hinge region; other site 485918018311 TPR repeat; Region: TPR_11; pfam13414 485918018312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918018313 binding surface 485918018314 TPR motif; other site 485918018315 Tetratricopeptide repeat; Region: TPR_16; pfam13432 485918018316 TPR repeat; Region: TPR_11; pfam13414 485918018317 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918018318 TPR motif; other site 485918018319 binding surface 485918018320 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 485918018321 active site 485918018322 DNA binding site [nucleotide binding] 485918018323 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 485918018324 active site 485918018325 Zn binding site [ion binding]; other site 485918018326 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 485918018327 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 485918018328 putative metal binding site [ion binding]; other site 485918018329 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 485918018330 active site 485918018331 Zn binding site [ion binding]; other site 485918018332 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 485918018333 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918018334 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918018335 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918018336 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918018337 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918018338 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918018339 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918018340 FecR protein; Region: FecR; pfam04773 485918018341 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918018342 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918018343 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918018344 DNA binding residues [nucleotide binding] 485918018345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918018346 TIGR01777 family protein; Region: yfcH 485918018347 NAD(P) binding site [chemical binding]; other site 485918018348 active site 485918018349 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 485918018350 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 485918018351 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 485918018352 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 485918018353 GDP-binding site [chemical binding]; other site 485918018354 ACT binding site; other site 485918018355 IMP binding site; other site 485918018356 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 485918018357 HD domain; Region: HD_4; pfam13328 485918018358 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 485918018359 synthetase active site [active] 485918018360 NTP binding site [chemical binding]; other site 485918018361 metal binding site [ion binding]; metal-binding site 485918018362 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 485918018363 ACT domain; Region: ACT_4; pfam13291 485918018364 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 485918018365 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 485918018366 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 485918018367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918018368 active site 485918018369 phosphorylation site [posttranslational modification] 485918018370 intermolecular recognition site; other site 485918018371 dimerization interface [polypeptide binding]; other site 485918018372 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 485918018373 DNA binding site [nucleotide binding] 485918018374 Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120 485918018375 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 485918018376 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 485918018377 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 485918018378 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 485918018379 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 485918018380 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 485918018381 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 485918018382 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 485918018383 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 485918018384 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918018385 Walker A/P-loop; other site 485918018386 ATP binding site [chemical binding]; other site 485918018387 Q-loop/lid; other site 485918018388 ABC transporter signature motif; other site 485918018389 Walker B; other site 485918018390 D-loop; other site 485918018391 H-loop/switch region; other site 485918018392 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 485918018393 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 485918018394 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 485918018395 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 485918018396 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 485918018397 substrate binding site [chemical binding]; other site 485918018398 oxyanion hole (OAH) forming residues; other site 485918018399 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 485918018400 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 485918018401 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 485918018402 Fic/DOC family; Region: Fic; pfam02661 485918018403 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 485918018404 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 485918018405 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 485918018406 active site 485918018407 HIGH motif; other site 485918018408 KMSKS motif; other site 485918018409 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 485918018410 tRNA binding surface [nucleotide binding]; other site 485918018411 anticodon binding site; other site 485918018412 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 485918018413 dimer interface [polypeptide binding]; other site 485918018414 putative tRNA-binding site [nucleotide binding]; other site 485918018415 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 485918018416 dimer interface [polypeptide binding]; other site 485918018417 catalytic triad [active] 485918018418 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 485918018419 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 485918018420 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 485918018421 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 485918018422 ATP binding site [chemical binding]; other site 485918018423 substrate interface [chemical binding]; other site 485918018424 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918018425 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918018426 dimer interface [polypeptide binding]; other site 485918018427 phosphorylation site [posttranslational modification] 485918018428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918018429 ATP binding site [chemical binding]; other site 485918018430 Mg2+ binding site [ion binding]; other site 485918018431 G-X-G motif; other site 485918018432 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 485918018433 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 485918018434 gamma subunit interface [polypeptide binding]; other site 485918018435 epsilon subunit interface [polypeptide binding]; other site 485918018436 LBP interface [polypeptide binding]; other site 485918018437 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 485918018438 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 485918018439 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 485918018440 alpha subunit interaction interface [polypeptide binding]; other site 485918018441 Walker A motif; other site 485918018442 ATP binding site [chemical binding]; other site 485918018443 Walker B motif; other site 485918018444 inhibitor binding site; inhibition site 485918018445 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 485918018446 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 485918018447 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 485918018448 Coenzyme A binding pocket [chemical binding]; other site 485918018449 Outer membrane efflux protein; Region: OEP; pfam02321 485918018450 Outer membrane efflux protein; Region: OEP; pfam02321 485918018451 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918018452 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 485918018453 FtsX-like permease family; Region: FtsX; pfam02687 485918018454 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918018455 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918018456 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 485918018457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918018458 dimer interface [polypeptide binding]; other site 485918018459 phosphorylation site [posttranslational modification] 485918018460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918018461 ATP binding site [chemical binding]; other site 485918018462 Mg2+ binding site [ion binding]; other site 485918018463 G-X-G motif; other site 485918018464 Response regulator receiver domain; Region: Response_reg; pfam00072 485918018465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918018466 active site 485918018467 phosphorylation site [posttranslational modification] 485918018468 intermolecular recognition site; other site 485918018469 dimerization interface [polypeptide binding]; other site 485918018470 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 485918018471 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14970 485918018472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918018473 Walker A motif; other site 485918018474 ATP binding site [chemical binding]; other site 485918018475 Walker B motif; other site 485918018476 arginine finger; other site 485918018477 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 485918018478 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 485918018479 E3 interaction surface; other site 485918018480 lipoyl attachment site [posttranslational modification]; other site 485918018481 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 485918018482 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 485918018483 E3 interaction surface; other site 485918018484 lipoyl attachment site [posttranslational modification]; other site 485918018485 e3 binding domain; Region: E3_binding; pfam02817 485918018486 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 485918018487 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 485918018488 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 485918018489 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 485918018490 dimerization interface [polypeptide binding]; other site 485918018491 putative DNA binding site [nucleotide binding]; other site 485918018492 putative Zn2+ binding site [ion binding]; other site 485918018493 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 485918018494 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 485918018495 putative NAD(P) binding site [chemical binding]; other site 485918018496 putative active site [active] 485918018497 CoA binding domain; Region: CoA_binding_2; pfam13380 485918018498 Protein of unknown function (DUF458); Region: DUF458; cl00861 485918018499 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 485918018500 G1 box; other site 485918018501 GTP/Mg2+ binding site [chemical binding]; other site 485918018502 Switch I region; other site 485918018503 G2 box; other site 485918018504 G3 box; other site 485918018505 Switch II region; other site 485918018506 G4 box; other site 485918018507 G5 box; other site 485918018508 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 485918018509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 485918018510 S-adenosylmethionine binding site [chemical binding]; other site 485918018511 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 485918018512 dihydroorotase; Reviewed; Region: PRK09236 485918018513 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 485918018514 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 485918018515 active site 485918018516 MutS domain III; Region: MutS_III; pfam05192 485918018517 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918018518 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 485918018519 Walker A/P-loop; other site 485918018520 ATP binding site [chemical binding]; other site 485918018521 Q-loop/lid; other site 485918018522 ABC transporter signature motif; other site 485918018523 Walker B; other site 485918018524 D-loop; other site 485918018525 H-loop/switch region; other site 485918018526 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 485918018527 RHS Repeat; Region: RHS_repeat; cl11982 485918018528 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 485918018529 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 485918018530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 485918018531 Walker A motif; other site 485918018532 ATP binding site [chemical binding]; other site 485918018533 Walker B motif; other site 485918018534 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 485918018535 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 485918018536 elongation factor G; Reviewed; Region: PRK12740 485918018537 G1 box; other site 485918018538 putative GEF interaction site [polypeptide binding]; other site 485918018539 GTP/Mg2+ binding site [chemical binding]; other site 485918018540 Switch I region; other site 485918018541 G2 box; other site 485918018542 G3 box; other site 485918018543 Switch II region; other site 485918018544 G4 box; other site 485918018545 G5 box; other site 485918018546 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 485918018547 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 485918018548 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 485918018549 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 485918018550 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 485918018551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918018552 Walker A/P-loop; other site 485918018553 ATP binding site [chemical binding]; other site 485918018554 Q-loop/lid; other site 485918018555 ABC transporter signature motif; other site 485918018556 Walker B; other site 485918018557 D-loop; other site 485918018558 H-loop/switch region; other site 485918018559 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918018560 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 485918018561 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 485918018562 N-terminal plug; other site 485918018563 ligand-binding site [chemical binding]; other site 485918018564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 485918018565 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 485918018566 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 485918018567 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 485918018568 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 485918018569 dimer interface [polypeptide binding]; other site 485918018570 active site 485918018571 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 485918018572 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 485918018573 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 485918018574 catalytic triad [active] 485918018575 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 485918018576 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 485918018577 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 485918018578 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918018579 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 485918018580 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918018581 methionine sulfoxide reductase A; Provisional; Region: PRK14054 485918018582 SelR domain; Region: SelR; pfam01641 485918018583 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 485918018584 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 485918018585 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 485918018586 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 485918018587 OsmC-like protein; Region: OsmC; cl00767 485918018588 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 485918018589 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 485918018590 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 485918018591 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 485918018592 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 485918018593 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 485918018594 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 485918018595 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 485918018596 catalytic residue [active] 485918018597 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 485918018598 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 485918018599 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918018600 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918018601 catalytic residues [active] 485918018602 putative deaminase; Validated; Region: PRK06846 485918018603 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 485918018604 active site 485918018605 Helix-turn-helix domain; Region: HTH_18; pfam12833 485918018606 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918018607 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 485918018608 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 485918018609 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 485918018610 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918018611 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918018612 DNA binding residues [nucleotide binding] 485918018613 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 485918018614 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 485918018615 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 485918018616 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918018617 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 485918018618 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918018619 Walker A/P-loop; other site 485918018620 ATP binding site [chemical binding]; other site 485918018621 ABC transporter signature motif; other site 485918018622 Walker B; other site 485918018623 D-loop; other site 485918018624 H-loop/switch region; other site 485918018625 ABC transporter; Region: ABC_tran_2; pfam12848 485918018626 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 485918018627 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 485918018628 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 485918018629 SnoaL-like domain; Region: SnoaL_2; pfam12680 485918018630 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 485918018631 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 485918018632 Haem-binding domain; Region: Haem_bd; pfam14376 485918018633 Histidine kinase; Region: His_kinase; pfam06580 485918018634 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918018635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918018636 active site 485918018637 phosphorylation site [posttranslational modification] 485918018638 intermolecular recognition site; other site 485918018639 dimerization interface [polypeptide binding]; other site 485918018640 LytTr DNA-binding domain; Region: LytTR; smart00850 485918018641 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 485918018642 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 485918018643 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 485918018644 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 485918018645 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 485918018646 active site 485918018647 catalytic tetrad [active] 485918018648 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 485918018649 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918018650 catalytic residues [active] 485918018651 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 485918018652 active site flap/lid [active] 485918018653 nucleophilic elbow; other site 485918018654 catalytic triad [active] 485918018655 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 485918018656 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 485918018657 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 485918018658 TROVE domain; Region: TROVE; pfam05731 485918018659 Domain of unknown function (DUF2828); Region: DUF2828; pfam11443 485918018660 Transmembrane secretion effector; Region: MFS_3; pfam05977 485918018661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918018662 putative substrate translocation pore; other site 485918018663 MarR family; Region: MarR_2; pfam12802 485918018664 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 485918018665 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 485918018666 hypothetical protein; Provisional; Region: PRK10030 485918018667 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 485918018668 TPR motif; other site 485918018669 TPR repeat; Region: TPR_11; pfam13414 485918018670 binding surface 485918018671 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 485918018672 putative catalytic site [active] 485918018673 putative metal binding site [ion binding]; other site 485918018674 putative phosphate binding site [ion binding]; other site 485918018675 DinB family; Region: DinB; cl17821 485918018676 DinB superfamily; Region: DinB_2; pfam12867 485918018677 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 485918018678 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 485918018679 metal ion-dependent adhesion site (MIDAS); other site 485918018680 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 485918018681 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 485918018682 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 485918018683 active site 485918018684 DNA polymerase IV; Validated; Region: PRK02406 485918018685 DNA binding site [nucleotide binding] 485918018686 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918018687 SusD family; Region: SusD; pfam07980 485918018688 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918018689 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918018690 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918018691 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918018692 DinB superfamily; Region: DinB_2; pfam12867 485918018693 DinB family; Region: DinB; cl17821 485918018694 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 485918018695 BNR repeat-like domain; Region: BNR_2; pfam13088 485918018696 catalytic site [active] 485918018697 Asp-box motif; other site 485918018698 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 485918018699 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918018700 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918018701 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918018702 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918018703 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918018704 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918018705 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918018706 FecR protein; Region: FecR; pfam04773 485918018707 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918018708 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918018709 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 485918018710 DNA binding residues [nucleotide binding] 485918018711 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 485918018712 Ferritin-like domain; Region: Ferritin; pfam00210 485918018713 ferroxidase diiron center [ion binding]; other site 485918018714 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 485918018715 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 485918018716 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 485918018717 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 485918018718 catalytic residues [active] 485918018719 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 485918018720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 485918018721 putative substrate translocation pore; other site 485918018722 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 485918018723 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 485918018724 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918018725 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918018726 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 485918018727 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 485918018728 active site 485918018729 catalytic tetrad [active] 485918018730 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 485918018731 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 485918018732 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 485918018733 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 485918018734 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 485918018735 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 485918018736 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 485918018737 Walker A/P-loop; other site 485918018738 ATP binding site [chemical binding]; other site 485918018739 Q-loop/lid; other site 485918018740 ABC transporter signature motif; other site 485918018741 Walker B; other site 485918018742 D-loop; other site 485918018743 H-loop/switch region; other site 485918018744 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 485918018745 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 485918018746 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 485918018747 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 485918018748 generic binding surface II; other site 485918018749 generic binding surface I; other site 485918018750 Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601 485918018751 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 485918018752 Outer membrane efflux protein; Region: OEP; pfam02321 485918018753 Outer membrane efflux protein; Region: OEP; pfam02321 485918018754 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 485918018755 HlyD family secretion protein; Region: HlyD_3; pfam13437 485918018756 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 485918018757 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 485918018758 CheB methylesterase; Region: CheB_methylest; pfam01339 485918018759 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 485918018760 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 485918018761 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 485918018762 PAS domain; Region: PAS_10; pfam13596 485918018763 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918018764 PAS fold; Region: PAS_3; pfam08447 485918018765 putative active site [active] 485918018766 heme pocket [chemical binding]; other site 485918018767 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 485918018768 PAS domain; Region: PAS_9; pfam13426 485918018769 putative active site [active] 485918018770 heme pocket [chemical binding]; other site 485918018771 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 485918018772 dimer interface [polypeptide binding]; other site 485918018773 phosphorylation site [posttranslational modification] 485918018774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 485918018775 ATP binding site [chemical binding]; other site 485918018776 Mg2+ binding site [ion binding]; other site 485918018777 G-X-G motif; other site 485918018778 PAS fold; Region: PAS_2; pfam08446 485918018779 GAF domain; Region: GAF; pfam01590 485918018780 Phytochrome region; Region: PHY; pfam00360 485918018781 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 485918018782 heme binding pocket [chemical binding]; other site 485918018783 heme ligand [chemical binding]; other site 485918018784 Response regulator receiver domain; Region: Response_reg; pfam00072 485918018785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918018786 active site 485918018787 phosphorylation site [posttranslational modification] 485918018788 intermolecular recognition site; other site 485918018789 dimerization interface [polypeptide binding]; other site 485918018790 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 485918018791 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 485918018792 Catalytic dyad [active] 485918018793 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 485918018794 glutamine synthetase; Region: PLN02284 485918018795 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 485918018796 HmuY protein; Region: HmuY; pfam14064 485918018797 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 485918018798 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 485918018799 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 485918018800 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 485918018801 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 485918018802 N-terminal plug; other site 485918018803 ligand-binding site [chemical binding]; other site 485918018804 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 485918018805 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 485918018806 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 485918018807 N-terminal plug; other site 485918018808 ligand-binding site [chemical binding]; other site 485918018809 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 485918018810 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 485918018811 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 485918018812 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 485918018813 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 485918018814 Walker A/P-loop; other site 485918018815 ATP binding site [chemical binding]; other site 485918018816 Q-loop/lid; other site 485918018817 ABC transporter signature motif; other site 485918018818 Walker B; other site 485918018819 D-loop; other site 485918018820 H-loop/switch region; other site 485918018821 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 485918018822 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 485918018823 ABC-ATPase subunit interface; other site 485918018824 dimer interface [polypeptide binding]; other site 485918018825 putative PBP binding regions; other site 485918018826 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 485918018827 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 485918018828 putative hemin binding site; other site 485918018829 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 485918018830 Secretin and TonB N terminus short domain; Region: STN; pfam07660 485918018831 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918018832 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918018833 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 485918018834 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918018835 FecR protein; Region: FecR; pfam04773 485918018836 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918018837 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918018838 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 485918018839 DNA binding residues [nucleotide binding] 485918018840 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 485918018841 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 485918018842 quinone interaction residues [chemical binding]; other site 485918018843 active site 485918018844 catalytic residues [active] 485918018845 FMN binding site [chemical binding]; other site 485918018846 substrate binding site [chemical binding]; other site 485918018847 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 485918018848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 485918018849 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 485918018850 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918018851 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918018852 SusD family; Region: SusD; pfam07980 485918018853 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918018854 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918018855 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918018856 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 485918018857 FecR protein; Region: FecR; pfam04773 485918018858 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 485918018859 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 485918018860 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 485918018861 DNA binding residues [nucleotide binding] 485918018862 RNA methyltransferase, RsmE family; Region: TIGR00046 485918018863 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 485918018864 multidrug efflux protein; Reviewed; Region: PRK01766 485918018865 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 485918018866 cation binding site [ion binding]; other site 485918018867 replicative DNA helicase; Region: DnaB; TIGR00665 485918018868 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 485918018869 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 485918018870 Walker A motif; other site 485918018871 ATP binding site [chemical binding]; other site 485918018872 Walker B motif; other site 485918018873 DNA binding loops [nucleotide binding] 485918018874 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 485918018875 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 485918018876 putative tRNA-binding site [nucleotide binding]; other site 485918018877 B3/4 domain; Region: B3_4; pfam03483 485918018878 tRNA synthetase B5 domain; Region: B5; smart00874 485918018879 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 485918018880 dimer interface [polypeptide binding]; other site 485918018881 motif 1; other site 485918018882 motif 3; other site 485918018883 motif 2; other site 485918018884 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 485918018885 Cell division protein ZapA; Region: ZapA; pfam05164 485918018886 phosphodiesterase; Provisional; Region: PRK12704 485918018887 KH domain; Region: KH_1; pfam00013 485918018888 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 485918018889 Zn2+ binding site [ion binding]; other site 485918018890 Mg2+ binding site [ion binding]; other site 485918018891 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 485918018892 purine nucleoside phosphorylase; Provisional; Region: PRK08202 485918018893 Predicted transcriptional regulators [Transcription]; Region: COG1733 485918018894 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 485918018895 dimerization interface [polypeptide binding]; other site 485918018896 putative DNA binding site [nucleotide binding]; other site 485918018897 putative Zn2+ binding site [ion binding]; other site 485918018898 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 485918018899 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 485918018900 NAD(P) binding site [chemical binding]; other site 485918018901 active site 485918018902 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 485918018903 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 485918018904 core domain interface [polypeptide binding]; other site 485918018905 delta subunit interface [polypeptide binding]; other site 485918018906 epsilon subunit interface [polypeptide binding]; other site 485918018907 intracellular protease, PfpI family; Region: PfpI; TIGR01382 485918018908 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 485918018909 conserved cys residue [active] 485918018910 starch binding outer membrane protein SusD; Region: SusD; cd08977 485918018911 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918018912 SusD family; Region: SusD; pfam07980 485918018913 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918018914 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918018915 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918018916 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 485918018917 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 485918018918 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 485918018919 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 485918018920 Protein of unknown function (DUF419); Region: DUF419; pfam04237 485918018921 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918018922 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 485918018923 FtsX-like permease family; Region: FtsX; pfam02687 485918018924 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 485918018925 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 485918018926 FtsX-like permease family; Region: FtsX; pfam02687 485918018927 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 485918018928 Uncharacterized conserved protein [Function unknown]; Region: COG3379 485918018929 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 485918018930 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198 485918018931 active site 485918018932 metal binding site [ion binding]; metal-binding site 485918018933 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; COG0382 485918018934 UbiA prenyltransferase family; Region: UbiA; pfam01040 485918018935 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 485918018936 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 485918018937 active site 485918018938 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 485918018939 L11 interface [polypeptide binding]; other site 485918018940 putative EF-Tu interaction site [polypeptide binding]; other site 485918018941 putative EF-G interaction site [polypeptide binding]; other site 485918018942 Family description; Region: VCBS; pfam13517 485918018943 Family description; Region: VCBS; pfam13517 485918018944 Family description; Region: VCBS; pfam13517 485918018945 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 485918018946 starch binding outer membrane protein SusD; Region: SusD; cl17845 485918018947 SusD family; Region: SusD; pfam07980 485918018948 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 485918018949 Cna protein B-type domain; Region: Cna_B_2; pfam13715 485918018950 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 485918018951 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 485918018952 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 485918018953 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 485918018954 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 485918018955 Trehalose utilisation; Region: ThuA; pfam06283 485918018956 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 485918018957 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 485918018958 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 485918018959 Cytochrome c; Region: Cytochrom_C; cl11414 485918018960 Trehalose utilisation; Region: ThuA; pfam06283 485918018961 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 485918018962 Cytochrome c; Region: Cytochrom_C; cl11414 485918018963 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 485918018964 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 485918018965 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 485918018966 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 485918018967 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 485918018968 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 485918018969 Ligand binding site; other site 485918018970 Putative Catalytic site; other site 485918018971 DXD motif; other site 485918018972 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 485918018973 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 485918018974 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 485918018975 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 485918018976 nucleotide binding region [chemical binding]; other site 485918018977 ATP-binding site [chemical binding]; other site 485918018978 SEC-C motif; Region: SEC-C; pfam02810 485918018979 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 485918018980 intersubunit interface [polypeptide binding]; other site 485918018981 active site 485918018982 catalytic residue [active] 485918018983 Sporulation related domain; Region: SPOR; pfam05036 485918018984 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 485918018985 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 485918018986 metal binding site [ion binding]; metal-binding site 485918018987 dimer interface [polypeptide binding]; other site 485918018988 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 485918018989 DNA-binding site [nucleotide binding]; DNA binding site 485918018990 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 485918018991 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 485918018992 Walker A/P-loop; other site 485918018993 ATP binding site [chemical binding]; other site 485918018994 Q-loop/lid; other site 485918018995 ABC transporter signature motif; other site 485918018996 Walker B; other site 485918018997 D-loop; other site 485918018998 H-loop/switch region; other site 485918018999 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 485918019000 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 485918019001 dimer interface [polypeptide binding]; other site 485918019002 active site 485918019003 glycine-pyridoxal phosphate binding site [chemical binding]; other site 485918019004 folate binding site [chemical binding]; other site 485918019005 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 485918019006 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 485918019007 active site 485918019008 Substrate binding site; other site 485918019009 Mg++ binding site; other site 485918019010 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 485918019011 putative trimer interface [polypeptide binding]; other site 485918019012 putative CoA binding site [chemical binding]; other site 485918019013 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 485918019014 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 485918019015 FMN binding site [chemical binding]; other site 485918019016 substrate binding site [chemical binding]; other site 485918019017 putative catalytic residue [active] 485918019018 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 485918019019 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 485918019020 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 485918019021 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 485918019022 Walker A/P-loop; other site 485918019023 ATP binding site [chemical binding]; other site 485918019024 Q-loop/lid; other site 485918019025 ABC transporter signature motif; other site 485918019026 Walker B; other site 485918019027 D-loop; other site 485918019028 H-loop/switch region; other site 485918019029 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 485918019030 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 485918019031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 485918019032 active site 485918019033 phosphorylation site [posttranslational modification] 485918019034 intermolecular recognition site; other site 485918019035 dimerization interface [polypeptide binding]; other site 485918019036 LytTr DNA-binding domain; Region: LytTR; smart00850 485918019037 Histidine kinase; Region: His_kinase; pfam06580 485918019038 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 485918019039 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 485918019040 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 485918019041 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325