-- dump date   	20140619_031047
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
243161000001	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
243161000002	active site
243161000003	Int/Topo IB signature motif; other site
243161000004	catalytic residues [active]
243161000005	DNA binding site [nucleotide binding]
243161000006	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
243161000007	active site
243161000008	catalytic residues [active]
243161000009	DNA binding site [nucleotide binding]
243161000010	Int/Topo IB signature motif; other site
243161000011	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
243161000012	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
243161000013	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
243161000014	Walker A motif; other site
243161000015	ATP binding site [chemical binding]; other site
243161000016	Walker B motif; other site
243161000017	DNA binding loops [nucleotide binding]
243161000018	Chlamydia virulence protein PGP3-D; Region: Chlam_vir; pfam05475
243161000019	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
243161000020	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
243161000021	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
243161000022	P-loop; other site
243161000023	Magnesium ion binding site [ion binding]; other site
243161000024	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
243161000025	Magnesium ion binding site [ion binding]; other site
243161000026	Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677
243161000027	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
243161000028	dimer interface [polypeptide binding]; other site
243161000029	active site
243161000030	aspartate-rich active site metal binding site; other site
243161000031	allosteric magnesium binding site [ion binding]; other site
243161000032	Schiff base residues; other site
243161000033	NADH:ubiquinone oxidoreductase, Na(+)-translocating, A subunit; Region: nqrA; TIGR01936
243161000034	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
243161000035	transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330
243161000036	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
243161000037	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
243161000038	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
243161000039	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243161000040	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243161000041	homodimer interface [polypeptide binding]; other site
243161000042	catalytic residue [active]
243161000043	rod shape-determining protein MreC; Provisional; Region: PRK14872
243161000044	rod shape-determining protein MreC; Region: MreC; pfam04085
243161000045	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
243161000046	Part of AAA domain; Region: AAA_19; pfam13245
243161000047	Family description; Region: UvrD_C_2; pfam13538
243161000048	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
243161000049	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
243161000050	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243161000051	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243161000052	putative substrate translocation pore; other site
243161000053	DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319
243161000054	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
243161000055	active site
243161000056	interdomain interaction site; other site
243161000057	putative metal-binding site [ion binding]; other site
243161000058	nucleotide binding site [chemical binding]; other site
243161000059	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
243161000060	domain I; other site
243161000061	DNA binding groove [nucleotide binding]
243161000062	phosphate binding site [ion binding]; other site
243161000063	domain II; other site
243161000064	domain III; other site
243161000065	nucleotide binding site [chemical binding]; other site
243161000066	catalytic site [active]
243161000067	domain IV; other site
243161000068	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
243161000069	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
243161000070	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
243161000071	SWIB/MDM2 domain; Region: SWIB; pfam02201
243161000072	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
243161000073	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
243161000074	FMN binding site [chemical binding]; other site
243161000075	active site
243161000076	catalytic residues [active]
243161000077	substrate binding site [chemical binding]; other site
243161000078	Predicted integral membrane protein [Function unknown]; Region: COG0762
243161000079	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
243161000080	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
243161000081	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
243161000082	recombinase A; Provisional; Region: recA; PRK09354
243161000083	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
243161000084	hexamer interface [polypeptide binding]; other site
243161000085	Walker A motif; other site
243161000086	ATP binding site [chemical binding]; other site
243161000087	Walker B motif; other site
243161000088	Protein of unknown function (DUF1347); Region: DUF1347; pfam07079
243161000089	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
243161000090	AAA domain; Region: AAA_30; pfam13604
243161000091	Family description; Region: UvrD_C_2; pfam13538
243161000092	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
243161000093	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
243161000094	Walker A/P-loop; other site
243161000095	ATP binding site [chemical binding]; other site
243161000096	Q-loop/lid; other site
243161000097	ABC transporter signature motif; other site
243161000098	Walker B; other site
243161000099	D-loop; other site
243161000100	H-loop/switch region; other site
243161000101	Protein of unknown function (DUF1137); Region: DUF1137; pfam06587
243161000102	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877
243161000103	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
243161000104	hypothetical protein; Provisional; Region: PRK01064
243161000105	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
243161000106	DNA topoisomerase IV subunit A; Provisional; Region: PRK09630
243161000107	DNA Topoisomerase IV; Region: TOP4c; smart00434
243161000108	CAP-like domain; other site
243161000109	active site
243161000110	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
243161000111	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243161000112	ATP binding site [chemical binding]; other site
243161000113	Mg2+ binding site [ion binding]; other site
243161000114	G-X-G motif; other site
243161000115	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783
243161000116	ATP binding site [chemical binding]; other site
243161000117	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
243161000118	active site
243161000119	putative metal-binding site [ion binding]; other site
243161000120	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
243161000121	glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676
243161000122	Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201
243161000123	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
243161000124	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
243161000125	phosphopeptide binding site; other site
243161000126	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
243161000127	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
243161000128	phosphopeptide binding site; other site
243161000129	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
243161000130	binding surface
243161000131	TPR motif; other site
243161000132	type III secretion system ATPase; Provisional; Region: PRK06315
243161000133	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
243161000134	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
243161000135	Walker A motif/ATP binding site; other site
243161000136	Walker B motif; other site
243161000137	type III secretion system protein; Validated; Region: PRK05933
243161000138	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
243161000139	Catalytic domain of Protein Kinases; Region: PKc; cd00180
243161000140	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
243161000141	active site
243161000142	ATP binding site [chemical binding]; other site
243161000143	substrate binding site [chemical binding]; other site
243161000144	activation loop (A-loop); other site
243161000145	Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450
243161000146	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
243161000147	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
243161000148	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
243161000149	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
243161000150	Arginine kinase [Amino acid transport and metabolism]; Region: COG3869
243161000151	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
243161000152	ADP binding site [chemical binding]; other site
243161000153	phosphagen binding site; other site
243161000154	substrate specificity loop; other site
243161000155	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
243161000156	Herpesvirus UL46 protein; Region: Herpes_UL46; cl17368
243161000157	UvrB/uvrC motif; Region: UVR; pfam02151
243161000158	ribosome recycling factor; Reviewed; Region: frr; PRK00083
243161000159	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
243161000160	hinge region; other site
243161000161	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
243161000162	putative nucleotide binding site [chemical binding]; other site
243161000163	uridine monophosphate binding site [chemical binding]; other site
243161000164	homohexameric interface [polypeptide binding]; other site
243161000165	Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]; Region: Tsf; COG0264
243161000166	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
243161000167	Elongation factor TS; Region: EF_TS; pfam00889
243161000168	Elongation factor TS; Region: EF_TS; pfam00889
243161000169	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
243161000170	rRNA interaction site [nucleotide binding]; other site
243161000171	S8 interaction site; other site
243161000172	putative laminin-1 binding site; other site
243161000173	Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308
243161000174	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
243161000175	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
243161000176	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
243161000177	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
243161000178	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243161000179	TPR motif; other site
243161000180	Tetratricopeptide repeat; Region: TPR_16; pfam13432
243161000181	binding surface
243161000182	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243161000183	binding surface
243161000184	TPR motif; other site
243161000185	TPR repeat; Region: TPR_11; pfam13414
243161000186	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243161000187	binding surface
243161000188	TPR repeat; Region: TPR_11; pfam13414
243161000189	TPR motif; other site
243161000190	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
243161000191	putative ABC transporter; Region: ycf24; CHL00085
243161000192	FeS assembly ATPase SufC; Region: sufC; TIGR01978
243161000193	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
243161000194	Walker A/P-loop; other site
243161000195	ATP binding site [chemical binding]; other site
243161000196	Q-loop/lid; other site
243161000197	ABC transporter signature motif; other site
243161000198	Walker B; other site
243161000199	D-loop; other site
243161000200	H-loop/switch region; other site
243161000201	FeS assembly protein SufD; Region: sufD; TIGR01981
243161000202	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
243161000203	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
243161000204	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
243161000205	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243161000206	catalytic residue [active]
243161000207	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
243161000208	ParB-like nuclease domain; Region: ParBc; pfam02195
243161000209	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
243161000210	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
243161000211	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
243161000212	Walker A/P-loop; other site
243161000213	ATP binding site [chemical binding]; other site
243161000214	Q-loop/lid; other site
243161000215	ABC transporter signature motif; other site
243161000216	Walker B; other site
243161000217	D-loop; other site
243161000218	H-loop/switch region; other site
243161000219	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
243161000220	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
243161000221	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
243161000222	Walker A/P-loop; other site
243161000223	ATP binding site [chemical binding]; other site
243161000224	Q-loop/lid; other site
243161000225	ABC transporter signature motif; other site
243161000226	Walker B; other site
243161000227	D-loop; other site
243161000228	H-loop/switch region; other site
243161000229	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
243161000230	Protein of unknown function DUF47; Region: PhoU_div; pfam01865
243161000231	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
243161000232	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
243161000233	Phosphoglycerate kinase; Region: PGK; pfam00162
243161000234	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
243161000235	substrate binding site [chemical binding]; other site
243161000236	hinge regions; other site
243161000237	ADP binding site [chemical binding]; other site
243161000238	catalytic site [active]
243161000239	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
243161000240	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
243161000241	minor groove reading motif; other site
243161000242	helix-hairpin-helix signature motif; other site
243161000243	substrate binding pocket [chemical binding]; other site
243161000244	active site
243161000245	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
243161000246	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
243161000247	trmE is a tRNA modification GTPase; Region: trmE; cd04164
243161000248	G1 box; other site
243161000249	GTP/Mg2+ binding site [chemical binding]; other site
243161000250	Switch I region; other site
243161000251	G2 box; other site
243161000252	Switch II region; other site
243161000253	G3 box; other site
243161000254	G4 box; other site
243161000255	G5 box; other site
243161000256	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
243161000257	phosphatidylserine decarboxylase; Provisional; Region: PRK00723
243161000258	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243161000259	binding surface
243161000260	TPR motif; other site
243161000261	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899
243161000262	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
243161000263	ATP binding site [chemical binding]; other site
243161000264	putative Mg++ binding site [ion binding]; other site
243161000265	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
243161000266	GTP-binding protein Der; Reviewed; Region: PRK00093
243161000267	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
243161000268	G1 box; other site
243161000269	GTP/Mg2+ binding site [chemical binding]; other site
243161000270	Switch I region; other site
243161000271	G2 box; other site
243161000272	Switch II region; other site
243161000273	G3 box; other site
243161000274	G4 box; other site
243161000275	G5 box; other site
243161000276	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
243161000277	G1 box; other site
243161000278	GTP/Mg2+ binding site [chemical binding]; other site
243161000279	Switch I region; other site
243161000280	G2 box; other site
243161000281	G3 box; other site
243161000282	Switch II region; other site
243161000283	G4 box; other site
243161000284	G5 box; other site
243161000285	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
243161000286	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
243161000287	active site
243161000288	NTP binding site [chemical binding]; other site
243161000289	metal binding triad [ion binding]; metal-binding site
243161000290	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
243161000291	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
243161000292	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
243161000293	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243161000294	Walker A motif; other site
243161000295	ATP binding site [chemical binding]; other site
243161000296	Walker B motif; other site
243161000297	arginine finger; other site
243161000298	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
243161000299	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
243161000300	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
243161000301	oligomer interface [polypeptide binding]; other site
243161000302	active site residues [active]
243161000303	FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544
243161000304	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
243161000305	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
243161000306	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
243161000307	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243161000308	ATP binding site [chemical binding]; other site
243161000309	putative Mg++ binding site [ion binding]; other site
243161000310	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243161000311	nucleotide binding region [chemical binding]; other site
243161000312	ATP-binding site [chemical binding]; other site
243161000313	rod shape-determining protein MreB; Provisional; Region: PRK13927
243161000314	MreB and similar proteins; Region: MreB_like; cd10225
243161000315	nucleotide binding site [chemical binding]; other site
243161000316	Mg binding site [ion binding]; other site
243161000317	putative protofilament interaction site [polypeptide binding]; other site
243161000318	RodZ interaction site [polypeptide binding]; other site
243161000319	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
243161000320	active site
243161000321	substrate-binding site [chemical binding]; other site
243161000322	metal-binding site [ion binding]
243161000323	GTP binding site [chemical binding]; other site
243161000324	Effector from type III secretion system; Region: Effector_1; pfam04518
243161000325	Effector from type III secretion system; Region: Effector_1; pfam04518
243161000326	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
243161000327	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
243161000328	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
243161000329	UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284
243161000330	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
243161000331	active site
243161000332	type III secretion system ATPase; Validated; Region: PRK05922
243161000333	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
243161000334	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
243161000335	Walker A motif; other site
243161000336	ATP binding site [chemical binding]; other site
243161000337	Walker B motif; other site
243161000338	type III secretion system protein; Validated; Region: PRK05934
243161000339	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
243161000340	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
243161000341	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
243161000342	active site
243161000343	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
243161000344	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
243161000345	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
243161000346	catalytic core [active]
243161000347	biotin--protein ligase; Provisional; Region: PRK05935
243161000348	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
243161000349	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
243161000350	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
243161000351	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
243161000352	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243161000353	motif II; other site
243161000354	CCC1-related protein family; Region: CCC1_like_1; cd02437
243161000355	seryl-tRNA synthetase; Provisional; Region: PRK05431
243161000356	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
243161000357	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
243161000358	dimer interface [polypeptide binding]; other site
243161000359	active site
243161000360	motif 1; other site
243161000361	motif 2; other site
243161000362	motif 3; other site
243161000363	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
243161000364	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
243161000365	catalytic motif [active]
243161000366	Zn binding site [ion binding]; other site
243161000367	RibD C-terminal domain; Region: RibD_C; pfam01872
243161000368	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
243161000369	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
243161000370	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
243161000371	dimerization interface [polypeptide binding]; other site
243161000372	active site
243161000373	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
243161000374	homopentamer interface [polypeptide binding]; other site
243161000375	active site
243161000376	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
243161000377	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
243161000378	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
243161000379	substrate binding site [chemical binding]; other site
243161000380	Proteins containing SET domain [General function prediction only]; Region: COG2940
243161000381	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317
243161000382	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
243161000383	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
243161000384	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
243161000385	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
243161000386	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
243161000387	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Region: NqrF; COG2871
243161000388	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
243161000389	catalytic loop [active]
243161000390	iron binding site [ion binding]; other site
243161000391	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
243161000392	FAD binding pocket [chemical binding]; other site
243161000393	FAD binding motif [chemical binding]; other site
243161000394	phosphate binding motif [ion binding]; other site
243161000395	beta-alpha-beta structure motif; other site
243161000396	NAD binding pocket [chemical binding]; other site
243161000397	preprotein translocase, YajC subunit; Region: yajC; TIGR00739
243161000398	Histone H1-like protein Hc1; Region: Hc1; pfam07432
243161000399	Tetratricopeptide repeat; Region: TPR_12; pfam13424
243161000400	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
243161000401	binding surface
243161000402	TPR motif; other site
243161000403	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
243161000404	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
243161000405	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
243161000406	HemN C-terminal domain; Region: HemN_C; pfam06969
243161000407	uroporphyrinogen decarboxylase; Region: hemE; TIGR01464
243161000408	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
243161000409	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
243161000410	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243161000411	ATP binding site [chemical binding]; other site
243161000412	putative Mg++ binding site [ion binding]; other site
243161000413	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243161000414	nucleotide binding region [chemical binding]; other site
243161000415	ATP-binding site [chemical binding]; other site
243161000416	TRCF domain; Region: TRCF; pfam03461
243161000417	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
243161000418	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
243161000419	motif 1; other site
243161000420	active site
243161000421	motif 2; other site
243161000422	motif 3; other site
243161000423	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
243161000424	DHHA1 domain; Region: DHHA1; pfam02272
243161000425	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
243161000426	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
243161000427	TPP-binding site [chemical binding]; other site
243161000428	dimer interface [polypeptide binding]; other site
243161000429	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
243161000430	PYR/PP interface [polypeptide binding]; other site
243161000431	dimer interface [polypeptide binding]; other site
243161000432	TPP binding site [chemical binding]; other site
243161000433	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
243161000434	AMP nucleosidase, putative; Region: AMN-like; TIGR01721
243161000435	elongation factor P; Validated; Region: PRK00529
243161000436	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
243161000437	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
243161000438	RNA binding site [nucleotide binding]; other site
243161000439	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
243161000440	RNA binding site [nucleotide binding]; other site
243161000441	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
243161000442	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
243161000443	active site
243161000444	metal binding site [ion binding]; metal-binding site
243161000445	Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459
243161000446	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
243161000447	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
243161000448	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
243161000449	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
243161000450	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
243161000451	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
243161000452	Mg++ binding site [ion binding]; other site
243161000453	putative catalytic motif [active]
243161000454	putative substrate binding site [chemical binding]; other site
243161000455	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683
243161000456	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
243161000457	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
243161000458	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
243161000459	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243161000460	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243161000461	cell division protein FtsW; Region: ftsW; TIGR02614
243161000462	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133
243161000463	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
243161000464	active site
243161000465	homodimer interface [polypeptide binding]; other site
243161000466	bifunctional D-alanyl-alanine synthetase A/UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: PRK14573
243161000467	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
243161000468	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
243161000469	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
243161000470	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
243161000471	ATP-grasp domain; Region: ATP-grasp_4; cl17255
243161000472	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
243161000473	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cd02409
243161000474	G-X-X-G motif; other site
243161000475	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
243161000476	anti sigma factor interaction site; other site
243161000477	regulatory phosphorylation site [posttranslational modification]; other site
243161000478	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
243161000479	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
243161000480	hypothetical protein; Provisional; Region: PRK05927
243161000481	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243161000482	FeS/SAM binding site; other site
243161000483	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
243161000484	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333
243161000485	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
243161000486	dimer interface [polypeptide binding]; other site
243161000487	active site
243161000488	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428
243161000489	active site
243161000490	Ap4A binding cleft/pocket [chemical binding]; other site
243161000491	P4 phosphate binding site; other site
243161000492	nudix motif; other site
243161000493	putative P2/P3 phosphate binding site [ion binding]; other site
243161000494	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
243161000495	dimer interface [polypeptide binding]; other site
243161000496	substrate binding site [chemical binding]; other site
243161000497	metal binding sites [ion binding]; metal-binding site
243161000498	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
243161000499	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
243161000500	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
243161000501	NAD binding site [chemical binding]; other site
243161000502	Phe binding site; other site
243161000503	PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517
243161000504	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
243161000505	active site
243161000506	putative lithium-binding site [ion binding]; other site
243161000507	substrate binding site [chemical binding]; other site
243161000508	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
243161000509	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
243161000510	putative acyl-acceptor binding pocket; other site
243161000511	long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334
243161000512	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
243161000513	acyl-activating enzyme (AAE) consensus motif; other site
243161000514	AMP binding site [chemical binding]; other site
243161000515	active site
243161000516	CoA binding site [chemical binding]; other site
243161000517	8-amino-7-oxononanoate synthase; Provisional; Region: PRK05937
243161000518	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
243161000519	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243161000520	catalytic residue [active]
243161000521	primosome assembly protein PriA; Validated; Region: PRK05580
243161000522	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243161000523	ATP binding site [chemical binding]; other site
243161000524	putative Mg++ binding site [ion binding]; other site
243161000525	helicase superfamily c-terminal domain; Region: HELICc; smart00490
243161000526	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
243161000527	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
243161000528	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
243161000529	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
243161000530	dimer interface [polypeptide binding]; other site
243161000531	putative anticodon binding site; other site
243161000532	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
243161000533	motif 1; other site
243161000534	dimer interface [polypeptide binding]; other site
243161000535	active site
243161000536	motif 2; other site
243161000537	motif 3; other site
243161000538	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
243161000539	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
243161000540	active site
243161000541	HIGH motif; other site
243161000542	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
243161000543	KMSKS motif; other site
243161000544	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
243161000545	tRNA binding surface [nucleotide binding]; other site
243161000546	anticodon binding site; other site
243161000547	Thioredoxin-like; Region: Thioredoxin_7; pfam13899
243161000548	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
243161000549	ribonuclease P; Reviewed; Region: rnpA; PRK00730
243161000550	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
243161000551	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
243161000552	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
243161000553	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
243161000554	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
243161000555	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
243161000556	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
243161000557	GIY-YIG motif/motif A; other site
243161000558	active site
243161000559	catalytic site [active]
243161000560	putative DNA binding site [nucleotide binding]; other site
243161000561	metal binding site [ion binding]; metal-binding site
243161000562	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
243161000563	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
243161000564	MutS domain I; Region: MutS_I; pfam01624
243161000565	MutS domain II; Region: MutS_II; pfam05188
243161000566	MutS domain III; Region: MutS_III; pfam05192
243161000567	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
243161000568	Walker A/P-loop; other site
243161000569	ATP binding site [chemical binding]; other site
243161000570	Q-loop/lid; other site
243161000571	ABC transporter signature motif; other site
243161000572	Walker B; other site
243161000573	D-loop; other site
243161000574	H-loop/switch region; other site
243161000575	DNA primase; Validated; Region: dnaG; PRK05667
243161000576	CHC2 zinc finger; Region: zf-CHC2; pfam01807
243161000577	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
243161000578	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
243161000579	active site
243161000580	metal binding site [ion binding]; metal-binding site
243161000581	interdomain interaction site; other site
243161000582	glycyl-tRNA synthetase; Provisional; Region: PRK14908
243161000583	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
243161000584	dimer interface [polypeptide binding]; other site
243161000585	motif 1; other site
243161000586	active site
243161000587	motif 2; other site
243161000588	motif 3; other site
243161000589	DALR anticodon binding domain; Region: DALR_1; pfam05746
243161000590	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
243161000591	glycogen synthase; Provisional; Region: glgA; PRK00654
243161000592	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
243161000593	ADP-binding pocket [chemical binding]; other site
243161000594	homodimer interface [polypeptide binding]; other site
243161000595	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
243161000596	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
243161000597	5S rRNA interface [nucleotide binding]; other site
243161000598	CTC domain interface [polypeptide binding]; other site
243161000599	L16 interface [polypeptide binding]; other site
243161000600	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
243161000601	putative active site [active]
243161000602	catalytic residue [active]
243161000603	Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360
243161000604	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
243161000605	Ribosomal protein L9 [Translation, ribosomal structure and biogenesis]; Region: RplI; COG0359
243161000606	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
243161000607	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
243161000608	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK00650
243161000609	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
243161000610	Protein of unknown function (DUF1504); Region: DUF1504; pfam07399
243161000611	Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025
243161000612	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
243161000613	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
243161000614	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
243161000615	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
243161000616	putative acyl-acceptor binding pocket; other site
243161000617	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
243161000618	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
243161000619	homodimer interface [polypeptide binding]; other site
243161000620	oligonucleotide binding site [chemical binding]; other site
243161000621	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
243161000622	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
243161000623	putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13846
243161000624	Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548
243161000625	Autotransporter beta-domain; Region: Autotransporter; pfam03797
243161000626	YtxH-like protein; Region: YtxH; pfam12732
243161000627	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314
243161000628	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
243161000629	active site
243161000630	substrate binding site [chemical binding]; other site
243161000631	metal binding site [ion binding]; metal-binding site
243161000632	glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135
243161000633	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
243161000634	glutaminase active site [active]
243161000635	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
243161000636	dimer interface [polypeptide binding]; other site
243161000637	active site
243161000638	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
243161000639	dimer interface [polypeptide binding]; other site
243161000640	active site
243161000641	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222
243161000642	aromatic amino acid transport protein; Region: araaP; TIGR00837
243161000643	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
243161000644	aromatic amino acid transport protein; Region: araaP; TIGR00837
243161000645	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
243161000646	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
243161000647	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
243161000648	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
243161000649	succinyl-CoA synthetase, beta subunit; Region: sucCoAbeta; TIGR01016
243161000650	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
243161000651	CoA-ligase; Region: Ligase_CoA; pfam00549
243161000652	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
243161000653	CoA binding domain; Region: CoA_binding; smart00881
243161000654	CoA-ligase; Region: Ligase_CoA; pfam00549
243161000655	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
243161000656	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
243161000657	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
243161000658	protein binding site [polypeptide binding]; other site
243161000659	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
243161000660	protein binding site [polypeptide binding]; other site
243161000661	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
243161000662	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
243161000663	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
243161000664	Peptidase M16C associated; Region: M16C_assoc; pfam08367
243161000665	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
243161000666	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
243161000667	RmuC family; Region: RmuC; pfam02646
243161000668	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
243161000669	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
243161000670	ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365
243161000671	ATP cone domain; Region: ATP-cone; pfam03477
243161000672	ATP cone domain; Region: ATP-cone; pfam03477
243161000673	Class I ribonucleotide reductase; Region: RNR_I; cd01679
243161000674	active site
243161000675	dimer interface [polypeptide binding]; other site
243161000676	catalytic residues [active]
243161000677	effector binding site; other site
243161000678	R2 peptide binding site; other site
243161000679	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
243161000680	dimer interface [polypeptide binding]; other site
243161000681	putative radical transfer pathway; other site
243161000682	diiron center [ion binding]; other site
243161000683	tyrosyl radical; other site
243161000684	Putative methyltransferase; Region: Methyltransf_4; pfam02390
243161000685	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
243161000686	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
243161000687	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
243161000688	FAD binding domain; Region: FAD_binding_4; pfam01565
243161000689	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
243161000690	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
243161000691	putative RNA binding site [nucleotide binding]; other site
243161000692	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
243161000693	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
243161000694	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
243161000695	Ribosomal protein L35 [Translation, ribosomal structure and biogenesis]; Region: RpmI; COG0291
243161000696	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
243161000697	23S rRNA binding site [nucleotide binding]; other site
243161000698	L21 binding site [polypeptide binding]; other site
243161000699	L13 binding site [polypeptide binding]; other site
243161000700	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
243161000701	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
243161000702	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
243161000703	dimer interface [polypeptide binding]; other site
243161000704	motif 1; other site
243161000705	active site
243161000706	motif 2; other site
243161000707	motif 3; other site
243161000708	Predicted permeases [General function prediction only]; Region: COG0795
243161000709	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
243161000710	Predicted permeases [General function prediction only]; Region: COG0795
243161000711	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
243161000712	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
243161000713	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
243161000714	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
243161000715	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243161000716	Walker A motif; other site
243161000717	ATP binding site [chemical binding]; other site
243161000718	Walker B motif; other site
243161000719	arginine finger; other site
243161000720	Peptidase family M41; Region: Peptidase_M41; pfam01434
243161000721	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
243161000722	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
243161000723	RNase E interface [polypeptide binding]; other site
243161000724	trimer interface [polypeptide binding]; other site
243161000725	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
243161000726	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
243161000727	RNase E interface [polypeptide binding]; other site
243161000728	trimer interface [polypeptide binding]; other site
243161000729	active site
243161000730	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
243161000731	putative nucleic acid binding region [nucleotide binding]; other site
243161000732	G-X-X-G motif; other site
243161000733	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
243161000734	RNA binding site [nucleotide binding]; other site
243161000735	domain interface; other site
243161000736	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
243161000737	16S/18S rRNA binding site [nucleotide binding]; other site
243161000738	S13e-L30e interaction site [polypeptide binding]; other site
243161000739	25S rRNA binding site [nucleotide binding]; other site
243161000740	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
243161000741	nucleoside/Zn binding site; other site
243161000742	dimer interface [polypeptide binding]; other site
243161000743	catalytic motif [active]
243161000744	Protein of unknown function (DUF720); Region: DUF720; pfam05302
243161000745	Protein of unknown function (DUF720); Region: DUF720; pfam05302
243161000746	Protein of unknown function (DUF720); Region: DUF720; pfam05302
243161000747	methionine aminopeptidase; Provisional; Region: PRK12318
243161000748	SEC-C motif; Region: SEC-C; pfam02810
243161000749	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
243161000750	active site
243161000751	MarC family integral membrane protein; Region: MarC; pfam01914
243161000752	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
243161000753	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
243161000754	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243161000755	dimer interface [polypeptide binding]; other site
243161000756	conserved gate region; other site
243161000757	putative PBP binding loops; other site
243161000758	ABC-ATPase subunit interface; other site
243161000759	NMT1/THI5 like; Region: NMT1; pfam09084
243161000760	fumarate hydratase, class II; Region: fumC_II; TIGR00979
243161000761	Class II fumarases; Region: Fumarase_classII; cd01362
243161000762	active site
243161000763	tetramer interface [polypeptide binding]; other site
243161000764	high affinity sulphate transporter 1; Region: sulP; TIGR00815
243161000765	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
243161000766	Sulfate transporter family; Region: Sulfate_transp; pfam00916
243161000767	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
243161000768	Na+/H+ antiporter, NhaD family; Region: NhaD; TIGR00775
243161000769	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
243161000770	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
243161000771	Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563
243161000772	active site triad [active]
243161000773	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
243161000774	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
243161000775	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
243161000776	type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552
243161000777	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243161000778	binding surface
243161000779	TPR motif; other site
243161000780	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
243161000781	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
243161000782	active site
243161000783	DNA binding site [nucleotide binding]
243161000784	Int/Topo IB signature motif; other site
243161000785	glycogen branching enzyme; Provisional; Region: PRK05402
243161000786	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
243161000787	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
243161000788	active site
243161000789	catalytic site [active]
243161000790	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
243161000791	Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784
243161000792	Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784
243161000793	Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548
243161000794	Autotransporter beta-domain; Region: Autotransporter; pfam03797
243161000795	Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548
243161000796	Autotransporter beta-domain; Region: Autotransporter; pfam03797
243161000797	Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548
243161000798	Autotransporter beta-domain; Region: Autotransporter; pfam03797
243161000799	Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376
243161000800	Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548
243161000801	Autotransporter beta-domain; Region: Autotransporter; pfam03797
243161000802	Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376
243161000803	Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548
243161000804	Autotransporter beta-domain; Region: Autotransporter; pfam03797
243161000805	Uncharacterized conserved protein [Function unknown]; Region: COG2155
243161000806	Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721
243161000807	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
243161000808	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
243161000809	Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064
243161000810	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
243161000811	GatB domain; Region: GatB_Yqey; pfam02637
243161000812	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
243161000813	ribonuclease HIII; Region: rnhC; TIGR00716
243161000814	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
243161000815	RNA/DNA hybrid binding site [nucleotide binding]; other site
243161000816	active site
243161000817	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
243161000818	Helix-turn-helix domain; Region: HTH_25; pfam13413
243161000819	lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK05906
243161000820	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
243161000821	putative acyl-acceptor binding pocket; other site
243161000822	Uncharacterized conserved protein [Function unknown]; Region: COG1624
243161000823	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
243161000824	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
243161000825	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
243161000826	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
243161000827	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
243161000828	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
243161000829	putative active site [active]
243161000830	PhoH-like protein; Region: PhoH; pfam02562
243161000831	Bacterial SH3 domain homologues; Region: SH3b; smart00287
243161000832	Bacterial SH3 domain homologues; Region: SH3b; smart00287
243161000833	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
243161000834	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
243161000835	HIGH motif; other site
243161000836	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
243161000837	active site
243161000838	KMSKS motif; other site
243161000839	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
243161000840	tRNA binding surface [nucleotide binding]; other site
243161000841	anticodon binding site; other site
243161000842	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
243161000843	Catalytic site [active]
243161000844	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
243161000845	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
243161000846	peptide chain release factor 1; Validated; Region: prfA; PRK00591
243161000847	PCRF domain; Region: PCRF; pfam03462
243161000848	RF-1 domain; Region: RF-1; pfam00472
243161000849	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
243161000850	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243161000851	S-adenosylmethionine binding site [chemical binding]; other site
243161000852	signal recognition particle protein; Region: ffh; TIGR00959
243161000853	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
243161000854	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
243161000855	P loop; other site
243161000856	GTP binding site [chemical binding]; other site
243161000857	Signal peptide binding domain; Region: SRP_SPB; pfam02978
243161000858	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14522
243161000859	tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Reviewed; Region: trmD; PRK01037
243161000860	tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmD; COG0336
243161000861	active site
243161000862	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
243161000863	ribosomal protein L19, bacterial type; Region: rplS_bact; TIGR01024
243161000864	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
243161000865	RNA/DNA hybrid binding site [nucleotide binding]; other site
243161000866	active site
243161000867	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
243161000868	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
243161000869	catalytic site [active]
243161000870	G-X2-G-X-G-K; other site
243161000871	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
243161000872	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
243161000873	active site
243161000874	HIGH motif; other site
243161000875	KMSKS motif; other site
243161000876	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
243161000877	tRNA binding surface [nucleotide binding]; other site
243161000878	anticodon binding site; other site
243161000879	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
243161000880	AAA domain; Region: AAA_30; pfam13604
243161000881	Family description; Region: UvrD_C_2; pfam13538
243161000882	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
243161000883	EamA-like transporter family; Region: EamA; pfam00892
243161000884	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144
243161000885	conserved cys residue [active]
243161000886	Transcriptional regulator Crl; Region: Crl; cl11653
243161000887	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
243161000888	trimer interface [polypeptide binding]; other site
243161000889	active site
243161000890	Holliday junction resolvasome, helicase subunit [DNA replication, recombination, and repair]; Region: RuvB; COG2255
243161000891	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243161000892	Walker A motif; other site
243161000893	ATP binding site [chemical binding]; other site
243161000894	Walker B motif; other site
243161000895	arginine finger; other site
243161000896	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
243161000897	Stage II sporulation protein; Region: SpoIID; pfam08486
243161000898	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
243161000899	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
243161000900	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
243161000901	active site
243161000902	catalytic site [active]
243161000903	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
243161000904	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
243161000905	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
243161000906	dimer interface [polypeptide binding]; other site
243161000907	ssDNA binding site [nucleotide binding]; other site
243161000908	tetramer (dimer of dimers) interface [polypeptide binding]; other site
243161000909	multifunctional aminopeptidase A; Provisional; Region: PRK00913
243161000910	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
243161000911	interface (dimer of trimers) [polypeptide binding]; other site
243161000912	Substrate-binding/catalytic site; other site
243161000913	Zn-binding sites [ion binding]; other site
243161000914	hypothetical protein; Provisional; Region: PRK05907
243161000915	Predicted methyltransferases [General function prediction only]; Region: COG0313
243161000916	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
243161000917	putative SAM binding site [chemical binding]; other site
243161000918	homodimer interface [polypeptide binding]; other site
243161000919	coproporphyrinogen III oxidase; Provisional; Region: PRK06294
243161000920	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243161000921	FeS/SAM binding site; other site
243161000922	2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567
243161000923	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
243161000924	TPP-binding site [chemical binding]; other site
243161000925	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
243161000926	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
243161000927	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
243161000928	E3 interaction surface; other site
243161000929	lipoyl attachment site [posttranslational modification]; other site
243161000930	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
243161000931	uncharacterized protein, YfiH family; Region: TIGR00726
243161000932	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
243161000933	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
243161000934	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048
243161000935	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749
243161000936	ADP-ribose binding site [chemical binding]; other site
243161000937	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
243161000938	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
243161000939	catalytic loop [active]
243161000940	iron binding site [ion binding]; other site
243161000941	type III secretion system protein; Validated; Region: PRK05910
243161000942	FHIPEP family; Region: FHIPEP; pfam00771
243161000943	RNA polymerase sigma factor sigma-28; Reviewed; Region: PRK05911
243161000944	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
243161000945	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
243161000946	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
243161000947	DNA binding residues [nucleotide binding]
243161000948	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
243161000949	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
243161000950	active site
243161000951	HIGH motif; other site
243161000952	dimer interface [polypeptide binding]; other site
243161000953	KMSKS motif; other site
243161000954	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
243161000955	RNA binding surface [nucleotide binding]; other site
243161000956	6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873
243161000957	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
243161000958	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
243161000959	GTP-binding protein LepA; Provisional; Region: PRK05433
243161000960	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
243161000961	G1 box; other site
243161000962	putative GEF interaction site [polypeptide binding]; other site
243161000963	GTP/Mg2+ binding site [chemical binding]; other site
243161000964	Switch I region; other site
243161000965	G2 box; other site
243161000966	G3 box; other site
243161000967	Switch II region; other site
243161000968	G4 box; other site
243161000969	G5 box; other site
243161000970	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
243161000971	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
243161000972	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
243161000973	ADP/ATP carrier protein family; Region: AAA; TIGR00769
243161000974	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
243161000975	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
243161000976	intersubunit interface [polypeptide binding]; other site
243161000977	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
243161000978	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
243161000979	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
243161000980	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
243161000981	ABC-ATPase subunit  interface; other site
243161000982	dimer interface [polypeptide binding]; other site
243161000983	putative PBP binding regions; other site
243161000984	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
243161000985	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
243161000986	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
243161000987	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
243161000988	ABC-ATPase subunit  interface; other site
243161000989	dimer interface [polypeptide binding]; other site
243161000990	putative PBP binding regions; other site
243161000991	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
243161000992	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
243161000993	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
243161000994	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
243161000995	RIP metalloprotease RseP; Region: TIGR00054
243161000996	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
243161000997	active site
243161000998	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
243161000999	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
243161001000	putative substrate binding region [chemical binding]; other site
243161001001	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
243161001002	Putative serine esterase (DUF676); Region: DUF676; pfam05057
243161001003	recF protein; Region: recf; TIGR00611
243161001004	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243161001005	Walker A/P-loop; other site
243161001006	ATP binding site [chemical binding]; other site
243161001007	Q-loop/lid; other site
243161001008	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243161001009	ABC transporter signature motif; other site
243161001010	Walker B; other site
243161001011	D-loop; other site
243161001012	H-loop/switch region; other site
243161001013	DNA polymerase III subunit beta; Validated; Region: PRK05643
243161001014	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
243161001015	putative DNA binding surface [nucleotide binding]; other site
243161001016	dimer interface [polypeptide binding]; other site
243161001017	beta-clamp/clamp loader binding surface; other site
243161001018	beta-clamp/translesion DNA polymerase binding surface; other site
243161001019	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
243161001020	SmpB-tmRNA interface; other site
243161001021	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
243161001022	ApbE family; Region: ApbE; pfam02424
243161001023	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14181
243161001024	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
243161001025	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
243161001026	homodimer interface [polypeptide binding]; other site
243161001027	NADP binding site [chemical binding]; other site
243161001028	substrate binding site [chemical binding]; other site
243161001029	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
243161001030	PLD-like domain; Region: PLDc_2; pfam13091
243161001031	putative active site [active]
243161001032	catalytic site [active]
243161001033	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
243161001034	PLD-like domain; Region: PLDc_2; pfam13091
243161001035	putative active site [active]
243161001036	catalytic site [active]
243161001037	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
243161001038	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
243161001039	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
243161001040	4-alpha-glucanotransferase; Region: Glyco_hydro_77; pfam02446
243161001041	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
243161001042	HrpJ-like domain; Region: HrpJ; cl15454
243161001043	Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789
243161001044	FHIPEP family; Region: FHIPEP; pfam00771
243161001045	type III secretion system protein; Validated; Region: PRK06298
243161001046	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
243161001047	GTP-binding protein YchF; Reviewed; Region: PRK09601
243161001048	YchF GTPase; Region: YchF; cd01900
243161001049	G1 box; other site
243161001050	GTP/Mg2+ binding site [chemical binding]; other site
243161001051	Switch I region; other site
243161001052	G2 box; other site
243161001053	Switch II region; other site
243161001054	G3 box; other site
243161001055	G4 box; other site
243161001056	G5 box; other site
243161001057	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
243161001058	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
243161001059	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
243161001060	active site
243161001061	Riboflavin kinase; Region: Flavokinase; pfam01687
243161001062	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
243161001063	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
243161001064	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
243161001065	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
243161001066	G1 box; other site
243161001067	putative GEF interaction site [polypeptide binding]; other site
243161001068	GTP/Mg2+ binding site [chemical binding]; other site
243161001069	Switch I region; other site
243161001070	G2 box; other site
243161001071	G3 box; other site
243161001072	Switch II region; other site
243161001073	G4 box; other site
243161001074	G5 box; other site
243161001075	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
243161001076	Translation-initiation factor 2; Region: IF-2; pfam11987
243161001077	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
243161001078	transcription termination factor NusA; Region: NusA; TIGR01953
243161001079	NusA N-terminal domain; Region: NusA_N; pfam08529
243161001080	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
243161001081	RNA binding site [nucleotide binding]; other site
243161001082	homodimer interface [polypeptide binding]; other site
243161001083	NusA-like KH domain; Region: KH_5; pfam13184
243161001084	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
243161001085	G-X-X-G motif; other site
243161001086	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
243161001087	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
243161001088	RNA binding site [nucleotide binding]; other site
243161001089	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
243161001090	RNA binding site [nucleotide binding]; other site
243161001091	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
243161001092	RNA binding site [nucleotide binding]; other site
243161001093	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
243161001094	RNA binding site [nucleotide binding]; other site
243161001095	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
243161001096	RNA binding site [nucleotide binding]; other site
243161001097	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
243161001098	RNA binding site [nucleotide binding]; other site
243161001099	domain interface; other site
243161001100	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
243161001101	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
243161001102	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
243161001103	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
243161001104	Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190
243161001105	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
243161001106	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
243161001107	active site
243161001108	motif I; other site
243161001109	motif II; other site
243161001110	enoyl-[acyl-carrier-protein] reductase; Region: PLN02730
243161001111	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
243161001112	NAD binding site [chemical binding]; other site
243161001113	homotetramer interface [polypeptide binding]; other site
243161001114	homodimer interface [polypeptide binding]; other site
243161001115	substrate binding site [chemical binding]; other site
243161001116	active site
243161001117	A/G-specific adenine glycosylase; Region: mutY; TIGR01084
243161001118	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
243161001119	minor groove reading motif; other site
243161001120	helix-hairpin-helix signature motif; other site
243161001121	substrate binding pocket [chemical binding]; other site
243161001122	active site
243161001123	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
243161001124	DNA binding and oxoG recognition site [nucleotide binding]
243161001125	Uncharacterized conserved protein [Function unknown]; Region: COG0327
243161001126	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
243161001127	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
243161001128	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
243161001129	ring oligomerisation interface [polypeptide binding]; other site
243161001130	ATP/Mg binding site [chemical binding]; other site
243161001131	stacking interactions; other site
243161001132	hinge regions; other site
243161001133	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
243161001134	oligomerisation interface [polypeptide binding]; other site
243161001135	mobile loop; other site
243161001136	roof hairpin; other site
243161001137	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
243161001138	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
243161001139	active site
243161001140	Zn binding site [ion binding]; other site
243161001141	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
243161001142	Clp amino terminal domain; Region: Clp_N; pfam02861
243161001143	Clp amino terminal domain; Region: Clp_N; pfam02861
243161001144	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243161001145	Walker A motif; other site
243161001146	ATP binding site [chemical binding]; other site
243161001147	Walker B motif; other site
243161001148	arginine finger; other site
243161001149	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243161001150	Walker A motif; other site
243161001151	ATP binding site [chemical binding]; other site
243161001152	Walker B motif; other site
243161001153	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
243161001154	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
243161001155	IncA protein; Region: IncA; pfam04156
243161001156	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
243161001157	Protein of unknown function (DUF1515); Region: DUF1515; pfam07439
243161001158	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
243161001159	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
243161001160	substrate binding site [chemical binding]; other site
243161001161	hexamer interface [polypeptide binding]; other site
243161001162	metal binding site [ion binding]; metal-binding site
243161001163	elongation factor P; Provisional; Region: PRK12426
243161001164	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
243161001165	RNA binding site [nucleotide binding]; other site
243161001166	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
243161001167	RNA binding site [nucleotide binding]; other site
243161001168	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
243161001169	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
243161001170	carboxyltransferase (CT) interaction site; other site
243161001171	biotinylation site [posttranslational modification]; other site
243161001172	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
243161001173	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
243161001174	ATP-grasp domain; Region: ATP-grasp_4; cl17255
243161001175	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
243161001176	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
243161001177	23S rRNA interface [nucleotide binding]; other site
243161001178	L3 interface [polypeptide binding]; other site
243161001179	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
243161001180	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
243161001181	NlpC/P60 family; Region: NLPC_P60; cl17555
243161001182	adenylate kinase; Region: adk; TIGR01351
243161001183	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
243161001184	AMP-binding site [chemical binding]; other site
243161001185	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
243161001186	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
243161001187	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243161001188	dimer interface [polypeptide binding]; other site
243161001189	conserved gate region; other site
243161001190	putative PBP binding loops; other site
243161001191	ABC-ATPase subunit interface; other site
243161001192	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
243161001193	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243161001194	Walker A/P-loop; other site
243161001195	ATP binding site [chemical binding]; other site
243161001196	Q-loop/lid; other site
243161001197	ABC transporter signature motif; other site
243161001198	Walker B; other site
243161001199	D-loop; other site
243161001200	H-loop/switch region; other site
243161001201	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
243161001202	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243161001203	Methyltransferase domain; Region: Methyltransf_31; pfam13847
243161001204	S-adenosylmethionine binding site [chemical binding]; other site
243161001205	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
243161001206	Serine hydrolase (FSH1); Region: FSH1; pfam03959
243161001207	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
243161001208	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
243161001209	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
243161001210	active site
243161001211	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
243161001212	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
243161001213	conserved hypothetical integral membrane protein; Region: TIGR00697
243161001214	Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318
243161001215	SEC-C motif; Region: SEC-C; pfam02810
243161001216	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
243161001217	Catalytic domain of Protein Kinases; Region: PKc; cd00180
243161001218	active site
243161001219	ATP binding site [chemical binding]; other site
243161001220	substrate binding site [chemical binding]; other site
243161001221	activation loop (A-loop); other site
243161001222	Uncharacterized conserved protein [Function unknown]; Region: COG1262
243161001223	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
243161001224	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
243161001225	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
243161001226	nucleotide binding pocket [chemical binding]; other site
243161001227	K-X-D-G motif; other site
243161001228	catalytic site [active]
243161001229	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
243161001230	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
243161001231	Helix-hairpin-helix motif; Region: HHH; pfam00633
243161001232	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
243161001233	Dimer interface [polypeptide binding]; other site
243161001234	BRCT sequence motif; other site
243161001235	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
243161001236	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
243161001237	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
243161001238	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
243161001239	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
243161001240	FtsX-like permease family; Region: FtsX; pfam02687
243161001241	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
243161001242	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
243161001243	Walker A/P-loop; other site
243161001244	ATP binding site [chemical binding]; other site
243161001245	Q-loop/lid; other site
243161001246	ABC transporter signature motif; other site
243161001247	Walker B; other site
243161001248	D-loop; other site
243161001249	H-loop/switch region; other site
243161001250	MAC/Perforin domain; Region: MACPF; cl02616
243161001251	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
243161001252	PLD-like domain; Region: PLDc_2; pfam13091
243161001253	putative active site [active]
243161001254	catalytic site [active]
243161001255	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
243161001256	PLD-like domain; Region: PLDc_2; pfam13091
243161001257	putative active site [active]
243161001258	catalytic site [active]
243161001259	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
243161001260	PLD-like domain; Region: PLDc_2; pfam13091
243161001261	putative active site [active]
243161001262	catalytic site [active]
243161001263	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
243161001264	PLD-like domain; Region: PLDc_2; pfam13091
243161001265	putative active site [active]
243161001266	catalytic site [active]
243161001267	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
243161001268	PLD-like domain; Region: PLDc_2; pfam13091
243161001269	putative active site [active]
243161001270	catalytic site [active]
243161001271	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
243161001272	PLD-like domain; Region: PLDc_2; pfam13091
243161001273	putative active site [active]
243161001274	catalytic site [active]
243161001275	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
243161001276	PLD-like domain; Region: PLDc_2; pfam13091
243161001277	putative active site [active]
243161001278	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
243161001279	PLD-like domain; Region: PLDc_2; pfam13091
243161001280	putative active site [active]
243161001281	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
243161001282	putative active site [active]
243161001283	catalytic site [active]
243161001284	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
243161001285	PLD-like domain; Region: PLDc_2; pfam13091
243161001286	putative active site [active]
243161001287	catalytic site [active]
243161001288	TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918
243161001289	TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919
243161001290	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
243161001291	Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145
243161001292	TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920
243161001293	Protein of unknown function (DUF3491); Region: DUF3491; pfam11996
243161001294	TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918
243161001295	TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919
243161001296	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
243161001297	cysteine protease domain, YopT-type; Region: yopT_cys_prot; TIGR01586
243161001298	Protein of unknown function (DUF3491); Region: DUF3491; pfam11996
243161001299	TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918
243161001300	TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919
243161001301	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
243161001302	cysteine protease domain, YopT-type; Region: yopT_cys_prot; TIGR01586
243161001303	TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920
243161001304	Protein of unknown function (DUF3491); Region: DUF3491; pfam11996
243161001305	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
243161001306	PLD-like domain; Region: PLDc_2; pfam13091
243161001307	putative active site [active]
243161001308	catalytic site [active]
243161001309	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
243161001310	PLD-like domain; Region: PLDc_2; pfam13091
243161001311	putative active site [active]
243161001312	catalytic site [active]
243161001313	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
243161001314	Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze  the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443
243161001315	active site
243161001316	GMP synthase; Reviewed; Region: guaA; PRK00074
243161001317	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
243161001318	AMP/PPi binding site [chemical binding]; other site
243161001319	candidate oxyanion hole; other site
243161001320	catalytic triad [active]
243161001321	potential glutamine specificity residues [chemical binding]; other site
243161001322	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
243161001323	ATP Binding subdomain [chemical binding]; other site
243161001324	Ligand Binding sites [chemical binding]; other site
243161001325	Dimerization subdomain; other site
243161001326	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843
243161001327	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
243161001328	active site
243161001329	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
243161001330	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
243161001331	peptide binding site [polypeptide binding]; other site
243161001332	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
243161001333	PLD-like domain; Region: PLDc_2; pfam13091
243161001334	putative active site [active]
243161001335	catalytic site [active]
243161001336	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
243161001337	PLD-like domain; Region: PLDc_2; pfam13091
243161001338	putative active site [active]
243161001339	catalytic site [active]
243161001340	putative disulfide oxidoreductase; Provisional; Region: PRK00611
243161001341	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
243161001342	Thioredoxin; Region: Thioredoxin_4; cl17273
243161001343	Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cd10546
243161001344	putative active site [active]
243161001345	redox center [active]
243161001346	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
243161001347	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243161001348	Walker A/P-loop; other site
243161001349	ATP binding site [chemical binding]; other site
243161001350	Q-loop/lid; other site
243161001351	ABC transporter signature motif; other site
243161001352	Walker B; other site
243161001353	D-loop; other site
243161001354	H-loop/switch region; other site
243161001355	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
243161001356	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
243161001357	Ligand binding site; other site
243161001358	oligomer interface; other site
243161001359	CTP synthetase; Validated; Region: pyrG; PRK05380
243161001360	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
243161001361	Catalytic site [active]
243161001362	active site
243161001363	UTP binding site [chemical binding]; other site
243161001364	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
243161001365	active site
243161001366	putative oxyanion hole; other site
243161001367	catalytic triad [active]
243161001368	Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816
243161001369	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
243161001370	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
243161001371	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
243161001372	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
243161001373	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
243161001374	putative active site [active]
243161001375	DNA polymerase III subunit delta'; Validated; Region: PRK05917
243161001376	DNA polymerase III subunit delta'; Validated; Region: PRK08485
243161001377	thymidylate kinase; Validated; Region: tmk; PRK00698
243161001378	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
243161001379	TMP-binding site; other site
243161001380	ATP-binding site [chemical binding]; other site
243161001381	DNA gyrase, A subunit; Region: gyrA; TIGR01063
243161001382	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
243161001383	CAP-like domain; other site
243161001384	active site
243161001385	primary dimer interface [polypeptide binding]; other site
243161001386	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243161001387	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243161001388	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243161001389	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243161001390	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243161001391	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243161001392	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
243161001393	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243161001394	ATP binding site [chemical binding]; other site
243161001395	Mg2+ binding site [ion binding]; other site
243161001396	G-X-G motif; other site
243161001397	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
243161001398	anchoring element; other site
243161001399	dimer interface [polypeptide binding]; other site
243161001400	ATP binding site [chemical binding]; other site
243161001401	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
243161001402	active site
243161001403	putative metal-binding site [ion binding]; other site
243161001404	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
243161001405	Protein of unknown function (DUF721); Region: DUF721; pfam05258
243161001406	queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008
243161001407	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
243161001408	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
243161001409	MgtE intracellular N domain; Region: MgtE_N; pfam03448
243161001410	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
243161001411	Divalent cation transporter; Region: MgtE; pfam01769
243161001412	UGMP family protein; Validated; Region: PRK09604
243161001413	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
243161001414	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
243161001415	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
243161001416	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
243161001417	peptide binding site [polypeptide binding]; other site
243161001418	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
243161001419	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243161001420	dimer interface [polypeptide binding]; other site
243161001421	conserved gate region; other site
243161001422	putative PBP binding loops; other site
243161001423	ABC-ATPase subunit interface; other site
243161001424	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
243161001425	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
243161001426	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243161001427	dimer interface [polypeptide binding]; other site
243161001428	conserved gate region; other site
243161001429	putative PBP binding loops; other site
243161001430	ABC-ATPase subunit interface; other site
243161001431	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
243161001432	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
243161001433	Walker A/P-loop; other site
243161001434	ATP binding site [chemical binding]; other site
243161001435	Q-loop/lid; other site
243161001436	ABC transporter signature motif; other site
243161001437	Walker B; other site
243161001438	D-loop; other site
243161001439	H-loop/switch region; other site
243161001440	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
243161001441	Protein of unknown function (DUF1186); Region: DUF1186; pfam06685
243161001442	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
243161001443	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
243161001444	transmembrane helices; other site
243161001445	diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085
243161001446	pyrophosphate-dependent phosphofructokinase; Region: PLN02251
243161001447	active site
243161001448	ADP/pyrophosphate binding site [chemical binding]; other site
243161001449	dimerization interface [polypeptide binding]; other site
243161001450	allosteric effector site; other site
243161001451	fructose-1,6-bisphosphate binding site; other site
243161001452	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
243161001453	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243161001454	diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085
243161001455	pyrophosphate-dependent phosphofructokinase; Region: PLN02251
243161001456	active site
243161001457	ADP/pyrophosphate binding site [chemical binding]; other site
243161001458	dimerization interface [polypeptide binding]; other site
243161001459	allosteric effector site; other site
243161001460	fructose-1,6-bisphosphate binding site; other site
243161001461	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
243161001462	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
243161001463	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
243161001464	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
243161001465	HIGH motif; other site
243161001466	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
243161001467	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
243161001468	active site
243161001469	KMSKS motif; other site
243161001470	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
243161001471	tRNA binding surface [nucleotide binding]; other site
243161001472	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00615
243161001473	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
243161001474	inhibitor-cofactor binding pocket; inhibition site
243161001475	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243161001476	catalytic residue [active]
243161001477	Putative transcriptional regulator [Transcription]; Region: COG1678
243161001478	Uncharacterized conserved protein [Function unknown]; Region: COG1259
243161001479	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
243161001480	tetramer (dimer of dimers) interface [polypeptide binding]; other site
243161001481	active site
243161001482	dimer interface [polypeptide binding]; other site
243161001483	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
243161001484	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
243161001485	putative active site; other site
243161001486	catalytic residue [active]
243161001487	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
243161001488	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
243161001489	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
243161001490	Ligand Binding Site [chemical binding]; other site
243161001491	Part of AAA domain; Region: AAA_19; pfam13245
243161001492	Family description; Region: UvrD_C_2; pfam13538
243161001493	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243161001494	DNA binding residues [nucleotide binding]
243161001495	dimerization interface [polypeptide binding]; other site
243161001496	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
243161001497	prenyltransferase; Reviewed; Region: ubiA; PRK12876
243161001498	UbiA prenyltransferase family; Region: UbiA; pfam01040
243161001499	aromatic acid decarboxylase; Validated; Region: PRK05920
243161001500	Flavoprotein; Region: Flavoprotein; pfam02441
243161001501	Uncharacterized conserved protein [Function unknown]; Region: COG1284
243161001502	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
243161001503	IncA protein; Region: IncA; pfam04156
243161001504	IncA protein; Region: IncA; pfam04156
243161001505	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
243161001506	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
243161001507	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
243161001508	Na2 binding site [ion binding]; other site
243161001509	putative substrate binding site 1 [chemical binding]; other site
243161001510	Na binding site 1 [ion binding]; other site
243161001511	putative substrate binding site 2 [chemical binding]; other site
243161001512	TLC ATP/ADP transporter; Region: TLC; cl03940
243161001513	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
243161001514	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
243161001515	ligand binding site [chemical binding]; other site
243161001516	flexible hinge region; other site
243161001517	acyl carrier protein; Provisional; Region: acpP; PRK00982
243161001518	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
243161001519	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
243161001520	NAD(P) binding site [chemical binding]; other site
243161001521	homotetramer interface [polypeptide binding]; other site
243161001522	homodimer interface [polypeptide binding]; other site
243161001523	active site
243161001524	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
243161001525	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
243161001526	3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747
243161001527	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
243161001528	dimer interface [polypeptide binding]; other site
243161001529	active site
243161001530	CoA binding pocket [chemical binding]; other site
243161001531	recombination protein RecR; Region: recR; TIGR00615
243161001532	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
243161001533	putative active site [active]
243161001534	putative metal-binding site [ion binding]; other site
243161001535	tetramer interface [polypeptide binding]; other site
243161001536	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
243161001537	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
243161001538	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
243161001539	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
243161001540	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
243161001541	Surface antigen; Region: Bac_surface_Ag; pfam01103
243161001542	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
243161001543	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853
243161001544	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
243161001545	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
243161001546	trimer interface [polypeptide binding]; other site
243161001547	active site
243161001548	UDP-GlcNAc binding site [chemical binding]; other site
243161001549	lipid binding site [chemical binding]; lipid-binding site
243161001550	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
243161001551	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
243161001552	tetramer interface [polypeptide binding]; other site
243161001553	TPP-binding site [chemical binding]; other site
243161001554	heterodimer interface [polypeptide binding]; other site
243161001555	phosphorylation loop region [posttranslational modification]
243161001556	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
243161001557	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
243161001558	alpha subunit interface [polypeptide binding]; other site
243161001559	TPP binding site [chemical binding]; other site
243161001560	heterodimer interface [polypeptide binding]; other site
243161001561	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
243161001562	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
243161001563	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
243161001564	E3 interaction surface; other site
243161001565	lipoyl attachment site [posttranslational modification]; other site
243161001566	e3 binding domain; Region: E3_binding; pfam02817
243161001567	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
243161001568	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
243161001569	homodimer interface [polypeptide binding]; other site
243161001570	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
243161001571	active site pocket [active]
243161001572	chromosomal replication initiation protein; Provisional; Region: PRK12422
243161001573	DnaA N-terminal domain; Region: DnaA_N; pfam11638
243161001574	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243161001575	Walker A motif; other site
243161001576	ATP binding site [chemical binding]; other site
243161001577	Walker B motif; other site
243161001578	arginine finger; other site
243161001579	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
243161001580	DnaA box-binding interface [nucleotide binding]; other site
243161001581	putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001
243161001582	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
243161001583	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
243161001584	CAAX protease self-immunity; Region: Abi; pfam02517
243161001585	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
243161001586	homodimer interface [polypeptide binding]; other site
243161001587	metal binding site [ion binding]; metal-binding site
243161001588	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
243161001589	Domain of unknown function DUF21; Region: DUF21; pfam01595
243161001590	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
243161001591	Transporter associated domain; Region: CorC_HlyC; smart01091
243161001592	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
243161001593	Domain of unknown function DUF21; Region: DUF21; pfam01595
243161001594	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
243161001595	Transporter associated domain; Region: CorC_HlyC; smart01091
243161001596	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
243161001597	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
243161001598	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243161001599	catalytic residue [active]
243161001600	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
243161001601	Protein phosphatase 2C; Region: PP2C; pfam00481
243161001602	active site
243161001603	Uncharacterized conserved protein [Function unknown]; Region: COG5465
243161001604	DNA polymerase III subunit epsilon; Validated; Region: PRK06309
243161001605	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
243161001606	active site
243161001607	catalytic site [active]
243161001608	substrate binding site [chemical binding]; other site
243161001609	Protein of unknown function (DUF3820); Region: DUF3820; cl01411
243161001610	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107
243161001611	nucleosidase; Provisional; Region: PRK05634
243161001612	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
243161001613	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
243161001614	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243161001615	Walker A/P-loop; other site
243161001616	ATP binding site [chemical binding]; other site
243161001617	Q-loop/lid; other site
243161001618	ABC transporter signature motif; other site
243161001619	Walker B; other site
243161001620	D-loop; other site
243161001621	H-loop/switch region; other site
243161001622	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
243161001623	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
243161001624	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
243161001625	IHF - DNA interface [nucleotide binding]; other site
243161001626	IHF dimer interface [polypeptide binding]; other site
243161001627	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
243161001628	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
243161001629	active site
243161001630	metal binding site [ion binding]; metal-binding site
243161001631	UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085
243161001632	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
243161001633	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
243161001634	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
243161001635	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
243161001636	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
243161001637	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
243161001638	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
243161001639	MraW methylase family; Region: Methyltransf_5; pfam01795
243161001640	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243161001641	TPR motif; other site
243161001642	binding surface
243161001643	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
243161001644	DnaA N-terminal domain; Region: DnaA_N; pfam11638
243161001645	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243161001646	Walker A motif; other site
243161001647	ATP binding site [chemical binding]; other site
243161001648	Walker B motif; other site
243161001649	arginine finger; other site
243161001650	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
243161001651	DnaA box-binding interface [nucleotide binding]; other site
243161001652	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
243161001653	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
243161001654	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024
243161001655	FMN-binding domain; Region: FMN_bind; cl01081
243161001656	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
243161001657	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
243161001658	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061
243161001659	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
243161001660	lipoyl attachment site [posttranslational modification]; other site
243161001661	Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076
243161001662	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
243161001663	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
243161001664	putative active site [active]
243161001665	catalytic site [active]
243161001666	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
243161001667	putative active site [active]
243161001668	catalytic site [active]
243161001669	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
243161001670	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
243161001671	Clp amino terminal domain; Region: Clp_N; pfam02861
243161001672	Clp amino terminal domain; Region: Clp_N; pfam02861
243161001673	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243161001674	Walker A motif; other site
243161001675	ATP binding site [chemical binding]; other site
243161001676	Walker B motif; other site
243161001677	arginine finger; other site
243161001678	UvrB/uvrC motif; Region: UVR; pfam02151
243161001679	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243161001680	Walker A motif; other site
243161001681	ATP binding site [chemical binding]; other site
243161001682	Walker B motif; other site
243161001683	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
243161001684	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
243161001685	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
243161001686	Ligand Binding Site [chemical binding]; other site
243161001687	Helix-turn-helix domain; Region: HTH_17; cl17695
243161001688	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
243161001689	active site
243161001690	phosphorylation site [posttranslational modification]
243161001691	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
243161001692	active site
243161001693	phosphorylation site [posttranslational modification]
243161001694	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
243161001695	trimer interface [polypeptide binding]; other site
243161001696	active site
243161001697	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
243161001698	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
243161001699	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
243161001700	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
243161001701	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
243161001702	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
243161001703	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
243161001704	active site
243161001705	substrate binding site [chemical binding]; other site
243161001706	metal binding site [ion binding]; metal-binding site
243161001707	ribonuclease III; Reviewed; Region: rnc; PRK00102
243161001708	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
243161001709	dimerization interface [polypeptide binding]; other site
243161001710	active site
243161001711	metal binding site [ion binding]; metal-binding site
243161001712	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
243161001713	dsRNA binding site [nucleotide binding]; other site
243161001714	DNA repair protein RadA; Provisional; Region: PRK11823
243161001715	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
243161001716	Walker A motif/ATP binding site; other site
243161001717	ATP binding site [chemical binding]; other site
243161001718	Walker B motif; other site
243161001719	porphobilinogen deaminase; Provisional; Region: PRK01066
243161001720	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
243161001721	domain interfaces; other site
243161001722	active site
243161001723	serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184
243161001724	Catalytic domain of Protein Kinases; Region: PKc; cd00180
243161001725	active site
243161001726	ATP binding site [chemical binding]; other site
243161001727	substrate binding site [chemical binding]; other site
243161001728	activation loop (A-loop); other site
243161001729	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
243161001730	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
243161001731	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
243161001732	HIGH motif; other site
243161001733	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
243161001734	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
243161001735	active site
243161001736	KMSKS motif; other site
243161001737	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
243161001738	tRNA binding surface [nucleotide binding]; other site
243161001739	anticodon binding site; other site
243161001740	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
243161001741	V-type ATP synthase subunit K; Provisional; Region: PRK09621
243161001742	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
243161001743	V-type ATP synthase subunit I; Validated; Region: PRK05771
243161001744	Protein of unknown function (DUF1319); Region: DUF1319; pfam07028
243161001745	V-type ATP synthase subunit D; Provisional; Region: PRK02195
243161001746	V-type ATP synthase subunit B; Provisional; Region: PRK02118
243161001747	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
243161001748	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
243161001749	Walker A motif homologous position; other site
243161001750	Walker B motif; other site
243161001751	V-type ATP synthase subunit A; Provisional; Region: PRK04192
243161001752	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
243161001753	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
243161001754	Walker A motif/ATP binding site; other site
243161001755	Walker B motif; other site
243161001756	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
243161001757	Protein of unknown function (DUF2764); Region: DUF2764; pfam10962
243161001758	V-type ATP synthase subunit E; Provisional; Region: PRK01005
243161001759	V-type ATP synthase subunit E; Provisional; Region: PRK01558
243161001760	transaldolase-like protein; Provisional; Region: PTZ00411
243161001761	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
243161001762	active site
243161001763	dimer interface [polypeptide binding]; other site
243161001764	catalytic residue [active]
243161001765	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
243161001766	DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386
243161001767	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
243161001768	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
243161001769	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
243161001770	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
243161001771	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
243161001772	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
243161001773	DNA binding site [nucleotide binding]
243161001774	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
243161001775	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563
243161001776	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
243161001777	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
243161001778	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
243161001779	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
243161001780	RPB12 interaction site [polypeptide binding]; other site
243161001781	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
243161001782	RPB3 interaction site [polypeptide binding]; other site
243161001783	RPB1 interaction site [polypeptide binding]; other site
243161001784	RPB11 interaction site [polypeptide binding]; other site
243161001785	RPB10 interaction site [polypeptide binding]; other site
243161001786	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
243161001787	core dimer interface [polypeptide binding]; other site
243161001788	peripheral dimer interface [polypeptide binding]; other site
243161001789	L10 interface [polypeptide binding]; other site
243161001790	L11 interface [polypeptide binding]; other site
243161001791	putative EF-Tu interaction site [polypeptide binding]; other site
243161001792	putative EF-G interaction site [polypeptide binding]; other site
243161001793	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
243161001794	23S rRNA interface [nucleotide binding]; other site
243161001795	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
243161001796	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
243161001797	mRNA/rRNA interface [nucleotide binding]; other site
243161001798	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
243161001799	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
243161001800	putative thiostrepton binding site; other site
243161001801	23S rRNA interface [nucleotide binding]; other site
243161001802	L7/L12 interface [polypeptide binding]; other site
243161001803	L25 interface [polypeptide binding]; other site
243161001804	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
243161001805	transcription termination/antitermination factor NusG; Region: nusG; TIGR00922
243161001806	putative homodimer interface [polypeptide binding]; other site
243161001807	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
243161001808	heterodimer interface [polypeptide binding]; other site
243161001809	homodimer interface [polypeptide binding]; other site
243161001810	Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690
243161001811	elongation factor Tu; Reviewed; Region: PRK12735
243161001812	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
243161001813	G1 box; other site
243161001814	GEF interaction site [polypeptide binding]; other site
243161001815	GTP/Mg2+ binding site [chemical binding]; other site
243161001816	Switch I region; other site
243161001817	G2 box; other site
243161001818	G3 box; other site
243161001819	Switch II region; other site
243161001820	G4 box; other site
243161001821	G5 box; other site
243161001822	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
243161001823	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
243161001824	Antibiotic Binding Site [chemical binding]; other site
243161001825	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
243161001826	rRNA binding site [nucleotide binding]; other site
243161001827	predicted 30S ribosome binding site; other site
243161001828	Fe-S metabolism associated domain; Region: SufE; pfam02657
243161001829	Protein of unknown function (DUF687); Region: DUF687; pfam05095
243161001830	Restriction endonuclease; Region: Mrr_cat_2; pfam13156
243161001831	DEAD-like helicases superfamily; Region: DEXDc; smart00487
243161001832	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243161001833	ATP binding site [chemical binding]; other site
243161001834	putative Mg++ binding site [ion binding]; other site
243161001835	nucleotide binding region [chemical binding]; other site
243161001836	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
243161001837	ATP-binding site [chemical binding]; other site
243161001838	Helicase associated domain; Region: HA; pfam03457
243161001839	Helicase associated domain; Region: HA; pfam03457
243161001840	Helicase associated domain; Region: HA; pfam03457
243161001841	Helicase associated domain; Region: HA; pfam03457
243161001842	Helicase associated domain; Region: HA; pfam03457
243161001843	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
243161001844	active site
243161001845	triosephosphate isomerase; Provisional; Region: PRK14565
243161001846	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
243161001847	substrate binding site [chemical binding]; other site
243161001848	dimer interface [polypeptide binding]; other site
243161001849	catalytic triad [active]
243161001850	Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570
243161001851	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
243161001852	generic binding surface II; other site
243161001853	generic binding surface I; other site
243161001854	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
243161001855	Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154
243161001856	1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292
243161001857	TPP-binding site [chemical binding]; other site
243161001858	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
243161001859	PYR/PP interface [polypeptide binding]; other site
243161001860	dimer interface [polypeptide binding]; other site
243161001861	TPP binding site [chemical binding]; other site
243161001862	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
243161001863	pyruvate kinase; Region: pyruv_kin; TIGR01064
243161001864	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
243161001865	domain interfaces; other site
243161001866	active site
243161001867	excinuclease ABC subunit A; Provisional; Region: PRK00635
243161001868	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
243161001869	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
243161001870	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
243161001871	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243161001872	Walker A/P-loop; other site
243161001873	ATP binding site [chemical binding]; other site
243161001874	Q-loop/lid; other site
243161001875	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243161001876	ABC transporter signature motif; other site
243161001877	Walker B; other site
243161001878	D-loop; other site
243161001879	H-loop/switch region; other site
243161001880	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243161001881	Walker A/P-loop; other site
243161001882	ATP binding site [chemical binding]; other site
243161001883	Q-loop/lid; other site
243161001884	ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238
243161001885	DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305
243161001886	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243161001887	Walker A motif; other site
243161001888	ATP binding site [chemical binding]; other site
243161001889	Walker B motif; other site
243161001890	arginine finger; other site
243161001891	hypothetical protein; Validated; Region: PRK00153
243161001892	phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417
243161001893	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
243161001894	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
243161001895	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
243161001896	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
243161001897	regulatory protein interface [polypeptide binding]; other site
243161001898	active site
243161001899	regulatory phosphorylation site [posttranslational modification]; other site
243161001900	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
243161001901	Competence protein; Region: Competence; pfam03772
243161001902	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
243161001903	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
243161001904	tetramer interface [polypeptide binding]; other site
243161001905	TPP-binding site [chemical binding]; other site
243161001906	heterodimer interface [polypeptide binding]; other site
243161001907	phosphorylation loop region [posttranslational modification]
243161001908	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
243161001909	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
243161001910	alpha subunit interface [polypeptide binding]; other site
243161001911	TPP binding site [chemical binding]; other site
243161001912	heterodimer interface [polypeptide binding]; other site
243161001913	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
243161001914	chaperone protein DnaJ; Provisional; Region: PRK14284
243161001915	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
243161001916	HSP70 interaction site [polypeptide binding]; other site
243161001917	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
243161001918	Zn binding sites [ion binding]; other site
243161001919	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
243161001920	dimer interface [polypeptide binding]; other site
243161001921	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
243161001922	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
243161001923	Glycoprotease family; Region: Peptidase_M22; pfam00814
243161001924	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
243161001925	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243161001926	Walker A motif; other site
243161001927	ATP binding site [chemical binding]; other site
243161001928	Walker B motif; other site
243161001929	arginine finger; other site
243161001930	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
243161001931	ribonuclease Z; Region: RNase_Z; TIGR02651
243161001932	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
243161001933	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
243161001934	active site
243161001935	Int/Topo IB signature motif; other site
243161001936	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
243161001937	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
243161001938	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
243161001939	ABC transporter; Region: ABC_tran_2; pfam12848
243161001940	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
243161001941	Maf-like protein; Region: Maf; pfam02545
243161001942	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
243161001943	active site
243161001944	dimer interface [polypeptide binding]; other site
243161001945	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
243161001946	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
243161001947	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
243161001948	active site
243161001949	catalytic residues [active]
243161001950	metal binding site [ion binding]; metal-binding site
243161001951	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
243161001952	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243161001953	S-adenosylmethionine binding site [chemical binding]; other site
243161001954	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
243161001955	Protein of unknown function, DUF255; Region: DUF255; pfam03190
243161001956	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
243161001957	dihydrodipicolinate synthase; Region: dapA; TIGR00674
243161001958	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
243161001959	inhibitor site; inhibition site
243161001960	active site
243161001961	dimer interface [polypeptide binding]; other site
243161001962	catalytic residue [active]
243161001963	aspartate kinase; Provisional; Region: PRK05925
243161001964	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
243161001965	nucleotide binding site [chemical binding]; other site
243161001966	substrate binding site [chemical binding]; other site
243161001967	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
243161001968	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
243161001969	dihydrodipicolinate reductase; Provisional; Region: PRK00048
243161001970	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
243161001971	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
243161001972	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
243161001973	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
243161001974	hinge; other site
243161001975	active site
243161001976	shikimate kinase; Provisional; Region: PRK00625
243161001977	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
243161001978	ADP binding site [chemical binding]; other site
243161001979	magnesium binding site [ion binding]; other site
243161001980	putative shikimate binding site; other site
243161001981	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
243161001982	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
243161001983	Tetramer interface [polypeptide binding]; other site
243161001984	active site
243161001985	FMN-binding site [chemical binding]; other site
243161001986	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
243161001987	active site
243161001988	dimer interface [polypeptide binding]; other site
243161001989	metal binding site [ion binding]; metal-binding site
243161001990	bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310
243161001991	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
243161001992	active site
243161001993	catalytic residue [active]
243161001994	dimer interface [polypeptide binding]; other site
243161001995	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
243161001996	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
243161001997	shikimate binding site; other site
243161001998	NAD(P) binding site [chemical binding]; other site
243161001999	Protein of unknown function (DUF2608); Region: DUF2608; pfam11019
243161002000	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
243161002001	Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) [Amino acid    transport and metabolism]; Region: COG1945
243161002002	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
243161002003	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
243161002004	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
243161002005	malate dehydrogenase; Region: MalateDH-SF1; TIGR01759
243161002006	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
243161002007	NAD(P) binding site [chemical binding]; other site
243161002008	LDH/MDH dimer interface [polypeptide binding]; other site
243161002009	substrate binding site [chemical binding]; other site
243161002010	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095
243161002011	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
243161002012	active site
243161002013	dimer interface [polypeptide binding]; other site
243161002014	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
243161002015	dimer interface [polypeptide binding]; other site
243161002016	active site
243161002017	GTPases [General function prediction only]; Region: HflX; COG2262
243161002018	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
243161002019	HflX GTPase family; Region: HflX; cd01878
243161002020	G1 box; other site
243161002021	GTP/Mg2+ binding site [chemical binding]; other site
243161002022	Switch I region; other site
243161002023	G2 box; other site
243161002024	G3 box; other site
243161002025	Switch II region; other site
243161002026	G4 box; other site
243161002027	G5 box; other site
243161002028	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
243161002029	putative hydrolase; Provisional; Region: PRK02113
243161002030	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243161002031	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243161002032	substrate binding pocket [chemical binding]; other site
243161002033	membrane-bound complex binding site; other site
243161002034	hinge residues; other site
243161002035	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
243161002036	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
243161002037	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
243161002038	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
243161002039	nucleotide binding site/active site [active]
243161002040	Uncharacterized conserved protein related to MYG1 family [Function unknown]; Region: COG4286
243161002041	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
243161002042	hypothetical protein; Validated; Region: PRK00647
243161002043	Protein of unknown function (DUF1207); Region: DUF1207; pfam06727
243161002044	LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542
243161002045	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243161002046	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243161002047	homodimer interface [polypeptide binding]; other site
243161002048	catalytic residue [active]
243161002049	ABC transporter substrate binding protein; Region: ABC_sub_bind; pfam04392
243161002050	prolyl-tRNA synthetase; Provisional; Region: PRK09194
243161002051	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
243161002052	dimer interface [polypeptide binding]; other site
243161002053	motif 1; other site
243161002054	active site
243161002055	motif 2; other site
243161002056	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
243161002057	putative deacylase active site [active]
243161002058	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
243161002059	active site
243161002060	motif 3; other site
243161002061	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
243161002062	anticodon binding site; other site
243161002063	heat shock gene repressor HrcA; Region: hrcA; TIGR00331
243161002064	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
243161002065	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
243161002066	dimer interface [polypeptide binding]; other site
243161002067	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
243161002068	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
243161002069	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
243161002070	nucleotide binding site [chemical binding]; other site
243161002071	NEF interaction site [polypeptide binding]; other site
243161002072	SBD interface [polypeptide binding]; other site
243161002073	Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811
243161002074	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
243161002075	RNA binding site [nucleotide binding]; other site
243161002076	RNB domain; Region: RNB; pfam00773
243161002077	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
243161002078	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
243161002079	Putative zinc ribbon domain; Region: DUF164; pfam02591
243161002080	KpsF/GutQ family protein; Region: kpsF; TIGR00393
243161002081	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
243161002082	putative active site [active]
243161002083	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
243161002084	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
243161002085	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
243161002086	E3 interaction surface; other site
243161002087	lipoyl attachment site [posttranslational modification]; other site
243161002088	e3 binding domain; Region: E3_binding; pfam02817
243161002089	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
243161002090	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
243161002091	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
243161002092	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
243161002093	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
243161002094	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
243161002095	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
243161002096	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
243161002097	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
243161002098	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243161002099	S-adenosylmethionine binding site [chemical binding]; other site
243161002100	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
243161002101	Lumazine binding domain; Region: Lum_binding; pfam00677
243161002102	Lumazine binding domain; Region: Lum_binding; pfam00677
243161002103	Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327
243161002104	ATP cone domain; Region: ATP-cone; pfam03477
243161002105	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
243161002106	Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597
243161002107	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
243161002108	amino acid carrier protein; Region: agcS; TIGR00835
243161002109	poly(A) polymerase; Region: pcnB; TIGR01942
243161002110	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
243161002111	active site
243161002112	NTP binding site [chemical binding]; other site
243161002113	metal binding triad [ion binding]; metal-binding site
243161002114	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
243161002115	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK01021
243161002116	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578
243161002117	Predicted membrane protein [Function unknown]; Region: COG3952
243161002118	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
243161002119	Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376
243161002120	Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548
243161002121	Autotransporter beta-domain; Region: Autotransporter; pfam03797
243161002122	Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548
243161002123	Autotransporter beta-domain; Region: Autotransporter; pfam03797
243161002124	Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548
243161002125	Autotransporter beta-domain; Region: Autotransporter; pfam03797
243161002126	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
243161002127	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
243161002128	intersubunit interface [polypeptide binding]; other site
243161002129	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
243161002130	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
243161002131	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
243161002132	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
243161002133	ABC-ATPase subunit  interface; other site
243161002134	dimer interface [polypeptide binding]; other site
243161002135	putative PBP binding regions; other site
243161002136	GTPase CgtA; Reviewed; Region: obgE; PRK12299
243161002137	GTP1/OBG; Region: GTP1_OBG; pfam01018
243161002138	Obg GTPase; Region: Obg; cd01898
243161002139	G1 box; other site
243161002140	GTP/Mg2+ binding site [chemical binding]; other site
243161002141	Switch I region; other site
243161002142	G2 box; other site
243161002143	G3 box; other site
243161002144	Switch II region; other site
243161002145	G4 box; other site
243161002146	G5 box; other site
243161002147	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
243161002148	Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]; Region: RplU; COG0261
243161002149	Uncharacterized conserved protein [Function unknown]; Region: COG2928
243161002150	Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137
243161002151	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
243161002152	FOG: CBS domain [General function prediction only]; Region: COG0517
243161002153	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
243161002154	Transporter associated domain; Region: CorC_HlyC; smart01091
243161002155	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
243161002156	anti sigma factor interaction site; other site
243161002157	regulatory phosphorylation site [posttranslational modification]; other site
243161002158	Protein of unknown function (DUF3604); Region: DUF3604; pfam12228
243161002159	YSIRK type signal peptide; Region: YSIRK_signal; cl04650
243161002160	hypothetical protein; Provisional; Region: PRK05926
243161002161	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
243161002162	FeS/SAM binding site; other site
243161002163	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427
243161002164	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
243161002165	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243161002166	S-adenosylmethionine binding site [chemical binding]; other site
243161002167	Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682
243161002168	diaminopimelate epimerase; Region: DapF; TIGR00652
243161002169	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
243161002170	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
243161002171	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
243161002172	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
243161002173	oligomer interface [polypeptide binding]; other site
243161002174	active site residues [active]
243161002175	serine hydroxymethyltransferase; Provisional; Region: PRK13580
243161002176	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
243161002177	dimer interface [polypeptide binding]; other site
243161002178	active site
243161002179	glycine-pyridoxal phosphate binding site [chemical binding]; other site
243161002180	folate binding site [chemical binding]; other site
243161002181	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
243161002182	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
243161002183	active site
243161002184	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
243161002185	homotrimer interaction site [polypeptide binding]; other site
243161002186	zinc binding site [ion binding]; other site
243161002187	CDP-binding sites; other site
243161002188	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
243161002189	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
243161002190	FAD binding pocket [chemical binding]; other site
243161002191	conserved FAD binding motif [chemical binding]; other site
243161002192	phosphate binding motif [ion binding]; other site
243161002193	beta-alpha-beta structure motif; other site
243161002194	NAD binding pocket [chemical binding]; other site
243161002195	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
243161002196	elongation factor G; Reviewed; Region: PRK12739
243161002197	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
243161002198	G1 box; other site
243161002199	putative GEF interaction site [polypeptide binding]; other site
243161002200	GTP/Mg2+ binding site [chemical binding]; other site
243161002201	Switch I region; other site
243161002202	G2 box; other site
243161002203	G3 box; other site
243161002204	Switch II region; other site
243161002205	G4 box; other site
243161002206	G5 box; other site
243161002207	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
243161002208	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
243161002209	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
243161002210	30S ribosomal protein S7; Validated; Region: PRK05302
243161002211	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
243161002212	S17 interaction site [polypeptide binding]; other site
243161002213	S8 interaction site; other site
243161002214	16S rRNA interaction site [nucleotide binding]; other site
243161002215	streptomycin interaction site [chemical binding]; other site
243161002216	23S rRNA interaction site [nucleotide binding]; other site
243161002217	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
243161002218	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
243161002219	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
243161002220	protein binding site [polypeptide binding]; other site
243161002221	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
243161002222	Catalytic dyad [active]
243161002223	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
243161002224	Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA); Region: CRPA; pfam05745
243161002225	Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504
243161002226	Domain of unknown function DUF11; Region: DUF11; pfam01345
243161002227	Domain of unknown function DUF11; Region: DUF11; pfam01345
243161002228	Chlamydia cysteine-rich outer membrane protein 3; Region: Chlam_OMP3; pfam03503
243161002229	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
243161002230	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
243161002231	HIGH motif; other site
243161002232	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
243161002233	active site
243161002234	KMSKS motif; other site
243161002235	Helix-turn-helix domain; Region: HTH_17; pfam12728
243161002236	Helix-turn-helix domain; Region: HTH_17; pfam12728
243161002237	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
243161002238	DHH family; Region: DHH; pfam01368
243161002239	DHHA1 domain; Region: DHHA1; pfam02272
243161002240	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911
243161002241	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
243161002242	Protein export membrane protein; Region: SecD_SecF; pfam02355
243161002243	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14840
243161002244	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
243161002245	catalytic residue [active]
243161002246	putative FPP diphosphate  binding site; other site
243161002247	putative FPP binding hydrophobic cleft; other site
243161002248	dimer interface [polypeptide binding]; other site
243161002249	putative IPP diphosphate binding site; other site
243161002250	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
243161002251	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
243161002252	cytidylate kinase; Provisional; Region: cmk; PRK00023
243161002253	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
243161002254	CMP-binding site; other site
243161002255	The sites determining sugar specificity; other site
243161002256	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
243161002257	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
243161002258	putative acyl-acceptor binding pocket; other site
243161002259	arginine-tRNA ligase; Region: PLN02286
243161002260	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
243161002261	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
243161002262	active site
243161002263	HIGH motif; other site
243161002264	KMSK motif region; other site
243161002265	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
243161002266	tRNA binding surface [nucleotide binding]; other site
243161002267	anticodon binding site; other site
243161002268	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
243161002269	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
243161002270	hinge; other site
243161002271	active site
243161002272	Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577
243161002273	Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577
243161002274	Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577
243161002275	Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577
243161002276	DNA-binding regulatory protein, YebC/PmpR family; Region: TIGR01033
243161002277	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
243161002278	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243161002279	Coenzyme A binding pocket [chemical binding]; other site
243161002280	SWI complex, BAF60b domains; Region: SWIB; smart00151
243161002281	phosphodiesterase YaeI; Provisional; Region: PRK11340
243161002282	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
243161002283	putative active site [active]
243161002284	putative metal binding site [ion binding]; other site
243161002285	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
243161002286	substrate binding site; other site
243161002287	dimer interface; other site
243161002288	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
243161002289	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243161002290	motif II; other site
243161002291	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
243161002292	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
243161002293	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243161002294	dimer interface [polypeptide binding]; other site
243161002295	phosphorylation site [posttranslational modification]
243161002296	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243161002297	ATP binding site [chemical binding]; other site
243161002298	Mg2+ binding site [ion binding]; other site
243161002299	G-X-G motif; other site
243161002300	Response regulator receiver domain; Region: Response_reg; pfam00072
243161002301	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243161002302	active site
243161002303	phosphorylation site [posttranslational modification]
243161002304	intermolecular recognition site; other site
243161002305	dimerization interface [polypeptide binding]; other site
243161002306	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243161002307	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
243161002308	Walker A motif; other site
243161002309	ATP binding site [chemical binding]; other site
243161002310	Walker B motif; other site
243161002311	arginine finger; other site
243161002312	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588
243161002313	Recombination protein O N terminal; Region: RecO_N; pfam11967
243161002314	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381
243161002315	Recombination protein O C terminal; Region: RecO_C; pfam02565
243161002316	Uncharacterized conserved protein [Function unknown]; Region: COG1723
243161002317	hypothetical protein; Provisional; Region: PRK14377
243161002318	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
243161002319	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
243161002320	putative tRNA-binding site [nucleotide binding]; other site
243161002321	B3/4 domain; Region: B3_4; pfam03483
243161002322	tRNA synthetase B5 domain; Region: B5; pfam03484
243161002323	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
243161002324	dimer interface [polypeptide binding]; other site
243161002325	motif 1; other site
243161002326	motif 3; other site
243161002327	motif 2; other site
243161002328	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
243161002329	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
243161002330	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
243161002331	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
243161002332	DNA binding site [nucleotide binding]
243161002333	active site
243161002334	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
243161002335	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243161002336	dimer interface [polypeptide binding]; other site
243161002337	conserved gate region; other site
243161002338	putative PBP binding loops; other site
243161002339	ABC-ATPase subunit interface; other site
243161002340	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
243161002341	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
243161002342	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
243161002343	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
243161002344	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
243161002345	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
243161002346	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
243161002347	putative active site [active]
243161002348	putative metal binding site [ion binding]; other site
243161002349	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
243161002350	ferrochelatase; Reviewed; Region: hemH; PRK00035
243161002351	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
243161002352	C-terminal domain interface [polypeptide binding]; other site
243161002353	active site
243161002354	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
243161002355	active site
243161002356	N-terminal domain interface [polypeptide binding]; other site
243161002357	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
243161002358	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243161002359	substrate binding pocket [chemical binding]; other site
243161002360	membrane-bound complex binding site; other site
243161002361	hinge residues; other site
243161002362	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
243161002363	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243161002364	S-adenosylmethionine binding site [chemical binding]; other site
243161002365	Predicted phosphohydrolase [General function prediction only]; Region: COG1768
243161002366	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
243161002367	ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448
243161002368	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
243161002369	ligand binding site; other site
243161002370	oligomer interface; other site
243161002371	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
243161002372	N-terminal domain interface [polypeptide binding]; other site
243161002373	sulfate 1 binding site; other site
243161002374	transcription termination factor Rho; Region: rho; TIGR00767
243161002375	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
243161002376	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
243161002377	RNA binding site [nucleotide binding]; other site
243161002378	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
243161002379	multimer interface [polypeptide binding]; other site
243161002380	Walker A motif; other site
243161002381	ATP binding site [chemical binding]; other site
243161002382	Walker B motif; other site
243161002383	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
243161002384	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
243161002385	CoA-binding site [chemical binding]; other site
243161002386	ATP-binding [chemical binding]; other site
243161002387	DNA polymerase I; Provisional; Region: PRK05755
243161002388	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
243161002389	active site
243161002390	metal binding site 1 [ion binding]; metal-binding site
243161002391	putative 5' ssDNA interaction site; other site
243161002392	metal binding site 3; metal-binding site
243161002393	metal binding site 2 [ion binding]; metal-binding site
243161002394	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
243161002395	putative DNA binding site [nucleotide binding]; other site
243161002396	putative metal binding site [ion binding]; other site
243161002397	3'-5' exonuclease; Region: 35EXOc; smart00474
243161002398	active site
243161002399	substrate binding site [chemical binding]; other site
243161002400	catalytic site [active]
243161002401	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
243161002402	active site
243161002403	DNA binding site [nucleotide binding]
243161002404	catalytic site [active]
243161002405	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
243161002406	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
243161002407	tandem repeat interface [polypeptide binding]; other site
243161002408	oligomer interface [polypeptide binding]; other site
243161002409	active site residues [active]
243161002410	TLC ATP/ADP transporter; Region: TLC; pfam03219
243161002411	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
243161002412	replicative DNA helicase; Provisional; Region: PRK06321
243161002413	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
243161002414	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
243161002415	Walker A motif; other site
243161002416	ATP binding site [chemical binding]; other site
243161002417	Walker B motif; other site
243161002418	DNA binding loops [nucleotide binding]
243161002419	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
243161002420	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
243161002421	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
243161002422	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
243161002423	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
243161002424	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
243161002425	active site
243161002426	multimer interface [polypeptide binding]; other site
243161002427	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
243161002428	RuvA N terminal domain; Region: RuvA_N; pfam01330
243161002429	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
243161002430	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
243161002431	active site
243161002432	putative DNA-binding cleft [nucleotide binding]; other site
243161002433	dimer interface [polypeptide binding]; other site
243161002434	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
243161002435	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
243161002436	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
243161002437	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
243161002438	Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203
243161002439	DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027
243161002440	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
243161002441	alphaNTD - beta interaction site [polypeptide binding]; other site
243161002442	alphaNTD homodimer interface [polypeptide binding]; other site
243161002443	alphaNTD - beta' interaction site [polypeptide binding]; other site
243161002444	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
243161002445	30S ribosomal protein S11; Validated; Region: PRK05309
243161002446	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
243161002447	30S ribosomal protein S13; Region: bact_S13; TIGR03631
243161002448	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
243161002449	SecY translocase; Region: SecY; pfam00344
243161002450	ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071
243161002451	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
243161002452	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
243161002453	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
243161002454	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
243161002455	5S rRNA interface [nucleotide binding]; other site
243161002456	23S rRNA interface [nucleotide binding]; other site
243161002457	L5 interface [polypeptide binding]; other site
243161002458	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
243161002459	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
243161002460	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
243161002461	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
243161002462	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
243161002463	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
243161002464	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
243161002465	Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Region: RplX; COG0198
243161002466	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
243161002467	RNA binding site [nucleotide binding]; other site
243161002468	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
243161002469	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
243161002470	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
243161002471	23S rRNA interface [nucleotide binding]; other site
243161002472	putative translocon interaction site; other site
243161002473	signal recognition particle (SRP54) interaction site; other site
243161002474	L23 interface [polypeptide binding]; other site
243161002475	trigger factor interaction site; other site
243161002476	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
243161002477	23S rRNA interface [nucleotide binding]; other site
243161002478	5S rRNA interface [nucleotide binding]; other site
243161002479	putative antibiotic binding site [chemical binding]; other site
243161002480	L25 interface [polypeptide binding]; other site
243161002481	L27 interface [polypeptide binding]; other site
243161002482	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
243161002483	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
243161002484	G-X-X-G motif; other site
243161002485	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
243161002486	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
243161002487	putative translocon binding site; other site
243161002488	protein-rRNA interface [nucleotide binding]; other site
243161002489	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
243161002490	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
243161002491	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
243161002492	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
243161002493	Ribosomal protein L23 [Translation, ribosomal structure and biogenesis]; Region: RplW; COG0089
243161002494	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
243161002495	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
243161002496	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
243161002497	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
243161002498	putative active site [active]
243161002499	substrate binding site [chemical binding]; other site
243161002500	putative cosubstrate binding site; other site
243161002501	catalytic site [active]
243161002502	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
243161002503	substrate binding site [chemical binding]; other site
243161002504	Acyl-[acyl carrier protein]; Region: LpxA; COG1043
243161002505	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
243161002506	active site
243161002507	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
243161002508	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774
243161002509	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
243161002510	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
243161002511	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
243161002512	putative active site [active]
243161002513	catalytic triad [active]
243161002514	putative dimer interface [polypeptide binding]; other site
243161002515	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
243161002516	DNA polymerase III subunit epsilon; Validated; Region: PRK06310
243161002517	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
243161002518	active site
243161002519	catalytic site [active]
243161002520	substrate binding site [chemical binding]; other site
243161002521	Protein of unknown function (DUF3820); Region: DUF3820; cl01411
243161002522	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367
243161002523	Protein of unknown function (DUF2709); Region: DUF2709; pfam10915
243161002524	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
243161002525	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
243161002526	catalytic residues [active]
243161002527	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
243161002528	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
243161002529	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
243161002530	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
243161002531	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
243161002532	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
243161002533	dimer interface [polypeptide binding]; other site
243161002534	anticodon binding site; other site
243161002535	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
243161002536	homodimer interface [polypeptide binding]; other site
243161002537	motif 1; other site
243161002538	active site
243161002539	motif 2; other site
243161002540	GAD domain; Region: GAD; pfam02938
243161002541	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
243161002542	active site
243161002543	motif 3; other site
243161002544	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
243161002545	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
243161002546	dimer interface [polypeptide binding]; other site
243161002547	motif 1; other site
243161002548	active site
243161002549	motif 2; other site
243161002550	motif 3; other site
243161002551	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
243161002552	anticodon binding site; other site
243161002553	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
243161002554	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243161002555	putative substrate translocation pore; other site
243161002556	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243161002557	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
243161002558	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
243161002559	active site
243161002560	PHP Thumb interface [polypeptide binding]; other site
243161002561	metal binding site [ion binding]; metal-binding site
243161002562	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
243161002563	generic binding surface I; other site
243161002564	generic binding surface II; other site
243161002565	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243161002566	active site
243161002567	TPR repeat; Region: TPR_11; pfam13414
243161002568	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
243161002569	binding surface
243161002570	TPR motif; other site
243161002571	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
243161002572	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
243161002573	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
243161002574	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
243161002575	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
243161002576	Methyltransferase domain; Region: Methyltransf_31; pfam13847
243161002577	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243161002578	S-adenosylmethionine binding site [chemical binding]; other site
243161002579	Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114
243161002580	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
243161002581	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243161002582	ATP binding site [chemical binding]; other site
243161002583	putative Mg++ binding site [ion binding]; other site
243161002584	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243161002585	ATP-binding site [chemical binding]; other site
243161002586	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
243161002587	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
243161002588	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
243161002589	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
243161002590	lipoate synthase; Region: lipA; TIGR00510
243161002591	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243161002592	FeS/SAM binding site; other site
243161002593	Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669
243161002594	type III secretion system protein; Validated; Region: PRK06328
243161002595	Flagellar assembly protein FliH; Region: FliH; pfam02108
243161002596	type III secretion system protein; Reviewed; Region: PRK09617
243161002597	Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794
243161002598	Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791
243161002599	Protein of unknown function (DUF1494); Region: DUF1494; pfam07379
243161002600	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
243161002601	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
243161002602	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
243161002603	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
243161002604	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
243161002605	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
243161002606	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
243161002607	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
243161002608	Walker A motif; other site
243161002609	ATP binding site [chemical binding]; other site
243161002610	Walker B motif; other site
243161002611	Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450
243161002612	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
243161002613	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
243161002614	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
243161002615	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
243161002616	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
243161002617	active site
243161002618	DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323
243161002619	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243161002620	ATP binding site [chemical binding]; other site
243161002621	Mg2+ binding site [ion binding]; other site
243161002622	G-X-G motif; other site
243161002623	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
243161002624	ATP binding site [chemical binding]; other site
243161002625	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
243161002626	type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552
243161002627	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243161002628	binding surface
243161002629	TPR motif; other site
243161002630	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
243161002631	EamA-like transporter family; Region: EamA; pfam00892
243161002632	EamA-like transporter family; Region: EamA; pfam00892
243161002633	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
243161002634	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cd01616
243161002635	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
243161002636	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
243161002637	active site
243161002638	dimer interface [polypeptide binding]; other site
243161002639	motif 1; other site
243161002640	motif 2; other site
243161002641	motif 3; other site
243161002642	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
243161002643	anticodon binding site; other site
243161002644	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
243161002645	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
243161002646	Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677
243161002647	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
243161002648	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
243161002649	active site
243161002650	HIGH motif; other site
243161002651	dimer interface [polypeptide binding]; other site
243161002652	KMSKS motif; other site
243161002653	excinuclease ABC subunit B; Provisional; Region: PRK05298
243161002654	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243161002655	ATP binding site [chemical binding]; other site
243161002656	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243161002657	nucleotide binding region [chemical binding]; other site
243161002658	ATP-binding site [chemical binding]; other site
243161002659	Ultra-violet resistance protein B; Region: UvrB; pfam12344
243161002660	UvrB/uvrC motif; Region: UVR; pfam02151
243161002661	enolase; Provisional; Region: eno; PRK00077
243161002662	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
243161002663	dimer interface [polypeptide binding]; other site
243161002664	metal binding site [ion binding]; metal-binding site
243161002665	substrate binding pocket [chemical binding]; other site
243161002666	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
243161002667	HAMP domain; Region: HAMP; pfam00672
243161002668	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
243161002669	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
243161002670	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
243161002671	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
243161002672	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
243161002673	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
243161002674	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
243161002675	L-aspartate oxidase; Provisional; Region: PRK06175
243161002676	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
243161002677	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
243161002678	putative Iron-sulfur protein interface [polypeptide binding]; other site
243161002679	proximal heme binding site [chemical binding]; other site
243161002680	putative dimer interface [polypeptide binding]; other site
243161002681	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
243161002682	proximal heme binding site [chemical binding]; other site
243161002683	Iron-sulfur protein interface; other site
243161002684	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
243161002685	active site
243161002686	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
243161002687	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
243161002688	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
243161002689	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
243161002690	DsbD alpha interface [polypeptide binding]; other site
243161002691	catalytic residues [active]
243161002692	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
243161002693	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
243161002694	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
243161002695	translocation protein TolB; Provisional; Region: tolB; PRK01029
243161002696	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
243161002697	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
243161002698	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
243161002699	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
243161002700	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
243161002701	ligand binding site [chemical binding]; other site
243161002702	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
243161002703	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
243161002704	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243161002705	flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688
243161002706	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
243161002707	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
243161002708	dimer interface [polypeptide binding]; other site
243161002709	decamer (pentamer of dimers) interface [polypeptide binding]; other site
243161002710	catalytic triad [active]
243161002711	peroxidatic and resolving cysteines [active]
243161002712	C-terminal domain of 1-Cys peroxiredoxin; Region: 1-cysPrx_C; pfam10417
243161002713	Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459
243161002714	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
243161002715	Protein of unknown function (DUF1343); Region: DUF1343; cl01598
243161002716	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
243161002717	active site
243161002718	dimerization interface [polypeptide binding]; other site
243161002719	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
243161002720	ligand binding site [chemical binding]; other site
243161002721	active site
243161002722	UGI interface [polypeptide binding]; other site
243161002723	catalytic site [active]
243161002724	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
243161002725	Part of AAA domain; Region: AAA_19; pfam13245
243161002726	Family description; Region: UvrD_C_2; pfam13538
243161002727	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
243161002728	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
243161002729	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
243161002730	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
243161002731	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
243161002732	GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478
243161002733	putative folate metabolism gamma-glutamate ligase; Region: intra_fol_E_lig; TIGR04132
243161002734	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
243161002735	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
243161002736	folate binding site [chemical binding]; other site
243161002737	NADP+ binding site [chemical binding]; other site
243161002738	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
243161002739	catalytic center binding site [active]
243161002740	ATP binding site [chemical binding]; other site
243161002741	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
243161002742	dihydropteroate synthase; Region: DHPS; TIGR01496
243161002743	substrate binding pocket [chemical binding]; other site
243161002744	dimer interface [polypeptide binding]; other site
243161002745	inhibitor binding site; inhibition site
243161002746	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
243161002747	homooctamer interface [polypeptide binding]; other site
243161002748	active site
243161002749	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
243161002750	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
243161002751	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
243161002752	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
243161002753	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
243161002754	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
243161002755	DNA binding residues [nucleotide binding]
243161002756	Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785
243161002757	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
243161002758	Effector from type III secretion system; Region: Effector_1; pfam04518
243161002759	Effector from type III secretion system; Region: Effector_1; pfam04518
243161002760	Effector from type III secretion system; Region: Effector_1; pfam04518
243161002761	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
243161002762	MviN-like protein; Region: MVIN; pfam03023
243161002763	endonuclease IV; Provisional; Region: PRK01060
243161002764	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
243161002765	AP (apurinic/apyrimidinic) site pocket; other site
243161002766	DNA interaction; other site
243161002767	Metal-binding active site; metal-binding site
243161002768	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
243161002769	ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017
243161002770	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
243161002771	RNA binding surface [nucleotide binding]; other site
243161002772	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
243161002773	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
243161002774	active site residue [active]
243161002775	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
243161002776	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
243161002777	substrate binding pocket [chemical binding]; other site
243161002778	chain length determination region; other site
243161002779	substrate-Mg2+ binding site; other site
243161002780	catalytic residues [active]
243161002781	aspartate-rich region 1; other site
243161002782	active site lid residues [active]
243161002783	aspartate-rich region 2; other site
243161002784	Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636
243161002785	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
243161002786	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243161002787	DNA binding site [nucleotide binding]
243161002788	Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351
243161002789	Thymidylate synthase complementing protein; Region: Thy1; cl03630