-- dump date 20140619_031519 -- class Genbank::misc_feature -- table misc_feature_note -- id note 471472000001 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 471472000002 dimer interface [polypeptide binding]; other site 471472000003 allosteric magnesium binding site [ion binding]; other site 471472000004 active site 471472000005 aspartate-rich active site metal binding site; other site 471472000006 Schiff base residues; other site 471472000007 PS00169 Delta-aminolevulinic acid dehydratase active site. 471472000008 NADH:ubiquinone oxidoreductase, Na(+)-translocating, A subunit; Region: nqrA; TIGR01936 471472000009 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 471472000010 lipoyl-biotinyl attachment site [posttranslational modification]; other site 471472000011 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 471472000012 Putative bacteriophage terminase small subunit; Region: Phage_term_sma; pfam07141 471472000013 transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330 471472000014 Uncharacterized N-terminal domain of the transcription elongation factor GreA [Function unknown]; Region: COG1747 471472000015 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 471472000016 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 471472000017 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 471472000018 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471472000019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471472000020 homodimer interface [polypeptide binding]; other site 471472000021 catalytic residue [active] 471472000022 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 471472000023 rod shape-determining protein MreC; Provisional; Region: PRK14872 471472000024 1 probable transmembrane helix predicted for CTL0006 by TMHMM2.0 at aa 13-30 471472000025 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 471472000026 Part of AAA domain; Region: AAA_19; pfam13245 471472000027 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 471472000028 PS00017 ATP/GTP-binding site motif A (P-loop). 471472000029 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 471472000030 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl19914 471472000031 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471472000032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471472000033 putative substrate translocation pore; other site 471472000034 12 probable transmembrane helices predicted for CTL0009 by TMHMM2.0 at aa 13-35, 48-70, 77-99,105-127,140-162, 172-194, 227-249, 264-286, 291-313,318-340,353-375 and 385-404 471472000035 1 probable transmembrane helix predicted for CTL0010 by TMHMM2.0 at aa 182-204 471472000036 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 471472000037 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 471472000038 active site 471472000039 interdomain interaction site; other site 471472000040 putative metal-binding site [ion binding]; other site 471472000041 nucleotide binding site [chemical binding]; other site 471472000042 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 471472000043 domain I; other site 471472000044 DNA binding groove [nucleotide binding] 471472000045 phosphate binding site [ion binding]; other site 471472000046 domain II; other site 471472000047 domain III; other site 471472000048 nucleotide binding site [chemical binding]; other site 471472000049 catalytic site [active] 471472000050 domain IV; other site 471472000051 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 471472000052 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 471472000053 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 471472000054 SWI complex, BAF60b domains; Region: SWIB; smart00151 471472000055 PS00396 Prokaryotic DNA topoisomerase I active site. 471472000056 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 471472000057 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 471472000058 FMN binding site [chemical binding]; other site 471472000059 active site 471472000060 catalytic residues [active] 471472000061 substrate binding site [chemical binding]; other site 471472000062 PS01136 Uncharacterized protein family UPF0034 signature. 471472000063 Predicted integral membrane protein [Function unknown]; Region: COG0762 471472000064 2 probable transmembrane helices predicted for CTL0013 by TMHMM2.0 at aa 4-26 and 64-86 471472000065 1 probable transmembrane helix predicted for CTL0015 by TMHMM2.0 at aa 5-27 471472000066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 471472000067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 471472000068 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 471472000069 recombinase A; Provisional; Region: recA; PRK09354 471472000070 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 471472000071 hexamer interface [polypeptide binding]; other site 471472000072 Walker A motif; other site 471472000073 ATP binding site [chemical binding]; other site 471472000074 Walker B motif; other site 471472000075 PS00017 ATP/GTP-binding site motif A (P-loop). 471472000076 PS00321 recA signature. 471472000077 Protein of unknown function (DUF1347); Region: DUF1347; pfam07079 471472000078 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472000079 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 471472000080 AAA domain; Region: AAA_30; pfam13604 471472000081 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 471472000082 PS00017 ATP/GTP-binding site motif A (P-loop). 471472000083 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 471472000084 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 471472000085 Walker A/P-loop; other site 471472000086 ATP binding site [chemical binding]; other site 471472000087 Q-loop/lid; other site 471472000088 ABC transporter signature motif; other site 471472000089 Walker B; other site 471472000090 D-loop; other site 471472000091 H-loop/switch region; other site 471472000092 PS00211 ABC transporters family signature. 471472000093 PS00017 ATP/GTP-binding site motif A (P-loop). 471472000094 Protein of unknown function (DUF1137); Region: DUF1137; pfam06587 471472000095 1 probable transmembrane helix predicted for CTL0023 by TMHMM2.0 at aa 5-27 471472000096 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472000097 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 471472000098 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 471472000099 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471472000100 RNA binding surface [nucleotide binding]; other site 471472000101 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 471472000102 active site 471472000103 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cd02409 471472000104 G-X-X-G motif; other site 471472000105 DNA topoisomerase IV subunit A; Provisional; Region: PRK09630 471472000106 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 471472000107 CAP-like domain; other site 471472000108 active site 471472000109 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 471472000110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471472000111 ATP binding site [chemical binding]; other site 471472000112 Mg2+ binding site [ion binding]; other site 471472000113 G-X-G motif; other site 471472000114 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 471472000115 ATP binding site [chemical binding]; other site 471472000116 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 471472000117 active site 471472000118 putative metal-binding site [ion binding]; other site 471472000119 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 471472000120 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 471472000121 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 471472000122 NAD(P) binding pocket [chemical binding]; other site 471472000123 HMMPfam hit to PF05201, Glutamyl-tRNAGlu reductase,N-terminal domai, score 3.9e-54 471472000124 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 471472000125 HMMPfam hit to PF05932, Tir chaperone protein (CesT), score 8.1e-35 471472000126 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471472000127 phosphopeptide binding site; other site 471472000128 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 471472000129 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471472000130 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 471472000131 phosphopeptide binding site; other site 471472000132 HMMPfam hit to PF00498, FHA domain, score 6.6e-11 471472000133 HMMPfam hit to PF00498, FHA domain, score 9e-11 471472000134 1 probable transmembrane helix predicted for CTL0033 by TMHMM2.0 at aa 530-552 471472000135 HMMPfam hit to PF04972, Putative phospholipid-binding domain, score 3.3e-10 471472000136 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471472000137 binding surface 471472000138 Tetratricopeptide repeat; Region: TPR_16; pfam13432 471472000139 TPR motif; other site 471472000140 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 0.0037 471472000141 type III secretion system ATPase; Provisional; Region: PRK06315 471472000142 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 471472000143 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 471472000144 Walker A motif/ATP binding site; other site 471472000145 Walker B motif; other site 471472000146 HMMPfam hit to PF02874, ATP synthase alpha/beta family, beta-ba, score 9.6e-07 471472000147 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleot, score 9.1e-125 471472000148 PS00017 ATP/GTP-binding site motif A (P-loop). 471472000149 PS00152 ATP synthase alpha and beta subunits signature. 471472000150 Autophagy protein Apg6; Region: APG6; pfam04111 471472000151 type III secretion system protein; Validated; Region: PRK05933 471472000152 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 471472000153 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) prot, score 0.00025 471472000154 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471472000155 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471472000156 active site 471472000157 ATP binding site [chemical binding]; other site 471472000158 substrate binding site [chemical binding]; other site 471472000159 activation loop (A-loop); other site 471472000160 HMMPfam hit to PF00069, Protein kinase domain,score 6.6e-29 471472000161 PS00108 Serine/Threonine protein kinases active-site signature. 471472000162 MAP7 (E-MAP-115) family; Region: MAP7; pfam05672 471472000163 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 471472000164 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 471472000165 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 471472000166 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 471472000167 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 471472000168 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 2.5e-09 471472000169 PS00591 Glycosyl hydrolases family 10 active site. 471472000170 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 2.8e-09 471472000171 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 3.2e-09 471472000172 HMMPfam hit to PF00263, Bacterial type II and III secretion system, score 2.8e-72 471472000173 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 471472000174 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 471472000175 ADP binding site [chemical binding]; other site 471472000176 phosphagen binding site; other site 471472000177 substrate specificity loop; other site 471472000178 HMMPfam hit to PF00217, ATP:guanido phosphotransferase, C-term, score 9.2e-05 471472000179 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 471472000180 UvrB/uvrC motif; Region: UVR; pfam02151 471472000181 HMMPfam hit to PF02151, UvrB/uvrC motif, score 4.9e-09 471472000182 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 471472000183 hinge region; other site 471472000184 HMMPfam hit to PF01765, Ribosome recycling factor,score 4.1e-85 471472000185 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 471472000186 putative nucleotide binding site [chemical binding]; other site 471472000187 uridine monophosphate binding site [chemical binding]; other site 471472000188 homohexameric interface [polypeptide binding]; other site 471472000189 HMMPfam hit to PF00696, Amino acid kinase family,score 2.3e-51 471472000190 Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]; Region: Tsf; COG0264 471472000191 UBA/TS-N domain; Region: UBA; pfam00627 471472000192 HMMPfam hit to PF00889, Elongation factor TS, score 9.6e-105 471472000193 PS01127 Elongation factor Ts signature 2. 471472000194 HMMPfam hit to PF00627, UBA/TS-N domain, score 9.2e-09 471472000195 PS01126 Elongation factor Ts signature 1. 471472000196 40S ribosomal protein SA; Provisional; Region: PTZ00254 471472000197 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 471472000198 rRNA interaction site [nucleotide binding]; other site 471472000199 S8 interaction site; other site 471472000200 putative laminin-1 binding site; other site 471472000201 HMMPfam hit to PF00318, Ribosomal protein S2, score 1.2e-84 471472000202 PS00963 Ribosomal protein S2 signature 2. 471472000203 PS00962 Ribosomal protein S2 signature 1. 471472000204 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 471472000205 HMMPfam hit to PF01308, Chlamydia major outer membrane protein, score 8.2e-268 471472000206 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 471472000207 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 471472000208 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 471472000209 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 471472000210 1 probable transmembrane helix predicted for CTL0051 by TMHMM2.0 at aa 17-39 471472000211 HMMPfam hit to PF03717, Penicillin-binding Protein dimerisatio, score 3e-52 471472000212 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 4.6e-06 471472000213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471472000214 TPR motif; other site 471472000215 Tetratricopeptide repeat; Region: TPR_16; pfam13432 471472000216 binding surface 471472000217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471472000218 binding surface 471472000219 TPR motif; other site 471472000220 TPR repeat; Region: TPR_11; pfam13414 471472000221 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471472000222 binding surface 471472000223 TPR repeat; Region: TPR_11; pfam13414 471472000224 TPR motif; other site 471472000225 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 0.0015 471472000226 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 7.9e-07 471472000227 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 0.059 471472000228 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 0.00011 471472000229 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 3e-06 471472000230 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 2.5e-05 471472000231 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 471472000232 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 471472000233 HMMPfam hit to PF01458, Uncharacterized protein family (UPF0051), score 6.4e-117 471472000234 FeS assembly ATPase SufC; Region: sufC; TIGR01978 471472000235 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 471472000236 Walker A/P-loop; other site 471472000237 ATP binding site [chemical binding]; other site 471472000238 Q-loop/lid; other site 471472000239 ABC transporter signature motif; other site 471472000240 Walker B; other site 471472000241 D-loop; other site 471472000242 H-loop/switch region; other site 471472000243 HMMPfam hit to PF00005, ABC transporter, score 6.5e-25 471472000244 PS00017 ATP/GTP-binding site motif A (P-loop). 471472000245 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 471472000246 FeS assembly protein SufD; Region: sufD; TIGR01981 471472000247 HMMPfam hit to PF01458, Uncharacterized protein family (UPF0051), score 1.3e-10 471472000248 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 471472000249 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471472000250 catalytic residue [active] 471472000251 HMMPfam hit to PF00266, Aminotransferase class-V,score 3.2e-197 471472000252 HMMPfam hit to PF01212, Beta-eliminating lyase,score 0.0031 471472000253 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 471472000254 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 471472000255 ParB-like nuclease domain; Region: ParBc; pfam02195 471472000256 KorB domain; Region: KorB; pfam08535 471472000257 HMMPfam hit to PF02195, ParB-like nuclease domain,score 9.8e-36 471472000258 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471472000259 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 471472000260 Walker A/P-loop; other site 471472000261 ATP binding site [chemical binding]; other site 471472000262 Q-loop/lid; other site 471472000263 ABC transporter signature motif; other site 471472000264 Walker B; other site 471472000265 D-loop; other site 471472000266 H-loop/switch region; other site 471472000267 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471472000268 HMMPfam hit to PF00005, ABC transporter, score 6.5e-46 471472000269 PS00211 ABC transporters family signature. 471472000270 PS00017 ATP/GTP-binding site motif A (P-loop). 471472000271 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471472000272 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471472000273 Walker A/P-loop; other site 471472000274 ATP binding site [chemical binding]; other site 471472000275 Q-loop/lid; other site 471472000276 ABC transporter signature motif; other site 471472000277 Walker B; other site 471472000278 D-loop; other site 471472000279 H-loop/switch region; other site 471472000280 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471472000281 HMMPfam hit to PF08352, Oligopeptide/dipeptide transporter, C-termi, score 5.8e-21 471472000282 HMMPfam hit to PF00005, ABC transporter, score 2.2e-50 471472000283 PS00211 ABC transporters family signature. 471472000284 PS00017 ATP/GTP-binding site motif A (P-loop). 471472000285 TIGR00153 family protein; Region: TIGR00153 471472000286 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 471472000287 HMMPfam hit to PF01865, Protein of unknown function DUF47, score 3.3e-111 471472000288 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 471472000289 10 probable transmembrane helices predicted for CTL0061 by TMHMM2.0 at aa 2-21, 36-58, 101-123,138-160,181-203, 208-230, 260-282, 310-332, 362-384 and 399-421 471472000290 HMMPfam hit to PF01384, Phosphate transporter family, score 8.1e-191 471472000291 PS00211 ABC transporters family signature. 471472000292 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 471472000293 substrate binding site [chemical binding]; other site 471472000294 hinge regions; other site 471472000295 ADP binding site [chemical binding]; other site 471472000296 catalytic site [active] 471472000297 HMMPfam hit to PF00162, Phosphoglycerate kinase,score 8.8e-182 471472000298 PS00111 Phosphoglycerate kinase signature. 471472000299 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 471472000300 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471472000301 minor groove reading motif; other site 471472000302 helix-hairpin-helix signature motif; other site 471472000303 substrate binding pocket [chemical binding]; other site 471472000304 active site 471472000305 HMMPfam hit to PF00730, HhH-GPD superfamily base excision DNA repair, score 8.2e-22 471472000306 HMMPfam hit to PF00633, Helix-hairpin-helix motif,score 2.1e-05 471472000307 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 471472000308 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 471472000309 trmE is a tRNA modification GTPase; Region: trmE; cd04164 471472000310 G1 box; other site 471472000311 GTP/Mg2+ binding site [chemical binding]; other site 471472000312 Switch I region; other site 471472000313 G2 box; other site 471472000314 Switch II region; other site 471472000315 G3 box; other site 471472000316 G4 box; other site 471472000317 G5 box; other site 471472000318 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 471472000319 HMMPfam hit to PF01926, GTPase of unknown function,score 3e-41 471472000320 PS00017 ATP/GTP-binding site motif A (P-loop). 471472000321 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 471472000322 HMMPfam hit to PF02666, Phosphatidylserine decarboxylase, score 1e-113 471472000323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471472000324 binding surface 471472000325 TPR motif; other site 471472000326 1 probable transmembrane helix predicted for CTL0069 by TMHMM2.0 at aa 2-19 471472000327 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472000328 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 0.00073 471472000329 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 471472000330 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471472000331 ATP binding site [chemical binding]; other site 471472000332 putative Mg++ binding site [ion binding]; other site 471472000333 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 471472000334 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471472000335 nucleotide binding region [chemical binding]; other site 471472000336 ATP-binding site [chemical binding]; other site 471472000337 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 471472000338 HMMPfam hit to PF07517, SecA DEAD-like domain,score 6.2e-162 471472000339 HMMPfam hit to PF01043, SecA preprotein cross-linking domain, score 4.5e-16 471472000340 PS01312 Protein secA signatures. 471472000341 HMMPfam hit to PF07516, SecA Wing and Scaffold domain, score 8.5e-42 471472000342 Predicted GTPases [General function prediction only]; Region: COG1160 471472000343 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 471472000344 G1 box; other site 471472000345 GTP/Mg2+ binding site [chemical binding]; other site 471472000346 Switch I region; other site 471472000347 G2 box; other site 471472000348 Switch II region; other site 471472000349 G3 box; other site 471472000350 G4 box; other site 471472000351 G5 box; other site 471472000352 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 471472000353 G1 box; other site 471472000354 GTP/Mg2+ binding site [chemical binding]; other site 471472000355 Switch I region; other site 471472000356 G2 box; other site 471472000357 G3 box; other site 471472000358 Switch II region; other site 471472000359 G4 box; other site 471472000360 G5 box; other site 471472000361 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 471472000362 HMMPfam hit to PF01926, GTPase of unknown function,score 8.5e-45 471472000363 PS00017 ATP/GTP-binding site motif A (P-loop). 471472000364 HMMPfam hit to PF01926, GTPase of unknown function,score 4.3e-41 471472000365 PS00017 ATP/GTP-binding site motif A (P-loop). 471472000366 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 471472000367 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 471472000368 active site 471472000369 NTP binding site [chemical binding]; other site 471472000370 metal binding triad [ion binding]; metal-binding site 471472000371 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 471472000372 HMMPfam hit to PF01743, Poly A polymerase family,score 3.1e-78 471472000373 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 471472000374 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 471472000375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471472000376 Walker A motif; other site 471472000377 ATP binding site [chemical binding]; other site 471472000378 Walker B motif; other site 471472000379 arginine finger; other site 471472000380 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 471472000381 HMMPfam hit to PF00004, ATPase family associated with various cell, score 1.3e-05 471472000382 HMMPfam hit to PF07724, ATPase family associated with various cell, score 1e-79 471472000383 PS00017 ATP/GTP-binding site motif A (P-loop). 471472000384 HMMPfam hit to PF06689, ClpX C4-type zinc finger,score 1.6e-21 471472000385 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471472000386 oligomer interface [polypeptide binding]; other site 471472000387 active site residues [active] 471472000388 HMMPfam hit to PF00574, Clp protease, score 1.7e-117 471472000389 PS00382 Endopeptidase Clp histidine active site. 471472000390 PS00381 Endopeptidase Clp serine active site. 471472000391 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 471472000392 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 471472000393 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 471472000394 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 471472000395 HMMPfam hit to PF05698, Bacterial trigger factor protein (TF) C-ter, score 6.1e-35 471472000396 HMMPfam hit to PF05697, Bacterial trigger factor protein (TF), score 1e-38 471472000397 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 471472000398 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 471472000399 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471472000400 ATP binding site [chemical binding]; other site 471472000401 putative Mg++ binding site [ion binding]; other site 471472000402 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471472000403 nucleotide binding region [chemical binding]; other site 471472000404 ATP-binding site [chemical binding]; other site 471472000405 HMMPfam hit to PF04434, SWIM zinc finger, score 3.8e-07 471472000406 HMMPfam hit to PF04851, Type III restriction enzyme,res subunit, score 1.7e-05 471472000407 HMMPfam hit to PF00176, SNF2 family N-terminal domain, score 5.5e-87 471472000408 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.2e-26 471472000409 cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904 471472000410 MreB and similar proteins; Region: MreB_like; cd10225 471472000411 nucleotide binding site [chemical binding]; other site 471472000412 Mg binding site [ion binding]; other site 471472000413 putative protofilament interaction site [polypeptide binding]; other site 471472000414 RodZ interaction site [polypeptide binding]; other site 471472000415 HMMPfam hit to PF06723, MreB/Mbl protein, score 1.1e-229 471472000416 PS00017 ATP/GTP-binding site motif A (P-loop). 471472000417 HMMPfam hit to PF02491, Cell division protein FtsA,score 0.00014 471472000418 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 471472000419 active site 471472000420 substrate-binding site [chemical binding]; other site 471472000421 metal-binding site [ion binding] 471472000422 GTP binding site [chemical binding]; other site 471472000423 HMMPfam hit to PF00821, Phosphoenolpyruvate carboxykinase, score 0 471472000424 PS00505 Phosphoenolpyruvate carboxykinase (GTP) signature. 471472000425 PS00012 Phosphopantetheine attachment site. 471472000426 Effector from type III secretion system; Region: Effector_1; pfam04518 471472000427 HMMPfam hit to PF04518, Protein of unknown function,DUF582, score 8.8e-200 471472000428 Effector from type III secretion system; Region: Effector_1; pfam04518 471472000429 HMMPfam hit to PF04518, Protein of unknown function,DUF582, score 2.5e-192 471472000430 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 471472000431 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 471472000432 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 471472000433 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 471472000434 HMMPfam hit to PF07479, NAD-dependent glycerol-3-phosphate deh, score 5e-81 471472000435 HMMPfam hit to PF01210, NAD-dependent glycerol-3-phosphate deh, score 1.1e-65 471472000436 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 471472000437 active site 471472000438 HMMPfam hit to PF01704, UTP--glucose-1-phosphate uridylyltransferase, score 8.9e-08 471472000439 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 471472000440 type III secretion system ATPase; Validated; Region: PRK05922 471472000441 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 471472000442 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 471472000443 Walker A motif; other site 471472000444 ATP binding site [chemical binding]; other site 471472000445 Walker B motif; other site 471472000446 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleot, score 5.2e-89 471472000447 PS00152 ATP synthase alpha and beta subunits signature. 471472000448 HMMPfam hit to PF02874, ATP synthase alpha/beta family, beta-ba, score 0.00025 471472000449 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 471472000450 type III secretion system protein; Validated; Region: PRK05934 471472000451 1 probable transmembrane helix predicted for CTL0088 by TMHMM2.0 at aa 247-269 471472000452 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 471472000453 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 471472000454 active site 471472000455 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 471472000456 HMMPfam hit to PF01106, NifU-like domain, score 9.3e-05 471472000457 HMMPfam hit to PF01592, NifU-like N terminal domain,score 1.3e-06 471472000458 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 471472000459 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471472000460 catalytic residue [active] 471472000461 HMMPfam hit to PF00266, Aminotransferase class-V,score 4.5e-07 471472000462 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471472000463 catalytic core [active] 471472000464 HMMPfam hit to PF00300, Phosphoglycerate mutase family, score 1.4e-38 471472000465 PS00175 Phosphoglycerate mutase family phosphohistidine signature. 471472000466 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 471472000467 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471472000468 RNA binding surface [nucleotide binding]; other site 471472000469 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 471472000470 active site 471472000471 PS00430 TonB-dependent receptor proteins signature 1. 471472000472 HMMPfam hit to PF01479, S4 domain, score 2.8e-09 471472000473 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 1e-30 471472000474 PS01149 Rsu family of pseudouridine synthase signature. 471472000475 biotin--protein ligase; Provisional; Region: PRK05935 471472000476 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 471472000477 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase famil, score 2.1e-23 471472000478 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 471472000479 HMMPfam hit to PF01098, Cell cycle protein, score 2.2e-48 471472000480 8 probable transmembrane helices predicted for CTL0095 by TMHMM2.0 at aa 12-29, 77-99, 144-161,166-185,192-214, 279-301, 314-336 and 346-368 471472000481 PS00012 Phosphopantetheine attachment site. 471472000482 PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 471472000483 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 471472000484 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471472000485 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471472000486 motif II; other site 471472000487 7 probable transmembrane helices predicted for CTL0096 by TMHMM2.0 at aa 46-65, 67-86, 106-128,267-289,304-326, 608-627 and 631-653 471472000488 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 3.1e-33 471472000489 PS01229 Hypothetical cof family signature 2. 471472000490 PS00154 E1-E2 ATPases phosphorylation site. 471472000491 HMMPfam hit to PF00122, E1-E2 ATPase, score 1.6e-50 471472000492 CCC1-related protein family; Region: CCC1_like_1; cd02437 471472000493 3 probable transmembrane helices predicted for CTL0097 by TMHMM2.0 at aa 63-85, 181-203 and 223-245 471472000494 seryl-tRNA synthetase; Provisional; Region: PRK05431 471472000495 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 471472000496 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 471472000497 dimer interface [polypeptide binding]; other site 471472000498 active site 471472000499 motif 1; other site 471472000500 motif 2; other site 471472000501 motif 3; other site 471472000502 HMMPfam hit to PF00587, tRNA synthetase class II core domain (G,, score 2.4e-62 471472000503 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 471472000504 HMMPfam hit to PF02403, Seryl-tRNA synthetase N-terminal domain, score 7.6e-33 471472000505 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 471472000506 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 471472000507 catalytic motif [active] 471472000508 Zn binding site [ion binding]; other site 471472000509 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 471472000510 HMMPfam hit to PF00383, Cytidine and deoxycytidylate deaminas, score 2.9e-40 471472000511 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 471472000512 HMMPfam hit to PF01872, RibD C-terminal domain,score 4.4e-95 471472000513 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 471472000514 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 471472000515 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 471472000516 dimerization interface [polypeptide binding]; other site 471472000517 active site 471472000518 PS00430 TonB-dependent receptor proteins signature 1. 471472000519 HMMPfam hit to PF00926, 3,4-dihydroxy-2-butanone 4-phosphate, score 1.6e-97 471472000520 HMMPfam hit to PF00925, GTP cyclohydrolase II,score 6.4e-98 471472000521 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 471472000522 homopentamer interface [polypeptide binding]; other site 471472000523 active site 471472000524 HMMPfam hit to PF00885,6,7-dimethyl-8-ribityllumazine synthase, score 3.4e-40 471472000525 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472000526 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 471472000527 11 probable transmembrane helices predicted for CTL0104 by TMHMM2.0 at aa 10-32, 67-89, 94-116,146-168,183-205, 212-229, 239-261, 300-322, 342-364,385-407 and 412-434 471472000528 HMMPfam hit to PF01235, Sodium:alanine symporter family, score 1.2e-18 471472000529 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 471472000530 substrate binding site [chemical binding]; other site 471472000531 HMMPfam hit to PF01161,Phosphatidylethanolamine-binding protein, score 1.6e-58 471472000532 Proteins containing SET domain [General function prediction only]; Region: COG2940 471472000533 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 471472000534 HMMPfam hit to PF00856, SET domain, score 1.7e-35 471472000535 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 471472000536 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 9.8e-15 471472000537 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 471472000538 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 471472000539 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 471472000540 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 471472000541 HMMPfam hit to PF01580, FtsK/SpoIIIE family, score 1.5e-61 471472000542 PS00017 ATP/GTP-binding site motif A (P-loop). 471472000543 5 probable transmembrane helices predicted for CTL0108 by TMHMM2.0 at aa 17-39, 49-71, 91-113, 128-150 and 159-181 471472000544 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Region: NqrF; COG2871 471472000545 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471472000546 catalytic loop [active] 471472000547 iron binding site [ion binding]; other site 471472000548 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 471472000549 FAD binding pocket [chemical binding]; other site 471472000550 FAD binding motif [chemical binding]; other site 471472000551 phosphate binding motif [ion binding]; other site 471472000552 beta-alpha-beta structure motif; other site 471472000553 NAD binding pocket [chemical binding]; other site 471472000554 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 0.00069 471472000555 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding doma, score 7.4e-12 471472000556 1 probable transmembrane helix predicted for CTL0109 by TMHMM2.0 at aa 7-29 471472000557 preprotein translocase, YajC subunit; Region: yajC; TIGR00739 471472000558 HMMPfam hit to PF02699, Preprotein translocase subunit, score 4e-40 471472000559 2 probable transmembrane helices predicted for CTL0110 by TMHMM2.0 at aa 2-21 and 31-50 471472000560 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472000561 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 471472000562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471472000563 S-adenosylmethionine binding site [chemical binding]; other site 471472000564 HMMPfam hit to PF05958, tRNA (Uracil-5-)-methyltransferase, score 2.8e-08 471472000565 PS01231 RNA methyltransferase trmA family signature 2. 471472000566 PS01230 RNA methyltransferase trmA family signature 1. 471472000567 Histone H1-like protein Hc1; Region: Hc1; pfam07432 471472000568 HMMPfam hit to PF07432, Histone H1-like protein Hc1,score 4.7e-78 471472000569 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471472000570 binding surface 471472000571 TPR motif; other site 471472000572 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471472000573 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 471472000574 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471472000575 HMMPfam hit to PF01593, Flavin containing amine oxidoreductase, score 0.00038 471472000576 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.0012 471472000577 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 471472000578 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 471472000579 HemN C-terminal domain; Region: HemN_C; pfam06969 471472000580 HMMPfam hit to PF06969, HemN C-terminal region,score 1.9e-46 471472000581 HMMPfam hit to PF04055, Radical SAM superfamily,score 2e-21 471472000582 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 471472000583 substrate binding site [chemical binding]; other site 471472000584 active site 471472000585 HMMPfam hit to PF01208, Uroporphyrinogen decarboxylase (URO-D), score 1.6e-46 471472000586 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 471472000587 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 471472000588 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 471472000589 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471472000590 ATP binding site [chemical binding]; other site 471472000591 putative Mg++ binding site [ion binding]; other site 471472000592 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471472000593 nucleotide binding region [chemical binding]; other site 471472000594 ATP-binding site [chemical binding]; other site 471472000595 TRCF domain; Region: TRCF; pfam03461 471472000596 HMMPfam hit to PF03461, TRCF domain, score 4.3e-43 471472000597 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 4.7e-17 471472000598 HMMPfam hit to PF00270, DEAD/DEAH box helicase,score 1e-32 471472000599 PS00017 ATP/GTP-binding site motif A (P-loop). 471472000600 HMMPfam hit to PF02559, CarD-like/TRCF domain,score 3e-35 471472000601 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 471472000602 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 471472000603 motif 1; other site 471472000604 active site 471472000605 motif 2; other site 471472000606 motif 3; other site 471472000607 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 471472000608 DHHA1 domain; Region: DHHA1; pfam02272 471472000609 HMMPfam hit to PF02272, DHHA1 domain, score 1.4e-12 471472000610 HMMPfam hit to PF07973, Threonyl and Alanyl tRNA synthetase seco, score 6.5e-17 471472000611 HMMPfam hit to PF01411, tRNA synthetases class II (A), score 0 471472000612 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 471472000613 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 471472000614 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 471472000615 TPP-binding site [chemical binding]; other site 471472000616 dimer interface [polypeptide binding]; other site 471472000617 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471472000618 PYR/PP interface [polypeptide binding]; other site 471472000619 dimer interface [polypeptide binding]; other site 471472000620 TPP binding site [chemical binding]; other site 471472000621 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471472000622 HMMPfam hit to PF00456, Transketolase, thiamine diphosphate b, score 1.3e-154 471472000623 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 1.9e-64 471472000624 PS00213 Lipocalin signature. 471472000625 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 0.0009 471472000626 AMP nucleosidase, putative; Region: AMN-like; TIGR01721 471472000627 HMMPfam hit to PF01048, Phosphorylase family, score 7.4e-08 471472000628 elongation factor P; Validated; Region: PRK00529 471472000629 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 471472000630 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 471472000631 RNA binding site [nucleotide binding]; other site 471472000632 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 471472000633 RNA binding site [nucleotide binding]; other site 471472000634 HMMPfam hit to PF08207, Elongation factor P (EF-P) KOW-like domain, score 1.2e-18 471472000635 HMMPfam hit to PF01132, Elongation factor P (EF-P) OB domain, score 3.8e-05 471472000636 PS01275 Elongation factor P signature. 471472000637 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 471472000638 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471472000639 active site 471472000640 metal binding site [ion binding]; metal-binding site 471472000641 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471472000642 active site 471472000643 metal binding site [ion binding]; metal-binding site 471472000644 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 7.8e-17 471472000645 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 471472000646 HMMPfam hit to PF00118, TCP-1/cpn60 chaperonin family, score 1.5e-21 471472000647 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471472000648 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 471472000649 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471472000650 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471472000651 HMMPfam hit to PF01225, Mur ligase family,catalytic domain, score 5.5e-16 471472000652 HMMPfam hit to PF08245, Mur ligase middle domain,score 8.6e-17 471472000653 HMMPfam hit to PF02875, Mur ligase family,glutamate ligase doma, score 6.9e-09 471472000654 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 471472000655 Mg++ binding site [ion binding]; other site 471472000656 putative catalytic motif [active] 471472000657 putative substrate binding site [chemical binding]; other site 471472000658 10 probable transmembrane helices predicted for CTL0126 by TMHMM2.0 at aa 10-29, 54-76, 80-99,119-137,157-179, 184-206, 210-232, 239-261, 265-287 and 313-335 471472000659 HMMPfam hit to PF00953, Glycosyl transferase family,score 3.2e-40 471472000660 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683 471472000661 TrkA-N domain; Region: TrkA_N; pfam02254 471472000662 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471472000663 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471472000664 HMMPfam hit to PF08245, Mur ligase middle domain,score 3e-23 471472000665 HMMPfam hit to PF02875, Mur ligase family,glutamate ligase doma, score 1.2e-12 471472000666 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471472000667 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471472000668 1 probable transmembrane helix predicted for CTL0128 by TMHMM2.0 at aa 7-25 471472000669 HMMPfam hit to PF01476, LysM domain, score 1e-16 471472000670 HMMPfam hit to PF01476, LysM domain, score 3.2e-13 471472000671 cell division protein FtsW; Region: ftsW; TIGR02614 471472000672 HMMPfam hit to PF01098, Cell cycle protein, score 8e-79 471472000673 9 probable transmembrane helices predicted for CTL0129 by TMHMM2.0 at aa 4-21, 41-63, 73-92,137-154,159-176, 181-203, 267-289, 296-318 and 333-355 471472000674 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 471472000675 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 471472000676 active site 471472000677 homodimer interface [polypeptide binding]; other site 471472000678 HMMPfam hit to PF03033, Glycosyltransferase family,score 2.3e-42 471472000679 1 probable transmembrane helix predicted for CTL0130 by TMHMM2.0 at aa 7-29 471472000680 HMMPfam hit to PF04101, Glycosyltransferase family,score 4.3e-54 471472000681 bifunctional D-alanyl-alanine synthetase A/UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: PRK14573 471472000682 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471472000683 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471472000684 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471472000685 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 471472000686 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 471472000687 1 probable transmembrane helix predicted for CTL0131 by TMHMM2.0 at aa 5-24 471472000688 HMMPfam hit to PF01225, Mur ligase family,catalytic domain, score 7.5e-34 471472000689 HMMPfam hit to PF08245, Mur ligase middle domain,score 5.8e-15 471472000690 HMMPfam hit to PF02875, Mur ligase family,glutamate ligase d, score 3.6e-26 471472000691 HMMPfam hit to PF01820, D-ala D-ala ligase N-terminus, score 1.3e-61 471472000692 PS00017 ATP/GTP-binding site motif A (P-loop). 471472000693 PS00843 D-alanine--D-alanine ligase signature 1. 471472000694 HMMPfam hit to PF07478, D-ala D-ala ligase C-terminus, score 1.3e-113 471472000695 HMMPfam hit to PF02222, ATP-grasp domain, score 0.0014 471472000696 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cd02409 471472000697 G-X-X-G motif; other site 471472000698 PS00079 Multicopper oxidases signature 1. 471472000699 1 probable transmembrane helix predicted for CTL0133 by TMHMM2.0 at aa 26-48 471472000700 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471472000701 anti sigma factor interaction site; other site 471472000702 regulatory phosphorylation site [posttranslational modification]; other site 471472000703 HMMPfam hit to PF01740, STAS domain, score 7.2e-28 471472000704 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 471472000705 PS00017 ATP/GTP-binding site motif A (P-loop). 471472000706 HMMPfam hit to PF01715, IPP transferase, score 2.7e-72 471472000707 hypothetical protein; Provisional; Region: PRK05927 471472000708 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 471472000709 HMMPfam hit to PF04055, Radical SAM superfamily,score 7.7e-20 471472000710 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 471472000711 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 471472000712 HMMPfam hit to PF02410, Domain of unknown function DUF143, score 6.6e-55 471472000713 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 471472000714 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 471472000715 dimer interface [polypeptide binding]; other site 471472000716 active site 471472000717 HMMPfam hit to PF00109, Beta-ketoacyl synthase,N-terminal do, score 8.7e-87 471472000718 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472000719 PS00205 Transferrins signature 1. 471472000720 PS00606 Beta-ketoacyl synthases active site. 471472000721 HMMPfam hit to PF02801, Beta-ketoacyl synthase,C-terminal do, score 2.7e-64 471472000722 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 471472000723 nudix motif; other site 471472000724 HMMPfam hit to PF00293, NUDIX domain, score 6.9e-25 471472000725 PS00893 mutT domain signature. 471472000726 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 471472000727 dimer interface [polypeptide binding]; other site 471472000728 substrate binding site [chemical binding]; other site 471472000729 metal binding sites [ion binding]; metal-binding site 471472000730 HMMPfam hit to PF00719, Inorganic pyrophosphatase,score 5.8e-16 471472000731 PS00387 Inorganic pyrophosphatase signature. 471472000732 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 471472000733 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 471472000734 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 471472000735 NAD binding site [chemical binding]; other site 471472000736 Phe binding site; other site 471472000737 HMMPfam hit to PF02812, Glu/Leu/Phe/Val dehydrogenase, dimeri, score 5.1e-18 471472000738 PS01109 Ribosomal protein L10 signature. 471472000739 HMMPfam hit to PF00208,Glutamate/Leucine/Phenylalanine/Valin, score 3e-23 471472000740 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 471472000741 active site 471472000742 putative lithium-binding site [ion binding]; other site 471472000743 substrate binding site [chemical binding]; other site 471472000744 HMMPfam hit to PF00459, Inositol monophosphatase family, score 2.1e-66 471472000745 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471472000746 putative acyl-acceptor binding pocket; other site 471472000747 HMMPfam hit to PF01553, Acyltransferase, score 0.00014 471472000748 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 471472000749 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471472000750 acyl-activating enzyme (AAE) consensus motif; other site 471472000751 AMP binding site [chemical binding]; other site 471472000752 active site 471472000753 CoA binding site [chemical binding]; other site 471472000754 HMMPfam hit to PF00501, AMP-binding enzyme, score 1.3e-87 471472000755 1 probable transmembrane helix predicted for CTL0145 by TMHMM2.0 at aa 69-91 471472000756 8-amino-7-oxononanoate synthase; Provisional; Region: PRK05937 471472000757 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 471472000758 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471472000759 catalytic residue [active] 471472000760 HMMPfam hit to PF00155, Aminotransferase class I and II, score 1.3e-15 471472000761 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 471472000762 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 471472000763 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 471472000764 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471472000765 ATP binding site [chemical binding]; other site 471472000766 putative Mg++ binding site [ion binding]; other site 471472000767 helicase superfamily c-terminal domain; Region: HELICc; smart00490 471472000768 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 0.0083 471472000769 HMMPfam hit to PF00270, DEAD/DEAH box helicase,score 5.1e-08 471472000770 HMMPfam hit to PF04851, Type III restriction enzyme,res subunit, score 1e-07 471472000771 PS00017 ATP/GTP-binding site motif A (P-loop). 471472000772 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 471472000773 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472000774 1 probable transmembrane helix predicted for CTL0149 by TMHMM2.0 at aa 4-23 471472000775 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 471472000776 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 471472000777 dimer interface [polypeptide binding]; other site 471472000778 putative anticodon binding site; other site 471472000779 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471472000780 motif 1; other site 471472000781 dimer interface [polypeptide binding]; other site 471472000782 active site 471472000783 motif 2; other site 471472000784 motif 3; other site 471472000785 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 1.3e-12 471472000786 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 4.5e-128 471472000787 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 471472000788 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 471472000789 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 471472000790 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 471472000791 active site 471472000792 HIGH motif; other site 471472000793 KMSKS motif; other site 471472000794 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471472000795 tRNA binding surface [nucleotide binding]; other site 471472000796 anticodon binding site; other site 471472000797 HMMPfam hit to PF01406, tRNA synthetases class I (C) catalytic d, score 1.7e-135 471472000798 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 471472000799 ribonuclease P; Reviewed; Region: rnpA; PRK00730 471472000800 HMMPfam hit to PF00825, Ribonuclease P, score 3.3e-14 471472000801 PS00648 Bacterial ribonuclease P protein component signature. 471472000802 Ribosomal protein L34 [Translation, ribosomal structure and biogenesis]; Region: RpmH; COG0230 471472000803 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 471472000804 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 471472000805 HMMPfam hit to PF00253, Ribosomal protein S14p/S29e,score 7.6e-23 471472000806 PS00527 Ribosomal protein S14 signature. 471472000807 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 471472000808 2 probable transmembrane helices predicted for CTL0156 by TMHMM2.0 at aa 5-24 and 31-53 471472000809 PS00636 Nt-dnaJ domain signature. 471472000810 3 probable transmembrane helices predicted for CTL0157 by TMHMM2.0 at aa 12-29, 33-50 and 57-79 471472000811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 471472000812 HMMPfam hit to PF03780, Protein of unknown function (DUF322), score 6.5e-43 471472000813 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 471472000814 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 471472000815 active site 471472000816 catalytic site [active] 471472000817 putative DNA binding site [nucleotide binding]; other site 471472000818 GIY-YIG motif/motif A; other site 471472000819 metal binding site [ion binding]; metal-binding site 471472000820 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 471472000821 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 471472000822 HMMPfam hit to PF08459, UvrC Helix-hairpin-helix N-terminal, score 7.1e-73 471472000823 HMMPfam hit to PF01541, GIY-YIG catalytic domain,score 1.2e-22 471472000824 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 471472000825 MutS domain I; Region: MutS_I; pfam01624 471472000826 MutS domain II; Region: MutS_II; pfam05188 471472000827 MutS domain III; Region: MutS_III; pfam05192 471472000828 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 471472000829 Walker A/P-loop; other site 471472000830 ATP binding site [chemical binding]; other site 471472000831 Q-loop/lid; other site 471472000832 ABC transporter signature motif; other site 471472000833 Walker B; other site 471472000834 D-loop; other site 471472000835 H-loop/switch region; other site 471472000836 HMMPfam hit to PF00488, MutS domain V, score 5.9e-161 471472000837 PS00486 DNA mismatch repair proteins mutS family signature. 471472000838 PS00017 ATP/GTP-binding site motif A (P-loop). 471472000839 HMMPfam hit to PF05192, MutS domain III, score 4.7e-74 471472000840 HMMPfam hit to PF05190, MutS family domain IV,score 9.7e-36 471472000841 HMMPfam hit to PF05188, MutS domain II, score 1.7e-38 471472000842 HMMPfam hit to PF01624, MutS domain I, score 1.9e-56 471472000843 conserved hypothetical protein (pseudogene) 471472000844 DNA primase; Validated; Region: dnaG; PRK05667 471472000845 CHC2 zinc finger; Region: zf-CHC2; pfam01807 471472000846 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 471472000847 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 471472000848 active site 471472000849 metal binding site [ion binding]; metal-binding site 471472000850 interdomain interaction site; other site 471472000851 HMMPfam hit to PF01807, CHC2 zinc finger, score 3.8e-62 471472000852 HMMPfam hit to PF08275, DNA primase catalytic core,N-terminal domai, score 5.8e-51 471472000853 HMMPfam hit to PF01751, Toprim domain, score 7.4e-17 471472000854 1 probable transmembrane helix predicted for CTL0163 by TMHMM2.0 at aa 7-26 471472000855 glycyl-tRNA synthetase; Provisional; Region: PRK14908 471472000856 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 471472000857 dimer interface [polypeptide binding]; other site 471472000858 motif 1; other site 471472000859 active site 471472000860 motif 2; other site 471472000861 motif 3; other site 471472000862 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 471472000863 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471472000864 HMMPfam hit to PF05746, DALR anticodon binding domain, score 0.0021 471472000865 HMMPfam hit to PF02092, Glycyl-tRNA synthetase beta subunit, score 0 471472000866 HMMPfam hit to PF02091, Glycyl-tRNA synthetase alpha subunit, score 2.3e-235 471472000867 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 471472000868 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 471472000869 5 probable transmembrane helices predicted for CTL0166 by TMHMM2.0 at aa 5-24, 29-51, 82-104, 134-156 and 163-185 471472000870 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 1.4e-32 471472000871 PS00379 CDP-alcohol phosphatidyltransferases signature. 471472000872 glycogen synthase; Provisional; Region: glgA; PRK00654 471472000873 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 471472000874 ADP-binding pocket [chemical binding]; other site 471472000875 homodimer interface [polypeptide binding]; other site 471472000876 HMMPfam hit to PF00534, Glycosyl transferases group,score 0.00047 471472000877 HMMPfam hit to PF08323, Starch synthase catalytic domain, score 1.5e-82 471472000878 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 471472000879 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 471472000880 5S rRNA interface [nucleotide binding]; other site 471472000881 CTC domain interface [polypeptide binding]; other site 471472000882 L16 interface [polypeptide binding]; other site 471472000883 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 471472000884 HMMPfam hit to PF01386, Ribosomal L25p family,score 6.7e-09 471472000885 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 471472000886 putative active site [active] 471472000887 catalytic residue [active] 471472000888 HMMPfam hit to PF01195, Peptidyl-tRNA hydrolase,score 5.9e-48 471472000889 PS01195 Peptidyl-tRNA hydrolase signature 1. 471472000890 PS01196 Peptidyl-tRNA hydrolase signature 2. 471472000891 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 471472000892 HMMPfam hit to PF01250, Ribosomal protein S6, score 4.7e-17 471472000893 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 471472000894 HMMPfam hit to PF01084, Ribosomal protein S18,score 2.1e-32 471472000895 PS00057 Ribosomal protein S18 signature. 471472000896 Ribosomal protein L9 [Translation, ribosomal structure and biogenesis]; Region: RplI; COG0359 471472000897 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 471472000898 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 471472000899 HMMPfam hit to PF01281, Ribosomal protein L9,N-terminal domai, score 4.3e-15 471472000900 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK00650 471472000901 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 471472000902 HMMPfam hit to PF00288, GHMP kinases N terminal domain, score 2.6e-14 471472000903 HMMPfam hit to PF08544, GHMP kinases C terminal,score 3.3e-05 471472000904 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 471472000905 HMMPfam hit to PF07399, Protein of unknown function (DUF1504), score 0 471472000906 11 probable transmembrane helices predicted for CTL0174 by TMHMM2.0 at aa 10-32, 61-83, 98-116,136-153,180-202, 223-242, 267-298, 311-330, 345-367,379-401 and 416-438 471472000907 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 471472000908 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471472000909 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471472000910 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471472000911 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 1.2e-18 471472000912 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 1.6e-25 471472000913 HMMPfam hit to PF00675, Insulinase (Peptidase family M16), score 5.9e-26 471472000914 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472000915 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 471472000916 putative acyl-acceptor binding pocket; other site 471472000917 HMMPfam hit to PF01553, Acyltransferase, score 1.2e-38 471472000918 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 471472000919 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 471472000920 homodimer interface [polypeptide binding]; other site 471472000921 oligonucleotide binding site [chemical binding]; other site 471472000922 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 471472000923 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 471472000924 HMMPfam hit to PF01783, Ribosomal L32p protein family, score 2.4e-23 471472000925 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 471472000926 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13846 471472000927 HMMPfam hit to PF02504, Fatty acid synthesis protein, score 8.7e-176 471472000928 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 471472000929 Autotransporter beta-domain; Region: Autotransporter; pfam03797 471472000930 PS00430 TonB-dependent receptor proteins signature 1. 471472000931 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472000932 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 8.5 471472000933 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 12 471472000934 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 1.9 471472000935 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 5.7 471472000936 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.08 471472000937 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 6.2 471472000938 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 33 471472000939 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 11 471472000940 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 4.2 471472000941 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 2 471472000942 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 5.7 471472000943 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.79 471472000944 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 9.8 471472000945 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.2 471472000946 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.0034 471472000947 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 2.8 471472000948 HMMPfam hit to PF07548, Chlamydia polymorphic membrane protei, score 1.2e-55 471472000949 HMMPfam hit to PF03797, Autotransporter beta-domain,score 1.2e-39 471472000950 IncA protein; Region: IncA; pfam04156 471472000951 Protein of unknown function (DUF972); Region: DUF972; pfam06156 471472000952 HMMPfam hit to PF04156, IncA protein, score 5.2e-43 471472000953 2 probable transmembrane helices predicted for CTL0184 by TMHMM2.0 at aa 40-62 and 72-94 471472000954 YtxH-like protein; Region: YtxH; pfam12732 471472000955 1 probable transmembrane helix predicted for CTL0185 by TMHMM2.0 at aa 47-69 471472000956 1 probable transmembrane helix predicted for CTL0186 by TMHMM2.0 at aa 10-32 471472000957 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 471472000958 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 471472000959 active site 471472000960 substrate binding site [chemical binding]; other site 471472000961 metal binding site [ion binding]; metal-binding site 471472000962 HMMPfam hit to PF02878,Phosphoglucomutase/phosphomannomutase, al, score 2.9e-63 471472000963 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 471472000964 HMMPfam hit to PF02879,Phosphoglucomutase/phosphomannomutase, al, score 8.1e-35 471472000965 HMMPfam hit to PF02880,Phosphoglucomutase/phosphomannomutase, al, score 1.3e-24 471472000966 HMMPfam hit to PF00408,Phosphoglucomutase/phosphomannomutase, C-, score 8.3e-05 471472000967 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 471472000968 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 471472000969 glutaminase active site [active] 471472000970 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 471472000971 dimer interface [polypeptide binding]; other site 471472000972 active site 471472000973 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 471472000974 dimer interface [polypeptide binding]; other site 471472000975 active site 471472000976 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 2.1e-33 471472000977 PS00211 ABC transporters family signature. 471472000978 PS00017 ATP/GTP-binding site motif A (P-loop). 471472000979 HMMPfam hit to PF01380, SIS domain, score 2.7e-30 471472000980 HMMPfam hit to PF01380, SIS domain, score 1.1e-14 471472000981 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 471472000982 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 471472000983 HMMPfam hit to PF03222, Tryptophan/tyrosine permease family, score 5.6e-219 471472000984 11 probable transmembrane helices predicted for CTL0189 by TMHMM2.0 at aa 7-29, 39-61, 82-101,121-138,151-170, 185-207, 219-241, 268-290, 311-330,340-357 and 370-392 471472000985 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 471472000986 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 471472000987 HMMPfam hit to PF03222, Tryptophan/tyrosine permease family, score 4.1e-210 471472000988 11 probable transmembrane helices predicted for CTL0190 by TMHMM2.0 at aa 7-29, 39-61, 82-104,124-146,153-175, 190-209, 221-243, 272-294, 311-328,338-357 and 378-396 471472000989 motif repeated in this and the adjacent CDS gene product 471472000990 motif repeated in this and the adjacent CDS gene product 471472000991 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 471472000992 HMMPfam hit to PF01027, Uncharacterised protein family UPF0005, score 2.4e-06 471472000993 7 probable transmembrane helices predicted for CTL0191 by TMHMM2.0 at aa 21-43, 48-67, 74-96,106-128,141-163, 167-186 and 206-228 471472000994 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 471472000995 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 471472000996 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 471472000997 HMMPfam hit to PF00448, SRP54-type protein, GTPase domain, score 1.2e-109 471472000998 PS00017 ATP/GTP-binding site motif A (P-loop). 471472000999 succinyl-CoA synthetase, beta subunit; Region: sucCoAbeta; TIGR01016 471472001000 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 471472001001 CoA-ligase; Region: Ligase_CoA; pfam00549 471472001002 HMMPfam hit to PF08442, ATP-grasp domain, score 1.9e-82 471472001003 HMMPfam hit to PF01071, Phosphoribosylglycinamide synthetase, ATP, score 0.0025 471472001004 HMMPfam hit to PF00549, CoA-ligase, score 5.2e-41 471472001005 2 probable transmembrane helices predicted for CTL0193 by TMHMM2.0 at aa 248-270 and 313-335 471472001006 PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3. 471472001007 succinyl-CoA synthetase, alpha subunit; Region: sucCoAalpha; TIGR01019 471472001008 CoA binding domain; Region: CoA_binding; pfam02629 471472001009 CoA-ligase; Region: Ligase_CoA; pfam00549 471472001010 HMMPfam hit to PF02629, CoA binding domain, score 9.2e-44 471472001011 HMMPfam hit to PF00549, CoA-ligase, score 2.4e-57 471472001012 PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1. 471472001013 PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site. 471472001014 PS00017 ATP/GTP-binding site motif A (P-loop). 471472001015 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 471472001016 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 471472001017 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471472001018 protein binding site [polypeptide binding]; other site 471472001019 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471472001020 protein binding site [polypeptide binding]; other site 471472001021 HMMPfam hit to PF00089, Trypsin, score 2e-18 471472001022 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 1.5e-12 471472001023 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 0.0014 471472001024 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 471472001025 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471472001026 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471472001027 Peptidase M16C associated; Region: M16C_assoc; pfam08367 471472001028 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471472001029 HMMPfam hit to PF00675, Insulinase (Peptidase family M16), score 0.019 471472001030 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 1e-27 471472001031 HMMPfam hit to PF08367, Peptidase M16C associated,score 4e-118 471472001032 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 2.1e-24 471472001033 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 471472001034 RmuC family; Region: RmuC; pfam02646 471472001035 HMMPfam hit to PF02646, RmuC family, score 6.2e-140 471472001036 1 probable transmembrane helix predicted for CTL0197 by TMHMM2.0 at aa 13-35 471472001037 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 471472001038 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471472001039 7 probable transmembrane helices predicted for CTL0198 by TMHMM2.0 at aa 15-37, 79-101, 111-133,145-167,182-204, 211-230 and 235-257 471472001040 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 4.7e-22 471472001041 PS00379 CDP-alcohol phosphatidyltransferases signature. 471472001042 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365 471472001043 ATP cone domain; Region: ATP-cone; pfam03477 471472001044 ATP cone domain; Region: ATP-cone; pfam03477 471472001045 Class I ribonucleotide reductase; Region: RNR_I; cd01679 471472001046 active site 471472001047 dimer interface [polypeptide binding]; other site 471472001048 catalytic residues [active] 471472001049 effector binding site; other site 471472001050 R2 peptide binding site; other site 471472001051 HMMPfam hit to PF03477, ATP cone domain, score 7.1e-32 471472001052 HMMPfam hit to PF03477, ATP cone domain, score 1.6e-33 471472001053 HMMPfam hit to PF03477, ATP cone domain, score 2e-08 471472001054 HMMPfam hit to PF00317, Ribonucleotide reductase,all-alpha d, score 4.4e-30 471472001055 PS00185 Isopenicillin N synthetase signature 1. 471472001056 HMMPfam hit to PF02867, Ribonucleotide reductase,barrel doma, score 1.1e-183 471472001057 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 471472001058 dimer interface [polypeptide binding]; other site 471472001059 putative radical transfer pathway; other site 471472001060 diiron center [ion binding]; other site 471472001061 tyrosyl radical; other site 471472001062 HMMPfam hit to PF00268, Ribonucleotide reductase,small chain, score 7e-35 471472001063 1 probable transmembrane helix predicted for CTL0200 by TMHMM2.0 at aa 185-207 471472001064 Putative methyltransferase; Region: Methyltransf_4; pfam02390 471472001065 HMMPfam hit to PF02390, Putative methyltransferase,score 2.2e-81 471472001066 Methyltransferase domain; Region: Methyltransf_18; pfam12847 471472001067 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 471472001068 HMMPfam hit to PF06962, Putative rRNA methylase,score 3.3e-75 471472001069 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 471472001070 FAD binding domain; Region: FAD_binding_4; cl19922 471472001071 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 471472001072 HMMPfam hit to PF02873,UDP-N-acetylenolpyruvoylglucosamine red, score 3.4e-58 471472001073 HMMPfam hit to PF01565, FAD binding domain, score 5.4e-13 471472001074 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 471472001075 putative RNA binding site [nucleotide binding]; other site 471472001076 HMMPfam hit to PF01029, NusB family, score 3e-39 471472001077 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 471472001078 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 471472001079 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 471472001080 HMMPfam hit to PF05198, Translation initiation factor IF-3, N-termin, score 5.2e-48 471472001081 PS00938 Initiation factor 3 signature. 471472001082 HMMPfam hit to PF00707, Translation initiation factor IF-3, C-termin, score 2.1e-51 471472001083 Ribosomal protein L35 [Translation, ribosomal structure and biogenesis]; Region: RpmI; COG0291 471472001084 HMMPfam hit to PF01632, Ribosomal protein L35,score 2.6e-11 471472001085 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 471472001086 23S rRNA binding site [nucleotide binding]; other site 471472001087 L21 binding site [polypeptide binding]; other site 471472001088 L13 binding site [polypeptide binding]; other site 471472001089 HMMPfam hit to PF00453, Ribosomal protein L20,score 2.4e-32 471472001090 PS00937 Ribosomal protein L20 signature. 471472001091 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 471472001092 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 471472001093 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 471472001094 dimer interface [polypeptide binding]; other site 471472001095 motif 1; other site 471472001096 active site 471472001097 motif 2; other site 471472001098 motif 3; other site 471472001099 HMMPfam hit to PF02912, Aminoacyl tRNA synthetase class II, N, score 8e-26 471472001100 HMMPfam hit to PF01409, tRNA synthetases class II core domain, score 1.4e-145 471472001101 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 471472001102 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 471472001103 Predicted permeases [General function prediction only]; Region: COG0795 471472001104 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ family, score 2.2e-70 471472001105 4 probable transmembrane helices predicted for CTL0210 by TMHMM2.0 at aa 7-29, 279-301, 313-335 and 340-362 471472001106 Predicted permeases [General function prediction only]; Region: COG0795 471472001107 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ family, score 7e-79 471472001108 6 probable transmembrane helices predicted for CTL0211 by TMHMM2.0 at aa 17-39, 54-76, 97-116,274-293,300-317 and 322-344 471472001109 PS00017 ATP/GTP-binding site motif A (P-loop). 471472001110 PS00017 ATP/GTP-binding site motif A (P-loop). 471472001111 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 471472001112 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 471472001113 Ligand Binding Site [chemical binding]; other site 471472001114 HMMPfam hit to PF01171, PP-loop family, score 2e-69 471472001115 HMMPfam hit to PF06508, ExsB, score 0.0036 471472001116 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 471472001117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471472001118 Walker A motif; other site 471472001119 ATP binding site [chemical binding]; other site 471472001120 Walker B motif; other site 471472001121 arginine finger; other site 471472001122 Peptidase family M41; Region: Peptidase_M41; pfam01434 471472001123 2 probable transmembrane helices predicted for CTL0213 by TMHMM2.0 at aa 15-37 and 372-394 471472001124 HMMPfam hit to PF06480, FtsH Extracellular, score 1.8e-36 471472001125 HMMPfam hit to PF00004, ATPase family associated with various c, score 1.3e-91 471472001126 HMMPfam hit to PF07728, ATPase family associated with various c, score 0.00022 471472001127 PS00017 ATP/GTP-binding site motif A (P-loop). 471472001128 PS00674 AAA-protein family signature. 471472001129 HMMPfam hit to PF01434, Peptidase family M41, score 4.3e-121 471472001130 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 471472001131 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 471472001132 RNase E interface [polypeptide binding]; other site 471472001133 trimer interface [polypeptide binding]; other site 471472001134 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 471472001135 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 471472001136 RNase E interface [polypeptide binding]; other site 471472001137 trimer interface [polypeptide binding]; other site 471472001138 active site 471472001139 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 471472001140 putative nucleic acid binding region [nucleotide binding]; other site 471472001141 G-X-X-G motif; other site 471472001142 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 471472001143 RNA binding site [nucleotide binding]; other site 471472001144 domain interface; other site 471472001145 HMMPfam hit to PF00575, S1 RNA binding domain,score 3.3e-16 471472001146 HMMPfam hit to PF00013, KH domain, score 5.7e-16 471472001147 HMMPfam hit to PF03725, 3' exoribonuclease family,domain, score 5.7e-23 471472001148 HMMPfam hit to PF01138, 3' exoribonuclease family,domain, score 1.3e-46 471472001149 HMMPfam hit to PF03726, Polyribonucleotide nucleotidyltransferase,, score 0.00014 471472001150 HMMPfam hit to PF03725, 3' exoribonuclease family,domain, score 1.1e-14 471472001151 HMMPfam hit to PF01138, 3' exoribonuclease family,domain, score 8.9e-28 471472001152 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 471472001153 16S/18S rRNA binding site [nucleotide binding]; other site 471472001154 S13e-L30e interaction site [polypeptide binding]; other site 471472001155 25S rRNA binding site [nucleotide binding]; other site 471472001156 HMMPfam hit to PF00312, Ribosomal protein S15,score 7.6e-27 471472001157 PS00362 Ribosomal protein S15 signature. 471472001158 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 471472001159 nucleoside/Zn binding site; other site 471472001160 dimer interface [polypeptide binding]; other site 471472001161 catalytic motif [active] 471472001162 HMMPfam hit to PF00383, Cytidine and deoxycytidylate deaminas, score 1.8e-45 471472001163 4 probable transmembrane helices predicted for CTL0218 by TMHMM2.0 at aa 22-44, 120-142, 147-165 and 185-207 471472001164 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472001165 Protein of unknown function (DUF720); Region: DUF720; pfam05302 471472001166 HMMPfam hit to PF05302, Protein of unknown function (DUF720), score 1.7e-90 471472001167 Protein of unknown function (DUF720); Region: DUF720; pfam05302 471472001168 HMMPfam hit to PF05302, Protein of unknown function (DUF720), score 3.3e-82 471472001169 Protein of unknown function (DUF720); Region: DUF720; pfam05302 471472001170 HMMPfam hit to PF05302, Protein of unknown function (DUF720), score 5.2e-76 471472001171 Domain of unknown function (DUF334); Region: DUF334; pfam03904 471472001172 Geminin; Region: Geminin; pfam07412 471472001173 4 probable transmembrane helices predicted for CTL0223 by TMHMM2.0 at aa 15-37, 44-66, 71-88 and 95-117 471472001174 methionine aminopeptidase; Provisional; Region: PRK12318 471472001175 SEC-C motif; Region: SEC-C; pfam02810 471472001176 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471472001177 active site 471472001178 HMMPfam hit to PF00557, metallopeptidase family M24,score 4.8e-54 471472001179 PS00215 Mitochondrial energy transfer proteins signature. 471472001180 HMMPfam hit to PF02810, SEC-C motif, score 5e-10 471472001181 MarC family integral membrane protein; Region: MarC; pfam01914 471472001182 HMMPfam hit to PF01914, MarC family integral membrane protein, score 2.3e-82 471472001183 6 probable transmembrane helices predicted for CTL0225 by TMHMM2.0 at aa 10-29, 41-63, 67-86,107-129,139-161 and 174-196 471472001184 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 471472001185 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 471472001186 HMMPfam hit to PF01914, MarC family integral membrane protein, score 0.00012 471472001187 5 probable transmembrane helices predicted for CTL0226 by TMHMM2.0 at aa 47-66, 73-92, 112-134, 139-161 and 171-193 471472001188 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 471472001189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471472001190 dimer interface [polypeptide binding]; other site 471472001191 conserved gate region; other site 471472001192 putative PBP binding loops; other site 471472001193 ABC-ATPase subunit interface; other site 471472001194 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 471472001195 NMT1/THI5 like; Region: NMT1; pfam09084 471472001196 6 probable transmembrane helices predicted for CTL0227 by TMHMM2.0 at aa 4-21, 59-81, 91-113,172-194,214-236 and 257-274 471472001197 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.6e-31 471472001198 fumarate hydratase (pseudogene) 471472001199 HMMPfam hit to PF00206, Lyase, score 3.7e-132 471472001200 high affinity sulphate transporter 1; Region: sulP; TIGR00815 471472001201 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 471472001202 Sulfate transporter family; Region: Sulfate_transp; pfam00916 471472001203 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 471472001204 HMMPfam hit to PF01740, STAS domain, score 4.7e-19 471472001205 HMMPfam hit to PF00916, Sulfate transporter family,score 3.5e-57 471472001206 HMMPfam hit to PF00860, Permease family, score 0.0087 471472001207 10 probable transmembrane helices predicted for CTL0231 by TMHMM2.0 at aa 33-55, 60-82, 105-127,134-151,177-199, 206-223, 257-279, 325-347, 357-379 and 386-408 471472001208 Na+/H+ antiporter, NhaD family; Region: NhaD; TIGR00775 471472001209 11 probable transmembrane helices predicted for CTL0232 by TMHMM2.0 at aa 7-25, 30-49, 61-78,98-127,139-158, 173-195, 240-259, 279-301, 322-344, 359-381 and 394-413 471472001210 HMMPfam hit to PF03600, Citrate transporter, score 0.00094 471472001211 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 471472001212 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 471472001213 active site triad [active] 471472001214 HMMPfam hit to PF03572, Peptidase family S41, score 6.1e-44 471472001215 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 471472001216 Fe-S cluster binding site [ion binding]; other site 471472001217 substrate binding site [chemical binding]; other site 471472001218 catalytic site [active] 471472001219 HMMPfam hit to PF02401, LytB protein, score 2.9e-183 471472001220 ATP synthase I chain; Region: ATP_synt_I; pfam03899 471472001221 4 probable transmembrane helices predicted for CTL0236 by TMHMM2.0 at aa 316-338, 342-364, 385-407 and 422-441 471472001222 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 471472001223 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471472001224 binding surface 471472001225 TPR motif; other site 471472001226 HMMPfam hit to PF07720, Tetratricopeptide repeat,score 1.5e-08 471472001227 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 471472001228 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471472001229 active site 471472001230 DNA binding site [nucleotide binding] 471472001231 Int/Topo IB signature motif; other site 471472001232 HMMPfam hit to PF00589, Phage integrase family,score 1.9e-39 471472001233 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 1.1e-24 471472001234 glycogen branching enzyme; Provisional; Region: PRK05402 471472001235 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 471472001236 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 471472001237 active site 471472001238 catalytic site [active] 471472001239 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 471472001240 HMMPfam hit to PF02922, Isoamylase N-terminal domain, score 1.3e-33 471472001241 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 8.5e-09 471472001242 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 471472001243 1 probable transmembrane helix predicted for CTL0246 by TMHMM2.0 at aa 33-55 471472001244 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 471472001245 1 probable transmembrane helix predicted for CTL0247 by TMHMM2.0 at aa 41-60 471472001246 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 471472001247 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 471472001248 Autotransporter beta-domain; Region: Autotransporter; pfam03797 471472001249 HMMPfam hit to PF03797, Autotransporter beta-domain,score 1.7e-38 471472001250 HMMPfam hit to PF07548, Chlamydia polymorphic membrane protei, score 3.7e-51 471472001251 PS00237 G-protein coupled receptors signature. 471472001252 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.07 471472001253 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 1 471472001254 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.79 471472001255 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 3.7 471472001256 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 2.2 471472001257 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 12 471472001258 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 1 471472001259 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 9.6 471472001260 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 471472001261 Autotransporter beta-domain; Region: Autotransporter; pfam03797 471472001262 HMMPfam hit to PF03797, Autotransporter beta-domain,score 5.2e-41 471472001263 HMMPfam hit to PF07548, Chlamydia polymorphic membrane protei, score 3.1e-53 471472001264 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 5.8 471472001265 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 5.5 471472001266 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.19 471472001267 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.15 471472001268 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 4.8 471472001269 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 7.7 471472001270 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.27 471472001271 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 2.2 471472001272 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 471472001273 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 471472001274 Autotransporter beta-domain; Region: Autotransporter; pfam03797 471472001275 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472001276 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.87 471472001277 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 1.6 471472001278 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 9.6 471472001279 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 13 471472001280 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.16 471472001281 PS00017 ATP/GTP-binding site motif A (P-loop). 471472001282 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.18 471472001283 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.011 471472001284 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 2.8 471472001285 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 12 471472001286 HMMPfam hit to PF07548, Chlamydia polymorphic membrane protei, score 3.9e-53 471472001287 HMMPfam hit to PF03797, Autotransporter beta-domain,score 3.3e-40 471472001288 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 471472001289 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 471472001290 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 471472001291 Autotransporter beta-domain; Region: Autotransporter; pfam03797 471472001292 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 2.1 471472001293 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 8.9 471472001294 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 1.1 471472001295 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.0032 471472001296 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.3 471472001297 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 50 471472001298 HMMPfam hit to PF07548, Chlamydia polymorphic membrane protei, score 9.4e-49 471472001299 HMMPfam hit to PF03797, Autotransporter beta-domain,score 4.4e-37 471472001300 PS00435 Peroxidases proximal heme-ligand signature. 471472001301 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 471472001302 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 471472001303 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 471472001304 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 471472001305 Autotransporter beta-domain; Region: Autotransporter; pfam03797 471472001306 HMMPfam hit to PF03797, Autotransporter beta-domain,score 5.5e-40 471472001307 PS00017 ATP/GTP-binding site motif A (P-loop). 471472001308 HMMPfam hit to PF07548, Chlamydia polymorphic membrane protei, score 1.7e-54 471472001309 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.54 471472001310 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.043 471472001311 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.086 471472001312 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.13 471472001313 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.075 471472001314 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.36 471472001315 Uncharacterized conserved protein [Function unknown]; Region: COG2155 471472001316 HMMPfam hit to PF04070, Domain of unknown function (DUF378), score 2.1e-43 471472001317 2 probable transmembrane helices predicted for CTL0256 by TMHMM2.0 at aa 5-27 and 42-64 471472001318 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 471472001319 HMMPfam hit to PF02686, Glu-tRNAGln amidotransferase C subunit, score 7e-32 471472001320 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 471472001321 HMMPfam hit to PF01425, Amidase, score 4.6e-213 471472001322 PS00571 Amidases signature. 471472001323 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064 471472001324 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 471472001325 GatB domain; Region: GatB_Yqey; pfam02637 471472001326 HMMPfam hit to PF02934, PET112 family, N terminal region, score 3.8e-139 471472001327 PS01234 PET112 family signature. 471472001328 HMMPfam hit to PF01162, PET112 family, C terminal region, score 1.2e-34 471472001329 HMMPfam hit to PF02637, GatB/Yqey domain, score 5.2e-54 471472001330 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 471472001331 4 probable transmembrane helices predicted for CTL0260 by TMHMM2.0 at aa 32-54, 59-81, 96-118 and 123-145 471472001332 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 471472001333 3 probable transmembrane helices predicted for CTL0261 by TMHMM2.0 at aa 47-69, 89-111 and 118-140 471472001334 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 471472001335 ribonuclease HIII; Region: rnhC; TIGR00716 471472001336 Bacterial type 2 ribonuclease, HII and HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 471472001337 RNA/DNA hybrid binding site [nucleotide binding]; other site 471472001338 active site 471472001339 HMMPfam hit to PF01351, Ribonuclease HII, score 2.5e-09 471472001340 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 471472001341 Helix-turn-helix domain; Region: HTH_25; pfam13413 471472001342 1 probable transmembrane helix predicted for CTL0264 by TMHMM2.0 at aa 117-139 471472001343 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 471472001344 putative acyl-acceptor binding pocket; other site 471472001345 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltr, score 7.2e-155 471472001346 1 probable transmembrane helix predicted for CTL0265 by TMHMM2.0 at aa 12-34 471472001347 1 probable transmembrane helix predicted for CTL0266 by TMHMM2.0 at aa 13-35 471472001348 Uncharacterized conserved protein [Function unknown]; Region: COG1624 471472001349 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 471472001350 HMMPfam hit to PF02457, Domain of unknown function DUF147, score 1.8e-67 471472001351 3 probable transmembrane helices predicted for CTL0267 by TMHMM2.0 at aa 4-26, 28-50 and 65-87 471472001352 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 471472001353 HMMPfam hit to PF01654, Bacterial Cytochrome Ubiquinol Oxidase, score 8.8e-135 471472001354 9 probable transmembrane helices predicted for CTL0268 by TMHMM2.0 at aa 10-32, 52-74, 94-116,128-150,185-207, 220-239, 321-343, 356-378 and 406-428 471472001355 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 471472001356 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 471472001357 8 probable transmembrane helices predicted for CTL0269 by TMHMM2.0 at aa 5-27, 66-88, 123-145,165-187,200-222, 237-259, 272-294 and 321-343 471472001358 HMMPfam hit to PF02322, Cytochrome oxidase subunit II, score 3.5e-183 471472001359 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 471472001360 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 471472001361 putative active site [active] 471472001362 PhoH-like protein; Region: PhoH; cl17668 471472001363 HMMPfam hit to PF02562, PhoH-like protein, score 8.8e-23 471472001364 PS00017 ATP/GTP-binding site motif A (P-loop). 471472001365 Bacterial SH3 domain homologues; Region: SH3b; smart00287 471472001366 Bacterial SH3 domain homologues; Region: SH3b; smart00287 471472001367 HMMPfam hit to PF08239, Bacterial SH3 domain, score 0.0031 471472001368 HMMPfam hit to PF08239, Bacterial SH3 domain, score 2.5e-08 471472001369 1 probable transmembrane helix predicted for CTL0273 by TMHMM2.0 at aa 25-47 471472001370 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 471472001371 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 471472001372 active site 471472001373 HIGH motif; other site 471472001374 KMSKS motif; other site 471472001375 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 471472001376 tRNA binding surface [nucleotide binding]; other site 471472001377 anticodon binding site; other site 471472001378 HMMPfam hit to PF00133, tRNA synthetases class I (I,L, M and V), score 1.3e-279 471472001379 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 471472001380 HMMPfam hit to PF08264, Anticodon-binding domain,score 4e-58 471472001381 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 471472001382 Catalytic site [active] 471472001383 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 471472001384 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 471472001385 2 probable transmembrane helices predicted for CTL0275 by TMHMM2.0 at aa 85-104 and 598-620 471472001386 PS00761 Signal peptidases I signature 3. 471472001387 HMMPfam hit to PF00717, Peptidase S24-like, score 7.1e-09 471472001388 1 probable transmembrane helix predicted for CTL0276 by TMHMM2.0 at aa 12-29 471472001389 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 471472001390 HMMPfam hit to PF01197, Ribosomal protein L31,score 1.2e-11 471472001391 PS01143 Ribosomal protein L31 signature. 471472001392 peptide chain release factor 1; Validated; Region: prfA; PRK00591 471472001393 PCRF domain; Region: PCRF; pfam03462 471472001394 RF-1 domain; Region: RF-1; pfam00472 471472001395 HMMPfam hit to PF03462, PCRF domain, score 4.4e-56 471472001396 HMMPfam hit to PF00472, Peptidyl-tRNA hydrolase domain, score 1.4e-80 471472001397 PS00745 Prokaryotic-type class I peptide chain release factors signature. 471472001398 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 471472001399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471472001400 S-adenosylmethionine binding site [chemical binding]; other site 471472001401 HMMPfam hit to PF05175, Methyltransferase small domain, score 5.4e-08 471472001402 PS00262 Insulin family signature. 471472001403 PS00092 N-6 Adenine-specific DNA methylases signature. 471472001404 signal recognition particle protein; Region: ffh; TIGR00959 471472001405 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 471472001406 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 471472001407 P loop; other site 471472001408 GTP binding site [chemical binding]; other site 471472001409 Signal peptide binding domain; Region: SRP_SPB; pfam02978 471472001410 HMMPfam hit to PF02881, SRP54-type protein, helical bundle domain, score 3.2e-31 471472001411 HMMPfam hit to PF00448, SRP54-type protein, GTPase domain, score 6.5e-111 471472001412 PS00017 ATP/GTP-binding site motif A (P-loop). 471472001413 HMMPfam hit to PF02978, Signal peptide binding domain, score 3.9e-49 471472001414 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14522 471472001415 HMMPfam hit to PF00886, Ribosomal protein S16,score 6.4e-17 471472001416 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Reviewed; Region: trmD; PRK01037 471472001417 tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmD; COG0336 471472001418 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471472001419 active site 471472001420 HMMPfam hit to PF01746, tRNA (Guanine-1)-methyltransferase, score 9.3e-53 471472001421 ribosomal protein L19, bacterial type; Region: rplS_bact; TIGR01024 471472001422 HMMPfam hit to PF01245, Ribosomal protein L19,score 7.6e-45 471472001423 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 471472001424 RNA/DNA hybrid binding site [nucleotide binding]; other site 471472001425 active site 471472001426 HMMPfam hit to PF01351, Ribonuclease HII, score 2.4e-64 471472001427 Guanylate kinase; Region: Guanylate_kin; pfam00625 471472001428 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 471472001429 catalytic site [active] 471472001430 G-X2-G-X-G-K; other site 471472001431 PS00017 ATP/GTP-binding site motif A (P-loop). 471472001432 PS00856 Guanylate kinase signature. 471472001433 HMMPfam hit to PF00625, Guanylate kinase, score 7.4e-30 471472001434 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 471472001435 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 471472001436 active site 471472001437 HIGH motif; other site 471472001438 KMSKS motif; other site 471472001439 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 471472001440 tRNA binding surface [nucleotide binding]; other site 471472001441 anticodon binding site; other site 471472001442 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 471472001443 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 471472001444 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 471472001445 AAA domain; Region: AAA_30; pfam13604 471472001446 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 471472001447 PS00017 ATP/GTP-binding site motif A (P-loop). 471472001448 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 471472001449 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 471472001450 10 probable transmembrane helices predicted for CTL0289 by TMHMM2.0 at aa 5-27, 31-48, 60-82,86-108,115-137, 147-169, 190-212, 227-246, 253-275 and 285-304 471472001451 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 471472001452 conserved cys residue [active] 471472001453 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 471472001454 2 probable transmembrane helices predicted for CTL0291 by TMHMM2.0 at aa 12-34 and 38-57 471472001455 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472001456 conserved hypothetical protein (pseudogene) 471472001457 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 471472001458 1 probable transmembrane helix predicted for CTL0293 by TMHMM2.0 at aa 21-38 471472001459 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 471472001460 trimer interface [polypeptide binding]; other site 471472001461 active site 471472001462 Holliday junction resolvasome, helicase subunit [DNA replication, recombination, and repair]; Region: RuvB; COG2255 471472001463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471472001464 Walker A motif; other site 471472001465 ATP binding site [chemical binding]; other site 471472001466 Walker B motif; other site 471472001467 arginine finger; other site 471472001468 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 471472001469 HMMPfam hit to PF05496, Holliday junction DNA helicase ruvB N-termin, score 2.1e-08 471472001470 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 1.7e-37 471472001471 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 2.4e-05 471472001472 PS00017 ATP/GTP-binding site motif A (P-loop). 471472001473 HMMPfam hit to PF05491, Holliday junction DNA helicase ruvB C-termin, score 1.9e-49 471472001474 PS00070 Aldehyde dehydrogenases cysteine active site. 471472001475 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 471472001476 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 471472001477 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 471472001478 active site 471472001479 catalytic site [active] 471472001480 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 8.6e-16 471472001481 HMMPfam hit to PF02922, Isoamylase N-terminal domain, score 1.8e-18 471472001482 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 471472001483 HMMPfam hit to PF05932, Tir chaperone protein (CesT), score 1.2e-37 471472001484 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 471472001485 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471472001486 dimer interface [polypeptide binding]; other site 471472001487 ssDNA binding site [nucleotide binding]; other site 471472001488 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471472001489 HMMPfam hit to PF00436, Single-strand binding protein family, score 6.1e-10 471472001490 multifunctional aminopeptidase A; Provisional; Region: PRK00913 471472001491 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 471472001492 interface (dimer of trimers) [polypeptide binding]; other site 471472001493 Substrate-binding/catalytic site; other site 471472001494 Zn-binding sites [ion binding]; other site 471472001495 HMMPfam hit to PF02789, Cytosol aminopeptidase family, N-term, score 2.3e-26 471472001496 HMMPfam hit to PF00883, Cytosol aminopeptidase family, cataly, score 1.8e-146 471472001497 Histone H1-like nucleoprotein HC2; Region: HC2; pfam07382 471472001498 HMMPfam hit to PF07382, Histone H1-like nucleoprotein HC2, score 4e-99 471472001499 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 471472001500 hypothetical protein; Provisional; Region: PRK05907 471472001501 HMMPfam hit to PF06144, DNA polymerase III, delta subunit, score 0.00038 471472001502 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 471472001503 putative SAM binding site [chemical binding]; other site 471472001504 homodimer interface [polypeptide binding]; other site 471472001505 PS00070 Aldehyde dehydrogenases cysteine active site. 471472001506 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 471472001507 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471472001508 FeS/SAM binding site; other site 471472001509 HemN C-terminal domain; Region: HemN_C; pfam06969 471472001510 HMMPfam hit to PF06969, HemN C-terminal region,score 3e-24 471472001511 HMMPfam hit to PF04055, Radical SAM superfamily,score 2.6e-28 471472001512 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567 471472001513 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 471472001514 TPP-binding site [chemical binding]; other site 471472001515 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 471472001516 HMMPfam hit to PF00676, Dehydrogenase E1 component,score 1.8e-43 471472001517 HMMPfam hit to PF02779, Transketolase, pyridine binding domain, score 2.6e-58 471472001518 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 471472001519 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471472001520 E3 interaction surface; other site 471472001521 lipoyl attachment site [posttranslational modification]; other site 471472001522 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 471472001523 HMMPfam hit to PF00364, Biotin-requiring enzyme,score 3.4e-13 471472001524 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 471472001525 HMMPfam hit to PF00198, 2-oxoacid dehydrogenases acyltransferas, score 4e-135 471472001526 uncharacterized protein, YfiH family; Region: TIGR00726 471472001527 HMMPfam hit to PF02578, Uncharacterised ACR, YfiH family COG1496, score 1.1e-115 471472001528 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 471472001529 GcpE protein; Region: GcpE; pfam04551 471472001530 HMMPfam hit to PF04551, GcpE protein, score 4.3e-59 471472001531 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 471472001532 ADP-ribose binding site [chemical binding]; other site 471472001533 2 probable transmembrane helices predicted for CTL0314 by TMHMM2.0 at aa 26-48 and 53-75 471472001534 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471472001535 catalytic loop [active] 471472001536 iron binding site [ion binding]; other site 471472001537 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 8.1e-13 471472001538 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 471472001539 type III secretion system protein; Validated; Region: PRK05910 471472001540 7 probable transmembrane helices predicted for CTL0316 by TMHMM2.0 at aa 33-52, 56-78, 90-112,127-149,218-237, 252-274 and 294-316 471472001541 HMMPfam hit to PF00771, FHIPEP family, score 2e-230 471472001542 RNA polymerase sigma factor sigma-28; Reviewed; Region: PRK05911 471472001543 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471472001544 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471472001545 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471472001546 DNA binding residues [nucleotide binding] 471472001547 HMMPfam hit to PF04542, Sigma-70 region, score 2.5e-21 471472001548 HMMPfam hit to PF04539, Sigma-70 region, score 9.9e-07 471472001549 HMMPfam hit to PF08281, Sigma-70, region, score 6.9e-10 471472001550 HMMPfam hit to PF04545, Sigma-70, region, score 7.2e-21 471472001551 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 471472001552 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 471472001553 active site 471472001554 HIGH motif; other site 471472001555 dimer interface [polypeptide binding]; other site 471472001556 KMSKS motif; other site 471472001557 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471472001558 RNA binding surface [nucleotide binding]; other site 471472001559 HMMPfam hit to PF00579, tRNA synthetases class I (W and Y), score 1.3e-120 471472001560 HMMPfam hit to PF01479, S4 domain, score 3.6e-08 471472001561 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 471472001562 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 471472001563 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 471472001564 HMMPfam hit to PF03446, NAD binding domain of 6-phosphogluconat, score 7.9e-88 471472001565 HMMPfam hit to PF00393, 6-phosphogluconate dehydrogenase, C-ter, score 8.7e-180 471472001566 PS00461 6-phosphogluconate dehydrogenase signature. 471472001567 GTP-binding protein LepA; Provisional; Region: PRK05433 471472001568 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 471472001569 G1 box; other site 471472001570 putative GEF interaction site [polypeptide binding]; other site 471472001571 GTP/Mg2+ binding site [chemical binding]; other site 471472001572 Switch I region; other site 471472001573 G2 box; other site 471472001574 G3 box; other site 471472001575 Switch II region; other site 471472001576 G4 box; other site 471472001577 G5 box; other site 471472001578 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 471472001579 Elongation Factor G, domain II; Region: EFG_II; pfam14492 471472001580 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 471472001581 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 471472001582 HMMPfam hit to PF06421, GTP-binding protein LepA C-terminus, score 1e-73 471472001583 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 8.7e-33 471472001584 HMMPfam hit to PF03144, Elongation factor Tu domain,score 5.7e-13 471472001585 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 6.9e-71 471472001586 PS00017 ATP/GTP-binding site motif A (P-loop). 471472001587 ADP/ATP carrier protein family; Region: AAA; TIGR00769 471472001588 HMMPfam hit to PF03219, TLC ATP/ADP transporter,score 0 471472001589 11 probable transmembrane helices predicted for CTL0321 by TMHMM2.0 at aa 27-44, 59-81, 93-115,149-171,184-206, 221-243, 284-306, 321-343, 350-372,382-401 and 456-478 471472001590 PS00430 TonB-dependent receptor proteins signature 1. 471472001591 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 471472001592 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471472001593 intersubunit interface [polypeptide binding]; other site 471472001594 HMMPfam hit to PF01297, Periplasmic solute binding protein family, score 4.8e-129 471472001595 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471472001596 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 471472001597 HMMPfam hit to PF00005, ABC transporter, score 6.7e-46 471472001598 PS00017 ATP/GTP-binding site motif A (P-loop). 471472001599 PS00211 ABC transporters family signature. 471472001600 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471472001601 ABC-ATPase subunit interface; other site 471472001602 dimer interface [polypeptide binding]; other site 471472001603 putative PBP binding regions; other site 471472001604 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 471472001605 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 471472001606 HMMPfam hit to PF00950, ABC 3 transport family,score 1.2e-13 471472001607 7 probable transmembrane helices predicted for CTL0325 by TMHMM2.0 at aa 12-34, 68-90, 102-120,143-165,190-212, 232-254 and 275-297 471472001608 HMMPfam hit to PF02742, Iron dependent repressor,metal binding, score 2.2e-14 471472001609 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 471472001610 ABC-ATPase subunit interface; other site 471472001611 dimer interface [polypeptide binding]; other site 471472001612 putative PBP binding regions; other site 471472001613 10 probable transmembrane helices predicted for CTL0326 by TMHMM2.0 at aa 5-24, 39-61, 68-90,95-114,127-144, 167-189, 202-224, 228-250, 255-277 and 287-306 471472001614 HMMPfam hit to PF00950, ABC 3 transport family,score 2.2e-11 471472001615 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 471472001616 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 471472001617 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 471472001618 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 471472001619 HMMPfam hit to PF02670, 1-deoxy-D-xylulose 5-phosphate reduct, score 5.7e-59 471472001620 HMMPfam hit to PF08436, 1-deoxy-D-xylulose 5-phosphate reduct, score 6.3e-57 471472001621 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 471472001622 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 471472001623 active site 471472001624 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 471472001625 putative substrate binding region [chemical binding]; other site 471472001626 4 probable transmembrane helices predicted for CTL0328 by TMHMM2.0 at aa 4-26, 103-125, 558-580 and 593-610 471472001627 HMMPfam hit to PF02163, Peptidase family M50, score 1e-80 471472001628 PS00142 Neutral zinc metallopeptidases,zinc-binding region signature. 471472001629 PS00136 Serine proteases, subtilase family,aspartic acid active site. 471472001630 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471472001631 Putative serine esterase (DUF676); Region: DUF676; pfam05057 471472001632 recF protein; Region: recf; TIGR00611 471472001633 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471472001634 Walker A/P-loop; other site 471472001635 ATP binding site [chemical binding]; other site 471472001636 Q-loop/lid; other site 471472001637 ABC transporter signature motif; other site 471472001638 Walker B; other site 471472001639 D-loop; other site 471472001640 H-loop/switch region; other site 471472001641 HMMPfam hit to PF02463, RecF/RecN/SMC N terminal domain, score 2.3e-10 471472001642 PS00017 ATP/GTP-binding site motif A (P-loop). 471472001643 DNA polymerase III subunit beta; Validated; Region: PRK05643 471472001644 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 471472001645 putative DNA binding surface [nucleotide binding]; other site 471472001646 dimer interface [polypeptide binding]; other site 471472001647 beta-clamp/clamp loader binding surface; other site 471472001648 beta-clamp/translesion DNA polymerase binding surface; other site 471472001649 HMMPfam hit to PF02768, DNA polymerase III beta subunit, C-te, score 9.3e-08 471472001650 HMMPfam hit to PF02767, DNA polymerase III beta subunit, cent, score 3e-23 471472001651 HMMPfam hit to PF00712, DNA polymerase III beta subunit, N-te, score 5e-21 471472001652 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 471472001653 SmpB-tmRNA interface; other site 471472001654 HMMPfam hit to PF01668, SmpB protein, score 1e-26 471472001655 PS01317 Protein smpB signature. 471472001656 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 471472001657 HMMPfam hit to PF02424, ApbE family, score 3.4e-165 471472001658 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472001659 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14181 471472001660 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 471472001661 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 471472001662 homodimer interface [polypeptide binding]; other site 471472001663 NADP binding site [chemical binding]; other site 471472001664 substrate binding site [chemical binding]; other site 471472001665 HMMPfam hit to PF02882, Tetrahydrofolate dehydrogenase/cyclohyd, score 3.5e-102 471472001666 PS00767 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. 471472001667 HMMPfam hit to PF00763, Tetrahydrofolate dehydrogenase/cyclohyd, score 1.5e-63 471472001668 2 probable transmembrane helices predicted for CTL0335 by TMHMM2.0 at aa 20-53 and 65-87 471472001669 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 471472001670 PLD-like domain; Region: PLDc_2; pfam13091 471472001671 putative active site [active] 471472001672 catalytic site [active] 471472001673 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 471472001674 PLD-like domain; Region: PLDc_2; pfam13091 471472001675 putative active site [active] 471472001676 catalytic site [active] 471472001677 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.41 471472001678 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.013 471472001679 1 probable transmembrane helix predicted for CTL0339 by TMHMM2.0 at aa 7-29 471472001680 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 471472001681 HMMPfam hit to PF01977,3-octaprenyl-4-hydroxybenzoate carboxy-lyase, score 1.9e-220 471472001682 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 471472001683 HMMPfam hit to PF00830, Ribosomal L28 family, score 4.4e-12 471472001684 4-alpha-glucanotransferase; Region: Glyco_hydro_77; pfam02446 471472001685 HMMPfam hit to PF02446,4-alpha-glucanotransferase,score 2.8e-281 471472001686 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 471472001687 HMMPfam hit to PF05932, Tir chaperone protein (CesT), score 1.1e-36 471472001688 HrpJ-like domain; Region: HrpJ; cl15454 471472001689 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 471472001690 HMMPfam hit to PF00771, FHIPEP family, score 0 471472001691 6 probable transmembrane helices predicted for CTL0345 by TMHMM2.0 at aa 27-44, 57-79, 119-141,208-230,245-267 and 309-331 471472001692 type III secretion system protein; Validated; Region: PRK06298 471472001693 HMMPfam hit to PF01312, FlhB HrpN YscU SpaS Family,score 2.2e-171 471472001694 4 probable transmembrane helices predicted for CTL0346 by TMHMM2.0 at aa 38-60, 80-102, 136-158 and 183-205 471472001695 GTP-binding protein YchF; Reviewed; Region: PRK09601 471472001696 YchF GTPase; Region: YchF; cd01900 471472001697 G1 box; other site 471472001698 GTP/Mg2+ binding site [chemical binding]; other site 471472001699 Switch I region; other site 471472001700 G2 box; other site 471472001701 Switch II region; other site 471472001702 G3 box; other site 471472001703 G4 box; other site 471472001704 G5 box; other site 471472001705 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 471472001706 PS00443 Glutamine amidotransferases class-II active site. 471472001707 HMMPfam hit to PF01926, GTPase of unknown function,score 8.9e-29 471472001708 PS00017 ATP/GTP-binding site motif A (P-loop). 471472001709 HMMPfam hit to PF06071, Protein of unknown function (DUF933), score 1.2e-48 471472001710 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 471472001711 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 471472001712 active site 471472001713 Riboflavin kinase; Region: Flavokinase; smart00904 471472001714 HMMPfam hit to PF01687, Riboflavin kinase, score 4.8e-31 471472001715 HMMPfam hit to PF06574, FAD synthetase, score 1.9e-62 471472001716 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 471472001717 RNA binding site [nucleotide binding]; other site 471472001718 active site 471472001719 HMMPfam hit to PF01509, TruB family pseudouridylate synthase (N term, score 8.2e-49 471472001720 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 471472001721 HMMPfam hit to PF02033, Ribosome-binding factor A,score 1.8e-12 471472001722 translation initiation factor IF-2; Validated; Region: infB; PRK05306 471472001723 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 471472001724 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 471472001725 G1 box; other site 471472001726 putative GEF interaction site [polypeptide binding]; other site 471472001727 GTP/Mg2+ binding site [chemical binding]; other site 471472001728 Switch I region; other site 471472001729 G2 box; other site 471472001730 G3 box; other site 471472001731 Switch II region; other site 471472001732 G4 box; other site 471472001733 G5 box; other site 471472001734 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 471472001735 Translation-initiation factor 2; Region: IF-2; pfam11987 471472001736 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 471472001737 HMMPfam hit to PF03144, Elongation factor Tu domain,score 1.9e-09 471472001738 PS01176 Initiation factor 2 signature. 471472001739 HMMPfam hit to PF03144, Elongation factor Tu domain,score 1.2e-10 471472001740 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 5.7e-46 471472001741 PS00017 ATP/GTP-binding site motif A (P-loop). 471472001742 HMMPfam hit to PF04760, Translation initiation factor IF-2, N-ter, score 1.8e-11 471472001743 transcription termination factor NusA; Region: NusA; TIGR01953 471472001744 NusA N-terminal domain; Region: NusA_N; pfam08529 471472001745 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 471472001746 RNA binding site [nucleotide binding]; other site 471472001747 homodimer interface [polypeptide binding]; other site 471472001748 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 471472001749 G-X-X-G motif; other site 471472001750 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 471472001751 G-X-X-G motif; other site 471472001752 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 471472001753 HMMPfam hit to PF00575, S1 RNA binding domain,score 4.8e-07 471472001754 HMMPfam hit to PF08529, NusA N-terminal domain,score 4.5e-62 471472001755 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 471472001756 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 471472001757 RNA binding site [nucleotide binding]; other site 471472001758 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 471472001759 RNA binding site [nucleotide binding]; other site 471472001760 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 471472001761 RNA binding site [nucleotide binding]; other site 471472001762 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471472001763 RNA binding site [nucleotide binding]; other site 471472001764 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471472001765 RNA binding site [nucleotide binding]; other site 471472001766 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 471472001767 RNA binding site [nucleotide binding]; other site 471472001768 HMMPfam hit to PF00575, S1 RNA binding domain,score 1.2e-22 471472001769 HMMPfam hit to PF00575, S1 RNA binding domain,score 8.7e-25 471472001770 HMMPfam hit to PF00575, S1 RNA binding domain,score 1.9e-25 471472001771 HMMPfam hit to PF00575, S1 RNA binding domain,score 8.9e-22 471472001772 HMMPfam hit to PF00575, S1 RNA binding domain,score 1.6e-16 471472001773 HMMPfam hit to PF00575, S1 RNA binding domain,score 5.3e-17 471472001774 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 471472001775 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 471472001776 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471472001777 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoreduc, score 2.7e-53 471472001778 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 471472001779 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreduc, score 9.2e-25 471472001780 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 471472001781 HMMPfam hit to PF01648, 4'-phosphopantetheinyl transferase superfami, score 4e-27 471472001782 2 probable transmembrane helices predicted for CTL0356 by TMHMM2.0 at aa 5-22 and 32-54 471472001783 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 471472001784 1 probable transmembrane helix predicted for CTL0357 by TMHMM2.0 at aa 43-65 471472001785 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 471472001786 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 471472001787 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471472001788 active site 471472001789 motif I; other site 471472001790 motif II; other site 471472001791 HMMPfam hit to PF08282, haloacid dehalogenase-like hydrolase, score 4e-07 471472001792 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 471472001793 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 471472001794 NAD binding site [chemical binding]; other site 471472001795 homotetramer interface [polypeptide binding]; other site 471472001796 homodimer interface [polypeptide binding]; other site 471472001797 substrate binding site [chemical binding]; other site 471472001798 active site 471472001799 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 471472001800 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471472001801 RNA binding surface [nucleotide binding]; other site 471472001802 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 471472001803 active site 471472001804 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 2.7e-52 471472001805 PS01129 Rlu family of pseudouridine synthase signature. 471472001806 HMMPfam hit to PF01479, S4 domain, score 5.4e-05 471472001807 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 471472001808 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471472001809 minor groove reading motif; other site 471472001810 helix-hairpin-helix signature motif; other site 471472001811 substrate binding pocket [chemical binding]; other site 471472001812 active site 471472001813 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 471472001814 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 471472001815 DNA binding and oxoG recognition site [nucleotide binding] 471472001816 HMMPfam hit to PF00730, HhH-GPD superfamily base excision DNA repair, score 4.4e-22 471472001817 HMMPfam hit to PF00633, Helix-hairpin-helix motif,score 2.6e-05 471472001818 Uncharacterized conserved protein [Function unknown]; Region: COG0327 471472001819 HMMPfam hit to PF01784, NIF3 (NGG1p interacting factor 3), score 2.5e-89 471472001820 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 471472001821 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 471472001822 ring oligomerisation interface [polypeptide binding]; other site 471472001823 ATP/Mg binding site [chemical binding]; other site 471472001824 stacking interactions; other site 471472001825 hinge regions; other site 471472001826 HMMPfam hit to PF00118, TCP-1/cpn60 chaperonin family, score 8.4e-187 471472001827 PS00296 Chaperonins cpn60 signature. 471472001828 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 471472001829 oligomerisation interface [polypeptide binding]; other site 471472001830 mobile loop; other site 471472001831 roof hairpin; other site 471472001832 HMMPfam hit to PF00166, Chaperonin 10 Kd subunit,score 5.2e-41 471472001833 PS00681 Chaperonins cpn10 signature. 471472001834 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 471472001835 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 471472001836 active site 471472001837 Zn binding site [ion binding]; other site 471472001838 HMMPfam hit to PF01432, Peptidase family M3, score 2.5e-165 471472001839 PS00017 ATP/GTP-binding site motif A (P-loop). 471472001840 HMMPfam hit to PF08439, Oligopeptidase F, score 4.8e-18 471472001841 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 471472001842 Clp amino terminal domain; Region: Clp_N; pfam02861 471472001843 Clp amino terminal domain; Region: Clp_N; pfam02861 471472001844 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471472001845 Walker A motif; other site 471472001846 ATP binding site [chemical binding]; other site 471472001847 Walker B motif; other site 471472001848 arginine finger; other site 471472001849 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471472001850 Walker A motif; other site 471472001851 ATP binding site [chemical binding]; other site 471472001852 Walker B motif; other site 471472001853 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 471472001854 HMMPfam hit to PF02861, Clp amino terminal domain,score 3e-10 471472001855 HMMPfam hit to PF02861, Clp amino terminal domain,score 6.6e-10 471472001856 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 1.4e-10 471472001857 PS00017 ATP/GTP-binding site motif A (P-loop). 471472001858 PS00870 Chaperonins clpA/B signature 1. 471472001859 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 1.6e-102 471472001860 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 3.2e-05 471472001861 PS00017 ATP/GTP-binding site motif A (P-loop). 471472001862 Uncharacterized conserved protein [Function unknown]; Region: COG2912 471472001863 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 471472001864 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471472001865 TPR motif; other site 471472001866 binding surface 471472001867 2 probable transmembrane helices predicted for CTL0370 by TMHMM2.0 at aa 51-73 and 83-105 471472001868 IncA protein; Region: IncA; pfam04156 471472001869 2 probable transmembrane helices predicted for CTL0371 by TMHMM2.0 at aa 39-61 and 65-87 471472001870 PS00044 Bacterial regulatory proteins, lysR family signature. 471472001871 2 probable transmembrane helices predicted for CTL0372 by TMHMM2.0 at aa 39-60 and 70-92 471472001872 2 probable transmembrane helices predicted for CTL0373 by TMHMM2.0 at aa 34-56 and 66-88 471472001873 IncA protein; Region: IncA; pfam04156 471472001874 HMMPfam hit to PF04156, IncA protein, score 1.4e-24 471472001875 2 probable transmembrane helices predicted for CTL0374 by TMHMM2.0 at aa 12-34 and 38-57 471472001876 PS00615 C-type lectin domain signature. 471472001877 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 471472001878 substrate binding site [chemical binding]; other site 471472001879 hexamer interface [polypeptide binding]; other site 471472001880 metal binding site [ion binding]; metal-binding site 471472001881 HMMPfam hit to PF00834, Ribulose-phosphate 3 epimerase family, score 3.6e-82 471472001882 PS01085 Ribulose-phosphate 3-epimerase family signature 1. 471472001883 elongation factor P; Provisional; Region: PRK12426 471472001884 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 471472001885 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471472001886 RNA binding site [nucleotide binding]; other site 471472001887 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 471472001888 RNA binding site [nucleotide binding]; other site 471472001889 HMMPfam hit to PF01132, Elongation factor P (EF-P) OB domain, score 0.00038 471472001890 PS01275 Elongation factor P signature. 471472001891 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 471472001892 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471472001893 carboxyltransferase (CT) interaction site; other site 471472001894 biotinylation site [posttranslational modification]; other site 471472001895 HMMPfam hit to PF00364, Biotin-requiring enzyme,score 1.3e-27 471472001896 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 471472001897 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471472001898 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471472001899 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 471472001900 HMMPfam hit to PF00289, Carbamoyl-phosphate synthase L chain,, score 4.2e-44 471472001901 HMMPfam hit to PF08443, RimK-like ATP-grasp domain,score 7.9e-05 471472001902 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain,, score 1.7e-94 471472001903 HMMPfam hit to PF02222, ATP-grasp domain, score 0.00089 471472001904 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 471472001905 HMMPfam hit to PF02785, Biotin carboxylase C-terminal domain, score 6e-65 471472001906 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 471472001907 23S rRNA interface [nucleotide binding]; other site 471472001908 L3 interface [polypeptide binding]; other site 471472001909 HMMPfam hit to PF00572, Ribosomal protein L13,score 5.5e-49 471472001910 PS00783 Ribosomal protein L13 signature. 471472001911 PS00063 Aldo/keto reductase family putative active site signature. 471472001912 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature. 471472001913 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 471472001914 HMMPfam hit to PF00380, Ribosomal protein S9/S16,score 5.7e-48 471472001915 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471472001916 NlpC/P60 family; Region: NLPC_P60; cl17555 471472001917 HMMPfam hit to PF00877, NlpC/P60 family, score 1.5e-08 471472001918 adenylate kinase; Reviewed; Region: adk; PRK00279 471472001919 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 471472001920 AMP-binding site [chemical binding]; other site 471472001921 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 471472001922 HMMPfam hit to PF00406, Adenylate kinase, score 5.5e-42 471472001923 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 471472001924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471472001925 dimer interface [polypeptide binding]; other site 471472001926 conserved gate region; other site 471472001927 putative PBP binding loops; other site 471472001928 ABC-ATPase subunit interface; other site 471472001929 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.5e-17 471472001930 4 probable transmembrane helices predicted for CTL0384 by TMHMM2.0 at aa 15-37, 58-80, 84-103 and 187-206 471472001931 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 471472001932 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471472001933 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471472001934 Walker A/P-loop; other site 471472001935 ATP binding site [chemical binding]; other site 471472001936 Q-loop/lid; other site 471472001937 ABC transporter signature motif; other site 471472001938 Walker B; other site 471472001939 D-loop; other site 471472001940 H-loop/switch region; other site 471472001941 HMMPfam hit to PF00005, ABC transporter, score 7.7e-54 471472001942 PS00017 ATP/GTP-binding site motif A (P-loop). 471472001943 PS00211 ABC transporters family signature. 471472001944 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 471472001945 1 probable transmembrane helix predicted for CTL0386 by TMHMM2.0 at aa 9-31 471472001946 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 471472001947 HMMPfam hit to PF03631, Ribonuclease BN-like family,score 1.5e-05 471472001948 6 probable transmembrane helices predicted for CTL0387 by TMHMM2.0 at aa 42-64, 100-122, 143-165,185-207,219-241 and 256-278 471472001949 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471472001950 S-adenosylmethionine binding site [chemical binding]; other site 471472001951 HMMPfam hit to PF08241, Methyltransferase domain,score 5.1e-12 471472001952 HMMPfam hit to PF08242, Methyltransferase domain,score 1.7e-14 471472001953 PS01186 EGF-like domain signature 2. 471472001954 2 probable transmembrane helices predicted for CTL0389 by TMHMM2.0 at aa 31-53 and 80-98 471472001955 Predicted membrane protein [Function unknown]; Region: COG4709 471472001956 4 probable transmembrane helices predicted for CTL0390 by TMHMM2.0 at aa 20-42, 121-143, 211-233 and 243-265 471472001957 Predicted esterase [General function prediction only]; Region: COG0400 471472001958 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 471472001959 HMMPfam hit to PF02230,Phospholipase/Carboxylesterase, score 2.2e-103 471472001960 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 471472001961 HMMPfam hit to PF01300, yrdC domain, score 1.9e-31 471472001962 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 471472001963 active site 471472001964 HMMPfam hit to PF01244, Membrane dipeptidase (Peptidase family, score 2.3e-13 471472001965 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 471472001966 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471472001967 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 1.6e-66 471472001968 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472001969 conserved hypothetical integral membrane protein; Region: TIGR00697 471472001970 7 probable transmembrane helices predicted for CTL0395 by TMHMM2.0 at aa 5-22, 29-51, 55-77,84-103,127-149, 165-187 and 192-214 471472001971 HMMPfam hit to PF02592, Uncharacterized ACR, YhhQ family COG1738, score 2.9e-67 471472001972 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 471472001973 SEC-C motif; Region: SEC-C; cl19389 471472001974 HMMPfam hit to PF02810, SEC-C motif, score 8.3e-10 471472001975 1 probable transmembrane helix predicted for CTL0399 by TMHMM2.0 at aa 231-253 471472001976 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471472001977 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471472001978 active site 471472001979 ATP binding site [chemical binding]; other site 471472001980 substrate binding site [chemical binding]; other site 471472001981 activation loop (A-loop); other site 471472001982 Uncharacterized conserved protein [Function unknown]; Region: COG1262 471472001983 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; pfam03781 471472001984 HMMPfam hit to PF00069, Protein kinase domain,score 1.5e-06 471472001985 HMMPfam hit to PF03781, Domain of unknown function (DUF323), score 2.3e-103 471472001986 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 471472001987 DNA ligase, NAD-dependent; Region: dnlj; TIGR00575 471472001988 nucleotide binding pocket [chemical binding]; other site 471472001989 K-X-D-G motif; other site 471472001990 catalytic site [active] 471472001991 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 471472001992 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 471472001993 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 471472001994 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 471472001995 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 471472001996 Dimer interface [polypeptide binding]; other site 471472001997 HMMPfam hit to PF01653, NAD-dependent DNA ligase adenylation, score 3.6e-102 471472001998 HMMPfam hit to PF03120, NAD-dependent DNA ligase OB-fold doma, score 9.5e-49 471472001999 PS01056 NAD-dependent DNA ligase signature 2. 471472002000 HMMPfam hit to PF03119, NAD-dependent DNA ligase C4 zinc fing, score 1.6e-08 471472002001 HMMPfam hit to PF00633, Helix-hairpin-helix motif,score 4.4e-08 471472002002 HMMPfam hit to PF00533, BRCA1 C Terminus (BRCT) domain, score 1.3e-17 471472002003 Synaptonemal complex protein 1 (SCP-1); Region: SCP-1; pfam05483 471472002004 4 probable transmembrane helices predicted for CTL0402 by TMHMM2.0 at aa 76-98, 100-122, 848-870 and 877-899 471472002005 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 471472002006 HMMPfam hit to PF01494, FAD binding domain, score 9.2e-05 471472002007 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 471472002008 Putative lysophospholipase; Region: Hydrolase_4; cl19140 471472002009 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 471472002010 HMMPfam hit to PF00471, Ribosomal protein L33,score 2.8e-14 471472002011 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471472002012 FtsX-like permease family; Region: FtsX; pfam02687 471472002013 4 probable transmembrane helices predicted for CTL0406 by TMHMM2.0 at aa 21-43, 364-386, 407-429 and 464-486 471472002014 HMMPfam hit to PF02687, Predicted permease, score 3.7e-40 471472002015 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471472002016 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471472002017 Walker A/P-loop; other site 471472002018 ATP binding site [chemical binding]; other site 471472002019 Q-loop/lid; other site 471472002020 ABC transporter signature motif; other site 471472002021 Walker B; other site 471472002022 D-loop; other site 471472002023 H-loop/switch region; other site 471472002024 HMMPfam hit to PF00005, ABC transporter, score 7.7e-55 471472002025 PS00017 ATP/GTP-binding site motif A (P-loop). 471472002026 PS00211 ABC transporters family signature. 471472002027 membrane-attack complex / perforin; Region: MACPF; smart00457 471472002028 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; Region: MIR; smart00472 471472002029 HMMPfam hit to PF01823, MAC/Perforin domain, score 1.1e-63 471472002030 phosphatidylcholine-hydrolyzing phospholipase D (PLD) protein (pseudogene) 471472002031 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.55 471472002032 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 2 471472002033 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 471472002034 PLD-like domain; Region: PLDc_2; pfam13091 471472002035 putative active site [active] 471472002036 catalytic site [active] 471472002037 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 471472002038 PLD-like domain; Region: PLDc_2; pfam13091 471472002039 putative active site [active] 471472002040 catalytic site [active] 471472002041 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 1.6 471472002042 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.009 471472002043 indel in L2 and Harl13: acgattccg 471472002044 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 471472002045 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 471472002046 putative active site [active] 471472002047 catalytic site [active] 471472002048 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 471472002049 putative active site [active] 471472002050 catalytic site [active] 471472002051 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 1.3 471472002052 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.026 471472002053 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 471472002054 PLD-like domain; Region: PLDc_2; pfam13091 471472002055 putative active site [active] 471472002056 catalytic site [active] 471472002057 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 2.3 471472002058 putative membrane protein (pseudogene) 471472002059 1 probable transmembrane helix predicted for CTL0418 by TMHMM2.0 at aa 47-69 471472002060 1 probable transmembrane helix predicted for CTL0419 by TMHMM2.0 at aa 63-85 471472002061 HMMPfam hit to PF00612, IQ calmodulin-binding motif,score 0.00048 471472002062 PS00018 EF-hand calcium-binding domain. 471472002063 1 probable transmembrane helix predicted for CTL0419A by TMHMM2.0 at aa 31-53 471472002064 cytotoxin (remnant) 471472002065 cytotoxin (fragment) 471472002066 trp operon repressor, proteobacterial; Region: TrpR; TIGR01321 471472002067 HMMPfam hit to PF01371, Trp repressor protein,score 6.9e-41 471472002068 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 471472002069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471472002070 catalytic residue [active] 471472002071 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 5.7e-121 471472002072 PS00168 Tryptophan synthase beta chain pyridoxal-phosphate attachment site. 471472002073 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 471472002074 substrate binding site [chemical binding]; other site 471472002075 active site 471472002076 catalytic residues [active] 471472002077 heterodimer interface [polypeptide binding]; other site 471472002078 HMMPfam hit to PF00290, Tryptophan synthase alpha chain, score 2.4e-19 471472002079 conserved hypothetical protein (pseudogene) 471472002080 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 471472002081 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 471472002082 peptide binding site [polypeptide binding]; other site 471472002083 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472002084 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 3.5e-70 471472002085 putative disulfide oxidoreductase; Provisional; Region: PRK00611 471472002086 HMMPfam hit to PF02600, Disulfide bond formation protein DsbB, score 2.3e-64 471472002087 4 probable transmembrane helices predicted for CTL0428 by TMHMM2.0 at aa 7-29, 39-58, 71-93 and 108-130 471472002088 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472002089 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 471472002090 Thioredoxin; Region: Thioredoxin_4; cl17273 471472002091 1 probable transmembrane helix predicted for CTL0429 by TMHMM2.0 at aa 12-29 471472002092 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 471472002093 putative active site [active] 471472002094 redox center [active] 471472002095 10 probable transmembrane helices predicted for CTL0430 by TMHMM2.0 at aa 17-39, 54-76, 89-111,141-163,170-192, 202-224, 303-325, 335-352, 359-381 and 385-402 471472002096 2 probable transmembrane helices predicted for CTL0431 by TMHMM2.0 at aa 2-24 and 29-51 471472002097 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471472002098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471472002099 Walker A/P-loop; other site 471472002100 ATP binding site [chemical binding]; other site 471472002101 Q-loop/lid; other site 471472002102 ABC transporter signature motif; other site 471472002103 Walker B; other site 471472002104 D-loop; other site 471472002105 H-loop/switch region; other site 471472002106 HMMPfam hit to PF00005, ABC transporter, score 3.2e-40 471472002107 PS00211 ABC transporters family signature. 471472002108 PS00017 ATP/GTP-binding site motif A (P-loop). 471472002109 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 471472002110 Ligand binding site; other site 471472002111 oligomer interface; other site 471472002112 HMMPfam hit to PF02348, Cytidylyltransferase, score 7.6e-94 471472002113 CTP synthetase; Validated; Region: pyrG; PRK05380 471472002114 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 471472002115 Catalytic site [active] 471472002116 active site 471472002117 UTP binding site [chemical binding]; other site 471472002118 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 471472002119 active site 471472002120 putative oxyanion hole; other site 471472002121 catalytic triad [active] 471472002122 HMMPfam hit to PF06418, CTP synthase N-terminus,score 5.6e-192 471472002123 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 7.2e-73 471472002124 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 471472002125 HMMPfam hit to PF03652, Uncharacterised protein family (UPF0081), score 7.6e-60 471472002126 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 471472002127 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 471472002128 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 471472002129 HMMPfam hit to PF00479, Glucose-6-phosphate dehydrogenase, NAD bindi, score 2.6e-47 471472002130 PS00069 Glucose-6-phosphate dehydrogenase active site. 471472002131 HMMPfam hit to PF02781, Glucose-6-phosphate dehydrogenase, C-termina, score 3e-125 471472002132 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 471472002133 putative active site [active] 471472002134 DNA polymerase III subunit delta'; Validated; Region: PRK05917 471472002135 DNA polymerase III subunit delta'; Validated; Region: PRK08485 471472002136 thymidylate kinase; Validated; Region: tmk; PRK00698 471472002137 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 471472002138 TMP-binding site; other site 471472002139 ATP-binding site [chemical binding]; other site 471472002140 HMMPfam hit to PF02223, Thymidylate kinase, score 8.7e-86 471472002141 PS01331 Thymidylate kinase signature. 471472002142 PS00017 ATP/GTP-binding site motif A (P-loop). 471472002143 DNA gyrase, A subunit; Region: gyrA; TIGR01063 471472002144 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 471472002145 CAP-like domain; other site 471472002146 active site 471472002147 primary dimer interface [polypeptide binding]; other site 471472002148 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471472002149 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471472002150 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471472002151 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471472002152 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471472002153 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471472002154 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 1.1e-11 471472002155 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 2.5e-10 471472002156 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 1.1e-15 471472002157 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 1.6e-09 471472002158 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 1.9e-11 471472002159 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 3.7e-11 471472002160 HMMPfam hit to PF00521, DNA gyrase/topoisomerase IV,subunit A, score 6.6e-300 471472002161 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 471472002162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471472002163 ATP binding site [chemical binding]; other site 471472002164 Mg2+ binding site [ion binding]; other site 471472002165 G-X-G motif; other site 471472002166 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 471472002167 anchoring element; other site 471472002168 dimer interface [polypeptide binding]; other site 471472002169 ATP binding site [chemical binding]; other site 471472002170 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 471472002171 active site 471472002172 putative metal-binding site [ion binding]; other site 471472002173 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 471472002174 HMMPfam hit to PF00986, DNA gyrase B subunit,carboxyl terminus, score 1.4e-44 471472002175 HMMPfam hit to PF01751, Toprim domain, score 1.2e-10 471472002176 PS00177 DNA topoisomerase II signature. 471472002177 HMMPfam hit to PF00204, DNA gyrase B, score 1.6e-91 471472002178 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and H, score 1.5e-27 471472002179 Protein of unknown function (DUF721); Region: DUF721; pfam05258 471472002180 2 probable transmembrane helices predicted for CTL0444 by TMHMM2.0 at aa 33-55 and 60-82 471472002181 queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008 471472002182 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 471472002183 HMMPfam hit to PF01702, Queuine tRNA-ribosyltransferase, score 1.3e-54 471472002184 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 471472002185 MgtE intracellular N domain; Region: MgtE_N; pfam03448 471472002186 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 471472002187 Divalent cation transporter; Region: MgtE; pfam01769 471472002188 5 probable transmembrane helices predicted for CTL0446 by TMHMM2.0 at aa 291-313, 320-342, 375-397,409-431 and 451-469 471472002189 HMMPfam hit to PF01769, Divalent cation transporter,score 1.8e-54 471472002190 HMMPfam hit to PF00571, CBS domain pair, score 7.7e-17 471472002191 HMMPfam hit to PF03448, MgtE intracellular domain,score 3.1e-32 471472002192 3 probable transmembrane helices predicted for CTL0447 by TMHMM2.0 at aa 53-75, 85-107 and 175-197 471472002193 2 probable transmembrane helices predicted for CTL0448 by TMHMM2.0 at aa 34-56 and 63-85 471472002194 Metal-dependent proteases with possible chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: QRI7; COG0533 471472002195 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 471472002196 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 471472002197 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471472002198 HMMPfam hit to PF00814, Glycoprotease family, score 4.4e-69 471472002199 PS01016 Glycoprotease family signature. 471472002200 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 471472002201 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 471472002202 peptide binding site [polypeptide binding]; other site 471472002203 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472002204 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 7.7e-67 471472002205 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471472002206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471472002207 dimer interface [polypeptide binding]; other site 471472002208 conserved gate region; other site 471472002209 putative PBP binding loops; other site 471472002210 ABC-ATPase subunit interface; other site 471472002211 7 probable transmembrane helices predicted for CTL0451 by TMHMM2.0 at aa 9-31, 102-124, 133-155,175-197,218-240, 245-264 and 277-299 471472002212 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.2e-42 471472002213 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471472002214 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 471472002215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471472002216 dimer interface [polypeptide binding]; other site 471472002217 conserved gate region; other site 471472002218 putative PBP binding loops; other site 471472002219 ABC-ATPase subunit interface; other site 471472002220 6 probable transmembrane helices predicted for CTL0452 by TMHMM2.0 at aa 19-41, 80-102, 122-141,145-167,191-213 and 241-263 471472002221 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 5.1e-37 471472002222 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471472002223 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 471472002224 Walker A/P-loop; other site 471472002225 ATP binding site [chemical binding]; other site 471472002226 Q-loop/lid; other site 471472002227 ABC transporter signature motif; other site 471472002228 Walker B; other site 471472002229 D-loop; other site 471472002230 H-loop/switch region; other site 471472002231 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471472002232 HMMPfam hit to PF00005, ABC transporter, score 1.5e-49 471472002233 PS00017 ATP/GTP-binding site motif A (P-loop). 471472002234 PS00211 ABC transporters family signature. 471472002235 HMMPfam hit to PF08352, Oligopeptide/dipeptide transporter, C-termi, score 8.6e-06 471472002236 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 471472002237 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471472002238 Walker A/P-loop; other site 471472002239 ATP binding site [chemical binding]; other site 471472002240 Q-loop/lid; other site 471472002241 ABC transporter signature motif; other site 471472002242 Walker B; other site 471472002243 D-loop; other site 471472002244 H-loop/switch region; other site 471472002245 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471472002246 HMMPfam hit to PF00005, ABC transporter, score 2.8e-55 471472002247 PS00017 ATP/GTP-binding site motif A (P-loop). 471472002248 PS00211 ABC transporters family signature. 471472002249 Protein of unknown function (DUF1186); Region: DUF1186; pfam06685 471472002250 HMMPfam hit to PF06685, Protein of unknown function (DUF1186), score 8.3e-194 471472002251 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 471472002252 anion transporter; Region: dass; TIGR00785 471472002253 transmembrane helices; other site 471472002254 HMMPfam hit to PF00939, Sodium:sulfate symporter transmembrane, score 9.2e-275 471472002255 10 probable transmembrane helices predicted for CTL0456 by TMHMM2.0 at aa 7-29, 44-66, 120-142,178-200,213-235, 281-303, 324-346, 361-378, 390-412 and 445-467 471472002256 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 471472002257 active site 471472002258 ADP/pyrophosphate binding site [chemical binding]; other site 471472002259 dimerization interface [polypeptide binding]; other site 471472002260 allosteric effector site; other site 471472002261 fructose-1,6-bisphosphate binding site; other site 471472002262 HMMPfam hit to PF00365, Phosphofructokinase, score 1.1e-09 471472002263 Putative lysophospholipase; Region: Hydrolase_4; cl19140 471472002264 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471472002265 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 471472002266 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 471472002267 active site 471472002268 ADP/pyrophosphate binding site [chemical binding]; other site 471472002269 dimerization interface [polypeptide binding]; other site 471472002270 allosteric effector site; other site 471472002271 fructose-1,6-bisphosphate binding site; other site 471472002272 HMMPfam hit to PF00365, Phosphofructokinase, score 5e-08 471472002273 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 471472002274 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 471472002275 PS00017 ATP/GTP-binding site motif A (P-loop). 471472002276 HMMPfam hit to PF04413,3-Deoxy-D-manno-octulosonic-acid tran, score 1.6e-102 471472002277 1 probable transmembrane helix predicted for CTL0460 by TMHMM2.0 at aa 5-27 471472002278 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 471472002279 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 471472002280 active site 471472002281 HIGH motif; other site 471472002282 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 471472002283 KMSKS motif; other site 471472002284 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 471472002285 tRNA binding surface [nucleotide binding]; other site 471472002286 HMMPfam hit to PF08264, Anticodon-binding domain,score 3e-07 471472002287 HMMPfam hit to PF00133, tRNA synthetases class I (I,L, M and V), score 9.4e-13 471472002288 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 471472002289 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 471472002290 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471472002291 inhibitor-cofactor binding pocket; inhibition site 471472002292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471472002293 catalytic residue [active] 471472002294 HMMPfam hit to PF00202, Aminotransferase class-III,score 1.2e-48 471472002295 PS00435 Peroxidases proximal heme-ligand signature. 471472002296 Putative transcriptional regulator [Transcription]; Region: COG1678 471472002297 HMMPfam hit to PF02622, Uncharacterized ACR,COG1678,score 3.8e-88 471472002298 Uncharacterized conserved protein [Function unknown]; Region: COG1259 471472002299 HMMPfam hit to PF02577, Uncharacterised ACR,COG1259,score 2.5e-85 471472002300 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 471472002301 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471472002302 active site 471472002303 dimer interface [polypeptide binding]; other site 471472002304 HMMPfam hit to PF06026, Ribose 5-phosphate isomerase A (phosph, score 7.7e-85 471472002305 2 probable transmembrane helices predicted for CTL0466 by TMHMM2.0 at aa 36-58 and 68-90 471472002306 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 471472002307 putative active site; other site 471472002308 catalytic residue [active] 471472002309 HMMPfam hit to PF01791, DeoC/LacD family aldolase,score 6.3e-58 471472002310 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 471472002311 12 probable transmembrane helices predicted for CTL0468 by TMHMM2.0 at aa 7-26, 41-63, 83-105,120-142,149-171, 191-210, 231-253, 277-299, 328-350,357-379,400-422 and 437-459 471472002312 HMMPfam hit to PF00324, Amino acid permease, score 1.2e-05 471472002313 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 471472002314 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 471472002315 Ligand Binding Site [chemical binding]; other site 471472002316 HMMPfam hit to PF01171, PP-loop family, score 4.2e-08 471472002317 Predicted acid phosphatase [General function prediction only]; Region: SurE; COG0496 471472002318 HMMPfam hit to PF01975, Survival protein SurE,score 5.9e-105 471472002319 PS00063 Aldo/keto reductase family putative active site signature. 471472002320 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 471472002321 putative active site [active] 471472002322 HMMPfam hit to PF01040, UbiA prenyltransferase family, score 3.4e-71 471472002323 9 probable transmembrane helices predicted for CTL0471 by TMHMM2.0 at aa 21-43, 48-70, 90-109,113-135,140-162, 166-185, 216-238, 242-264 and 277-299 471472002324 aromatic acid decarboxylase; Validated; Region: PRK05920 471472002325 HMMPfam hit to PF02441, Flavoprotein, score 1.6e-47 471472002326 1 probable transmembrane helix predicted for CTL0472 by TMHMM2.0 at aa 5-27 471472002327 Uncharacterized conserved protein [Function unknown]; Region: COG1284 471472002328 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471472002329 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 471472002330 6 probable transmembrane helices predicted for CTL0473 by TMHMM2.0 at aa 20-39, 54-76, 83-105,125-142,163-185 and 190-212 471472002331 HMMPfam hit to PF02588, Uncharacterized BCR, YitT family COG1284, score 7.5e-20 471472002332 HMMPfam hit to PF02588, Uncharacterized BCR, YitT family COG1284, score 1e-18 471472002333 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472002334 IncA protein; Region: IncA; pfam04156 471472002335 HMMPfam hit to PF04156, IncA protein, score 2.1e-11 471472002336 2 probable transmembrane helices predicted for CTL0475 by TMHMM2.0 at aa 39-61 and 66-88 471472002337 IncA protein; Region: IncA; pfam04156 471472002338 Syntaxin-like protein; Region: Syntaxin_2; pfam14523 471472002339 HMMPfam hit to PF04156, IncA protein, score 1.1e-38 471472002340 2 probable transmembrane helices predicted for CTL0476 by TMHMM2.0 at aa 38-60 and 67-89 471472002341 IncA protein; Region: IncA; pfam04156 471472002342 2 probable transmembrane helices predicted for CTL0477 by TMHMM2.0 at aa 35-57 and 62-84 471472002343 2 probable transmembrane helices predicted for CTL0477A by TMHMM2.0 at aa 13-35 and 45-67 471472002344 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472002345 2 probable transmembrane helices predicted for CTL0478 by TMHMM2.0 at aa 40-62 and 72-94 471472002346 2 probable transmembrane helices predicted for CTL0479 by TMHMM2.0 at aa 36-58 and 68-90 471472002347 IncA protein; Region: IncA; pfam04156 471472002348 HMMPfam hit to PF04156, IncA protein, score 1.3e-41 471472002349 2 probable transmembrane helices predicted for CTL0480 by TMHMM2.0 at aa 37-59 and 64-86 471472002350 IncA protein; Region: IncA; pfam04156 471472002351 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 471472002352 HMMPfam hit to PF04156, IncA protein, score 1.7e-38 471472002353 2 probable transmembrane helices predicted for CTL0481 by TMHMM2.0 at aa 43-65 and 69-91 471472002354 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 471472002355 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 1.4e-10 471472002356 9 probable transmembrane helices predicted for CTL0482 by TMHMM2.0 at aa 21-43, 53-70, 83-105,146-164,177-199, 219-241, 292-314, 329-351 and 356-378 471472002357 Na+-dependent transporters of the SNF family [General function prediction only]; Region: COG0733 471472002358 12 probable transmembrane helices predicted for CTL0483 by TMHMM2.0 at aa 7-29, 44-66, 87-109,138-157,170-189, 245-267, 279-301, 316-338, 351-373,378-400,420-442 and 457-479 471472002359 HMMPfam hit to PF00209, Sodium:neurotransmitter symporter family, score 2.2e-11 471472002360 2 probable transmembrane helices predicted for CTL0484 by TMHMM2.0 at aa 30-52 and 67-89 471472002361 2 probable transmembrane helices predicted for CTL0485 by TMHMM2.0 at aa 110-132 and 142-164 471472002362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471472002363 putative substrate translocation pore; other site 471472002364 11 probable transmembrane helices predicted for CTL0486 by TMHMM2.0 at aa 28-47, 62-84, 93-115,125-146,159-177, 187-206, 241-263, 283-302, 309-331,394-416 and 670-692 471472002365 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471472002366 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471472002367 ligand binding site [chemical binding]; other site 471472002368 flexible hinge region; other site 471472002369 HMMPfam hit to PF00027, Cyclic nucleotide-binding domain, score 1.7e-21 471472002370 acyl carrier protein; Provisional; Region: acpP; PRK00982 471472002371 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 3.8e-18 471472002372 PS00012 Phosphopantetheine attachment site. 471472002373 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 471472002374 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 471472002375 NAD(P) binding site [chemical binding]; other site 471472002376 homotetramer interface [polypeptide binding]; other site 471472002377 homodimer interface [polypeptide binding]; other site 471472002378 active site 471472002379 HMMPfam hit to PF00106, short chain dehydrogenase,score 2.7e-38 471472002380 PS00061 Short-chain dehydrogenases/reductases family signature. 471472002381 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 471472002382 HMMPfam hit to PF00698, Acyl transferase domain,score 2.4e-10 471472002383 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 471472002384 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 471472002385 dimer interface [polypeptide binding]; other site 471472002386 active site 471472002387 CoA binding pocket [chemical binding]; other site 471472002388 HMMPfam hit to PF08541,3-Oxoacyl-[acyl-carrier-protein (ACP)], score 4.4e-40 471472002389 HMMPfam hit to PF08545,3-Oxoacyl-[acyl-carrier-protein (ACP)], score 5.2e-38 471472002390 recombination protein RecR; Region: recR; TIGR00615 471472002391 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 471472002392 putative active site [active] 471472002393 putative metal-binding site [ion binding]; other site 471472002394 tetramer interface [polypeptide binding]; other site 471472002395 HMMPfam hit to PF01751, Toprim domain, score 1.8e-14 471472002396 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 471472002397 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 471472002398 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 471472002399 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 471472002400 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 471472002401 Surface antigen; Region: Bac_surface_Ag; pfam01103 471472002402 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 5.1e-17 471472002403 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 2.4e-12 471472002404 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 3.8e-12 471472002405 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 1.2e-13 471472002406 HMMPfam hit to PF01103, Surface antigen, score 8e-30 471472002407 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 471472002408 HMMPfam hit to PF03938, Outer membrane protein (OmpH-like), score 1.5e-35 471472002409 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 471472002410 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 471472002411 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 471472002412 trimer interface [polypeptide binding]; other site 471472002413 active site 471472002414 UDP-GlcNAc binding site [chemical binding]; other site 471472002415 lipid binding site [chemical binding]; lipid-binding site 471472002416 HMMPfam hit to PF04613,UDP-3-O-[3-hydroxymyristoyl] glucosamine N-a, score 1e-43 471472002417 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1.3 471472002418 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.47 471472002419 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1.3 471472002420 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.025 471472002421 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.076 471472002422 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 15 471472002423 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 18 471472002424 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.69 471472002425 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 471472002426 tetramer interface [polypeptide binding]; other site 471472002427 TPP-binding site [chemical binding]; other site 471472002428 heterodimer interface [polypeptide binding]; other site 471472002429 phosphorylation loop region [posttranslational modification] 471472002430 HMMPfam hit to PF00676, Dehydrogenase E1 component,score 6.6e-72 471472002431 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 471472002432 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 471472002433 alpha subunit interface [polypeptide binding]; other site 471472002434 TPP binding site [chemical binding]; other site 471472002435 heterodimer interface [polypeptide binding]; other site 471472002436 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471472002437 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 3.7e-73 471472002438 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 1.9e-55 471472002439 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 471472002440 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471472002441 E3 interaction surface; other site 471472002442 lipoyl attachment site [posttranslational modification]; other site 471472002443 e3 binding domain; Region: E3_binding; pfam02817 471472002444 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 471472002445 HMMPfam hit to PF00364, Biotin-requiring enzyme,score 1.6e-14 471472002446 HMMPfam hit to PF02817, e3 binding domain, score 5.9e-19 471472002447 HMMPfam hit to PF00198, 2-oxoacid dehydrogenases acyltransferas, score 3.1e-113 471472002448 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 471472002449 homodimer interface [polypeptide binding]; other site 471472002450 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 471472002451 active site pocket [active] 471472002452 HMMPfam hit to PF00343, Carbohydrate phosphorylase,score 0 471472002453 PS00102 Phosphorylase pyridoxal-phosphate attachment site. 471472002454 2 probable transmembrane helices predicted for CTL0500A by TMHMM2.0 at aa 51-73 and 77-99 471472002455 chromosomal replication initiation protein; Provisional; Region: PRK12422 471472002456 DnaA N-terminal domain; Region: DnaA_N; pfam11638 471472002457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471472002458 Walker A motif; other site 471472002459 ATP binding site [chemical binding]; other site 471472002460 Walker B motif; other site 471472002461 arginine finger; other site 471472002462 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 471472002463 DnaA box-binding interface [nucleotide binding]; other site 471472002464 HMMPfam hit to PF08299, Bacterial dnaA protein helix-turn-helix, score 2.1e-24 471472002465 HMMPfam hit to PF00308, Bacterial dnaA protein,score 6.2e-40 471472002466 PS00017 ATP/GTP-binding site motif A (P-loop). 471472002467 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 471472002468 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 471472002469 HMMPfam hit to PF02096, 60Kd inner membrane protein,score 1.9e-114 471472002470 5 probable transmembrane helices predicted for CTL0503 by TMHMM2.0 at aa 7-26, 566-588, 633-655, 686-708 and 734-756 471472002471 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472002472 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 471472002473 HMMPfam hit to PF01790, Prolipoprotein diacylglyceryl transferase, score 2.4e-91 471472002474 7 probable transmembrane helices predicted for CTL0504 by TMHMM2.0 at aa 20-42, 62-84, 94-116,129-151,184-203, 210-232 and 247-269 471472002475 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472002476 CAAX protease self-immunity; Region: Abi; pfam02517 471472002477 6 probable transmembrane helices predicted for CTL0506 by TMHMM2.0 at aa 4-25, 32-54, 69-91,112-134,158-180 and 208-230 471472002478 HMMPfam hit to PF02517, CAAX amino terminal protease family, score 1.1e-30 471472002479 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 471472002480 homodimer interface [polypeptide binding]; other site 471472002481 metal binding site [ion binding]; metal-binding site 471472002482 HMMPfam hit to PF03819, MazG nucleotide pyrophosphohydrolase domain, score 4.7e-26 471472002483 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471472002484 Domain of unknown function DUF21; Region: DUF21; pfam01595 471472002485 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 471472002486 Transporter associated domain; Region: CorC_HlyC; smart01091 471472002487 HMMPfam hit to PF01595, Domain of unknown function DUF21, score 2.7e-38 471472002488 3 probable transmembrane helices predicted for CTL0508 by TMHMM2.0 at aa 5-27, 52-74 and 81-103 471472002489 HMMPfam hit to PF00571, CBS domain pair, score 7.5e-09 471472002490 HMMPfam hit to PF03471, Transporter associated domain, score 1.3e-22 471472002491 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471472002492 Domain of unknown function DUF21; Region: DUF21; pfam01595 471472002493 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 471472002494 Transporter associated domain; Region: CorC_HlyC; smart01091 471472002495 3 probable transmembrane helices predicted for CTL0509 by TMHMM2.0 at aa 7-29, 95-114 and 135-157 471472002496 HMMPfam hit to PF01595, Domain of unknown function DUF21, score 8.1e-47 471472002497 HMMPfam hit to PF00571, CBS domain pair, score 5.1e-11 471472002498 HMMPfam hit to PF03471, Transporter associated domain, score 2.7e-15 471472002499 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 471472002500 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471472002501 catalytic residue [active] 471472002502 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 0.00014 471472002503 HMMPfam hit to PF00266, Aminotransferase class-V,score 2.2e-31 471472002504 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 471472002505 active site 471472002506 HMMPfam hit to PF00481, Protein phosphatase 2C,score 0.0001 471472002507 Uncharacterized conserved protein [Function unknown]; Region: COG5465 471472002508 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 471472002509 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 471472002510 active site 471472002511 catalytic site [active] 471472002512 substrate binding site [chemical binding]; other site 471472002513 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 471472002514 HMMPfam hit to PF00929, Exonuclease, score 5e-54 471472002515 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 471472002516 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 471472002517 HMMPfam hit to PF02642, Uncharacterized ACR,COG2107,score 2.5e-180 471472002518 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 471472002519 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471472002520 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471472002521 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471472002522 Walker A/P-loop; other site 471472002523 ATP binding site [chemical binding]; other site 471472002524 Q-loop/lid; other site 471472002525 ABC transporter signature motif; other site 471472002526 Walker B; other site 471472002527 D-loop; other site 471472002528 H-loop/switch region; other site 471472002529 HMMPfam hit to PF00005, ABC transporter, score 1.9e-51 471472002530 PS00211 ABC transporters family signature. 471472002531 PS00017 ATP/GTP-binding site motif A (P-loop). 471472002532 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 9.3e-06 471472002533 5 probable transmembrane helices predicted for CTL0516 by TMHMM2.0 at aa 20-42, 125-147, 195-217, 221-243 and 312-334 471472002534 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 471472002535 PS00070 Aldehyde dehydrogenases cysteine active site. 471472002536 HMMPfam hit to PF03255, Acetyl co-enzyme A carboxylase carboxyltrans, score 1.4e-93 471472002537 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 471472002538 dimer interface [polypeptide binding]; other site 471472002539 DNA binding site [nucleotide binding] 471472002540 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 2.7e-33 471472002541 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 471472002542 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 471472002543 active site 471472002544 metal binding site [ion binding]; metal-binding site 471472002545 HMMPfam hit to PF01520, N-acetylmuramoyl-L-alanine amidase, score 9.3e-89 471472002546 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 471472002547 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471472002548 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471472002549 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471472002550 HMMPfam hit to PF02875, Mur ligase family,glutamate ligase doma, score 1.4e-28 471472002551 HMMPfam hit to PF08245, Mur ligase middle domain,score 6.5e-75 471472002552 PS01011 Folylpolyglutamate synthase signature 1. 471472002553 HMMPfam hit to PF01225, Mur ligase family,catalytic domain, score 6.6e-14 471472002554 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 471472002555 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 471472002556 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 471472002557 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 6.2e-48 471472002558 PS00017 ATP/GTP-binding site motif A (P-loop). 471472002559 HMMPfam hit to PF03717, Penicillin-binding Protein dimerisatio, score 2.5e-29 471472002560 1 probable transmembrane helix predicted for CTL0522 by TMHMM2.0 at aa 7-26 471472002561 MraW methylase family; Region: Methyltransf_5; pfam01795 471472002562 HMMPfam hit to PF01795, MraW methylase family,score 1.8e-172 471472002563 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471472002564 TPR motif; other site 471472002565 binding surface 471472002566 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 471472002567 DnaA N-terminal domain; Region: DnaA_N; pfam11638 471472002568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471472002569 Walker A motif; other site 471472002570 ATP binding site [chemical binding]; other site 471472002571 Walker B motif; other site 471472002572 arginine finger; other site 471472002573 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 471472002574 DnaA box-binding interface [nucleotide binding]; other site 471472002575 HMMPfam hit to PF00308, Bacterial dnaA protein,score 1.6e-101 471472002576 PS00017 ATP/GTP-binding site motif A (P-loop). 471472002577 HMMPfam hit to PF08299, Bacterial dnaA protein helix-turn-helix, score 1.1e-26 471472002578 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 471472002579 HMMPfam hit to PF04519, Protein of unknown function,DUF583, score 2.7e-45 471472002580 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024 471472002581 HMMPfam hit to PF03116, NQR2, RnfD, RnfE family,score 0 471472002582 8 probable transmembrane helices predicted for CTL0530 by TMHMM2.0 at aa 57-79, 120-142, 155-177,356-378,385-407, 417-436, 449-468 and 473-495 471472002583 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 471472002584 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 471472002585 1 probable transmembrane helix predicted for CTL0531 by TMHMM2.0 at aa 13-35 471472002586 HMMPfam hit to PF04205, FMN-binding domain, score 4.9e-24 471472002587 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD [Energy production and conversion]; Region: NqrD; COG1347 471472002588 HMMPfam hit to PF02508, Rnf-Nqr subunit, membrane protein, score 2.3e-94 471472002589 6 probable transmembrane helices predicted for CTL0532 by TMHMM2.0 at aa 13-35, 40-62, 69-86,92-114,141-163 and 183-205 471472002590 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061 471472002591 HMMPfam hit to PF02508, Rnf-Nqr subunit, membrane protein, score 7.3e-111 471472002592 6 probable transmembrane helices predicted for CTL0533 by TMHMM2.0 at aa 13-35, 48-70, 90-112,119-141,151-173 and 186-208 471472002593 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 471472002594 lipoyl attachment site [posttranslational modification]; other site 471472002595 HMMPfam hit to PF01597, Glycine cleavage H-protein,score 3.5e-12 471472002596 HMMPfam hit to PF00364, Biotin-requiring enzyme,score 0.00088 471472002597 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 471472002598 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 471472002599 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 471472002600 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 471472002601 putative active site [active] 471472002602 catalytic site [active] 471472002603 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 471472002604 putative active site [active] 471472002605 catalytic site [active] 471472002606 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.062 471472002607 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.25 471472002608 1 probable transmembrane helix predicted for CTL0536 by TMHMM2.0 at aa 9-28 471472002609 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 471472002610 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase famil, score 2.3e-19 471472002611 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 471472002612 Clp amino terminal domain; Region: Clp_N; pfam02861 471472002613 Clp amino terminal domain; Region: Clp_N; pfam02861 471472002614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471472002615 Walker A motif; other site 471472002616 ATP binding site [chemical binding]; other site 471472002617 Walker B motif; other site 471472002618 arginine finger; other site 471472002619 UvrB/uvrC motif; Region: UVR; pfam02151 471472002620 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471472002621 Walker A motif; other site 471472002622 ATP binding site [chemical binding]; other site 471472002623 Walker B motif; other site 471472002624 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 471472002625 HMMPfam hit to PF02861, Clp amino terminal domain,score 2e-18 471472002626 PS00307 Legume lectins beta-chain signature. 471472002627 HMMPfam hit to PF02861, Clp amino terminal domain,score 5.5e-18 471472002628 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 4.1e-10 471472002629 PS00017 ATP/GTP-binding site motif A (P-loop). 471472002630 HMMPfam hit to PF02151, UvrB/uvrC motif, score 2.5e-10 471472002631 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 4.8e-97 471472002632 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 0.00038 471472002633 PS00017 ATP/GTP-binding site motif A (P-loop). 471472002634 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 471472002635 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 471472002636 Ligand Binding Site [chemical binding]; other site 471472002637 HMMPfam hit to PF03054, tRNA methyl transferase,score 2.9e-224 471472002638 HMMPfam hit to PF01171, PP-loop family, score 0.016 471472002639 IncA protein; Region: IncA; pfam04156 471472002640 IncA protein; Region: IncA; pfam04156 471472002641 HMMPfam hit to PF04156, IncA protein, score 0.00057 471472002642 4 probable transmembrane helices predicted for CTL0540 by TMHMM2.0 at aa 36-58, 63-85, 240-262 and 266-288 471472002643 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472002644 2 probable transmembrane helices predicted for CTL0541 by TMHMM2.0 at aa 10-32 and 338-360 471472002645 Helix-turn-helix domain; Region: HTH_17; pfam12728 471472002646 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 471472002647 active site 471472002648 phosphorylation site [posttranslational modification] 471472002649 HMMPfam hit to PF00359,Phosphoenolpyruvate-dependent sugar phosph, score 0.00029 471472002650 PS00372 PTS EIIA domains phosphorylation site signature 2. 471472002651 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 471472002652 active site 471472002653 phosphorylation site [posttranslational modification] 471472002654 HMMPfam hit to PF00359,Phosphoenolpyruvate-dependent sugar phosph, score 9.3e-16 471472002655 PS00372 PTS EIIA domains phosphorylation site signature 2. 471472002656 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 471472002657 trimer interface [polypeptide binding]; other site 471472002658 active site 471472002659 HMMPfam hit to PF00692, dUTPase, score 8.8e-26 471472002660 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 471472002661 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 471472002662 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 471472002663 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 471472002664 HMMPfam hit to PF02777, Iron/manganese superoxide dismutases, C-term, score 5.9e-54 471472002665 PS00088 Manganese and iron superoxide dismutases signature. 471472002666 HMMPfam hit to PF00081, Iron/manganese superoxide dismutases, alpha-, score 3.8e-46 471472002667 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 471472002668 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 471472002669 active site 471472002670 substrate binding site [chemical binding]; other site 471472002671 metal binding site [ion binding]; metal-binding site 471472002672 HMMPfam hit to PF02880,Phosphoglucomutase/phosphomannomutase, al, score 0.00069 471472002673 HMMPfam hit to PF02879,Phosphoglucomutase/phosphomannomutase, al, score 0.0042 471472002674 HMMPfam hit to PF02878,Phosphoglucomutase/phosphomannomutase, al, score 1.1e-59 471472002675 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 471472002676 ribonuclease III; Reviewed; Region: rnc; PRK00102 471472002677 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 471472002678 dimerization interface [polypeptide binding]; other site 471472002679 active site 471472002680 metal binding site [ion binding]; metal-binding site 471472002681 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 471472002682 dsRNA binding site [nucleotide binding]; other site 471472002683 HMMPfam hit to PF00636, RNase3 domain, score 4.6e-43 471472002684 PS00517 Ribonuclease III family signature. 471472002685 HMMPfam hit to PF00035, Double-stranded RNA binding motif, score 4.2e-15 471472002686 DNA repair protein RadA; Provisional; Region: PRK11823 471472002687 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 471472002688 Walker A motif/ATP binding site; other site 471472002689 ATP binding site [chemical binding]; other site 471472002690 Walker B motif; other site 471472002691 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 471472002692 PS00017 ATP/GTP-binding site motif A (P-loop). 471472002693 porphobilinogen deaminase; Provisional; Region: PRK01066 471472002694 Porphobilinogen deaminase [Coenzyme metabolism]; Region: HemC; COG0181 471472002695 HMMPfam hit to PF01379, Porphobilinogen deaminase,dipyrometha, score 4.1e-17 471472002696 putative integral membrane protein (pseudogene) 471472002697 2 probable transmembrane helices predicted for CTL0552A by TMHMM2.0 at aa 30-52 and 65-87 471472002698 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 471472002699 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471472002700 active site 471472002701 ATP binding site [chemical binding]; other site 471472002702 substrate binding site [chemical binding]; other site 471472002703 activation loop (A-loop); other site 471472002704 HMMPfam hit to PF00069, Protein kinase domain,score 2.3e-44 471472002705 PS00108 Serine/Threonine protein kinases active-site signature. 471472002706 PS00107 Protein kinases ATP-binding region signature. 471472002707 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 471472002708 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 471472002709 active site 471472002710 HIGH motif; other site 471472002711 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 471472002712 KMSKS motif; other site 471472002713 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 471472002714 tRNA binding surface [nucleotide binding]; other site 471472002715 anticodon binding site; other site 471472002716 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 471472002717 HMMPfam hit to PF08264, Anticodon-binding domain,score 1.4e-24 471472002718 HMMPfam hit to PF00133, tRNA synthetases class I (I,L, M and V), score 9.5e-213 471472002719 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 471472002720 V-type ATP synthase subunit K; Provisional; Region: PRK09621 471472002721 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 471472002722 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 471472002723 4 probable transmembrane helices predicted for CTL0556 by TMHMM2.0 at aa 10-32, 45-67, 77-96 and 117-139 471472002724 HMMPfam hit to PF00137, ATP synthase subunit C,score 0.00038 471472002725 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472002726 V-type ATP synthase subunit I; Validated; Region: PRK05771 471472002727 Protein of unknown function (DUF1319); Region: DUF1319; pfam07028 471472002728 HMMPfam hit to PF01496, V-type ATPase 116kDa subunit family, score 1.2e-10 471472002729 7 probable transmembrane helices predicted for CTL0557 by TMHMM2.0 at aa 317-339, 360-382,457-479,486-508, 518-540, 561-583 and 593-615 471472002730 V-type ATP synthase subunit D; Provisional; Region: PRK02195 471472002731 HMMPfam hit to PF01813, ATP synthase subunit D,score 6.2e-79 471472002732 V-type ATP synthase subunit B; Provisional; Region: PRK02118 471472002733 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 471472002734 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 471472002735 Walker A motif homologous position; other site 471472002736 Walker B motif; other site 471472002737 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleot, score 1e-65 471472002738 HMMPfam hit to PF02874, ATP synthase alpha/beta family, beta-ba, score 2.4e-14 471472002739 V-type ATP synthase subunit A; Provisional; Region: PRK04192 471472002740 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 471472002741 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 471472002742 Walker A motif/ATP binding site; other site 471472002743 Walker B motif; other site 471472002744 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 471472002745 HMMPfam hit to PF00306, ATP synthase alpha/beta chain, C termin, score 2.7e-09 471472002746 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleot, score 3.5e-89 471472002747 PS00152 ATP synthase alpha and beta subunits signature. 471472002748 PS00017 ATP/GTP-binding site motif A (P-loop). 471472002749 HMMPfam hit to PF02874, ATP synthase alpha/beta family, beta-ba, score 2e-12 471472002750 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 471472002751 PS00017 ATP/GTP-binding site motif A (P-loop). 471472002752 V-type ATP synthase subunit E; Provisional; Region: PRK01005 471472002753 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 471472002754 HMMPfam hit to PF01991, ATP synthase (E/31 kDa) subunit, score 0.00014 471472002755 PS00652 TNFR/NGFR family cysteine-rich region signature. 471472002756 transaldolase-like protein; Provisional; Region: PTZ00411 471472002757 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 471472002758 active site 471472002759 dimer interface [polypeptide binding]; other site 471472002760 catalytic residue [active] 471472002761 HMMPfam hit to PF00923, Transaldolase, score 7.8e-121 471472002762 PS00958 Transaldolase active site. 471472002763 PS01054 Transaldolase signature 1. 471472002764 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 471472002765 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 471472002766 beta and beta' interface [polypeptide binding]; other site 471472002767 beta' and sigma factor interface [polypeptide binding]; other site 471472002768 Zn-binding [ion binding]; other site 471472002769 active site region [active] 471472002770 catalytic site [active] 471472002771 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 471472002772 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 471472002773 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 471472002774 DNA binding site [nucleotide binding] 471472002775 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 471472002776 HMMPfam hit to PF04998, RNA polymerase Rpb1,domain,score 1.2e-122 471472002777 HMMPfam hit to PF05000, RNA polymerase Rpb1,domain,score 6.9e-25 471472002778 HMMPfam hit to PF04983, RNA polymerase Rpb1,domain,score 1.5e-39 471472002779 HMMPfam hit to PF00623, RNA polymerase Rpb1,domain,score 2.4e-86 471472002780 HMMPfam hit to PF04997, RNA polymerase Rpb1,domain,score 1.4e-165 471472002781 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 471472002782 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 471472002783 RPB12 interaction site [polypeptide binding]; other site 471472002784 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 471472002785 RPB1 interaction site [polypeptide binding]; other site 471472002786 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 471472002787 RPB10 interaction site [polypeptide binding]; other site 471472002788 RPB11 interaction site [polypeptide binding]; other site 471472002789 RPB3 interaction site [polypeptide binding]; other site 471472002790 HMMPfam hit to PF04560, RNA polymerase Rpb2,domain,score 6.4e-46 471472002791 HMMPfam hit to PF00562, RNA polymerase Rpb2,domain,score 2.1e-181 471472002792 PS00017 ATP/GTP-binding site motif A (P-loop). 471472002793 PS01166 RNA polymerases beta chain signature. 471472002794 HMMPfam hit to PF04565, RNA polymerase Rpb2,domain,score 5.9e-43 471472002795 HMMPfam hit to PF04563, RNA polymerase beta subunit,score 8.6e-30 471472002796 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 471472002797 core dimer interface [polypeptide binding]; other site 471472002798 peripheral dimer interface [polypeptide binding]; other site 471472002799 L10 interface [polypeptide binding]; other site 471472002800 L11 interface [polypeptide binding]; other site 471472002801 putative EF-Tu interaction site [polypeptide binding]; other site 471472002802 putative EF-G interaction site [polypeptide binding]; other site 471472002803 HMMPfam hit to PF00542, Ribosomal protein L7/L12 C-terminal dom, score 4e-39 471472002804 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 471472002805 23S rRNA interface [nucleotide binding]; other site 471472002806 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 471472002807 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 471472002808 mRNA/rRNA interface [nucleotide binding]; other site 471472002809 HMMPfam hit to PF00687, Ribosomal protein L1p/L10e family, score 2.7e-108 471472002810 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 471472002811 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 471472002812 putative thiostrepton binding site; other site 471472002813 23S rRNA interface [nucleotide binding]; other site 471472002814 L7/L12 interface [polypeptide binding]; other site 471472002815 L25 interface [polypeptide binding]; other site 471472002816 PS00359 Ribosomal protein L11 signature. 471472002817 HMMPfam hit to PF00298, Ribosomal protein L11, RNA binding do, score 5.9e-31 471472002818 HMMPfam hit to PF03946, Ribosomal protein L11,N-terminal dom, score 5.3e-31 471472002819 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 471472002820 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 471472002821 putative homodimer interface [polypeptide binding]; other site 471472002822 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 471472002823 heterodimer interface [polypeptide binding]; other site 471472002824 homodimer interface [polypeptide binding]; other site 471472002825 HMMPfam hit to PF00467, KOW motif, score 5.2e-08 471472002826 HMMPfam hit to PF02357, Transcription termination factor nusG, score 2.8e-37 471472002827 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 471472002828 1 probable transmembrane helix predicted for CTL0573 by TMHMM2.0 at aa 47-66 471472002829 elongation factor Tu; Reviewed; Region: PRK12735 471472002830 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 471472002831 G1 box; other site 471472002832 GEF interaction site [polypeptide binding]; other site 471472002833 GTP/Mg2+ binding site [chemical binding]; other site 471472002834 Switch I region; other site 471472002835 G2 box; other site 471472002836 G3 box; other site 471472002837 Switch II region; other site 471472002838 G4 box; other site 471472002839 G5 box; other site 471472002840 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 471472002841 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 471472002842 Antibiotic Binding Site [chemical binding]; other site 471472002843 HMMPfam hit to PF03143, Elongation factor Tu C-terminal domain, score 2e-57 471472002844 HMMPfam hit to PF03144, Elongation factor Tu domain,score 2.7e-25 471472002845 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 4.7e-96 471472002846 PS00301 GTP-binding elongation factors signature. 471472002847 PS00017 ATP/GTP-binding site motif A (P-loop). 471472002848 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 471472002849 rRNA binding site [nucleotide binding]; other site 471472002850 predicted 30S ribosome binding site; other site 471472002851 HMMPfam hit to PF00575, S1 RNA binding domain,score 1.2e-05 471472002852 HMMPfam hit to PF01176, Translation initiation factor 1A / IF-1, score 3.6e-26 471472002853 Colicin pore forming domain; Region: Colicin; pfam01024 471472002854 3 probable transmembrane helices predicted for CTL0576 by TMHMM2.0 at aa 76-93, 97-119 and 150-172 471472002855 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 471472002856 HMMPfam hit to PF02657, Fe-S metabolism associated domain, score 1.2e-67 471472002857 conserved hypothetical protein (pseudogene) 471472002858 HMMPfam hit to PF05095, Protein of unknown function (DUF687), score 0 471472002859 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 471472002860 active site 471472002861 HMMPfam hit to PF00697,N-(5'phosphoribosyl)anthranilate (PRA) isome, score 2.6e-26 471472002862 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 471472002863 substrate binding site [chemical binding]; other site 471472002864 dimer interface [polypeptide binding]; other site 471472002865 catalytic triad [active] 471472002866 HMMPfam hit to PF00121, Triosephosphate isomerase,score 3e-141 471472002867 PS00171 Triosephosphate isomerase active site. 471472002868 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 471472002869 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 471472002870 generic binding surface II; other site 471472002871 generic binding surface I; other site 471472002872 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 8.3e-08 471472002873 HMMPfam hit to PF02601, Exonuclease VII, large subunit, score 3.7e-152 471472002874 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 471472002875 HMMPfam hit to PF02609, Exonuclease VII small subunit, score 3.1e-08 471472002876 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 471472002877 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 471472002878 TPP-binding site; other site 471472002879 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471472002880 PYR/PP interface [polypeptide binding]; other site 471472002881 dimer interface [polypeptide binding]; other site 471472002882 TPP binding site [chemical binding]; other site 471472002883 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471472002884 PS00801 Transketolase signature 1. 471472002885 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 3.8e-50 471472002886 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 5.6e-44 471472002887 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 471472002888 pyruvate kinase; Region: pyruv_kin; TIGR01064 471472002889 domain interfaces; other site 471472002890 active site 471472002891 HMMPfam hit to PF00224, Pyruvate kinase, barrel domain, score 1.1e-137 471472002892 HMMPfam hit to PF02887, Pyruvate kinase, alpha/beta domain, score 5.9e-13 471472002893 excinuclease ABC subunit A; Provisional; Region: PRK00635 471472002894 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471472002895 Walker A/P-loop; other site 471472002896 ATP binding site [chemical binding]; other site 471472002897 Q-loop/lid; other site 471472002898 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471472002899 ABC transporter signature motif; other site 471472002900 Walker B; other site 471472002901 D-loop; other site 471472002902 H-loop/switch region; other site 471472002903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471472002904 Walker A/P-loop; other site 471472002905 ATP binding site [chemical binding]; other site 471472002906 Q-loop/lid; other site 471472002907 ABC transporter signature motif; other site 471472002908 Walker B; other site 471472002909 D-loop; other site 471472002910 H-loop/switch region; other site 471472002911 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471472002912 Walker A/P-loop; other site 471472002913 ATP binding site [chemical binding]; other site 471472002914 Q-loop/lid; other site 471472002915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471472002916 ABC transporter signature motif; other site 471472002917 Walker B; other site 471472002918 D-loop; other site 471472002919 H-loop/switch region; other site 471472002920 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471472002921 Walker A/P-loop; other site 471472002922 ATP binding site [chemical binding]; other site 471472002923 Q-loop/lid; other site 471472002924 ABC transporter signature motif; other site 471472002925 Walker B; other site 471472002926 D-loop; other site 471472002927 H-loop/switch region; other site 471472002928 HMMPfam hit to PF00005, ABC transporter, score 1.1e-08 471472002929 PS00017 ATP/GTP-binding site motif A (P-loop). 471472002930 PS00017 ATP/GTP-binding site motif A (P-loop). 471472002931 HMMPfam hit to PF00005, ABC transporter, score 7.8e-13 471472002932 PS00017 ATP/GTP-binding site motif A (P-loop). 471472002933 PS00017 ATP/GTP-binding site motif A (P-loop). 471472002934 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 471472002935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471472002936 Walker A motif; other site 471472002937 ATP binding site [chemical binding]; other site 471472002938 Walker B motif; other site 471472002939 arginine finger; other site 471472002940 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 5.5e-07 471472002941 PS00017 ATP/GTP-binding site motif A (P-loop). 471472002942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0718 471472002943 HMMPfam hit to PF02575, Uncharacterised BCR, YbaB family COG0718, score 1.6e-38 471472002944 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 471472002945 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 471472002946 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 471472002947 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 471472002948 HMMPfam hit to PF02896, PEP-utilising enzyme, TIM barrel doma, score 7.9e-37 471472002949 HMMPfam hit to PF00391, PEP-utilising enzyme,mobile domain, score 2.5e-20 471472002950 HMMPfam hit to PF05524, PEP-utilising enzyme,N-terminal, score 1.3e-13 471472002951 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 471472002952 dimerization domain swap beta strand [polypeptide binding]; other site 471472002953 regulatory protein interface [polypeptide binding]; other site 471472002954 active site 471472002955 regulatory phosphorylation site [posttranslational modification]; other site 471472002956 HMMPfam hit to PF00381, PTS HPr component phosphorylation site, score 1.2e-16 471472002957 PS00589 PTS HPR component serine phosphorylation site signature. 471472002958 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 471472002959 Competence protein; Region: Competence; pfam03772 471472002960 9 probable transmembrane helices predicted for CTL0593 by TMHMM2.0 at aa 42-64, 76-93, 254-276,283-302,317-339, 346-368, 381-403, 416-438 and 474-496 471472002961 HMMPfam hit to PF03772, Competence protein, score 4.5e-59 471472002962 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 471472002963 tetramer interface [polypeptide binding]; other site 471472002964 TPP-binding site [chemical binding]; other site 471472002965 heterodimer interface [polypeptide binding]; other site 471472002966 phosphorylation loop region [posttranslational modification] 471472002967 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 471472002968 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 471472002969 alpha subunit interface [polypeptide binding]; other site 471472002970 TPP binding site [chemical binding]; other site 471472002971 heterodimer interface [polypeptide binding]; other site 471472002972 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471472002973 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 2.8e-56 471472002974 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 8e-74 471472002975 HMMPfam hit to PF00676, Dehydrogenase E1 component,score 1.4e-29 471472002976 PS00017 ATP/GTP-binding site motif A (P-loop). 471472002977 chaperone protein DnaJ; Provisional; Region: PRK14284 471472002978 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 471472002979 HSP70 interaction site [polypeptide binding]; other site 471472002980 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 471472002981 Zn binding sites [ion binding]; other site 471472002982 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 471472002983 dimer interface [polypeptide binding]; other site 471472002984 HMMPfam hit to PF01556, DnaJ C terminal region,score 9.6e-54 471472002985 HMMPfam hit to PF00684, DnaJ central domain (4 repeats), score 1.6e-23 471472002986 HMMPfam hit to PF00226, DnaJ domain, score 4.6e-40 471472002987 PS00636 Nt-dnaJ domain signature. 471472002988 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 471472002989 HMMPfam hit to PF01165, Ribosomal protein S21,score 9e-11 471472002990 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 471472002991 Glycoprotease family; Region: Peptidase_M22; pfam00814 471472002992 HMMPfam hit to PF00814, Glycoprotease family, score 3.4e-05 471472002993 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 471472002994 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 471472002995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471472002996 Walker A motif; other site 471472002997 ATP binding site [chemical binding]; other site 471472002998 Walker B motif; other site 471472002999 arginine finger; other site 471472003000 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 471472003001 HMMPfam hit to PF02190, ATP-dependent protease La (LON) domain, score 1.6e-16 471472003002 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 2.2e-48 471472003003 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 3.2e-05 471472003004 PS00017 ATP/GTP-binding site motif A (P-loop). 471472003005 HMMPfam hit to PF05362, Lon protease (S16) C-terminal proteolytic do, score 1.3e-107 471472003006 PS01046 ATP-dependent serine proteases, lon family,serine active site. 471472003007 2 probable transmembrane helices predicted for CTL0599 by TMHMM2.0 at aa 31-53 and 57-79 471472003008 ribonuclease Z; Region: RNase_Z; TIGR02651 471472003009 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 3.5e-10 471472003010 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 471472003011 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471472003012 active site 471472003013 DNA binding site [nucleotide binding] 471472003014 Int/Topo IB signature motif; other site 471472003015 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 8.7e-05 471472003016 HMMPfam hit to PF00589, Phage integrase family,score 1.9e-44 471472003017 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471472003018 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471472003019 ABC transporter; Region: ABC_tran_2; pfam12848 471472003020 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471472003021 HMMPfam hit to PF00005, ABC transporter, score 1.2e-32 471472003022 PS00017 ATP/GTP-binding site motif A (P-loop). 471472003023 HMMPfam hit to PF00005, ABC transporter, score 9.9e-37 471472003024 PS00017 ATP/GTP-binding site motif A (P-loop). 471472003025 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 471472003026 active site 471472003027 dimer interface [polypeptide binding]; other site 471472003028 HMMPfam hit to PF02545, Maf-like protein, score 1.4e-107 471472003029 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 471472003030 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472003031 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 471472003032 2 probable transmembrane helices predicted for CTL0606 by TMHMM2.0 at aa 3-25 and 57-79 471472003033 HMMPfam hit to PF03840, Preprotein translocase SecG subunit, score 6.9e-24 471472003034 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 471472003035 active site 471472003036 catalytic residues [active] 471472003037 metal binding site [ion binding]; metal-binding site 471472003038 HMMPfam hit to PF01327, Polypeptide deformylase,score 6.2e-51 471472003039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471472003040 S-adenosylmethionine binding site [chemical binding]; other site 471472003041 HMMPfam hit to PF00398, Ribosomal RNA adenine dimethylase, score 5.6e-56 471472003042 PS01131 Ribosomal RNA adenine dimethylases signature. 471472003043 1 probable transmembrane helix predicted for CTL0609 by TMHMM2.0 at aa 7-29 471472003044 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 471472003045 Protein of unknown function, DUF255; Region: Thioredox_DsbH; pfam03190 471472003046 PS00336 Beta-lactamase class-C active site. 471472003047 HMMPfam hit to PF03190, Protein of unknown function,DUF255, score 7.6e-48 471472003048 2 probable transmembrane helices predicted for CTL0611A by TMHMM2.0 at aa 37-59 and 64-86 471472003049 2 probable transmembrane helices predicted for CTL0612 by TMHMM2.0 at aa 45-67 and 77-99 471472003050 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 471472003051 HMMPfam hit to PF02632, BioY family, score 1.5e-70 471472003052 5 probable transmembrane helices predicted for CTL0613 by TMHMM2.0 at aa 22-44, 51-73, 88-113, 125-147 and 162-184 471472003053 PS00011 Vitamin K-dependent carboxylation domain. 471472003054 Class I aldolases; Region: Aldolase_Class_I; cl17187 471472003055 catalytic residue [active] 471472003056 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase family, score 2.2e-15 471472003057 PS00665 Dihydrodipicolinate synthetase signature 1. 471472003058 aspartate kinase; Provisional; Region: PRK05925 471472003059 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 471472003060 putative catalytic residues [active] 471472003061 nucleotide binding site [chemical binding]; other site 471472003062 aspartate binding site [chemical binding]; other site 471472003063 HMMPfam hit to PF00696, Amino acid kinase family,score 1.8e-54 471472003064 PS00017 ATP/GTP-binding site motif A (P-loop). 471472003065 PS00324 Aspartokinase signature. 471472003066 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 471472003067 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 471472003068 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 471472003069 HMMPfam hit to PF02774, Semialdehyde dehydrogenase,dimerisat, score 7.1e-20 471472003070 HMMPfam hit to PF01118, Semialdehyde dehydrogenase,NAD bindi, score 7.8e-36 471472003071 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 471472003072 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 471472003073 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 471472003074 HMMPfam hit to PF05173, Dihydrodipicolinate reductase, C-terminus, score 1.8e-57 471472003075 HMMPfam hit to PF01113, Dihydrodipicolinate reductase, N-terminus, score 1.1e-29 471472003076 10 probable transmembrane helices predicted for CTL0619 by TMHMM2.0 at aa 55-77, 83-105, 125-147,162-179,212-234, 238-260, 338-360, 370-392, 469-491 and 495-517 471472003077 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 471472003078 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 471472003079 hinge; other site 471472003080 active site 471472003081 HMMPfam hit to PF00275, EPSP synthase (3-phosphoshikimate 1-car, score 1.2e-75 471472003082 PS00885 EPSP synthase signature 2. 471472003083 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 471472003084 shikimate kinase; Provisional; Region: PRK00625 471472003085 active site 471472003086 PS00017 ATP/GTP-binding site motif A (P-loop). 471472003087 HMMPfam hit to PF01202, Shikimate kinase, score 2.3e-32 471472003088 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 471472003089 Tetramer interface [polypeptide binding]; other site 471472003090 active site 471472003091 FMN-binding site [chemical binding]; other site 471472003092 HMMPfam hit to PF01264, Chorismate synthase, score 3e-126 471472003093 PS00787 Chorismate synthase signature 1. 471472003094 PS00788 Chorismate synthase signature 2. 471472003095 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 471472003096 active site 471472003097 dimer interface [polypeptide binding]; other site 471472003098 metal binding site [ion binding]; metal-binding site 471472003099 HMMPfam hit to PF01761, 3-dehydroquinate synthase,score 1.5e-124 471472003100 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310 471472003101 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 471472003102 active site 471472003103 catalytic residue [active] 471472003104 dimer interface [polypeptide binding]; other site 471472003105 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 471472003106 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 471472003107 shikimate binding site; other site 471472003108 NAD(P) binding site [chemical binding]; other site 471472003109 HMMPfam hit to PF01487, Type I 3-dehydroquinase,score 6.7e-77 471472003110 HMMPfam hit to PF08501, Shikimate dehydrogenase substrate bind, score 2.1e-16 471472003111 HMMPfam hit to PF01488, Shikimate / quinate 5-dehydrogenase, score 7.2e-08 471472003112 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 471472003113 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 471472003114 HMMPfam hit to PF04966, Carbohydrate-selective porin, OprB family, score 2e-31 471472003115 pyruvoyl-dependent arginine decarboxylase (pseudogene) 471472003116 HMMPfam hit to PF01862, Pyruvoyl-dependent arginine decarboxylase (P, score 1.7e-84 471472003117 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 471472003118 13 probable transmembrane helices predicted for CTL0628 by TMHMM2.0 at aa 11-33, 48-70, 90-112,127-149,156-178, 209-228, 241-263, 293-315, 335-357,367-389,402-419, 423-445 and 458-477 471472003119 HMMPfam hit to PF00324, Amino acid permease, score 3.2e-07 471472003120 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 471472003121 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 471472003122 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 471472003123 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 471472003124 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 6.1e-54 471472003125 malate dehydrogenase; Provisional; Region: PRK05442 471472003126 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 471472003127 NAD(P) binding site [chemical binding]; other site 471472003128 LDH/MDH dimer interface [polypeptide binding]; other site 471472003129 substrate binding site [chemical binding]; other site 471472003130 HMMPfam hit to PF02866, lactate/malate dehydrogenase, alpha/beta C-t, score 1.3e-28 471472003131 HMMPfam hit to PF00056, lactate/malate dehydrogenase, NAD binding do, score 3e-36 471472003132 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 471472003133 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 471472003134 active site 471472003135 dimer interface [polypeptide binding]; other site 471472003136 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 471472003137 dimer interface [polypeptide binding]; other site 471472003138 active site 471472003139 HMMPfam hit to PF00342, Phosphoglucose isomerase,score 1.6e-116 471472003140 PS00017 ATP/GTP-binding site motif A (P-loop). 471472003141 GTPases [General function prediction only]; Region: HflX; COG2262 471472003142 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 471472003143 HflX GTPase family; Region: HflX; cd01878 471472003144 G1 box; other site 471472003145 GTP/Mg2+ binding site [chemical binding]; other site 471472003146 Switch I region; other site 471472003147 G2 box; other site 471472003148 G3 box; other site 471472003149 Switch II region; other site 471472003150 G4 box; other site 471472003151 G5 box; other site 471472003152 HMMPfam hit to PF01926, GTPase of unknown function,score 1.2e-37 471472003153 PS00017 ATP/GTP-binding site motif A (P-loop). 471472003154 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 471472003155 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 7.9e-15 471472003156 PS00022 EGF-like domain signature 1. 471472003157 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 471472003158 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471472003159 substrate binding pocket [chemical binding]; other site 471472003160 membrane-bound complex binding site; other site 471472003161 hinge residues; other site 471472003162 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 1e-32 471472003163 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 471472003164 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 471472003165 HMMPfam hit to PF00793, DAHP synthetase I family,score 3.1e-121 471472003166 2 probable transmembrane helices predicted for CTL0639 by TMHMM2.0 at aa 106-128 and 133-155 471472003167 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 471472003168 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 471472003169 nucleotide binding site/active site [active] 471472003170 HMMPfam hit to PF01230, HIT domain, score 7.9e-35 471472003171 PS00892 HIT family signature. 471472003172 Uncharacterized conserved protein related to MYG1 family [Function unknown]; Region: COG4286 471472003173 HMMPfam hit to PF03690, Uncharacterised protein family (UPF0160), score 1.1e-180 471472003174 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 471472003175 hypothetical protein; Validated; Region: PRK00647 471472003176 HMMPfam hit to PF02594, Uncharacterised ACR, YggU family COG1872, score 1.6e-32 471472003177 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 471472003178 1 probable transmembrane helix predicted for CTL0645 by TMHMM2.0 at aa 7-24 471472003179 HMMPfam hit to PF06727, Protein of unknown function (DUF1207), score 6.7e-295 471472003180 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 471472003181 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471472003182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471472003183 homodimer interface [polypeptide binding]; other site 471472003184 catalytic residue [active] 471472003185 HMMPfam hit to PF00155, Aminotransferase class I and II, score 1.5e-32 471472003186 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 471472003187 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG2984 471472003188 1 probable transmembrane helix predicted for CTL0647 by TMHMM2.0 at aa 7-29 471472003189 HMMPfam hit to PF04392, ABC transporter substrate binding protei, score 3.6e-132 471472003190 prolyl-tRNA synthetase; Provisional; Region: PRK09194 471472003191 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 471472003192 dimer interface [polypeptide binding]; other site 471472003193 motif 1; other site 471472003194 active site 471472003195 motif 2; other site 471472003196 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 471472003197 putative deacylase active site [active] 471472003198 motif 3; other site 471472003199 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 471472003200 anticodon binding site; other site 471472003201 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 1e-51 471472003202 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 471472003203 PS00017 ATP/GTP-binding site motif A (P-loop). 471472003204 HMMPfam hit to PF04073, YbaK / prolyl-tRNA synthetases associa, score 7.6e-05 471472003205 HMMPfam hit to PF03129, Anticodon binding domain,score 2.9e-20 471472003206 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 471472003207 HrcA protein C terminal domain; Region: HrcA; pfam01628 471472003208 HMMPfam hit to PF01628, HrcA protein C terminal domain, score 3.3e-76 471472003209 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 471472003210 dimer interface [polypeptide binding]; other site 471472003211 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 471472003212 HMMPfam hit to PF01025, GrpE, score 5.3e-72 471472003213 PS01071 grpE protein signature. 471472003214 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 471472003215 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 471472003216 nucleotide binding site [chemical binding]; other site 471472003217 NEF interaction site [polypeptide binding]; other site 471472003218 SBD interface [polypeptide binding]; other site 471472003219 PS00297 Heat shock hsp70 proteins family signature 1. 471472003220 PS00329 Heat shock hsp70 proteins family signature 2. 471472003221 PS01036 Heat shock hsp70 proteins family signature 3. 471472003222 Exoribonuclease R [Transcription]; Region: VacB; COG0557 471472003223 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 471472003224 RNB domain; Region: RNB; pfam00773 471472003225 HMMPfam hit to PF00773, RNB-like protein, score 2.1e-123 471472003226 PS01175 Ribonuclease II family signature. 471472003227 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 471472003228 Putative zinc ribbon domain; Region: DUF164; pfam02591 471472003229 HMMPfam hit to PF02591, Uncharacterized ACR,COG1579,score 2.2e-129 471472003230 KpsF/GutQ family protein; Region: kpsF; TIGR00393 471472003231 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 471472003232 putative active site [active] 471472003233 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 471472003234 HMMPfam hit to PF00571, CBS domain pair, score 3.6e-16 471472003235 HMMPfam hit to PF01380, SIS domain, score 1.2e-19 471472003236 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 471472003237 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471472003238 E3 interaction surface; other site 471472003239 lipoyl attachment site [posttranslational modification]; other site 471472003240 e3 binding domain; Region: E3_binding; pfam02817 471472003241 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 471472003242 HMMPfam hit to PF00198, 2-oxoacid dehydrogenases acyltransferas, score 2.6e-110 471472003243 HMMPfam hit to PF02817, e3 binding domain, score 1.5e-13 471472003244 HMMPfam hit to PF00364, Biotin-requiring enzyme,score 3.1e-18 471472003245 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 471472003246 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 471472003247 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 8.5e-107 471472003248 8 probable transmembrane helices predicted for CTL0658 by TMHMM2.0 at aa 7-21, 36-58, 71-93,136-158,179-198, 213-235, 312-334 and 344-366 471472003249 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 471472003250 HMMPfam hit to PF02606, Tetraacyldisaccharide-1-P 4'-kinase, score 4.3e-222 471472003251 PS00136 Serine proteases, subtilase family,aspartic acid active site. 471472003252 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471472003253 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 471472003254 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 471472003255 HMMPfam hit to PF00588, SpoU rRNA Methylase family,score 6.1e-45 471472003256 HMMPfam hit to PF08032, RNA 2'-O ribose methyltransferase subs, score 7.7e-13 471472003257 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 471472003258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471472003259 S-adenosylmethionine binding site [chemical binding]; other site 471472003260 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 471472003261 Lumazine binding domain; Region: Lum_binding; pfam00677 471472003262 Lumazine binding domain; Region: Lum_binding; pfam00677 471472003263 HMMPfam hit to PF00677, Lumazine binding domain,score 5.4e-26 471472003264 HMMPfam hit to PF00677, Lumazine binding domain,score 2.7e-13 471472003265 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 471472003266 ATP cone domain; Region: ATP-cone; pfam03477 471472003267 HMMPfam hit to PF03477, ATP cone domain, score 1.1e-29 471472003268 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 471472003269 HMMPfam hit to PF01258, Prokaryotic dksA/traR C4-type zinc finge, score 1.7e-07 471472003270 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 471472003271 5 probable transmembrane helices predicted for CTL0665 by TMHMM2.0 at aa 5-27, 40-62, 66-88, 101-123 and 138-160 471472003272 HMMPfam hit to PF01252, Signal peptidase (SPase) II,score 5.5e-16 471472003273 amino acid carrier protein; Region: agcS; TIGR00835 471472003274 11 probable transmembrane helices predicted for CTL0666 by TMHMM2.0 at aa 15-32, 70-92, 102-124,151-173,186-203, 210-232, 242-264, 303-325, 350-372,385-402 and 407-429 471472003275 HMMPfam hit to PF01235, Sodium:alanine symporter family, score 1.2e-16 471472003276 poly(A) polymerase; Region: pcnB; TIGR01942 471472003277 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 471472003278 active site 471472003279 NTP binding site [chemical binding]; other site 471472003280 metal binding triad [ion binding]; metal-binding site 471472003281 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 471472003282 HMMPfam hit to PF01743, Poly A polymerase family,score 7.9e-72 471472003283 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK01021 471472003284 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 471472003285 Predicted membrane protein [Function unknown]; Region: COG3952 471472003286 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 471472003287 6 probable transmembrane helices predicted for CTL0668 by TMHMM2.0 at aa 10-32, 39-61, 65-82,95-117,137-156 and 168-190 471472003288 HMMPfam hit to PF07578, Lipid A Biosynthesis N-terminal domain, score 9.7e-38 471472003289 HMMPfam hit to PF07578, Lipid A Biosynthesis N-terminal domain, score 6.6e-39 471472003290 HMMPfam hit to PF02684, Lipid-A-disaccharide synthetase, score 2e-227 471472003291 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 471472003292 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 471472003293 Autotransporter beta-domain; Region: Autotransporter; pfam03797 471472003294 1 probable transmembrane helix predicted for CTL0669 by TMHMM2.0 at aa 24-46 471472003295 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 3.5 471472003296 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.01 471472003297 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.0052 471472003298 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.26 471472003299 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.0052 471472003300 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.11 471472003301 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.13 471472003302 HMMPfam hit to PF07548, Chlamydia polymorphic membrane protei, score 1.4e-55 471472003303 HMMPfam hit to PF03797, Autotransporter beta-domain,score 1.2e-40 471472003304 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 471472003305 Autotransporter beta-domain; Region: Autotransporter; pfam03797 471472003306 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.3 471472003307 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.34 471472003308 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 2.2 471472003309 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 1.4 471472003310 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.066 471472003311 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 2.1 471472003312 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 44 471472003313 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 9.5 471472003314 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.39 471472003315 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 4.5 471472003316 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.42 471472003317 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 8 471472003318 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.021 471472003319 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.98 471472003320 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 4.6 471472003321 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.65 471472003322 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.034 471472003323 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 12 471472003324 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 4.1 471472003325 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 44 471472003326 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 13 471472003327 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 2 471472003328 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.74 471472003329 HMMPfam hit to PF07548, Chlamydia polymorphic membrane protei, score 1.7e-54 471472003330 HMMPfam hit to PF03797, Autotransporter beta-domain,score 4.3e-40 471472003331 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 471472003332 Autotransporter beta-domain; Region: Autotransporter; pfam03797 471472003333 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 42 471472003334 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 9.7 471472003335 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.33 471472003336 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 46 471472003337 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.95 471472003338 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 10 471472003339 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.041 471472003340 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.04 471472003341 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.039 471472003342 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 2 471472003343 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 36 471472003344 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.31 471472003345 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.19 471472003346 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.62 471472003347 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 9.5 471472003348 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.35 471472003349 HMMPfam hit to PF07548, Chlamydia polymorphic membrane protei, score 1.5e-51 471472003350 HMMPfam hit to PF03797, Autotransporter beta-domain,score 9e-40 471472003351 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 471472003352 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471472003353 intersubunit interface [polypeptide binding]; other site 471472003354 HMMPfam hit to PF01297, Periplasmic solute binding protein family, score 8.4e-116 471472003355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471472003356 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471472003357 Walker A/P-loop; other site 471472003358 ATP binding site [chemical binding]; other site 471472003359 Q-loop/lid; other site 471472003360 ABC transporter signature motif; other site 471472003361 Walker B; other site 471472003362 D-loop; other site 471472003363 H-loop/switch region; other site 471472003364 HMMPfam hit to PF00005, ABC transporter, score 8.4e-42 471472003365 PS00017 ATP/GTP-binding site motif A (P-loop). 471472003366 PS00211 ABC transporters family signature. 471472003367 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471472003368 ABC-ATPase subunit interface; other site 471472003369 dimer interface [polypeptide binding]; other site 471472003370 putative PBP binding regions; other site 471472003371 HMMPfam hit to PF00950, ABC 3 transport family,score 1.1e-57 471472003372 8 probable transmembrane helices predicted for CTL0674 by TMHMM2.0 at aa 15-37, 44-66, 70-92,101-123,143-165, 186-208, 228-250 and 255-277 471472003373 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 471472003374 GTP1/OBG; Region: GTP1_OBG; pfam01018 471472003375 Obg GTPase; Region: Obg; cd01898 471472003376 G1 box; other site 471472003377 GTP/Mg2+ binding site [chemical binding]; other site 471472003378 Switch I region; other site 471472003379 G2 box; other site 471472003380 G3 box; other site 471472003381 Switch II region; other site 471472003382 G4 box; other site 471472003383 G5 box; other site 471472003384 HMMPfam hit to PF01926, GTPase of unknown function,score 1.8e-39 471472003385 PS00017 ATP/GTP-binding site motif A (P-loop). 471472003386 HMMPfam hit to PF01018, GTP1/OBG, score 1.4e-66 471472003387 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 471472003388 HMMPfam hit to PF01016, Ribosomal L27 protein,score 1.4e-40 471472003389 Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]; Region: RplU; COG0261 471472003390 HMMPfam hit to PF00829, Ribosomal prokaryotic L21 protein, score 1.3e-43 471472003391 Uncharacterized conserved protein [Function unknown]; Region: COG2928 471472003392 2 probable transmembrane helices predicted for CTL0678 by TMHMM2.0 at aa 23-45 and 78-100 471472003393 HMMPfam hit to PF04367, Protein of unknown function (DUF502), score 4.3e-89 471472003394 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 471472003395 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 471472003396 HMMPfam hit to PF02130, Uncharacterized protein family UPF0054, score 0.0012 471472003397 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471472003398 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471472003399 Transporter associated domain; Region: CorC_HlyC; smart01091 471472003400 3 probable transmembrane helices predicted for CTL0682 by TMHMM2.0 at aa 2-19, 42-64 and 71-93 471472003401 HMMPfam hit to PF00571, CBS domain pair, score 6.7e-20 471472003402 HMMPfam hit to PF03471, Transporter associated domain, score 7.8e-22 471472003403 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471472003404 anti sigma factor interaction site; other site 471472003405 regulatory phosphorylation site [posttranslational modification]; other site 471472003406 HMMPfam hit to PF01740, STAS domain, score 6e-30 471472003407 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 471472003408 hypothetical protein; Provisional; Region: PRK05926 471472003409 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471472003410 FeS/SAM binding site; other site 471472003411 HMMPfam hit to PF04055, Radical SAM superfamily,score 3.3e-16 471472003412 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 471472003413 HMMPfam hit to PF02621, Uncharacterized ACR,COG1427,score 4.8e-161 471472003414 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 471472003415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471472003416 S-adenosylmethionine binding site [chemical binding]; other site 471472003417 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 471472003418 HMMPfam hit to PF01209, ubiE/COQ5 methyltransferase family, score 2.3e-15 471472003419 HMMPfam hit to PF08241, Methyltransferase domain,score 1.1e-22 471472003420 HMMPfam hit to PF08242, Methyltransferase domain,score 1.7e-09 471472003421 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 471472003422 HMMPfam hit to PF03682, Uncharacterised protein family (UPF0158), score 9e-120 471472003423 diaminopimelate epimerase; Region: DapF; TIGR00652 471472003424 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 471472003425 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 471472003426 HMMPfam hit to PF01678, Diaminopimelate epimerase,score 1.5e-09 471472003427 HMMPfam hit to PF01678, Diaminopimelate epimerase,score 2.5e-05 471472003428 PS01326 Diaminopimelate epimerase signature. 471472003429 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471472003430 oligomer interface [polypeptide binding]; other site 471472003431 active site residues [active] 471472003432 HMMPfam hit to PF00574, Clp protease, score 1.2e-89 471472003433 PS00382 Endopeptidase Clp histidine active site. 471472003434 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 471472003435 dimer interface [polypeptide binding]; other site 471472003436 active site 471472003437 glycine-pyridoxal phosphate binding site [chemical binding]; other site 471472003438 folate binding site [chemical binding]; other site 471472003439 HMMPfam hit to PF00464, Serine hydroxymethyltransferase, score 2.9e-138 471472003440 PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 471472003441 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 471472003442 active site 471472003443 HMMPfam hit to PF02602, Uroporphyrinogen-III synthase HemD, score 2.5e-61 471472003444 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 471472003445 homotrimer interaction site [polypeptide binding]; other site 471472003446 zinc binding site [ion binding]; other site 471472003447 CDP-binding sites; other site 471472003448 HMMPfam hit to PF02542, YgbB family, score 2.6e-89 471472003449 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 471472003450 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 471472003451 FAD binding pocket [chemical binding]; other site 471472003452 conserved FAD binding motif [chemical binding]; other site 471472003453 phosphate binding motif [ion binding]; other site 471472003454 beta-alpha-beta structure motif; other site 471472003455 NAD binding pocket [chemical binding]; other site 471472003456 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 1.2e-13 471472003457 HMMPfam hit to PF00667, FAD binding domain, score 1.7e-07 471472003458 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 471472003459 HMMPfam hit to PF00338, Ribosomal protein S10p/S20e,score 3e-58 471472003460 PS00361 Ribosomal protein S10 signature. 471472003461 elongation factor G; Reviewed; Region: PRK12739 471472003462 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 471472003463 G1 box; other site 471472003464 putative GEF interaction site [polypeptide binding]; other site 471472003465 GTP/Mg2+ binding site [chemical binding]; other site 471472003466 Switch I region; other site 471472003467 G2 box; other site 471472003468 G3 box; other site 471472003469 Switch II region; other site 471472003470 G4 box; other site 471472003471 G5 box; other site 471472003472 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 471472003473 Elongation Factor G, domain II; Region: EFG_II; pfam14492 471472003474 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 471472003475 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 471472003476 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 1.8e-44 471472003477 HMMPfam hit to PF03764, Elongation factor G, domain IV, score 6.9e-66 471472003478 HMMPfam hit to PF03144, Elongation factor Tu domain,score 2.1e-18 471472003479 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 1.2e-107 471472003480 PS00301 GTP-binding elongation factors signature. 471472003481 PS00017 ATP/GTP-binding site motif A (P-loop). 471472003482 30S ribosomal protein S7; Validated; Region: PRK05302 471472003483 HMMPfam hit to PF00177, Ribosomal protein S7p/S5e,score 1.5e-95 471472003484 PS00052 Ribosomal protein S7 signature. 471472003485 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 471472003486 S17 interaction site [polypeptide binding]; other site 471472003487 S8 interaction site; other site 471472003488 16S rRNA interaction site [nucleotide binding]; other site 471472003489 streptomycin interaction site [chemical binding]; other site 471472003490 23S rRNA interaction site [nucleotide binding]; other site 471472003491 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 471472003492 HMMPfam hit to PF00164, Ribosomal protein S12,score 5e-70 471472003493 PS00055 Ribosomal protein S12 signature. 471472003494 2 probable transmembrane helices predicted for CTL0699 by TMHMM2.0 at aa 31-53 and 63-85 471472003495 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 471472003496 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 471472003497 protein binding site [polypeptide binding]; other site 471472003498 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 471472003499 Catalytic dyad [active] 471472003500 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 471472003501 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 2e-13 471472003502 HMMPfam hit to PF03572, Peptidase family S41, score 2.4e-57 471472003503 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA); Region: CRPA; pfam05745 471472003504 HMMPfam hit to PF05745, Chlamydia 15 kDa cysteine-rich outer membran, score 9.3e-81 471472003505 2 probable transmembrane helices predicted for CTL0701 by TMHMM2.0 at aa 43-65 and 69-88 471472003506 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 471472003507 Domain of unknown function DUF11; Region: DUF11; pfam01345 471472003508 Domain of unknown function DUF11; Region: DUF11; pfam01345 471472003509 HMMPfam hit to PF01345, Domain of unknown function DUF11, score 3.5e-18 471472003510 HMMPfam hit to PF01345, Domain of unknown function DUF11, score 1.4e-17 471472003511 HMMPfam hit to PF03504, Chlamydia cysteine-rich outer membrane pro, score 1.4e-78 471472003512 1 probable transmembrane helix predicted for CTL0702 by TMHMM2.0 at aa 13-32 471472003513 Chlamydia cysteine-rich outer membrane protein 3; Region: Chlam_OMP3; pfam03503 471472003514 HMMPfam hit to PF03503, Chlamydia cysteine-rich outer membrane pro, score 1.1e-32 471472003515 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472003516 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472003517 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 471472003518 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 471472003519 active site 471472003520 HIGH motif; other site 471472003521 KMSKS motif; other site 471472003522 HMMPfam hit to PF00749, tRNA synthetases class I (E and Q), cata, score 3.9e-157 471472003523 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 471472003524 Helix-turn-helix domain; Region: HTH_17; pfam12728 471472003525 Helix-turn-helix domain; Region: HTH_17; pfam12728 471472003526 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 471472003527 DHH family; Region: DHH; pfam01368 471472003528 DHHA1 domain; Region: DHHA1; pfam02272 471472003529 HMMPfam hit to PF02272, DHHA1 domain, score 1.1e-13 471472003530 HMMPfam hit to PF01368, DHH family, score 4.8e-43 471472003531 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 471472003532 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 471472003533 Protein export membrane protein; Region: SecD_SecF; pfam02355 471472003534 HMMPfam hit to PF02355, Protein export membrane protein, score 3.2e-97 471472003535 12 probable transmembrane helices predicted for CTL0708 by TMHMM2.0 at aa 9-31, 904-921, 923-945,955-977,998-1020, 1035-1057, 1085-1107, 1232-1251,1258-1280,1290-1309, 1340-1362 and 1367-1389 471472003536 PS00141 Eukaryotic and viral aspartyl proteases active site. 471472003537 HMMPfam hit to PF07549, SecD/SecF GG Motif, score 0.00038 471472003538 PS00037 Myb DNA-binding domain repeat signature 1. 471472003539 2 probable transmembrane helices predicted for CTL0709 by TMHMM2.0 at aa 43-65 and 69-88 471472003540 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 471472003541 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 471472003542 active site 471472003543 dimer interface [polypeptide binding]; other site 471472003544 HMMPfam hit to PF01255, Putative undecaprenyl diphosphate syntha, score 4.3e-95 471472003545 PS00962 Ribosomal protein S2 signature 1. 471472003546 PS01066 Undecaprenyl pyrophosphate synthetase family signature. 471472003547 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 471472003548 HMMPfam hit to PF01148, Cytidylyltransferase family,score 4.3e-81 471472003549 7 probable transmembrane helices predicted for CTL0711 by TMHMM2.0 at aa 28-50, 71-90, 100-117,124-146,161-183, 203-222 and 232-251 471472003550 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 471472003551 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 471472003552 CMP-binding site; other site 471472003553 The sites determining sugar specificity; other site 471472003554 PS00017 ATP/GTP-binding site motif A (P-loop). 471472003555 HMMPfam hit to PF02224, Cytidylate kinase, score 3.4e-86 471472003556 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471472003557 putative acyl-acceptor binding pocket; other site 471472003558 HMMPfam hit to PF01553, Acyltransferase, score 7.1e-26 471472003559 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 471472003560 arginine-tRNA ligase; Region: PLN02286 471472003561 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 471472003562 active site 471472003563 HIGH motif; other site 471472003564 KMSK motif region; other site 471472003565 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471472003566 tRNA binding surface [nucleotide binding]; other site 471472003567 anticodon binding site; other site 471472003568 HMMPfam hit to PF03485, Arginyl tRNA synthetase N terminal do, score 1.8e-20 471472003569 HMMPfam hit to PF00750, tRNA synthetases class I (R), score 9.5e-110 471472003570 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 471472003571 HMMPfam hit to PF05746, DALR anticodon binding domain, score 6.3e-37 471472003572 PS00527 Ribosomal protein S14 signature. 471472003573 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 471472003574 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 471472003575 hinge; other site 471472003576 active site 471472003577 HMMPfam hit to PF00275, EPSP synthase (3-phosphoshikimate 1-car, score 3.6e-118 471472003578 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 471472003579 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 471472003580 HMMPfam hit to PF07577, Domain of Unknown Function (DUF1547), score 2.3e-29 471472003581 HMMPfam hit to PF07577, Domain of Unknown Function (DUF1547), score 3.3e-29 471472003582 DNA-binding regulatory protein, YebC/PmpR family; Region: TIGR01033 471472003583 HMMPfam hit to PF01709, Domain of unknown function DUF28, score 2.7e-134 471472003584 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471472003585 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471472003586 Coenzyme A binding pocket [chemical binding]; other site 471472003587 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.5e-19 471472003588 peptide chain release factor 2; Validated; Region: prfB; PRK00578 471472003589 PCRF domain; Region: PCRF; pfam03462 471472003590 RF-1 domain; Region: RF-1; pfam00472 471472003591 HMMPfam hit to PF00472, Peptidyl-tRNA hydrolase domain, score 7e-75 471472003592 PS00745 Prokaryotic-type class I peptide chain release factors signature. 471472003593 HMMPfam hit to PF03462, PCRF domain, score 1.3e-52 471472003594 SWI complex, BAF60b domains; Region: SWIB; smart00151 471472003595 HMMPfam hit to PF02201, SWIB/MDM2 domain, score 1.5e-39 471472003596 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 471472003597 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 471472003598 putative active site [active] 471472003599 putative metal binding site [ion binding]; other site 471472003600 1 probable transmembrane helix predicted for CTL0721 by TMHMM2.0 at aa 2-24 471472003601 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 5.8e-23 471472003602 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 471472003603 substrate binding site; other site 471472003604 dimer interface; other site 471472003605 HMMPfam hit to PF01128, Uncharacterized protein family UPF0007, score 2.7e-25 471472003606 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 471472003607 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 471472003608 dimerization interface 3.5A [polypeptide binding]; other site 471472003609 active site 471472003610 HMMPfam hit to PF01416, tRNA pseudouridine synthase,score 3.1e-32 471472003611 HMMPfam hit to PF01416, tRNA pseudouridine synthase,score 3e-37 471472003612 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 471472003613 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 471472003614 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471472003615 active site 471472003616 motif I; other site 471472003617 motif II; other site 471472003618 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 4.8e-22 471472003619 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472003620 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 471472003621 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471472003622 putative active site [active] 471472003623 heme pocket [chemical binding]; other site 471472003624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471472003625 dimer interface [polypeptide binding]; other site 471472003626 phosphorylation site [posttranslational modification] 471472003627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471472003628 ATP binding site [chemical binding]; other site 471472003629 Mg2+ binding site [ion binding]; other site 471472003630 G-X-G motif; other site 471472003631 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 7.4e-20 471472003632 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 5.6e-22 471472003633 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471472003634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471472003635 active site 471472003636 phosphorylation site [posttranslational modification] 471472003637 intermolecular recognition site; other site 471472003638 dimerization interface [polypeptide binding]; other site 471472003639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471472003640 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471472003641 Walker A motif; other site 471472003642 ATP binding site [chemical binding]; other site 471472003643 Walker B motif; other site 471472003644 arginine finger; other site 471472003645 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.5e-35 471472003646 HMMPfam hit to PF00158, Sigma-54 interaction domain,score 7e-137 471472003647 PS00688 Sigma-54 interaction domain C-terminal part signature. 471472003648 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 471472003649 Recombination protein O N terminal; Region: RecO_N; pfam11967 471472003650 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 471472003651 Recombination protein O C terminal; Region: RecO_C; pfam02565 471472003652 HMMPfam hit to PF02565, Recombination protein O,score 1.4e-131 471472003653 1 probable transmembrane helix predicted for CTL0731 by TMHMM2.0 at aa 7-29 471472003654 Uncharacterized conserved protein [Function unknown]; Region: COG1723 471472003655 HMMPfam hit to PF02582, Uncharacterised ACR, YagE family COG1723, score 5.4e-136 471472003656 hypothetical protein; Provisional; Region: PRK14377 471472003657 HMMPfam hit to PF01809, Domain of unknown function DUF37, score 4e-40 471472003658 1 probable transmembrane helix predicted for CTL0735 by TMHMM2.0 at aa 24-43 471472003659 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 471472003660 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 471472003661 putative tRNA-binding site [nucleotide binding]; other site 471472003662 B3/4 domain; Region: B3_4; pfam03483 471472003663 tRNA synthetase B5 domain; Region: B5; pfam03484 471472003664 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 471472003665 dimer interface [polypeptide binding]; other site 471472003666 motif 1; other site 471472003667 motif 3; other site 471472003668 motif 2; other site 471472003669 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 471472003670 HMMPfam hit to PF01588, Putative tRNA binding domain, score 6.1e-36 471472003671 HMMPfam hit to PF03483, B3/4 domain, score 2.2e-77 471472003672 HMMPfam hit to PF03484, tRNA synthetase B5 domain,score 2.4e-24 471472003673 HMMPfam hit to PF03147, Ferredoxin-fold anticodon binding domain, score 1.5e-38 471472003674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 471472003675 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 471472003676 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 471472003677 DNA binding site [nucleotide binding] 471472003678 active site 471472003679 HMMPfam hit to PF01035, 6-O-methylguanine DNA methyltransferase, score 3.8e-05 471472003680 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 471472003681 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471472003682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471472003683 dimer interface [polypeptide binding]; other site 471472003684 conserved gate region; other site 471472003685 putative PBP binding loops; other site 471472003686 ABC-ATPase subunit interface; other site 471472003687 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.3e-31 471472003688 8 probable transmembrane helices predicted for CTL0739 by TMHMM2.0 at aa 20-42, 72-94, 101-123,378-400,412-434, 439-461, 490-512 and 546-568 471472003689 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471472003690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471472003691 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1e-27 471472003692 5 probable transmembrane helices predicted for CTL0740 by TMHMM2.0 at aa 239-261, 268-290, 330-347,392-414 and 434-453 471472003693 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 471472003694 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 471472003695 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 1.5e-21 471472003696 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 471472003697 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 471472003698 putative active site [active] 471472003699 putative metal binding site [ion binding]; other site 471472003700 HMMPfam hit to PF01522, Polysaccharide deacetylase,score 8.5e-05 471472003701 1 probable transmembrane helix predicted for CTL0743 by TMHMM2.0 at aa 12-34 471472003702 2 probable transmembrane helices predicted for CTL0744 by TMHMM2.0 at aa 40-62 and 82-104 471472003703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471472003704 binding surface 471472003705 TPR motif; other site 471472003706 2 probable transmembrane helices predicted for CTL0745 by TMHMM2.0 at aa 30-52 and 57-79 471472003707 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 471472003708 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 471472003709 C-terminal domain interface [polypeptide binding]; other site 471472003710 active site 471472003711 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 471472003712 active site 471472003713 N-terminal domain interface [polypeptide binding]; other site 471472003714 HMMPfam hit to PF00762, Ferrochelatase, score 8.3e-145 471472003715 PS00534 Ferrochelatase signature. 471472003716 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 471472003717 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471472003718 substrate binding pocket [chemical binding]; other site 471472003719 membrane-bound complex binding site; other site 471472003720 hinge residues; other site 471472003721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471472003722 S-adenosylmethionine binding site [chemical binding]; other site 471472003723 HMMPfam hit to PF03602, Conserved hypothetical protein, score 4.8e-86 471472003724 PS00092 N-6 Adenine-specific DNA methylases signature. 471472003725 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 471472003726 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 2.1e-16 471472003727 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 471472003728 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 471472003729 ligand binding site; other site 471472003730 oligomer interface; other site 471472003731 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 471472003732 N-terminal domain interface [polypeptide binding]; other site 471472003733 sulfate 1 binding site; other site 471472003734 HMMPfam hit to PF00483, Nucleotidyl transferase,score 1.6e-48 471472003735 PS00809 ADP-glucose pyrophosphorylase signature 2. 471472003736 transcription termination factor Rho; Region: rho; TIGR00767 471472003737 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 471472003738 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 471472003739 RNA binding site [nucleotide binding]; other site 471472003740 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 471472003741 multimer interface [polypeptide binding]; other site 471472003742 Walker A motif; other site 471472003743 ATP binding site [chemical binding]; other site 471472003744 Walker B motif; other site 471472003745 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleoti, score 4.3e-74 471472003746 PS00017 ATP/GTP-binding site motif A (P-loop). 471472003747 HMMPfam hit to PF07497, Rho termination factor,RNA-binding doma, score 4.3e-55 471472003748 HMMPfam hit to PF07498, Rho termination factor,N-terminal domai, score 1.6e-13 471472003749 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 471472003750 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 471472003751 CoA-binding site [chemical binding]; other site 471472003752 ATP-binding [chemical binding]; other site 471472003753 HMMPfam hit to PF01121, Dephospho-CoA kinase, score 1.3e-17 471472003754 PS00017 ATP/GTP-binding site motif A (P-loop). 471472003755 DNA polymerase I; Provisional; Region: PRK05755 471472003756 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 471472003757 active site 471472003758 metal binding site 1 [ion binding]; metal-binding site 471472003759 putative 5' ssDNA interaction site; other site 471472003760 metal binding site 3; metal-binding site 471472003761 metal binding site 2 [ion binding]; metal-binding site 471472003762 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 471472003763 putative DNA binding site [nucleotide binding]; other site 471472003764 putative metal binding site [ion binding]; other site 471472003765 3'-5' exonuclease; Region: 35EXOc; smart00474 471472003766 active site 471472003767 substrate binding site [chemical binding]; other site 471472003768 catalytic site [active] 471472003769 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 471472003770 active site 471472003771 DNA binding site [nucleotide binding] 471472003772 catalytic site [active] 471472003773 HMMPfam hit to PF00476, DNA polymerase family A,score 2.3e-128 471472003774 HMMPfam hit to PF01367, 5'-3' exonuclease,C-terminal SAM fold, score 1e-52 471472003775 HMMPfam hit to PF02739, 5'-3' exonuclease,N-terminal resolvase-, score 5.5e-86 471472003776 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 471472003777 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 471472003778 tandem repeat interface [polypeptide binding]; other site 471472003779 oligomer interface [polypeptide binding]; other site 471472003780 active site residues [active] 471472003781 HMMPfam hit to PF01343, Peptidase family S49, score 1.3e-31 471472003782 1 probable transmembrane helix predicted for CTL0755 by TMHMM2.0 at aa 12-34 471472003783 TLC ATP/ADP transporter; Region: TLC; pfam03219 471472003784 HMMPfam hit to PF03219, TLC ATP/ADP transporter,score 0 471472003785 12 probable transmembrane helices predicted for CTL0756 by TMHMM2.0 at aa 21-43, 58-80, 93-115,148-170,183-205, 220-242, 287-309, 329-351, 358-380,390-409,448-470 and 475-497 471472003786 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 471472003787 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 7.3e-27 471472003788 4 probable transmembrane helices predicted for CTL0757 by TMHMM2.0 at aa 13-35, 82-104, 116-135 and 139-156 471472003789 PS00379 CDP-alcohol phosphatidyltransferases signature. 471472003790 1 probable transmembrane helix predicted for CTL0758 by TMHMM2.0 at aa 4-21 471472003791 replicative DNA helicase; Provisional; Region: PRK06321 471472003792 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 471472003793 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 471472003794 Walker A motif; other site 471472003795 ATP binding site [chemical binding]; other site 471472003796 Walker B motif; other site 471472003797 DNA binding loops [nucleotide binding] 471472003798 HMMPfam hit to PF00772, DnaB-like helicase N terminal domain, score 7.9e-37 471472003799 HMMPfam hit to PF03796, DnaB-like helicase C terminal domain, score 8.9e-123 471472003800 PS00017 ATP/GTP-binding site motif A (P-loop). 471472003801 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 471472003802 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 471472003803 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 471472003804 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 471472003805 HMMPfam hit to PF01134, Glucose inhibited division protein A, score 1.8e-242 471472003806 PS00017 ATP/GTP-binding site motif A (P-loop). 471472003807 PS01280 Glucose inhibited division protein A family signature 1. 471472003808 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 471472003809 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase famil, score 9.3e-10 471472003810 Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; Region: NDK; smart00562 471472003811 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 471472003812 active site 471472003813 multimer interface [polypeptide binding]; other site 471472003814 HMMPfam hit to PF00334, Nucleoside diphosphate kinase, score 9.4e-73 471472003815 PS00469 Nucleoside diphosphate kinases active site. 471472003816 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 471472003817 RuvA N terminal domain; Region: RuvA_N; pfam01330 471472003818 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 471472003819 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 471472003820 HMMPfam hit to PF01330, RuvA N terminal domain,score 2.5e-25 471472003821 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 471472003822 active site 471472003823 putative DNA-binding cleft [nucleotide binding]; other site 471472003824 dimer interface [polypeptide binding]; other site 471472003825 HMMPfam hit to PF02075, Crossover junction endodeoxyribonuclease Ruv, score 5.4e-67 471472003826 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 471472003827 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 471472003828 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 471472003829 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 471472003830 HMMPfam hit to PF02800, Glyceraldehyde 3-phosphate dehydrogenase, C-, score 1.7e-106 471472003831 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 471472003832 HMMPfam hit to PF00044, Glyceraldehyde 3-phosphate dehydrogenase, NA, score 6.7e-88 471472003833 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 471472003834 HMMPfam hit to PF01196, Ribosomal protein L17,score 5.8e-78 471472003835 PS01167 Ribosomal protein L17 signature. 471472003836 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 471472003837 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 471472003838 alphaNTD - beta interaction site [polypeptide binding]; other site 471472003839 alphaNTD homodimer interface [polypeptide binding]; other site 471472003840 alphaNTD - beta' interaction site [polypeptide binding]; other site 471472003841 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 471472003842 HMMPfam hit to PF03118, Bacterial RNA polymerase,alpha chain C, score 1.7e-34 471472003843 HMMPfam hit to PF01193, RNA polymerase Rpb3/Rpb11 dimerisation, score 2.8e-19 471472003844 HMMPfam hit to PF01000, RNA polymerase Rpb3/RpoA insert domain, score 1.7e-16 471472003845 30S ribosomal protein S11; Validated; Region: PRK05309 471472003846 HMMPfam hit to PF00411, Ribosomal protein S11,score 5.3e-55 471472003847 PS00054 Ribosomal protein S11 signature. 471472003848 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 471472003849 HMMPfam hit to PF00416, Ribosomal protein S13/S18,score 2.1e-49 471472003850 PS00646 Ribosomal protein S13 signature. 471472003851 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 471472003852 SecY translocase; Region: SecY; pfam00344 471472003853 HMMPfam hit to PF00344, eubacterial secY protein,score 9.3e-212 471472003854 10 probable transmembrane helices predicted for CTL0772 by TMHMM2.0 at aa 17-39, 73-95, 120-142,157-179,192-214, 229-251, 285-307, 317-339, 384-406 and 410-429 471472003855 PS00756 Protein secY signature 2. 471472003856 PS00755 Protein secY signature 1. 471472003857 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 471472003858 HMMPfam hit to PF01305, Ribosomal protein L15 amino terminal re, score 1.1e-62 471472003859 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 471472003860 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 471472003861 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 471472003862 HMMPfam hit to PF03719, Ribosomal protein S5,C-terminal domai, score 5.5e-42 471472003863 HMMPfam hit to PF00333, Ribosomal protein S5,N-terminal domai, score 1.3e-37 471472003864 PS00585 Ribosomal protein S5 signature. 471472003865 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 471472003866 5S rRNA interface [nucleotide binding]; other site 471472003867 L27 interface [polypeptide binding]; other site 471472003868 23S rRNA interface [nucleotide binding]; other site 471472003869 L5 interface [polypeptide binding]; other site 471472003870 HMMPfam hit to PF00861, Ribosomal L18p/L5e family,score 8.9e-53 471472003871 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 471472003872 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471472003873 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471472003874 HMMPfam hit to PF00347, Ribosomal protein L6, score 3.5e-28 471472003875 PS00525 Ribosomal protein L6 signature 1. 471472003876 HMMPfam hit to PF00347, Ribosomal protein L6, score 6.6e-16 471472003877 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 471472003878 HMMPfam hit to PF00410, Ribosomal protein S8, score 4.1e-68 471472003879 PS00053 Ribosomal protein S8 signature. 471472003880 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 471472003881 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 471472003882 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 471472003883 HMMPfam hit to PF00673, ribosomal L5P family C-terminus, score 2.6e-27 471472003884 HMMPfam hit to PF00281, Ribosomal protein L5, score 3e-32 471472003885 PS00358 Ribosomal protein L5 signature. 471472003886 PS00041 Bacterial regulatory proteins, araC family signature. 471472003887 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 471472003888 RNA binding site [nucleotide binding]; other site 471472003889 HMMPfam hit to PF00467, KOW motif, score 2.2e-08 471472003890 PS01108 Ribosomal protein L24 signature. 471472003891 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 471472003892 HMMPfam hit to PF00238, Ribosomal protein L14p/L23e,score 6.5e-80 471472003893 PS00049 Ribosomal protein L14 signature. 471472003894 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 471472003895 HMMPfam hit to PF00366, Ribosomal protein S17,score 1e-37 471472003896 PS00056 Ribosomal protein S17 signature. 471472003897 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 471472003898 23S rRNA interface [nucleotide binding]; other site 471472003899 putative translocon interaction site; other site 471472003900 signal recognition particle (SRP54) interaction site; other site 471472003901 L23 interface [polypeptide binding]; other site 471472003902 trigger factor interaction site; other site 471472003903 HMMPfam hit to PF00831, Ribosomal L29 protein,score 3.4e-15 471472003904 PS00579 Ribosomal protein L29 signature. 471472003905 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 471472003906 23S rRNA interface [nucleotide binding]; other site 471472003907 5S rRNA interface [nucleotide binding]; other site 471472003908 putative antibiotic binding site [chemical binding]; other site 471472003909 L25 interface [polypeptide binding]; other site 471472003910 L27 interface [polypeptide binding]; other site 471472003911 HMMPfam hit to PF00252, Ribosomal protein L16,score 2.6e-82 471472003912 PS00701 Ribosomal protein L16 signature 2. 471472003913 PS00586 Ribosomal protein L16 signature 1. 471472003914 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 471472003915 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 471472003916 G-X-X-G motif; other site 471472003917 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 471472003918 HMMPfam hit to PF00189, Ribosomal protein S3,C-terminal domai, score 5.7e-49 471472003919 PS00548 Ribosomal protein S3 signature. 471472003920 HMMPfam hit to PF07650, KH domain, score 7.2e-24 471472003921 HMMPfam hit to PF00417, Ribosomal protein S3,N-terminal domai, score 2.7e-12 471472003922 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 471472003923 putative translocon binding site; other site 471472003924 protein-rRNA interface [nucleotide binding]; other site 471472003925 HMMPfam hit to PF00237, Ribosomal protein L22p/L17e,score 7.6e-26 471472003926 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 471472003927 HMMPfam hit to PF00203, Ribosomal protein S19,score 2.9e-45 471472003928 PS00323 Ribosomal protein S19 signature. 471472003929 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 471472003930 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 471472003931 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 471472003932 HMMPfam hit to PF03947, Ribosomal Proteins L2,C-terminal doma, score 1.3e-80 471472003933 PS00467 Ribosomal protein L2 signature. 471472003934 HMMPfam hit to PF00181, Ribosomal Proteins L2, RNA binding dom, score 1.6e-41 471472003935 Ribosomal protein L23 [Translation, ribosomal structure and biogenesis]; Region: RplW; COG0089 471472003936 HMMPfam hit to PF00276, Ribosomal protein L23,score 0.00011 471472003937 PS00215 Mitochondrial energy transfer proteins signature. 471472003938 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 471472003939 HMMPfam hit to PF00573, Ribosomal protein L4/L1 family, score 3.3e-88 471472003940 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 471472003941 HMMPfam hit to PF00297, Ribosomal protein L3, score 3.4e-55 471472003942 2 probable transmembrane helices predicted for CTL0791 by TMHMM2.0 at aa 136-158 and 272-294 471472003943 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 471472003944 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 471472003945 putative active site [active] 471472003946 substrate binding site [chemical binding]; other site 471472003947 putative cosubstrate binding site; other site 471472003948 catalytic site [active] 471472003949 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 471472003950 substrate binding site [chemical binding]; other site 471472003951 HMMPfam hit to PF02911, Formyl transferase,C-terminal domain, score 6.1e-46 471472003952 HMMPfam hit to PF00551, Formyl transferase, score 1.6e-31 471472003953 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 471472003954 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 471472003955 active site 471472003956 PS00101 Hexapeptide-repeat containing-transferases signature. 471472003957 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 37 471472003958 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 11 471472003959 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 7.9 471472003960 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.0041 471472003961 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 4.4 471472003962 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.77 471472003963 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 53 471472003964 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.12 471472003965 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 471472003966 HMMPfam hit to PF07977, FabA-like domain, score 6.5e-59 471472003967 1 probable transmembrane helix predicted for CTL0794 by TMHMM2.0 at aa 60-82 471472003968 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 471472003969 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 471472003970 HMMPfam hit to PF03331, UDP-3-O-acyl N-acetylglycosamine deacetylase, score 3.3e-178 471472003971 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 471472003972 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 471472003973 putative active site [active] 471472003974 catalytic triad [active] 471472003975 putative dimer interface [polypeptide binding]; other site 471472003976 7 probable transmembrane helices predicted for CTL0796 by TMHMM2.0 at aa 24-46, 55-74, 84-106,113-135,161-183, 190-207 and 509-531 471472003977 HMMPfam hit to PF00795, Carbon-nitrogen hydrolase,score 4e-48 471472003978 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 471472003979 HMMPfam hit to PF03061, Thioesterase superfamily,score 3.4e-14 471472003980 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 471472003981 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 471472003982 active site 471472003983 catalytic site [active] 471472003984 substrate binding site [chemical binding]; other site 471472003985 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 471472003986 HMMPfam hit to PF00929, Exonuclease, score 3.9e-54 471472003987 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 471472003988 HMMPfam hit to PF02367, Uncharacterised P-loop hydrolase UPF0079, score 1.6e-62 471472003989 PS00017 ATP/GTP-binding site motif A (P-loop). 471472003990 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 471472003991 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471472003992 catalytic residues [active] 471472003993 HMMPfam hit to PF00085, Thioredoxin, score 1.1e-38 471472003994 PS00194 Thioredoxin family active site. 471472003995 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 471472003996 HMMPfam hit to PF00588, SpoU rRNA Methylase family,score 8e-43 471472003997 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 471472003998 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 471472003999 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 471472004000 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 3.2e-34 471472004001 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 471472004002 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 471472004003 HMMPfam hit to PF01346, Domain amino terminal to FKBP-type peptidyl-, score 1e-05 471472004004 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 471472004005 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 471472004006 dimer interface [polypeptide binding]; other site 471472004007 anticodon binding site; other site 471472004008 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 471472004009 homodimer interface [polypeptide binding]; other site 471472004010 motif 1; other site 471472004011 active site 471472004012 motif 2; other site 471472004013 GAD domain; Region: GAD; pfam02938 471472004014 motif 3; other site 471472004015 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 2.1e-199 471472004016 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 471472004017 HMMPfam hit to PF02938, GAD domain, score 4.2e-43 471472004018 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 471472004019 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 2.1e-21 471472004020 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 471472004021 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 471472004022 dimer interface [polypeptide binding]; other site 471472004023 motif 1; other site 471472004024 active site 471472004025 motif 2; other site 471472004026 motif 3; other site 471472004027 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 471472004028 anticodon binding site; other site 471472004029 HMMPfam hit to PF03129, Anticodon binding domain,score 8e-08 471472004030 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 3e-47 471472004031 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 471472004032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471472004033 putative substrate translocation pore; other site 471472004034 10 probable transmembrane helices predicted for CTL0806 by TMHMM2.0 at aa 29-48, 68-90, 103-125,183-205,263-282, 302-321, 334-351, 361-383, 390-412 and 422-444 471472004035 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.2e-64 471472004036 PS00942 glpT family of transporters signature. 471472004037 PS00340 Growth factor and cytokines receptors family signature 2. 471472004038 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 471472004039 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 471472004040 active site 471472004041 PHP Thumb interface [polypeptide binding]; other site 471472004042 metal binding site [ion binding]; metal-binding site 471472004043 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 471472004044 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 471472004045 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 471472004046 generic binding surface I; other site 471472004047 generic binding surface II; other site 471472004048 HMMPfam hit to PF02811, PHP domain, score 1.4e-65 471472004049 HMMPfam hit to PF07733, Bacterial DNA polymerase III alpha sub, score 7.7e-271 471472004050 TPR repeat; Region: TPR_11; pfam13414 471472004051 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471472004052 binding surface 471472004053 TPR motif; other site 471472004054 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 471472004055 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 0.02 471472004056 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 0.3 471472004057 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 0.0021 471472004058 1 probable transmembrane helix predicted for CTL0810 by TMHMM2.0 at aa 5-27 471472004059 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472004060 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 471472004061 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 471472004062 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 471472004063 2 probable transmembrane helices predicted for CTL0813 by TMHMM2.0 at aa 5-24 and 397-419 471472004064 HMMPfam hit to PF00768, D-alanyl-D-alanine carboxypeptidase, score 9.6e-23 471472004065 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 471472004066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471472004067 S-adenosylmethionine binding site [chemical binding]; other site 471472004068 HMMPfam hit to PF01189, NOL1/NOP2/sun family, score 2.8e-09 471472004069 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 471472004070 HMMPfam hit to PF05525, Branched-chain amino acid transport p, score 5.6e-15 471472004071 10 probable transmembrane helices predicted for CTL0817 by TMHMM2.0 at aa 12-34, 44-66, 87-109,124-143,150-171, 202-221, 251-273, 302-324, 336-358 and 363-385 471472004072 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 471472004073 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471472004074 ATP binding site [chemical binding]; other site 471472004075 putative Mg++ binding site [ion binding]; other site 471472004076 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471472004077 ATP-binding site [chemical binding]; other site 471472004078 HMMPfam hit to PF04434, SWIM zinc finger, score 0.00011 471472004079 HMMPfam hit to PF00176, SNF2 family N-terminal domain, score 5.6e-57 471472004080 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 6.2e-18 471472004081 2 probable transmembrane helices predicted for CTL0819 by TMHMM2.0 at aa 99-121 and 136-153 471472004082 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 471472004083 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 471472004084 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471472004085 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 471472004086 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 471472004087 HMMPfam hit to PF03486, HI0933-like protein, score 0.00088 471472004088 HMMPfam hit to PF01134, Glucose inhibited division protein A, score 3.8e-18 471472004089 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidored, score 9.6e-77 471472004090 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 471472004091 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidored, score 2.3e-32 471472004092 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidored, score 1e-48 471472004093 lipoate synthase; Region: lipA; TIGR00510 471472004094 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471472004095 FeS/SAM binding site; other site 471472004096 HMMPfam hit to PF04055, Radical SAM superfamily,score 2.2e-17 471472004097 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 471472004098 HMMPfam hit to PF01514, Secretory protein of YscJ/FliF family, score 6.4e-32 471472004099 1 probable transmembrane helix predicted for CTL0822 by TMHMM2.0 at aa 236-258 471472004100 type III secretion system protein; Validated; Region: PRK06328 471472004101 Flagellar assembly protein FliH; Region: FliH; pfam02108 471472004102 type III secretion system protein; Reviewed; Region: PRK09617 471472004103 5 probable transmembrane helices predicted for CTL0825 by TMHMM2.0 at aa 7-29, 93-115, 135-157, 245-267 and 274-296 471472004104 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472004105 HMMPfam hit to PF00813, FliP family, score 1.9e-73 471472004106 PS01061 Flagella transport protein fliP family signature 2. 471472004107 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 471472004108 HMMPfam hit to PF01313, Bacterial export proteins,family, score 5.2e-27 471472004109 2 probable transmembrane helices predicted for CTL0826 by TMHMM2.0 at aa 20-42 and 62-84 471472004110 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 471472004111 HMMPfam hit to PF01311, Bacterial export proteins,family, score 1e-14 471472004112 6 probable transmembrane helices predicted for CTL0827 by TMHMM2.0 at aa 26-48, 52-74, 87-109,145-167,203-225 and 240-262 471472004113 2 probable transmembrane helices predicted for CTL0828 by TMHMM2.0 at aa 50-72 and 113-135 471472004114 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 471472004115 HMMPfam hit to PF07379, Protein of unknown function (DUF1494), score 4.2e-134 471472004116 1 probable transmembrane helix predicted for CTL0830 by TMHMM2.0 at aa 12-34 471472004117 1 probable transmembrane helix predicted for CTL0831 by TMHMM2.0 at aa 20-42 471472004118 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 471472004119 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 471472004120 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 471472004121 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 471472004122 3 probable transmembrane helices predicted for CTL0833 by TMHMM2.0 at aa 160-182, 207-229 and 364-386 471472004123 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 7.6e-18 471472004124 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 1.8e-21 471472004125 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 471472004126 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 471472004127 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 471472004128 Walker A motif; other site 471472004129 ATP binding site [chemical binding]; other site 471472004130 Walker B motif; other site 471472004131 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 4.9e-116 471472004132 PS00662 Bacterial type II secretion system protein E signature. 471472004133 PS00017 ATP/GTP-binding site motif A (P-loop). 471472004134 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 471472004135 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 471472004136 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 471472004137 HMMPfam hit to PF00263, Bacterial type II and III secretion system, score 6.6e-58 471472004138 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 2.2e-09 471472004139 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 4.8e-10 471472004140 1 probable transmembrane helix predicted for CTL0835 by TMHMM2.0 at aa 5-27 471472004141 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 471472004142 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 471472004143 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 471472004144 active site 471472004145 HMMPfam hit to PF00557, metallopeptidase family M24,score 4.6e-63 471472004146 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 471472004147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471472004148 ATP binding site [chemical binding]; other site 471472004149 Mg2+ binding site [ion binding]; other site 471472004150 G-X-G motif; other site 471472004151 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 471472004152 ATP binding site [chemical binding]; other site 471472004153 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 471472004154 HMMPfam hit to PF01119, DNA mismatch repair protein,C-termina, score 4.5e-47 471472004155 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and, score 9.9e-07 471472004156 PS00058 DNA mismatch repair proteins mutL / hexB / PMS1 signature. 471472004157 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 471472004158 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471472004159 binding surface 471472004160 TPR motif; other site 471472004161 HMMPfam hit to PF07720, Tetratricopeptide repeat,score 4.7e-08 471472004162 HMMPfam hit to PF07720, Tetratricopeptide repeat,score 2 471472004163 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 471472004164 1 probable transmembrane helix predicted for CTL0841 by TMHMM2.0 at aa 256-278 471472004165 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 471472004166 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 471472004167 EamA-like transporter family; Region: EamA; pfam00892 471472004168 EamA-like transporter family; Region: EamA; pfam00892 471472004169 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 5.8e-19 471472004170 10 probable transmembrane helices predicted for CTL0843 by TMHMM2.0 at aa 13-35, 50-72, 85-107,117-134,143-162, 172-194, 207-229, 239-261, 268-290 and 295-314 471472004171 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 9.3e-25 471472004172 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 471472004173 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cd01616 471472004174 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 471472004175 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 471472004176 active site 471472004177 dimer interface [polypeptide binding]; other site 471472004178 motif 1; other site 471472004179 motif 2; other site 471472004180 motif 3; other site 471472004181 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 471472004182 anticodon binding site; other site 471472004183 HMMPfam hit to PF02824, TGS domain, score 1.8e-15 471472004184 HMMPfam hit to PF07973, Threonyl and Alanyl tRNA synthetase se, score 2.3e-21 471472004185 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 3.2e-65 471472004186 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 471472004187 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 471472004188 HMMPfam hit to PF03129, Anticodon binding domain,score 9.3e-29 471472004189 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471472004190 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471472004191 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471472004192 P-loop; other site 471472004193 Magnesium ion binding site [ion binding]; other site 471472004194 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 5.7e-37 471472004195 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 471472004196 HMMPfam hit to PF03677, Uncharacterised protein family (UPF0137), score 1.2e-155 471472004197 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 471472004198 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 471472004199 active site 471472004200 HIGH motif; other site 471472004201 dimer interface [polypeptide binding]; other site 471472004202 KMSKS motif; other site 471472004203 HMMPfam hit to PF00579, tRNA synthetases class I (W and Y), score 2.1e-109 471472004204 excinuclease ABC subunit B; Provisional; Region: PRK05298 471472004205 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471472004206 ATP binding site [chemical binding]; other site 471472004207 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471472004208 nucleotide binding region [chemical binding]; other site 471472004209 ATP-binding site [chemical binding]; other site 471472004210 Ultra-violet resistance protein B; Region: UvrB; pfam12344 471472004211 UvrB/uvrC motif; Region: UVR; pfam02151 471472004212 HMMPfam hit to PF04851, Type III restriction enzyme,res subunit, score 9.1e-06 471472004213 PS00017 ATP/GTP-binding site motif A (P-loop). 471472004214 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 2e-19 471472004215 HMMPfam hit to PF02151, UvrB/uvrC motif, score 1.9e-06 471472004216 phosphopyruvate hydratase; Region: eno; TIGR01060 471472004217 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 471472004218 dimer interface [polypeptide binding]; other site 471472004219 metal binding site [ion binding]; metal-binding site 471472004220 substrate binding pocket [chemical binding]; other site 471472004221 HMMPfam hit to PF03952, Enolase, N-terminal domain,score 2e-56 471472004222 HMMPfam hit to PF00113, Enolase, C-terminal TIM barrel domain, score 8.2e-146 471472004223 PS00164 Enolase signature. 471472004224 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 471472004225 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471472004226 dimerization interface [polypeptide binding]; other site 471472004227 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 471472004228 2 probable transmembrane helices predicted for CTL0851 by TMHMM2.0 at aa 20-42 and 316-335 471472004229 HMMPfam hit to PF00672, HAMP domain, score 4.2e-09 471472004230 HMMPfam hit to PF07228, Stage II sporulation protein E (SpoIIE), score 9e-61 471472004231 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 471472004232 1 probable transmembrane helix predicted for CTL0852 by TMHMM2.0 at aa 9-31 471472004233 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 471472004234 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 471472004235 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 471472004236 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.0064 471472004237 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 471472004238 L-aspartate oxidase; Provisional; Region: PRK06175 471472004239 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 471472004240 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 471472004241 HMMPfam hit to PF02910, Fumarate reductase/succinate dehydroge, score 2.4e-47 471472004242 HMMPfam hit to PF00890, FAD binding domain, score 3.8e-85 471472004243 PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. 471472004244 this CDS carries multiple frameshfift mutations. The sequence has been checked and is believed to be correct.succinate dehydrogenase, membrane component (pseudogene) 471472004245 5 probable transmembrane helices predicted for CTL0856 by TMHMM2.0 at aa 19-41, 65-87, 115-137, 220-242 and 262-284 471472004246 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 471472004247 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 471472004248 active site 471472004249 HMMPfam hit to PF04909, Amidohydrolase, score 0.0016 471472004250 HMMPfam hit to PF01026, TatD related DNase, score 6.6e-106 471472004251 PS01091 Uncharacterized protein family UPF0006 signature 3. 471472004252 PS01090 Uncharacterized protein family UPF0006 signature 2. 471472004253 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 471472004254 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 471472004255 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 471472004256 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 471472004257 DsbD alpha interface [polypeptide binding]; other site 471472004258 catalytic residues [active] 471472004259 PS00194 Thioredoxin family active site. 471472004260 8 probable transmembrane helices predicted for CTL0859 by TMHMM2.0 at aa 287-309, 330-352,367-389,416-438, 453-472, 493-510, 514-536 and 549-571 471472004261 HMMPfam hit to PF02683, Cytochrome C biogenesis protein transmembran, score 5.2e-05 471472004262 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 471472004263 3 probable transmembrane helices predicted for CTL0860 by TMHMM2.0 at aa 22-39, 141-163 and 178-200 471472004264 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 2e-51 471472004265 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 471472004266 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 0.00021 471472004267 1 probable transmembrane helix predicted for CTL0861 by TMHMM2.0 at aa 15-37 471472004268 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 471472004269 1 probable transmembrane helix predicted for CTL0861A by TMHMM2.0 at aa 7-29 471472004270 translocation protein TolB; Provisional; Region: tolB; PRK01029 471472004271 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471472004272 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471472004273 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471472004274 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 471472004275 HMMPfam hit to PF04052, TolB amino-terminal domain,score 1.5e-54 471472004276 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 9.7e-05 471472004277 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 2.4e-08 471472004278 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 2.6e-05 471472004279 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 0.28 471472004280 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 471472004281 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 471472004282 ligand binding site [chemical binding]; other site 471472004283 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 471472004284 HMMPfam hit to PF00691, OmpA family, score 2.7e-26 471472004285 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 471472004286 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471472004287 HMMPfam hit to PF01476, LysM domain, score 6.1e-17 471472004288 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 471472004289 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 471472004290 dimer interface [polypeptide binding]; other site 471472004291 decamer (pentamer of dimers) interface [polypeptide binding]; other site 471472004292 catalytic triad [active] 471472004293 peroxidatic and resolving cysteines [active] 471472004294 HMMPfam hit to PF00578, AhpC/TSA family, score 2.3e-87 471472004295 HMMPfam hit to PF08534, Redoxin, score 3.5e-10 471472004296 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 471472004297 chaperonin GroEL; Reviewed; Region: groEL; PRK12851 471472004298 HMMPfam hit to PF00118, TCP-1/cpn60 chaperonin family, score 7.9e-131 471472004299 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 471472004300 HMMPfam hit to PF07075, Protein of unknown function (DUF1343), score 2.4e-231 471472004301 1 probable transmembrane helix predicted for CTL0868 by TMHMM2.0 at aa 7-26 471472004302 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 471472004303 active site 471472004304 dimerization interface [polypeptide binding]; other site 471472004305 HMMPfam hit to PF01725, Ham1 family, score 3.9e-43 471472004306 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 471472004307 ligand binding site [chemical binding]; other site 471472004308 active site 471472004309 UGI interface [polypeptide binding]; other site 471472004310 catalytic site [active] 471472004311 HMMPfam hit to PF03167, Uracil DNA glycosylase superfamily, score 8e-76 471472004312 PS00130 Uracil-DNA glycosylase signature. 471472004313 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 471472004314 Part of AAA domain; Region: AAA_19; pfam13245 471472004315 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 471472004316 HMMPfam hit to PF00580, UvrD/REP helicase, score 6.3e-222 471472004317 PS00017 ATP/GTP-binding site motif A (P-loop). 471472004318 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 471472004319 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 471472004320 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 471472004321 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 471472004322 HMMPfam hit to PF00309, Sigma-54 factor, Activator interacting do, score 1e-17 471472004323 HMMPfam hit to PF04963, Sigma-54 factor, core binding domain, score 4.9e-08 471472004324 HMMPfam hit to PF04552, Sigma-54, DNA binding domain, score 3.9e-77 471472004325 PS00718 Sigma-54 factors family signature 2. 471472004326 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 471472004327 HMMPfam hit to PF03070, TENA/THI-4/PQQC family,score 5.9e-76 471472004328 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 471472004329 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 471472004330 folate binding site [chemical binding]; other site 471472004331 NADP+ binding site [chemical binding]; other site 471472004332 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 471472004333 catalytic center binding site [active] 471472004334 ATP binding site [chemical binding]; other site 471472004335 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 471472004336 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 471472004337 substrate binding pocket [chemical binding]; other site 471472004338 dimer interface [polypeptide binding]; other site 471472004339 inhibitor binding site; inhibition site 471472004340 PS00017 ATP/GTP-binding site motif A (P-loop). 471472004341 PS00794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. 471472004342 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 471472004343 homooctamer interface [polypeptide binding]; other site 471472004344 active site 471472004345 HMMPfam hit to PF02152, Dihydroneopterin aldolase,score 4e-47 471472004346 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 471472004347 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 471472004348 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 471472004349 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471472004350 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471472004351 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471472004352 DNA binding residues [nucleotide binding] 471472004353 HMMPfam hit to PF04545, Sigma-70, region, score 1.1e-23 471472004354 PS00716 Sigma-70 factors family signature 2. 471472004355 HMMPfam hit to PF04539, Sigma-70 region, score 4.2e-36 471472004356 HMMPfam hit to PF04542, Sigma-70 region, score 2.4e-28 471472004357 PS00715 Sigma-70 factors family signature 1. 471472004358 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature. 471472004359 HMMPfam hit to PF00140, Sigma-70 factor,region,score 2.2e-18 471472004360 HMMPfam hit to PF03979, Sigma-70 factor,region,score 3.8e-24 471472004361 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 471472004362 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 471472004363 HMMPfam hit to PF06785, Uncharacterised protein family (UPF0242), score 0 471472004364 2 probable transmembrane helices predicted for CTL0880 by TMHMM2.0 at aa 34-56 and 61-83 471472004365 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 471472004366 HMMPfam hit to PF01649, Ribosomal protein S20,score 1.3e-15 471472004367 2 probable transmembrane helices predicted for CTL0882 by TMHMM2.0 at aa 213-235 and 240-262 471472004368 Effector from type III secretion system; Region: Effector_1; pfam04518 471472004369 HMMPfam hit to PF04518, Protein of unknown function,DUF582, score 1.5e-179 471472004370 Effector from type III secretion system; Region: Effector_1; pfam04518 471472004371 HMMPfam hit to PF04518, Protein of unknown function,DUF582, score 1.2e-207 471472004372 Effector from type III secretion system; Region: Effector_1; pfam04518 471472004373 HMMPfam hit to PF04518, Protein of unknown function,DUF582, score 5e-209 471472004374 PS00962 Ribosomal protein S2 signature 1. 471472004375 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl19914 471472004376 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 471472004377 MviN-like protein; Region: MVIN; pfam03023 471472004378 13 probable transmembrane helices predicted for CTL0888 by TMHMM2.0 at aa 20-42, 86-108, 118-140,147-166,176-198, 221-243, 258-280, 300-322, 342-364,371-393,398-420, 441-463 and 478-500 471472004379 HMMPfam hit to PF03023, MviN-like protein, score 1.3e-187 471472004380 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 471472004381 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 471472004382 AP (apurinic/apyrimidinic) site pocket; other site 471472004383 DNA interaction; other site 471472004384 Metal-binding active site; metal-binding site 471472004385 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 8.2e-51 471472004386 PS00730 AP endonucleases family 2 signature 2. 471472004387 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 471472004388 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 471472004389 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471472004390 RNA binding surface [nucleotide binding]; other site 471472004391 HMMPfam hit to PF01479, S4 domain, score 2.2e-20 471472004392 HMMPfam hit to PF00163, Ribosomal protein S4/S9 N-terminal domai, score 1.2e-16 471472004393 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 471472004394 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 471472004395 active site residue [active] 471472004396 HMMPfam hit to PF00581, Rhodanese-like domain,score 1.6e-11 471472004397 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 471472004398 substrate binding pocket [chemical binding]; other site 471472004399 aspartate-rich region 2; other site 471472004400 substrate-Mg2+ binding site; other site 471472004401 HMMPfam hit to PF00348, Polyprenyl synthetase,score 3.2e-29 471472004402 PS00444 Polyprenyl synthetases signature 2. 471472004403 PS00723 Polyprenyl synthetases signature 1. 471472004404 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 471472004405 putative trimer interface [polypeptide binding]; other site 471472004406 putative CoA binding site [chemical binding]; other site 471472004407 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1.2 471472004408 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 58 471472004409 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 4.2 471472004410 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 3 471472004411 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471472004412 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 471472004413 DNA binding site [nucleotide binding] 471472004414 HMMPfam hit to PF00486, Transcriptional regulatory protein, C ter, score 2.6e-20 471472004415 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 471472004416 Thymidylate synthase complementing protein; Region: Thy1; cl03630