-- dump date 20140619_032001 -- class Genbank::misc_feature -- table misc_feature_note -- id note 759364000001 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 759364000002 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 759364000003 active site 759364000004 Int/Topo IB signature motif; other site 759364000005 catalytic residues [active] 759364000006 DNA binding site [nucleotide binding] 759364000007 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 759364000008 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 759364000009 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 759364000010 P-loop; other site 759364000011 Magnesium ion binding site [ion binding]; other site 759364000012 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 759364000013 Magnesium ion binding site [ion binding]; other site 759364000014 Chlamydia virulence protein PGP3-D; Region: Chlam_vir; pfam05475 759364000015 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 759364000016 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 759364000017 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 759364000018 Walker A motif; other site 759364000019 ATP binding site [chemical binding]; other site 759364000020 Walker B motif; other site 759364000021 DNA binding loops [nucleotide binding] 759364000022 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 759364000023 active site 759364000024 catalytic residues [active] 759364000025 DNA binding site [nucleotide binding] 759364000026 Int/Topo IB signature motif; other site 759364000027 Uncharacterized conserved protein [Function unknown]; Region: COG2155 759364000028 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 759364000029 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 759364000030 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 759364000031 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064 759364000032 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 759364000033 GatB domain; Region: GatB_Yqey; pfam02637 759364000034 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 759364000035 ribonuclease HIII; Region: rnhC; TIGR00716 759364000036 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 759364000037 RNA/DNA hybrid binding site [nucleotide binding]; other site 759364000038 active site 759364000039 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 759364000040 Helix-turn-helix domain; Region: HTH_25; pfam13413 759364000041 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK05906 759364000042 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 759364000043 putative acyl-acceptor binding pocket; other site 759364000044 Uncharacterized conserved protein [Function unknown]; Region: COG1624 759364000045 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 759364000046 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 759364000047 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 759364000048 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 759364000049 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 759364000050 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 759364000051 putative active site [active] 759364000052 PhoH-like protein; Region: PhoH; pfam02562 759364000053 Bacterial SH3 domain homologues; Region: SH3b; smart00287 759364000054 Bacterial SH3 domain homologues; Region: SH3b; smart00287 759364000055 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 759364000056 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 759364000057 HIGH motif; other site 759364000058 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 759364000059 active site 759364000060 KMSKS motif; other site 759364000061 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 759364000062 tRNA binding surface [nucleotide binding]; other site 759364000063 anticodon binding site; other site 759364000064 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 759364000065 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 759364000066 Catalytic site [active] 759364000067 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 759364000068 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 759364000069 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 759364000070 peptide chain release factor 1; Validated; Region: prfA; PRK00591 759364000071 PCRF domain; Region: PCRF; pfam03462 759364000072 RF-1 domain; Region: RF-1; pfam00472 759364000073 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 759364000074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759364000075 S-adenosylmethionine binding site [chemical binding]; other site 759364000076 signal recognition particle protein; Provisional; Region: PRK10867 759364000077 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 759364000078 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 759364000079 P loop; other site 759364000080 GTP binding site [chemical binding]; other site 759364000081 Signal peptide binding domain; Region: SRP_SPB; pfam02978 759364000082 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14522 759364000083 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Reviewed; Region: trmD; PRK01037 759364000084 tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmD; COG0336 759364000085 ribosomal protein L19, bacterial type; Region: rplS_bact; TIGR01024 759364000086 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 759364000087 RNA/DNA hybrid binding site [nucleotide binding]; other site 759364000088 active site 759364000089 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 759364000090 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 759364000091 catalytic site [active] 759364000092 G-X2-G-X-G-K; other site 759364000093 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 759364000094 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 759364000095 active site 759364000096 HIGH motif; other site 759364000097 KMSKS motif; other site 759364000098 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 759364000099 tRNA binding surface [nucleotide binding]; other site 759364000100 anticodon binding site; other site 759364000101 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 759364000102 AAA domain; Region: AAA_30; pfam13604 759364000103 Family description; Region: UvrD_C_2; pfam13538 759364000104 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 759364000105 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 759364000106 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 759364000107 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 759364000108 trimer interface [polypeptide binding]; other site 759364000109 active site 759364000110 Holliday junction resolvasome, helicase subunit [DNA replication, recombination, and repair]; Region: RuvB; COG2255 759364000111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759364000112 Walker A motif; other site 759364000113 ATP binding site [chemical binding]; other site 759364000114 Walker B motif; other site 759364000115 arginine finger; other site 759364000116 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 759364000117 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 759364000118 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 759364000119 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 759364000120 active site 759364000121 catalytic site [active] 759364000122 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 759364000123 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 759364000124 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 759364000125 dimer interface [polypeptide binding]; other site 759364000126 ssDNA binding site [nucleotide binding]; other site 759364000127 tetramer (dimer of dimers) interface [polypeptide binding]; other site 759364000128 multifunctional aminopeptidase A; Provisional; Region: PRK00913 759364000129 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 759364000130 interface (dimer of trimers) [polypeptide binding]; other site 759364000131 Substrate-binding/catalytic site; other site 759364000132 Zn-binding sites [ion binding]; other site 759364000133 hypothetical protein; Provisional; Region: PRK05907 759364000134 Predicted methyltransferases [General function prediction only]; Region: COG0313 759364000135 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 759364000136 putative SAM binding site [chemical binding]; other site 759364000137 homodimer interface [polypeptide binding]; other site 759364000138 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cl00322 759364000139 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 759364000140 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759364000141 FeS/SAM binding site; other site 759364000142 HemN C-terminal domain; Region: HemN_C; pfam06969 759364000143 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567 759364000144 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 759364000145 TPP-binding site [chemical binding]; other site 759364000146 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 759364000147 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 759364000148 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 759364000149 E3 interaction surface; other site 759364000150 lipoyl attachment site [posttranslational modification]; other site 759364000151 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 759364000152 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 759364000153 uncharacterized protein, YfiH family; Region: TIGR00726 759364000154 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 759364000155 1-hydroxy-2-methyl-2-(e)-butenyl 4-diphosphate synthase [Lipid metabolism]; Region: gcpE; COG0821 759364000156 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 759364000157 ADP-ribose binding site [chemical binding]; other site 759364000158 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 759364000159 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 759364000160 catalytic loop [active] 759364000161 iron binding site [ion binding]; other site 759364000162 type III secretion system protein; Validated; Region: PRK05910 759364000163 FHIPEP family; Region: FHIPEP; pfam00771 759364000164 RNA polymerase sigma factor sigma-28; Reviewed; Region: PRK05911 759364000165 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 759364000166 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 759364000167 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 759364000168 DNA binding residues [nucleotide binding] 759364000169 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 759364000170 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 759364000171 active site 759364000172 HIGH motif; other site 759364000173 dimer interface [polypeptide binding]; other site 759364000174 KMSKS motif; other site 759364000175 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 759364000176 RNA binding surface [nucleotide binding]; other site 759364000177 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 759364000178 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 759364000179 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 759364000180 GTP-binding protein LepA; Provisional; Region: PRK05433 759364000181 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 759364000182 G1 box; other site 759364000183 putative GEF interaction site [polypeptide binding]; other site 759364000184 GTP/Mg2+ binding site [chemical binding]; other site 759364000185 Switch I region; other site 759364000186 G2 box; other site 759364000187 G3 box; other site 759364000188 Switch II region; other site 759364000189 G4 box; other site 759364000190 G5 box; other site 759364000191 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 759364000192 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 759364000193 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 759364000194 ADP/ATP carrier protein family; Region: AAA; TIGR00769 759364000195 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 759364000196 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 759364000197 intersubunit interface [polypeptide binding]; other site 759364000198 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 759364000199 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 759364000200 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 759364000201 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 759364000202 ABC-ATPase subunit interface; other site 759364000203 dimer interface [polypeptide binding]; other site 759364000204 putative PBP binding regions; other site 759364000205 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 759364000206 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 759364000207 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 759364000208 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 759364000209 ABC-ATPase subunit interface; other site 759364000210 dimer interface [polypeptide binding]; other site 759364000211 putative PBP binding regions; other site 759364000212 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 759364000213 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 759364000214 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 759364000215 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 759364000216 RIP metalloprotease RseP; Region: TIGR00054 759364000217 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 759364000218 active site 759364000219 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 759364000220 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 759364000221 putative substrate binding region [chemical binding]; other site 759364000222 recF protein; Region: recf; TIGR00611 759364000223 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759364000224 Walker A/P-loop; other site 759364000225 ATP binding site [chemical binding]; other site 759364000226 Q-loop/lid; other site 759364000227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759364000228 ABC transporter signature motif; other site 759364000229 Walker B; other site 759364000230 DNA polymerase III subunit beta; Validated; Region: PRK05643 759364000231 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 759364000232 putative DNA binding surface [nucleotide binding]; other site 759364000233 dimer interface [polypeptide binding]; other site 759364000234 beta-clamp/clamp loader binding surface; other site 759364000235 beta-clamp/translesion DNA polymerase binding surface; other site 759364000236 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 759364000237 SmpB-tmRNA interface; other site 759364000238 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 759364000239 ApbE family; Region: ApbE; pfam02424 759364000240 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14181 759364000241 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 759364000242 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 759364000243 homodimer interface [polypeptide binding]; other site 759364000244 NADP binding site [chemical binding]; other site 759364000245 substrate binding site [chemical binding]; other site 759364000246 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 759364000247 PLD-like domain; Region: PLDc_2; pfam13091 759364000248 putative active site [active] 759364000249 catalytic site [active] 759364000250 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 759364000251 PLD-like domain; Region: PLDc_2; pfam13091 759364000252 putative active site [active] 759364000253 catalytic site [active] 759364000254 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 759364000255 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 759364000256 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 759364000257 4-alpha-glucanotransferase; Region: Glyco_hydro_77; pfam02446 759364000258 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 759364000259 HrpJ-like domain; Region: HrpJ; cl15454 759364000260 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 759364000261 FHIPEP family; Region: FHIPEP; pfam00771 759364000262 type III secretion system protein; Validated; Region: PRK06298 759364000263 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 759364000264 GTP-binding protein YchF; Reviewed; Region: PRK09601 759364000265 YchF GTPase; Region: YchF; cd01900 759364000266 G1 box; other site 759364000267 GTP/Mg2+ binding site [chemical binding]; other site 759364000268 Switch I region; other site 759364000269 G2 box; other site 759364000270 Switch II region; other site 759364000271 G3 box; other site 759364000272 G4 box; other site 759364000273 G5 box; other site 759364000274 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 759364000275 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 759364000276 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 759364000277 active site 759364000278 Riboflavin kinase; Region: Flavokinase; smart00904 759364000279 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00989 759364000280 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 759364000281 RNA binding site [nucleotide binding]; other site 759364000282 active site 759364000283 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 759364000284 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 759364000285 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 759364000286 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 759364000287 G1 box; other site 759364000288 putative GEF interaction site [polypeptide binding]; other site 759364000289 GTP/Mg2+ binding site [chemical binding]; other site 759364000290 Switch I region; other site 759364000291 G2 box; other site 759364000292 G3 box; other site 759364000293 Switch II region; other site 759364000294 G4 box; other site 759364000295 G5 box; other site 759364000296 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 759364000297 Translation-initiation factor 2; Region: IF-2; pfam11987 759364000298 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 759364000299 transcription termination factor NusA; Region: NusA; TIGR01953 759364000300 NusA N-terminal domain; Region: NusA_N; pfam08529 759364000301 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 759364000302 RNA binding site [nucleotide binding]; other site 759364000303 homodimer interface [polypeptide binding]; other site 759364000304 NusA-like KH domain; Region: KH_5; pfam13184 759364000305 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 759364000306 G-X-X-G motif; other site 759364000307 ribosomal protein S1; Region: rpsA; TIGR00717 759364000308 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 759364000309 RNA binding site [nucleotide binding]; other site 759364000310 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 759364000311 RNA binding site [nucleotide binding]; other site 759364000312 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 759364000313 RNA binding site [nucleotide binding]; other site 759364000314 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 759364000315 RNA binding site [nucleotide binding]; other site 759364000316 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 759364000317 RNA binding site [nucleotide binding]; other site 759364000318 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 759364000319 RNA binding site [nucleotide binding]; other site 759364000320 domain interface; other site 759364000321 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 759364000322 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 759364000323 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 759364000324 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 759364000325 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 759364000326 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 759364000327 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 759364000328 active site 759364000329 motif I; other site 759364000330 motif II; other site 759364000331 enoyl-[acyl-carrier-protein] reductase; Region: PLN02730 759364000332 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 759364000333 NAD binding site [chemical binding]; other site 759364000334 homotetramer interface [polypeptide binding]; other site 759364000335 homodimer interface [polypeptide binding]; other site 759364000336 substrate binding site [chemical binding]; other site 759364000337 active site 759364000338 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 759364000339 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 759364000340 RNA binding surface [nucleotide binding]; other site 759364000341 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 759364000342 active site 759364000343 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 759364000344 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 759364000345 minor groove reading motif; other site 759364000346 helix-hairpin-helix signature motif; other site 759364000347 substrate binding pocket [chemical binding]; other site 759364000348 active site 759364000349 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 759364000350 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 759364000351 DNA binding and oxoG recognition site [nucleotide binding] 759364000352 Uncharacterized conserved protein [Function unknown]; Region: COG0327 759364000353 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 759364000354 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 759364000355 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 759364000356 ring oligomerisation interface [polypeptide binding]; other site 759364000357 ATP/Mg binding site [chemical binding]; other site 759364000358 stacking interactions; other site 759364000359 hinge regions; other site 759364000360 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 759364000361 oligomerisation interface [polypeptide binding]; other site 759364000362 mobile loop; other site 759364000363 roof hairpin; other site 759364000364 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 759364000365 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 759364000366 active site 759364000367 Zn binding site [ion binding]; other site 759364000368 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 759364000369 Clp amino terminal domain; Region: Clp_N; pfam02861 759364000370 Clp amino terminal domain; Region: Clp_N; pfam02861 759364000371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759364000372 Walker A motif; other site 759364000373 ATP binding site [chemical binding]; other site 759364000374 Walker B motif; other site 759364000375 arginine finger; other site 759364000376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759364000377 Walker A motif; other site 759364000378 ATP binding site [chemical binding]; other site 759364000379 Walker B motif; other site 759364000380 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 759364000381 Uncharacterized conserved protein [Function unknown]; Region: COG2912 759364000382 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 759364000383 IncA protein; Region: IncA; pfam04156 759364000384 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 759364000385 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 759364000386 substrate binding site [chemical binding]; other site 759364000387 hexamer interface [polypeptide binding]; other site 759364000388 metal binding site [ion binding]; metal-binding site 759364000389 elongation factor P; Provisional; Region: PRK12426 759364000390 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 759364000391 RNA binding site [nucleotide binding]; other site 759364000392 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 759364000393 RNA binding site [nucleotide binding]; other site 759364000394 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 759364000395 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 759364000396 carboxyltransferase (CT) interaction site; other site 759364000397 biotinylation site [posttranslational modification]; other site 759364000398 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 759364000399 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 759364000400 ATP-grasp domain; Region: ATP-grasp_4; cl17255 759364000401 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 759364000402 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 759364000403 23S rRNA interface [nucleotide binding]; other site 759364000404 L3 interface [polypeptide binding]; other site 759364000405 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 759364000406 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 759364000407 NlpC/P60 family; Region: NLPC_P60; cl17555 759364000408 adenylate kinase; Reviewed; Region: adk; PRK00279 759364000409 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 759364000410 AMP-binding site [chemical binding]; other site 759364000411 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 759364000412 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 759364000413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759364000414 dimer interface [polypeptide binding]; other site 759364000415 conserved gate region; other site 759364000416 putative PBP binding loops; other site 759364000417 ABC-ATPase subunit interface; other site 759364000418 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 759364000419 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759364000420 Walker A/P-loop; other site 759364000421 ATP binding site [chemical binding]; other site 759364000422 Q-loop/lid; other site 759364000423 ABC transporter signature motif; other site 759364000424 Walker B; other site 759364000425 D-loop; other site 759364000426 H-loop/switch region; other site 759364000427 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 759364000428 Methyltransferase domain; Region: Methyltransf_23; pfam13489 759364000429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759364000430 S-adenosylmethionine binding site [chemical binding]; other site 759364000431 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 759364000432 Serine hydrolase (FSH1); Region: FSH1; pfam03959 759364000433 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 759364000434 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 759364000435 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 759364000436 active site 759364000437 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 759364000438 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 759364000439 conserved hypothetical integral membrane protein; Region: TIGR00697 759364000440 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 759364000441 SEC-C motif; Region: SEC-C; pfam02810 759364000442 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 759364000443 Catalytic domain of Protein Kinases; Region: PKc; cd00180 759364000444 active site 759364000445 ATP binding site [chemical binding]; other site 759364000446 substrate binding site [chemical binding]; other site 759364000447 activation loop (A-loop); other site 759364000448 Uncharacterized conserved protein [Function unknown]; Region: COG1262 759364000449 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 759364000450 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 759364000451 DNA ligase, NAD-dependent; Region: dnlj; TIGR00575 759364000452 nucleotide binding pocket [chemical binding]; other site 759364000453 K-X-D-G motif; other site 759364000454 catalytic site [active] 759364000455 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 759364000456 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 759364000457 Helix-hairpin-helix motif; Region: HHH; pfam00633 759364000458 helix-hairpin-helix signature motif; other site 759364000459 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 759364000460 Dimer interface [polypeptide binding]; other site 759364000461 BRCT sequence motif; other site 759364000462 hypothetical protein; Provisional; Region: PRK06184 759364000463 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 759364000464 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 759364000465 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 759364000466 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 759364000467 FtsX-like permease family; Region: FtsX; pfam02687 759364000468 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 759364000469 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 759364000470 Walker A/P-loop; other site 759364000471 ATP binding site [chemical binding]; other site 759364000472 Q-loop/lid; other site 759364000473 ABC transporter signature motif; other site 759364000474 Walker B; other site 759364000475 D-loop; other site 759364000476 H-loop/switch region; other site 759364000477 membrane-attack complex / perforin; Region: MACPF; smart00457 759364000478 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; Region: MIR; smart00472 759364000479 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 759364000480 PLD-like domain; Region: PLDc_2; pfam13091 759364000481 putative active site [active] 759364000482 catalytic site [active] 759364000483 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 759364000484 PLD-like domain; Region: PLDc_2; pfam13091 759364000485 putative active site [active] 759364000486 catalytic site [active] 759364000487 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 759364000488 PLD-like domain; Region: PLDc_2; pfam13091 759364000489 putative active site [active] 759364000490 catalytic site [active] 759364000491 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 759364000492 PLD-like domain; Region: PLDc_2; pfam13091 759364000493 putative active site [active] 759364000494 catalytic site [active] 759364000495 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 759364000496 PLD-like domain; Region: PLDc_2; pfam13091 759364000497 putative active site [active] 759364000498 catalytic site [active] 759364000499 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 759364000500 PLD-like domain; Region: PLDc_2; pfam13091 759364000501 putative active site [active] 759364000502 catalytic site [active] 759364000503 PLD-like domain; Region: PLDc_2; pfam13091 759364000504 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 759364000505 putative active site [active] 759364000506 catalytic site [active] 759364000507 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 759364000508 PLD-like domain; Region: PLDc_2; pfam13091 759364000509 putative active site [active] 759364000510 catalytic site [active] 759364000511 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 759364000512 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 759364000513 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 759364000514 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 759364000515 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 759364000516 trp operon repressor, proteobacterial; Region: TrpR; TIGR01321 759364000517 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 759364000518 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 759364000519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759364000520 catalytic residue [active] 759364000521 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 759364000522 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 759364000523 substrate binding site [chemical binding]; other site 759364000524 active site 759364000525 catalytic residues [active] 759364000526 heterodimer interface [polypeptide binding]; other site 759364000527 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 759364000528 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 759364000529 peptide binding site [polypeptide binding]; other site 759364000530 putative disulfide oxidoreductase; Provisional; Region: PRK00611 759364000531 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 759364000532 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 759364000533 Thioredoxin; Region: Thioredoxin_4; cl17273 759364000534 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 759364000535 putative active site [active] 759364000536 redox center [active] 759364000537 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 759364000538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759364000539 Walker A/P-loop; other site 759364000540 ATP binding site [chemical binding]; other site 759364000541 Q-loop/lid; other site 759364000542 ABC transporter signature motif; other site 759364000543 Walker B; other site 759364000544 D-loop; other site 759364000545 H-loop/switch region; other site 759364000546 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 759364000547 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 759364000548 Ligand binding site; other site 759364000549 oligomer interface; other site 759364000550 CTP synthetase; Validated; Region: pyrG; PRK05380 759364000551 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 759364000552 Catalytic site [active] 759364000553 active site 759364000554 UTP binding site [chemical binding]; other site 759364000555 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 759364000556 active site 759364000557 putative oxyanion hole; other site 759364000558 catalytic triad [active] 759364000559 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 759364000560 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 759364000561 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 759364000562 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 759364000563 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 759364000564 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 759364000565 putative active site [active] 759364000566 DNA polymerase III subunit delta'; Validated; Region: PRK05917 759364000567 DNA polymerase III subunit delta'; Validated; Region: PRK08485 759364000568 thymidylate kinase; Validated; Region: tmk; PRK00698 759364000569 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 759364000570 TMP-binding site; other site 759364000571 ATP-binding site [chemical binding]; other site 759364000572 DNA gyrase, A subunit; Region: gyrA; TIGR01063 759364000573 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 759364000574 CAP-like domain; other site 759364000575 active site 759364000576 primary dimer interface [polypeptide binding]; other site 759364000577 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759364000578 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759364000579 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759364000580 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759364000581 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759364000582 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759364000583 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 759364000584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759364000585 ATP binding site [chemical binding]; other site 759364000586 Mg2+ binding site [ion binding]; other site 759364000587 G-X-G motif; other site 759364000588 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 759364000589 anchoring element; other site 759364000590 dimer interface [polypeptide binding]; other site 759364000591 ATP binding site [chemical binding]; other site 759364000592 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 759364000593 active site 759364000594 putative metal-binding site [ion binding]; other site 759364000595 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 759364000596 Protein of unknown function (DUF721); Region: DUF721; pfam05258 759364000597 queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008 759364000598 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 759364000599 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 759364000600 MgtE intracellular N domain; Region: MgtE_N; pfam03448 759364000601 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 759364000602 Divalent cation transporter; Region: MgtE; pfam01769 759364000603 Metal-dependent proteases with possible chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: QRI7; COG0533 759364000604 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 759364000605 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 759364000606 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 759364000607 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 759364000608 peptide binding site [polypeptide binding]; other site 759364000609 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759364000610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759364000611 dimer interface [polypeptide binding]; other site 759364000612 conserved gate region; other site 759364000613 putative PBP binding loops; other site 759364000614 ABC-ATPase subunit interface; other site 759364000615 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759364000616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759364000617 dimer interface [polypeptide binding]; other site 759364000618 conserved gate region; other site 759364000619 putative PBP binding loops; other site 759364000620 ABC-ATPase subunit interface; other site 759364000621 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759364000622 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 759364000623 Walker A/P-loop; other site 759364000624 ATP binding site [chemical binding]; other site 759364000625 Q-loop/lid; other site 759364000626 ABC transporter signature motif; other site 759364000627 Walker B; other site 759364000628 D-loop; other site 759364000629 H-loop/switch region; other site 759364000630 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 759364000631 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 759364000632 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759364000633 Walker A/P-loop; other site 759364000634 ATP binding site [chemical binding]; other site 759364000635 Q-loop/lid; other site 759364000636 ABC transporter signature motif; other site 759364000637 Walker B; other site 759364000638 D-loop; other site 759364000639 H-loop/switch region; other site 759364000640 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759364000641 Protein of unknown function (DUF1186); Region: DUF1186; pfam06685 759364000642 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 759364000643 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 759364000644 transmembrane helices; other site 759364000645 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 759364000646 active site 759364000647 ADP/pyrophosphate binding site [chemical binding]; other site 759364000648 dimerization interface [polypeptide binding]; other site 759364000649 allosteric effector site; other site 759364000650 fructose-1,6-bisphosphate binding site; other site 759364000651 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 759364000652 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 759364000653 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 759364000654 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 759364000655 active site 759364000656 ADP/pyrophosphate binding site [chemical binding]; other site 759364000657 dimerization interface [polypeptide binding]; other site 759364000658 allosteric effector site; other site 759364000659 fructose-1,6-bisphosphate binding site; other site 759364000660 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 759364000661 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 759364000662 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 759364000663 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 759364000664 HIGH motif; other site 759364000665 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 759364000666 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 759364000667 active site 759364000668 KMSKS motif; other site 759364000669 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 759364000670 tRNA binding surface [nucleotide binding]; other site 759364000671 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00615 759364000672 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 759364000673 inhibitor-cofactor binding pocket; inhibition site 759364000674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759364000675 catalytic residue [active] 759364000676 Putative transcriptional regulator [Transcription]; Region: COG1678 759364000677 Uncharacterized conserved protein [Function unknown]; Region: COG1259 759364000678 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 759364000679 tetramer (dimer of dimers) interface [polypeptide binding]; other site 759364000680 active site 759364000681 dimer interface [polypeptide binding]; other site 759364000682 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 759364000683 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 759364000684 putative active site; other site 759364000685 catalytic residue [active] 759364000686 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 759364000687 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 759364000688 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 759364000689 Ligand Binding Site [chemical binding]; other site 759364000690 Predicted acid phosphatase [General function prediction only]; Region: SurE; COG0496 759364000691 prenyltransferase; Reviewed; Region: ubiA; PRK12876 759364000692 UbiA prenyltransferase family; Region: UbiA; pfam01040 759364000693 aromatic acid decarboxylase; Validated; Region: PRK05920 759364000694 Flavoprotein; Region: Flavoprotein; pfam02441 759364000695 Uncharacterized conserved protein [Function unknown]; Region: COG1284 759364000696 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 759364000697 IncA protein; Region: IncA; pfam04156 759364000698 IncA protein; Region: IncA; pfam04156 759364000699 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 759364000700 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 759364000701 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 759364000702 Na2 binding site [ion binding]; other site 759364000703 putative substrate binding site 1 [chemical binding]; other site 759364000704 Na binding site 1 [ion binding]; other site 759364000705 putative substrate binding site 2 [chemical binding]; other site 759364000706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759364000707 putative substrate translocation pore; other site 759364000708 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 759364000709 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 759364000710 ligand binding site [chemical binding]; other site 759364000711 flexible hinge region; other site 759364000712 acyl carrier protein; Provisional; Region: acpP; PRK00982 759364000713 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 759364000714 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 759364000715 NAD(P) binding site [chemical binding]; other site 759364000716 homotetramer interface [polypeptide binding]; other site 759364000717 homodimer interface [polypeptide binding]; other site 759364000718 active site 759364000719 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 759364000720 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 759364000721 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 759364000722 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 759364000723 dimer interface [polypeptide binding]; other site 759364000724 active site 759364000725 CoA binding pocket [chemical binding]; other site 759364000726 recombination protein RecR; Region: recR; TIGR00615 759364000727 RecR protein; Region: RecR; pfam02132 759364000728 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 759364000729 putative active site [active] 759364000730 putative metal-binding site [ion binding]; other site 759364000731 tetramer interface [polypeptide binding]; other site 759364000732 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 759364000733 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 759364000734 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 759364000735 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 759364000736 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 759364000737 Surface antigen; Region: Bac_surface_Ag; pfam01103 759364000738 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 759364000739 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 759364000740 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 759364000741 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 759364000742 trimer interface [polypeptide binding]; other site 759364000743 active site 759364000744 UDP-GlcNAc binding site [chemical binding]; other site 759364000745 lipid binding site [chemical binding]; lipid-binding site 759364000746 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 759364000747 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 759364000748 tetramer interface [polypeptide binding]; other site 759364000749 TPP-binding site [chemical binding]; other site 759364000750 heterodimer interface [polypeptide binding]; other site 759364000751 phosphorylation loop region [posttranslational modification] 759364000752 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 759364000753 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 759364000754 alpha subunit interface [polypeptide binding]; other site 759364000755 TPP binding site [chemical binding]; other site 759364000756 heterodimer interface [polypeptide binding]; other site 759364000757 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 759364000758 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 759364000759 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 759364000760 E3 interaction surface; other site 759364000761 lipoyl attachment site [posttranslational modification]; other site 759364000762 e3 binding domain; Region: E3_binding; pfam02817 759364000763 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 759364000764 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 759364000765 homodimer interface [polypeptide binding]; other site 759364000766 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 759364000767 active site pocket [active] 759364000768 chromosomal replication initiation protein; Provisional; Region: PRK12422 759364000769 DnaA N-terminal domain; Region: DnaA_N; pfam11638 759364000770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759364000771 Walker A motif; other site 759364000772 ATP binding site [chemical binding]; other site 759364000773 Walker B motif; other site 759364000774 arginine finger; other site 759364000775 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 759364000776 DnaA box-binding interface [nucleotide binding]; other site 759364000777 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 759364000778 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 759364000779 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 759364000780 CAAX protease self-immunity; Region: Abi; pfam02517 759364000781 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 759364000782 homodimer interface [polypeptide binding]; other site 759364000783 metal binding site [ion binding]; metal-binding site 759364000784 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 759364000785 Domain of unknown function DUF21; Region: DUF21; pfam01595 759364000786 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 759364000787 Transporter associated domain; Region: CorC_HlyC; smart01091 759364000788 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 759364000789 Domain of unknown function DUF21; Region: DUF21; pfam01595 759364000790 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 759364000791 Transporter associated domain; Region: CorC_HlyC; smart01091 759364000792 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 759364000793 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 759364000794 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 759364000795 catalytic residue [active] 759364000796 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 759364000797 Protein phosphatase 2C; Region: PP2C; pfam00481 759364000798 active site 759364000799 Uncharacterized conserved protein [Function unknown]; Region: COG5465 759364000800 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 759364000801 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 759364000802 active site 759364000803 catalytic site [active] 759364000804 substrate binding site [chemical binding]; other site 759364000805 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 759364000806 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 759364000807 nucleosidase; Provisional; Region: PRK05634 759364000808 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 759364000809 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 759364000810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759364000811 Walker A/P-loop; other site 759364000812 ATP binding site [chemical binding]; other site 759364000813 Q-loop/lid; other site 759364000814 ABC transporter signature motif; other site 759364000815 Walker B; other site 759364000816 D-loop; other site 759364000817 H-loop/switch region; other site 759364000818 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 759364000819 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 759364000820 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 759364000821 IHF - DNA interface [nucleotide binding]; other site 759364000822 IHF dimer interface [polypeptide binding]; other site 759364000823 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 759364000824 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 759364000825 active site 759364000826 metal binding site [ion binding]; metal-binding site 759364000827 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 759364000828 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 759364000829 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 759364000830 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 759364000831 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 759364000832 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 759364000833 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 759364000834 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 759364000835 MraW methylase family; Region: Methyltransf_5; pfam01795 759364000836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759364000837 TPR motif; other site 759364000838 binding surface 759364000839 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 759364000840 DnaA N-terminal domain; Region: DnaA_N; pfam11638 759364000841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759364000842 Walker A motif; other site 759364000843 ATP binding site [chemical binding]; other site 759364000844 Walker B motif; other site 759364000845 arginine finger; other site 759364000846 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 759364000847 DnaA box-binding interface [nucleotide binding]; other site 759364000848 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024 759364000849 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 759364000850 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 759364000851 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD [Energy production and conversion]; Region: NqrD; COG1347 759364000852 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061 759364000853 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 759364000854 lipoyl attachment site [posttranslational modification]; other site 759364000855 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 759364000856 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 759364000857 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 759364000858 putative active site [active] 759364000859 catalytic site [active] 759364000860 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 759364000861 putative active site [active] 759364000862 catalytic site [active] 759364000863 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 759364000864 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 759364000865 Clp amino terminal domain; Region: Clp_N; pfam02861 759364000866 Clp amino terminal domain; Region: Clp_N; pfam02861 759364000867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759364000868 Walker A motif; other site 759364000869 ATP binding site [chemical binding]; other site 759364000870 Walker B motif; other site 759364000871 arginine finger; other site 759364000872 UvrB/uvrC motif; Region: UVR; pfam02151 759364000873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759364000874 Walker A motif; other site 759364000875 ATP binding site [chemical binding]; other site 759364000876 Walker B motif; other site 759364000877 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 759364000878 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 759364000879 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 759364000880 Ligand Binding Site [chemical binding]; other site 759364000881 Helix-turn-helix domain; Region: HTH_17; pfam12728 759364000882 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 759364000883 active site 759364000884 phosphorylation site [posttranslational modification] 759364000885 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 759364000886 active site 759364000887 phosphorylation site [posttranslational modification] 759364000888 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 759364000889 trimer interface [polypeptide binding]; other site 759364000890 active site 759364000891 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 759364000892 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 759364000893 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 759364000894 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 759364000895 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 759364000896 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 759364000897 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 759364000898 active site 759364000899 substrate binding site [chemical binding]; other site 759364000900 metal binding site [ion binding]; metal-binding site 759364000901 ribonuclease III; Reviewed; Region: rnc; PRK00102 759364000902 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 759364000903 dimerization interface [polypeptide binding]; other site 759364000904 active site 759364000905 metal binding site [ion binding]; metal-binding site 759364000906 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 759364000907 dsRNA binding site [nucleotide binding]; other site 759364000908 DNA repair protein RadA; Provisional; Region: PRK11823 759364000909 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 759364000910 Walker A motif/ATP binding site; other site 759364000911 ATP binding site [chemical binding]; other site 759364000912 Walker B motif; other site 759364000913 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 759364000914 porphobilinogen deaminase; Provisional; Region: PRK01066 759364000915 Porphobilinogen deaminase, dipyromethane cofactor binding domain; Region: Porphobil_deam; pfam01379 759364000916 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 759364000917 Catalytic domain of Protein Kinases; Region: PKc; cd00180 759364000918 active site 759364000919 ATP binding site [chemical binding]; other site 759364000920 substrate binding site [chemical binding]; other site 759364000921 activation loop (A-loop); other site 759364000922 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 759364000923 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 759364000924 HIGH motif; other site 759364000925 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 759364000926 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 759364000927 active site 759364000928 KMSKS motif; other site 759364000929 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 759364000930 tRNA binding surface [nucleotide binding]; other site 759364000931 anticodon binding site; other site 759364000932 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 759364000933 V-type ATP synthase subunit K; Provisional; Region: PRK09621 759364000934 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 759364000935 V-type ATP synthase subunit I; Validated; Region: PRK05771 759364000936 Protein of unknown function (DUF1319); Region: DUF1319; pfam07028 759364000937 V-type ATP synthase subunit D; Provisional; Region: PRK02195 759364000938 V-type ATP synthase subunit B; Provisional; Region: PRK02118 759364000939 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 759364000940 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 759364000941 Walker A motif homologous position; other site 759364000942 Walker B motif; other site 759364000943 V-type ATP synthase subunit A; Provisional; Region: PRK04192 759364000944 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 759364000945 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 759364000946 Walker A motif/ATP binding site; other site 759364000947 Walker B motif; other site 759364000948 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 759364000949 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 759364000950 V-type ATP synthase subunit E; Provisional; Region: PRK01005 759364000951 V-type ATP synthase subunit E; Provisional; Region: PRK01558 759364000952 transaldolase-like protein; Provisional; Region: PTZ00411 759364000953 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 759364000954 active site 759364000955 dimer interface [polypeptide binding]; other site 759364000956 catalytic residue [active] 759364000957 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 759364000958 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 759364000959 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 759364000960 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 759364000961 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 759364000962 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 759364000963 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 759364000964 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 759364000965 DNA binding site [nucleotide binding] 759364000966 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 759364000967 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 759364000968 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 759364000969 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 759364000970 DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013 759364000971 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 759364000972 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 759364000973 RPB12 interaction site [polypeptide binding]; other site 759364000974 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 759364000975 RPB3 interaction site [polypeptide binding]; other site 759364000976 RPB1 interaction site [polypeptide binding]; other site 759364000977 RPB11 interaction site [polypeptide binding]; other site 759364000978 RPB10 interaction site [polypeptide binding]; other site 759364000979 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 759364000980 L11 interface [polypeptide binding]; other site 759364000981 putative EF-Tu interaction site [polypeptide binding]; other site 759364000982 putative EF-G interaction site [polypeptide binding]; other site 759364000983 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 759364000984 23S rRNA interface [nucleotide binding]; other site 759364000985 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 759364000986 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 759364000987 mRNA/rRNA interface [nucleotide binding]; other site 759364000988 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 759364000989 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 759364000990 putative thiostrepton binding site; other site 759364000991 23S rRNA interface [nucleotide binding]; other site 759364000992 L7/L12 interface [polypeptide binding]; other site 759364000993 L25 interface [polypeptide binding]; other site 759364000994 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 759364000995 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 759364000996 putative homodimer interface [polypeptide binding]; other site 759364000997 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 759364000998 heterodimer interface [polypeptide binding]; other site 759364000999 homodimer interface [polypeptide binding]; other site 759364001000 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 759364001001 elongation factor Tu; Reviewed; Region: PRK12735 759364001002 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 759364001003 G1 box; other site 759364001004 GEF interaction site [polypeptide binding]; other site 759364001005 GTP/Mg2+ binding site [chemical binding]; other site 759364001006 Switch I region; other site 759364001007 G2 box; other site 759364001008 G3 box; other site 759364001009 Switch II region; other site 759364001010 G4 box; other site 759364001011 G5 box; other site 759364001012 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 759364001013 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 759364001014 Antibiotic Binding Site [chemical binding]; other site 759364001015 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 759364001016 rRNA binding site [nucleotide binding]; other site 759364001017 predicted 30S ribosome binding site; other site 759364001018 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 759364001019 Protein of unknown function (DUF687); Region: DUF687; pfam05095 759364001020 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 759364001021 active site 759364001022 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 759364001023 triosephosphate isomerase; Provisional; Region: PRK14565 759364001024 substrate binding site [chemical binding]; other site 759364001025 dimer interface [polypeptide binding]; other site 759364001026 catalytic triad [active] 759364001027 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 759364001028 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 759364001029 generic binding surface II; other site 759364001030 generic binding surface I; other site 759364001031 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 759364001032 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 759364001033 TPP-binding site [chemical binding]; other site 759364001034 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 759364001035 PYR/PP interface [polypeptide binding]; other site 759364001036 dimer interface [polypeptide binding]; other site 759364001037 TPP binding site [chemical binding]; other site 759364001038 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 759364001039 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 759364001040 pyruvate kinase; Region: pyruv_kin; TIGR01064 759364001041 domain interfaces; other site 759364001042 active site 759364001043 excinuclease ABC subunit A; Provisional; Region: PRK00635 759364001044 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 759364001045 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 759364001046 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 759364001047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759364001048 Walker A/P-loop; other site 759364001049 ATP binding site [chemical binding]; other site 759364001050 Q-loop/lid; other site 759364001051 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759364001052 ABC transporter signature motif; other site 759364001053 Walker B; other site 759364001054 D-loop; other site 759364001055 H-loop/switch region; other site 759364001056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759364001057 Walker A/P-loop; other site 759364001058 ATP binding site [chemical binding]; other site 759364001059 Q-loop/lid; other site 759364001060 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759364001061 Q-loop/lid; other site 759364001062 ABC transporter signature motif; other site 759364001063 Walker B; other site 759364001064 D-loop; other site 759364001065 H-loop/switch region; other site 759364001066 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 759364001067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759364001068 Walker A motif; other site 759364001069 ATP binding site [chemical binding]; other site 759364001070 Walker B motif; other site 759364001071 arginine finger; other site 759364001072 hypothetical protein; Validated; Region: PRK00153 759364001073 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 759364001074 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 759364001075 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 759364001076 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 759364001077 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 759364001078 dimerization domain swap beta strand [polypeptide binding]; other site 759364001079 regulatory protein interface [polypeptide binding]; other site 759364001080 active site 759364001081 regulatory phosphorylation site [posttranslational modification]; other site 759364001082 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 759364001083 Competence protein; Region: Competence; pfam03772 759364001084 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 759364001085 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 759364001086 tetramer interface [polypeptide binding]; other site 759364001087 TPP-binding site [chemical binding]; other site 759364001088 heterodimer interface [polypeptide binding]; other site 759364001089 phosphorylation loop region [posttranslational modification] 759364001090 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 759364001091 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 759364001092 alpha subunit interface [polypeptide binding]; other site 759364001093 TPP binding site [chemical binding]; other site 759364001094 heterodimer interface [polypeptide binding]; other site 759364001095 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 759364001096 chaperone protein DnaJ; Provisional; Region: PRK14284 759364001097 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 759364001098 HSP70 interaction site [polypeptide binding]; other site 759364001099 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 759364001100 Zn binding sites [ion binding]; other site 759364001101 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 759364001102 dimer interface [polypeptide binding]; other site 759364001103 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 759364001104 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 759364001105 Glycoprotease family; Region: Peptidase_M22; pfam00814 759364001106 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 759364001107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759364001108 Walker A motif; other site 759364001109 ATP binding site [chemical binding]; other site 759364001110 Walker B motif; other site 759364001111 arginine finger; other site 759364001112 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 759364001113 ribonuclease Z; Region: RNase_Z; TIGR02651 759364001114 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 759364001115 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 759364001116 active site 759364001117 Int/Topo IB signature motif; other site 759364001118 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 759364001119 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 759364001120 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 759364001121 ABC transporter; Region: ABC_tran_2; pfam12848 759364001122 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 759364001123 Maf-like protein; Region: Maf; pfam02545 759364001124 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 759364001125 active site 759364001126 dimer interface [polypeptide binding]; other site 759364001127 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 759364001128 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 759364001129 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 759364001130 active site 759364001131 catalytic residues [active] 759364001132 metal binding site [ion binding]; metal-binding site 759364001133 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 759364001134 dimethyladenosine transferase; Region: ksgA; TIGR00755 759364001135 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 759364001136 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 759364001137 catalytic residues [active] 759364001138 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 759364001139 dihydrodipicolinate synthase; Region: dapA; TIGR00674 759364001140 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 759364001141 inhibitor site; inhibition site 759364001142 active site 759364001143 dimer interface [polypeptide binding]; other site 759364001144 catalytic residue [active] 759364001145 aspartate kinase; Provisional; Region: PRK05925 759364001146 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 759364001147 putative catalytic residues [active] 759364001148 nucleotide binding site [chemical binding]; other site 759364001149 aspartate binding site [chemical binding]; other site 759364001150 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 759364001151 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 759364001152 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 759364001153 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 759364001154 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 759364001155 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 759364001156 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 759364001157 hinge; other site 759364001158 active site 759364001159 shikimate kinase; Provisional; Region: PRK00625 759364001160 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 759364001161 ADP binding site [chemical binding]; other site 759364001162 magnesium binding site [ion binding]; other site 759364001163 putative shikimate binding site; other site 759364001164 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 759364001165 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 759364001166 Tetramer interface [polypeptide binding]; other site 759364001167 active site 759364001168 FMN-binding site [chemical binding]; other site 759364001169 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 759364001170 active site 759364001171 dimer interface [polypeptide binding]; other site 759364001172 metal binding site [ion binding]; metal-binding site 759364001173 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310 759364001174 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 759364001175 active site 759364001176 catalytic residue [active] 759364001177 dimer interface [polypeptide binding]; other site 759364001178 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 759364001179 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 759364001180 shikimate binding site; other site 759364001181 NAD(P) binding site [chemical binding]; other site 759364001182 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 759364001183 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 759364001184 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) [Amino acid transport and metabolism]; Region: COG1945 759364001185 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 759364001186 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 759364001187 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 759364001188 malate dehydrogenase; Provisional; Region: PRK05442 759364001189 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 759364001190 NAD(P) binding site [chemical binding]; other site 759364001191 dimer interface [polypeptide binding]; other site 759364001192 malate binding site [chemical binding]; other site 759364001193 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 759364001194 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 759364001195 active site 759364001196 dimer interface [polypeptide binding]; other site 759364001197 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 759364001198 dimer interface [polypeptide binding]; other site 759364001199 active site 759364001200 GTPases [General function prediction only]; Region: HflX; COG2262 759364001201 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 759364001202 HflX GTPase family; Region: HflX; cd01878 759364001203 G1 box; other site 759364001204 GTP/Mg2+ binding site [chemical binding]; other site 759364001205 Switch I region; other site 759364001206 G2 box; other site 759364001207 G3 box; other site 759364001208 Switch II region; other site 759364001209 G4 box; other site 759364001210 G5 box; other site 759364001211 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 759364001212 putative hydrolase; Provisional; Region: PRK02113 759364001213 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 759364001214 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 759364001215 substrate binding pocket [chemical binding]; other site 759364001216 membrane-bound complex binding site; other site 759364001217 hinge residues; other site 759364001218 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 759364001219 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 759364001220 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 759364001221 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 759364001222 nucleotide binding site/active site [active] 759364001223 Uncharacterized conserved protein related to MYG1 family [Function unknown]; Region: COG4286 759364001224 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 759364001225 hypothetical protein; Validated; Region: PRK00647 759364001226 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 759364001227 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 759364001228 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759364001229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759364001230 homodimer interface [polypeptide binding]; other site 759364001231 catalytic residue [active] 759364001232 ABC transporter substrate binding protein; Region: ABC_sub_bind; pfam04392 759364001233 prolyl-tRNA synthetase; Provisional; Region: PRK09194 759364001234 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 759364001235 dimer interface [polypeptide binding]; other site 759364001236 motif 1; other site 759364001237 active site 759364001238 motif 2; other site 759364001239 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 759364001240 putative deacylase active site [active] 759364001241 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 759364001242 active site 759364001243 motif 3; other site 759364001244 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 759364001245 anticodon binding site; other site 759364001246 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 759364001247 GrpE; Region: GrpE; pfam01025 759364001248 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 759364001249 dimer interface [polypeptide binding]; other site 759364001250 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 759364001251 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 759364001252 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 759364001253 nucleotide binding site [chemical binding]; other site 759364001254 NEF interaction site [polypeptide binding]; other site 759364001255 SBD interface [polypeptide binding]; other site 759364001256 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 759364001257 Exoribonuclease R [Transcription]; Region: VacB; COG0557 759364001258 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 759364001259 RNB domain; Region: RNB; pfam00773 759364001260 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 759364001261 Putative zinc ribbon domain; Region: DUF164; pfam02591 759364001262 KpsF/GutQ family protein; Region: kpsF; TIGR00393 759364001263 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 759364001264 putative active site [active] 759364001265 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 759364001266 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 759364001267 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 759364001268 E3 interaction surface; other site 759364001269 lipoyl attachment site [posttranslational modification]; other site 759364001270 e3 binding domain; Region: E3_binding; pfam02817 759364001271 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 759364001272 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 759364001273 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 759364001274 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 759364001275 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 759364001276 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 759364001277 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 759364001278 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 759364001279 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 759364001280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759364001281 S-adenosylmethionine binding site [chemical binding]; other site 759364001282 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 759364001283 Lumazine binding domain; Region: Lum_binding; pfam00677 759364001284 Lumazine binding domain; Region: Lum_binding; pfam00677 759364001285 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 759364001286 ATP cone domain; Region: ATP-cone; pfam03477 759364001287 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 759364001288 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 759364001289 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 759364001290 amino acid carrier protein; Region: agcS; TIGR00835 759364001291 poly(A) polymerase; Region: pcnB; TIGR01942 759364001292 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 759364001293 active site 759364001294 NTP binding site [chemical binding]; other site 759364001295 metal binding triad [ion binding]; metal-binding site 759364001296 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 759364001297 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK01021 759364001298 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 759364001299 Predicted membrane protein [Function unknown]; Region: COG3952 759364001300 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 759364001301 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 759364001302 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 759364001303 Autotransporter beta-domain; Region: Autotransporter; pfam03797 759364001304 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 759364001305 Autotransporter beta-domain; Region: Autotransporter; pfam03797 759364001306 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 759364001307 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 759364001308 Autotransporter beta-domain; Region: Autotransporter; pfam03797 759364001309 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 759364001310 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 759364001311 intersubunit interface [polypeptide binding]; other site 759364001312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759364001313 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 759364001314 Walker A/P-loop; other site 759364001315 ATP binding site [chemical binding]; other site 759364001316 Q-loop/lid; other site 759364001317 ABC transporter signature motif; other site 759364001318 Walker B; other site 759364001319 D-loop; other site 759364001320 H-loop/switch region; other site 759364001321 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 759364001322 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 759364001323 ABC-ATPase subunit interface; other site 759364001324 dimer interface [polypeptide binding]; other site 759364001325 putative PBP binding regions; other site 759364001326 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 759364001327 Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]; Region: RplU; COG0261 759364001328 Uncharacterized conserved protein [Function unknown]; Region: COG2928 759364001329 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 759364001330 FOG: CBS domain [General function prediction only]; Region: COG0517 759364001331 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 759364001332 Transporter associated domain; Region: CorC_HlyC; smart01091 759364001333 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 759364001334 anti sigma factor interaction site; other site 759364001335 regulatory phosphorylation site [posttranslational modification]; other site 759364001336 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 759364001337 hypothetical protein; Provisional; Region: PRK05926 759364001338 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759364001339 FeS/SAM binding site; other site 759364001340 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 759364001341 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 759364001342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759364001343 S-adenosylmethionine binding site [chemical binding]; other site 759364001344 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 759364001345 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 759364001346 diaminopimelate epimerase; Region: DapF; TIGR00652 759364001347 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 759364001348 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 759364001349 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 759364001350 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 759364001351 oligomer interface [polypeptide binding]; other site 759364001352 active site residues [active] 759364001353 serine hydroxymethyltransferase; Provisional; Region: PRK13580 759364001354 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 759364001355 dimer interface [polypeptide binding]; other site 759364001356 active site 759364001357 glycine-pyridoxal phosphate binding site [chemical binding]; other site 759364001358 folate binding site [chemical binding]; other site 759364001359 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 759364001360 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 759364001361 active site 759364001362 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 759364001363 homotrimer interaction site [polypeptide binding]; other site 759364001364 zinc binding site [ion binding]; other site 759364001365 CDP-binding sites; other site 759364001366 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 759364001367 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 759364001368 FAD binding pocket [chemical binding]; other site 759364001369 conserved FAD binding motif [chemical binding]; other site 759364001370 phosphate binding motif [ion binding]; other site 759364001371 beta-alpha-beta structure motif; other site 759364001372 NAD binding pocket [chemical binding]; other site 759364001373 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 759364001374 elongation factor G; Reviewed; Region: PRK12739 759364001375 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 759364001376 G1 box; other site 759364001377 putative GEF interaction site [polypeptide binding]; other site 759364001378 GTP/Mg2+ binding site [chemical binding]; other site 759364001379 Switch I region; other site 759364001380 G2 box; other site 759364001381 G3 box; other site 759364001382 Switch II region; other site 759364001383 G4 box; other site 759364001384 G5 box; other site 759364001385 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 759364001386 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 759364001387 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 759364001388 30S ribosomal protein S7; Validated; Region: PRK05302 759364001389 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 759364001390 S17 interaction site [polypeptide binding]; other site 759364001391 S8 interaction site; other site 759364001392 16S rRNA interaction site [nucleotide binding]; other site 759364001393 streptomycin interaction site [chemical binding]; other site 759364001394 23S rRNA interaction site [nucleotide binding]; other site 759364001395 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 759364001396 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 759364001397 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 759364001398 protein binding site [polypeptide binding]; other site 759364001399 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 759364001400 Catalytic dyad [active] 759364001401 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 759364001402 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA); Region: CRPA; pfam05745 759364001403 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 759364001404 Domain of unknown function DUF11; Region: DUF11; pfam01345 759364001405 Domain of unknown function DUF11; Region: DUF11; pfam01345 759364001406 Chlamydia cysteine-rich outer membrane protein 3; Region: Chlam_OMP3; pfam03503 759364001407 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 759364001408 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 759364001409 HIGH motif; other site 759364001410 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 759364001411 active site 759364001412 KMSKS motif; other site 759364001413 Helix-turn-helix domain; Region: HTH_17; pfam12728 759364001414 Helix-turn-helix domain; Region: HTH_17; pfam12728 759364001415 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 759364001416 DHH family; Region: DHH; pfam01368 759364001417 DHHA1 domain; Region: DHHA1; pfam02272 759364001418 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 759364001419 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 759364001420 Protein export membrane protein; Region: SecD_SecF; pfam02355 759364001421 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14840 759364001422 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 759364001423 catalytic residue [active] 759364001424 putative FPP diphosphate binding site; other site 759364001425 putative FPP binding hydrophobic cleft; other site 759364001426 dimer interface [polypeptide binding]; other site 759364001427 putative IPP diphosphate binding site; other site 759364001428 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 759364001429 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 759364001430 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 759364001431 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 759364001432 CMP-binding site; other site 759364001433 The sites determining sugar specificity; other site 759364001434 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 759364001435 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 759364001436 putative acyl-acceptor binding pocket; other site 759364001437 arginine-tRNA ligase; Region: PLN02286 759364001438 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 759364001439 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 759364001440 active site 759364001441 HIGH motif; other site 759364001442 KMSK motif region; other site 759364001443 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 759364001444 tRNA binding surface [nucleotide binding]; other site 759364001445 anticodon binding site; other site 759364001446 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 759364001447 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 759364001448 hinge; other site 759364001449 active site 759364001450 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 759364001451 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 759364001452 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 759364001453 DNA-binding regulatory protein, YebC/PmpR family; Region: TIGR01033 759364001454 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 759364001455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759364001456 Coenzyme A binding pocket [chemical binding]; other site 759364001457 PCRF domain; Region: PCRF; pfam03462 759364001458 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 759364001459 RF-1 domain; Region: RF-1; pfam00472 759364001460 SWIB-domain-containing proteins implicated in chromatin remodeling [Chromatin structure and dynamics]; Region: COG5531 759364001461 SWI complex, BAF60b domains; Region: SWIB; smart00151 759364001462 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 759364001463 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 759364001464 putative active site [active] 759364001465 putative metal binding site [ion binding]; other site 759364001466 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 759364001467 substrate binding site; other site 759364001468 dimer interface; other site 759364001469 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 759364001470 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 759364001471 dimerization interface 3.5A [polypeptide binding]; other site 759364001472 active site 759364001473 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 759364001474 PAS domain; Region: PAS; smart00091 759364001475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759364001476 dimer interface [polypeptide binding]; other site 759364001477 phosphorylation site [posttranslational modification] 759364001478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759364001479 ATP binding site [chemical binding]; other site 759364001480 Mg2+ binding site [ion binding]; other site 759364001481 G-X-G motif; other site 759364001482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759364001483 Response regulator receiver domain; Region: Response_reg; pfam00072 759364001484 active site 759364001485 phosphorylation site [posttranslational modification] 759364001486 intermolecular recognition site; other site 759364001487 dimerization interface [polypeptide binding]; other site 759364001488 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759364001489 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 759364001490 Walker A motif; other site 759364001491 ATP binding site [chemical binding]; other site 759364001492 Walker B motif; other site 759364001493 arginine finger; other site 759364001494 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 759364001495 Recombination protein O N terminal; Region: RecO_N; pfam11967 759364001496 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 759364001497 Recombination protein O C terminal; Region: RecO_C; pfam02565 759364001498 Uncharacterized conserved protein [Function unknown]; Region: COG1723 759364001499 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 759364001500 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 759364001501 putative tRNA-binding site [nucleotide binding]; other site 759364001502 B3/4 domain; Region: B3_4; pfam03483 759364001503 tRNA synthetase B5 domain; Region: B5; pfam03484 759364001504 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 759364001505 dimer interface [polypeptide binding]; other site 759364001506 motif 1; other site 759364001507 motif 3; other site 759364001508 motif 2; other site 759364001509 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 759364001510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 759364001511 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 759364001512 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 759364001513 DNA binding site [nucleotide binding] 759364001514 active site 759364001515 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759364001516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759364001517 dimer interface [polypeptide binding]; other site 759364001518 conserved gate region; other site 759364001519 putative PBP binding loops; other site 759364001520 ABC-ATPase subunit interface; other site 759364001521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 759364001522 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759364001523 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759364001524 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 759364001525 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 759364001526 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 759364001527 putative active site [active] 759364001528 putative metal binding site [ion binding]; other site 759364001529 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759364001530 binding surface 759364001531 TPR motif; other site 759364001532 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 759364001533 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 759364001534 C-terminal domain interface [polypeptide binding]; other site 759364001535 active site 759364001536 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 759364001537 active site 759364001538 N-terminal domain interface [polypeptide binding]; other site 759364001539 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 759364001540 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 759364001541 substrate binding pocket [chemical binding]; other site 759364001542 membrane-bound complex binding site; other site 759364001543 hinge residues; other site 759364001544 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 759364001545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759364001546 S-adenosylmethionine binding site [chemical binding]; other site 759364001547 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 759364001548 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 759364001549 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 759364001550 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 759364001551 ligand binding site; other site 759364001552 oligomer interface; other site 759364001553 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759364001554 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 759364001555 N-terminal domain interface [polypeptide binding]; other site 759364001556 sulfate 1 binding site; other site 759364001557 transcription termination factor Rho; Region: rho; TIGR00767 759364001558 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 759364001559 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 759364001560 RNA binding site [nucleotide binding]; other site 759364001561 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 759364001562 multimer interface [polypeptide binding]; other site 759364001563 Walker A motif; other site 759364001564 ATP binding site [chemical binding]; other site 759364001565 Walker B motif; other site 759364001566 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 759364001567 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 759364001568 CoA-binding site [chemical binding]; other site 759364001569 ATP-binding [chemical binding]; other site 759364001570 DNA polymerase I; Provisional; Region: PRK05755 759364001571 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 759364001572 active site 759364001573 metal binding site 1 [ion binding]; metal-binding site 759364001574 putative 5' ssDNA interaction site; other site 759364001575 metal binding site 3; metal-binding site 759364001576 metal binding site 2 [ion binding]; metal-binding site 759364001577 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 759364001578 putative DNA binding site [nucleotide binding]; other site 759364001579 putative metal binding site [ion binding]; other site 759364001580 3'-5' exonuclease; Region: 35EXOc; smart00474 759364001581 active site 759364001582 substrate binding site [chemical binding]; other site 759364001583 catalytic site [active] 759364001584 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 759364001585 active site 759364001586 DNA binding site [nucleotide binding] 759364001587 catalytic site [active] 759364001588 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 759364001589 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 759364001590 tandem repeat interface [polypeptide binding]; other site 759364001591 oligomer interface [polypeptide binding]; other site 759364001592 active site residues [active] 759364001593 TLC ATP/ADP transporter; Region: TLC; pfam03219 759364001594 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 759364001595 replicative DNA helicase; Provisional; Region: PRK06321 759364001596 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 759364001597 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 759364001598 Walker A motif; other site 759364001599 ATP binding site [chemical binding]; other site 759364001600 Walker B motif; other site 759364001601 DNA binding loops [nucleotide binding] 759364001602 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 759364001603 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 759364001604 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 759364001605 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 759364001606 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 759364001607 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 759364001608 active site 759364001609 multimer interface [polypeptide binding]; other site 759364001610 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 759364001611 RuvA N terminal domain; Region: RuvA_N; pfam01330 759364001612 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 759364001613 active site 759364001614 putative DNA-binding cleft [nucleotide binding]; other site 759364001615 dimer interface [polypeptide binding]; other site 759364001616 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 759364001617 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 759364001618 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 759364001619 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 759364001620 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 759364001621 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 759364001622 alphaNTD - beta interaction site [polypeptide binding]; other site 759364001623 alphaNTD homodimer interface [polypeptide binding]; other site 759364001624 alphaNTD - beta' interaction site [polypeptide binding]; other site 759364001625 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 759364001626 30S ribosomal protein S11; Validated; Region: PRK05309 759364001627 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 759364001628 30S ribosomal protein S13; Region: bact_S13; TIGR03631 759364001629 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 759364001630 SecY translocase; Region: SecY; pfam00344 759364001631 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 759364001632 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 759364001633 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 759364001634 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 759364001635 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 759364001636 5S rRNA interface [nucleotide binding]; other site 759364001637 23S rRNA interface [nucleotide binding]; other site 759364001638 L5 interface [polypeptide binding]; other site 759364001639 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 759364001640 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 759364001641 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 759364001642 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 759364001643 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 759364001644 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 759364001645 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 759364001646 Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Region: RplX; COG0198 759364001647 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 759364001648 RNA binding site [nucleotide binding]; other site 759364001649 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 759364001650 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 759364001651 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 759364001652 23S rRNA interface [nucleotide binding]; other site 759364001653 putative translocon interaction site; other site 759364001654 signal recognition particle (SRP54) interaction site; other site 759364001655 L23 interface [polypeptide binding]; other site 759364001656 trigger factor interaction site; other site 759364001657 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 759364001658 23S rRNA interface [nucleotide binding]; other site 759364001659 5S rRNA interface [nucleotide binding]; other site 759364001660 putative antibiotic binding site [chemical binding]; other site 759364001661 L25 interface [polypeptide binding]; other site 759364001662 L27 interface [polypeptide binding]; other site 759364001663 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 759364001664 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 759364001665 G-X-X-G motif; other site 759364001666 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 759364001667 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 759364001668 putative translocon binding site; other site 759364001669 protein-rRNA interface [nucleotide binding]; other site 759364001670 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 759364001671 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 759364001672 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 759364001673 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 759364001674 Ribosomal protein L23 [Translation, ribosomal structure and biogenesis]; Region: RplW; COG0089 759364001675 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 759364001676 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 759364001677 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 759364001678 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 759364001679 putative active site [active] 759364001680 substrate binding site [chemical binding]; other site 759364001681 putative cosubstrate binding site; other site 759364001682 catalytic site [active] 759364001683 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 759364001684 substrate binding site [chemical binding]; other site 759364001685 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 759364001686 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 759364001687 active site 759364001688 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 759364001689 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 759364001690 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 759364001691 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 759364001692 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 759364001693 putative active site [active] 759364001694 catalytic triad [active] 759364001695 putative dimer interface [polypeptide binding]; other site 759364001696 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 759364001697 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 759364001698 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 759364001699 active site 759364001700 catalytic site [active] 759364001701 substrate binding site [chemical binding]; other site 759364001702 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 759364001703 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 759364001704 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 759364001705 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 759364001706 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 759364001707 catalytic residues [active] 759364001708 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 759364001709 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 759364001710 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 759364001711 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 759364001712 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 759364001713 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 759364001714 dimer interface [polypeptide binding]; other site 759364001715 anticodon binding site; other site 759364001716 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 759364001717 homodimer interface [polypeptide binding]; other site 759364001718 motif 1; other site 759364001719 active site 759364001720 motif 2; other site 759364001721 GAD domain; Region: GAD; pfam02938 759364001722 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 759364001723 active site 759364001724 motif 3; other site 759364001725 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 759364001726 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 759364001727 dimer interface [polypeptide binding]; other site 759364001728 motif 1; other site 759364001729 active site 759364001730 motif 2; other site 759364001731 motif 3; other site 759364001732 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 759364001733 anticodon binding site; other site 759364001734 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 759364001735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759364001736 putative substrate translocation pore; other site 759364001737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759364001738 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 759364001739 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 759364001740 active site 759364001741 PHP Thumb interface [polypeptide binding]; other site 759364001742 metal binding site [ion binding]; metal-binding site 759364001743 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 759364001744 generic binding surface I; other site 759364001745 generic binding surface II; other site 759364001746 TPR repeat; Region: TPR_11; pfam13414 759364001747 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759364001748 binding surface 759364001749 TPR motif; other site 759364001750 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 759364001751 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 759364001752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 759364001753 Mg2+ binding site [ion binding]; other site 759364001754 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 759364001755 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 759364001756 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 759364001757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759364001758 S-adenosylmethionine binding site [chemical binding]; other site 759364001759 branched-chain amino acid uptake carrier; Region: livcs; TIGR00796 759364001760 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 759364001761 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759364001762 ATP binding site [chemical binding]; other site 759364001763 putative Mg++ binding site [ion binding]; other site 759364001764 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759364001765 ATP-binding site [chemical binding]; other site 759364001766 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 759364001767 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 759364001768 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 759364001769 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 759364001770 lipoate synthase; Region: lipA; TIGR00510 759364001771 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759364001772 FeS/SAM binding site; other site 759364001773 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 759364001774 type III secretion system protein; Validated; Region: PRK06328 759364001775 Flagellar assembly protein FliH; Region: FliH; pfam02108 759364001776 type III secretion system protein; Reviewed; Region: PRK09617 759364001777 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 759364001778 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 759364001779 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 759364001780 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 759364001781 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 759364001782 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 759364001783 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 759364001784 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 759364001785 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 759364001786 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 759364001787 Walker A motif; other site 759364001788 ATP binding site [chemical binding]; other site 759364001789 Walker B motif; other site 759364001790 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 759364001791 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 759364001792 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 759364001793 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 759364001794 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 759364001795 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 759364001796 active site 759364001797 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 759364001798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759364001799 ATP binding site [chemical binding]; other site 759364001800 Mg2+ binding site [ion binding]; other site 759364001801 G-X-G motif; other site 759364001802 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 759364001803 ATP binding site [chemical binding]; other site 759364001804 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 759364001805 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 759364001806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759364001807 binding surface 759364001808 TPR motif; other site 759364001809 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 759364001810 EamA-like transporter family; Region: EamA; pfam00892 759364001811 EamA-like transporter family; Region: EamA; pfam00892 759364001812 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 759364001813 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cd01616 759364001814 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 759364001815 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 759364001816 active site 759364001817 dimer interface [polypeptide binding]; other site 759364001818 motif 1; other site 759364001819 motif 2; other site 759364001820 motif 3; other site 759364001821 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 759364001822 anticodon binding site; other site 759364001823 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 759364001824 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 759364001825 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 759364001826 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 759364001827 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 759364001828 active site 759364001829 HIGH motif; other site 759364001830 dimer interface [polypeptide binding]; other site 759364001831 KMSKS motif; other site 759364001832 excinuclease ABC subunit B; Provisional; Region: PRK05298 759364001833 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759364001834 ATP binding site [chemical binding]; other site 759364001835 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759364001836 nucleotide binding region [chemical binding]; other site 759364001837 ATP-binding site [chemical binding]; other site 759364001838 Ultra-violet resistance protein B; Region: UvrB; pfam12344 759364001839 enolase; Provisional; Region: eno; PRK00077 759364001840 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 759364001841 dimer interface [polypeptide binding]; other site 759364001842 metal binding site [ion binding]; metal-binding site 759364001843 substrate binding pocket [chemical binding]; other site 759364001844 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 759364001845 HAMP domain; Region: HAMP; pfam00672 759364001846 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 759364001847 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 759364001848 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 759364001849 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 759364001850 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 759364001851 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 759364001852 L-aspartate oxidase; Provisional; Region: PRK06175 759364001853 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 759364001854 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 759364001855 Iron-sulfur protein interface; other site 759364001856 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 759364001857 proximal heme binding site [chemical binding]; other site 759364001858 Iron-sulfur protein interface; other site 759364001859 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 759364001860 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 759364001861 active site 759364001862 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 759364001863 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 759364001864 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 759364001865 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 759364001866 DsbD alpha interface [polypeptide binding]; other site 759364001867 catalytic residues [active] 759364001868 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 759364001869 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 759364001870 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 759364001871 translocation protein TolB; Provisional; Region: tolB; PRK01029 759364001872 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 759364001873 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 759364001874 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 759364001875 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 759364001876 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 759364001877 ligand binding site [chemical binding]; other site 759364001878 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 759364001879 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 759364001880 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 759364001881 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 759364001882 dimer interface [polypeptide binding]; other site 759364001883 decamer (pentamer of dimers) interface [polypeptide binding]; other site 759364001884 catalytic triad [active] 759364001885 peroxidatic and resolving cysteines [active] 759364001886 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 759364001887 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 759364001888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 759364001889 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 759364001890 active site 759364001891 dimerization interface [polypeptide binding]; other site 759364001892 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 759364001893 ligand binding site [chemical binding]; other site 759364001894 active site 759364001895 UGI interface [polypeptide binding]; other site 759364001896 catalytic site [active] 759364001897 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 759364001898 Part of AAA domain; Region: AAA_19; pfam13245 759364001899 Family description; Region: UvrD_C_2; pfam13538 759364001900 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 759364001901 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 759364001902 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 759364001903 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 759364001904 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 759364001905 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 759364001906 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 759364001907 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 759364001908 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 759364001909 folate binding site [chemical binding]; other site 759364001910 NADP+ binding site [chemical binding]; other site 759364001911 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 759364001912 catalytic center binding site [active] 759364001913 ATP binding site [chemical binding]; other site 759364001914 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 759364001915 dihydropteroate synthase; Region: DHPS; TIGR01496 759364001916 substrate binding pocket [chemical binding]; other site 759364001917 dimer interface [polypeptide binding]; other site 759364001918 inhibitor binding site; inhibition site 759364001919 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 759364001920 homooctamer interface [polypeptide binding]; other site 759364001921 active site 759364001922 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 759364001923 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 759364001924 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 759364001925 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 759364001926 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 759364001927 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 759364001928 DNA binding residues [nucleotide binding] 759364001929 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 759364001930 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 759364001931 Effector from type III secretion system; Region: Effector_1; pfam04518 759364001932 Effector from type III secretion system; Region: Effector_1; pfam04518 759364001933 Effector from type III secretion system; Region: Effector_1; pfam04518 759364001934 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 759364001935 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 759364001936 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 759364001937 MviN-like protein; Region: MVIN; pfam03023 759364001938 endonuclease IV; Provisional; Region: PRK01060 759364001939 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 759364001940 AP (apurinic/apyrimidinic) site pocket; other site 759364001941 DNA interaction; other site 759364001942 Metal-binding active site; metal-binding site 759364001943 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 759364001944 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 759364001945 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 759364001946 RNA binding surface [nucleotide binding]; other site 759364001947 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 759364001948 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 759364001949 active site residue [active] 759364001950 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 759364001951 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 759364001952 substrate binding pocket [chemical binding]; other site 759364001953 chain length determination region; other site 759364001954 substrate-Mg2+ binding site; other site 759364001955 catalytic residues [active] 759364001956 aspartate-rich region 1; other site 759364001957 active site lid residues [active] 759364001958 aspartate-rich region 2; other site 759364001959 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 759364001960 putative trimer interface [polypeptide binding]; other site 759364001961 putative CoA binding site [chemical binding]; other site 759364001962 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 759364001963 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 759364001964 DNA binding site [nucleotide binding] 759364001965 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 759364001966 Thymidylate synthase complementing protein; Region: Thy1; cl03630 759364001967 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 759364001968 dimer interface [polypeptide binding]; other site 759364001969 active site 759364001970 aspartate-rich active site metal binding site; other site 759364001971 allosteric magnesium binding site [ion binding]; other site 759364001972 Schiff base residues; other site 759364001973 NADH:ubiquinone oxidoreductase, Na(+)-translocating, A subunit; Region: nqrA; TIGR01936 759364001974 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 759364001975 transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330 759364001976 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 759364001977 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 759364001978 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 759364001979 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759364001980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759364001981 homodimer interface [polypeptide binding]; other site 759364001982 catalytic residue [active] 759364001983 rod shape-determining protein MreC; Provisional; Region: PRK14872 759364001984 rod shape-determining protein MreC; Region: MreC; pfam04085 759364001985 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 759364001986 Part of AAA domain; Region: AAA_19; pfam13245 759364001987 Family description; Region: UvrD_C_2; pfam13538 759364001988 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 759364001989 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759364001990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759364001991 putative substrate translocation pore; other site 759364001992 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 759364001993 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 759364001994 active site 759364001995 interdomain interaction site; other site 759364001996 putative metal-binding site [ion binding]; other site 759364001997 nucleotide binding site [chemical binding]; other site 759364001998 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 759364001999 domain I; other site 759364002000 DNA binding groove [nucleotide binding] 759364002001 phosphate binding site [ion binding]; other site 759364002002 domain II; other site 759364002003 domain III; other site 759364002004 nucleotide binding site [chemical binding]; other site 759364002005 catalytic site [active] 759364002006 domain IV; other site 759364002007 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 759364002008 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 759364002009 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 759364002010 SWI complex, BAF60b domains; Region: SWIB; smart00151 759364002011 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 759364002012 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 759364002013 FMN binding site [chemical binding]; other site 759364002014 active site 759364002015 catalytic residues [active] 759364002016 substrate binding site [chemical binding]; other site 759364002017 Predicted integral membrane protein [Function unknown]; Region: COG0762 759364002018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 759364002019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 759364002020 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 759364002021 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 759364002022 recombinase A; Provisional; Region: recA; PRK09354 759364002023 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 759364002024 hexamer interface [polypeptide binding]; other site 759364002025 Walker A motif; other site 759364002026 ATP binding site [chemical binding]; other site 759364002027 Walker B motif; other site 759364002028 Protein of unknown function (DUF1347); Region: DUF1347; pfam07079 759364002029 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 759364002030 AAA domain; Region: AAA_30; pfam13604 759364002031 Family description; Region: UvrD_C_2; pfam13538 759364002032 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 759364002033 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 759364002034 Walker A/P-loop; other site 759364002035 ATP binding site [chemical binding]; other site 759364002036 Q-loop/lid; other site 759364002037 ABC transporter signature motif; other site 759364002038 Walker B; other site 759364002039 D-loop; other site 759364002040 H-loop/switch region; other site 759364002041 Protein of unknown function (DUF1137); Region: DUF1137; pfam06587 759364002042 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 759364002043 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 759364002044 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 759364002045 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 759364002046 RNA binding surface [nucleotide binding]; other site 759364002047 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 759364002048 active site 759364002049 hypothetical protein; Provisional; Region: PRK01064 759364002050 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 759364002051 DNA topoisomerase IV subunit A; Provisional; Region: PRK09630 759364002052 DNA Topoisomerase IV; Region: TOP4c; smart00434 759364002053 CAP-like domain; other site 759364002054 active site 759364002055 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 759364002056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759364002057 ATP binding site [chemical binding]; other site 759364002058 Mg2+ binding site [ion binding]; other site 759364002059 G-X-G motif; other site 759364002060 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 759364002061 ATP binding site [chemical binding]; other site 759364002062 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 759364002063 active site 759364002064 putative metal-binding site [ion binding]; other site 759364002065 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 759364002066 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 759364002067 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 759364002068 NAD(P) binding pocket [chemical binding]; other site 759364002069 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 759364002070 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 759364002071 phosphopeptide binding site; other site 759364002072 MARCKS family; Region: MARCKS; pfam02063 759364002073 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 759364002074 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 759364002075 phosphopeptide binding site; other site 759364002076 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 759364002077 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 759364002078 binding surface 759364002079 Tetratricopeptide repeat; Region: TPR_16; pfam13432 759364002080 TPR motif; other site 759364002081 type III secretion system ATPase; Provisional; Region: PRK06315 759364002082 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 759364002083 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 759364002084 Walker A motif/ATP binding site; other site 759364002085 Walker B motif; other site 759364002086 type III secretion system protein; Validated; Region: PRK05933 759364002087 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 759364002088 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 759364002089 Catalytic domain of Protein Kinases; Region: PKc; cd00180 759364002090 active site 759364002091 ATP binding site [chemical binding]; other site 759364002092 substrate binding site [chemical binding]; other site 759364002093 activation loop (A-loop); other site 759364002094 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 759364002095 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 759364002096 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 759364002097 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 759364002098 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 759364002099 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 759364002100 ADP binding site [chemical binding]; other site 759364002101 phosphagen binding site; other site 759364002102 substrate specificity loop; other site 759364002103 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 759364002104 UvrB/uvrC motif; Region: UVR; pfam02151 759364002105 ribosome recycling factor; Reviewed; Region: frr; PRK00083 759364002106 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 759364002107 hinge region; other site 759364002108 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 759364002109 putative nucleotide binding site [chemical binding]; other site 759364002110 uridine monophosphate binding site [chemical binding]; other site 759364002111 homohexameric interface [polypeptide binding]; other site 759364002112 Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]; Region: Tsf; COG0264 759364002113 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 759364002114 Elongation factor TS; Region: EF_TS; pfam00889 759364002115 Elongation factor TS; Region: EF_TS; pfam00889 759364002116 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 759364002117 rRNA interaction site [nucleotide binding]; other site 759364002118 S8 interaction site; other site 759364002119 putative laminin-1 binding site; other site 759364002120 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 759364002121 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 759364002122 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 759364002123 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 759364002124 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 759364002125 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759364002126 TPR motif; other site 759364002127 Tetratricopeptide repeat; Region: TPR_16; pfam13432 759364002128 binding surface 759364002129 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759364002130 binding surface 759364002131 TPR motif; other site 759364002132 TPR repeat; Region: TPR_11; pfam13414 759364002133 TPR repeat; Region: TPR_11; pfam13414 759364002134 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759364002135 binding surface 759364002136 TPR motif; other site 759364002137 TPR repeat; Region: TPR_11; pfam13414 759364002138 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 759364002139 putative ABC transporter; Region: ycf24; CHL00085 759364002140 FeS assembly ATPase SufC; Region: sufC; TIGR01978 759364002141 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 759364002142 Walker A/P-loop; other site 759364002143 ATP binding site [chemical binding]; other site 759364002144 Q-loop/lid; other site 759364002145 ABC transporter signature motif; other site 759364002146 Walker B; other site 759364002147 D-loop; other site 759364002148 H-loop/switch region; other site 759364002149 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 759364002150 FeS assembly protein SufD; Region: sufD; TIGR01981 759364002151 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 759364002152 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 759364002153 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 759364002154 catalytic residue [active] 759364002155 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 759364002156 ParB-like nuclease domain; Region: ParBc; pfam02195 759364002157 KorB domain; Region: KorB; pfam08535 759364002158 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759364002159 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 759364002160 Walker A/P-loop; other site 759364002161 ATP binding site [chemical binding]; other site 759364002162 Q-loop/lid; other site 759364002163 ABC transporter signature motif; other site 759364002164 Walker B; other site 759364002165 D-loop; other site 759364002166 H-loop/switch region; other site 759364002167 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759364002168 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 759364002169 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759364002170 Walker A/P-loop; other site 759364002171 ATP binding site [chemical binding]; other site 759364002172 Q-loop/lid; other site 759364002173 ABC transporter signature motif; other site 759364002174 Walker B; other site 759364002175 D-loop; other site 759364002176 H-loop/switch region; other site 759364002177 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759364002178 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 759364002179 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 759364002180 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 759364002181 Phosphoglycerate kinase; Region: PGK; pfam00162 759364002182 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 759364002183 substrate binding site [chemical binding]; other site 759364002184 hinge regions; other site 759364002185 ADP binding site [chemical binding]; other site 759364002186 catalytic site [active] 759364002187 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 759364002188 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 759364002189 minor groove reading motif; other site 759364002190 helix-hairpin-helix signature motif; other site 759364002191 substrate binding pocket [chemical binding]; other site 759364002192 active site 759364002193 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 759364002194 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 759364002195 trmE is a tRNA modification GTPase; Region: trmE; cd04164 759364002196 G1 box; other site 759364002197 GTP/Mg2+ binding site [chemical binding]; other site 759364002198 Switch I region; other site 759364002199 G2 box; other site 759364002200 Switch II region; other site 759364002201 G3 box; other site 759364002202 G4 box; other site 759364002203 G5 box; other site 759364002204 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 759364002205 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 759364002206 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759364002207 binding surface 759364002208 TPR motif; other site 759364002209 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 759364002210 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 759364002211 ATP binding site [chemical binding]; other site 759364002212 putative Mg++ binding site [ion binding]; other site 759364002213 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 759364002214 Predicted GTPases [General function prediction only]; Region: COG1160 759364002215 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 759364002216 G1 box; other site 759364002217 GTP/Mg2+ binding site [chemical binding]; other site 759364002218 Switch I region; other site 759364002219 G2 box; other site 759364002220 Switch II region; other site 759364002221 G3 box; other site 759364002222 G4 box; other site 759364002223 G5 box; other site 759364002224 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 759364002225 G1 box; other site 759364002226 GTP/Mg2+ binding site [chemical binding]; other site 759364002227 Switch I region; other site 759364002228 G2 box; other site 759364002229 G3 box; other site 759364002230 Switch II region; other site 759364002231 G4 box; other site 759364002232 G5 box; other site 759364002233 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 759364002234 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 759364002235 active site 759364002236 NTP binding site [chemical binding]; other site 759364002237 metal binding triad [ion binding]; metal-binding site 759364002238 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 759364002239 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 759364002240 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 759364002241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759364002242 Walker A motif; other site 759364002243 ATP binding site [chemical binding]; other site 759364002244 Walker B motif; other site 759364002245 arginine finger; other site 759364002246 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 759364002247 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 759364002248 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 759364002249 oligomer interface [polypeptide binding]; other site 759364002250 active site residues [active] 759364002251 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 759364002252 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 759364002253 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 759364002254 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 759364002255 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759364002256 ATP binding site [chemical binding]; other site 759364002257 putative Mg++ binding site [ion binding]; other site 759364002258 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759364002259 nucleotide binding region [chemical binding]; other site 759364002260 ATP-binding site [chemical binding]; other site 759364002261 rod shape-determining protein MreB; Provisional; Region: PRK13927 759364002262 MreB and similar proteins; Region: MreB_like; cd10225 759364002263 nucleotide binding site [chemical binding]; other site 759364002264 Mg binding site [ion binding]; other site 759364002265 putative protofilament interaction site [polypeptide binding]; other site 759364002266 RodZ interaction site [polypeptide binding]; other site 759364002267 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 759364002268 active site 759364002269 substrate-binding site [chemical binding]; other site 759364002270 metal-binding site [ion binding] 759364002271 GTP binding site [chemical binding]; other site 759364002272 Effector from type III secretion system; Region: Effector_1; pfam04518 759364002273 Effector from type III secretion system; Region: Effector_1; pfam04518 759364002274 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 759364002275 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 759364002276 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 759364002277 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 759364002278 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 759364002279 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759364002280 active site 759364002281 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 759364002282 type III secretion system ATPase; Validated; Region: PRK05922 759364002283 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 759364002284 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 759364002285 Walker A motif; other site 759364002286 ATP binding site [chemical binding]; other site 759364002287 Walker B motif; other site 759364002288 type III secretion system protein; Validated; Region: PRK05934 759364002289 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 759364002290 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 759364002291 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 759364002292 active site 759364002293 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 759364002294 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 759364002295 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 759364002296 catalytic residue [active] 759364002297 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 759364002298 catalytic core [active] 759364002299 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 759364002300 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 759364002301 RNA binding surface [nucleotide binding]; other site 759364002302 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 759364002303 active site 759364002304 biotin--protein ligase; Provisional; Region: PRK05935 759364002305 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 759364002306 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 759364002307 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 759364002308 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 759364002309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759364002310 motif II; other site 759364002311 CCC1-related protein family; Region: CCC1_like_1; cd02437 759364002312 seryl-tRNA synthetase; Provisional; Region: PRK05431 759364002313 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 759364002314 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 759364002315 dimer interface [polypeptide binding]; other site 759364002316 active site 759364002317 motif 1; other site 759364002318 motif 2; other site 759364002319 motif 3; other site 759364002320 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 759364002321 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 759364002322 catalytic motif [active] 759364002323 Zn binding site [ion binding]; other site 759364002324 RibD C-terminal domain; Region: RibD_C; pfam01872 759364002325 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 759364002326 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 759364002327 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 759364002328 dimerization interface [polypeptide binding]; other site 759364002329 active site 759364002330 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 759364002331 homopentamer interface [polypeptide binding]; other site 759364002332 active site 759364002333 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 759364002334 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 759364002335 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 759364002336 substrate binding site [chemical binding]; other site 759364002337 Proteins containing SET domain [General function prediction only]; Region: COG2940 759364002338 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 759364002339 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 759364002340 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 759364002341 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 759364002342 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 759364002343 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 759364002344 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Region: NqrF; COG2871 759364002345 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 759364002346 catalytic loop [active] 759364002347 iron binding site [ion binding]; other site 759364002348 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 759364002349 FAD binding pocket [chemical binding]; other site 759364002350 FAD binding motif [chemical binding]; other site 759364002351 phosphate binding motif [ion binding]; other site 759364002352 beta-alpha-beta structure motif; other site 759364002353 NAD binding pocket [chemical binding]; other site 759364002354 preprotein translocase, YajC subunit; Region: yajC; TIGR00739 759364002355 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 759364002356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759364002357 S-adenosylmethionine binding site [chemical binding]; other site 759364002358 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759364002359 binding surface 759364002360 TPR motif; other site 759364002361 Tetratricopeptide repeat; Region: TPR_12; pfam13424 759364002362 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 759364002363 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 759364002364 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 759364002365 HemN C-terminal domain; Region: HemN_C; pfam06969 759364002366 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 759364002367 substrate binding site [chemical binding]; other site 759364002368 active site 759364002369 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 759364002370 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 759364002371 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759364002372 ATP binding site [chemical binding]; other site 759364002373 putative Mg++ binding site [ion binding]; other site 759364002374 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759364002375 nucleotide binding region [chemical binding]; other site 759364002376 ATP-binding site [chemical binding]; other site 759364002377 TRCF domain; Region: TRCF; pfam03461 759364002378 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 759364002379 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 759364002380 motif 1; other site 759364002381 active site 759364002382 motif 2; other site 759364002383 motif 3; other site 759364002384 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 759364002385 DHHA1 domain; Region: DHHA1; pfam02272 759364002386 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 759364002387 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 759364002388 TPP-binding site [chemical binding]; other site 759364002389 dimer interface [polypeptide binding]; other site 759364002390 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 759364002391 PYR/PP interface [polypeptide binding]; other site 759364002392 dimer interface [polypeptide binding]; other site 759364002393 TPP binding site [chemical binding]; other site 759364002394 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 759364002395 AMP nucleosidase, putative; Region: AMN-like; TIGR01721 759364002396 elongation factor P; Validated; Region: PRK00529 759364002397 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 759364002398 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 759364002399 RNA binding site [nucleotide binding]; other site 759364002400 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 759364002401 RNA binding site [nucleotide binding]; other site 759364002402 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 759364002403 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 759364002404 putative active site [active] 759364002405 putative metal binding site [ion binding]; other site 759364002406 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 759364002407 active site 759364002408 metal binding site [ion binding]; metal-binding site 759364002409 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 759364002410 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 759364002411 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 759364002412 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 759364002413 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 759364002414 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 759364002415 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 759364002416 Mg++ binding site [ion binding]; other site 759364002417 putative catalytic motif [active] 759364002418 putative substrate binding site [chemical binding]; other site 759364002419 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683 759364002420 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 759364002421 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 759364002422 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 759364002423 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 759364002424 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 759364002425 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 759364002426 cell division protein FtsW; Region: ftsW; TIGR02614 759364002427 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 759364002428 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 759364002429 active site 759364002430 homodimer interface [polypeptide binding]; other site 759364002431 bifunctional D-alanyl-alanine synthetase A/UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: PRK14573 759364002432 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 759364002433 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 759364002434 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 759364002435 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 759364002436 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 759364002437 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 759364002438 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cd02409 759364002439 G-X-X-G motif; other site 759364002440 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 759364002441 anti sigma factor interaction site; other site 759364002442 regulatory phosphorylation site [posttranslational modification]; other site 759364002443 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 759364002444 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 759364002445 hypothetical protein; Provisional; Region: PRK05927 759364002446 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759364002447 FeS/SAM binding site; other site 759364002448 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 759364002449 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 759364002450 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 759364002451 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 759364002452 dimer interface [polypeptide binding]; other site 759364002453 active site 759364002454 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 759364002455 active site 759364002456 Ap4A binding cleft/pocket [chemical binding]; other site 759364002457 P4 phosphate binding site; other site 759364002458 nudix motif; other site 759364002459 putative P2/P3 phosphate binding site [ion binding]; other site 759364002460 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 759364002461 dimer interface [polypeptide binding]; other site 759364002462 substrate binding site [chemical binding]; other site 759364002463 metal binding sites [ion binding]; metal-binding site 759364002464 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 759364002465 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 759364002466 active site 759364002467 putative lithium-binding site [ion binding]; other site 759364002468 substrate binding site [chemical binding]; other site 759364002469 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 759364002470 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 759364002471 putative acyl-acceptor binding pocket; other site 759364002472 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 759364002473 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 759364002474 acyl-activating enzyme (AAE) consensus motif; other site 759364002475 AMP binding site [chemical binding]; other site 759364002476 active site 759364002477 CoA binding site [chemical binding]; other site 759364002478 8-amino-7-oxononanoate synthase; Provisional; Region: PRK05937 759364002479 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 759364002480 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 759364002481 catalytic residue [active] 759364002482 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 759364002483 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 759364002484 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 759364002485 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 759364002486 dimer interface [polypeptide binding]; other site 759364002487 putative anticodon binding site; other site 759364002488 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 759364002489 motif 1; other site 759364002490 dimer interface [polypeptide binding]; other site 759364002491 active site 759364002492 motif 2; other site 759364002493 motif 3; other site 759364002494 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 759364002495 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 759364002496 active site 759364002497 HIGH motif; other site 759364002498 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 759364002499 KMSKS motif; other site 759364002500 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 759364002501 tRNA binding surface [nucleotide binding]; other site 759364002502 anticodon binding site; other site 759364002503 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 759364002504 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 759364002505 ribonuclease P; Reviewed; Region: rnpA; PRK00730 759364002506 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 759364002507 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 759364002508 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 759364002509 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 759364002510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 759364002511 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 759364002512 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 759364002513 GIY-YIG motif/motif A; other site 759364002514 active site 759364002515 catalytic site [active] 759364002516 putative DNA binding site [nucleotide binding]; other site 759364002517 metal binding site [ion binding]; metal-binding site 759364002518 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 759364002519 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 759364002520 MutS domain I; Region: MutS_I; pfam01624 759364002521 MutS domain II; Region: MutS_II; pfam05188 759364002522 MutS domain III; Region: MutS_III; pfam05192 759364002523 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 759364002524 Walker A/P-loop; other site 759364002525 ATP binding site [chemical binding]; other site 759364002526 Q-loop/lid; other site 759364002527 ABC transporter signature motif; other site 759364002528 Walker B; other site 759364002529 D-loop; other site 759364002530 H-loop/switch region; other site 759364002531 DNA primase; Validated; Region: dnaG; PRK05667 759364002532 CHC2 zinc finger; Region: zf-CHC2; pfam01807 759364002533 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 759364002534 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 759364002535 active site 759364002536 metal binding site [ion binding]; metal-binding site 759364002537 interdomain interaction site; other site 759364002538 glycyl-tRNA synthetase; Provisional; Region: PRK14908 759364002539 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 759364002540 dimer interface [polypeptide binding]; other site 759364002541 motif 1; other site 759364002542 active site 759364002543 motif 2; other site 759364002544 motif 3; other site 759364002545 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 759364002546 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 759364002547 glycogen synthase; Provisional; Region: glgA; PRK00654 759364002548 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 759364002549 ADP-binding pocket [chemical binding]; other site 759364002550 homodimer interface [polypeptide binding]; other site 759364002551 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 759364002552 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 759364002553 5S rRNA interface [nucleotide binding]; other site 759364002554 CTC domain interface [polypeptide binding]; other site 759364002555 L16 interface [polypeptide binding]; other site 759364002556 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 759364002557 putative active site [active] 759364002558 catalytic residue [active] 759364002559 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 759364002560 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 759364002561 Ribosomal protein L9 [Translation, ribosomal structure and biogenesis]; Region: RplI; COG0359 759364002562 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 759364002563 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 759364002564 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK00650 759364002565 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 759364002566 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 759364002567 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 759364002568 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 759364002569 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 759364002570 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 759364002571 putative acyl-acceptor binding pocket; other site 759364002572 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 759364002573 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 759364002574 homodimer interface [polypeptide binding]; other site 759364002575 oligonucleotide binding site [chemical binding]; other site 759364002576 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 759364002577 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13846 759364002578 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 759364002579 Autotransporter beta-domain; Region: Autotransporter; pfam03797 759364002580 IncA protein; Region: IncA; pfam04156 759364002581 YtxH-like protein; Region: YtxH; pfam12732 759364002582 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 759364002583 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 759364002584 active site 759364002585 substrate binding site [chemical binding]; other site 759364002586 metal binding site [ion binding]; metal-binding site 759364002587 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 759364002588 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 759364002589 glutaminase active site [active] 759364002590 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 759364002591 dimer interface [polypeptide binding]; other site 759364002592 active site 759364002593 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 759364002594 dimer interface [polypeptide binding]; other site 759364002595 active site 759364002596 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 759364002597 aromatic amino acid transport protein; Region: araaP; TIGR00837 759364002598 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 759364002599 aromatic amino acid transport protein; Region: araaP; TIGR00837 759364002600 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 759364002601 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 759364002602 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 759364002603 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 759364002604 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 759364002605 succinyl-CoA synthetase, beta subunit; Region: sucCoAbeta; TIGR01016 759364002606 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 759364002607 CoA-ligase; Region: Ligase_CoA; pfam00549 759364002608 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 759364002609 CoA binding domain; Region: CoA_binding; smart00881 759364002610 CoA-ligase; Region: Ligase_CoA; pfam00549 759364002611 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 759364002612 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 759364002613 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 759364002614 protein binding site [polypeptide binding]; other site 759364002615 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 759364002616 protein binding site [polypeptide binding]; other site 759364002617 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 759364002618 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 759364002619 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 759364002620 Peptidase M16C associated; Region: M16C_assoc; pfam08367 759364002621 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 759364002622 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 759364002623 RmuC family; Region: RmuC; pfam02646 759364002624 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 759364002625 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 759364002626 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365 759364002627 ATP cone domain; Region: ATP-cone; pfam03477 759364002628 ATP cone domain; Region: ATP-cone; pfam03477 759364002629 Class I ribonucleotide reductase; Region: RNR_I; cd01679 759364002630 active site 759364002631 dimer interface [polypeptide binding]; other site 759364002632 catalytic residues [active] 759364002633 effector binding site; other site 759364002634 R2 peptide binding site; other site 759364002635 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 759364002636 dimer interface [polypeptide binding]; other site 759364002637 putative radical transfer pathway; other site 759364002638 diiron center [ion binding]; other site 759364002639 tyrosyl radical; other site 759364002640 Putative methyltransferase; Region: Methyltransf_4; pfam02390 759364002641 Methyltransferase domain; Region: Methyltransf_18; pfam12847 759364002642 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 759364002643 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 759364002644 FAD binding domain; Region: FAD_binding_4; pfam01565 759364002645 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 759364002646 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 759364002647 putative RNA binding site [nucleotide binding]; other site 759364002648 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 759364002649 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 759364002650 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 759364002651 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 759364002652 23S rRNA binding site [nucleotide binding]; other site 759364002653 L21 binding site [polypeptide binding]; other site 759364002654 L13 binding site [polypeptide binding]; other site 759364002655 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 759364002656 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 759364002657 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 759364002658 motif 1; other site 759364002659 dimer interface [polypeptide binding]; other site 759364002660 active site 759364002661 motif 2; other site 759364002662 motif 3; other site 759364002663 Predicted permeases [General function prediction only]; Region: COG0795 759364002664 Predicted permeases [General function prediction only]; Region: COG0795 759364002665 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 759364002666 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 759364002667 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 759364002668 Ligand Binding Site [chemical binding]; other site 759364002669 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 759364002670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759364002671 Walker A motif; other site 759364002672 ATP binding site [chemical binding]; other site 759364002673 Walker B motif; other site 759364002674 arginine finger; other site 759364002675 Peptidase family M41; Region: Peptidase_M41; pfam01434 759364002676 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 759364002677 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 759364002678 RNase E interface [polypeptide binding]; other site 759364002679 trimer interface [polypeptide binding]; other site 759364002680 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 759364002681 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 759364002682 RNase E interface [polypeptide binding]; other site 759364002683 trimer interface [polypeptide binding]; other site 759364002684 active site 759364002685 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 759364002686 putative nucleic acid binding region [nucleotide binding]; other site 759364002687 G-X-X-G motif; other site 759364002688 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 759364002689 RNA binding site [nucleotide binding]; other site 759364002690 domain interface; other site 759364002691 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 759364002692 16S/18S rRNA binding site [nucleotide binding]; other site 759364002693 S13e-L30e interaction site [polypeptide binding]; other site 759364002694 25S rRNA binding site [nucleotide binding]; other site 759364002695 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 759364002696 nucleoside/Zn binding site; other site 759364002697 dimer interface [polypeptide binding]; other site 759364002698 catalytic motif [active] 759364002699 Protein of unknown function (DUF720); Region: DUF720; pfam05302 759364002700 Protein of unknown function (DUF720); Region: DUF720; pfam05302 759364002701 Protein of unknown function (DUF720); Region: DUF720; pfam05302 759364002702 methionine aminopeptidase; Provisional; Region: PRK12318 759364002703 SEC-C motif; Region: SEC-C; pfam02810 759364002704 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 759364002705 active site 759364002706 MarC family integral membrane protein; Region: MarC; pfam01914 759364002707 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 759364002708 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 759364002709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759364002710 dimer interface [polypeptide binding]; other site 759364002711 conserved gate region; other site 759364002712 putative PBP binding loops; other site 759364002713 ABC-ATPase subunit interface; other site 759364002714 NMT1/THI5 like; Region: NMT1; pfam09084 759364002715 fumarate hydratase, class II; Region: fumC_II; TIGR00979 759364002716 Class II fumarases; Region: Fumarase_classII; cd01362 759364002717 active site 759364002718 tetramer interface [polypeptide binding]; other site 759364002719 high affinity sulphate transporter 1; Region: sulP; TIGR00815 759364002720 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 759364002721 Sulfate transporter family; Region: Sulfate_transp; pfam00916 759364002722 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 759364002723 Na+/H+ antiporter, NhaD family; Region: NhaD; TIGR00775 759364002724 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 759364002725 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 759364002726 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 759364002727 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 759364002728 active site triad [active] 759364002729 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 759364002730 LytB protein; Region: LYTB; pfam02401 759364002731 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 759364002732 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 759364002733 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759364002734 binding surface 759364002735 TPR motif; other site 759364002736 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 759364002737 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 759364002738 active site 759364002739 DNA binding site [nucleotide binding] 759364002740 Int/Topo IB signature motif; other site 759364002741 glycogen branching enzyme; Provisional; Region: PRK05402 759364002742 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 759364002743 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 759364002744 active site 759364002745 catalytic site [active] 759364002746 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 759364002747 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 759364002748 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 759364002749 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 759364002750 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 759364002751 Autotransporter beta-domain; Region: Autotransporter; pfam03797 759364002752 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 759364002753 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 759364002754 Autotransporter beta-domain; Region: Autotransporter; pfam03797 759364002755 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 759364002756 Autotransporter beta-domain; Region: Autotransporter; pfam03797 759364002757 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 759364002758 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 759364002759 Autotransporter beta-domain; Region: Autotransporter; pfam03797 759364002760 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 759364002761 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 759364002762 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 759364002763 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 759364002764 Autotransporter beta-domain; Region: Autotransporter; pfam03797